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4. Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders – An individual patient data meta-analysis

Author

Campana, Mattia, Yakimov, Vladislav, Moussiopoulou, Joanna, Maurus, Isabel, Löhrs, Lisa, Raabe, Florian, Jäger, Iris, Mortazavi, Matin, Benros, Michael E., Jeppesen, Rose, Meyer zu Hörste, Gerd, Heming, Michael, Giné-Servén, Eloi, Labad, Javier, Boix, Ester, Lennox, Belinda, Yeeles, Ksenija, Steiner, Johann, Meyer-Lotz, Gabriela, Dobrowolny, Henrik, Malchow, Berend, Hansen, Niels, Falkai, Peter, Siafis, Spyridon, Leucht, Stefan, Halstead, Sean, Warren, Nicola, Siskind, Dan, Strube, Wolfgang, Hasan, Alkomiet, and Wagner, Elias

Published
2024
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16. Corrigendum: Psychosocial stress moderates the relationship between cerebrospinal fluid lactate dehydrogenase and the duration of untreated psychosis in first-episode psychosis

Author

Giné-Servén, Eloi, primary, Boix-Quintana, Ester, additional, Daví-Loscos, Eva, additional, Cepedello, Sandra, additional, Moreno-Sancho, Lara, additional, Niubó, Marta, additional, Hernández-Antón, Rebeca, additional, Cuesta, Manuel J., additional, and Labad, Javier, additional

Published
2024
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20. Cognitive biases are associated with clinical and functional variables in psychosis: A comparison across schizophrenia, early psychosis and healthy individuals

Author

Ahuir, Maribel, Crosas, Josep Maria, Estrada, Francesc, Zabala, Wanda, Pérez-Muñoz, Sara, González-Fernández, Alba, Tost, Meritxell, Aguayo, Raquel, Montalvo, Itziar, Miñano, Maria José, Gago, Estefania, Pàmias, Montserrat, Monreal, José Antonio, Palao, Diego, and Labad, Javier

Published
2021
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22. Psychosocial stress moderates the relationship between cerebrospinal fluid lactate dehydrogenase and the duration of untreated psychosis in first-episode psychosis.

Author

Giné-Servén, Eloi, Boix-Quintana, Ester, Daví-Loscos, Eva, Cepedello, Sandra, Moreno-Sancho, Lara, Niubó, Marta, Hernández-Antón, Rebeca, Cuesta, Manuel J., and Labad, Javier

Subjects
LACTATE dehydrogenase, CEREBROSPINAL fluid, LIFE change events, PSYCHOSES, MULTIPLE regression analysis, TUBERCULOUS meningitis
Abstract

Introduction: Previous research has shown that lower lactate dehydrogenase (LDH) concentrations in cerebrospinal fluid (CSF) are associated with longer prodromal symptoms in first-episode psychosis (FEP). We aimed to study whether there is a relationship between the duration of untreated psychosis (DUP) and LDH and other CSF biomarkers in FEP and whether stressful life events moderate this association. Methods: Ninety-five inpatients with FEP and with less than 6 weeks of antipsychotic treatment were included in the study. All participants were informed about the nature of the study, which was approved by the local ethics committee, and signed an informed consent form. A lumbar puncture was performed at index admission (baseline) to measure CSF parameters (glucose, total protein, LDH). The DUP was assessed with the Quick Psychosis Onset and Prodromal Symptoms Inventory (Q-POPSI). Stressful life events (SLEs) in the previous 6 months were assessed with the List of Threatening Experiences. We dichotomized the SLE variable into having experienced at least one SLE or no experience of SLEs. Statistical analyses were performed with SPSS v. 25.0. Total protein and LDH concentrations were natural log transformed (ln) to reduce skewness. Multiple linear regression analyses were conducted to explore the association between the DUP and CSF parameters (considered the dependent variable). Age, sex, DUP and SLEs were considered independent variables. We tested the DUP by SLE interaction. Significant interactions were included in the final model. The threshold for significance was set at p<0.05. Results: Fifty-four FEP patients (56.8%) reported an SLE in the previous 6 months. There were no significant differences in the DUP between patients with or without SLEs. There were no significant differences in CSF biomarkers between the SLE groups. In the multiple linear regression analyses, we found a significant DUP by SLE interaction effect on CSF LDH concentrations (standardized beta= -0.320, t= -2.084, p= 0.040). In patients with SLEs, a shorter DUP was associated with higher CSF LDH concentrations and vice versa. No significant associations were found between the DUP or SLEs and other CSF biomarkers (glucose, total proteins). Conclusions: Our study suggests that psychosocial stress moderates the relationship between the onset of psychosis and CSF biomarkers related to bioenergetic systems. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Corrigendum to “Prolactin and morning cortisol concentrations in antipsychotic naïve first episode psychosis: A systematic review and meta-analysis” [Psychoneuroendocrinology 150 (2023) 106049]

Author

Aymerich, Claudia, Pedruzo, Borja, Pacho, Malein, Laborda, María, Herrero, Jon, Pillinger, Toby, McCutcheon, Robert A., Alonso-Alconada, Daniel, Bordenave, Marta, Martínez-Querol, Maria, Arnaiz, Ainara, Labad, Javier, Fusar-Poli, Paolo, González-Torres, Miguel Ángel, and Catalan, Ana

Published
2024
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35. Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD

Author

Llorens, Marta, primary, Barba, Maria, additional, Torralbas-Ortega, Jordi, additional, Nadal, Roser, additional, Armario, Antonio, additional, Gagliano, Humberto, additional, Urraca, Lara, additional, Pujol, Susana, additional, Montalvo, Itziar, additional, Gracia, Rebeca, additional, Polo, Diana, additional, González-Riesco, Laura, additional, Matalí, Josep Lluís, additional, Palao, Diego, additional, Pàmias, Montserrat, additional, and Labad, Javier, additional

Published
2023
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47. Psychosocial stress moderates the relationship between cerebrospinal fluid lactate dehydrogenase and the duration of untreated psychosis in firstepisode psychosis.

