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2. Limited Relationship Between Echocardiographic Measures and Electrocardiographic Markers of Left Ventricular Size in Healthy Children

Author

Alexander, Mark E., Gongwer, Russell, Trachtenberg, Felicia L., Minich, L. LuAnn, Triedman, John K., Kaltman, Jonathan R., Czosek, Richard J., Tristani-Firouzi, Martin, LaPage, Martin J., Tsao, Sabrina S., Radbill, Andrew E., DiLorenzo, Michael P., Kovach, Joshua R., Stephenson, Elizabeth A., Janson, Christopher, Mao, Chad, Salerno, Jack C., Clark, Bradley C., Mahgerefteh, Joseph, Pilcher, Thomas, Johnson, Tiffanie R., Kim, Jeff J., Valdes, Santiago O., Cain, Nicole, Jackson, Lanier, and Saarel, Elizabeth V.

Published
2024
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4. An international multicenter cohort study on implantable cardioverter-defibrillators for the treatment of symptomatic children with catecholaminergic polymorphic ventricular tachycardia

Author

Lamba, Avani, Roston, Thomas M., Peltenburg, Puck J., Kallas, Dania, Franciosi, Sonia, Lieve, Krystien V.V., Kannankeril, Prince J., Horie, Minoru, Ohno, Seiko, Brugada, Ramon, Aiba, Takeshi, Fischbach, Peter, Knight, Linda, Till, Jan, Kwok, Sit-Yee, Probst, Vincent, Backhoff, David, LaPage, Martin J., Batra, Anjan S., Drago, Fabrizio, Haugaa, Kristina, Krahn, Andrew D., Robyns, Tomas, Swan, Heikki, Tavacova, Terezia, van der Werf, Christian, Atallah, Joseph, Borggrefe, Martin, Rudic, Boris, Sarquella-Brugada, Georgia, Chorin, Ehud, Hill, Allison, Kammeraad, Janneke, Kamp, Anna, Law, Ian, Perry, James, Roberts, Jason D., Tisma-Dupanovic, Svjetlana, Semsarian, Christopher, Skinner, Jonathan R., Tfelt-Hansen, Jacob, Denjoy, Isabelle, Leenhardt, Antoine, Schwartz, Peter J., Ackerman, Michael J., Blom, Nico A., Wilde, Arthur A.M., and Sanatani, Shubhayan

Published
2024
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6. Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Bergeman, Auke T., Lieve, Krystien V.V., Kallas, Dania, Bos, J. Martijn, Rosés i Noguer, Ferran, Denjoy, Isabelle, Zorio, Esther, Kammeraad, Janneke A.E., Peltenburg, Puck J., Tobert, Katie, Aiba, Takeshi, Atallah, Joseph, Drago, Fabrizio, Batra, Anjan S., Brugada, Ramon, Borggrefe, Martin, Clur, Sally-Ann B., Cox, Moniek G.P.J., Davis, Andrew, Dhillon, Santokh, Etheridge, Susan P., Fischbach, Peter, Franciosi, Sonia, Haugaa, Kristina, Horie, Minoru, Johnsrude, Christopher, Kane, Austin M., Krause, Ulrich, Kwok, Sit-Yee, LaPage, Martin J., Ohno, Seiko, Probst, Vincent, Roberts, Jason D., Robyns, Tomas, Sacher, Frederic, Semsarian, Christopher, Skinner, Jonathan R., Swan, Heikki, Tavacova, Terezia, Tisma-Dupanovic, Svjetlana, Tfelt-Hansen, Jacob, Yap, Sing-Chien, Kannankeril, Prince J., Leenhardt, Antoine, Till, Janice, Sanatani, Shubhayan, Tanck, Michael W.T., Ackerman, Michael J., Wilde, Arthur A.M., and van der Werf, Christian

Published
2023
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8. The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry.

