3 results on '"La Terra, Antonio"'
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2. Global trends in opioid use for pain management in acute pancreatitis: A multicentre prospective observational study
- Author
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Knoph, Cecilie Siggaard, Lucocq, James, Kamarajah, Sivesh Kathir, Olesen, Søren Schou, Jones, Michael, Samanta, Jayanta, Talukdar, Rupjyoti, Capurso, Gabriele, de‐Madaria, Enrique, Yadav, Dhiraj, Siriwardena, Ajith K., Windsor, John, Drewes, Asbjørn Mohr, Nayar, Manu, Cark, Neil, Pius, Riinu, Houghton, Eduardo, Gimenéz, Mariano, Uribe, Karla, Rodriguez, Florencia, Gundara, Justin, Mackay, Thomas, Phan, Huynh, Lewin, Joel, McElhatton, Claire, Siriwardhane, Mehan, Hodgson, Russell, Malik, Hassan, Ward, Ryan, Young, Kerilee, Bappayya, Shaneel, Loveday, Benjamin, Samra, Jaswinder, Gall, Tamara, Mittal, Anubhav, Chan, Ting Ting, Lo, Vincent Wing‐ho, Liang, Hui, Wang, Cong, Huang, Wei, Jin, Tao, Wu, Yongzi, Xia, Qing, Georgio, Nikolaou, Koronakis, Nikolaos, Davidsen, Line, Hamed, Emad, Mohamed, Salem, Demetrashvili, Zaza, Tvaladze, Ana, Kachakhidze, Irakli, Zurabashvili, Tea, Ioannidis, Orestis, Kapiris, Stylianos, Mavrodimitraki, Eleni, Sotiropoulou, Maria, Machairas, Nikolaos, Schizas, Dimitrios, Syllaios, Athanasios, Vailas, Michail, Chlorakis, Georgios, Kalaitzakis, Evangelos, Tsafaridou, Maria, Mulita, Francesk, Verras, Georgios‐Ioannis, Gupta, Amit, Rajput, Deepak, Sharma, Oshin, Goud, Rajesh, Unnisa, Misbah, Bains, Lovenish, Singh, Nishu, Dhar, Jahnvi, Abdelmoeti, Mahmoud, Súilleabháin, Criostóir Ó, O'Connell, Robert, Calabro, Marcello, La Terra, Antonio, Muretore, Andrea, Contul, Riccardo Brachet, Diotallevi, Margherita, Mascaro, Annamaria, Millo, Paolo, Biondo, Santino Antonio, Mazzeo, Carmelo, Cucinotta, Eugenio, Fleres, Francesco, Marinak, AOUG, Brocco, Veronica, Ceresoli, Marco, Rennis, Maria, Centonze, Danilo, Distefano, Coatanza, Veroux, Massimiliano, Zerbo, Domenico, Bogoni, Selene, Biloslavo, Alan, Bianchi, Velentina, Candelli, Marcello, Franceschi, Francesco, Gasbarrini, Antonio, Nista, Enrico, Sganga, Gabriele, Tropeano, Giuseppe, Policlinico, Fondazione, Altieri, Caterina, Dinuzzi, Vincenza, Marconi, Matteo, Rivolta, Umberto, Dameno, Vitale Roberto, Papa, Mario V., Balla, Andrea, Lepiane, Pasquale, Saraceno, Federica, Aiolfi, Alberto, Bona, Davide, Sozzi, Andrea, Cianci, Pasquale, Varesano, Marco, Conversano, Ivana, Abete, Roberta, D'Avino, Raffaele, Marra, Ester, Marte, Gianpaolo, Tammaro, Pasquale, Gobatti, Davide, Marmaggi, Serena, Palmieri, Francesco, Sampietro, Roberto, Manca, Roberto, Pilla, Federica, Piras, Enrico, Pignata, Giusto, Canfora, Ilaria, Andreuccetti, Jacopo, D'Alessio, Rossella, Armellin, Claudia, Grossi, Ugo, Massani, Marco, Pontin, Alessandro, Stecca, Tommaso, Pilia, Tiaizna, Pisanu, Adolfo, Podda, Mauro, Giuffrida, Mario, Perrone, Gennaro, Guadagni