Search

Your search keyword '"Lähteenmäki, P. M. (Päivi M.)"' showing total 2 results
Start Over Author "Lähteenmäki, P. M. (Päivi M.)"
2 results on '"Lähteenmäki, P. M. (Päivi M.)"'

1. Early disc degeneration in radiotherapy-treated childhood brain tumor survivors

Author

Grahn, P. (Petra), Remes, T. (Tiina), Kivisaari, R. (Reetta), Suo-Palosaari, M. H. (Maria H.), Arikoski, P. M. (Pekka M.), Koskenkorva, P. K. (Päivi K. T.), Lähteenmäki, P. M. (Päivi M.), Lönnqvist, T. R. (Tuula R. I.), Ojaniemi, M. K. (Marja K.), Sirkiä, K. H. (Kirsti H.), Sutela, A. K. (Anna K.), Toiviainen-Salo, S.-M. (Sanna-Maria), Rantala, H. M. (Heikki M. J.), Harila, A. H. (Arja H.), Niinimäki, J. (Jaakko), Karppinen, J. (Jaro), Ahonen, M. (Matti), Grahn, P. (Petra), Remes, T. (Tiina), Kivisaari, R. (Reetta), Suo-Palosaari, M. H. (Maria H.), Arikoski, P. M. (Pekka M.), Koskenkorva, P. K. (Päivi K. T.), Lähteenmäki, P. M. (Päivi M.), Lönnqvist, T. R. (Tuula R. I.), Ojaniemi, M. K. (Marja K.), Sirkiä, K. H. (Kirsti H.), Sutela, A. K. (Anna K.), Toiviainen-Salo, S.-M. (Sanna-Maria), Rantala, H. M. (Heikki M. J.), Harila, A. H. (Arja H.), Niinimäki, J. (Jaakko), Karppinen, J. (Jaro), and Ahonen, M. (Matti)

Abstract

Background: Childhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. This study aimed to investigate lumbar disc degeneration in magnetic resonance imaging (MRI) in adult survivors of radiotherapy-treated childhood BT compared to age and sex-matched population controls. Methods: In this cross-sectional comparative study, 127 survivors were identified from hospital registries. After a mean follow-up of 20.7 years (range 5–33.1), 67 survivors (mean age 28.4, range 16.2–43.5) were investigated with MRI and compared to 75 sex-matched population-based controls. Evaluated MRI phenotypes included Pfirrmann grading, intervertebral disc protrusions, extrusions, and high-intensity-zone-lesions (HIZ). Groups were also compared for known risk factors of lumbar intervertebral disc (IVD) degeneration. Results: Childhood BT survivors had higher Pfirrmann grades than controls at all lumbar levels (all p < 0.001). Lumbar disc protrusions at L4-5 (p = 0.02) and extrusions at L3-4 (p = 0.04), L4-5 (p = 0.004), and L5-S1 (p = 0.01) were significantly more common in the BT group compared to the control. The survivor cohort also had significantly more HIZ-lesons than the controls (n=13 and n=1, p=0.003). Age at diagnosis was associated with lower degree of IVD degeneration (p < 0.01). Blood pressure correlated with IVD degeneration (P < 0.05). Conclusions: Signs of early disc degeneration related to tumor treatment can be seen in the IVDs of survivors. Disc degeneration was more severe in children treated in adolescence.

Published
2023

2. Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors

Author

Remes, T. M. (Tiina M.), Hovén, E. (Emma), Ritari, N. (Niina), Pohjasniemi, H. (Heli), Puosi, R. (Riina), Arikoski, P. M. (Pekka M.), Arola, M. O. (Mikko O.), Lähteenmäki, P. M. (Päivi M.), Lönnqvist, T. R. (Tuula R. I.), Ojaniemi, M. K. (Marja K.), Riikonen, V. P. (V. Pekka), Sirkiä, K. H. (Kirsti H.), Winqvist, S. (Satu), Rantala, H. M. (Heikki M. J.), Harila, M. (Marika), and Harila-Saari, A. H. (Arja H.)

Subjects
radiation, employment, neurocognitive impairment, brain tumor, social status
Abstract

Background: Little is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status. Methods: Neurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5–33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered. Results: Survivors’ (median age: 27 years [range: 16–43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49–121) and 87 (range: 43–119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, −3.5 SD [range: −25.0 to 1.3 SD]), and processing speed and attention (median z score, −2.5 SD [range: −24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently. Conclusions: Radiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results