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190 results on '"La Rocca, Francesco"'

3. Adopting the DSpace 7 platform: challenges, gaps, problematics, and solution formulas from real migration experiences

Author

Bollini, Andrea, Lombardi, Corrado, Cortese, Claudio, Barbasso, Andrea, Belletti, Fabio, Buso, Irene, Boychuk, Mykhaylo, Cosco, Alfredo, Digilio, Giuseppe, Fazio, Riccardo, Fiorenza, Damiano, Gandolini, Benedetta, Giamminonni, Luca, Golinelli, Elisa, Maffei, Stefano, Mecca, Vincenzo, Negretti, Davide, Orlandi, Sara, Pascarelli, Luigi Andrea, Perelli, Matteo, Pusiol, Adele, Scancarello, Immacolata, Scognamiglio, Francesco Pio, Tarli, Simone, La Rocca, Francesco, Verlicchi, Federico, Medina, Karla, and Mornati, Susanna

Subjects
OR2023
Abstract

This paper provides a detailed examination of the challenges, gaps, and problems that institutions may face in moving to the DSpace 7 platform from previous versions or from different and various platforms such as EPrints, Invenio, etc., and the implementation solutions already successfully rolled out in such instances. Through the use of live examples, the presentation aims to illustrate the complexities and nuances of migrating repositories to DSpace 7. 4Science has developed standard procedures that identify pitfalls and decision points and related best practices that will be shared with the audience to help define a better and more informed planning of this often critical phase. The transition and evolution to DSpace 7 represents a great opportunity to rethink the repository structure and provide new services to users. Even for institutions coming from previous versions, this evolution is much more than an upgrade; it is essentially a transition to a new platform. From this point of view, the challenges and opportunities go beyond the technical ones. By sharing the experience gained from dozens of migrations to DSpace 7, we hope to help other institutions facing this challenge to make the process as smooth and successful as possible.

Published
2023
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4. An update on DSpace CRIS, the state of the art tool for Research & Information management

Author

Bollini, Andrea, Lombardi, Corrado, Cortese, Claudio, Barbasso, Andrea, Belletti, Fabio, Buso, Irene, Boychuk, Mykhaylo, Cosco, Alfredo, Digilio, Giuseppe, Fazio, Riccardo, Fiorenza, Damiano, Gandolini, Benedetta, Giamminonni, Luca, Golinelli, Elisa, Maffei, Stefano, Negretti, Davide, Orlandi, Sara, Pascarelli, Luigi Andrea, Perelli, Matteo, Pusiol, Adele, Scancarello, Immacolata, Scognamiglio, Francesco Pio, Tarli, Simone, La Rocca, Francesco, Verlicchi, Federico, Mecca, Vincenzo, Medina, Karla, and Mornati, Susanna

Subjects
CRIS, Metrics, OR2023, DSpace, RIMS
Abstract

DSpace-CRIS is the first open source CRIS/RIMS platform in the world. It was born with the idea to put the repository at the core of the information ecosystem of Universities and with the ambition to bring utmost prestige and value to adopting institutions. Other approaches, usually promoted by communities less supportive to the open world, CRIS systems put the Repository to a side, subtracting resources, duplicating efforts and creating competing projects. Since its first release as open source, the Open Repository conference has represented a pivotal date in the year to look at the new achievements and future direction of the DSpace-CRIS project and its large user base of hundreds of installations around the world: this year,the DSpace-CRIS new developments since OR2022 and the updated project roadmap will be presented highlighting the relation with the parent DSpace project and the possible convergences.

Published
2023
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7. EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells

Author

La Rocca, Francesco, Airoldi, Irma, Di Carlo, Emma, Marotta, Pina, Falco, Geppino, Simeon, Vittorio, Laurenzana, Ilaria, Trino, Stefania, De Luca, Luciana, Todoerti, Katia, Villani, Oreste, Lackmann, Martin, D’Auria, Fiorella, Frassoni, Francesco, Neri, Antonino, Del Vecchio, Luigi, Musto, Pellegrino, Cilloni, Daniela, and Caivano, Antonella

Published
2017
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8. MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report

Author

Caivano, Antonella, La Rocca, Francesco, Simeon, Vittorio, Girasole, Marco, Dinarelli, Simone, Laurenzana, Ilaria, De Stradis, Angelo, De Luca, Luciana, Trino, Stefania, Traficante, Antonio, D’Arena, Giovanni, Mansueto, Giovanna, Villani, Oreste, Pietrantuono, Giuseppe, Laurenti, Luca, Del Vecchio, Luigi, and Musto, Pellegrino

