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1. Thrombectomy in ischemic stroke patients with tandem occlusion in the posterior versus anterior circulation

Author

Cappellari, Manuel, Pracucci, Giovanni, Saia, Valentina, Mandruzzato, Nicolò, Valletta, Francesco, Sallustio, Fabrizio, Casetta, Ilaria, Fainardi, Enrico, Da Ros, Valerio, Diomedi, Marina, Capasso, Francesco, Nencini, Patrizia, Vallone, Stefano, Bigliardi, Guido, Tessitore, Agostino, La Spina, Paolino, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Ruggiero, Maria, Longoni, Marco, Castellan, Lucio, Malfatto, Laura, Saletti, Andrea, De Vito, Alessandro, Menozzi, Roberto, Scoditti, Umberto, Simonetti, Luigi, Zini, Andrea, Lafe, Elvis, Cavallini, Anna, Lazzarotti, Guido Andrea, Giannini, Nicola, Boghi, Andrea, Naldi, Andrea, Romano, Daniele, Napoletano, Rosa, Comai, Alessio, Franchini, Enrica, Cavasin, Nicola, Critelli, Adriana, Giorgianni, Andrea, Cariddi, Lucia Princiotta, Semeraro, Vittorio, Boero, Giovanni, Zimatore, Domenico Sergio, Petruzzellis, Marco, Biraschi, Francesco, Nicolini, Ettore, Pedicelli, Alessandro, Frisullo, Giovanni, Calzoni, Andrea, Tassinari, Tiziana, Gallesio, Ivan, Sepe, Federica, Filauri, Pietro, Sacco, Simona, Lozupone, Emilio, Rizzo, Annalisa, Besana, Michele, Giossi, Alessia, Pavia, Marco, Invernizzi, Paolo, Amistà, Pietro, Russo, Monia, Florio, Francesco, Inchingolo, Vincenzo, Filizzolo, Marco, Mannino, Marina, Mangiafico, Salvatore, and Toni, Danilo

Published
2024
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9. Association of the careggi collateral score with radiological outcomes after thrombectomy for stroke with an occlusion of the middle cerebral artery

Author

Cappellari, Manuel, Saia, Valentina, Pracucci, Giovanni, Fainardi, Enrico, Nencini, Patrizia, Malfatto, Laura, Tassi, Rossana, Cerrato, Paolo, Mancuso, Michelangelo, Pesare, Angela, La Spina, Paolino, Lotti, Enrico Maria, Casalena, Alfonsina, Petruzzellis, Marco, Baracchini, Claudio, Via, Alessandra Giai, Gaudiano, Carmen, Sallustio, Fabrizio, Tassinari, Tiziana, Critelli, Adriana, Melis, Maurizio, Persico, Alessandra, Casetta, Ilaria, Sacco, Simona, Ferrandi, Delfina, Marcheselli, Simona, Russo, Monia, Zivelonghi, Cecilia, Mandruzzato, Nicolò, Invernizzi, Paolo, Romano, Daniele, Nicolini, Ettore, Scoditti, Umberto, Magoni, Mauro, Cariddi, Lucia Princiotta, Vallone, Stefano, Inzitari, Domenico, Toni, Danilo, and Mangiafico, Salavatore

Published
2022
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10. Ischemic stroke and reperfusion therapies in diabetic patients

Author

Currò, Carmelo Tiberio, Fiume, Giulia, Cotroneo, Masina, Russo, Giuseppina, Casella, Carmela, Dell’Aera, Cristina, Fazio, Maria Carolina, Grillo, Francesco, Laganà, Angelina, Trimarchi, Giuseppe, Toscano, Antonio, Vinci, Sergio Lucio, Musolino, Rosa Fortunata, and La Spina, Paolino

Published
2022
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11. Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19.

