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1. Multicenter Evaluation of the Xpert MRSA NxG Assay for Detection of Methicillin-Resistant Staphylococcus aureus in Nasal Swabs

Author

Yarbrough, Melanie L, Warren, David K, Allen, Karen, Burkholder, Dennis, Daum, Robert, Donskey, Curtis, Knaack, Dennis, LaMarca, Anthony, May, Larissa, Miller, Loren G, Parenti, David M, Peterson, Lance, Tan, Thean Yen, Widen, Raymond, Hernandez, Diana R, Wolk, Donna M, and Burnham, Carey-Ann D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Vaccine Related, Prevention, Emerging Infectious Diseases, Clinical Research, Antimicrobial Resistance, Infectious Diseases, Infection, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Bacteriological Techniques, Child, Child, Preschool, DNA, Bacterial, Female, Humans, Male, Methicillin-Resistant Staphylococcus aureus, Middle Aged, Nasal Cavity, Polymerase Chain Reaction, Reagent Kits, Diagnostic, Sensitivity and Specificity, Staphylococcal Infections, Young Adult, methicillin-resistant Staphylococcus aureus, bacterial colonization, nasal swab, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Microbiology, Clinical sciences, Medical microbiology
Abstract

Health care-associated methicillin-resistant Staphylococcus aureus (MRSA) infections are a burden on the health care system. Clinical laboratories play a key role in reducing this burden, as the timely identification of MRSA colonization or infection facilitates infection control practices that are effective at limiting invasive MRSA infections. The Xpert MRSA NxG assay recently received FDA clearance for the direct detection of MRSA from nasal swabs. This multicenter study evaluated the clinical performance characteristics of the Xpert MRSA NxG assay with prospectively collected rayon nasal swabs (n = 1,103) and flocked swab (ESwab) nasal specimens (n = 846). Culture-based identification methods and antimicrobial susceptibility testing were used as the reference standards for comparison. According to the reference method, the positivity rates for MRSA in the population evaluated were 11.1% (122/1,103) for rayon swabs and 11.6% (98/846) for flocked swabs. The overall sensitivity and specificity of the rayon swabs were 91.0% (95% confidence interval [CI], 84.6 to 94.9%) and 96.9% (95% CI, 95.7 to 97.8%), respectively, across eight testing sites. The flocked swab specimens were 92.9% sensitive (95% CI, 86.0 to 96.5%) and 97.6% specific (95% CI, 96.2 to 98.5%) for MRSA detection across six testing sites. The sensitivity and specificity of the combined flocked and rayon swab data were 91.8% (95% CI, 87.4 to 94.8%) and 97.2% (95% CI, 96.3 to 97.9%), respectively. The positive predictive value (PPV) for rayon swabs was 78.7%, versus 83.5% for ESwabs. The negative predictive values (NPVs) for rayon swabs and ESwab specimens were 98.9% and 99.1%, respectively. In conclusion, the Xpert MRSA NxG assay is a sensitive and specific assay for the direct detection of MRSA from nasal swab specimens.

