15,009 results on '"LU Xin"'
Search Results
2. Dual role of targeting NAE1 in nasopharyngeal carcinoma: Antitumor effects yet inducing radiotherapy resistance
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Qinsong Liu, Lu Xin, Xiaoning Ma, and Yong Yuan
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NAE1 ,MLN4924 ,Nasopharyngeal carcinoma ,Radiosensitivity ,Cell cycle ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background and objectives: The inhibitor MLN4924 of Neural Precursor Cell-Expressed Developmentally Down-Regulated 8 (NEDD8) Activating Enzyme 1 (NAE1) has been found to suppress the growth of nasopharyngeal carcinoma (NPC). However, its effect on NPC's radiotherapy sensitivity remains unclear. Methods: By integrating single-cell RNA sequencing and bulk RNA sequencing, we predict the impact of NAE1 on the cell cycle, cell death, and its relationship with radiotherapy sensitivity and prognosis in NPC. The effect of inhibiting NAE1 on NPC cell behavior and radiation sensitivity is explored through MLN4924 intervention in vitro and in vivo. We construct a prognosis prediction model based on NAE1 using machine learning methods and validate the efficacy of NAE1 and the model in clinical cohorts. Results: NPC patients with high NAE1 expression have better prognosis and higher expression in the radiotherapy-sensitive group. Inhibiting NAE1 with MLN4924 causes cell cycle arrest in NPC cells, preventing them from entering the G2/M phase, thereby inhibiting proliferation but not affecting migration and metastasis. However, in vitro and in vivo experiments demonstrate that inhibiting NAE1 with MLN4924 leads to increased resistance of NPC to radiation. Conclusions: Targeting NAE1 for NPC treatment may have dual effects, inhibiting NPC proliferation while also increasing radiation resistance.
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- 2024
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3. Transformer state detection and assessment method based on voiceprint compression and cost-sensitive techniques
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HU Zhaoyu, LI Zhe, CHEN Haiwei, and LU Xin
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transformer detection ,acoustic pattern recognition ,acoustic pattern compression ,cost sensitivity ,convolutional neural networks ,pattern recognition ,Applications of electric power ,TK4001-4102 - Abstract
Voiceprint detection technology can assist inspectors in assessing the state of transformers. A method for detecting and assessing transformer states based on voiceprint compression and cost-sensitive techniques is proposed. The method first extracts voiceprint features from transformer audio, then filters and compresses these features in the frequency domain. Subsequently, a convolutional neural network is employed to evaluate the transformer′s state, incorporating a cost-sensitive loss function to enhance attention towards difficult samples. Using a 35 kV transformer as the experimental subject, transformer audio data is collected through on-site recordings, simulated experiments and sample augmentation. Test results demonstrate that the proposed method reduces the voiceprint dimensionality from 1 025 to 80, decreasing computational complexity and video memory usage to 8.1% and 7.7% of the original 1 025 dimensions, respectively. Simultaneously, the proposed method achieves a voiceprint recognition accuracy of 83.5% and improves the recall rate of the most challenging short-circuit current anomaly from 48.2% to 63.6%.
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- 2024
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4. Cyclin B2 impairs the p53 signaling in nasopharyngeal carcinoma
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Qinsong Liu, Yong Yuan, Xiaofen Shang, and Lu Xin
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JMJD6 ,CCNB2 ,p53 pathway ,Methylation ,Nasopharyngeal carcinoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Cyclin B2 (CCNB2), a member of the cyclin family, is an oncogene in multiple cancers, including nasopharyngeal carcinoma (NPC). However, the epigenetics mechanism for CCNB2 overexpression in NPC remains unclear. This study dissects the regulatory role of CCNB2 in NPC and the molecular mechanism. Methods Differentially methylated genes (DMG) and differentially expressed genes (DEG) were screened out in GSE52068 and GSE13597 databases, respectively, and candidate targets were identified by the Venn diagram. GO annotation and pathway enrichment analyses were performed on selected DMG and DEG, and a PPI network was constructed to pinpoint hub genes. PCR and qMSP were conducted to detect the expression and methylation of CCNB2 in cells. The siRNA targeting CCNB2 was transfected into NPC cells, and the migration, proliferation, cell cycle, epithelial-mesenchymal transition (EMT), tumorigenesis, and metastasis were examined. The upstream factor responsible for CCNB2 overexpression in NPC was explored. The p53 activity in NPC cells was assessed using western blot analysis. Results CCNB2 showed hypomethylation and overexpression in NPC. CCNB2 silencing inhibited cell migration, proliferation, cell cycle entry, and EMT. JMJD6 was overexpressed in NPC and upregulated CCNB2 through demethylation. JMJD6 reversed the effects of CCNB2 downregulation, resulting in elevated cellular activity in vitro and tumorigenic and metastatic activities in vivo. CCNB2 blocked the p53 pathway, while the p53 pathway inhibitor reversed the effect of CCNB2 silencing to increase the activity of NPC cells. Conclusions JMJD6 enhanced CCNB2 transcription by demethylating CCNB2, thereby repressing the p53 pathway and promoting NPC progression.
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- 2024
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5. 5 Cases Analysis of Pachydermoperiostosis Complicated with Synovitis
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LU Xin, YANG Bo, and ZHANG Jianguo
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pachydermoperiostosis ,clinical characteristics ,drug therapy ,surgery ,Medicine - Abstract
Objective To analyze the clinical characteristics, treatments and prognosis of pachydermoperiostosis (PDP) with synovitis, and to improve clinicians′ understanding of PDP. Methods The clinical data of 5 patients diagnosed with PDP in Peking Union Medical College Hospital from January 2010 to June 2015 were retrospectively analyzed. Results Among the 5 patients in this study, all were male, with an average age of (24.2±3.8)years old. The main manifestations of PDP were joint swelling and pain and skin thickening. In this study, all 5 patients were treated with medication, including non-steroidal anti-inflammatory drugs, glucocorticoids, and immunosuppressants, and 4 patients were treated with arthroscopic minimally invasive synovectomy. Their symptoms gradually improved and controlled. The last patient′s symptoms of synovitis were mild and significantly relieved after conservative treatment Conclusions The diagnosis of PDP is still challenging. Symptoms can be alleviated, and the progression of the disease can be basically controlled after active drug therapy and surgical mitigation measures.
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- 2023
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6. Metabolic reprogramming of the ovarian cancer microenvironment in the development of antiangiogenic resistance
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Yue Huiran and Lu Xin
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ovarian cancer ,tumor microenvironment ,antiangiogenic therapy ,metabolism ,Biochemistry ,QD415-436 ,Genetics ,QH426-470 - Abstract
Antiangiogenic therapies, such as treatment with bevacizumab, display modest survival benefits in ovarian cancer (OC) patients. After a transient response, the upregulation of compensatory proangiogenic pathways and the adoption of alternative vascularization processes lead to the development of resistance. Considering the high mortality rate of OC, there is an urgent need to uncover the underlying mechanisms of antiangiogenic resistance for the development of novel and effective treatment strategies. Recent investigations have confirmed that metabolic reprogramming in the tumor microenvironment (TME) exerts an essential effect on tumor aggressiveness and angiogenesis. In this review, we provide an overview of the metabolic crosstalk between OC and the TME, highlighting the regulatory mechanisms underlying the development of antiangiogenic resistance. Metabolic interventions may interrupt this complex and dynamic interactive network, providing a promising therapeutic option to improve clinical outcome in OC patients.
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- 2023
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7. Updating Method of Open-pit Mine Digital Map Based on Vehicle-cloud Collaboration
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LI Haoran, ZHANG Li, LU Xin, WANG Xiaowei, OUYANG Wenjie, and QIN Hongmao
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vehicle-cloud collaboration ,autonomous driving ,map updating ,high-definition digital map ,open-pit mine ,Control engineering systems. Automatic machinery (General) ,TJ212-225 ,Technology - Abstract
High-definition digital map is the foundation of autonomous driving technology, which provides precise location information for autonomous vehicles. However, with the change of environment and the passage of time, the fidelity performance of unstructured road map will gradually decline. Therefore, this paper proposes a digital map updating method of open-pit mine based on vehicle-cloud collaboration to effectively improve the efficiency of map updating. Firstly, a three-layer map model structure is constructed to ensure the integrity of map updating of open-pit mine. Then, a track-based map updating method is proposed for many scenarios of open-pit mines. Meanwhile, a map updating framework based on vehicle-cloud collaboration is designed to improve the efficiency of automatic driving map updating in open-pit mines. Experimental results show that this method can effectively reduce the map updating delay. Compared with the single-vehicle mode, the average map updating delay is reduced by 75%. At the same time, the relative error of map updating is reduced, and the overall accuracy is increased by 10%, which meets the requirements of map fidelity.
