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Scholars in several fields share a desire to better understand the inter-temporal dimensions of policy-making. While several studies analysed individuals' preferences regarding policies whose benefits unfold in the future, little is known about policy-makers' own perceptions of inter-temporal trade-offs in politics. Using an original survey of municipal politicians in Sweden, we demonstrate that factors found important in macro-level research on future-oriented policy-making also matter for politicians' micro-level perceptions. Politicians who perceive the policy-making process as consensus-oriented, characterised by corporatist concertation and by a low risk of policy reversal, and those who feel confident about (re-)election into government, are less likely to perceive a trade-off between policies that help them win elections and policies that benefit society in the long term, and less likely to view politics as short-term biased. Trade-off perceptions are, furthermore, related to previously overlooked variations in how politicians understand the inter-temporal profile of physical and social investment policies. Our findings have significant implications for comparative public policy research, by uncovering how politicians perceive inter-temporal trade-offs and shining new light on the micro-foundations of future-oriented policy-making. [ABSTRACT FROM AUTHOR]

Patients with refractory temporomandibular dysfunction (TMD) despite conservative therapies often require surgical intervention. Although techniques such as arthrocentesis or arthroscopy have been established for years, there remains a dearth of evidence regarding the long-term efficacy of these interventions. This preliminary prospective study aims to elucidate the outcomes of arthroscopic treatment conducted over five years ago in patients with temporomandibular dysfunction. A study involving 31 patients with temporomandibular dysfunction who underwent level II arthroscopic surgery prior to 2019 is presented. The principal objective parameter for joint function was mouth opening, while the primary subjective parameters included pain, which was measured using the visual analogue scale (VAS), and quality of life, assessed using the OHIP-14sp questionnaire. Objective parameters were assessed preoperatively at one year and five years postoperatively, while quality of life was evaluated both preoperatively and five years after the procedure. Subsequently, the long-term status of patients was analysed, including surgical outcomes and the necessity for supplementary techniques such as second arthroscopy or open surgery. The quality-of-life scores significantly improved (p < 0.001) after five years of follow up when compared with preoperative assessments. Pain levels exhibited a statistically significant decrease over the follow-up period (p < 0.001). Significant differences were observed between preoperative and both 12-months' and five-years' follow up (both p < 0.001) but not between the 12-month and five-year marks (p = 0.899). Similar trends were noted for maximum mouth opening, with differences between pre-surgery and both 12-months' and five-years' follow up (p = 0.049 and p = 0.005, respectively) but not between the 12-month and five-year assessments (p = 0.482). Mouth opening at 12 months (p = 0.003) and five years (p = 0.032), as well as OHIP results at five years (p = 0.003), demonstrated statistically significant differences between groups according to the final status. In all cases, poorer clinical outcomes post-surgery (requiring a second arthroscopy or meniscectomy) correlated with decreased mouth opening and worse OHIP results. Arthroscopy emerges as an effective technique in the long-term treatment of temporomandibular joint dysfunction, as parameters such as pain and maximum mouth opening improve, and this improvement remains stable at the five-year follow up. [ABSTRACT FROM AUTHOR]

ABSTRACT Aim Materials and Methods Results Conclusion To evaluate long‐term survival and success of dental implants and evaluate indicators affecting the long‐term outcome.Implant survival, success and crestal bone loss (BL) over time were evaluated. For covariates at patient level, Kaplan–Meier estimates of implant survival were compared between groups with the log‐rank test. Observed mean bone loss (MBL) was plotted as a function of time. Cumulative frequencies of BL were plotted for different post‐op times. Uni‐ and multivariate analysis was performed. Simple linear mixed and multiple linear mixed models for BL at 1, 5 and 10 years were fitted.407 patients (221 women, 186 men; mean age 64.86 years (range 28–92, SD 10.11)), with 1482 implants, responded. Absolute implant survival was 94.74%; MBL was 0.81 mm (SD 1.58, range 0.00–17.00) after an average follow‐up of 10.66 years (range 10–14, SD 0.87). Implant survival was influenced on implant level by smoking, implant width and early bone loss (EBL) > 0.5 mm; on patient level by a history of periodontitis. Indicators influencing MBL after the 1st year were abutment height, type of surgery and implant width, while after 5 and 10 years of function were abutment height, EBL > 0.5 mm and smoking.Implant survival was significantly affected by a history of periodontitis on patient level and by smoking, implant width and EBL > 0.5 mm on implant level. Late bone loss was significantly affected by abutment height, EBL > 0.5 mm and smoking.Trial Registration: B670201524796 [ABSTRACT FROM AUTHOR]