Published
2018

2. Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Antinori, Andrea, Apea, Vanessa, Asmuth, David, Avery, Ann, Benson, Paul, Bergin, Colm, Berhe, Mezgebe, Brar, Indira, Brinson, Cynthia, Brunetta, Jason, Burack, Jeffrey, Campbell, Thomas, Cespedes, Michelle, Clarke, Amanda, Coleman, Megan, Coll, Josep, Crespo Casal, Manuel, Creticos, Catherine, Crofoot, Gordon, Cruickshank, Frederick, Cua, Eric, Daar, Eric, de Wet, Joseph, DeJesus, Edwin, Del Romero Guerrero, Jorge, Dinges, William, Doblecki-Lewis, Susanne, Donovan, Taylor, Dosekun, Olamide, Flamm, Jason, Gallant, Joel, Gerstoft, Jan, Gilson, Richard, Gladstein, Jay, Grant, Robert, Grossberg, Robert, Haas, Bernhard, Halperin, Jason, Hardy, W. David, Hare, Charles, Hassler, Shawn, Hengel, Richard, Henry, William, Hodge, Theo, Jr., Hosek, Sybil, Hurt, Christopher, Iandiorio, Michelle, Jessen, Heiko, Kegg, Stephen, Knecht, Gabriele, Kronborg, Gitte, Krznaric, Ivanka, LaMarca, Anthony, Larsen, Carsten Schade, Larsen, Olav Ditlevsen, Lazzarin, Adriano, Leen, Clifford, Lucasti, Christopher, Mallon, Patrick, Mannheimer, Sharon, Markowitz, Martin, Martorell, Claudia, Mayer, Kenneth, Mills, Anthony, Molina, Jean-Michel, Morris, Sheldon, Mounzer, Karam, Nwokolo, Nneka, Ogbuagu, Onyema, Osiyemi, Olayemi, Petroll, Andrew, Philibert, Patrick, Phoenix, John, Pialoux, Gilles, Podzamczer, Daniel, Post, Frank, Prins, Maria, Ramgopal, Moti, Rashbaum, Bruce, Reeves, Iain, Richmond, Gary, Rieger, Armin, Ruane, Peter, Salazar, Laura, Scarsella, Anthony, Schembri, Gabriel, Scott, Mia, Shalit, Peter, Sinclair, Gary, Sobieszczyk, Magdalena, Spinner, Christoph, Stephens, Jeffrey, Szabo, Jason, Taylor, Stephen, Thompson, Melanie, Tremblay, Cecile, Trottier, Benoit, Voskuhl, Gene, Wade, Barbara, Wohl, David, Workowski, Kimberly, Yawetz, Sigal, Young, Benjamin, Ruane, Peter J, Salazar, Laura C, Henry, Keith, Asmuth, David M, Shao, Yongwu, Ebrahimi, Ramin, Cox, Stephanie, Kintu, Alexander, Carter, Christoph, Das, Moupali, Baeten, Jared M, Brainard, Diana M, Whitlock, Gary, Brunetta, Jason M, and Spinner, Christoph D

Published
2021
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3. Evaluation of oral serum-derived bovine immunoglobulins in HIV-infected patients with chronic idiopathic diarrhea

Author

Asmuth, David M, Hinkle, John E, LaMarca, Anthony, Fichtenbaum, Carl J, Somsouk, Ma, Utay, Netanya S, Shaw, Audrey L, Petschow, Bryon W, Detzel, Christopher J, and Weaver, Eric M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, HIV/AIDS, Digestive Diseases, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Administration, Oral, Adult, Aged, Animals, Cattle, Chronic Disease, Cross-Over Studies, Diarrhea, Double-Blind Method, Drug-Related Side Effects and Adverse Reactions, Female, HIV Infections, Humans, Immunoglobulins, Immunologic Factors, Male, Middle Aged, Placebos, Prospective Studies, Serum, Treatment Outcome, HIV-associated enteropathy, Bovine immunoglobulins, Chronic diarrhea, Safety evaluation, Virology, Clinical sciences
Abstract

Objectives To evaluate serum-derived bovine immunoglobulin/protein isolate (SBI) for safety and impact on gastrointestinal (GI) symptoms in HIV patients with chronic idiopathic diarrhea. Methods A multi-center trial comprised of a double-blind, placebo (PBO)-controlled lead-in phase, (participants received PBO or SBI at 2.5 or 5.0 g BID for 4 weeks) followed by a 20-week, PBO-free phase (SBI at either 2.5 or 5.0 g BID). Participants included HIV-infected patients who were virologically suppressed with a history of chronic idiopathic diarrhea, defined as > 3 loose stools per day for ≥ 3 months without an identifiable cause. Safety was evaluated by monitoring adverse events (AEs) and clinical laboratory testing. Health status and changes in GI symptoms were assessed using validated questionnaires. Results SBI was well tolerated by the 103 participants with only 2 withdrawals due to AEs potentially associated with SBI. Mean number of daily unformed stools decreased from about 4 at baseline to less than 2 by week 4 for all study groups. Improvements in several other GI symptoms were also reported. Comparison of the PBO group to SBI groups showed no significant differences, although both SBI cohorts reported significantly improved health status scores. GI symptom improvements were maintained throughout the 20-week PBO-free phase. Conclusions Oral SBI is safe and well tolerated at the doses studied in HIV patients with chronic diarrhea. No conclusions could be drawn regarding impact on GI symptoms. Additional studies are ongoing to examine the biological and immunologic effects of SBI in virologically suppressed HIV-infected patients.