Author

Scutelnic, Adrian, van de Munckhof, Anita, Miraclin, Angel T., Aaron, Sanjith, Hameed, Sajid, Wasay, Mohammad, Grosu, Oxana, Krzywicka, Katarzyna, Sánchez van Kammen, Mayte, Lindgren, Erik, Moreira, Tiago, Acampora, Roberto, Negro, Alberto, Karapanayiotides, Theodoros, Yaghi, Shadi, Revert, Anna, Cuadrado Godia, Elisa, Garcia-Madrona, Sebastian, La Spina, Paolino, and Grillo, Francesco

Published
2024
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12. Ischemic Stroke and Asymptomatic Pulmonary Opacities

Author

Currò, Carmelo Tiberio, Cotroneo, Masina, Ciacciarelli, Antonio, Dell'Aera, Cristina, Grillo, Francesco, La Spina, Paolino, Fazio, Maria Carolina, Laganà, Angelina, De Caro, Jolanda, Trimarchi, Giuseppe, Toscano, Antonio, Musolino, Rosa Fortunata, and Casella, Carmela

Published
2022
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13. Variants of the circle of Willis in ischemic stroke patients

Author

De Caro, Jolanda, Ciacciarelli, Antonio, Tessitore, Agostino, Buonomo, Orazio, Calzoni, Andrea, Francalanza, Isabella, Dell’Aera, Cristina, Cosenza, Domenico, Currò, Carmelo Tiberio, Granata, Francesca, Vinci, Sergio Lucio, Trimarchi, Giuseppe, Toscano, Antonio, Musolino, Rosa Fortunata, and La Spina, Paolino

Published
2021
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14. Foam Cells Analysis from Retrieved Stroke Clot for the Identification of Atherothrombotic Etiology.

Author

Giammello, Fabrizio, Ciacciarelli, Antonio, Cosenza, Domenico, Galletta, Santi, Barresi, Valeria, La Spina, Paolino, Fazio, Maria Carolina, De Caro, Jolanda, Cotroneo, Masina, Dell'Aera, Cristina, Grillo, Francesco, Ammendola, Serena, Tessitore, Agostino, Vinci, Sergio Lucio, Musolino, Rosa Fortunata, Casella, Carmela, and Toscano, Antonio

Subjects
FOAM cells, STROKE, ATHEROSCLEROTIC plaque, ETIOLOGY of diseases, HISTOPATHOLOGY
Abstract

Background: In atherothrombotic acute ischemic stroke (AIS), when the atheroma breaks down, the clot can incorporate foam cells (FCs). The identification of the correct etiology is paramount for secondary stroke prevention. This study aims to evaluate the presence of the FC in the arterial clot, and to determine whether patients with FCs and patients without FCs (NFCs) had different cerebrovascular risk factors, haemato-chemical parameters, and atherosclerotic disease incidence, in order to predict the etiological diagnosis. Methods: We collected 100 clots retrieved by mechanical thrombectomy from 495 consecutive AIS patients with large vessel occlusion. An expert pathologist evaluated the FC presence by histological examination stained with hematoxylin and eosin. Results: We observed FCs in 29/100 (29%) of retrieved clots and divided the patients into two groups, with/without FCs. The two groups had similar clinical and laboratory features, with a discrepancy between the FC presence in the clot and the clinical etiological diagnosis, even if not statistically significant. Conclusions: Our study showed the presence of FCs in approximately one-third of the retrieved clots, but the identification of the clot that presumably comes from the atheromatous plaque rupture tended to disagree with the clinical diagnosis. Future studies may reveal their potential to disclose clot origin or specific patient characteristics, guiding treatment options. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Non-conducted premature atrial complexes: A new independent predictor of atrial fibrillation in cryptogenic stroke

Author

Vetta, Giampaolo, primary, Parlavecchio, Antonio, additional, Caminiti, Rodolfo, additional, Crea, Pasquale, additional, Magnocavallo, Michele, additional, Della Rocca, Domenico Giovanni, additional, Lavalle, Carlo, additional, Vetta, Francesco, additional, Marano, Giovanni, additional, Ruggieri, Chiara, additional, Lofrumento, Francesca, additional, Dattilo, Giuseppe, additional, Ferraù, Ludovica, additional, Dell'Aera, Cristina, additional, Giammello, Fabrizio, additional, La Spina, Paolino, additional, Musolino, Rosa Fortunata, additional, Luzza, Francesco, additional, Carerj, Scipione, additional, Micari, Antonio, additional, and Di Bella, Gianluca, additional

Published
2022
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24. Minor stroke with bilateral acute infarctions and combined vascular anomalies: A complex case report