, Simone, Morelli, Luca, Frontali, Alice, Basurto, Francesca, D'Ugo, Stefano, Manoochehri, Farshad, Spampinato, Marcello, Apadula, Laura, Preatoni, Paoletta, Sartarelli, Lodovico, Al‐Jaiuossi, Osama, Ernisova, Mairam, Sopuev, Andrey, Sua, Bruce, Farfus, Anthony, Teo, Keith, Smith, Brittany, Ratnayake, Bathiya, Buchanan, Jayvee, Clark, Elinor, Connor, Saxon, Hore, Todd, Attari, Salman, Kadir, Bushra, Memon, Sadik, Abbas, Zaigham, Quadeer, Muhammad Ali, Altaf, Abeer, Ameet, Pooja, Devi, Jalpa, Seerani, Nandlal, Afzal, Ameer, Akbar, Ali, Asghar, Mohammad Sohail, Sa, Tiago, Barreira, Ana Lucia, Carvalho, Numo, Cismasiu, Brigitta, Henriques, Susana, Luiz, Francisco Vara, Draghici, Andreea, Grigorean, Valentin, Porojan, Vlad, Stoian, Alexandru‐Rares, Teaca, Lucia, Arbutina, Dragana, Cuk, Vladica, Kovacevic, Bojan, Mandic, Luka, Bonney, Glenn, Gao, Yujia, Pang, Ning Qi, Bellil, Abdalla, Devar, John, Khan, Zafar, Khumalo, Vusi, Smith, Martin, Estevez‐Fernandez, Sergio, Mosquera, Beatriz Romero, Rodriguez, Sergio, Garcia‐Rayado, Guillermo, Piñerua‐Gonsalvez, Jean Felix, Ruiz Rebollo, M Lourdes, Olmos, Jose M., Tejedor‐Tejada, Javier, Diez‐Alonso, Manuel, Matias‐Garcia, Belen, Moreno, Fernando Mendoza, Vera‐Mansilla, Cristina, Roses, Helena Salvador, Gómez, Diego Vázquez, Oballe, Juan Rodriguez, Jayarajah, Umesh, Nandasena, Malith, Pathirana, Aloka, Galal‐Eldin, Sami, Hajibandeh, Shahab, Hamid, Hytham, Colak, Elif, Sydorchuk, Larysa, Knut, Ruslan, Voronyuk, Ksenia, Chooklin, Serge, Baryskyi, Vitalii, Sydorchuk, Ruslan, Mukherjee, Samrat, Patel, Maitreyi, Akhtar, Amina, Asarbakhsh, Miriam, Nolan, Frances, Schuijtvlot, Nicholaas, Prem, Sandhya, Thrikandiyur, Anuradha, Morris, Millicent, Mroczek, Thomas, Sgourakis, George, Sultana, Asma, Varley, Rebecca, Groot‐Wassink, Thomas, Labinoti, Roland, Packham, Brett, Seebah, Keving, Allen, Sophie, Mokhtassi, Shiva, Belgaumkar, Ajay, De'Ath, Henry, Cook, Amy, Delaney, Christopher, Johnson, Roisin, Azibaodinami, Becky Olali, Sartini, Ashley, Stanfield, Mea, Tomasi, Ivan, Kanakala, Venkat, Mbarushimana, Simon, McKeever, Mark, Batilli, Mamata, Bhatta, Gakul, Rai, Subash, Bond‐smith, Giles, Elserafy, Amr, Shams, Mohamed, Al Saoudi, Tareq, Bhardwaj, Neil, Hussain, Wajith, Lancellotti, Francesco, Montagnini, Greta, Cairns, George, Hollyman, Marianne, Rakin, Asef, Shahid, Mishal, Barbour, Fraser, Hawkyard, Jake, McTeer, Matthew, Pandanaboyana, Sanjay, Taylor, Ellie, Kuzman, Matta, Dyer, Sarah, Hopkins, James, Pournaras, Dimitri, Sudlow, Alexis, Kumar, SK, Aujayeb, Avinash, Leo, Alex, Senra, Fatima Lorenzana, Watfah, Josef, Barrie, Jenifer, Brown, Chris, Gomez, Dhanny, Aroori, Somaiah, Ciprani, Debora, Karmarkar, Rahi, Almomani, Eyas, Roberts, Keith, Fale, Madeleine, Gupta, Ajay, Marsden, Max, Seet, Chris, Soni, Lakshya, Hamdan, Mohammed, Sadera, Rohan, Sud, Vikas, Chinnah, Edith, Di