Author

Roston, Thomas M, Yuchi, Zhiguang, Kannankeril, Prince J, Hathaway, Julie, Vinocur, Jeffrey M, Etheridge, Susan P, Potts, James E, Maginot, Kathleen R, Salerno, Jack C, Cohen, Mitchell I, Hamilton, Robert M, Pflaumer, Andreas, Mohammed, Saira, Kimlicka, Lynn, Kanter, Ronald J, LaPage, Martin J, Collins, Kathryn K, Gebauer, Roman A, Temple, Joel D, Batra, Anjan S, Erickson, Christopher, Miszczak-Knecht, Maria, Kubuš, Peter, Bar-Cohen, Yaniv, Kantoch, Michal, Thomas, Vincent C, Hessling, Gabriele, Anderson, Chris, Young, Ming-Lon, Choi, Sally HJ, Cabrera Ortega, Michel, Lau, Yung R, Johnsrude, Christopher L, Fournier, Anne, Van Petegem, Filip, and Sanatani, Shubhayan

Subjects
Cardiovascular, Heart Disease, Pediatric, Clinical Research, Genetics, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Calsequestrin, Child, DNA Mutational Analysis, Death, Sudden, Cardiac, Female, Genetic Markers, Genetic Predisposition to Disease, Heredity, Humans, Male, Models, Molecular, Mutation, Pedigree, Phenotype, Prognosis, Protein Conformation, Registries, Retrospective Studies, Risk Factors, Ryanodine Receptor Calcium Release Channel, Structure-Activity Relationship, Tachycardia, Ventricular, Catecholaminergic polymorphic, Ventricular tachycardia, RyR2, Arrhythmia, Sudden unexpected death, Clinical Sciences, Cardiovascular System & Hematology
Abstract

AimsCatecholaminergic polymorphic ventricular tachycardia (CPVT) is an ion channelopathy characterized by ventricular arrhythmia during exertion or stress. Mutations in RYR2-coded Ryanodine Receptor-2 (RyR2) and CASQ2-coded Calsequestrin-2 (CASQ2) genes underlie CPVT1 and CPVT2, respectively. However, prognostic markers are scarce. We sought to better characterize the phenotypic and genotypic spectrum of CPVT, and utilize molecular modelling to help account for clinical phenotypes.Methods and resultsThis is a Pediatric and Congenital Electrophysiology Society multicentre, retrospective cohort study of CPVT patients diagnosed at

Published
2018

9. Catecholaminergic polymorphic ventricular tachycardia patients with multiple genetic variants in the PACES CPVT Registry

Author

Roston, Thomas M, Haji-Ghassemi, Omid, LaPage, Martin J, Batra, Anjan S, Bar-Cohen, Yaniv, Anderson, Chris, Lau, Yung R, Maginot, Kathleen, Gebauer, Roman A, Etheridge, Susan P, Potts, James E, Van Petegem, Filip, and Sanatani, Shubhayan

Subjects
Pediatric, Rare Diseases, Cardiovascular, Heart Disease, Human Genome, Genetics, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Adolescent, Child, Child, Preschool, Female, Genetic Predisposition to Disease, Humans, Infant, Newborn, Male, Myocardium, Protein Domains, Registries, Ryanodine Receptor Calcium Release Channel, Tachycardia, Ventricular, Treatment Outcome, General Science & Technology
Abstract

BackgroundCatecholaminergic polymorphic ventricular tachycardia (CPVT) is often a life-threatening arrhythmia disorder with variable penetrance and expressivity. Little is known about the incidence or outcomes of CPVT patients with ≥2 variants.MethodsThe phenotypes, genotypes and outcomes of patients in the Pediatric and Congenital Electrophysiology Society CPVT Registry with ≥2 variants in genes linked to CPVT were ascertained. The American College of Medical Genetics & Genomics (ACMG) criteria and structural mapping were used to predict the pathogenicity of variants (3D model of pig RyR2 in open-state).ResultsAmong 237 CPVT subjects, 193 (81%) had genetic testing. Fifteen patients (8%) with a median age of 9 years (IQR 5-12) had ≥2 variants. Sudden cardiac arrest occurred in 11 children (73%), although none died during a median follow-up of 4.3 years (IQR 2.5-6.1). Thirteen patients (80%) had at least two RYR2 variants, while the remaining two patients had RYR2 variants plus variants in other CPVT-linked genes. Among all variants identified, re-classification of the commercial laboratory interpretation using ACMG criteria led to the upgrade from variant of unknown significance (VUS) to pathogenic/likely pathogenic (P/LP) for 5 variants, and downgrade from P/LP to VUS for 6 variants. For RYR2 variants, 3D mapping using the RyR2 model suggested that 2 VUS by ACMG criteria were P/LP, while 2 variants were downgraded to likely benign.ConclusionsThis severely affected cohort demonstrates that a minority of CPVT cases are related to ≥2 variants, which may have implications on family-based genetic counselling. While multi-variant CPVT patients were at high-risk for sudden cardiac arrest, there are insufficient data to conclude that this genetic phenomenon has prognostic implications at present. Further research is needed to determine the significance and generalizability of this observation. This study also shows that a rigorous approach to variant re-classification using the ACMG criteria and 3D mapping is important in reaching an accurate diagnosis, especially in the multi-variant population.