Author

Giammello, Fabrizio, primary, Dell’Aera, Cristina, additional, Grillo, Francesco, additional, Cotroneo, Masina, additional, Casella, Carmela, additional, La Spina, Paolino, additional, Currò, Carmelo T., additional, Velo, Mariano, additional, Granata, Francesca, additional, Toscano, Antonio, additional, Musolino, Rosa F., additional, and Fazio, Maria C., additional

Published
2020
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25. Recurrent intracranial hemorrhage and cerebral venous sinus thrombosis: an atypical case of Neuro-Behçet’s Syndrome

Author

Giammello, Fabrizio, primary, Dell’Aera, Cristina, additional, Grillo, Francesco, additional, Cotroneo, Masina, additional, Casella, Carmela, additional, Fazio, Maria Carolina, additional, La Spina, Paolino, additional, Francalanza, Isabella, additional, Fiorenza, Alessia, additional, Toscano, Antonio, additional, Atzeni, Fabiola, additional, and Musolino, Rosa Fortunata, additional

Published
2020
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26. Isolated Insular Stroke: Clinical Presentation

Author

Giammello, Fabrizio, primary, Cosenza, Domenico, additional, Casella, Carmela, additional, Granata, Francesca, additional, Dell’Aera, Cristina, additional, Fazio, Maria Carolina, additional, La Spina, Paolino, additional, Grillo, Francesco, additional, Cotroneo, Masina, additional, Toscano, Antonio, additional, and Musolino, Rosa Fortunata, additional

Published
2020
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28. IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke

