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1. Vitamin D in the development and progression of alzheimer’s disease: implications for clinical management

Author

Panza, F., La Montagna, M., Lampignano, L., Zupo, R., Bortone, I., Castellana, F., Sardone, R., Borraccino, L., Dibello, V., Resta, E., Altamura, M., Daniele, A. (ORCID:0000-0003-1641-5852), Lozupone, M., Panza, F., La Montagna, M., Lampignano, L., Zupo, R., Bortone, I., Castellana, F., Sardone, R., Borraccino, L., Dibello, V., Resta, E., Altamura, M., Daniele, A. (ORCID:0000-0003-1641-5852), and Lozupone, M.

Abstract

Introduction: Although the pathophysiological bases of Alzheimer’s disease (AD) remain incompletely understood and disease-modifying therapies are not available, intervention on modifiable risk factors is warranted. Research on nutrition and dietary components is challenging and controversies still persist about the role of micro- and macronutrients and health outcomes in dementia. Importantly, results of preclinical investigations have shown that vitamin D triggers different neural pathways that may be protective against these neurodegenerative mechanisms, including the deposition of amyloid plaques, inflammatory processes, neurofibrillary degeneration, glutamatergic excitotoxicity, excessive intraneuronal calcium influx, and oxidative stress, although its relationship with AD still needs to be fully understood. Areas covered: The authors analyzed the recent evidence about the effects of vitamin D insufficiency on AD and the role of supplementation. Expert opinion: Both insufficient (25–49.9 ng/ml) and deficient levels (<25 ng/ml) of vitamin D may contribute to an increased susceptibility to AD. However, further well-designed prospective studies are needed for a better understanding of the involvement of low vitamin D concentrations in the AD natural history. Randomized clinical trials will also be necessary to address the issue of causality and determine whether vitamin D supplementation may be effective for the prevention or treatment of AD.

Published
2021

3. Social Frailty in the COVID-19 Pandemic Era

Author

Lozupone, M., La Montagna, M., Di Gioia, I., Sardone, R., Resta, E., Daniele, Antonio, Giannelli, G., Bellomo, Alberto, Panza, F., Daniele A. (ORCID:0000-0003-1641-5852), Bellomo A., Lozupone, M., La Montagna, M., Di Gioia, I., Sardone, R., Resta, E., Daniele, Antonio, Giannelli, G., Bellomo, Alberto, Panza, F., Daniele A. (ORCID:0000-0003-1641-5852), and Bellomo A.

Abstract

Special attention and efforts to protect from or reduce health-related outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus triggering coronavirus disease 2019 (COVID-19), should be applied in susceptible populations, including frail older people. In particular, the early death cases occurred primarily in older people with a frailty status, possibly due to a weaker immune system fostering faster progression of the viral infection. Frailty is an age-related multidimensional clinical condition defined as a non-specific state of vulnerability, identifying older people at increased risk of falls, institutionalization, hospitalization, disability, dementia, and death. Among frailty phenotypes, social frailty has been least studied. It considers the role of socioeconomic context as a vulnerability status later in life. COVID-19 does not affect all populations equally, and social inequalities contribute to drive the spread of infections. It was known that the perception of social isolation, e.g., loneliness, affects mental and physical health, but the implicated molecular mechanisms, also related to the immune system, and its associated cognitive and health-related sequelae, are poorly understood. The increasing psychological distress derived by prolonged exposure to stress due to the lockdown scenario, and the reduced sources of support, contributed to making heavy demands on personal resources, i.e., self-efficacy and interpersonal variables. So, perceived loneliness may be a factor associated with psychological distress and an outcome in itself. In the COVID-19 pandemic era, a correct assessment of social frailty may be essential in terms of the prevention of late-life neuropsychiatric disorders.

Published
2020

4. Familial aggregation of MATRICS Consensus Cognitive Battery scores in a large sample o outpatients with schizophrenia and their unaffected relatives