Author

Giné-Servén, Eloi, Boix-Quintana, Ester, Daví-Loscos, Eva, Cepedello, Sandra, Moreno-Sancho, Lara, Niubó, Marta, Hernández-Antón, Rebeca, Cuesta, Manuel J., and Labad, Javier

Subjects
LACTATE dehydrogenase, CEREBROSPINAL fluid, LIFE change events, PSYCHOSES, MULTIPLE regression analysis, TUBERCULOUS meningitis
Abstract

Introduction: Previous research has shown that lower lactate dehydrogenase (LDH) concentrations in cerebrospinal fluid (CSF) are associated with longer prodromal symptoms in first-episode psychosis (FEP). We aimed to study whether there is a relationship between the duration of untreated psychosis (DUP) and LDH and other CSF biomarkers in FEP and whether stressful life events moderate this association. Methods: Ninety-five inpatients with FEP and with less than 6 weeks of antipsychotic treatment were included in the study. All participants were informed about the nature of the study, which was approved by the local ethics committee, and signed an informed consent form. A lumbar puncture was performed at index admission (baseline) to measure CSF parameters (glucose, total protein, LDH). The DUP was assessed with the Quick Psychosis Onset and Prodromal Symptoms Inventory (Q-POPSI). Stressful life events (SLEs) in the previous 6 months were assessed with the List of Threatening Experiences. We dichotomized the SLE variable into having experienced at least one SLE or no experience of SLEs. Statistical analyses were performed with SPSS v. 25.0. Total protein and LDH concentrations were natural log transformed (ln) to reduce skewness. Multiple linear regression analyses were conducted to explore the association between the DUP and CSF parameters (considered the dependent variable). Age, sex, DUP and SLEs were considered independent variables. We tested the DUP by SLE interaction. Significant interactions were included in the final model. The threshold for significance was set at p<0.05. Results: Fifty-four FEP patients (56.8%) reported an SLE in the previous 6 months. There were no significant differences in the DUP between patients with or without SLEs. There were no significant differences in CSF biomarkers between the SLE groups. In the multiple linear regression analyses, we found a significant DUP by SLE interaction effect on CSF LDH concentrations (standardized beta= -0.320, t= -2.084, p= 0.040). In patients with SLEs, a shorter DUP was associated with higher CSF LDH concentrations and vice versa. No significant associations were found between the DUP or SLEs and other CSF biomarkers (glucose, total proteins). Conclusions: Our study suggests that psychosocial stress moderates the relationship between the onset of psychosis and CSF biomarkers related to bioenergetic systems. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Gradual Increase in Inflammation-Linked Glycoproteins and a Proatherogenic Lipoprotein Profile in the Early Stages of Psychosis as Characterized by 1H NMR Blood Analysis

Author

Fundació La Marató de TV3, Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Muntané, Gerard [0000-0003-1541-8365], Gallart-Palau, Xavier, Muntané, Gerard, Martorell, Lourdes, Amigó, Núria, Correig, Xavier, Ribalta, Josep, Sánchez-Gistau, Vanessa, Labad, Javier, Vilella, Elisabet, Fundació La Marató de TV3, Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Muntané, Gerard [0000-0003-1541-8365], Gallart-Palau, Xavier, Muntané, Gerard, Martorell, Lourdes, Amigó, Núria, Correig, Xavier, Ribalta, Josep, Sánchez-Gistau, Vanessa, Labad, Javier, and Vilella, Elisabet

Abstract

Minimally invasive prognostic markers of inflammation and dyslipidemia in individuals with a risk of psychosis, also called “at-risk mental state” (ARMS), or in the first episode of psychosis (FEP) are of utmost clinical importance to prevent cardiovascular disorders. We analyzed the plasma concentration of inflammation-linked glycoproteins (Glycs) and lipoprotein subclasses by proton nuclear magnetic resonance (1H NMR) in a single acquisition. Study participants were healthy controls (HCs, N = 67) and patients with ARMS (N = 58), FEP (N = 110), or early psychosis diagnosis with ≥2 episodes (critical period (CP), N = 53). Clinical biomarkers such as high-sensitivity C-reactive protein, interleukin 6, fibrinogen, insulin, and lipoproteins were also measured. Although all participants had normal lipoprotein profiles and no inflammation according to conventional biomarkers, a gradual increase in the Glyc 1H NMR levels was observed from HCs to CP patients; this increase was statistically significant for GlycA (CP vs HC). In parallel, a progressive and significant proatherogenic 1H NMR lipoprotein profile was also identified across stages of psychosis (ARMS and CP vs HC). These findings highlight the potential of using 1H NMR Glyc and lipoprotein profiling to identify blood changes in individuals with ARMS or FEP and pave the way for applications using this technology to monitor metabolic and cardiovascular risks in clinical psychiatry.

Published
2023

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