Published
2017

4. Switching from efavirenz, emtricitabine, and tenofovir disoproxil fumarate to tenofovir alafenamide coformulated with rilpivirine and emtricitabine in virally suppressed adults with HIV-1 infection: a randomised, double-blind, multicentre, phase 3b, non-inferiority study

Author

DeJesus, Edwin, Ramgopal, Moti, Crofoot, Gordon, Ruane, Peter, LaMarca, Anthony, Mills, Anthony, Martorell, Claudia T, de Wet, Joseph, Stellbrink, Hans-Jürgen, Molina, Jean-Michel, Post, Frank A, Valero, Ignacio Pérez, Porter, Danielle, Liu, YaPei, Cheng, Andrew, Quirk, Erin, SenGupta, Devi, and Cao, Huyen

Published
2017
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5. Switching from tenofovir disoproxil fumarate to tenofovir alafenamide coformulated with rilpivirine and emtricitabine in virally suppressed adults with HIV-1 infection: a randomised, double-blind, multicentre, phase 3b, non-inferiority study

Author

Orkin, Chloe, DeJesus, Edwin, Ramgopal, Moti, Crofoot, Gordon, Ruane, Peter, LaMarca, Anthony, Mills, Anthony, Vandercam, Bernard, de Wet, Joseph, Rockstroh, Jürgen, Lazzarin, Adriano, Rijnders, Bart, Podzamczer, Daniel, Thalme, Anders, Stoeckle, Marcel, Porter, Danielle, Liu, Hui C, Cheng, Andrew, Quirk, Erin, SenGupta, Devi, and Cao, Huyen

Published
2017
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15. Amigo: Proximity-Based Authentication of Mobile Devices

Author

Varshavsky, Alex, Scannell, Adin, LaMarca, Anthony, de Lara, Eyal, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Krumm, John, editor, Abowd, Gregory D., editor, Seneviratne, Aruna, editor, and Strang, Thomas, editor

Published
2007
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16. Practical Metropolitan-Scale Positioning for GSM Phones

Author

Chen, Mike Y., Sohn, Timothy, Chmelev, Dmitri, Haehnel, Dirk, Hightower, Jeffrey, Hughes, Jeff, LaMarca, Anthony, Potter, Fred, Smith, Ian, Varshavsky, Alex, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Dourish, Paul, editor, and Friday, Adrian, editor

Published
2006
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17. Mobility Detection Using Everyday GSM Traces

Author

Sohn, Timothy, Varshavsky, Alex, LaMarca, Anthony, Chen, Mike Y., Choudhury, Tanzeem, Smith, Ian, Consolvo, Sunny, Hightower, Jeffrey, Griswold, William G., de Lara, Eyal, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Dourish, Paul, editor, and Friday, Adrian, editor

Published
2006
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19. Mobile Context Inference Using Low-Cost Sensors

Author

Welbourne, Evan, Lester, Jonathan, LaMarca, Anthony, Borriello, Gaetano, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Strang, Thomas, editor, and Linnhoff-Popien, Claudia, editor

Published
2005
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20. Place Lab: Device Positioning Using Radio Beacons in the Wild

Author

LaMarca, Anthony, Chawathe, Yatin, Consolvo, Sunny, Hightower, Jeffrey, Smith, Ian, Scott, James, Sohn, Timothy, Howard, James, Hughes, Jeff, Potter, Fred, Tabert, Jason, Powledge, Pauline, Borriello, Gaetano, Schilit, Bill, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Gellersen, Hans -W., editor, Want, Roy, editor, and Schmidt, Albrecht, editor

Published
2005
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21. Social Disclosure of Place: From Location Technology to Communication Practices

Author

Smith, Ian, Consolvo, Sunny, Lamarca, Anthony, Hightower, Jeffrey, Scott, James, Sohn, Timothy, Hughes, Jeff, Iachello, Giovanni, Abowd, Gregory D., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Gellersen, Hans -W., editor, Want, Roy, editor, and Schmidt, Albrecht, editor

Published
2005
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22. Accurate GSM Indoor Localization

Author

Otsason, Veljo, Varshavsky, Alex, LaMarca, Anthony, de Lara, Eyal, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Beigl, Michael, editor, Intille, Stephen, editor, Rekimoto, Jun, editor, and Tokuda, Hideyuki, editor

Published
2005
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23. Self-Mapping in 802.11 Location Systems

