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Your search keyword '"Laaper-Ertmann, M."' showing total 6 results
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6 results on '"Laaper-Ertmann, M."'

3. Purification and immunoglobulin E-binding properties of peanut allergen Ara h 6: Evidence for cross-reactivity with Ara h 2

Author

Koppelman, S.J., Jong, G.A.H.de, Laaper-Ertmann, M. de, Peeters, K.A.B.M., Knulst, A.C., Hefle, S.L., and Knol, E.F.

Subjects
Nutrition Safety, double blind procedure, Skin prick test, prick test, Ara h 2 allergen, Cross Reactions, antigen antibody reaction, immunoglobulin E, peanut agglutinin, Ara h 6 allergen, Antibody Specificity, Albumins, protein purification, Basophil, Hypersensitivity, Humans, controlled study, antigen binding, human, Amino Acid Sequence, cross reaction, Glycoproteins, Innovation Policy, Plant Proteins, carboxy terminal sequence, epitope, clinical article, controlled clinical trial, basophil degranulation, human cell, Allergen, adult, article, peanut allergy, molecular weight, clinical trial, sequence homology, Allergens, monomer, matrix assisted laser desorption ionization time of flight mass spectrometry, Recombinant Proteins, unclassified drug, Basophils, Peanut, priority journal, protein analysis, amino terminal sequence, IgE, immunoblotting
Abstract

Background: IgE-binding peanut proteins smaller than 15 kDa were previously identified as potential allergens in the majority of our peanut allergic population. Objective: To characterize the novel allergen in order to determine whether it was similar to one of the thus far identified recombinant peanut allergens (Ara h 1-7). Methods: An IgE-binding protein of

Published
2005

5. Modulation of lymphocyte function in vivo via inhibition of calcineurin or purine synthesis in patients with atopic dermatitis.

Author

Knol EF, Haeck IM, van Kraats AA, Laaper-Ertmann M, Giovannone B, Hijnen D, Nijhuis E, de Bruin-Weller MS, Knol MJ, and Bruijnzeel-Koomen CA

Subjects
B-Lymphocytes drug effects, Calcineurin metabolism, Cyclosporine pharmacology, Cyclosporine therapeutic use, DNA-Binding Proteins metabolism, Dermatitis, Atopic physiopathology, Forkhead Transcription Factors metabolism, Humans, Intracellular Signaling Peptides and Proteins metabolism, Mycophenolic Acid analogs & derivatives, Mycophenolic Acid pharmacology, Mycophenolic Acid therapeutic use, Nuclear Proteins metabolism, Purines metabolism, Severity of Illness Index, T-Lymphocytes drug effects, Treatment Outcome, Tumor Necrosis Factor alpha-Induced Protein 3, B-Lymphocytes physiology, Calcineurin Inhibitors, Dermatitis, Atopic metabolism, Dermatitis, Atopic pathology, Purines antagonists & inhibitors, T-Lymphocytes physiology
Published
2012
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6. Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis.

Author

Majoie IM, Oldhoff JM, van Weelden H, Laaper-Ertmann M, Bousema MT, Sigurdsson V, Knol EF, Bruijnzeel-Koomen CA, and de Bruin-Weller MS

Subjects
Adult, Dermatitis, Atopic pathology, Female, Humans, Immunohistochemistry, Male, Middle Aged, Severity of Illness Index, Single-Blind Method, Young Adult, Dermatitis, Atopic radiotherapy, Ultraviolet Therapy
Abstract

Background: Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD., Objectives: We sought to compare the clinical and immunohistochemical effects of narrowband (NB) UVB and MD UVA1 treatment in patients with AD., Methods: Thirteen adult patients with AD were included in this randomized investigator-blinded half-sided comparison study between NB UVB and MD UVA1. Disease activity was measured using the Leicester sign score. Skin biopsy specimens were taken before and after phototherapy. Regulatory T cells were stained with the forkhead box protein P3 (FoxP3)., Results: NB UVB and MD UVA1 both significantly decreased AD severity (P < .01) and the dermal cellular infiltrate. The percentage of FoxP3(+)CD3(+) T cells did not change after NB UVB or MD UVA1 treatment., Limitation: MD UVA1 therapy was given 3 times per week instead of the preferred regimen of 5 times per week. This was necessary to achieve good blinding of the study., Conclusions: NB UVB and MD UVA1 seem equally effective in the treatment of patients with moderate to severe AD. Neither MD UVA1 nor NB UVB had an effect on the percentage of FoxP3(+)CD3(+) T cells.

Published
2009
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