Published
2017
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9. Epidemiology

Author

La Rocca, Francesco, Chianese, Francesco, Crovella, Feliciano, Crovella, Feliciano, Bartone, Giovanni, and Fei, Landino

Published
2008
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11. High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders

Author

Caivano, Antonella, Laurenzana, Ilaria, De Luca, Luciana, La Rocca, Francesco, Simeon, Vittorio, Trino, Stefania, D’Auria, Fiorella, Traficante, Antonio, Maietti, Maddalena, Izzo, Tiziana, D’Arena, Giovanni, Mansueto, Giovanna, Pietrantuono, Giuseppe, Laurenti, Luca, Musto, Pellegrino, and Del Vecchio, Luigi

Published
2015
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12. CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance

Author

D’Arena, Giovanni, primary, De Feo, Vincenzo, additional, Pietrantuono, Giuseppe, additional, Seneca, Elisa, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, La Rocca, Francesco, additional, D’Auria, Fiorella, additional, Statuto, Teodora, additional, Valvano, Luciana, additional, Arruga, Francesca, additional, Deaglio, Silvia, additional, Efremov, Dimitar G., additional, Sgambato, Alessandro, additional, and Laurenti, Luca, additional

Published
2020
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15. Superiority of Droplet Digital PCR Over Real-Time Quantitative PCR for JAK2 V617F Allele Mutational Burden Assessment in Myeloproliferative Neoplasms: A Retrospective Study

Author

La Rocca, Francesco, primary, Grieco, Vitina, additional, Ruggieri, Vitalba, additional, Zifarone, Emanuela, additional, Villani, Oreste, additional, Zoppoli, Pietro, additional, Russi, Sabino, additional, Laurino, Simona, additional, Falco, Geppino, additional, Calice, Giovanni, additional, Marinaccio, Anna, additional, Natalicchio, Maria Iole, additional, Albano, Francesco, additional, and Musto, Pellegrino, additional

Published
2020
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16. Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells

Author

Russi, Sabino, primary, Verma, Henu Kumar, additional, Laurino, Simona, additional, Mazzone, Pellegrino, additional, Storto, Giovanni, additional, Nardelli, Anna, additional, Zoppoli, Pietro, additional, Calice, Giovanni, additional, La Rocca, Francesco, additional, Sgambato, Alessandro, additional, Lucci, Valeria, additional, Falco, Geppino, additional, and Ruggieri, Vitalba, additional

Published
2019
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17. A novel member of Prame family, Gm12794c, counteracts retinoic acid differentiation through the methyltransferase activity of PRC2

Author

Napolitano, Giuliana, primary, Tagliaferri, Daniela, additional, Fusco, Salvatore, additional, Cirillo, Carmine, additional, De Martino, Ilaria, additional, Addeo, Martina, additional, Mazzone, Pellegrino, additional, Russo, Nicola Antonino, additional, Natale, Francesco, additional, Cardoso, Maria Cristina, additional, De Luca, Luciana, additional, Lamorte, Daniela, additional, La Rocca, Francesco, additional, De Felice, Mario, additional, and Falco, Geppino, additional

Published
2019
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18. TRPV2 Calcium Channel Gene Expression and Outcomes in Gastric Cancer Patients: A Clinically Relevant Association

Author

Zoppoli, Pietro, primary, Calice, Giovanni, additional, Laurino, Simona, additional, Ruggieri, Vitalba, additional, La Rocca, Francesco, additional, La Torre, Giuseppe, additional, Ciuffi, Mario, additional, Amendola, Elena, additional, De Vita, Ferdinando, additional, Petrillo, Angelica, additional, Napolitano, Giuliana, additional, Falco, Geppino, additional, and Russi, Sabino, additional

Published
2019
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21. CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance.