Author

Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, De Michele, Manuela, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria Federica, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, Toni, Danilo, Limbucci, Nicola, Consoli, Arturo, Renieri, Leonardo, Fainardi, Enrico, Gandini, Roberto, Pampana, Enrico, Diomedi, Marina, Koch, Giacomo, Verganti, Luca, Sacchetti, Federico, Zelent, Gabriele, Bigliardi, Guido, Picchetto, Livio, Vandelli, Laura, Romano, Daniele Giuseppe, Cioni, Samuele, Gennari, Paola, Cerase, Alfonso, Martini, Giuseppe, Stura, Guido, Daniele, Dino, Naldi, Andrea, Papa, Rosario, Vinci, Sergio Lucio, Bernava, Gianmarco, Velo, Mariano, Caragliano, Antonio, Tessitore, Agostino, Buonomo, Orazio, Musolino, Rossella, La Spina, Paolino, Casella, Carmela, Carolina Fazio, Maria, Cotroneo, Masina, Onofrio, Marcello, Azzini, Cristiano, Casetta, Ilaria, Mardighian, Dikran, Frigerio, Michele, Costa, Angelo, Di Egidio, Vincenzo, Lattanzi, Ruggero, Assetta, Maurizio, Cester, Giacomo, Mavilio, Nicola, Serrati, Carlo, Piazza, Paolo, Epifani, Enrico, Andreone, Andrea, Castellini, Paola, Latte, Lilia, Grisendi, Ilaria, Vaudano, Giacomo, Comelli, Simone, Cavallo, Roberto, Chianale, Gigliola, Simonetti, Luigi, Taglialatela, Francesco, Isceri, Salvatore, Procaccianti, Gaetano, Zaniboni, Anna, Borghi, Annamaria, Bonatti, Giampietro, Ferro, Federica, Bonatti, Matteo, Dall’Ora, Elisa, Currò Dossi, Roberto, Turri, Emanuela, Turri, Mara, Puglioli, Michele, Lazzarotti, Guido, Lauretti, DARIO LUCA, Giannini, Nicola, Maccarone, Miriam, Orlandi, Giovanni, Chiti, Alberto, Guidetti, Giulio, Biraschi, Francesco, Falcou, Anne, Anzini, Alexia, Mancini, Alessandra, Fausti, Silvia, Di Mascio, Maria Teresa, Durastanti, Laura, Sbardella, Emilia, Mellina, Vittorio, Baruzzi, Fabio, Pellegrino, Carlo, Terrana, Alberto, Carimati, Federico, Ruggiero, Maria, Sanna, Antioco, Passarin, Maria Grazia, Colosimo, Cesare, Pedicelli, Alessandro, D’Argento, Francesco, Alexandre, Andrea, Frisullo, Giovanni, Zappoli, Federico, Martignoni, Alessandra, Cavallini, Anna, Persico, Alessandra, Valvassori, Luca, Piano, Mariangela, Agostoni, Elio, Motto, Cristina, Gatti, Antonella, Longoni, Marco, Guccione, Angelo, Tortorella, Rachele, Zampieri, Piergiuseppe, Zimatore, Domenico Sergio, Grazioli, Andrea, Ricciardi, Giuseppe Kenneth, Augelli, Raffaele, Bovi, Paolo, Tomelleri, Giampaolo, Micheletti, Nicola, Semeraro, Vittorio, Lucarelli, Nicola, Ganimede, Maria, Tinelli, Angelica, Pia Prontera, Maria, Pesare, Angela, Cagliari, Enrico, Quatrale, Rocco, Federico, Francesco, Passalacqua, Giovanni, Filauri, Pietro, Orlandi, Berardino, De Santis, Federica, Gabriele, Amleto, Tiseo, Cindy, Armentano, Antonio, Di Benedetto, Olindo, Silvagni, Umberto, Perrotta, Paolo, Crispino, Emanuela, Stancati, Furio, Rizzuto, Stefano, Pugliese, Pierfrancesco, Pisani, Ermanno, Siniscalchi, Antonio, Gaudiano, Carmen, Pirritano, Domenico, Del Giudice, Francesco, Calia, Stefano, Ganci, Giuseppe, Sugo, Annalisa, Scomazzoni, Francesco, Simionato, Franco, Roveri, Luisa, De Nicola, Maurizio, Giannoni, Mirko, Bruni, Stefano, Gambelli, Elena, Provinciali, Leandro, Carriero, Alessandro, Coppo, Lorenzo, Baldan, Julika, Paolo Nuzzi, Nunzio, Marcheselli, Simona, Corato, Manuel, Cotroneo, Enrico, Ricciardi, Fabrizio, Gigli, Renato, Pozzessere, Claudio, Pezzella, Francesca Romana, Corsi, Fabio, Squassina, Guido, Cobelli, Milena, Morassi, Mauro, Magni, Eugenio, Pepe, Fulvio, Bigni, Barbara, Costa, Paolo, Crabbio, Massimo, Griffini, Simona, Palmerini, Francesco, Piras, Maria Paola, Natrella, Massimiliano, Fanelli, Gianluca, Cristoferi, Massimo, Bottacchi, Edo, Corso, Giovanni, Tosi, Piera, Amistà, Pietro, Russo, Monia, Tettoni, Serena, Gallesio, Ivan, Mascolo, Maria Carmela, Meloni, Giovanni Battista, Fabio, Claudio, Maiore, Mario, Pintus, Francesco, Pischedda, Aldo, Manca, Antonio, Mongili, Claudia, Zanda, Bastianina, Sanna, Antonella, Baule, Antonio, Pappalardo, Maria Pia, Craparo, Giuseppe, Gallo, Cristina, Monaco, Serena, Mannino, Marina, Terruso, Valeria, Muto, Mario, Guarnieri, Gianluigi, Andreone, Vincenzo, Dui, Giovanni, Ticca, Anna, Salmaggi, Andrea, Iannucci, Giuseppe, Pinna, Vittore, Di Clemente, Loris, Perini, Francesco, De Boni, Antonella, De Luca, Cristina, De Giorgi, Franco, Corraine, Simona, Enne, Paolo, Ganau, Claudio, and Piras, Valeria

Subjects
Male, medicine.medical_specialty, Fibrinolytic Agents/therapeutic use Humans Male Middle Aged *Nomograms Postoperative Complications/etiology Risk Assessment Risk Factors Stroke/complications/drug therapy/*surgery Thrombectomy/*adverse effects Thrombolytic Therapy/adverse effects, medicine.medical_treatment, contraindications, Risk Assessment, NO, Brain Ischemia, Brain ischemia, Postoperative Complications, Fibrinolytic Agents, Risk Factors, contraindications ◼ logistic models ◼ nomograms ◼ standard of care ◼ thrombectomy, medicine, 80 and over, Humans, Thrombolytic Therapy, Stroke, contraindications, logistic models, nomograms, standard of care, thrombectomy, Aged, Cerebral Hemorrhage, Aged, 80 and over, Advanced and Specialized Nursing, Intracerebral hemorrhage, Receiver operating characteristic, business.industry, Thrombolysis, Nomogram, Middle Aged, medicine.disease, logistic models, nomograms, standard of care, thrombectomy, Female, Thrombectomy, Tissue Plasminogen Activator, Nomograms, Settore MED/26 - NEUROLOGIA, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Fibrinolytic agent, Cohort study
Abstract

Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed a nomogram for predicting symptomatic intracerebral hemorrhage in patients with large vessel occlusion in the anterior circulation who received bridging of thrombectomy with intravenous thrombolysis (training set), and to validate the model by using a cohort of patients treated with direct thrombectomy (test set). Methods— We conducted a cohort study on prospectively collected data from 3714 patients enrolled in the IER (Italian Registry of Endovascular Stroke Treatment in Acute Stroke). Symptomatic intracerebral hemorrhage was defined as any type of intracerebral hemorrhage with increase of ≥4 National Institutes of Health Stroke Scale score points from baseline ≤24 hours or death. Based on multivariate logistic models, the nomogram was generated. We assessed the discriminative performance by using the area under the receiver operating characteristic curve. Results— National Institutes of Health Stroke Scale score, onset-to-end procedure time, age, unsuccessful recanalization, and Careggi collateral score composed the IER-SICH nomogram. After removing Careggi collateral score from the first model, a second model including Alberta Stroke Program Early CT Score was developed. The area under the receiver operating characteristic curve of the IER-SICH nomogram was 0.778 in the training set (n=492) and 0.709 in the test set (n=399). The area under the receiver operating characteristic curve of the second model was 0.733 in the training set (n=988) and 0.685 in the test set (n=779). Conclusions— The IER-SICH nomogram is the first model developed and validated for predicting symptomatic intracerebral hemorrhage after thrombectomy. It may provide indications on early identification of patients for more or less postprocedural intensive management.

Published
2019

33. Acute Stroke Treatment in Patients with Basilar Artery Occlusion: A Single-Center Observational Study

Author

Francalanza, Isabella, primary, Ciacciarelli, Antonio, additional, Caragliano, Antonio Armando, additional, Casella, Carmela, additional, Cotroneo, Masina, additional, Dell’Aera, Cristina, additional, Fazio, Maria Carolina, additional, Grillo, Francesco, additional, Pitrone, Antonio, additional, Vinci, Sergio Lucio, additional, Trimarchi, Giuseppe, additional, Musolino, Rosa Fortunata, additional, and La Spina, Paolino, additional

Published
2019
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34. Stroke and Immune System: Therapeutic Targeting of Toll-Like Receptors

Author

Sofo, Vincenza, Soraci, Luca, Salmeri, Francesca Maria, Giulia, Soraci, LA SPINA, Paolino, and Gambuzza, MARIA ELSA

Subjects
Innate immunity, Stroke, DAMPs, Pro-inflammatory cytokines, TLR Agonists/Antagonists, DAMPs, IFN alpha/beta, Immunomodulators TLR-targeting, Inflammatory responses, Innate immunity, Ischemia/Reperfusion, Pro-inflammatory cytokines, Stroke, TLR Agonists/Antagonists, TLRs, IFN alpha/beta, Immunomodulators TLR-targeting, TLRs, Inflammatory responses, Ischemia/Reperfusion
Published
2017

35. Agenesis of the Internal Carotid Artery Associated with Generalized Epilepsy

Author

La Spina, Paolino, primary, Grillo, Francesco, additional, Granata, Francesca, additional, Casella, Carmela, additional, Fazio, Maria Carolina, additional, Colella, Margherita, additional, Cotroneo, Masina, additional, Dell'Aera, Cristina, additional, Ciacciarelli, Antonio, additional, Vita, Giuseppe, additional, and Musolino, Rosa, additional

Published
2018
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37. Prevalence of prothrombotic polymorphisms in a selected cohort of cryptogenic and noncryptogenic ischemic stroke patients

Author

Calabro, Rocco, La Spina, Paolino, Serra, Salvatore, Lagana, Angelina, Postorino, Paolo, Savica, Rodolfo, Mammi, Corrado, Lagana, Carmelo, and Musolino, Rosa

Subjects
Stroke (Disease) -- Risk factors -- Diagnosis -- Genetic aspects -- Research, Genetic polymorphisms -- Research -- Genetic aspects, Prothrombin -- Genetic aspects -- Research, Health, Diagnosis, Research, Genetic aspects, Risk factors
Abstract

Byline: Rocco. Calabro, Paolino. La Spina, Salvatore. Serra, Angelina. Lagana, Paolo. Postorino, Rodolfo. Savica, Corrado. Mammi, Carmelo. Lagana, Rosa. Musolino Ischemic stroke is a complex multifactorial disease and approximately 30%, [...]