In representative democracies, the absence of responsiveness by elected officials to the interests of the represented often generates problems of legitimacy, accountability and effectiveness. However, responsiveness also tends to narrow the time horizons of democratic decision-making and promote short-termism. This paper advances the notion that responsiveness to interests involving distant time horizons is possible by reconfiguring the franchise in a time-sensitive and future-oriented way. It is divided into two parts. The first pinpoints a few inconsistencies in the available proposals for making responsiveness and the long term compatible (e.g., promoting youth turnout, narrowing the franchise to robust epistemic fitness, establishing future-oriented institutions). The second advances the creation of temporal electoral circles operating alongside territorial electoral circles in order to prompt responsiveness to multitemporal interests. The conclusion asserts that this kind of franchise design is the best available option for introducing temporal aspects into the character of democratic representation. [ABSTRACT FROM AUTHOR]

ABSTRACT Background Materials and Methods Results Conclusion It has been suggested that 1–2 mm of bone width at the buccal and lingual aspect is required for a successful long‐term implant outcome. Low levels of evidence support this minimum threshold of bone width. This prospective study aimed at evaluating the outcome of implants placed in alveolar ridges with limited bucco‐oral dimensions.One‐hundred implants (dia. 3.5 mm) were placed in 28 patients with narrow alveolar ridge dimensions (<4.5 mm width) without augmentation procedures and conventionally loaded. Intra‐oral radiographs were taken at implant placement and abutment connection and at 1, 2, 3, 5 and 10 years of follow‐up. At the 10‐year follow‐up (21 patients; 75 implants), full‐mouth periodontal charting was performed, and the peri‐implant keratinized tissue width and attachment type were recorded. Two calibrated periodontists analysed the peri‐implant bone changes.After 10 years, all implants showed successful osseointegration and a cumulative survival rate of 100%. The implants were placed 0.85 mm ± 0.89 mm subcrestally. After 10 years, the marginal bone was located 1.59 ± 2.11 mm apical to the implant shoulder. Throughout this period of follow‐up, the mean annual marginal bone loss was 0.094 mm. Furthermore, 84% of implants in 72% of patients presented with bleeding on probing.After 10 years of functional loading, implants placed in alveolar ridges with limited bucco‐oral dimensions (≤4.5 mm) exhibited only minimum marginal bone loss. [ABSTRACT FROM AUTHOR]

Background: Despite improved visualization, the use of arthroscopic surgery to perform the Latarjet procedure has not decreased the rates of complications and glenohumeral osteoarthritis (OA) in the long term. Many of the reported complications are related to the use of screws for bone block fixation with freehand drilling. Purpose: To evaluate the long-term (at a minimum 10-year follow-up) clinical and radiological outcomes of the arthroscopic Bristow-Latarjet procedure using a posterior guided drilling technique and suture button for coracoid bone graft fixation. Study Design: Case series; Level of evidence, 4. Methods: Consecutive patients who underwent the arthroscopic Bristow-Latarjet procedure with suture button fixation between 2011 and 2013 were reviewed by 2 independent evaluators. Complications and revision surgery were recorded, and we evaluated patient-reported outcomes including subjective scores, recurrence of shoulder instability (dislocation or subluxation), range of motion limitations, and return to sports. Patients had radiographs taken at least 10 years after surgery to assess glenohumeral OA according to the Samilson-Prieto classification system and computed tomography scans to assess bone block positioning and healing. Results: A total of 65 consecutive patients (68 shoulders) with a mean follow-up of 135 months (range, 120-156 months) were included. The mean age at the time of surgery was 25 ± 8 years; 7 patients had previous failed Bankart repair. At follow-up, 94% (64/68) of the shoulders had no recurrence of instability. The 4 cases of instability recurrence were traumatic and occurred at 3 weeks (a fall), 4 months, 2 years, and 7 years after surgery. No hardware failures, coracoid fractures, or neurological complications were observed. Overall, 61 patients (94%) were still participating in sports, with 44 (68%) at the same or higher level. Range of motion showed nonsignificant restrictions in external rotation with the arm at the side (7° ± 9°) and with the arm at 90° of abduction (9° ± 10°) compared with the contralateral side. Additionally, 11 shoulders (16%) had some residual anterior apprehension on clinical examination. At last follow-up, 77% (47/61) of the shoulders had no OA development or progression. Previous failed Bankart repair was a risk factor for the development of OA. Patients with OA had significantly lower Subjective Shoulder Value scores (79% vs 91%, respectively; P =.01) and decreased external rotation with the arm at the side (40° vs 65°, respectively; P =.001) compared with patients with no or little OA. Conclusion: The arthroscopically guided Bristow-Latarjet procedure with suture button fixation is a safe and durable surgical treatment method for recurrent anterior shoulder instability, allowing a high rate of return to sports without significant motion restrictions and no or little OA in the long term. [ABSTRACT FROM AUTHOR]