Published
2018

10. 2021 PACES expert consensus statement on the indications and management of cardiovascular implantable electronic devices in pediatric patients

Author

Chang, Philip M., Drago, Fabrizio, Dubin, Anne M., Etheridge, Susan P., Kongpatanayothin, Apichai, Moltedo, Jose Manuel, Nabar, Ashish A., Van Hare, George F., Shah, Maully J., Silka, Michael J., Avari Silva, Jennifer N., Balaji, Seshadri, Beach, Cheyenne M., Benjamin, Monica N., Berul, Charles I., Cannon, Bryan, Cecchin, Frank, Cohen, Mitchell I., Dalal, Aarti S., Dechert, Brynn E., Foster, Anne, Gebauer, Roman, Gonzalez Corcia, M. Cecilia, Kannankeril, Prince J., Karpawich, Peter P., Kim, Jeffery J., Krishna, Mani Ram, Kubuš, Peter, LaPage, Martin J., Mah, Douglas Y., Malloy-Walton, Lindsey, Miyazaki, Aya, Motonaga, Kara S., Niu, Mary C., Olen, Melissa, Paul, Thomas, Rosenthal, Eric, Saarel, Elizabeth V., Silvetti, Massimo Stefano, Stephenson, Elizabeth A., Tan, Reina B., Triedman, John, Von Bergen, Nicholas H., and Wackel, Philip L.

Published
2021
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11. 2021 PACES Expert Consensus Statement on the Indications and Management of Cardiovascular Implantable Electronic Devices in Pediatric Patients: Developed in Collaboration With and Endorsed by the Heart Rhythm Society (HRS), the American College of Cardiology (ACC), the American Heart Association (AHA), and the Association for European Paediatric and Congenital Cardiology (AEPC) Endorsed by the Asia Pacific Heart Rhythm Society (APHRS), the Indian Heart Rhythm Society (IHRS), and the Latin American Heart Rhythm Society (LAHRS)

Author

Shah, Maully J., Silka, Michael J., Silva, Jennifer N. Avari, Balaji, Seshadri, Beach, Cheyenne M., Benjamin, Monica N., Berul, Charles I., Cannon, Bryan, Cecchin, Frank, Cohen, Mitchell I., Dalal, Aarti S., Dechert, Brynn E., Foster, Anne, Gebauer, Roman, Gonzalez Corcia, M. Cecilia, Kannankeril, Prince J., Karpawich, Peter P., Kim, Jeffery J., Krishna, Mani Ram, Kubuš, Peter, LaPage, Martin J., Mah, Douglas Y., Malloy-Walton, Lindsey, Miyazaki, Aya, Motonaga, Kara S., Niu, Mary C., Olen, Melissa, Paul, Thomas, Rosenthal, Eric, Saarel, Elizabeth V., Silvetti, Massimo Stefano, Stephenson, Elizabeth A., Tan, Reina B., Triedman, John, Bergen, Nicholas H. Von, and Wackel, Philip L.

Published
2021
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12. 2021 PACES Expert Consensus Statement on the Indications and Management of Cardiovascular Implantable Electronic Devices in Pediatric Patients

Author

Shah, Maully J., Silka, Michael J., Silva, Jennifer N. Avari, Balaji, Seshadri, Beach, Cheyenne M., Benjamin, Monica N., Berul, Charles I., Cannon, Bryan, Cecchin, Frank, Cohen, Mitchell I., Dalal, Aarti S., Dechert, Brynn E., Foster, Anne, Gebauer, Roman, Gonzalez Corcia, M. Cecilia, Kannankeril, Prince J., Karpawich, Peter P., Kim, Jeffery J., Krishna, Mani Ram, Kubuš, Peter, LaPage, Martin J., Mah, Douglas Y., Malloy-Walton, Lindsey, Miyazaki, Aya, Motonaga, Kara S., Niu, Mary C., Olen, Melissa, Paul, Thomas, Rosenthal, Eric, Saarel, Elizabeth V., Silvetti, Massimo Stefano, Stephenson, Elizabeth A., Tan, Reina B., Triedman, John, Bergen, Nicholas H. Von, and Wackel, Philip L.