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- 2022
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8. Crystal structure of diiodido-bis(6,6′-dimethoxy-2,2′-(ethane-1,2-diylbis(nitrilomethanylylidene)) diphenolato)tricadmium(II), C36H36Cd3I2N4O8
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Hu Jin and Lu Xin-Hua
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2192002 ,Physics ,QC1-999 ,Crystallography ,QD901-999 - Abstract
C36H36Cd3I2N4O8, orthorhombic, Pbca (no. 61), a = 18.909(4) Å, b = 16.149(3) Å, c = 26.050(5) Å, V = 7955(3) Å3, Z = 8, Rgt (F) = 0.0439, wRref (F 2) = 0.0752, T = 293(2) K.
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- 2022
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9. Research on Influencing Factors of Box Dimension by Simulating Grain Storage Accumulation
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CHEN Xiao-yu and LU Xin
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box dimension ,fractal theory ,porous media ,grain pile ,permeability ,Food processing and manufacture ,TP368-456 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
In order to study the influencing factors of grain pile permeability, the influencing factors of fractal dimension closely related to permeability were explored based on fractal theory. Firstly, EDEM software is used to simulate the formation process of grain pile to verify the accuracy of the box dimension detection method of image binary method. Then this method is used to measure the analytical dimension of grain pile section, and explore the influence of grain warehousing speed and particle uniformity on fractal dimension. The results show that the fractal dimension of grain pile is positively correlated with permeability, and a larger permeability of grain pile is conducive to the temperature control of subsequent grain pile and the reduction of mechanical ventilation and cooling energy consumption. The storage speed of grain stockpile has a great influence on the permeability of grain stockpile. It is found that when the speed of a single grain conveyor is 14.3 t/h, the fractal dimension is large and the permeability is large, and the efficiency of grain stockpile is not affected; The stacking mode of grain pile has less impact on permeability, and the natural stacking mode of grain conveyor is more beneficial to grain. The calculation results have reference significance for guiding grain warehousing.
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- 2022
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10. Uncertainty evaluation of cadmium content in kelp (Laminaria japonica) by graphite furnace atomic absorption spectrometry
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LIU Lan-ying, LU Xin, LI Ying, and LUO Tu-yan
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uncertainty ,cadmium ,kelp ,graphite furnace atomic absorption spectrometry ,Food processing and manufacture ,TP368-456 - Abstract
Objective: To improve the accuracy of the results of cadmium (Cd) content in kelp (Laminaria japonica) by graphite furnace atomic absorption spectrometry (GF-AAS). Methods: The concentration of Cd element in kelp sample was measured by using GF-AAS after microwave digestion according to the standard of GB 5009.15—2014. Combining with the experimental process and mathematical model, the possible sources of measurement uncertainty were firstly identified, then the components of each standard uncertainties were calculated, and finally each parameter of uncertainties was synthesized, and the whole uncertainty was evaluated. Results: when the value of Cd concentration in kelp was 0.202 mg/kg, the expanded uncertainty was 0.008 mg/kg (k=2). Conclusion: The uncertainty of the method is mainly derived from the determination of Cd concentration in the sample solution, which is basically introduced by standard working solution preparation. Moreover, the uncertainty caused by the sample recovery rate is also large. So the quality control of the parameter of uncertainties should be strengthened in the future.
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- 2022
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11. An Enhancement and Detection Method for a Glue Dispensing Image Based on the CycleGAN Model
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Zhang Xing-Wei, Zhang Ke, Xie Ling-Wang, Zhao Yong-Jie, and Lu Xin-Jian
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CycleGAN ,detection ,glue dispensing ,image enhancement ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
During the active alignment focusing process of car camera assembly, lenses and holders need to be gummed by creamy white and translucent UV glue. The quality of glue dispensing can directly influence the performance of car cameras. Because of the translucency of UV glue, the glue dispensing image may present a low contrast situation, which increases the difficulty of vision detection. This paper proposes a method based on CycleGAN to enhance the glue dispensing image and effectively overcome the problems of blurred and low contrast edges. First, the glue part of the image is segmented into twenty regions. Second, the VGG16 model is used to divide the abovementioned twenty regions into high-contrast images and low-contrast images. Next, the CycleGAN model is trained to enhance the low-contrast images, and then convert them to high-contrast images. Finally, glue contours are extracted by using thresholding segmentation and edge detection to ensure that the quality of glue dispensing can be detected. The success rates of the VGG16 model and the CycleGAN model are 96% and 58%, respectively. The results show that the proposed method can effectively enhance the low contrast part of the glue region and improve the detection accuracy. Specifically, it can increase the gray value difference between the glue and the background from 20 to 55, while the background is substantially retained. The detailed information of the edges of the images is enriched. The accuracy of glue edge extraction can be increased to 99%, which is an approximately 75% improvement compared to the methods without enhancement.
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- 2022
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12. Label-Free Assessment of the Drug Resistance of Epithelial Ovarian Cancer Cells in a Microfluidic Holographic Flow Cytometer Boosted through Machine Learning
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Lu Xin, Wen Xiao, Leiping Che, JinJin Liu, Lisa Miccio, Vittorio Bianco, Pasquale Memmolo, Pietro Ferraro, Xiaoping Li, and Feng Pan
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Chemistry ,QD1-999 - Published
- 2021
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13. Multi-object Tracking by Detection and Query: an efficient end-to-end manner
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Jia, Shukun, Cao, Yichao, Yang, Feng, Lu, Xin, and Lu, Xiaobo
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Multi-object tracking is advancing through two dominant paradigms: traditional tracking by detection and newly emerging tracking by query. In this work, we fuse them together and propose the tracking-by-detection-and-query paradigm, which is achieved by a Learnable Associator. Specifically, the basic information interaction module and the content-position alignment module are proposed for thorough information Interaction among object queries. Tracking results are directly Decoded from these queries. Hence, we name the method as LAID. Compared to tracking-by-query models, LAID achieves competitive tracking accuracy with notably higher training efficiency. With regard to tracking-by-detection methods, experimental results on DanceTrack show that LAID significantly surpasses the state-of-the-art heuristic method by 3.9% on HOTA metric and 6.1% on IDF1 metric. On SportsMOT, LAID also achieves the best score on HOTA metric. By holding low training cost, strong tracking capabilities, and an elegant end-to-end approach all at once, LAID presents a forward-looking direction for the field.
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- 2024
14. A multi-faceted view of the X-ray spectral variability in Seyfert galaxy Ark 120
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Ren, Lu-Xin, Wang, Jun-Xian, and Kang, Jia-Lai
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
Utilizing a range of techniques including multi-band light curves, softness ratio analysis, structure functions, rms spectra, cross-correlation functions, and ratios of spectra from different intervals, we present a comprehensive study of the complex X-ray spectral variability in Seyfert 1 galaxy Ark 120, through re-analyzing its six XMM-Newton observations taken between 2003 and 2014. We find a clear ''softer-when-brighter" trend in the 2--10 keV power-law component over long timescales, with this trend being timescale dependent, as it is much weaker on shorter timescales, similar to that previously detected in NGC 4051. Notably, a rare ''harder-when-brighter" trend is observed during one exposure, indicating dynamic changes in the spectral variability behavior of the power-law component. This exceptional exposure, with the spectral variability indeed marked by a power-law pivoting at an unusually low energy of ~ 2 keV, suggests intricate variations in the thermal Comptonization processes within the corona. Furthermore, when the data below 2 keV are included, we identify that the soft excess component adds significant complexity to the spectral variability, such as evidenced by a transition from ''harder-when-brighter'' to ''softer-when-brighter'' during another single exposure. Such extra complexity arises because the variability of the soft excess sometimes follows and sometimes does not follow the changes in the power-law component. Our findings underscore the necessity of applying multiple analytic techniques to fully capture the multifaceted spectral variability of AGNs., Comment: 13 pages, 11 figures, submitted. Comments are very welcome!