Author

Mucci A., Galderisi S., Green M. F., Nuechterlein K., Rucci P., Gibertoni D., Rossi A., Rocca P., Bertolino A., Bucci P., Hellemann G., Spisto M., Palumbo D., Aguglia E., Amodeo G., Amore M., Bellomo A., Brugnoli R., Carpiniello B., Dell'osso L., Di Fabio F., Di Giannantonio M., Di Lorenzo G., Marchesi C., Monteleone P., Montemagni C., Oldani L., Romano R., Roncone R., Stratta P., Tenconi E., Vita A., Zeppegno P., Maj M., Piegari G., Vignapiano A., Caputo F., Plescia G., Montefusco V., Mancini M., Attrotto M. T., Paladini V., Atti A. R., Barlati S., Galluzzo A., Mussoni C., Pinna F., Sanna L., Primavera D., Signorelli M. S., Minutolo G., Cannavo D., Acciavatti T., Santacroce R., Corbo M., Altamura M., La Montagna M., Carnevale R., Pizziconi G., Rossi R., Santarelli V., Giusti L., Malavolta M., Salza A., Murri M. B., Calcagno P., Bugliani M., Serati M., Orsenigo G., Gramaglia C., Gattoni E., Cattaneo C., Campagnola N., Ferronato L., Piovan C., Tonna M., Bettini E., Ossola P., Gesi C., Landi P., Rutigliano G., Biondi M., Girardi P., Buzzanca A., Zocconali M., Comparelli A., Mancinelli I., Niolu C., Ribolsi M., Siracusano A., Corrivetti G., Bartoli L., Diasco F., Bolognesi S., Goracci A., Fagiolini A., Bellino S., Cardillo S., Bracale N., Mucci, A., Galderisi, S., Green, M. F., Nuechterlein, K., Rucci, P., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Bucci, P., Hellemann, G., Spisto, M., Palumbo, D., Aguglia, E., Amodeo, G., Amore, M., Bellomo, A., Brugnoli, R., Carpiniello, B., Dell'Osso, L., Di Fabio, F., Di Giannantonio, M., Di Lorenzo, G., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Romano, R., Roncone, R., Stratta, P., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Piegari, G., Vignapiano, A., Caputo, F., Plescia, G., Montefusco, V., Mancini, M., Attrotto, M. T., Paladini, V., Atti, A. R., Barlati, S., Galluzzo, A., Mussoni, C., Pinna, F., Sanna, L., Primavera, D., Signorelli, M. S., Minutolo, G., Cannavo, D., Acciavatti, T., Santacroce, R., Corbo, M., Altamura, M., La Montagna, M., Carnevale, R., Pizziconi, G., Rossi, R., Santarelli, V., Giusti, L., Malavolta, M., Salza, A., Murri, M. B., Calcagno, P., Bugliani, M., Serati, M., Orsenigo, G., Gramaglia, C., Gattoni, E., Cattaneo, C., Campagnola, N., Ferronato, L., Piovan, C., Tonna, M., Bettini, E., Ossola, P., Gesi, C., Landi, P., Rutigliano, G., Biondi, M., Girardi, P., Buzzanca, A., Zocconali, M., Comparelli, A., Mancinelli, I., Niolu, C., Ribolsi, M., Siracusano, A., Corrivetti, G., Bartoli, L., Diasco, F., Bolognesi, S., Goracci, A., Fagiolini, A., Bellino, S., Cardillo, S., Bracale, N., and di Giannantonio, M.

Subjects
Attention, MCCB Italian standardization, reasoning and problem solving, social cognition, verbal learning, working memory, Proband, Adult, Male, Consensus, Psychometrics, Context (language use), social cognition, Verbal learning, working memory, 03 medical and health sciences, Attention, MCCB Italian standardization, reasoning and problem solving, verbal learning, Aged, Cognition, Cognitive Dysfunction, Family, Female, Humans, Middle Aged, Outpatients, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, 0302 clinical medicine, Social cognition, medicine, Applied Psychology, Psychiatry and Mental Health, Family aggregation, medicine.disease, 030227 psychiatry, Settore MED/25, Psychology, MATRICS, Neurocognitive, 030217 neurology & neurosurgery, Clinical psychology
Abstract

BackgroundThe increased use of the MATRICS Consensus Cognitive Battery (MCCB) to investigate cognitive dysfunctions in schizophrenia fostered interest in its sensitivity in the context of family studies. As various measures of the same cognitive domains may have different power to distinguish between unaffected relatives of patients and controls, the relative sensitivity of MCCB tests for relative–control differences has to be established. We compared MCCB scores of 852 outpatients with schizophrenia (SCZ) with those of 342 unaffected relatives (REL) and a normative Italian sample of 774 healthy subjects (HCS). We examined familial aggregation of cognitive impairment by investigating within-family prediction of MCCB scores based on probands’ scores.MethodsMultivariate analysis of variance was used to analyze group differences in adjusted MCCB scores. Weighted least-squares analysis was used to investigate whether probands’ MCCB scores predicted REL neurocognitive performance.ResultsSCZ were significantly impaired on all MCCB domains. REL had intermediate scores between SCZ and HCS, showing a similar pattern of impairment, except for social cognition. Proband's scores significantly predicted REL MCCB scores on all domains except for visual learning.ConclusionsIn a large sample of stable patients with schizophrenia, living in the community, and in their unaffected relatives, MCCB demonstrated sensitivity to cognitive deficits in both groups. Our findings of significant within-family prediction of MCCB scores might reflect disease-related genetic or environmental factors.

Published
2018

5. Disorganization and cognitive impairment in schizophrenia: new insights from electrophysiological findings

Author

Vignapiano, A., Koenig, T., Mucci, A., Giordano, G. M., Amodio, A., Altamura, M., Bellomo, A., Brugnoli, R., Corrivetti, G., Di Lorenzo, G., Girardi, P., Monteleone, P., Niolu, C., Galderisi, S., Maj, M., Piegari, G., Merlotti, E., Plescia, G. M., Montefusco, V., Gallo, O., Romano, P., Carnevale, R., La Montagna, M., Ferrentino, F., Siracusano, A., Comparelli, A., Corigliano, V., Cascino, G., Del Buono, G., Vignapiano, A., Koenig, T., Mucci, A., Giordano, G. M., Amodio, A., Altamura, M., Bellomo, A., Brugnoli, R., Corrivetti, G., Di Lorenzo, G., Girardi, P., Monteleone, P., Niolu, C., Galderisi, S., and Maj, M.