Published
2021
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13. 2021 PACES Expert Consensus Statement on the Indications and Management of Cardiovascular Implantable Electronic Devices in Pediatric Patients: Executive Summary

Author

Silka, Michael J., Shah, Maully J., Silva, Jennifer N. Avari, Balaji, Seshadri, Beach, Cheyenne M., Benjamin, Monica N., Berul, Charles I., Cannon, Bryan, Cecchin, Frank, Cohen, Mitchell I., Dalal, Aarti S., Dechert, Brynn E., Foster, Anne, Gebauer, Roman, Gonzalez Corcia, M. Cecilia, Kannankeril, Prince J., Karpawich, Peter P., Kim, Jeffery J., Krishna, Mani Ram, Kubuš, Peter, LaPage, Martin J., Mah, Douglas Y., Malloy-Walton, Lindsey, Miyazaki, Aya, Motonaga, Kara S., Niu, Mary C., Olen, Melissa, Paul, Thomas, Rosenthal, Eric, Saarel, Elizabeth V., Silvetti, Massimo Stefano, Stephenson, Elizabeth A., Tan, Reina B., Triedman, John, Von Bergen, Nicholas H., and Wackel, Philip L.

Published
2021
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14. Evaluation of age at symptom onset, proband status, and sex as predictors of disease severity in pediatric catecholaminergic polymorphic ventricular tachycardia

Author

Kallas, Dania, Roston, Thomas M., Franciosi, Sonia, Brett, Laura, Lieve, Krystien V.V., Kwok, Sit-Yee, Kannankeril, Prince J., Krahn, Andrew D., LaPage, Martin J., Etheridge, Susan, Hill, Allison, Johnsrude, Christopher, Perry, James, Knight, Linda, Fischbach, Peter, Balaji, Seshadri, Tisma-Dupanovic, Svjetlana, Law, Ian, Atallah, Joseph, Backhoff, David, Kamp, Anna, Kubus, Peter, Kean, Adam, Aziz, Peter F., Kovach, Joshua, Lau, Yung, Kron, Jordana, Clur, Sally-Ann, Sarquella-Brugada, Georgia, Wilde, Arthur A.M., and Sanatani, Shubhayan

Published
2021
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16. Catecholaminergic Polymorphic Ventricular Tachycardia in Children

Author

Roston, Thomas M, Vinocur, Jeffrey M, Maginot, Kathleen R, Mohammed, Saira, Salerno, Jack C, Etheridge, Susan P, Cohen, Mitchell, Hamilton, Robert M, Pflaumer, Andreas, Kanter, Ronald J, Potts, James E, LaPage, Martin J, Collins, Kathryn K, Gebauer, Roman A, Temple, Joel D, Batra, Anjan S, Erickson, Christopher, Miszczak-Knecht, Maria, Kubuš, Peter, Bar-Cohen, Yaniv, Kantoch, Michal, Thomas, Vincent C, Hessling, Gabriele, Anderson, Chris, Young, Ming-Lon, Cabrera Ortega, Michel, Lau, Yung R, Johnsrude, Christopher L, Fournier, Anne, Kannankeril, Prince J, and Sanatani, Shubhayan

Subjects
Heart Disease, Cardiovascular, Clinical Research, Neurosciences, Pediatric, Adolescent, Age Factors, Anti-Arrhythmia Agents, Child, Death, Sudden, Cardiac, Defibrillators, Implantable, Electric Countershock, Female, Humans, Male, Patient Selection, Phenotype, Registries, Retrospective Studies, Risk Factors, Severity of Illness Index, Sympathectomy, Tachycardia, Ventricular, Time Factors, Treatment Outcome, polymorphic catecholaminergic ventricular tachycardia, implanted cardioverter defibrillator, flecainide, sudden unexpected death, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Medical Physiology, Cardiovascular System & Hematology
Abstract

BackgroundCatecholaminergic polymorphic ventricular tachycardia is an uncommon, potentially lethal, ion channelopathy. Standard therapies have high failure rates and little is known about treatment in children. Newer options such as flecainide and left cardiac sympathetic denervation are not well validated. We sought to define treatment outcomes in children with catecholaminergic polymorphic ventricular tachycardia.Methods and resultsThis is a Pediatric and Congenital Electrophysiology Society multicenter, retrospective cohort study of catecholaminergic polymorphic ventricular tachycardia patients diagnosed before 19 years of age. The cohort included 226 patients, including 170 probands and 56 relatives. Symptomatic presentation was reported in 176 (78%). Symptom onset occurred at 10.8 (interquartile range, 6.8-13.2) years with a delay to diagnosis of 0.5 (0-2.6) years. Syncope (P