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- 2024
15. New bounds of two hypergraph Ramsey problems
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Fan, Chunchao, Hu, Xinyu, Lin, Qizhong, and Lu, Xin
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Mathematics - Combinatorics - Abstract
We focus on two hypergraph Ramsey problems. First, we consider the Erd\H{o}s-Hajnal function $r_k(k+1,t;n)$. In 1972, Erd\H{o}s and Hajnal conjectured that the tower growth rate of $r_k(k+1,t;n)$ is $t-1$ for each $2\le t\le k$. To finish this conjecture, it remains to show that the tower growth rate of $r_4(5,4;n)$ is three. We prove a superexponential lower bound for $r_4(5,4;n)$, which improves the previous best lower bound $r_4(5,4;n)\geq 2^{\Omega(n^2)}$ from Mubayi and Suk (\emph{J. Eur. Math. Soc., 2020}). Second, we prove an upper bound for the hypergraph Erd\H{o}s-Rogers function $f^{(k)}_{k+1,k+2}(N)$ that is an iterated $(k-3)$-fold logarithm in $N$ for each $k\geq 5$. This improves the previous upper bound that is an iterated $(k-13)$-fold logarithm in $N$ for $k\ge14$ due to Mubayi and Suk (\emph{J. London Math. Soc., 2018}), in which they conjectured that $f^{(k)}_{k+1,k+2}(N)$ is an iterated $(k-2)$-fold logarithm in $N$ for each $k\ge3$., Comment: 18 pages
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- 2024
16. Ferrovalley Physics in Stacked Bilayer Altermagnetic Systems
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Li, Yun-Qin, Zhang, Yu-Ke, Lu, Xin-Le, Shao, Ya-Ping, Bao, Zhi-qiang, Zheng, Jun-Ding, Tong, Wen-Yi, and Duan, Chun-Gang
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Condensed Matter - Materials Science - Abstract
As an emerging magnetic phase, altermagnets with compensated magnetic order and non-relativistic spin-splitting have attracted widespread attention. Currently, strain engineering is considered to be an effective method for inducing valley polarization in altermagnets, however, achieving controllable switching of valley polarization is extremely challenging. Herein, combined with tight-binding model and first-principles calculations, we propose that interlayer sliding can be used to successfully induce and effectively manipulate the large valley polarization in altermagnets. Using Fe2MX4 (M = Mo, W; X = S, Se or Te) family as examples, we predict that sliding induced ferrovalley states in such systems can exhibit many unique properties, including the linearly optical dichroism that is independent of spin-orbit coupling, and the anomalous valley Hall effect. These findings imply the correlation among spin, valley, layer and optical degrees of freedom that makes altermagnets attractive in spintronics, valleytronics and even their crossing areas.
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- 2024
17. PEAR: Position-Embedding-Agnostic Attention Re-weighting Enhances Retrieval-Augmented Generation with Zero Inference Overhead
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Tan, Tao, Qian, Yining, Lv, Ang, Lin, Hongzhan, Wu, Songhao, Wang, Yongbo, Wang, Feng, Wu, Jingtong, Lu, Xin, and Yan, Rui
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Large language models (LLMs) enhanced with retrieval-augmented generation (RAG) have introduced a new paradigm for web search. However, the limited context awareness of LLMs degrades their performance on RAG tasks. Existing methods to enhance context awareness are often inefficient, incurring time or memory overhead during inference, and many are tailored to specific position embeddings. In this paper, we propose Position-Embedding-Agnostic attention Re-weighting (PEAR), which enhances the context awareness of LLMs with zero inference overhead. Specifically, on a proxy task focused on context copying, we first detect heads which suppress the models' context awareness thereby diminishing RAG performance. To weaken the impact of these heads, we re-weight their outputs with learnable coefficients. The LLM (with frozen parameters) is optimized by adjusting these coefficients to minimize loss on the proxy task. As a result, the coefficients are optimized to values less than one, thereby reducing their tendency to suppress RAG performance. During inference, the optimized coefficients are fixed to re-weight these heads, regardless of the specific task at hand. Our proposed PEAR offers two major advantages over previous approaches: (1) It introduces zero additional inference overhead in terms of memory usage or inference time, while outperforming competitive baselines in accuracy and efficiency across various RAG tasks. (2) It is independent of position embedding algorithms, ensuring broader applicability., Comment: preprint
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- 2024
18. Analysis of a dislocation model for earthquakes
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Liu, Jing, Lu, Xin Yang, and Walkington, Noel J
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Mathematics - Numerical Analysis - Abstract
Approximation of problems in linear elasticity having small shear modulus in a thin region is considered. Problems of this type arise when modeling ground motion due to earthquakes where rupture occurs in a thin fault. It is shown that, under appropriate scaling, solutions of these problems can be approximated by solutions of a limit problem where the fault region is represented by a surface. In a numerical context this eliminates the need to resolve the large deformations in the fault; a numerical example is presented to illustrate efficacy of this strategy.
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- 2024
19. Tuning competition between charge order and superconductivity in the square-lattice $t$-$t'$-$J$ model
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Lu, Xin, Guo, Huaiming, Chen, Wei-Qiang, Sheng, D. N., and Gong, Shou-Shu
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Condensed Matter - Strongly Correlated Electrons - Abstract
Recently, a flurry of works have found strong competition between charge density wave (CDW) and superconductivity (SC) in the doped Hubbard and $t$-$J$ models on the square lattice. Interestingly, some recent results suggest that the electron-phonon coupling may suppress CDW order and enhance SC. In this work, we consider the square-lattice Hubbard model with the Holstein or Su-Schrieffer-Heeger electron-phonon coupling at the large-$U$ and antiadiabatic (infinite phonon frequency) limit, which gives an effective $t$-$J$ model with either a density attractive interaction $V$ or a $J_P$ term that contributes a larger spin exchange and a density repulsive interaction. To explore how these effective couplings may suppress CDW and give a SC, we implement the density matrix renormalization group simulation on the $t$-$t'$-$J$ model with $V$ or $J_P$ coupling. We focus on the {\it six-leg} cylinder system with the next-nearest-neighbor hopping $t'$, which hosts partially filled stripe and $d$-wave SC in phase diagram. By tuning $t'/t > 0$ and $V$ or $J_P$, we establish two quantum phase diagrams. In the SC phases, the increased $V$ or $J_P$ coupling can enhance the quasi-long-range SC order, consistent with some previous findings. Nonetheless, no SC emerges when the partially filled stripe phase disappears with increased $V$ or $J_P$. Instead, the system has a transition to either a phase-separation-like regime or a filled stripe phase. On the other hand, with increased $t'/t$, not only the partially filled stripe but the phase separation and filled stripe can also be tuned to SC phase. Our results suggest that although $V$ and $J_P$ couplings may strengthen hole binding, the hole dynamics controlled by $t'/t$ appears to play more crucial role for obtaining a SC in $t$-$J$ model., Comment: 12 pages, 10 figures
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- 2024
20. Tuning Charged Localized Excitons in Monolayer WSe2 via Coupling to a Relaxor Ferroelectric
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Zhou, Qiaohui, Wang, Fei, Soleymani, Ali, Watanabe, Kenji, Taniguchi, Takashi, Wei, Jiang, and Lu, Xin
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The discovery of single photon emitters (SPEs) in two-dimensional (2D) layered materials has greatly inspired numerous studies towards utilizing the system for quantum science and technology. Thus, the dynamic control of SPEs, including neutral and charged emitters, is highly desirable. In addition to the electric control, strain tuning is particularly attractive for the 2D materials since it can activate SPEs which are formed upon localizing free excitons. While strain engineering has been demonstrated for free and neutral localized excitons, few were shown on charged localized excitons which require an additional gate control. In this article, we show the strain-tunable charged localized excitons by transferring a top-gated monolayer semiconductor on a relaxor ferroelectric. Importantly, we unveil an enhanced interaction between the localized oscillating dipoles and the nanodomains. We further demonstrate the strain-dependent circular polarization and tunable rates of energy shifts under a magnetic field. Our results imply that the integration of 2D materials with relaxor ferroelectrics provides a rich platform for nanophotonics and quantum photonics., Comment: 11 pages, 4 figures
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- 2024
21. Preparation of Certified Reference Materials for Soil Limit Water Content
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ZHAO Xiu-feng, GAO Xiao-li, CAO Lei, CAO Jing-yang, and LU Xin-cheng
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soil ,limit water content ,reference material ,certified value ,uncertainty ,Geology ,QE1-996.5 ,Ecology ,QH540-549.5 - Abstract
BACKGROUND Soil limit water content is an important basis for fine-grained soil classification and engineering property evaluation. Additionally, it is an important evaluation index for clay exploration and industrial utilization. Inaccurate test results of soil limit water content may lead to serious engineering safety accidents and personal and economic property losses. Certified reference materials (CRMs) are important for ensuring the accuracy, comparability, and effectiveness of the analyzed data. However, no certified reference materials for soil limit water content exist; therefore, the preparation of CRMs for the soil limit water content holds great significance. OBJECTIVES To prepare CRMs of soil limit water content. METHODS In strict accordance with the specifications and standards, such as "Technical Specifications for First-Class Reference Materials" (JJF 1006-1994) and "General Principles and Statistical Principles for the Valuation of Reference Materials" (JJF 1343-2012), five standard materials of soil limit water content (GBW07969, GBW07970, GBW07971, GBW07972, and GBW07973) have been developed. These samples were collected from Huaibei of Anhui province, Datong of Shanxi province, and Nanjing of Jiangsu province. After artificial crushing, drying, and sterilization, the samples were finely crushed to less than 0.25mm by a large ball mill. After particle size analysis, the samples were bottled and numbered in a clean room. RESULTS Twenty-five bottles of each sample were randomly selected for homogeneity testing. All the measured values of F were less than F0.05 (24, 25)=1.96, and the relative standard deviation (RSD) was between 1.16% and 2.67%, which indicated good uniformity. There were no significant differences in the long-term stability test (12months) and the short-term stability test (60℃, -20℃). The certified values of 10mm liquid limit, plastic limit, and plasticity index were 26.3%-39.9%, 16.9%-22.2%, and 10.0%-17.7%, respectively. The gradient series was significant, which included silty clayey and clayey type of soils. CONCLUSIONS Five first classes of National CRMs (GBW07969, GBW07970, GBW07971, GBW07972, and GBW07973) of soil limit water content were successfully prepared. This series of CRMs can be used for calibration of instruments and equipment, quality control, capability verification, and other technical quality activities, which provide a guarantee for the accuracy requirements of soil limit water test data in hydraulic environment geological exploration, geotechnical engineering exploration, clay mine exploration, and other related disciplines.