Subjects
Adult, Male, medicine.medical_specialty, alpha rhythm, difficulty in abstract thinking, disorganization dimension, neurocognitive domains, spectral power, topographic analysis, Alpha (ethology), Audiology, Neuropsychological Tests, 050105 experimental psychology, Correlation, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Cognition, Physiology (medical), medicine, Humans, 0501 psychology and cognitive sciences, Cognitive Dysfunction, 610 Medicine & health, Association (psychology), Problem Solving, Positive and Negative Syndrome Scale, General Neuroscience, 05 social sciences, Brain, Electroencephalography, 500 Science, Middle Aged, medicine.disease, Brain Waves, Electrophysiology, Neuropsychology and Physiological Psychology, Settore MED/25, Schizophrenia, 570 Life sciences, biology, Neurocognitive domain, Female, Schizophrenic Psychology, Psychology, Neurocognitive, 030217 neurology & neurosurgery
Abstract

In subjects with schizophrenia (SCZ), the disorganization dimension is a strong predictor of real-life functioning. "Conceptual disorganization" (P2), "Difficulty in abstract thinking" (N5) and "Poor attention" (G11) are core features of the disorganization factor, evaluated using the Positive and Negative Syndrome Scale. The heterogeneity of this dimension and its overlap with neurocognitive deficits are still debated. Within the multicenter study of the Italian Network for Research on Psychoses, we investigated electrophysiological and neurocognitive correlates of disorganization and its component items to assess the heterogeneity of this dimension and its possible overlap with neurocognitive deficits. Resting state EEG was recorded in 145 stabilized SCZ and 69 matched healthy controls (HC). Spectral amplitude was averaged in ten frequency bands. Neurocognitive domains were assessed by MATRICS Consensus Cognitive Battery (MCCB). RAndomization Graphical User software explored band spectral amplitude differences between groups and correlations with disorganization and MCCB scores in SCZ. Correlations between disorganization and MCCB scores were also investigated. Compared to HC, SCZ showed increased delta, theta, and beta 1 and decreased alpha 2 activity. A negative correlation between alpha 1 and disorganization was observed in SCZ. At the item level, only "N5" showed the same correlation. MCCB neurocognitive composite score was associated with disorganization, "P2" and "N5". Our findings suggest only a partial overlap between disorganization and neurocognitive impairment. The association of alpha 1 with the "N5" item suggests that some aspects of disorganization could be underpinned by the impairment of basic neurobiological functions that are only partially evaluated using MCCB.

Published
2019

15. Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life

Author

Panza, F., Lozupone, M., Sardone, R., Battista, P., Piccininni, M., Dibello, V., La Montagna, M., Stallone, R., Venezia, P., Liguori, A., Giannelli, G., Bellomo, A., Greco, A., Daniele, A., Seripa, D., Quaranta, N., Logroscino, G., Liguori A., Bellomo A., Greco A., Daniele A. (ORCID:0000-0003-1641-5852), Panza, F., Lozupone, M., Sardone, R., Battista, P., Piccininni, M., Dibello, V., La Montagna, M., Stallone, R., Venezia, P., Liguori, A., Giannelli, G., Bellomo, A., Greco, A., Daniele, A., Seripa, D., Quaranta, N., Logroscino, G., Liguori A., Bellomo A., Greco A., and Daniele A. (ORCID:0000-0003-1641-5852)

Abstract

The peripheral hearing alterations and central auditory processing disorder (CAPD) associated with age-related hearing loss (ARHL), may impact cognitive disorders in older age. In older age, ARHL is also a significant marker for frailty, another age-related multidimensional clinical condition with a nonspecific state of vulnerability, reduced multisystem physiological reserve, and decreased resistance to different stressors (i.e. sensorial impairments, psychosocial stress, diseases, injuries). The multidimensional nature of frailty required an approach based on different pathogeneses because this clinical condition may include sensorial, physical, social, nutritional, cognitive, and psychological phenotypes. In the present narrative review, the cumulative epidemiological evidence coming from several longitudinal population-based studies, suggested convincing links between peripheral ARHL and incident cognitive decline and dementia. Moreover, a few longitudinal case-control and population-based studies also suggested that age-related CAPD in ARHL, may be central in determining an increased risk of incident cognitive decline, dementia, and Alzheimer’s disease (AD). Cumulative meta-analytic evidence confirmed cross-sectional and longitudinal association of both peripheral ARHL and age-related CAPD with different domains of cognitive functions, mild cognitive impairment, and dementia, while the association with dementia subtypes such as AD and vascular dementia remained unclear. However, ARHL may represent a modifiable condition and a possible target for secondary prevention of cognitive impairment in older age, social isolation, late-life depression, and frailty. Further research is required to determine whether broader hearing rehabilitative interventions including coordinated counseling and environmental accommodations could delay or halt cognitive and global decline in the oldest old with both ARHL and dementia.