Mauro, Davide, Manzelli, Antonio, Orabi, Amira, Presa, Roberto, Reece‐Smith, Alex, Wajed, Shahjehan, Fingret, Jacob, Shah, Nehal, Jatania, Jignesh, Krishna, Arun, Berry, David, Kitsikosta, Loukiani, Helliwell, Jack, Huntley, Benjamin, Pine, James, Yau, Jih‐Dar, Lee, Shiela, Mahawar, Kamal, Shetty, Neehar, Britton, Emily, Shaw, Alice, Laarhoven, Stijn, Gahunia, Sukhpreet, Ortega, Miguel Gargia, Lee, Adam, Ng, Cho Ee, El Kafsi, Jihene, Mason, John, Vithlani, Gauri, Benhmida, Rami, Gunell, James, Parmar, Chetan, Dorkeh, Da‐Costa, Elnagar, Mohamed, Lee, Jih Ian, Nessa, Ashrafun, Yeap, Zhu Hui, Hemadasa, Niroshini, Javed, Saria, Sami, Sharuk, Damaskos, Dimitrios, Healey, Andrew, Soupashi, Maria, Triantafyllou, Tania, Coats, Maria, Douglass, Benjamin, Hendry, Brid, Hussain, Yasmin, Javid, Zhara, Mantyla, Mia, Rajkumar, Khaman, Chin, Carven, Hajibandeh, Shahab, Kumar, Nagappan, Gerogiannis, Ioannis, Kapsampelis, Panagiotis, Gerge, Farid, Anderson, Gulsum, Dinh, Vu, Phillips, Anna, Yadav, Dhiraj, and Pandanaboyana, Sanjay
- Abstract
Since there is no current international consensus on the optimal approach for pain management in acute pancreatitis (AP), analgesic practices may vary across different healthcare settings. This study explored global disparities in analgesic use, in particular opioids, during admission and at discharge in hospitalised AP patients. This was a post hoc analysis of the prospective PAINAP database, which included all admissions for AP between April and June 2022 with a 1‐month follow‐up. Demographic details, analgesic use, and clinical outcomes were recorded during admission and at discharge. Odds ratios (ORs) for opioid use during admission and at discharge were identified using multivariable regression analyses. Amongst the 1864 patients (52% males, median age 56 (interquartile range, 41–71)) across three different continents, simple analgesics were predominantly used as the primary analgesic (70%). Opioid use during admission was lowest in European centres (67%). Admission in Asian (OR, 2.53 (95% confidence interval (CI), 1.59–4.04), p< 0.001), and Australian (OR, 5.81 (95% CI, 3.19–10.56), p< 0.001) centres was associated with opioid administration during admission compared with European centres. Increased pain severity, longer pre‐admission pain duration, organ failure, and longer length of admission increased opioid use during admission. At discharge, Asian (OR, 2.01 (95% CI, 1.40–2.88), p< 0.001) and Australian (OR, 1.91 (95% CI, 1.28–2.85), p= 0.002) centres were associated with opioid prescription compared with European centres. Increased pain severity, longer pre‐admission pain duration, acute necrotic collections, and walled‐off necrosis also increased the likelihood of opioid prescription at discharge. There are substantial intercontinental differences in opioid use for AP pain. Accordingly, there is a need for international guidelines on pain management in AP.