- Published
- 2021
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22. Analysis of Runner Dynamics of Reversible Hydraulic Turbine by Alternating Fluid–Solid Action
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Lu Xin, Qifei Li, Zhenggui Li, Gengda Xie, and Qifan Wang
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water pump turbines ,bidirectional fluid–structure interaction ,modal analysis ,eddy ,vibration ,General Works - Abstract
In order to study the effect of alternating fluid–solid action on the dynamic characteristics of the runner of a reversible hydraulic turbine, a reversible hydraulic turbine model is used as the research object, and the two-way fluid–solid coupling method is used to iteratively calculate and analyze the fluid and structural equations to obtain the effect of the reversible hydraulic turbine on the runner under the two-way fluid–solid coupling action of the runner of the reversible hydraulic turbine under typical operating conditions. The results showed that under the influence of a high-speed water ring area under a certain working condition, the incoming flow direction forms a certain impulse angle with the blade, and under the joint action of the runner rotating at high speed, the vortex structure is generated in the blade area, and the speed change in the inlet area has a large random fluctuation, which is not conducive to the stability of the runner area and causes a strong pressure pulsation at the inlet. Under different working conditions, the runner stress area phenomenon is obvious, concentrated in the runner blade inlet side and the upper crown, lower ring connection. The maximum deformation region appears in the lower region of the middle of the blade inlet. The comparison of the modal analysis shows that the dynamic stress frequency caused by the dynamic interference is very unlikely to trigger the resonance of the runner.
- Published
- 2022
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23. The left common iliac vein area: Analysis of chronic venous disease patients with and without MTS
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Yang Cheng-Hao, Lu Xin-Wu, Huang Xin-Tian, Liu Xiao-Bing, Ye Kai-Chuang, Zhao Zhen, Wang Xu-Hui, Wang Peng-Hui, and Yin Min-Yi
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chronic venous disease ,computer tomography venography ,left common iliac vein ,may–thurner syndrome ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
OBJECTIVE: To analyze the normal reference left common iliac vein (LCIV) area in chronic venous disease (CVD) patients with or without May–Thurner syndrome (MTS) and its relevant influencing factors. MATERIALS AND METHODS: A prospective analysis of patients with left lower extremity CVD was conducted in a single institution from January to August 2019. A total of 326 patients, 98 with MTS and 228 without MTS after computed tomography (CT) venography, were finally enrolled in this study, and their basic information was recorded. MTS cases were distinguished from non-MTS cases by calculating area stenosis rate with CT three-dimensional reconstruction. The reference area of LCIV was also defined and calculated to analyze its coefficient of variation and relationship with influencing factors in patients with and without MTS. RESULTS: Ninety-eight cases of MTS and 228 cases of non-MTS were finally analyzed. In the MTS group, the mean area of reference LCIV was significantly lower (116.29 ± 53.17 mm2 vs. 160.44 ± 52.99 mm2, P < 0.01) and showed greater variability (0.21 ± 0.13 vs. 0.16 ± 0.08, P = 0.04) compared with non-MTS group. Obesity radio was significantly higher in non-MTS group (28.5% vs. 16.3%, P = 0.03). In both MTS and non-MTS groups, the increase of body mass index (BMI) was generally associated with statistically significant increases in the LCIV area (P = 0.002 and P = 0.005), while other factors showed no statistically significant correlation. CONCLUSIONS: The reference area of LCIV was redefined in this study. We found that the increase of the LCIV area in both MTS and non-MTS groups was correlated with an increase in BMI. Furthermore, a smaller area of reference LCIV and more variability in the LCIV area were found in the MTS group in contrast to the non-MTS group.
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- 2021
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24. Improved Doubly Robust Estimation in Marginal Mean Models for Dynamic Regimes
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Sun Hao, Ertefaie Ashkan, Lu Xin, and Johnson Brent A.
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causal inference ,informative eligibility ,missing data ,treatment competing events ,92b15 ,Mathematics ,QA1-939 ,Probabilities. Mathematical statistics ,QA273-280 - Abstract
Doubly robust (DR) estimators are an important class of statistics derived from a theory of semiparametric efficiency. They have become a popular tool in causal inference, including applications to dynamic treatment regimes. The doubly robust estimators for the mean response to a dynamic treatment regime may be conceived through the augmented inverse probability weighted (AIPW) estimating function, defined as the sum of the inverse probability weighted (IPW) estimating function and an augmentation term. The IPW estimating function of the causal estimand via marginal structural model is defined as the complete-case score function for those subjects whose treatment sequence is consistent with the dynamic regime in question divided by the probability of observing the treatment sequence given the subject's treatment and covariate histories. The augmentation term is derived by projecting the IPW estimating function onto the nuisance tangent space and has mean-zero under the truth. The IPW estimator of the causal estimand is consistent if (i) the treatment assignment mechanism is correctly modeled and the AIPW estimator is consistent if either (i) is true or (ii) nested functions of intermediate and final outcomes are correctly modeled.
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- 2020
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25. GSpect: Spectral Filtering for Cross-Scale Graph Classification
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Zhang, Xiaoyu, Yang, Wenchuan, Feng, Jiawei, Dai, Bitao, Bu, Tianci, and Lu, Xin
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Social and Information Networks - Abstract
Identifying structures in common forms the basis for networked systems design and optimization. However, real structures represented by graphs are often of varying sizes, leading to the low accuracy of traditional graph classification methods. These graphs are called cross-scale graphs. To overcome this limitation, in this study, we propose GSpect, an advanced spectral graph filtering model for cross-scale graph classification tasks. Compared with other methods, we use graph wavelet neural networks for the convolution layer of the model, which aggregates multi-scale messages to generate graph representations. We design a spectral-pooling layer which aggregates nodes to one node to reduce the cross-scale graphs to the same size. We collect and construct the cross-scale benchmark data set, MSG (Multi Scale Graphs). Experiments reveal that, on open data sets, GSpect improves the performance of classification accuracy by 1.62% on average, and for a maximum of 3.33% on PROTEINS. On MSG, GSpect improves the performance of classification accuracy by 15.55% on average. GSpect fills the gap in cross-scale graph classification studies and has potential to provide assistance in application research like diagnosis of brain disease by predicting the brain network's label and developing new drugs with molecular structures learned from their counterparts in other systems.