Published
2015

19. Development and impact of arrhythmias after the Norwood procedure: A report from the Pediatric Heart Network

Author

Oster, Matthew E., Chen, Shan, Dagincourt, Nicholas, Bar-Cohen, Yaniv, Brothers, Matthew, Cain, Nicole, Colan, Steven D., Czosek, Richard J., Decker, Jamie A., Gamboa, David G., Idriss, Salim F., Kirsh, Joel A., LaPage, Martin J., Ohye, Richard G., Radojewski, Elizabeth, Shah, Maully, Silver, Eric S., Singh, Anoop K., Temple, Joel D., Triedman, John, and Kaltman, Jonathan R.

Published
2017
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20. Abstract 15531: Limited Relationship Between Echocardiographic Measures and Electrocardiographic Markers of Left Ventricular Dimensions in Healthy Children

Author

Alexander, Mark E, Gongwer, Russell, Trachtenberg, Felicia, Minich, Luann, Triedman, John K, Kaltman, Jonathan, Czosek, Richard J, Tristani, Martin, LaPage, Martin J, Tsao, Sabrina, Radbill, Andrew E, Dilorenzo, Michael, Kovach, Joshua R, Stephenson, Elizabeth A, Janson, Christopher, Mao, Chad Y, Salerno, Jack C, Mahgerefteh, Joseph, Pilcher, Thomas A, Johnson, Tiffanie R, Valdes, Santiago O, Jackson, Lanier, and Saarel, Elizabeth V

Published
2020
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28. PO-03-149 CURRENT STATE OF CARDIAC IMPLANTABLE ELECTRONIC DEVICE REMOTE MONITORING IN PEDIATRICS AND CONGENITAL HEART DISEASE: A PACES-SPONSORED QUALITY IMPROVEMENT INITIATIVE

Author

Clark, Bradley C., primary, Mah, Douglas Y., additional, Tanel, Ronn E., additional, Brateng, Caitlin, additional, Connell, Patrick S., additional, Dechert-Crooks, Brynn E., additional, Tisma-Dupanovic, Svjetlana, additional, Fenrich, Arnold L., additional, Hill, Allison C., additional, Jarosz, Elizabeth E., additional, LaPage, Martin J., additional, McCanta, Anthony C., additional, Malloy-Walton, Lindsey E., additional, Olen, Melissa, additional, Pflaumer, Andreas, additional, Radbill, Andrew E., additional, Smoots, Karen A., additional, Whitehill, Robert D., additional, and Dalal, Aarti, additional

Published
2023
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29. Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Bergeman, Auke T, Lieve, Krystien V V, Kallas, Dania, Bos, J Martijn, Rosés I Noguer, Ferran, Denjoy, Isabelle, Zorio, Esther, Kammeraad, Janneke A E, Peltenburg, Puck J, Tobert, Katie, Aiba, Takeshi, Atallah, Joseph, Drago, Fabrizio, Batra, Anjan S, Brugada, Ramon, Borggrefe, Martin, Clur, Sally-Ann B, Cox, Moniek G P J, Davis, Andrew, Dhillon, Santokh, Etheridge, Susan P, Fischbach, Peter, Franciosi, Sonia, Haugaa, Kristina, Horie, Minoru, Johnsrude, Christopher, Kane, Austin M, Krause, Ulrich, Kwok, Sit-Yee, LaPage, Martin J, Ohno, Seiko, Probst, Vincent, Roberts, Jason D, Robyns, Tomas, Sacher, Frederic, Semsarian, Christopher, Skinner, Jonathan R, Swan, Heikki, Tavacova, Terezia, Tisma-Dupanovic, Svjetlana, Tfelt-Hansen, Jacob, Yap, Sing-Chien, Kannankeril, Prince J, Leenhardt, Antoine, Till, Janice, Sanatani, Shubhayan, Tanck, Michael W T, Ackerman, Michael J, Wilde, Arthur A M, van der Werf, Christian, Bergeman, Auke T, Lieve, Krystien V V, Kallas, Dania, Bos, J Martijn, Rosés I Noguer, Ferran, Denjoy, Isabelle, Zorio, Esther, Kammeraad, Janneke A E, Peltenburg, Puck J, Tobert, Katie, Aiba, Takeshi, Atallah, Joseph, Drago, Fabrizio, Batra, Anjan S, Brugada, Ramon, Borggrefe, Martin, Clur, Sally-Ann B, Cox, Moniek G P J, Davis, Andrew, Dhillon, Santokh, Etheridge, Susan P, Fischbach, Peter, Franciosi, Sonia, Haugaa, Kristina, Horie, Minoru, Johnsrude, Christopher, Kane, Austin M, Krause, Ulrich, Kwok, Sit-Yee, LaPage, Martin J, Ohno, Seiko, Probst, Vincent, Roberts, Jason D, Robyns, Tomas, Sacher, Frederic, Semsarian, Christopher, Skinner, Jonathan R, Swan, Heikki, Tavacova, Terezia, Tisma-Dupanovic, Svjetlana, Tfelt-Hansen, Jacob, Yap, Sing-Chien, Kannankeril, Prince J, Leenhardt, Antoine, Till, Janice, Sanatani, Shubhayan, Tanck, Michael W T, Ackerman, Michael J, Wilde, Arthur A M, and van der Werf, Christian