Published
2018

16. Adolescence: psychopathological discomfort, distress or psychiatric disorder? Clinical experience, description and analysis of a sample

Author

Bove Rm, Stefano Caccavale, Carmela Bravaccio, La Montagna M, Domenico Bove, Bove, D, Bove, R. M, Caccavale, S, Bravaccio, Carmela, La Montagna, M., Bove, Rm, Bravaccio, C, and La Montagna, M

Subjects
Male, medicine.medical_specialty, Adolescent, media_common.quotation_subject, Anxiety, medicine, Humans, Psychiatry, Child, media_common, Subclinical infection, Social functioning, business.industry, Mental Disorders, Mental illness, medicine.disease, Clinical Practice, Distress, Feeling, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, business, Stress, Psychological, Psychopathology
Abstract

The aim of this review is to highlight how many psychopathological disorders during adolescence are not easily detectable and interpretable. We investigated the related social, emotional and demographic factors linked to psychopathological distress, measuring the overall functioning of the child / adolescent and the consequent impact on academic and social functioning, and the implications that this entails on the emergence of feelings of discomfort and anxiety, major events adolescent anguish. Many psychopathological disorders are easily detectable and diagnosable in this particular stage of life, but they have the basics in adolescent distress, and they can they can generate a real psychiatric disorder. Thanks to the data emerging from clinical practice, it is necessary signal the need for a global view of the preadolescents and adolescents' operation, thus we can identify possible subclinical symptoms for onset of mental illness, so implement therapeutic strategies as more targeted and less invasive.

Published
2014

26. Bipolar Disorder, Obesity and Cognitive Impairment

Author

La Montagna, M., primary, Stella, E., additional, Ricci, F., additional, Borraccino, L., additional, Triggiani, A.I., additional, Panza, F., additional, Seripa, D., additional, Miscio, G., additional, Bellomo, A., additional, and Lozupone, M., additional

Published
2017
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27. The pharmacogenetic road to avoid adverse drug reactions and therapeutic failures in revolving door patients with psychiatric illnesses: focus on the CYP2D6 isoenzymes

Author

Panza, F, Lozupone, M, Stella, E, Miscio, G, La Montagna, M, Daniele, Antonio, di Mauro, L, Bellomo, A, Logroscino, Giandomenico, Greco, A, Seripa, D, Daniele, A (ORCID:0000-0003-1641-5852), Logroscino, G (ORCID:0000-0003-1301-5343), Panza, F, Lozupone, M, Stella, E, Miscio, G, La Montagna, M, Daniele, Antonio, di Mauro, L, Bellomo, A, Logroscino, Giandomenico, Greco, A, Seripa, D, Daniele, A (ORCID:0000-0003-1641-5852), and Logroscino, G (ORCID:0000-0003-1301-5343)

Abstract

Introduction: A periodical hospital readmission caused by therapeutic failures (TFs) and a worsening of clinical symptoms most often linked to adverse drug reactions (ADRs) are probably the major causes for the so-called revolving door condition in psychiatric illnesses. This review underlined the importance that pharmacogenetic data on cytochrome P450 (CYP), particularly CYP2D6 polymorphisms, may offer for the finger printing of the pharmacological treatment of psychiatric illnesses, given the relevance of this enzyme in metabolizing psychotropic drugs.Areas covered: We searched in the medical literature until July 2016 to review the role of functional variants in the CYP2D6 gene on observed ADRs and TFs in revolving door psychiatric patients.Expert commentary: CYP2D6 gene variants could in part explain the revolving door condition in patients attending a psychiatric setting. The preemptive known CYP genotypes associated to a reduced metabolizer status may help clinical decision-making to avoid concomitant treatments, increasing drug safety, so reducing therapeutic attempts, hospital admission, and the overall costs for the national health services. However, CYP2D6 gene is only a part of a complex mechanism in which genetic and non-genetic factors may take part. A possible role of the intrinsic variability of pharmacodynamics and imponderable environmental factors influencing the revolving door condition cannot be excluded.

Published
2016

30. Different Attitudes Toward Psychiatry and Psychiatric Patients in Nursing Students: Can Personal Experiences Reduce Stigma?

Author

Pascucci, M., primary, Rubini, G., additional, Stella, E., additional, La Montagna, M., additional, Capobianco, F., additional, Ventriglio, A., additional, De Angelis, A., additional, Parente, P., additional, Janiri, L., additional, Pozzi, G., additional, Di Nunzio, V., additional, Piemontese, G., additional, and Bellomo, A., additional

Published
2016
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39. Inverse notalgia paresthetica: a strange case of professional disease

Author

Tobia Caccavale, Stefano Caccavale, Massimo Mascolo, Maddalena La Montagna, Alessio Gambardella, Ada Lo Schiavo, Francesca Peccerillo, Schiavo, A. L., Peccerillo, F., Mascolo, M., La Montagna, M., Caccavale, T., Gambardella, A., Caccavale, S., Lo Schiavo, A, Peccerillo, F, Mascolo, M, La Montagna, M, Caccavale, T, Gambardella, A, and Caccavale, S

Subjects
Male, medicine.medical_specialty, business.industry, Hypertrophy, Dermatology, Disease, Middle Aged, medicine.disease, Occupational Disease, Pruritu, Hyperpigmentation, Peripheral Nerve, Paint, Physical therapy, medicine, Notalgia paresthetica, Paresthesia, Thoracic Wall, business, Cumulative Trauma Disorder, Human, Skin
Published
2014
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40. When basal cell carcinomas became giant: an Italian multicenter study

