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711 results on '"La Vignera, S."'

7. SARS-CoV-2 infection, male fertility and sperm cryopreservation: a position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) (Società Italiana di Andrologia e Medicina della Sessualità)

Author

Corona, G., Baldi, E., Isidori, A. M., Paoli, D., Pallotti, F., De Santis, L., Francavilla, F., La Vignera, S., Selice, R., Caponecchia, L., Pivonello, R., Ferlin, A., Foresta, C., Jannini, E. A., Lenzi, A., Maggi, M., and Lombardo, F.

Published
2020
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9. Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE)

Author

Caprio, M., Infante, M., Moriconi, E., Armani, A., Fabbri, A., Mantovani, G., Mariani, S., Lubrano, C., Poggiogalle, E., Migliaccio, S., Donini, L. M., Basciani, S., Cignarelli, A., Conte, E., Ceccarini, G., Bogazzi, F., Cimino, L., Condorelli, R. A., La Vignera, S., Calogero, A. E., Gambineri, A., Vignozzi, L., Prodam, F., Aimaretti, G., Linsalata, G., Buralli, S., Monzani, F., Aversa, A., Vettor, R., Santini, F., Vitti, P., Gnessi, L., Pagotto, U., Giorgino, F., Colao, A., and Lenzi, A.

Published
2019
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11. Diagnostica genetica dell’infertilità maschile: nuovi approcci

Author

Calogero, Ae, La Vignera, S, and Condorelli, Ra

Subjects
NGS, Genetica, Alterazioni della spermatogenesi, Infertilità, Oligozoospermia
Abstract

SommarioL’infertilità maschile, caratterizzata dall’alterazione dei parametri spermatici convenzionali e/o biofunzionali, viene riscontrata, da sola o in associazione con quella femminile, in circa il 50% dei casi di infertilità di coppia. Una causa genetica si riscontra in circa il 15% dei pazienti con azoospermia o oligozoospermia. Nonostante un approccio diagnostico approfondito, si stima però che la causa dell’infertilità rimane sconosciuta in una grande percentuale dei partner maschili delle coppie infertili. Recentemente, alcune evidenze hanno suggerito l’esistenza di nuove cause genetiche responsabili di alterazioni della spermatogenesi. Lo scopo di questa Rassegna è quello di valutare le evidenze relative alle alterazioni della spermatogenesi di natura genetica, rivedendo i dati disponibili sia nei modelli animali che nell’uomo. I dati di tale revisione della letteratura ci hanno permesso di suggerire l’uso di un pannello che comprende oltre 60 geni nell’iter diagnostico dei pazienti con alterazioni dei parametri spermatici di natura idiopatica. Alcuni di questi geni sembrerebbero associarsi a uno specifico quadro istologico testicolare. Se confermate, queste evidenze potrebbero in futuro avere un ruolo importante nell’iter decisionale relativo alla gestione del paziente infertile.

Published
2022

13. Effects of oral contraceptives on thyroid function and vice versa

Author

Torre, F., Calogero, A. E., Condorelli, R. A., Cannarella, R., Aversa, A., and La Vignera, S.

Abstract

Background: Thyroid gland dysfunction represents an epidemiologically relevant disease in the female gender, where treatment with oral contraceptives (OCs) is frequently prescribed. Although OCs are able to impact the thyroid gland function, scanty data have been released on this matter so far. Aim: The aim of this article was to review how hormonal OCs, including estrogen- or progesterone-only containing medications, interact with the hepatic production of thyroid-binding globulin (TBG) and, consequently, their effects on serum levels of thyroxine (T4) and triiodothyronine (T3). We also reviewed the effect of Levo-T4 (LT4) administration in women taking OCs and how they influence the thyroid function in both euthyroid women and in those receiving LT4. Review: The estrogenic component of the pills is capable of increasing various liver proteins, such as TBG, sex hormone-binding protein (SHBG) and coagulation factors. On the other hand, the role of progestogens is to modulate estrogen-dependent effects mainly through their anti-androgenic action. In fact, a reduction in the effects of androgens is useful to keep the thromboembolic and cardiovascular risks low, whereas OCs increase it especially in women with subclinical hypothyroidism or in those treated with LT4. Accordingly, subclinical hypothyroidism is known to be associated with a higher mean platelet volume than normal and this increases cardiovascular risk due to platelet hyperactivity caused by incomplete thrombocytopoietic maturation.

Published
2024
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16. Male accessory gland infection: diagnosis and treatment

Author

Cannarella, R., Condorelli, R. A., Cimino, L., Mongioi, L. M., Compagnone, M., Barbagallo, F., Crafa, A., Calogero, A. E., and La Vignera, S.