- Published
- 2024
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3. Predictive Factors and Risk Model for Positive Circumferential Resection Margin Rate after Transanal Total Mesorectal Excision in 2653 Patients with Rectal Cancer
- Author
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S X, Roodbeen, F B, Lacy, S, Dieren, M, Penna, F, Ris, B, Moran, P, Tekkis, W A, Bemelman, R, Hompes, Adamina, Michel, Aigner, Felix, Al Furajii, Hazar, Albers, Benjamin, S Allison, Andrew, Arezzo, Alberto, J Arnold, Steven, Aryal, Kamal, Atallah, Sam, Austin, Ralph, Khurrum Baig, Mirza, Baloyiannis, Ioannis, Bandyopadhyay, Dibyendu, Banerjee, Saswata, Banky, Balazs, Baral, Joerg, Belgers, Eric, Bell, Stephen, Berti, Stefano, Biebl, Matthias, Bloemendaal, Bobby, Boni, Luigi, Bordeianou, Liliana, Borreca, Dario, I Bosker, Robbert J., Box, Benjamin, Boyce, Stephen, Bravo, Raquel, Den Broeck, Sylvie, Brown, Carl, Bruegger, Lukas, Brunner, Walter, Buchli, Christian, C Buchs, Nicolas, Buia, Alexander, Burt, Caroline, Cahill, Ronan, Pablo Campana, Juan, Campbell, Kenneth, Di Candido, Francesca, T Capolupo, Gabriella, Caricato, Marco, Caro-Tarrago, Aleidis, Cassinotti, Elisa, Caycedo, Antonio, Chandrasinghe, Pramodh, Chaudhri, Sanjay, Chernyshov, Stanislav, Chitsabesan, Praminthra, Christoforidis, Dimitri, A Clark, David, Coget, Julien, D Courtney, Edward, Cunningham, Chris, D’hooge, Pieter, D’hoore, Andre, Dagbert, Francois, J Dalton, Stephen, Dapri, Giovanni, Dawson, Robin, Dayal, Sanjeev, Delgado, Salvadora, Delrio, Paolo, Doerner, Johannes, Doornebosch, Pascal, Duff, Sarah, Erkinovich Dzhumabaev, Khasan, Edwards, Tom, Egenvall, Monika, Ravn Eriksen, Jens, Espin, Eloy, Estevez-Schwarz, Lope, Faes, Seraina, Fearden, Arne, Feleppa, Cosimo, Forgan, Tim, Forsmo, Havard, K Francis, Nader, Frontali, Alice, Fu, Cherylin, Gamage, Bawantha, Ignacio Rodriguez Garcia, Jose, Geissmann, Daniel, Geluwe, Bart, Gill, Kathryn, Glockler, Markus, Gloor, Severin, Javier Gomez, Carlos, Graaf, Eelco, Grolich, Tomas, Guido, Jutten, Hahnloser, Dieter, Hance, Julian, Harikrishnan, Athur, Haunold, Ingrid, Hayes, Julian, Hendrickx, Tom, Heriot, Alexander, Hoffmann, Theo-Julian, Hongwei, Yao, Huang, Joe, James, Horwood, Ial, Roshan, Ito, Masaaki, Janssens, Marc, Joy, Howard, Pagin Sao Juliao, Guilherme, Karimuddin, Ahmer, Katory, Mark, Killeen, Shane, Werner Kneist, Knol, Joep, Komen, Niels, Kukreja, Neil, Kusters, Miranda, Lacy, Antonio, Lakatos, Lorand, Lambrechts, Anton, Alvarez Laso, Carlos, Leao, Pedro, Lezoche, Emanuele, A Liberman, Sender, Lidder, Paul, Andrade Lima, Meylina, Lorenzon, Laura, Mackey, Paul, Maggiori, Leon, Zaur Mamedli, Zaman, Mansfield, Steve, Marcoen, Steven, Marcy, Tobias, Maroon, Tohmeh, Marta Pascual, Damieta, Marti, Lukas, Maslekar, Sushil, Mccallum, Iain, Mccarthy, Kathryn, Ramon Silveira Mendes, Carlos, Merrie, Arend, Michalopoulos, Antonios, Mikalauskas, Saulius, F Miles, Anthony W., C Mills, Sarah, Miroshnychenko, Yevgen, Mittermair, Christof, Molloy, Richard, Montroni, Isacco, Moore, Etienne, Moore, Tim, Mooslechner, Barbara, Morino, Mario, Moslein, Gabriela, Muratore, Andrea, Metodiev Mutafchiyski, Ventsislav, Myers, Alistair, Nicol, Deborah, Nieuwenhove, Yves, Nishizaki, Daisuke, John Nolan, Gregory, Ochsner, Alex, Hwan Oh, Jae, Collera Ormazabal, Pablo, Otero, Ana, Ouro, Susana, Panis, Yves, Papavramidis, Theodosios, Papen, Michael, Paraoan, Marius, Pastor, Carlos, Pastor, Enrique, Penchev, Dimitar, Pera, Miguel, Karim Perdawood, Sharaf, Oliva Perez, Rodrigo, Persiani, Roberto, Pfeffer, Frank, Terry Phang, P., Pichetto, Andrea, Pirenne, Yves, Pockney, Peter, Pooter, Karl, Poskus, Eligijus, Pros, Imma, Rajendran, Nirooshun, J Raval, Manoj, Rega, Daniela, Ricciardi, Rocco, Riel, Wouter, Ris, Frederic, Riss, Stefan, Alexander Rockall, Timothy, Romagnolo, Luis, Manuel Romero-Marcos, Juan, Roquete, Paulo, Rossi, Gustavo, Gomez Ruiz, Marcos, Rybakov, Evgeny, Sakai, Yoshiharu, Scala, Andrea, Millan Scheiding, Monica, Monica