Author

Vito Simonetti, Paolo Amerio, Francesca Specchio, Stefano Caccavale, Marco Simonacci, Giuseppe Argenziano, Piergiacomo Calzavara-Pinton, Giulio Gualdi, Roberto Cecchi, Christian Landi, Fabrizio Fantini, Carlo Bornacina, Maddalena La Montagna, Mario Puviani, Maria A. G. Inchaurraga, Simone Caravello, Daniele Dusi, Pierfrancesco Zampieri, Paola Monari, Alfredo Zucchi, Alessandra Capo, Francesco Savoia, Davide Melandri, Gualdi, G., Monari, P., Calzavara-Pinton, P., Caravello, S., Fantini, F., Bornacina, C., Specchio, F., Argenziano, G., Simonetti, V., Caccavale, S., La Montagna, M., Cecchi, R., Landi, C., Simonacci, M., Dusi, D., Puviani, M., Zucchi, A., Zampieri, P., Inchaurraga, M. A. G., Savoia, F., Melandri, D., Capo, A., and Amerio, P.

Subjects
Male, medicine.medical_specialty, Average duration, Skin Neoplasms, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Basal cell, Basal cell carcinoma, Aged, Neoplasm Staging, Medical attention, Aged, 80 and over, business.industry, Middle Aged, medicine.disease, Multicenter study, Carcinoma, Basal Cell, 030220 oncology & carcinogenesis, Female, Previously treated, business, Case series
Abstract

Background: Giant basal cell carcinoma (GBCC) is a basal cell carcinoma (BCC) enlarged in a diameter more than 5cm. Since GBCCs are a highly infrequent entity and the occurrence rate is approximately 0.5–1% out of all BCC types, only anecdotal cases are reported, and causes and characteristics inducing development of this tumor are not defined. Objectives: Evaluate causative factors and clinico-histological characteristics of GBCCs. Methods: The study is a 6-month, hospital-based case series study performed in 12 Italian dermatologic centers. Results: A total of 59 cases and 458 control BCCs were collected. No significant differences existed between the two groups if we take into account social or cultural factors. The average duration of GBCCs is considerably longer than controls. GBCCs are located on unexposed areas while BCCs are on areas not usually covered by clothes. Superficial histological subtype was more frequent in the BCCs group, while infiltrative in GBCCs. GBCCs showed significantly higher local invasiveness, and greater metastatic capacity. More than half of GBCCs had been previously treated with one or more treatments. Conclusions: Patients with GBCCs appear to belong to two categories: (i) those who present with GBCC due to delay in accessing medical attention, and (ii) those who have BCCs previously treated with inappropriate strategies. Only very few cases can be carried out with intrinsic biological features of tumor aggressiveness. Social and cultural conditions do not appear to be involved in the development of GBCCS. These observations may help clinicians in selecting correct therapeutic strategies in the treatment of BCCs, which give rise to GBCC.

Published
2019
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41. Interplay Among Psychopathologic Variables, Personal Resources, Context-Related Factors, and Real-life Functioning in Individuals With Schizophrenia: A Network Analysis