Subjects
Antibiotics, Oxidative stress, Infertility, Male accessory gland infection, Antioxidants
Published
2023

30. The possible role of SARS-CoV-2 in male fertility

Author

Leanza, C, Mongioì, Lm, Cannarella, R, La Vignera, S, Condorelli, Ra, and Calogero, Ae

Subjects
SARS-CoV-2, male reproductive system, sperm parameters, COVID-19, male infertility
Published
2022

38. Overexpression of p75NTR in Testicular Germ Cell Tumors: a New Biomarker of Cancer Differentiation?

Author

Antonio Aversa, La Vignera S, Margherita Vergine, Maltese L, Malivindi R, Eusebio Chiefari, Tucci L, Danilo Lofaro, Antonio Brunetti, Anna Perri, Rago, Renzo Bonofiglio, and Emanuela Greco

Subjects
business.industry, medicine, Cancer research, Cancer, Biomarker (medicine), endocrinology_metabolomics, sense organs, medicine.disease, business, Testicular germ cell
Abstract

Several studies have demonstrated that the p75NTR low-affinity receptor of Nerve Growth Factor (NGF), is produced in abnormally large amounts in several human cancer types. However, the role of p75NTR varies substantially depending on cell context, so that a dual role of this receptor protein in tumor cell survival and invasion, as well as cell death, has been supported in recent studies. Herein we explored for the first time the expression of p75NTR in human specimens (nr=40) from testicular germ cell tumors (TGCTs), mostly seminomas. Nuclear overexpression of p75NTR was detected by immunohistochemistry in tumor tissue as compared to normal tissue, whereas neither NGF nor its high-affinity TrkA receptor was detected. An increased nuclear staining of phospho-JNK, belonging to the p75NTR signaling pathway, and its pro-apoptotic target gene, p53, was concomitantly observed. Interestingly, our analysis revealed that decreased expression frequency of p75NTR, p-JNK, and p53 was related to staging progression, thus suggesting that p75NTR may represent a specific marker of differentiation in TGCTs.

Published
2021

42. Anti-Müllerian Hormone, Growth Hormone, and Insulin-Like Growth Factor 1 Modulate the Migratory and Secretory Patterns of GnRH Neurons

Author

Cannarella, R., Paganoni, A. J. J., Cicolari, S., Oleari, R., Condorelli, R. A., La Vignera, S., Cariboni, A., Calogero, A. E., and Magni, P.

Subjects
Anti-Mullerian Hormone, Neurons, endocrine system, Cultured, Human Growth Hormone, Cells, IGF1, hypogonadotropic hypogonadism, GnRH secretion, Article, GH, lcsh:Chemistry, neuron migration, Gonadotropin-Releasing Hormone, Mice, lcsh:Biology (General), lcsh:QD1-999, Cell Movement, GnRH, AMH, Animals, Insulin-Like Growth Factor I, lcsh:QH301-705.5, hormones, hormone substitutes, and hormone antagonists, Cells, Cultured
Abstract

Anti-Müllerian hormone (AMH) is secreted by Sertoli or granulosa cells. Recent evidence suggests that AMH may play a role in the pathogenesis of hypogonadotropic hypogonadism (HH) and that its serum levels could help to discriminate HH from delayed puberty. Moreover, the growth hormone (GH)/insulin-like growth factor 1 (IGF1) system may be involved in the function of gonadotropin-releasing hormone (GnRH) neurons, as delayed puberty is commonly found in patients with GH deficiency (GHD) or with Laron syndrome, a genetic form of GH resistance. The comprehension of the stimuli enhancing the migration and secretory activity of GnRH neurons might shed light on the causes of delay of puberty or HH. With these premises, we aimed to better clarify the role of the AMH, GH, and IGF1 on GnRH neuron migration and GnRH secretion, by taking advantage of previously established models of immature (GN11 cell line) and mature (GT1-7 cell line) GnRH neurons. Expression of Amhr, Ghr, and Igf1r genes was confirmed in both cell lines. Cells were then incubated with increasing concentrations of AMH (1.5–150 ng/mL), GH (3–1000 ng/mL), or IGF1 (1.5–150 ng/mL). All hormones were able to support GN11 cell chemomigration. AMH, GH, and IGF1 significantly stimulated GnRH secretion by GT1-7 cells after a 90-min incubation. To the best of our knowledge, this is the first study investigating the direct effects of GH and IGF1 in GnRH neuron migration and of GH in the GnRH secreting pattern. Taken together with previous basic and clinical studies, these findings may provide explanatory mechanisms for data, suggesting that AMH and the GH-IGF1 system play a role in HH or the onset of puberty.

Published
2021

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