To evaluate the long-term success rate of endoscopic third ventriculostomy (ETV) in the treatment of hydrocephalus due to aqueductal stenosis in the pediatric population. Between January 2007 and June 2023, a total of 82 children underwent ETV surgery for hydrocephalus and met the inclusion criteria for our study. The children's medical records were reviewed, and cases requiring additional surgery in the months and years following surgery for ventriculostomy failure were reviewed. The mean age was 5.35 years. Successful ETV was observed in 74 children with a successful ETV rate of 90%. The median follow-up was 6.75 years (2 months to 15.5 years). Eight children (10%) underwent additional surgery. In 7 cases, additional surgery was performed within 3 months, while in the remaining case; a delayed failure was noted (more than 3 years later). At 6 months and 3 years, the cumulative proportion of children with revision-free survival was 91%, declining slightly to 89% at 5 years. ETV is highly effective in treating hydrocephalus in pediatric patients with aqueductal stenosis, with a 91% success rate at 6 months and 3 years. Although the success rate drops slightly to 89% at 5 years, it still demonstrates durability. Late failures are usually characterized by symptoms of increased intracranial pressure. While patients with a confirmed successful ETV at 6 months may be considered for reduced follow-up frequency, it is critical to educate them about the symptoms of intracranial hypertension and the importance of seeking medical attention promptly if such symptoms occur. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the efficacy and safety of a low‐dose, long‐term rituximab regimen in the treatment of idiopathic CIDP. Methods: This study included 15 CIDP patients treated with rituximab. Patients were administered 600 mg of rituximab intravenously every 6 months. Baseline evaluation was conducted before the initiation of rituximab treatment and subsequent evaluations were conducted 6 months after each rituximab infusion at on‐site visits. Clinical improvement was objectively determined by improvement of scale score at least decrease ≥1 INCAT or mRS or increase ≥4 MRC or ≥8 cI‐RODS after each infusion compared to baseline evaluation. Results: Fifteen CIDP patients were included and 10 of them were typical CIDP and five were distal CIDP. Nine in 15 (60%) patients after first infusion and three in six (50%) patients after second infusion exhibited significant clinical improvement compared to baseline evaluation. Additionally, rituximab facilitated a reduction or cessation of other medications in 73% of patients at last visit. The safety profile was favorable, with no reported adverse events. Conclusion: Rituximab presents a promising therapeutic option for idiopathic CIDP, offering both efficacy and safety with a low‐dose, long‐term regimen. [ABSTRACT FROM AUTHOR]

Total hip arthroplasty implant choice profoundly affects survivorship, complications, and failure modes. This study evaluates the long-term (average 18 year) outcomes of ceramic-on-ceramic hip arthroplasty using uncemented shells and stems. Despite an impressive 20-year cumulative percent revision of 5.9%, the hydroxyapatite proximally coated femoral components evaluated in this study have seen declining use since 2003. A review of 349 consecutive total hip arthroplasties from 1999 to 2007 was matched to 272 cases with registry data. A survivorship analysis included 274 hips (Group A) after excluding patients lost to follow-up and navigated cases. Group B comprised 135 patients who had complete datasets spanning a minimum of 15 years. Kaplan-Meier analysis identified a 95.6% survivorship plateau at 16 to 24 years, with no significant impact from age, sex, component size, or original pathology. In Group B, EuroQol-5 Dimensions-5 Levels (EQ5D5L) scores indicated favorable outcomes in mobility, self-care, activities, pain/discomfort, and anxiety/depression, with an EQ5D visual analog score mean of 79.24. Functional scores, including the Harris Hip Score, Oxford Hip Score, and Forgotten Joint Score, showed positive outcomes. Radiologic assessments revealed no osteolysis or loose components, with a mean Engh score of 21.69. Dorr classification identified bone quality variations. Better Engh scores corresponded to higher levels of patient satisfaction. Age at surgery was correlated with better functional scores, while sex influenced various outcomes. This comprehensive study, spanning an average of 18.23 years, combined multiple patient-reported outcome measures with extensive clinical and radiologic follow-up. It reported a notably high survivorship rate for this implant combination but highlighted the declining use of the hydroxyapatite proximally coated femoral stem used in this study, potentially facing withdrawal risks in Australia. Therapeutic Level IV. [ABSTRACT FROM AUTHOR]