Author

Galderisi, Silvana, Rucci, Paola, Kirkpatrick, Brian, Mucci, Armida, Gibertoni, Dino, Della Rocca, Paola, Rossi, Alessandro, Bertolino, Alessandro, Strauss, Gregory P., Aguglia, Eugenio, Bellomo, Antonello, Murri, Martino Belvederi, Bucci, Paola, Carpiniello, Bernardo, Comparelli, Anna, Cuomo, Alessandro, De Berardis, Domenico, Dell'Osso, Liliana, Di Fabio, Fabio, Gelao, Barbara, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Orsenigo, Giulia, Pacitti, Francesca, Roncone, Rita, Santonastaso, Paolo, Siracusano, Alberto, Vignapiano, Annarita, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Italian Network for Research on Psychoses, Aiello, Carmen, Molle, Debora, Nicita, Alessia, Patriarca, Sara, Pietrafesa, Daria, Longo, Luisa, Falsetti, Andrea, Barone, Marina, Galluzzo, Alessandro, Barlati, Stefano, Deste, Giacomo, Pinna, Federica, Primavera, Diego, Sanna, Lucia, Signorelli, Maria, Minutolo, Giuseppe, Cannavò, Dario, Corbo, Mariangela, Baroni, Gaia, Montemitro, Chiara, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Amore, Mario, Calcagno, Pietro, Bugliani, Michele, Parnanzone, Serena, Rossi, Rodolfo, Serrone, Dario, Giusti, Laura, Malavolta, Maurizio, Salza, Anna, Caldiroli, Alice, Mandolini, Gianmario, De Carlo, Vera, de Bartolomeis, Andrea, Gramaglia, Carla, Marangon, Debora, Prosperini, Pierluigi, Pierluigi, Elena, Meneguzzo, Paolo, Giannunzio, Valeria, Tonna, Matteo, Ossola, Paolo, Lidia Gerra, Maria, Gesi, Camilla, Mirko Cremone, Ivan, Carpita, Barbara, Brugnoli, Roberto, Del Casale, Antonio, Corigliano, Valentina, Biondi, Massimo, Zocconali, Monica, Buzzanca, Antonino, Corrivetti, Giulio, Pinto, Gaetano, Diasco, Ferdinando, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Niolu, Cinzia, Di Lorenzo, Giorgio, Ribolsi, Michele, Mancini, Irene, Brasso, Claudio, Bozzatello, Paola, Galderisi, Silvana, Rucci, Paola, Kirkpatrick, Brian, Mucci, Armida, Gibertoni, Dino, Rocca, Paola, Rossi, Alessandro, Bertolino, Alessandro, Strauss, Gregory P., Aguglia, Eugenio, Bellomo, Antonello, Murri, Martino Belvederi, Bucci, Paola, Carpiniello, Bernardo, Comparelli, Anna, Cuomo, Alessandro, De Berardis, Domenico, Dell'Osso, Liliana, Di Fabio, Fabio, Gelao, Barbara, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Orsenigo, Giulia, Pacitti, Francesca, Roncone, Rita, Santonastaso, Paolo, Siracusano, Alberto, Vignapiano, Annarita, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Aiello, C., Molle, D., Nicita, A., Patriarca, Paola, Pietrafesa, D., Longo, L., Falsetti, A., Barone, M., Galluzzo, A., Barlati, S., Deste, G., Pinna, F., Primavera, D., Sanna, L., Signorelli, M., Minutolo, G., Cannavò, D., Corbo, M., Baroni, G., Montemitro, C., Altamura, M., La Montagna, M., Carnevale, R., Amore, M., Calcagno, P., Bugliani, M., Parnanzone, S., Rossi, R., Serrone, D., Giusti, L., Malavolta, M., Salza, A., Caldiroli, A., Mandolini, G., De Carlo, V., de Bartolomeis, A., Gramaglia, C., Marangon, D., Prosperini, P., Pierluigi, E., Meneguzzo, P., Giannunzio, V., Tonna, M., Ossola, P., Gerra, M. L., Gesi, C., Cremone, I. M., Carpita, B., Brugnoli, R., Del Casale, A., Corigliano, V., Biondi, M., Zocconali, M., Buzzanca, A., Corrivetti, G., Pinto, G., Diasco, F., Fagiolini, A., Goracci, A., Bolognesi, S., Niolu, C., Di Lorenzo, G., Ribolsi, M., Mancini, I., Brasso, C., Bozzatello, P., Strauss, Gregory P, Galderisi, S., Rucci, P., Kirkpatrick, B., Mucci, A., Gibertoni, D., Rocca, P., Rossi, A., Bertolino, A., Strauss, G. P., Aguglia, E., Bellomo, A., Murri, M. B., Bucci, P., Carpiniello, B., Comparelli, A., Cuomo, A., De Berardis, D., Dell'Osso, L., Di Fabio, F., Gelao, B., Marchesi, C., Monteleone, P., Montemagni, C., Orsenigo, G., Pacitti, F., Roncone, R., Santonastaso, P., Siracusano, A., Vignapiano, A., Vita, A., Zeppegno, P., Maj, M., Patriarca, S., and Cannavo, D.

Subjects
Hospitals, Psychiatric, Male, Network Meta-Analysis, Social Environment, Hospitals, University, 0302 clinical medicine, Activities of Daily Living, Everyday life, Correlation of Data, Original Investigation, Psychopathology, Cognition, Middle Aged, Network Meta-Analysi, Hospitals, Psychiatry and Mental Health, Psychiatric Department, Social competence, Female, Schizophrenic Psychology, medicine.symptom, Psychology, Psychosocial, Social Adjustment, Clinical psychology, Human, Antipsychotic Agents, Adult, Psychiatric Department, Hospital, NO, 03 medical and health sciences, Hospital, Social cognition, medicine, Humans, Settore MED/25 - Psichiatria, Avolition, Cross-Sectional Studie, University, Mental health, Cross-Sectional Studies, Schizophrenia, Socioeconomic Factors, 030227 psychiatry, Antipsychotic Agent, Question How are real-life functioning, psychopathologic variables, cognition, personal resources, and sociodemographic variables connected to each other in community-dwelling individuals with schizophrenia? Findings In this network analysis of 740 individuals with schizophrenia, functional capacity and everyday life skills were the most central and interconnected nodes, while positive symptoms were the least interconnected nodes. Real-life functioning was connected with several variables belonging to different domains. Meaning The high centrality of functional capacity and everyday life skills suggests that improving the ability to perform tasks relevant to everyday life is critical for any therapeutic intervention in schizophrenia, and the pattern of network node connections supports the implementation of personalized interventions for individuals with schizophrenia, Psychiatric, Work Skills, 030217 neurology & neurosurgery
Abstract

