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Your search keyword '"LaMantia, L."' showing total 16 results
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16 results on '"LaMantia, L."'

4. Endovascular treatment of CCSVI in patients with multiple sclerosis: clinical outcome of an Italian cohort of 462 cases

Author

Ghezzi, A., Annovazzi, P. O., Amato, M. P., Balgera, R., Banfi, P., Bartolozzi, M. L., Bergamaschi, R., Bertolotto, A., Bianchi, A., Bosco, A., Capello, E., Capobianco, M., Capra, R., Cavalla, P., Clerici, R., Coarelli, Giulia, Cocco, E., De Rossi, N., Tillio Di, C., Ferro, M. T., Gallo, A., Gallo, P., Lamantia, L., Lugaresi, A., Lus, G., Malucchi, S., Moiola, L., Provinciali, L., Patti, F., Perini, P., Perrone, P., Protti, A., Rodegher, M. E., Rossi, P., Rottoli, M., Rovaris, M., Salemi, G., Salvetti, Marco, Simone, I., Tola, M. R., Trojano, M., Vitetta, F., Marrosu, M. G., Comi, G., Study Group, M. S., Neurology, Italian Society O. F., and Italian Society Ofneurology

Published
2012

13. MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis

Author

Paola Tortorella, Angelo Ghezzi, Loredana Lamantia, Massimo Filippi, Maria A. Rocca, Domenico M. Mezzapesa, Giancarlo Comi, Tortorella, P, Rocca, Ma, Mezzapesa, Dm, Ghezzi, A, Lamantia, L, Comi, G, and Filippi, Massimo

Subjects
Male, Pathology, medicine.medical_specialty, Neurology, Multiple Sclerosis, Adolescent, Population, Nerve Fibers, Myelinated, Central nervous system disease, White matter, Predictive Value of Tests, Neural Pathways, medicine, Humans, Gliosis, Age of Onset, Sex Distribution, education, Child, Neuroradiology, education.field_of_study, medicine.diagnostic_test, business.industry, Multiple sclerosis, Brain, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Diffusion Magnetic Resonance Imaging, Disease Progression, Female, Neurology (clinical), Nuclear medicine, business, Wallerian Degeneration, Diffusion MRI
Abstract

Contrary to what happens in adult-onset multiple sclerosis (MS), in a previous preliminary magnetic resonance imaging (MRI) study we showed only subtle normal-appearing brain tissue changes in patients with earlyonset MS. Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS.Using diffusion tensor (DT) and magnetization transfer (MT) MRI, we obtained DT and MT ratio (MTR) maps of the NAWM and GM from 23 patients with early-onset MS and 16 sex- and age-matched healthy volunteers.Compared with healthy volunteers, patients with early-onset MS had significantly increased average MD (p = 0.02) and FA peak height (p = 0.007) and decreased average FA (p0.0001) of the NAWM. Brain dual-echo lesion load was significantly correlated with average FA (r = -0.48, p = 0.02) and with FA peak height (r = 0.45, p = 0.03) of the NAWM. No MTR and diffusion changes were detected in the GM.This study confirms the paucity of the 'occult' brain tissue damage in patients with earlyonset MS. It also suggests that in these patients GM is spared by the disease process and that NAWM changes are likely to be secondary to Wallerian degeneration of fibers passing through macroscopic lesions.

Published
2006

14. CSF T-cell subsets in multiple sclerosis: relationship to cerebrospinal fluid myelin basic protein and clinical activity.

Author

Salmaggi A, LaMantia L, Milanese C, Bianchi G, Eoli M, Campi A, and Nespolo A

Subjects
Adolescent, Adult, CD4-Positive T-Lymphocytes immunology, Cerebrospinal Fluid cytology, Child, Female, Humans, Male, Middle Aged, Multiple Sclerosis cerebrospinal fluid, Nervous System Diseases cerebrospinal fluid, Nervous System Diseases immunology, T-Lymphocytes, Regulatory immunology, Multiple Sclerosis immunology, Myelin Basic Protein cerebrospinal fluid, T-Lymphocytes immunology
Abstract

Cerebrospinal fluid myelin basic protein and cerebrospinal fluid and peripheral blood T-cell subsets have been studied in patients with multiple sclerosis and other inflammatory and non-inflammatory nervous system diseases. These biological parameters have been correlated with clinical disease activity. No changes in peripheral blood T-cell subsets were seen in multiple sclerosis patients. Low cerebrospinal fluid T8+ cells occurred only in multiple sclerosis, while high cerebrospinal fluid T4+ cells were detected both in clinically active multiple sclerosis and in inflammatory nervous system diseases. A close relationship was found between cerebrospinal fluid T4/T8 ratio and myelin basic protein in relapsing multiple sclerosis patients.

Published
1989
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