Objectives: Mindfulness-based interventions (MBIs) have been shown to be beneficial for young adults with adverse childhood experiences (ACE), but the temporal course of the therapeutic effects is still not well understood. This study aimed to investigate MBI-induced weekly changes and long-term effects in trait mindfulness and psychological symptoms. Method: This study analyzed longitudinal data from a mechanistic clinical trial in which young adults (aged 21–35) with ACE were randomized to an 8-week MBI or an active control condition of Stress Management Education (SME), with 21 and 19 completers, respectively. The Mindful Attention Awareness Scale (MAAS), Perceived Stress Scale (PSS), and Kellner's Symptom Questionnaire (KSQ) were administered before, after, and weekly during the 8-week interventions, and at 6-, 12-, and 18-months follow-up. Data analyses were conducted with linear mixed effects models, Granger causality, and dynamic structural equation modeling (DSEM). Results: Group by time interaction effects were observed with PSS, MAAS, KSQ-depression, KSQ-hostility, and KSQ-anxiety with small effect sizes. Only in the MBI group, increases of MAAS scores predicted reductions of PSS, KSQ-somatization, and KSQ-hostility scores. MAAS score reached significant increase at the end of MBI, and most MBI-induced symptom reduction lasted 12 months without refresher courses. Conclusions: MBI demonstrated unique effects of trait mindfulness improvement leading to psychological symptom reductions. At least 8 weeks of MBI program duration and refreshment at 12 months may be necessary for ACE survivors. Preregistration: This study is not preregistered. [ABSTRACT FROM AUTHOR]

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This research proposes a new adaptive binned Kernel Density Estimation (KDE) method to fit significant wave height data in order to more accurately calculate the sea state parameter distribution tails. The brief details of the proposed new methodology are to utilize the fast Fourier transform to perform the convolution of the data with the kernel to find the kernel density estimates on the bin nodes. The Crámer-von Mises test statistic for the proposed adaptive KDE distribution is calculated to be 0.0926 based on a measured wave data set. The Crámer-von Mises test statistic value for the fitted 3-parameter Weibull distribution based on the identical measured data set is 251.2463, indicating a much poorer fit to the empirical distribution function. The advantages of using a more reliable and accurate contour line derived using the proposed new method for long term reliability analysis of wave energy converters have been finally substantiated. [ABSTRACT FROM AUTHOR]

The implementation of nature-based solutions (NbS), including living shorelines, to mitigate estuarine habitat loss is increasing at a pace exceeding the evaluation of their long-term success. Constructed oyster reefs (CORs) made of shell, concrete, stone, and other materials are one living shoreline tactic that is widely utilized, yet few studies have been conducted to understand the development of CORs within the context of both physical and ecological parameters over longer time scales (4 + years). A COR-based living shoreline project at the Gandy’s Beach Preserve (GBP) in Delaware Bay, NJ, USA, had dual goals of coastal protection and habitat provisioning, which prompted the development of a goal-driven monitoring framework to track project objectives. Methods were developed to quantify the following multi-disciplinary metrics over 7 years: elevations of CORs, waves (height, period, and direction), shoreline elevations, change in extent of vegetation patches, oyster density and size, nekton richness and community composition, and horseshoe crab impingement. The CORs met most of their habitat provisioning objectives as they were colonized by a multi-generational population of shellfish and created habitat for nekton, while posing negligible hazards to horseshoe crabs. However, none of the coastal protection objectives was fully achieved including material stability, wave attenuation, and sediment elevation increase. Results highlight the value of longer-term monitoring to understand performance and the need to match the scale and type of NbS tactic(s) with both the scale of the landscape and the site-specific hydrodynamic conditions to meet project goals. [ABSTRACT FROM AUTHOR]

Abstract Background Patients with chronic pain usually regard pain as a stressful situation. The literature revealed that chronic pain is associated with social and cognitive dysfunction. Recently, the literature started to support using cognitive behavioral therapy to reduce the effect of chronic nonspecific low back pain. Objectives The study aimed to assess the effect of cognitive behavioral therapy versus core stabilization training in the treatment of subjects with non-specific chronic low back pain. Methods Ninety subjects were enrolled in the current study, with mean age (32.30 ± 4.38) and mean weight (72.27 ± 10.88). They were equally randomized into three equal groups A, B, and C using opaque envelopes and computer-generalized numbers. Group A received cognitive behavioral therapy plus traditional treatment, group B received a core stabilization training program plus traditional treatment, and group C received only traditional treatment. Visual Analog Scale, Fear Avoidance and Belief Questionnaire, and Oswestry Disability Index were used pre- and post-treatment to measure the outcomes in response to the treatment plans. Results Statistical analysis revealed that there was a significant decrease in the Visual Analog Scale, Fear Avoidance and Belief Questionnaire, and Oswestry Disability Index post-treatment compared with pre-treatment in group A (P