Abstract

BACKGROUND: In severely affected patients with catecholaminergic polymorphic ventricular tachycardia, beta-blockers are often insufficiently protective. The purpose of this study was to evaluate whether flecainide is associated with a lower incidence of arrhythmic events (AEs) when added to beta-blockers in a large cohort of patients with catecholaminergic polymorphic ventricular tachycardia.METHODS: From 2 international registries, this multicenter case cross-over study included patients with a clinical or genetic diagnosis of catecholaminergic polymorphic ventricular tachycardia in whom flecainide was added to beta-blocker therapy. The study period was defined as the period in which background therapy (ie, beta-blocker type [beta1-selective or nonselective]), left cardiac sympathetic denervation, and implantable cardioverter defibrillator treatment status, remained unchanged within individual patients and was divided into pre-flecainide and on-flecainide periods. The primary end point was AEs, defined as sudden cardiac death, sudden cardiac arrest, appropriate implantable cardioverter defibrillator shock, and arrhythmic syncope. The association of flecainide with AE rates was assessed using a generalized linear mixed model assuming negative binomial distribution and random effects for patients.RESULTS: A total of 247 patients (123 [50%] females; median age at start of flecainide, 18 years [interquartile range, 14-29]; median flecainide dose, 2.2 mg/kg per day [interquartile range, 1.7-3.1]) were included. At baseline, all patients used a beta-blocker, 70 (28%) had an implantable cardioverter defibrillator, and 21 (9%) had a left cardiac sympathetic denervation. During a median pre-flecainide follow-up of 2.1 years (interquartile range, 0.4-7.2), 41 patients (17%) experienced 58 AEs (annual event rate, 5.6%). During a median on-flecainide follow-up of 2.9 years (interquartile range, 1.0-6.0), 23 patients (9%) experienced 38 AEs (annual event rate

Published
2023

35. PE-568-04 A DISTINCT AND POTENTIALLY MORE SEVERE NEUROCARDIAC PHENOTYPE AMONG PEDIATRIC PATIENTS WITH CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA

Author

Miyake, Christina Y., primary, Kallas, Dania, additional, Fischbach, Peter S., additional, LaPage, Martin J., additional, Law, Ian H., additional, Hill, Allison C., additional, Kannankeril, Prince J., additional, Fish, Frank A., additional, Howard, Taylor S., additional, Valdes, Santiago O., additional, Pham, Tam Dan N., additional, Stephens, Sara, additional, Kim, Jeffrey J., additional, Dhillon, Santokh S., additional, Johnsrude, Christopher L., additional, Wilberg, Yannic, additional, Krause, Ulrich, additional, Sarquella-Brugada, Georgia, additional, and Sanatani, Shubhayan, additional

Published
2022
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37. Relation of Norwood Shunt Type and Frequency of Arrhythmias at 6 Years (from the Single Ventricle Reconstruction Trial)

Author

Cain, Nicole, primary, Saul, J. Philip, additional, Gongwer, Russell, additional, Trachtenberg, Felicia, additional, Czosek, Richard J., additional, Kim, Jeffrey J., additional, Kaltman, Jonathon R., additional, LaPage, Martin J., additional, Janson, Christopher M., additional, Singh, Anoop K., additional, Hill, Allison C., additional, Landstrom, Andrew P., additional, Thacker, Deepika, additional, Niu, Mary C., additional, DeWitt, Elizabeth S., additional, Bulic, Anica, additional, Silver, Eric S., additional, Whitehill, Robert D., additional, Decker, Jamie, additional, and Newburger, Jane W., additional