Importance Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people with schizophrenia. To date, this is the first study using network analysis to investigate the associations among cognitive, psychopathologic, and psychosocial variables in a large sample of community-dwelling individuals with schizophrenia. Objective To assess the interplay among psychopathologic variables, cognitive dysfunctions, functional capacity, personal resources, perceived stigma, and real-life functioning in individuals with schizophrenia, using a data-driven approach. Design, Setting, and Participants This multicenter, cross-sectional study involved 26 university psychiatric clinics and/or mental health departments. A total of 921 community-dwelling individuals with a DSM-IV diagnosis of schizophrenia who were stabilized on antipsychotic treatment were recruited from those consecutively presenting to the outpatient units of the sites between March 1, 2012, and September 30, 2013. Statistical analysis was conducted between July 1 and September 30, 2017. Main Outcomes and Measures Measures covered psychopathologic variables, neurocognition, social cognition, functional capacity, real-life functioning, resilience, perceived stigma, incentives, and service engagement. Results Of 740 patients (221 women and 519 men; mean [SD] age, 40.0 [10.9] years) with complete data on the 27 study measures, 163 (22.0%) were remitted (with a score of mild or better on 8 core symptoms). The network analysis showed that functional capacity and everyday life skills were the most central and highly interconnected nodes in the network. Psychopathologic variables split in 2 domains, with positive symptoms being one of the most peripheral and least connected nodes. Functional capacity bridged cognition with everyday life skills; the everyday life skills node was connected to disorganization and expressive deficits. Interpersonal relationships and work skills were connected to avolition; the interpersonal relationships node was also linked to social competence, and the work skills node was linked to social incentives and engagement with mental health services. A case-dropping bootstrap procedure showed centrality indices correlations of 0.75 or greater between the original and randomly defined samples up to 481 of 740 case-dropping (65.0%). No difference in the network structure was found between men and women. Conclusions and Relevance The high centrality of functional capacity and everyday life skills in the network suggests that improving the ability to perform tasks relevant to everyday life is critical for any therapeutic intervention in schizophrenia. The pattern of network node connections supports the implementation of personalized interventions.

Published
2018

42. Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

Author

Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, M., Cuomo, A., Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., Vita, A., Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Bucci P., Galderisi S., Mucci A., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Andriola I., Bellomo A., Biondi M., Cuomo A., dell'Osso L., Favaro A., Gambi F., Giordano G.M., Girardi P., Marchesi C., Monteleone P., Montemagni C., Niolu C., Oldani L., Pacitti F., Pinna F., Roncone R., Vita A., Zeppegno P., Maj M., Patriarca S., Pietrafesa D., Aiello C., Longo L., Barone M., Romano R., Atti A.R., Barlati S., Deste G., Valsecchi P., Carpiniello B., Tusconi M., Puddu L., Signorelli M.S., Cannavo D., Minutolo G., Corbo M., Montemitro C., Baroni G., Altamura M., La Montagna M., Carnevale R., Murri M.B., Calcagno P., Bugliani M., Pizziconi G., Logozzo F., Rossi R., Giusti L., Salza A., Malavolta M., Orsenigo G., Grassi S., De Bartolomeis A., Gramaglia C., Gattoni E., Gambaro E., Tenconi E., Ferronato L., Collantoni E., Tonna M., Ossola P., Gerra M.L., Carmassi C., Cremone I.M., Carpita B., Buzzanca A., Girardi N., Frascarelli M., Del Casale A., Comparelli A., Corigliano V., Siracusano A., Di Lorenzo G., Ribolsi M., Corrivetti G., Bartoli L., Del Buono G., Fagiolini A., Bolognesi S., Goracci A., Mancini I., Bava I., Cardillo S., Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, Maria, Cuomo, Anna, Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., DE VITA, Anna, Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Biondi, M., Cuomo, A., Vita, A., and Casale, Antonio

Subjects
Male, avolition, Severity of Illness Index, cognitive functioning, 0302 clinical medicine, Cognition, Academic Performance, Medicine, Psychopathology, Depression, primary negative symptoms, Middle Aged, Psychiatric Status Rating Scale, avolition, cognitive functioning, poor emotion expression, premorbid adjustment, primary negative symptoms, poor emotion expression, premorbid adjustment, Psychiatry and Mental Health, Memory, Short-Term, Schizophrenia, Female, Schizophrenic Psychology, medicine.symptom, Psychosocial, Social Adjustment, Clinical psychology, Human, Adult, primary negative symptom, 03 medical and health sciences, Cognition Disorder, Memory, Social cognition, Humans, Cognitive Dysfunction, Cognitive skill, Social Behavior, Aged, Cognition Disorders, Motivation, Psychiatric Status Rating Scales, Settore MED/25 - Psichiatria, Avolition, business.industry, medicine.disease, 030227 psychiatry, Short-Term, business, Neurocognitive, 030217 neurology & neurosurgery
Abstract

Objective The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.