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- 2024
26. Estimation and inference of average treatment effects under heterogeneous additive treatment effect model
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Lu, Xin, Li, Hongzi, and Liu, Hanzhong
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Statistics - Methodology - Abstract
Randomized experiments are the gold standard for estimating treatment effects, yet network interference challenges the validity of traditional estimators by violating the stable unit treatment value assumption and introducing bias. While cluster randomized experiments mitigate this bias, they encounter limitations in handling network complexity and fail to distinguish between direct and indirect effects. To address these challenges, we develop a design-based asymptotic theory for the existing Horvitz--Thompson estimators of the direct, indirect, and global average treatment effects under Bernoulli trials. We assume the heterogeneous additive treatment effect model with a hidden network that drives interference. Observing that these estimators are inconsistent in dense networks, we introduce novel eigenvector-based regression adjustment estimators to ensure consistency. We establish the asymptotic normality of the proposed estimators and provide conservative variance estimators under the design-based inference framework, offering robust conclusions independent of the underlying stochastic processes of the network and model parameters. Our method's adaptability is demonstrated across various interference structures, including partial interference and local interference in a two-sided marketplace. Numerical studies further illustrate the efficacy of the proposed estimators, offering practical insights into handling network interference.
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- 2024
27. Orbital magnetoelectric coupling of three dimensional Chern insulators
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Lu, Xin, Jiang, Renwen, and Liu, Jianpeng
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Orbital magnetoelectric effect is closely related to the band topology of bulk crystalline insulators. Typical examples include the half quantized Chern-Simons orbital magnetoelectric coupling in three dimensional (3D) axion insulators and topological insulators, which are the hallmarks of their nontrivial bulk band topology. While the Chern-Simons coupling is well defined only for insulators with zero Chern number, the orbital magnetoelectric effects in 3D Chern insulators with nonzero (layer) Chern numbers are still open questions. In this work, we propose a never-mentioned quantization rule for the layer-resolved orbital magnetoelectric response in 3D Chern insulators, the gradient of which is exactly quantized in unit of $e^2/h$. By theoretical analysis and numerical simulations, we demonstrate that the quantized orbital magnetoelectric response remains robust for various types of interlayer hoppings and stackings, even against disorder and lack of symmetries. We argue that the robustness has a topological origin and protected by layer Chern number. It is thus promising to observe the proposed quantized orbital magnetoelectric response in a slab of 3D Chern insulator thanks to recent experimental developments., Comment: main text: 5 pages, 1 figure and 5 tables; SI: 15 pages, 5 figures and 2 tables
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- 2024
28. Kagome materials $A$V$_3$Sb$_5$ ($A$=K,Rb,Cs): pairing symmetry and pressure-tuning studies
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Zhou, Yuwei, Ye, Ge, Luo, Shuaishuai, Song, Yu, Lu, Xin, and Yuan, Huiqiu
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
The vanadium-based kagome metals $A$V$_3$Sb$_5$ ($A$ = K, Rb, and Cs) host a superconducting ground state that coexists with an unconventional charge density wave (CDW). The CDW state exhibits experimental signatures of chirality, electronic nematicity, and time-reversal-symmetry-breaking, raising the questions whether the superconductivity (SC) in $A$V$_3$Sb$_5$ may also be unconventional, how SC interplays with CDW, and how the two orders evolve upon tuning. This article reviews studies of the superconducting pairing symmetry, and the tuning of SC and CDW in the $A$V$_3$Sb$_5$ compounds. Various experimental techniques consistently find that CsV$_3$Sb$_5$ exhibits nodeless SC, which remains robust regardless whether the CDW is present. Under hydrostatic pressure, SC in $A$V$_3$Sb$_5$ becomes enhanced as the CDW is gradually suppressed, revealing a competition between the two orders. In CsV$_3$Sb$_5$, a new CDW state emerges under pressure that competes more strongly with SC relative to the CDW at ambient pressure, and results in two superconducting domes that coexist with CDW. After the CDW in $A$V$_3$Sb$_5$ is fully suppressed with hydrostatic pressure, a further increase in pressure leads to a nonmonotonic evolution of the superconducting transition temperature driven by lattice modulations. Thickness is shown to be a powerful tuning parameter in $A$V$_3$Sb$_5$ thin flakes, revealing the evolution of CDW and SC upon dimensional reduction, and can be combined with hydrostatic pressure to shed light on the interplay between SC and CDW. Based on results reviewed in this article, we discuss outstanding issues to be addressed in the $A$V$_3$Sb$_5$ systems.
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- 2024
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29. PriorMapNet: Enhancing Online Vectorized HD Map Construction with Priors
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Wang, Rongxuan, Lu, Xin, Liu, Xiaoyang, Zou, Xiaoyi, Cao, Tongyi, and Li, Ying
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Online vectorized High-Definition (HD) map construction is crucial for subsequent prediction and planning tasks in autonomous driving. Following MapTR paradigm, recent works have made noteworthy achievements. However, reference points are randomly initialized in mainstream methods, leading to unstable matching between predictions and ground truth. To address this issue, we introduce PriorMapNet to enhance online vectorized HD map construction with priors. We propose the PPS-Decoder, which provides reference points with position and structure priors. Fitted from the map elements in the dataset, prior reference points lower the learning difficulty and achieve stable matching. Furthermore, we propose the PF-Encoder to enhance the image-to-BEV transformation with BEV feature priors. Besides, we propose the DMD cross-attention, which decouples cross-attention along multi-scale and multi-sample respectively to achieve efficiency. Our proposed PriorMapNet achieves state-of-the-art performance in the online vectorized HD map construction task on nuScenes and Argoverse2 datasets. The code will be released publicly soon.
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- 2024
30. Intermittent Semi-working Mask: A New Masking Paradigm for LLMs
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Lu, Mingcong, Zhu, Jiangcai, Hao, Wang, Li, Zheng, Zhang, Shusheng, Shao, Kailai, Chen, Chao, Li, Nan, Wang, Feng, and Lu, Xin
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Multi-turn dialogues are a key interaction method between humans and Large Language Models (LLMs), as conversations extend over multiple rounds, keeping LLMs' high generation quality and low latency is a challenge. Mainstream LLMs can be grouped into two categories based on masking strategy: causal LLM and prefix LLM. Several works have demonstrated that prefix LLMs tend to outperform causal ones in scenarios that heavily depend on historical context such as multi-turn dialogues or in-context learning, thanks to their bidirectional attention on prefix sequences. However, prefix LLMs have an inherent inefficient training problem in multi-turn dialogue datasets. In addition, the attention mechanism of prefix LLM makes it unable to reuse Key-Value Cache (KV Cache) across dialogue rounds to reduce generation latency. In this paper, we propose a novel masking scheme called Intermittent Semi-working Mask (ISM) to address these problems. Specifically, we apply alternate bidirectional and unidirectional attention on queries and answers in the dialogue history. In this way, ISM is able to maintain the high quality of prefix LLM and low generation latency of causal LLM, simultaneously. Extensive experiments illustrate that our ISM achieves significant performance.