Abstract Background The time‐series data of the Normalized Difference Vegetation Index (NDVI) is a crucial indicator for global and regional vegetation monitoring. However, the current assessment of global and regional long‐term vegetation changes is subject to large uncertainties due to the lack of spatiotemporally continuous time‐series data sets. Methods In this study, a long time‐series monthly NDVI data set with a spatial resolution of 250 m from 1982 to 2020 was developed by combining Moderate Resolution Imaging Spectroradiometer (MODIS) and AVHRR (Advanced Very High‐Resolution Radiometer) time‐series NDVI products using the Random Forest (RF) downscaling model. Results Compared to the MODIS NDVI product, the fused product shows RMSE and mean absolute error ranging from 0 to 0.075 and from 0 to 0.05, respectively, with R2 values mostly above 0.7. Conclusions The long time‐series NDVI products generated in this study are reliable in terms of accuracy and have great potential for long‐term dynamic monitoring of terrestrial ecosystems on the Qinghai–Tibet Plateau.

A business model, defined as the underlying logic of a company, is not permanent over time. Instead, companies need to introduce innovations in the business model to be competitive in the market. This is even more critical for family firms which are continuously looking for a way to obtain sustainable growth, together with satisfactory performance. The objective of this research is to analyze the impact that business model innovation activities have in the short/long-term growth and performance of family firms. This study was obtained from panel data made up of 112 valid responses from family firms involved in business model innovation. A composite model approach has been used for data analysis. The significant components of BMI that lead to greater growth and performance are identified, the distinction between long-term and short-term effects of BMI on those outcomes is made, and BMI is proven as an authoritative source of competitive advantage and growth in family firms. Those aspects are valuable insights for researchers and managers with regards to which innovation propositions help sustain growth and performance over time.

Abstract Purpose High levels of physical activity have been documented in eating disorder patients. Our aim was to examine whether adolescent leisure-time physical activity is prospectively associated with eating disorders in adolescence and young adulthood. Methods Finnish twins born in 1983–1987 reported their physical activity frequency at ages 12, 14, and 17. A subsample of participants underwent structured, retrospective interviews for eating disorders at the mean age of 22.4 years. Associations between female twins’ physical activity and future eating disorders (571–683 twins/wave) were investigated with the Cox proportional hazards model. To illustrate the physical activity similarity of the co-twins in a twin pair, we used cross-tabulation of eating disorder–discordant twin pairs (13–24 pairs/wave). Results After adjusting for several covariates, we found no statistically significant longitudinal association between physical activity and eating disorders. This applied when all eating disorders were combined but also when assessed separately as restrictive and non-restrictive eating disorders. Co-twins’ physical activity in adolescence tended to be similar irrespective of their future eating disorder, supporting the results of the regression analysis. Conclusion We observed no evidence of adolescent physical activity frequency being prospectively associated with eating disorders in female twins. Further longitudinal studies with larger sample sizes and more detailed physical activity data are needed. Level of evidence: III, evidence obtained from cohort or case–control analytic studies.

Many series have compared voice quality after radiotherapy or surgery for cT1 glottic carcinoma. Different meta-analyses identify better results for radiotherapy while others do not identify any difference, some finally find a superiority of surgery. The purpose of this study was to compare the voice quality in the long term of patients who underwent transoral surgery versus exclusive irradiation for the treatment of cT1 glottic carcinoma. The VOQUAL study was a pilot comparative multicenter cross-sectional study. The primary endpoint was the Voice Handicap Index comparison between two groups (radiotherapy or surgery). The voice assessment also consisted in the heteroevaluation of voice quality by the Grade, Roughness, Breathness, Asthenia, and Strain rating scale reported by Hirano. The study included 41 adult patients with cT1 carcinoma of the vocal cord treated by cordectomy or exclusive radiation in two oncologic centers. The median Voice Handicap Index value was 20 [8; 32.5] in the surgery group and 10 [4; 18.5] in the radiotherapy group. There was no statistically significant difference between the median values and the various components F, P and E of the questionnaire (P = 0.1585). The median value of the numeric dysphonia Grade, Roughness, Breathness, Asthenia, and Strain scale was 2 [0; 5] in the surgery group and 2 [0.25; 3.75] in the radiotherapy group. There was no statistically significant difference between these values (P = 0.78). Our study did not show any significant difference on the primary endpoints of Voice Handicap Index and Grade, Roughness, Breathness, Asthenia, and Strain scores. III. Clinical trial registration: The VOQUAL study was registered on the ClinicalTrials.gov platform under the number NCT04447456 , in July 2020. [ABSTRACT FROM AUTHOR]