Author

LaMarca, Anthony, Hightower, Jeff, Smith, Ian, Consolvo, Sunny, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Beigl, Michael, editor, Intille, Stephen, editor, Rekimoto, Jun, editor, and Tokuda, Hideyuki, editor

Published
2005
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24. Control, Deception, and Communication: Evaluating the Deployment of a Location-Enhanced Messaging Service

Author

Iachello, Giovanni, Smith, Ian, Consolvo, Sunny, Abowd, Gregory D., Hughes, Jeff, Howard, James, Potter, Fred, Scott, James, Sohn, Timothy, Hightower, Jeffrey, LaMarca, Anthony, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Beigl, Michael, editor, Intille, Stephen, editor, Rekimoto, Jun, editor, and Tokuda, Hideyuki, editor

Published
2005
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25. Learning and Recognizing the Places We Go

Author

Hightower, Jeffrey, Consolvo, Sunny, LaMarca, Anthony, Smith, Ian, Hughes, Jeff, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Beigl, Michael, editor, Intille, Stephen, editor, Rekimoto, Jun, editor, and Tokuda, Hideyuki, editor

Published
2005
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26. Some Assembly Required: Supporting End-User Sensor Installation in Domestic Ubiquitous Computing Environments

Author

Beckmann, Chris, Consolvo, Sunny, LaMarca, Anthony, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Davies, Nigel, editor, Mynatt, Elizabeth D., editor, and Siio, Itiro, editor

Published
2004
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29. Making Sensor Networks Practical with Robots

Author

LaMarca, Anthony, Brunette, Waylon, Koizumi, David, Lease, Matthew, Sigurdsson, Stefan B., Sikorski, Kevin, Fox, Dieter, Borriello, Gaetano, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Mattern, Friedemann, editor, and Naghshineh, Mahmoud, editor

Published
2002
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34. Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Ogbuagu, Onyema, primary, Ruane, Peter J, additional, Podzamczer, Daniel, additional, Salazar, Laura C, additional, Henry, Keith, additional, Asmuth, David M, additional, Wohl, David, additional, Gilson, Richard, additional, Shao, Yongwu, additional, Ebrahimi, Ramin, additional, Cox, Stephanie, additional, Kintu, Alexander, additional, Carter, Christoph, additional, Das, Moupali, additional, Baeten, Jared M, additional, Brainard, Diana M, additional, Whitlock, Gary, additional, Brunetta, Jason M, additional, Kronborg, Gitte, additional, Spinner, Christoph D, additional, Antinori, Andrea, additional, Apea, Vanessa, additional, Asmuth, David, additional, Avery, Ann, additional, Benson, Paul, additional, Bergin, Colm, additional, Berhe, Mezgebe, additional, Brar, Indira, additional, Brinson, Cynthia, additional, Brunetta, Jason, additional, Burack, Jeffrey, additional, Campbell, Thomas, additional, Cespedes, Michelle, additional, Clarke, Amanda, additional, Coleman, Megan, additional, Coll, Josep, additional, Crespo Casal, Manuel, additional, Creticos, Catherine, additional, Crofoot, Gordon, additional, Cruickshank, Frederick, additional, Cua, Eric, additional, Daar, Eric, additional, de Wet, Joseph, additional, DeJesus, Edwin, additional, Del Romero Guerrero, Jorge, additional, Dinges, William, additional, Doblecki-Lewis, Susanne, additional, Donovan, Taylor, additional, Dosekun, Olamide, additional, Flamm, Jason, additional, Gallant, Joel, additional, Gerstoft, Jan, additional, Gladstein, Jay, additional, Grant, Robert, additional, Grossberg, Robert, additional, Haas, Bernhard, additional, Halperin, Jason, additional, Hardy, W. David, additional, Hare, Charles, additional, Hassler, Shawn, additional, Hengel, Richard, additional, Henry, William, additional, Hodge, Theo, additional, Hosek, Sybil, additional, Hurt, Christopher, additional, Iandiorio, Michelle, additional, Jessen, Heiko, additional, Kegg, Stephen, additional, Knecht, Gabriele, additional, Krznaric, Ivanka, additional, LaMarca, Anthony, additional, Larsen, Carsten Schade, additional, Larsen, Olav Ditlevsen, additional, Lazzarin, Adriano, additional, Leen, Clifford, additional, Lucasti, Christopher, additional, Mallon, Patrick, additional, Mannheimer, Sharon, additional, Markowitz, Martin, additional, Martorell, Claudia, additional, Mayer, Kenneth, additional, Mills, Anthony, additional, Molina, Jean-Michel, additional, Morris, Sheldon, additional, Mounzer, Karam, additional, Nwokolo, Nneka, additional, Ogbuagu, Onyema, additional, Osiyemi, Olayemi, additional, Petroll, Andrew, additional, Philibert, Patrick, additional, Phoenix, John, additional, Pialoux, Gilles, additional, Post, Frank, additional, Prins, Maria, additional, Ramgopal, Moti, additional, Rashbaum, Bruce, additional, Reeves, Iain, additional, Richmond, Gary, additional, Rieger, Armin, additional, Ruane, Peter, additional, Salazar, Laura, additional, Scarsella, Anthony, additional, Schembri, Gabriel, additional, Scott, Mia, additional, Shalit, Peter, additional, Sinclair, Gary, additional, Sobieszczyk, Magdalena, additional, Spinner, Christoph, additional, Stephens, Jeffrey, additional, Szabo, Jason, additional, Taylor, Stephen, additional, Thompson, Melanie, additional, Tremblay, Cecile, additional, Trottier, Benoit, additional, Voskuhl, Gene, additional, Wade, Barbara, additional, Workowski, Kimberly, additional, Yawetz, Sigal, additional, and Young, Benjamin, additional