Author

D'Arena, Giovanni, De Feo, Vincenzo, Pietrantuono, Giuseppe, Seneca, Elisa, Mansueto, Giovanna, Villani, Oreste, La Rocca, Francesco, D'Auria, Fiorella, Statuto, Teodora, Valvano, Luciana, Arruga, Francesca, Deaglio, Silvia, Efremov, Dimitar G., Sgambato, Alessandro, and Laurenti, Luca

Subjects
CHRONIC lymphocytic leukemia, T cells, B cells, MANTLE cell lymphoma, IMMUNOREGULATION, CHRONIC leukemia
Abstract

CD200, a transmembrane type Ia glycoprotein belonging to the immunoglobulin protein superfamily, is broadly expressed on a wide variety of cell types, such as B lymphocytes, a subset of T lymphocytes, dendritic cells, endothelial and neuronal cells. It delivers immunosuppressive signals through its receptor CD200R, which is expressed on monocytes/myeloid cells and T lymphocytes. Moreover, interaction of CD200 with CD200R has also been reported to play a role in the regulation of tumor immunity. Overexpression of CD200 has been reported in chronic lymphocytic leukemia (CLL) and hairy cell leukemia but not in mantle cell lymphoma, thus helping to better discriminate between these different B cell malignancies with different prognosis. In this review, we focus on the role of CD200 expression in the differential diagnosis of mature B-cell neoplasms and on the prognostic significance of CD200 expression in CLL, where conflicting results have been published so far. Of interest, increasing evidences indicate that anti-CD200 treatment might be therapeutically beneficial for treating CD200-expressing malignancies, such as CLL. [ABSTRACT FROM AUTHOR]

Published
2020
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23. Oxidative stress in chronic lymphocytic leukemia: still a matter of debate

Author

D’Arena, Giovanni, primary, Seneca, Elisa, additional, Migliaccio, Ilaria, additional, De Feo, Vincenzo, additional, Giudice, Aldo, additional, La Rocca, Francesco, additional, Capunzo, Mario, additional, Calapai, Gioacchino, additional, Festa, Agostino, additional, Caraglia, Michele, additional, Musto, Pellegrino, additional, Iorio, Eugenio Luigi, additional, and Ruggieri, Vitalba, additional

Published
2018
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25. Prognostic relevance of oxidative stress measurement in chronic lymphocytic leukaemia

Author

D'Arena, Giovanni, primary, Vitale, Candida, additional, Perbellini, Omar, additional, Coscia, Marta, additional, La Rocca, Francesco, additional, Ruggieri, Vitalba, additional, Visco, Carlo, additional, Di Minno, Nicola Matteo Dario, additional, Innocenti, Idanna, additional, Pizza, Vincenzo, additional, Deaglio, Silvia, additional, Di Minno, Giovanni, additional, Giudice, Aldo, additional, Calapai, Gioacchino, additional, Musto, Pellegrino, additional, Laurenti, Luca, additional, and Iorio, Eugenio Luigi, additional

Published
2017
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27. Knockdown of miR-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia

Author

De Luca, Luciana, primary, Trino, Stefania, additional, Laurenzana, Ilaria, additional, Tagliaferri, Daniela, additional, Falco, Geppino, additional, Grieco, Vitina, additional, Bianchino, Gabriella, additional, Nozza, Filomena, additional, Campia, Valentina, additional, D'Alessio, Francesca, additional, La Rocca, Francesco, additional, Caivano, Antonella, additional, Villani, Oreste, additional, Cilloni, Daniela, additional, Musto, Pellegrino, additional, and Del Vecchio, Luigi, additional

Published
2017
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30. Characterization and Prognostic Relevance of Circulating Microvesicles in Chronic Lymphocytic Leukemia

Author

De Luca, Luciana, primary, D'Arena, Giovanni, additional, Simeon, Vittorio, additional, Trino, Stefania, additional, Laurenzana, Ilaria, additional, Caivano, Antonella, additional, La Rocca, Francesco, additional, Villani, Oreste, additional, Mansueto, Giovanna, additional, Deaglio, Silvia, additional, Innocenti, Idanna, additional, Laurenti, Luca, additional, Molica, Stefano, additional, Pietrantuono, Giuseppe, additional, De Stradis, Angelo, additional, Del Vecchio, Luigi, additional, and Musto, Pellegrino, additional

Published
2016
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31. A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies

Author

Laurenzana, Ilaria, primary, Caivano, Antonella, additional, La Rocca, Francesco, additional, Trino, Stefania, additional, De Luca, Luciana, additional, D’Alessio, Francesca, additional, Schenone, Silvia, additional, Falco, Geppino, additional, Botta, Maurizio, additional, Del Vecchio, Luigi, additional, and Musto, Pellegrino, additional

Published
2016
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32. MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report

Author

Caivano, Antonella, primary, La Rocca, Francesco, additional, Simeon, Vittorio, additional, Girasole, Marco, additional, Dinarelli, Simone, additional, Laurenzana, Ilaria, additional, De Stradis, Angelo, additional, De Luca, Luciana, additional, Trino, Stefania, additional, Traficante, Antonio, additional, D’Arena, Giovanni, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, Pietrantuono, Giuseppe, additional, Laurenti, Luca, additional, Del Vecchio, Luigi, additional, and Musto, Pellegrino, additional

Published
2016
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36. Oxidative stress in chronic lymphocytic leukemia: still a matter of debate.