Routine patellar resurfacing during primary total knee arthroplasty (TKA) remains controversial. To our knowledge, there are no studies reporting the long-term performance of a cemented biconvex all-polyethylene inlay component implanted at the time of primary TKA. The purpose of this study was to examine the 15-year survivorship and long-term clinical outcomes of this biconvex inlay patella used at our institution. We retrospectively reviewed our prospectively collected institutional database and identified 2,530 patients who underwent cemented TKA with a single prosthetic design (from 1996 to 2007) where the patella was resurfaced using this cemented biconvex inlay patella. The mean age at surgery was 68 years (range, 29 to 93). The mean body mass index was 33.0 (range, 16.4 to 76.3), with 61.9% women. At the time of analysis, the mean time from surgery was 20.4 years (range, 15 to 26). We used Kaplan–Meier analysis to calculate survivorship at 15 years. We analyzed clinical outcomes using 3 patient-reported outcome measures collected prospectively. The 15-year survivorship with revision surgery for all causes as the end point was 97.1% (95% confidence interval 96.1 to 98.1%). The 15-year survivorship with revision surgery for a patella-related complication as the end point was 99.7% (95% confidence interval 99.4 to 1.0). At the final follow-up, patients showed significant improvement in scores for the Knee Society Clinical Rating System (P <.001), Western Ontario and McMaster University Osteoarthritis Index (P <.001), and Veterans Rand 12-Item Health Survey physical component (P <.001). Routine patellar resurfacing using a biconvex inlay patellar component has excellent survivorship and a low rate of complications at 15 years post-TKA. [ABSTRACT FROM AUTHOR]

Background: Patients with chronic pain usually regard pain as a stressful situation. The literature revealed that chronic pain is associated with social and cognitive dysfunction. Recently, the literature started to support using cognitive behavioral therapy to reduce the effect of chronic nonspecific low back pain. Objectives: The study aimed to assess the effect of cognitive behavioral therapy versus core stabilization training in the treatment of subjects with non-specific chronic low back pain. Methods: Ninety subjects were enrolled in the current study, with mean age (32.30 ± 4.38) and mean weight (72.27 ± 10.88). They were equally randomized into three equal groups A, B, and C using opaque envelopes and computer-generalized numbers. Group A received cognitive behavioral therapy plus traditional treatment, group B received a core stabilization training program plus traditional treatment, and group C received only traditional treatment. Visual Analog Scale, Fear Avoidance and Belief Questionnaire, and Oswestry Disability Index were used pre- and post-treatment to measure the outcomes in response to the treatment plans. Results: Statistical analysis revealed that there was a significant decrease in the Visual Analog Scale, Fear Avoidance and Belief Questionnaire, and Oswestry Disability Index post-treatment compared with pre-treatment in group A (P < 0.001), group B (P < 0.001), and group C (P < 0.001). Also, the results revealed that there was a significant decrease in the Visual Analog Scale, Fear Avoidance and Belief Questionnaire work/lifestyle, and Oswestry Disability Index of group A compared with group B (P < 0.05) and group C (P < 0.001) and a significant decrease in outcome measures in group B compared with group C (P < 0.05). Conclusion: The results of the current study support the involvement of cognitive therapy in the management of chronic pain as it guides the patient to be aware of the underlying mechanism of chronic pain and the management maneuvers to overcome such pain. Also, the results provide credit to cognitive behavioral therapy in terms of long-term relief of chronic pain. [ABSTRACT FROM AUTHOR]