Published
2022
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40. An International Multi-Center Cohort Study on ß-blockers for the Treatment of Symptomatic Children with Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Peltenburg, Puck J., Kallas, Dania, Bos, Johan M., Lieve KVV, Franciosi, Sonia, Roston, Thomas M., Denjoy, Isabelle, Sorensen, Katrina B., Ohno, Seiko, Roses-Noguer, Ferran, Aiba, Takeshi, Maltret, Alice, LaPage, Martin J., Atallah, Joseph, Giudicessi, John R., Clur, Sally-Ann B., Blom, Nico A., Tanck, Michael, Extramiana, Fabrice, Kato, Koichi, Barc, Julien, Borggrefe, Martin, Behr, Elijah R., Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Zorio, Esther, Swan, Heikki, Kammeraad JAE, Krahn, Andrew D., Davis, Andrew, Sacher, Frederic, Schwartz, Peter J., Roberts, Jason D., Skinner, Jonathan R., van den Berg, Maarten P., Kannankeril, Prince J., Drago, Fabrizio, Robyns, Tomas, Haugaa, Kristina, Tavacova, Terezia, Semsarian, Christopher, Till, Jan, Probst, Vincent, Brugada, Ramon, Shimizu, Wataru, Horie, Minoru, Leenhardt, Antoine, Ackerman, Michael J., Sanatani, Shubhayan, van der Werf, Christian, and Wilde AAM

Subjects
nadolol, metoprolol, death, sudden, cardiac, atenolol, polymorphic catecholergic ventricular tachycardia, child, propranolol
Abstract

Background: Symptomatic children with catecholaminergic polymorphic ventricular tachycardia (CPVT) are at risk for recurrent arrhythmic events. Beta-blockers (BBs) decrease this risk, but studies comparing individual BBs in sizeable cohorts are lacking. We aimed to assess the association between risk for arrhythmic events and type of BB in a large cohort of symptomatic children with CPVT. Methods: From two international registries of patients with CPVT, RYR2 variant-carrying symptomatic children (defined as syncope or sudden cardiac arrest prior to BB initiation and age at start of BB therapy

Published
2022

41. PO-01-035 CATHETER ABLATION FOR ATRIAL TACHYARRHYTHMIAS IN ADULTS WITH FONTAN PALLIATION: A MULTICENTER STUDY FROM THE PEDIATRIC AND CONGENITAL ELECTROPHYSIOLOGY SOCIETY (PACES) AND INTERNATIONAL SOCIETY FOR ADULT CONGENITAL HEART DISEASE (ISACHD)

Author

Kamp, Anna N., Moore, Jeremy P., Shay, Victoria, Alvarado, Chance, Ceresnak, Scott R., BESSIERE, Francis, Hale, Benjamin, LaPage, Martin J., Chang, Philip M., Pilcher, Thomas A., Kilinc, Orhan U., Al-mousily, Mohammad, von Alvensleben, Johannes C., Dionne, Audrey, De Groot, Natasja M., Fish, Frank A., and Khairy, Paul

Published
2024
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43. PE-482887-002 TRANSBAFFLE AND TRANSCONDUIT ACCESS FOR CATHETER ABLATION OF ATRIAL TACHYARRHYTHMIA IN ADULTS WITH FONTAN PALLIATION: A PEDIATRIC AND ADULT CONGENITAL ELECTROPHYSIOLOGY SOCIETY AND INTERNATIONAL SOCIETY OF ADULT CONGENITAL HEART DISEASE MULTICENTER STUDY

Author

Kamp, Anna N., Khairy, Paul, Shay, Victoria, Alvarado, Chance, BESSIERE, Francis, Ceresnak, Scott R., Hale, Benjamin, LaPage, Martin J., Pilcher, Thomas A., Chang, Philip M., Kilinc, Orhan U., Al-mousily, Mohammad, von Alvensleben, Johannes C., Dionne, Audrey, De Groot, Natasja M., Fish, Frank A., and Moore, Jeremy P.