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- 2024
31. Enhancing octree-based context models for point cloud geometry compression with attention-based child node number prediction
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Sun, Chang, Yuan, Hui, Mao, Xiaolong, Lu, Xin, and Hamzaoui, Raouf
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Multimedia - Abstract
In point cloud geometry compression, most octreebased context models use the cross-entropy between the onehot encoding of node occupancy and the probability distribution predicted by the context model as the loss. This approach converts the problem of predicting the number (a regression problem) and the position (a classification problem) of occupied child nodes into a 255-dimensional classification problem. As a result, it fails to accurately measure the difference between the one-hot encoding and the predicted probability distribution. We first analyze why the cross-entropy loss function fails to accurately measure the difference between the one-hot encoding and the predicted probability distribution. Then, we propose an attention-based child node number prediction (ACNP) module to enhance the context models. The proposed module can predict the number of occupied child nodes and map it into an 8- dimensional vector to assist the context model in predicting the probability distribution of the occupancy of the current node for efficient entropy coding. Experimental results demonstrate that the proposed module enhances the coding efficiency of octree-based context models., Comment: 2 figures and 2 tables
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- 2024
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32. Enhancing context models for point cloud geometry compression with context feature residuals and multi-loss
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Sun, Chang, Yuan, Hui, Li, Shuai, Lu, Xin, and Hamzaoui, Raouf
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Multimedia - Abstract
In point cloud geometry compression, context models usually use the one-hot encoding of node occupancy as the label, and the cross-entropy between the one-hot encoding and the probability distribution predicted by the context model as the loss function. However, this approach has two main weaknesses. First, the differences between contexts of different nodes are not significant, making it difficult for the context model to accurately predict the probability distribution of node occupancy. Second, as the one-hot encoding is not the actual probability distribution of node occupancy, the cross-entropy loss function is inaccurate. To address these problems, we propose a general structure that can enhance existing context models. We introduce the context feature residuals into the context model to amplify the differences between contexts. We also add a multi-layer perception branch, that uses the mean squared error between its output and node occupancy as a loss function to provide accurate gradients in backpropagation. We validate our method by showing that it can improve the performance of an octree-based model (OctAttention) and a voxel-based model (VoxelDNN) on the object point cloud datasets MPEG 8i and MVUB, as well as the LiDAR point cloud dataset SemanticKITTI., Comment: 11 pages, 8 figures
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- 2024
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33. PCAC-GAN: A Sparse-Tensor-Based Generative Adversarial Network for 3D Point Cloud Attribute Compression
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Mao, Xiaolong, Yuan, Hui, Lu, Xin, Hamzaoui, Raouf, and Gao, Wei
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,94J20 ,I.4.2 - Abstract
Learning-based methods have proven successful in compressing geometric information for point clouds. For attribute compression, however, they still lag behind non-learning-based methods such as the MPEG G-PCC standard. To bridge this gap, we propose a novel deep learning-based point cloud attribute compression method that uses a generative adversarial network (GAN) with sparse convolution layers. Our method also includes a module that adaptively selects the resolution of the voxels used to voxelize the input point cloud. Sparse vectors are used to represent the voxelized point cloud, and sparse convolutions process the sparse tensors, ensuring computational efficiency. To the best of our knowledge, this is the first application of GANs to compress point cloud attributes. Our experimental results show that our method outperforms existing learning-based techniques and rivals the latest G-PCC test model (TMC13v23) in terms of visual quality., Comment: 14 pages, 5 figures, Accepted by Computational Visual Media
- Published
- 2024
34. SoP: Unlock the Power of Social Facilitation for Automatic Jailbreak Attack
- Author
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Yang, Yan, Xiao, Zeguan, Lu, Xin, Wang, Hongru, Huang, Hailiang, Chen, Guanhua, and Chen, Yun
- Subjects
Computer Science - Cryptography and Security ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
The widespread applications of large language models (LLMs) have brought about concerns regarding their potential misuse. Although aligned with human preference data before release, LLMs remain vulnerable to various malicious attacks. In this paper, we adopt a red-teaming strategy to enhance LLM safety and introduce SoP, a simple yet effective framework to design jailbreak prompts automatically. Inspired by the social facilitation concept, SoP generates and optimizes multiple jailbreak characters to bypass the guardrails of the target LLM. Different from previous work which relies on proprietary LLMs or seed jailbreak templates crafted by human expertise, SoP can generate and optimize the jailbreak prompt in a cold-start scenario using open-sourced LLMs without any seed jailbreak templates. Experimental results show that SoP achieves attack success rates of 88% and 60% in bypassing the safety alignment of GPT-3.5-1106 and GPT-4, respectively. Furthermore, we extensively evaluate the transferability of the generated templates across different LLMs and held-out malicious requests, while also exploring defense strategies against the jailbreak attack designed by SoP. Code is available at https://github.com/Yang-Yan-Yang-Yan/SoP.
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- 2024
35. TraceNet: Segment one thing efficiently
- Author
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Wu, Mingyuan, Liu, Zichuan, Zheng, Haozhen, Guo, Hongpeng, Chen, Bo, Lu, Xin, and Nahrstedt, Klara
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Efficient single instance segmentation is essential for unlocking features in the mobile imaging applications, such as capture or editing. Existing on-the-fly mobile imaging applications scope the segmentation task to portraits or the salient subject due to the computational constraints. Instance segmentation, despite its recent developments towards efficient networks, is still heavy due to the cost of computation on the entire image to identify all instances. To address this, we propose and formulate a one tap driven single instance segmentation task that segments a single instance selected by a user via a positive tap. This task, in contrast to the broader task of segmenting anything as suggested in the Segment Anything Model \cite{sam}, focuses on efficient segmentation of a single instance specified by the user. To solve this problem, we present TraceNet, which explicitly locates the selected instance by way of receptive field tracing. TraceNet identifies image regions that are related to the user tap and heavy computations are only performed on selected regions of the image. Therefore overall computation cost and memory consumption are reduced during inference. We evaluate the performance of TraceNet on instance IoU average over taps and the proportion of the region that a user tap can fall into for a high-quality single-instance mask. Experimental results on MS-COCO and LVIS demonstrate the effectiveness and efficiency of the proposed approach. TraceNet can jointly achieve the efficiency and interactivity, filling in the gap between needs for efficient mobile inference and recent research trend towards multimodal and interactive segmentation models.
- Published
- 2024
36. Non-autoregressive Personalized Bundle Generation
- Author
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Yang, Wenchuan, Yang, Cheng, Li, Jichao, Tan, Yuejin, Lu, Xin, and Shi, Chuan
- Subjects
Computer Science - Machine Learning ,Computer Science - Information Retrieval - Abstract
The personalized bundle generation problem, which aims to create a preferred bundle for user from numerous candidate items, receives increasing attention in recommendation. However, existing works ignore the order-invariant nature of the bundle and adopt sequential modeling methods as the solution, which might introduce inductive bias and cause a large latency in prediction. To address this problem, we propose to perform the bundle generation via non-autoregressive mechanism and design a novel encoder-decoder framework named BundleNAT, which can effectively output the targeted bundle in one-shot without relying on any inherent order. In detail, instead of learning sequential dependency, we propose to adopt pre-training techniques and graph neural network to fully embed user-based preference and item-based compatibility information, and use a self-attention based encoder to further extract global dependency pattern. We then design a permutation-equivariant decoding architecture that is able to directly output the desired bundle in a one-shot manner. Experiments on three real-world datasets from Youshu and Netease show the proposed BundleNAT significantly outperforms the current state-of-the-art methods in average by up to 35.92%, 10.97% and 23.67% absolute improvements in Precision, Precision+, and Recall, respectively., Comment: Submitted to Information Processing & Management
- Published
- 2024
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37. IGF-1 via PI3K/Akt/S6K signaling pathway protects DRG neurons with high glucose-induced toxicity
- Author
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Liu Chunhong, Liu Siyan, Wang Sheng, Sun Yi, Lu Xin, Li Hao, and Li Guibao
- Subjects
high glucose ,neurotoxicity ,dorsal root ganglion ,insulin-like growth factor-1 ,activating transcription factor 3 ,Biology (General) ,QH301-705.5 - Abstract
Hyperglycemia-induced toxicity of neurons contributes to the pathogenesis and progression of diabetic neuropathy (DNP). High concentration glucose triggered reactive oxygen species (ROS) overproduction and induced cell apoptosis of neurons from dorsal root ganglion (DRG) in vitro. Currently, there is no effective therapeutic method to retard this devastating complication or neurotoxicity induced by high glucose. Insulin-like growth factor-1 (IGF-1) has multi-neurotrophic actions which need to be explored regarding its actions and mechanisms on relieving high glucose induced neurotoxicity. Herein, high concentration glucose was exposed to the DRG neurons in vitro. The effects of IGF-1 on relieving high glucose-induced neurotoxicity were evaluated. We illustrated that IGF-1 enhanced regeneration of neurites sent from DRG neuronal cell bodies and increased neuronal viability which inhibited by high glucose challenge. IGF-1 alleviated neuronal apoptosis caused by high glucose exposure. IGF-1 also suppressed the intracellular ROS overproduction and ATF3 expression upregulation which was induced by high glucose insult. The anti-neurotoxic effects of IGF-1 might be through restoration of prosurvival PI3K/Akt/S6K signaling. These data shed some light on the treatment of intractable DNP and suggested that IGF-1 might be a potential effective agent on relieving high glucose induced neurotoxicity.