Published
2018

43. Hidradenitis suppurativa associated with squamous cell carcinoma: an example of an isoscartopic response

Author

Maddalena La Montagna, Stefano Caccavale, Tobia Caccavale, Caccavale, S, Caccavale, T, and La Montagna, M

Subjects
medicine.medical_specialty, Skin Neoplasms, business.industry, MEDLINE, Dermatology, medicine.disease, Hidradenitis Suppurativa, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Carcinoma, Humans, Medicine, Basal cell, Hidradenitis suppurativa, business
Published
2016
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44. Herpes compuctorum: a cutaneous infection related to permanent tattoo

Author

Maddalena La Montagna, Tobia Caccavale, Stefano Caccavale, Caccavale, S, Caccavale, T, and La Montagna, M

Subjects
medicine.medical_specialty, business.industry, MEDLINE, Follow up studies, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Text mining, 030220 oncology & carcinogenesis, Severity of illness, Medicine, Infectious etiology, business, Risk assessment
Published
2017

45. Facial flat warts in a young patient with a previous trauma: an example of isotraumatopic response

Author

Tobia Caccavale, Stefano Caccavale, Maddalena La Montagna, Caccavale, S, Caccavale, T, and La Montagna, M

Subjects
medicine.medical_specialty, business.industry, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Face, Facial Dermatosis, Medicine, Humans, Warts, business, Facial Dermatoses
Published
2016

46. Evaluation of skin disorders of lower limb amputation sites: is there a common denominator?

Author

Tobia Caccavale, Maddalena La Montagna, Stefano Caccavale, Caccavale, S, Caccavale, T, and La Montagna, M

Subjects
medicine.medical_specialty, business.industry, Amputation Stumps, Common denominator, Dermatology, Skin Diseases, Amputation, Surgical, Surgery, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Lower Extremity, Lower limb amputation, 030220 oncology & carcinogenesis, Humans, Medicine, business
Published
2017
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47. A case of morphea following radiotherapy for an intracranial tumor: An example of isoradiotopic response

Author

Maddalena La Montagna, Stefano Caccavale, Tobia Caccavale, Caccavale, S, Caccavale, T, and La Montagna, M

Subjects
medicine.medical_specialty, Letter in Response to Previous Publication in IJD®, Intracranial tumor, business.industry, medicine.medical_treatment, Dermatology, lcsh:RL1-803, medicine.disease, Radiation therapy, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, lcsh:Dermatology, Radiology, business, Morphea
Published
2017

48. A case of tuberculosis cutis colliquativa treated with rifampicin and isoniazid

Author

Lo Schiavo, Ada, Cozzi, Roberto, Alfano, Rossella, Romano, Francesca, La Montagna, Maddalena, Caccavale, Tobia, Capasso, Raffaella, Mea, Eugenia Elisabetta, Stefano Caccavale, LO SCHIAVO, Ada, Cozzi, R, Alfano, R, Romano, F, La Montagna, M, Caccavale, T, Capasso, R, Mea, Ee, and Caccavale, S.

Subjects
tuberculosis, Mycobacterium tuberculosis, antitubercular therapy, tuberculosis cutis colliquativa, immunosuppressive treatment, rifampicin, isoniazid
Abstract

none

49. Adolescence, imperceptible boundary between normality and pathology: A literature review

Author

Bove, Domenico, Bove, Rocco M., Stefano Caccavale, Bravaccio, Carmela, Marino, Maria, La Montagna, Maddalena, Bove, Domenico, Bove, Rocco M, Caccavale, Stefano, Bravaccio, Carmela, Marino, Maria, La Montagna, Maddalena, Bove, D, Bove, Rm, Caccavale, S, Bravaccio, C, Marino, M, and La Montagna, M

Abstract

A reorganization of the brain occurs in adolescence and it is documented by neuroimaging, neurophysiology and pathology of development. The high levels of neural plasticity allow the intellectual and emotional development during adolescence, a transition period of life full of physical and psychological changes. However, potentially dangerous agents could be the genesis of psychopathology of the adult and mental illness or distress. Adolescence is a crucial phase for the maturation of the brain. Therefore, future research should study how the environment affects and influences the function and the organization of the brain. Teenagers look for new experiences and strong emotions, sometimes endangering their health. Neuroscientific explanations have been proposed for the typical teenagers' behavior. In the postnatal period the highest density of gray matter can be found in the primary sensorimotor cortex, while prefrontal cortex matures later. Subcortical areas of the brain, especially the limbic system and the reward system, develop earlier; therefore, there is an imbalance between the more mature subcortical areas and the less mature prefrontal areas during adolescence. This could explain the typical behavior patterns of this period of life.

50. Gender Differences in the Pathogenesis and Risk Factors of Hepatocellular Carcinoma.

Author

Nevola R, Tortorella G, Rosato V, Rinaldi L, Imbriani S, Perillo P, Mastrocinque D, La Montagna M, Russo A, Di Lorenzo G, Alfano M, Rocco M, Ricozzi C, Gjeloshi K, Sasso FC, Marfella R, Marrone A, Kondili LA, Esposito N, Claar E, and Cozzolino D

Abstract

Several chronic liver diseases are characterized by a clear gender disparity. Among them, hepatocellular carcinoma (HCC) shows significantly higher incidence rates in men than in women. The different epidemiological distribution of risk factors for liver disease and HCC only partially accounts for these gender differences. In fact, the liver is an organ with recognized sexual dysmorphism and is extremely sensitive to the action of androgens and estrogens. Sex hormones act by modulating the risk of developing HCC and influencing its aggressiveness, response to treatments, and prognosis. Furthermore, androgens and estrogens are able to modulate the action of other factors and cofactors of liver damage (e.g., chronic HBV infection, obesity), significantly influencing their carcinogenic power. The purpose of this review is to examine the factors related to the different gender distribution in the incidence of HCC as well as the pathophysiological mechanisms involved, with particular reference to the central role played by sex hormones.

Published
2023
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