Millan, Gerald, Seva-Pereira, Gustavo, Sguinzi, Raffaella, A Shaikh, Irshad, Shalaby, Mostafa, Sharma, Abhiram, Sietses, Colin, Sileri, Pierpaolo, Simo, Vicente, Singh, Baljit, Slesser, Alistair, Kyung Sohn, Dae, Sosef, Meindert, Soravia, Claudio, Speakman, Christopher, Spinelli, Antonino, Sprundel, Frank, Steenkiste, Franky, L Stevenson, Andrew R., Stift, Anton, Storms, P., Studer, Peter, Konraad Talsma, Aaldert, J Tanis, Pieter, Tejedor, Patricia, La Terra, Antonio, Torkington, Jared, Jimenez Toscano, Marta, Tschann, Peter, Tuech, Jean-Jacques, Tuynman, Jurriaan, Tzovaras, George, Ugolini, Giampaolo, Vallribera, Francesc, Vanrykel, Filip, Vorburger, Stephan, Warner, Michael, J Warren, Oliver, Warrier, Satish, Warusavitarne, Janindra, Wegstapel, Henk, Weiss, Helmut, Witzig, Jacques-Alain, Wolff, Torsten, Wolthuis, Albert, Wu, Linus, Wynn, Greg, Zhongtao, Zhang, Zingg, Urs, Ziyaie, Dorin, Graduate School, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, Surgery, APH - Methodology, and International TaTME Registry Collaborative
- Subjects
Male ,Colorectal cancer ,registry ,circumferential resection margin ,rectal cancer ,risk factors ,transanal total mesorectal excision ,Adenocarcinoma ,Aged ,Cohort Studies ,Disease-Free Survival ,Endoscopic Mucosal Resection ,Female ,Follow-Up Studies ,Humans ,Length of Stay ,Logistic Models ,Middle Aged ,Multivariate Analysis ,Operative Time ,Predictive Value of Tests ,Proctectomy ,Prognosis ,Prospective Studies ,Rectal Neoplasms ,Registries ,Risk Assessment ,Survival Analysis ,Transanal Endoscopic Surgery ,Treatment Outcome ,Margins of Excision ,0302 clinical medicine ,Prospective cohort study ,ddc:617 ,integumentary system ,Incidence (epidemiology) ,food and beverages ,Total mesorectal excision ,030220 oncology & carcinogenesis ,Predictive value of tests ,embryonic structures ,030211 gastroenterology & hepatology ,Risk assessment ,Cohort study ,medicine.medical_specialty ,animal structures ,03 medical and health sciences ,medicine ,Survival analysis ,business.industry ,fungi ,medicine.disease ,Surgery ,Human medicine ,business - Abstract
Objective: The aim of this study was to determine the incidence of, and preoperative risk factors for, positive circumferential resection margin (CRM) after transanal total mesorectal excision (TaTME). Background: TaTME has the potential to further reduce the rate of positive CRM for patients with low rectal cancer, thereby improving oncological outcome. Methods: A prospective registry-based study including all cases recorded on the international TaTME registry between July 2014 and January 2018 was performed. Endpoints were the incidence of, and predictive factors for, positive CRM. Univariate and multivariate logistic regressions were performed, and factors for positive CRM were then assessed by formulating a predictive model. Results: In total, 2653 patients undergoing TaTME for rectal cancer were included. The incidence of positive CRM was 107 (4.0%). In multivariate logistic regression analysis, a positive CRM after TaTME was significantly associated with tumors located up to 1 cm from the anorectal junction, anterior tumors, cT4 tumors, extra-mural venous invasion (EMVI), and threatened or involved CRM on baseline MRI (odds ratios 2.09, 1.66, 1.93, 1.94, and 1.72, respectively). The predictive model showed adequate discrimination (area under the receiver-operating characteristic curve >0.70), and predicted a 28% risk of positive CRM if all risk factors were present. Conclusion: Five preoperative tumor-related characteristics had an adverse effect on CRM involvement after TaTME. The predicted risk of positive CRM after TaTME for a specific patient can be calculated preoperatively with the proposed model and may help guide patient selection for optimal treatment and enhance a tailored treatment approach to further optimize oncological outcomes.
- Published
- 2019
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