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- 2019
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38. Mechanism of D-bifunctional Protein Promoting Formation of Hepatocellular Carcinoma in Rat via STAT3
- Author
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LU Xin, KONG Lingyu, JIA Lei, and JIANG Lingling
- Subjects
dbp ,stat3 ,hepatocellular carcinoma ,cyclind1 ,pcna ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objective To investigate the expression of D-bifunctional protein (DBP) in hepatocarcinoma tissues of rat and its correlation with signal transducer and activator of transcription 3(STAT3). Methods Rat model of hepatocellular carcinoma(HCC) was induced by intraperitoneal injection of diethylnitrosamine(DEN). HE staining and serum biochemical indicators were used to detect liver pathological severity in HCC rats. Western blot, immunohistochemistry and qRT-PCR were used to detect the expression of DBP, PCNA, cyclinD1, p-STAT3, p-Akt, p-MEK and p-ERK. Results DEN induced severe liver deterioration in HCC rats. The expression of DBP in liver tissues of HCC rats was higher than that in normal rat liver. The mRNA expression of PCNA and cyclin D1 in HCC group were significantly higher than those in normal control(NC) group, and the expression of DBP was positively correlated with PCNA and cyclin D1 expression. The over-expression and knockdown of DBP increased and decreased the number of cells and the expression of PCNA, cyclin D1 protein in HepG2 cells, respectively. The expression of p-STAT3 was significantly increased in HCC group, and positively correlated with DBP expression. The protein levels of p-Akt, p-MEK and p-ERK were also significantly enhanced compared with the NC group. Conclusion Highly-expressed DBP plays a catalytic role in the development of rat liver cancer.
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- 2019
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39. Even- and Odd-denominator Fractional Quantum Anomalous Hall Effect in Graphene Moire Superlattices
- Author
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Xie, Jian, Huo, Zihao, Lu, Xin, Feng, Zuo, Zhang, Zaizhe, Wang, Wenxuan, Yang, Qiu, Watanabe, Kenji, Taniguchi, Takashi, Liu, Kaihui, Song, Zhida, Xie, X. C., Liu, Jianpeng, and Lu, Xiaobo
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Strongly Correlated Electrons - Abstract
Fractional quantum anomalous hall effect (FQAHE), a transport effect with fractionally quantized Hall plateau emerging under zero magnetic field, provides a radically new opportunity to engineer topological quantum electronics. By construction of topological flat band with moire engineering, intrinsic FQAHE has been observed in twisted MoTe2 system and rhombohedral pentalayer graphene/hBN moire superlattices with anomalous Hall resistivity quantization number C <= 2/3 including the gapless composite Fermi-liquid state with C = 1/2. Here we experimentally demonstrate a new system of rhombohedral hexalayer graphene (RHG)/hBN moire superlattices showing both fractional and integer quantum anomalous Hall effects when the lowest flat Chern band is fractionally and fully filled at zero magnetic field. The zero-field Hall resistance Rho_xy = h/Ce2 is quantized to values corresponding to C = 3/5, 2/3, 5/7, 3/4, 7/9 and 1 at moire filling factors v = 3/5, 2/3, 5/7, 3/4, 7/9 and 1, respectively. Particularly, the C = 3/4 FQAHE state at v = 3/4 moire filling featuring a minimum of longitudinal resistance Rho_xx and fractionally quantized Hall resistance Rho_xy = 4h/3e2, is observed for the first time under zero magnetic field. Such a state may be similar to the C = 3/4 fractional quantum hall (FQHE) state recently observed at high magnetic fields9,10 and possibly host fractional charge excitations obeying non-Abelian statistics. By tuning the electrical and magnetic fields at 0 < v < 1, we have observed a sign reversal of the Hall resistivity for v = 2/3 state, indicating a transition from quasi-electron-like excitations to quasi-hole ones. Our experiment has established RHG/hBN moire superlattices a promising platform to explore quasi-particles with fractional charge excitations and non-Abelian anyons at zero magnetic field.
- Published
- 2024
40. Albanese fibrations of surfaces with low slope
- Author
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Ling, Songbo and Lu, Xin
- Subjects
Mathematics - Algebraic Geometry - Abstract
Let $S$ be a minimal irregular surface of general type, whose Albanese map induces a fibration $f:\,S \to C$ of genus $g$.We prove a linear upper bound on the genus $g$ if $K_S^2\leq 4\chi(\mathcal{O}_S)$. Examples are constructed showing that the above linear upper bound is sharp. We also give a characterization of the Albanese fibrations reaching the above upper bound when $\chi(\mathcal{O}_S)\geq 5$.On the other hand, we will construct a sequence of surfaces $S_n$ of general type with $K_{S_n}^2/\chi(\mathcal{O}_{S_n})>4$ and with an Albanese fibration $f_n$, such that the genus $g_n$ of a general fiber of $f_n$ increases quadratically with $\chi(\mathcal{O}_{S_n})$,and that $K_{S_n}^2/\chi(\mathcal{O}_{S_n})$ can be arbitrarily close to $4$., Comment: Add a characterization of the Albanese fibrations reaching the above upper bound. Comments are welcome!
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- 2024
41. Modeling Supply Chain Interaction and Disruption: Insights from Real-world Data and Complex Adaptive System
- Author
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Feng, Jiawei, Cai, Mengsi, Dai, Fangze, Bu, Tianci, Zhang, Xiaoyu, Zheng, Huijun, and Lu, Xin
- Subjects
Computer Science - Social and Information Networks - Abstract
In the rapidly evolving automotive industry, Systems-on-Chips (SoCs) are playing an increasingly crucial role in enhancing vehicle intelligence, connectivity, and safety features. For enterprises whose business encompasses automotive SoCs, the sustained and stable provision and receipt of SoC relevant goods or services are essential. Considering the imperative for a resilient and adaptable supply network, enterprises are concentrating their efforts on formulating strategies to address risks stemming from supply chain disruptions caused by technological obsolescence, natural disasters, and geopolitical tensions. This study presents an open supply knowledge extraction and complement approach and build a supply chain network of automotive SoC enterprises in China, which incorporates cross-domain named entity recognition under limited information, fuzzy matching of firm entities, and supply relation inferring based on knowledge graph. Subsequently, we exhibit the degree and registered capital distribution across firms, and analyze the correlations between centrality metrics in the supply chain network. Finally, based on recovery capacity and risk transfer, two interaction disruption models (IDMs) are developed to elucidate the adaptive behaviors and effect of network disruptions under various business and attack strategies. This research not only aids in exploring the complexities of Chinese automotive SoC supply chain but also enriches our understanding of the dynamics of firm behavior in this crucial industry sector., Comment: arXiv admin note: text overlap with arXiv:2304.10428 by other authors
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- 2024
42. QuakeBERT: Accurate Classification of Social Media Texts for Rapid Earthquake Impact Assessment
- Author
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Han, Jin, Zheng, Zhe, Lu, Xin-Zheng, Chen, Ke-Yin, and Lin, Jia-Rui
- Subjects
Computer Science - Computation and Language ,Computer Science - Machine Learning ,Computer Science - Social and Information Networks - Abstract
Social media aids disaster response but suffers from noise, hindering accurate impact assessment and decision making for resilient cities, which few studies considered. To address the problem, this study proposes the first domain-specific LLM model and an integrated method for rapid earthquake impact assessment. First, a few categories are introduced to classify and filter microblogs considering their relationship to the physical and social impacts of earthquakes, and a dataset comprising 7282 earthquake-related microblogs from twenty earthquakes in different locations is developed as well. Then, with a systematic analysis of various influential factors, QuakeBERT, a domain-specific large language model (LLM), is developed and fine-tuned for accurate classification and filtering of microblogs. Meanwhile, an integrated method integrating public opinion trend analysis, sentiment analysis, and keyword-based physical impact quantification is introduced to assess both the physical and social impacts of earthquakes based on social media texts. Experiments show that data diversity and data volume dominate the performance of QuakeBERT and increase the macro average F1 score by 27%, while the best classification model QuakeBERT outperforms the CNN- or RNN-based models by improving the macro average F1 score from 60.87% to 84.33%. Finally, the proposed approach is applied to assess two earthquakes with the same magnitude and focal depth. Results show that the proposed approach can effectively enhance the impact assessment process by accurate detection of noisy microblogs, which enables effective post-disaster emergency responses to create more resilient cities.