Introduction: the selective IL-17 inhibitor secukinumab has demonstrated efficacy and safety in the treatment of moderate–severe psoriasis in recent years. Objective: evaluate effectiveness and drug survival (DS) of secukinumab in patients with psoriasis for up to 5 years. Methods: This is a retrospective study on a monocentric cohort of patients with psoriasis on secukinumab evaluating the achievement of PASI100, PASI90, and PASI ≤ 3 and DS analysis up to 260 weeks. DS multivariate analysis was carried out considering sex, age, age of onset of the disease, obesity, cardiovascular comorbidities, diabetes, involvement of difficult-to-treat sites, psoriatic arthritis, treatment-naïve status, and mean baseline PASI. Results: At baseline, we evaluated 255 patients on secukinumab. PASI100 was reached by 41.7% and 70.6% of patients at weeks 16 and 260, respectively. PASI90 showed a similar trend with 46.5% of patients achieving it at week 16 and 88.2% at week 260. Non-obese patients showed a faster response than patients with obesity in achieving PASI100, PASI90, and PASI ≤ 3, with significant differences at 28 weeks [55% vs. 40% (p = 0.033), 64% vs. 49% (p = 0.038), and 76% vs. 62% (p = 0.036), respectively]. The estimated DS for secukinumab was 84.3% at 12 and 48% at 60 months. Obesity and smoking habits were associated with a higher risk of discontinuation in multivariate models (HR 1.6 CI 1.05–2.45, p = 0.028; HR 1.48 CI 1.01–2.17, p = 0.043, respectively). Conclusions: Secukinumab showed effectiveness for up to 5 years of treatment, with a high DS and achievement of PASI100, PASI90, and PASI < 3 at these time points. Only obesity reduced the response and maintenance of DS. [ABSTRACT FROM AUTHOR]

Background While persistence of chronic symptoms following dengue infection has been documented in small prospective cohorts, population-based studies are limited. The post-acute risk of new-incident multi-systemic complications following dengue infection was contrasted against that following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a multi-ethnic adult Asian population. Methods National testing and healthcare claims that databases in Singapore were utilized to build a retrospective population-based adult cohort with laboratory-confirmed infection during overlapping waves of SARS-CoV-2 and dengue transmission (1 July 2021 to 31 October 2022). Risks of new-incident cardiovascular/neuropsychiatric/autoimmune complications 31–300 days of post-dengue infection, contrasted with SARS-CoV-2 infection, were estimated using Cox regression with overlap weights. Risks were reported in terms of adjusted hazard ratio (aHR) and excess burden per 1000 persons. Results 11 707 dengue-infected individuals and 1 248 326 contemporaneous coronavirus disease 2019 (COVID-19) cases were included; the majority had mild initial infection not requiring hospitalization. Amongst dengue-infected individuals, there was 21% [aHR = 1.21 (1.06–1.38)] increased risk of any sequelae, with 55% [aHR = 1.55 (1.27–1.89)] increased risk of cardiovascular sequelae. Specifically, increased risk of dysrhythmias [aHR = 1.79(1.35–2.37)], ischemic heart disease [aHR = 1.45(1.12–1.89)], other cardiac disorders [aHR = 2.21(1.54–3.16)] and thrombotic disorders [aHR = 2.55(1.50–4.35)] was noted. Elevated risk of individual neuropsychiatric sequelae, including cerebrovascular disorders [aHR = 1.49(1.09–2.13)], cognition/memory disorders [aHR = 2.13(1.55–2.93)], extrapyramidal/movement disorders [aHR = 1.98(1.33–2.94)] and anxiety disorders [aHR = 1.61(1.01–2.56)], was observed in dengue-infected individuals compared to COVID-19 cases. Elevated risks of post-acute sequelae in dengue survivors were observed when contrasted against COVID-19 survivors infected during Delta/Omicron predominance, as well as across vaccination strata. Conclusion Increased risk of post-acute cardiovascular/neuropsychiatric complications was observed in dengue survivors, when contrasted against COVID-19 survivors infected during Delta/Omicron predominance. Research in context Evidence before this study Post-acute sequelae following SARS-CoV-2 infection has been extensively reported; however, long-term sequelae may also occur after other acute infections, such as dengue. While chronic symptom persistence has been reported in small cohorts of dengue survivors, population-based cohort studies are lacking, given dengue's disproportionate burden in tropical low-and-middle-income countries (LMICs) where access to diagnostic testing and follow-up is limited. We searched PubMed for studies published until 1 March 2024, using search terms 'dengue', 'chronic', 'long term', "with search terms found in abstract, title or MESH headings. Current research on post-acute sequelae following dengue is limited to small prospectively recruited cohorts, impairing generalizability to the population at-large. We only found four population-based retrospective cohort studies from a single country, Taiwan, which examined long-term risk of a limited set of autoimmune and cognitive sequelae following dengue infection. Evidence for post-acute sequelae was mixed, particularly when milder non-hospitalized cases were included. There are no reports on the risk of post-acute sequelae across multiple organ systems following dengue infection, and no reports contrasting the risk of post-acute sequelae in dengue versus SARS-CoV-2 infection. Added value of this study National testing and healthcare claims that databases in Singapore were utilized to build a retrospective population-based adult cohort of laboratory-confirmed dengue and SARS-CoV-2 infections during overlapping waves of COVID-19/dengue transmission. Increased overall risk of any post-acute sequelae and individual cardiovascular/neurological sequelae in dengue-infected adults was observed up to 300 days postinfection, compared against COVID-19 cases infected during Delta/Omicron predominance. While other studies have compared the risk of post-acute sequelae across different respiratory viral infections, such as influenza and SARS-CoV-2, to the best of our knowledge no prior studies have contrasted the potential risks of post-acute sequelae following dengue with that arising after SARS-CoV-2 infection. Implication of all the available evidence Risk of chronic multi-systemic sequelae arising post-dengue infection was significantly elevated when contrasted against post-acute sequelae following COVID-19. Post-acute sequelae may increase the burden of disease attributable to dengue in tropical countries where seasonal outbreaks occur; this is increasingly relevant, given that climate change has broadened the list of countries at risk of dengue endemicity. [ABSTRACT FROM AUTHOR]