Published
2024
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45. Safety and Results of Cryoablation in Patients

Author

LaPage, Martin J., Reed, John H., Collins, Kathryn K., Law, Ian H., Pilcher, Thomas A., Tanel, Ronn E., Anderson, Charles C., Young, Ming-Lon, Emmel, Mathias, Paul, Thomas, Blaufox, Andrew D., Arora, Gaurav, and Saul, J. Philip

Published
2011
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46. An International Multicenter Cohort Study on β-Blockers for the Treatment of Symptomatic Children With Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Peltenburg, Puck J., primary, Kallas, Dania, additional, Bos, Johan M., additional, Lieve, Krystien V.V., additional, Franciosi, Sonia, additional, Roston, Thomas M., additional, Denjoy, Isabelle, additional, Sorensen, Katrina B., additional, Ohno, Seiko, additional, Roses-Noguer, Ferran, additional, Aiba, Takeshi, additional, Maltret, Alice, additional, LaPage, Martin J., additional, Atallah, Joseph, additional, Giudicessi, John R., additional, Clur, Sally-Ann B., additional, Blom, Nico A., additional, Tanck, Michael, additional, Extramiana, Fabrice, additional, Kato, Koichi, additional, Barc, Julien, additional, Borggrefe, Martin, additional, Behr, Elijah R., additional, Sarquella-Brugada, Georgia, additional, Tfelt-Hansen, Jacob, additional, Zorio, Esther, additional, Swan, Heikki, additional, Kammeraad, Janneke A.E., additional, Krahn, Andrew D., additional, Davis, Andrew, additional, Sacher, Frederic, additional, Schwartz, Peter J., additional, Roberts, Jason D., additional, Skinner, Jonathan R., additional, van den Berg, Maarten P., additional, Kannankeril, Prince J., additional, Drago, Fabrizio, additional, Robyns, Tomas, additional, Haugaa, Kristina, additional, Tavacova, Terezia, additional, Semsarian, Christopher, additional, Till, Jan, additional, Probst, Vincent, additional, Brugada, Ramon, additional, Shimizu, Wataru, additional, Horie, Minoru, additional, Leenhardt, Antoine, additional, Ackerman, Michael J., additional, Sanatani, Shubhayan, additional, van der Werf, Christian, additional, and Wilde, Arthur A.M., additional

Published
2022
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47. Clinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome

Author

Roston, Thomas M., primary, Wei, Jinhong, additional, Guo, Wenting, additional, Li, Yanhui, additional, Zhong, Xiaowei, additional, Wang, Ruiwu, additional, Estillore, John Paul, additional, Peltenburg, Puck J., additional, Noguer, Ferran Rosés I., additional, Till, Jan, additional, Eckhardt, Lee L., additional, Orland, Kate M., additional, Hamilton, Robert, additional, LaPage, Martin J., additional, Krahn, Andrew D., additional, Tadros, Rafik, additional, Vinocur, Jeffrey M., additional, Kallas, Dania, additional, Franciosi, Sonia, additional, Roberts, Jason D., additional, Wilde, Arthur A. M., additional, Jensen, Henrik K., additional, Sanatani, Shubhayan, additional, and Chen, S. R. Wayne, additional

Published
2022
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50. 2021 PACES expert consensus statement on the indications and management of cardiovascular implantable electronic devices in pediatric patients

Author

Shah, Maully J., primary, Silka, Michael J., additional, Avari Silva, Jennifer N., additional, Balaji, Seshadri, additional, Beach, Cheyenne M., additional, Benjamin, Monica N., additional, Berul, Charles I., additional, Cannon, Bryan, additional, Cecchin, Frank, additional, Cohen, Mitchell I., additional, Dalal, Aarti S., additional, Dechert, Brynn E., additional, Foster, Anne, additional, Gebauer, Roman, additional, Gonzalez Corcia, M. Cecilia, additional, Kannankeril, Prince J., additional, Karpawich, Peter P., additional, Kim, Jeffery J., additional, Krishna, Mani Ram, additional, Kubuš, Peter, additional, LaPage, Martin J., additional, Mah, Douglas Y., additional, Malloy-Walton, Lindsey, additional, Miyazaki, Aya, additional, Motonaga, Kara S., additional, Niu, Mary C., additional, Olen, Melissa, additional, Paul, Thomas, additional, Rosenthal, Eric, additional, Saarel, Elizabeth V., additional, Silvetti, Massimo Stefano, additional, Stephenson, Elizabeth A., additional, Tan, Reina B., additional, Triedman, John, additional, Von Bergen, Nicholas H., additional, Wackel, Philip L., additional, Chang, Philip M., additional, Drago, Fabrizio, additional, Dubin, Anne M., additional, Etheridge, Susan P., additional, Kongpatanayothin, Apichai, additional, Moltedo, Jose Manuel, additional, Nabar, Ashish A., additional, and Van Hare, George F., additional

Published
2021
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