Author

D'Arena, Giovanni, Seneca, Elisa, Migliaccio, Ilaria, De Feo, Vincenzo, Giudice, Aldo, La Rocca, Francesco, Capunzo, Mario, Calapai, Gioacchino, Festa, Agostino, Caraglia, Michele, Musto, Pellegrino, Iorio, Eugenio Luigi, and Ruggieri, Vitalba

Subjects
CHRONIC lymphocytic leukemia, OXIDATIVE stress, CARCINOGENESIS, REACTIVE oxygen species, DEBATE
Abstract

There is a large body of evidence showing a strong correlation between carcinogenesis of several types of human tumors, including chronic lymphocytic leukemia (CLL), and oxidative stress (OS). The mechanisms by which OS may promote cancer pathogenesis have not been completely deciphered yet and, in CLL, as in other neoplasms, whether OS is a primary cause or simply a downstream effect of the disease is still an open question. It has been demonstrated that, in CLL, OS concomitantly results from increased reactive oxygen species (ROS) production, mainly ascribable to CLL cells mitochondrial activity, and impaired antioxidant defenses. Interestingly, OS evaluation in CLL patients, at diagnosis, seems to have a prognostic significance, thus getting new insights in the biological comprehension of the disease with potential therapeutic implications. [ABSTRACT FROM AUTHOR]

Published
2019
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38. A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia

Author

Laurenzana, Ilaria, primary, Caivano, Antonella, additional, Trino, Stefania, additional, De Luca, Luciana, additional, La Rocca, Francesco, additional, Simeon, Vittorio, additional, Tintori, Cristina, additional, D’Alessio, Francesca, additional, Teramo, Antonella, additional, Zambello, Renato, additional, Traficante, Antonio, additional, Maietti, Maddalena, additional, Semenzato, Gianpietro, additional, Schenone, Silvia, additional, Botta, Maurizio, additional, Musto, Pellegrino, additional, and Del Vecchio, Luigi, additional

Published
2016
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39. MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: a new insight in transplantation

Author

De Luca, Luciana, primary, Trino, Stefania, additional, Laurenzana, Ilaria, additional, Simeon, Vittorio, additional, Calice, Giovanni, additional, Raimondo, Stefania, additional, Podestà, Marina, additional, Santodirocco, Michele, additional, Di Mauro, Lazzaro, additional, La Rocca, Francesco, additional, Caivano, Antonella, additional, Morano, Annalisa, additional, Frassoni, Francesco, additional, Cilloni, Daniela, additional, Del Vecchio, Luigi, additional, and Musto, Pellegrino, additional

Published
2015
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40. A Pyrazolo[3,4-d]Pyrimidine Compound Reduces Fyn Phosphorylation and Induces Apoptosis in Large Granular Lymphocyte Leukemia Cells

Author

Laurenzana, Ilaria, primary, Caivano, Antonella, additional, La Rocca, Francesco, additional, Trino, Stefania, additional, De Luca, Luciana, additional, D'Alessio, Francesca, additional, Tintori, Cristina, additional, Simeon, Vittorio, additional, Traficante, Antonio, additional, Teramo, Antonella, additional, Zambello, Renato, additional, Semenzato, Gianpietro, additional, Schenone, Silvia, additional, Botta, Maurizio, additional, Musto, Pellegrino, additional, and Del Vecchio, Luigi, additional

Published
2015
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41. Autoimmune Cytopenias in Chronic Lymphocytic Leukemia

Author

D'Arena, Giovanni, Guariglia, Roberto, La Rocca, Francesco, Trino, Stefania, Condelli, Valentina, De Martino, Laura, De Feo, Vincenzo, and Musto, Pellegrino

Subjects
Article Subject, hemic and lymphatic diseases
Abstract

The clinical course of chronic lymphocytic leukemia (CLL) may be complicated at any time by autoimmune phenomena.The most common ones are hematologic disorders, such as autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Pure red cell aplasia (PRCA) and autoimmune agranulocytosis (AG) are, indeed, more rarely seen. However, they are probably underestimated due to the possible misleading presence of cytopenias secondary to leukemic bone marrow involvement or to chemotherapy cytotoxicity. The source of autoantibodies is still uncertain, despite the most convincing data are in favor of the involvement of resting normal B-cells. In general, excluding the specific treatment of underlying CLL, the managementof these complications is not different from that of idiopathic autoimmune cytopenias or of those associated to other causes. Among different therapeutic approaches, monoclonal antibody rituximab, given alone or in combination, has shown to be very effective.