Published
2021
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37. Efficacy and safety of a once-daily fixed-dose combination of abacavir twice daily and lamivudine once daily as separate entities in antiretroviral-experienced HIV-1-infected patients (CAL3001 study)

Author

LaMarca, Anthony, Clumeck, Nathan, Plettenberg, Andreas, Domingo, Pere, Kaisong Fu, Craig, Charles, Zhao, Henry, Watson, Maria, Gordon, David, and Scott, Trevor

Subjects
Abacavir -- Dosage and administration, Abacavir -- Comparative analysis, Lamivudine -- Dosage and administration, Lamivudine -- Comparative analysis, HIV infection -- Drug therapy, Tenofovir -- Dosage and administration, Tenofovir -- Comparative analysis, Antiviral agents -- Dosage and administration, Antiviral agents -- Comparative analysis, Health
Abstract

A study to compare the efficacy and safety of the fixed-dose combination group to the separate entities group, in combination with tenofovir and a new protease inhibitor or nonnucleoside reverse transcription inhibitor in antiretroviral-experienced adults experiencing virologic failure is illustrated. Combination antiretroviral therapy has dramatically reduced the morbidity and mortality associated with HIV infection and a one-tablet, once-daily abacavir/lamivudine (FDC) has been recently approved to treat HIV-1 infection.

Published
2006

42. Designing an augmented writing surface

Author

Mynatt, Elizabeth, Takedo Igarashi, Edwards, W. Keith, and LaMarca, Anthony

Subjects
Computer graphics -- Innovations, Office equipment and supplies -- Innovations
Published
2000

47. A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome

Author

Pierce, Mark, Crampton, Sheri, Henry, David, Heifets, Leonid, LaMarca, Anthony, Montecalvo, Marisa, Wormser, Gary P., Jablonowski, Helmut, Jemsek, Joseph, Cynamon, Michael, Yangco, Bienvenido G., Notario, Gerard, and Craft, J. Carl

Subjects
Mycobacterial infections -- Drug therapy, Clarithromycin -- Evaluation, Mycobacterium avium complex
Abstract

The antibiotic clarithromycin seems to be effective in preventing Mycobacterium avium complex infections in AIDS patients. Of 677 AIDS patients with no history of this opportunistic infection, 333 began taking clarithromycin and 334 began taking a placebo. Only 19 (6%) of those taking clarithromycin developed the infection, compared to 53 (16%) of those taking placebo. Clarithromycin reduced the mortality rate by 25% during the 10-month follow-up. Eleven of the 19 patients taking clarithromycin who developed the infection had a drug-resistant strain.

Published
1996

49. Delivering real-world ubiquitous location systems

Author

Borriello, Gaetano, Chalmers, Matthew, LaMarca, Anthony, and Nixon, Paddy

Subjects
Wireless technology, Global Positioning System, Mobile communication systems -- Social aspects, Wireless communication systems -- Social aspects, Global Positioning System -- Analysis, Electronics in navigation -- Analysis
Published
2005

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