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- 2024
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43. Slopes of fibrations with trivial vertical fundamental groups
- Author
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Liu, Xiao-Lei and Lu, Xin
- Subjects
Mathematics - Algebraic Geometry - Abstract
Kodaira fibrations have non-trivial vertical fundamental groups and their slopes are all $12$. In this paper, we show that $12$ is indeed the sharp upper bound for the slopes of fibrations with trivial vertical fundamental groups. Precisely, for each $g\geq3$ we prove the existence of fibrations of genus $g$ with trivial vertical fundamental groups whose slopes can be arbitrarily close to $12$. This gives a relative analogy of Roulleau-Urz\'ua's work on the slopes of surfaces of general type with trivial fundamental groups., Comment: Any comment is warmly welcome
- Published
- 2024
44. Network Structure Governs Drosophila Brain Functionality
- Author
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Zhang, Xiaoyu, Yang, Pengcheng, Feng, Jiawei, Luo, Qiang, Lin, Wei, and Lu, Xin
- Subjects
Quantitative Biology - Neurons and Cognition ,Computer Science - Social and Information Networks - Abstract
How intelligence emerges from living beings has been a fundamental question in neuroscience. However, it remains largely unanswered due to the complex neuronal dynamics and intricate connections between neurons in real neural systems. To address this challenge, we leveraged the largest available adult Drosophila connectome data set, and constructed a comprehensive computational framework based on simplified neuronal activation mechanisms to simulate the observed activation behavior within the connectome. The results revealed that even with rudimentary neuronal activation mechanisms, models grounded in real neural network structures can generate activation patterns strikingly similar to those observed in the actual brain. A significant discovery was the consistency of activation patterns across various neuronal dynamic models. This consistency, achieved with the same network structure, underscores the pivotal role of network topology in neural information processing. These results challenge the prevailing view that solely relies on neuron count or complex individual neuron dynamics. Further analysis demonstrated a near-complete separation of the visual and olfactory systems at the network level. Moreover, we found that the network distance, rather than spatial distance, is the primary determinant of activation patterns. Additionally, our experiments revealed that a reconnect rate of at least 0.1% was sufficient to disrupt the previously observed activation patterns. We also observed synergistic effects between the brain hemispheres: Even with unilateral input stimuli, visual-related neurons in both hemispheres were activated, highlighting the importance of interhemispheric communication. These findings emphasize the crucial role of network structure in neural activation and offer novel insights into the fundamental principles governing brain functionality.
- Published
- 2024
45. A Dual-domain Regularization Method for Ring Artifact Removal of X-ray CT
- Author
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Zhu, Hongyang, Lu, Xin, Qin, Yanwei, Yu, Xinran, Sun, Tianjiao, and Zhao, Yunsong
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Ring artifacts in computed tomography images, arising from the undesirable responses of detector units, significantly degrade image quality and diagnostic reliability. To address this challenge, we propose a dual-domain regularization model to effectively remove ring artifacts, while maintaining the integrity of the original CT image. The proposed model corrects the vertical stripe artifacts on the sinogram by innovatively updating the response inconsistency compensation coefficients of detector units, which is achieved by employing the group sparse constraint and the projection-view direction sparse constraint on the stripe artifacts. Simultaneously, we apply the sparse constraint on the reconstructed image to further rectified ring artifacts in the image domain. The key advantage of the proposed method lies in considering the relationship between the response inconsistency compensation coefficients of the detector units and the projection views, which enables a more accurate correction of the response of the detector units. An alternating minimization method is designed to solve the model. Comparative experiments on real photon counting detector data demonstrate that the proposed method not only surpasses existing methods in removing ring artifacts but also excels in preserving structural details and image fidelity.
- Published
- 2024
46. Non-existence of Shimura curves of Mumford type generically in the non-hyperelliptic locus
- Author
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Lu, Xin, Tan, Shengli, and Zuo, Kang
- Subjects
Mathematics - Algebraic Geometry ,14J10, 14E30 - Abstract
We show that there does not exist any Shimura curve with strictly maximal Higgs field generically in the Torelli locus of non-hyperelliptic curves of genus $g\geq 4$. In particular, Shimura curves of Mumford type are not generically in the Torelli locus of non-hyperelliptic curves of genus $g\geq 4$., Comment: Any comment is welcome
- Published
- 2024
47. How does Architecture Influence the Base Capabilities of Pre-trained Language Models? A Case Study Based on FFN-Wider and MoE Transformers
- Author
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Lu, Xin, Zhao, Yanyan, Qin, Bing, Huo, Liangyu, Yang, Qing, and Xu, Dongliang
- Subjects
Computer Science - Computation and Language - Abstract
Pre-trained language models have been proven to possess strong base capabilities, which not only excel in in-distribution language modeling but also show powerful abilities in out-of-distribution language modeling, transfer learning and few-shot learning. Unlike existing work focusing on the influence of scale on base capabilities, our work examines the influence of architecture on those. Specifically, our concern is: How does architecture influence the base capabilities of pre-trained language models? In this work, we attempt to explain and reverse the decline in base capabilities caused by the architecture of FFN-Wider Transformers, seeking to provide some insights. Through analysis, we found the contribution ratio of Multi-Head Attention (a combination function) to pre-trained language modeling is a key factor affecting base capabilities. FFN-Wider Transformers reduce the contribution ratio of this combination function, leading to a decline in base capabilities. We confirmed this by experiments and proposed Combination Enhanced Architecture (CEA) to address the decline in base capabilities of such models. Significantly, we extended our explanation and CEA to Mixture of Experts (MoE) Transformers. We successfully achieved significant improvements in base capabilities on a 14B parameter MoE model, demonstrating the practical application value of our work. This also indicates that our analysis has a certain guiding significance for architecture analysis, architecture improvement and architecture design., Comment: Accepted by NeurIPS 2024
- Published
- 2024
48. Vanilla Transformers are Transfer Capability Teachers
- Author
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Lu, Xin, Zhao, Yanyan, and Qin, Bing
- Subjects
Computer Science - Computation and Language - Abstract
Recently, Mixture of Experts (MoE) Transformers have garnered increasing attention due to their advantages in model capacity and computational efficiency. However, studies have indicated that MoE Transformers underperform vanilla Transformers in many downstream tasks, significantly diminishing the practical value of MoE models. To explain this issue, we propose that the pre-training performance and transfer capability of a model are joint determinants of its downstream task performance. MoE models, in comparison to vanilla models, have poorer transfer capability, leading to their subpar performance in downstream tasks. To address this issue, we introduce the concept of transfer capability distillation, positing that although vanilla models have weaker performance, they are effective teachers of transfer capability. The MoE models guided by vanilla models can achieve both strong pre-training performance and transfer capability, ultimately enhancing their performance in downstream tasks. We design a specific distillation method and conduct experiments on the BERT architecture. Experimental results show a significant improvement in downstream performance of MoE models, and many further evidences also strongly support the concept of transfer capability distillation. Finally, we attempt to interpret transfer capability distillation and provide some insights from the perspective of model feature.
- Published
- 2024
49. Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome
- Author
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Xu, Haiqi, Kong, Linzhen, Cheng, Jingfei, Al Moussawi, Khatoun, Chen, Xiufei, Iqbal, Aleema, Wing, Peter A. C., Harris, James M., Tsukuda, Senko, Embarc-Buh, Azman, Wei, Guifeng, Castello, Alfredo, Kriaucionis, Skirmantas, McKeating, Jane A., Lu, Xin, and Song, Chun-Xiao
- Published
- 2024
- Full Text
- View/download PDF
50. Validation of the 2018 (New) ENMC Classification Criteria for Dermatomyositis in Chinese Patients with Idiopathic Inflammatory Myopathies
- Author
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Zhang, Puli, Sun, Chao, Peng, Qinglin, Jiang, Wei, Tian, Xiaolan, Li, Ying, Cao, Zhen, Wang, Guochun, Qiao, Wei, and Lu, Xin
- Published
- 2024
- Full Text
- View/download PDF
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