Published
2013
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43. Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine

Author

Simeon, Vittorio, primary, Todoerti, Katia, additional, La Rocca, Francesco, additional, Caivano, Antonella, additional, Trino, Stefania, additional, Lionetti, Marta, additional, Agnelli, Luca, additional, De Luca, Luciana, additional, Laurenzana, Ilaria, additional, Neri, Antonino, additional, and Musto, Pellegrino, additional

Published
2015
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44. Inverse regulation of bridging integrator 1 and BCR-ABL1 in chronic myeloid leukemia

Author

Trino, Stefania, primary, De Luca, Luciana, additional, Simeon, Vittorio, additional, Laurenzana, Ilaria, additional, Morano, Annalisa, additional, Caivano, Antonella, additional, La Rocca, Francesco, additional, Pietrantuono, Giuseppe, additional, Bianchino, Gabriella, additional, Grieco, Vitina, additional, Signorino, Elisabetta, additional, Fragasso, Alberto, additional, Bochicchio, Maria Teresa, additional, Venturi, Claudia, additional, Rosti, Gianantonio, additional, Martinelli, Giovanni, additional, Del Vecchio, Luigi, additional, Cilloni, Daniela, additional, and Musto, Pellegrino, additional

Published
2015
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48. Exposure of Cord Blood Hematopoietic Stem Cells to Bone Marrow Mesenchimal Cells-Derived Microvesicles Induces Cell Survival and Inhibition of Differentiation

Author

De Luca, Luciana, primary, Trino, Stefania, additional, Simeon, Vittorio, additional, Laurenzana, Ilaria, additional, Raimondo, Stefania, additional, Podestà, Marina, additional, Santodirocco, Michele, additional, Di Mauro, Lazzaro, additional, La Rocca, Francesco, additional, Caivano, Antonella, additional, Morano, Annalisa, additional, Del Vecchio, Luigi, additional, Frassoni, Francesco, additional, Cilloni, Daniela, additional, and Musto, Pellegrino, additional

Published
2014
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49. High Serum Levels of Extracellular Vesicles which Express Specific Markers of Malignancy Are Released in Patients with Various Types of Hematological Neoplastic Disorders

Author

Caivano, Antonella, primary, De Luca, Luciana, additional, Laurenzana, Ilaria, additional, La Rocca, Francesco, additional, Simeon, Vittorio, additional, Trino, Stefania, additional, Morano, Annalisa, additional, D'Auria, Fiorella, additional, Musto, Pellegrino, additional, and Del Vecchio, Luigi, additional

Published
2014
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50. Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia.

Author

De Luca, Luciana, D'Arena, Giovanni, Simeon, Vittorio, Trino, Stefania, Laurenzana, Ilaria, Caivano, Antonella, La Rocca, Francesco, Villani, Oreste, Mansueto, Giovanna, Deaglio, Silvia, Innocenti, Idanna, Laurenti, Luca, Molica, Stefano, Pietrantuono, Giuseppe, De Stradis, Angelo, Del Vecchio, Luigi, and Musto, Pellegrino

Subjects
LYMPHOCYTIC leukemia, MULTIVARIATE analysis, B cells, SERUM, LYMPHOCYTES, TUMORS, DIAGNOSIS
Abstract

Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition, CD19 + and CD37+, B-cell derived MV, significantly correlated with high tumor burden. Absolute MV number cutoff selected by ROC analysis distinguished Rai stage 0 patients with shorter time to treatment (TTT) from those with more stable disease. Likewise, in the entire cohort, two groups of patients with different overall survival (OS) and different TTT were identified. At multivariate analysis, serum MV independently predicted for OS (along with Rai stage) and TTT (along with Rai stage, lymphocytes and CD38). In conclusion, circulating MV represent a new potential prognostic biomarker in CLL. [ABSTRACT FROM PUBLISHER]

Published
2017
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