Published
2009

38. Could cerebral ischemia save the life? Case report

Author

Fazio, M. C., LA SPINA, Paolino, Casella, Carmela, CUSMA' PICCIONE, Maurizio, Saporito, F., Trio, Olimpia, Autunno, Massimo, Raffaele, Massimo, Cotroneo, Masina, Dell'Aera, Cristina, Grillo, Francesco, Colella, Margherita, Stilo, CESARE AMERIGO, and Musolino, Rosa Fortunata

Published
2015

42. Stroke thrombectomy in the elderly: A propensity score matched study on a nationwide real-world registry.

Author

Romoli M, Migliaccio L, Saia V, Pracucci G, Cirillo L, Forlivesi S, Romano D, Casetta I, Fainardi E, Sallustio F, Limbucci N, Nencini P, Da Ros V, Diomedi M, Vallone S, Bigliardi G, Vinci SL, La Spina P, Bergui M, Cerrato P, Bracco S, Tassi R, Saletti A, Azzini C, Ruggiero M, Castellan L, Benzi Markushi T, Menozzi R, Pezzini A, Lazzarotti GA, Giannini N, Castellano D, Naldi A, Comai A, Dall'Ora E, Plebani M, Cappellari M, Frauenfelder G, Puglielli E, Casalena A, Burdi N, Boero G, Nappini S, Loizzo ND, Cavasin N, Critelli A, Ivaldi D, Tassinari T, Biraschi F, Nicolini E, Zimatore S, Petruzzellis M, Filauri P, Orlandi B, Gallesio I, Ferrandi D, Pavia M, Invernizzi P, Amistá P, Russo M, Paladini A, Rizzo A, Besana M, Giossi A, Filizzolo M, Mannino M, Mangiafico S, Toni D, and Zini A

Abstract

Introduction: Data on safety and efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke in older patients are limited and controversial, and people aged 80 or older were under-represented in randomized trials. Our aim was to assess EVT effect for ischemic stroke patients aged ⩾80 at a nationwide level., Patients and Methods: The cohort included stroke patients undergoing EVT from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS). Patients were a priori divided into younger and older groups (<80 vs ⩾80). Primary outcome was good functional outcome (modified Rankin scale, mRS, 0-2 at 90 days). Secondary outcomes were symptomatic intracranial hemorrhage (sICH), successful reperfusion, EVT abortion. Propensity score matching (PSM) was performed between age groups for baseline features, functional status, stroke severity and neuroradiological features. Logistic regression was implemented to test the weight of age group on the predefined outcomes., Results: Overall, 5872 individuals (1:1 matching, n  = 2936 aged ⩾80 vs n  = 2936 < 80) were matched from 13,922 records. In ⩾80 group 34.1% had good functional outcome, vs 51.2% in <80 group (absolute difference = -17.1%, p  < 0.001), with a 4.4% excess in EVT abortion. Age ⩾80 was a negative independent predictor of good functional outcome (aOR = 0.4, 95% CI = 0.3-0.5), but had no impact on sICH., Discussion and Conclusion: Age ⩾80 years represents a consistent predictor of worse functional outcome, independently from successful reperfusion and sICH. Cost-effectiveness studies are needed for tailored and implement sustainable care, and research should focus on strategies to improve functional outcome in older age patient groups., Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: MR declares support for educational activities from CLS-Behring and PRESTIGE-AF trial. SN declares consulting fees from Medtronic, Cerenovus, Stryker, and Balt. MC declares consultancy or advisory board fees or speaker’s honoraria from Pfizer/Bristol Meyer Squibb and Daiichi Sankyo. AZ received speaker and consultation fees from Alexion, CLS-Behring, Boehringer-Ingelheim. All the other authors report no disclosures.

Published
2024
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