Background: Recent systematic reviews on the outcomes of sulcus-deepening trochleoplasty with adjuvant medial patellofemoral ligament (MPFL) reconstruction at a follow-up of 2 to 6 years have found that the procedure grants good clinical outcomes with low redislocation rates. However, there is a lack of evidence in the literature regarding mid- and long-term follow-ups. Purpose: To evaluate the radiographic and clinical outcomes of thick-flap sulcus-deepening trochleoplasty with MPFL reconstruction at a minimum follow-up of 10 years to assess the signs of patellofemoral arthritis, incidence of recurrent dislocation, and grade of patient satisfaction. Study Design: Case series; Level of evidence, 4. Methods: The authors evaluated a retrospective series of 43 patients (48 knees) who underwent sulcus-deepening trochleoplasty between 2003 and 2013. All patients underwent thick-flap sulcus-deepening trochleoplasty with additional MPFL reconstruction. All patients were assessed at a minimum follow-up of 10 years by an independent clinician who noted any patellar redislocation or reoperations in the operated knee and collected the International Knee Documentation Committee (IKDC), Kujala, and satisfaction scores. Furthermore, a radiographic examination was performed to assess patellar height using the Caton-Deschamps index and patellofemoral arthritis using the Iwano classification. Results: At a mean follow-up of 14.8 ± 2.1 years (range, 10-20 years), 4 patients (4 knees) were lost to follow-up (8.3%). The satisfaction, Kujala, and IKDC scores were 8.2 ± 1.6, 77.5 ± 14.4, and 65.7 ± 13.5, respectively. Only 1 patient reported a traumatic patellar dislocation (2%). Radiographs at the final follow-up were available for 34 knees, which revealed Iwano grade 1 in 14 knees (41%), Iwano grade 2 in 7 knees (21%), and no patellofemoral arthritis in 13 knees (38%). Conclusion: Sulcus-deepening trochleoplasty with MPFL reconstruction provides satisfactory results and prevents patellar redislocations with no or minimal patellofemoral arthritis. [ABSTRACT FROM AUTHOR]

Background: Acute basilar artery occlusion is a life-threatening medical emergency with a highly elevated mortality rate when left untreated. Little is known about symptoms and clinical progression of chronic occlusions. The aim of this study was to systematically analyze the clinical presentation of patients with chronic basilar artery occlusion (CBAO). Methods: Monocentric retrospective analysis of adult patients with CBAO was treated between 2015 and 2023 in the Department of Neurology, Klinikum Kassel. Inclusion criteria were basilar artery occlusion without brainstem infarction as well as patients with a basilar artery occlusion in whom revascularization could not be achieved and a follow-up period of at least 3 months. Results: A total of 15 patients were found. In five patients basilar artery occlusion was diagnosed as an incidental finding, four patients had neurological symptoms but no proven brainstem infarction (3 × transient ischemic attack, 1 × isolated posterior artery infarct) and six patients presented with acute basilar artery occlusion and a follow-up > 3 months. The most common site of occlusion was midbasilar (80%, n = 12), isolated (n = 7) or in combination with other locations (n = 5). In all cases collateralization could be demonstrated by the posterior communicating arteries. The most common vascular risk factors (VRF) were hypertension (100%) and hypercholesterolemia (67%). Conclusions: Patients with CBAO may present with only mild symptoms or may even be asymptomatic. This condition may be survived for a long time. The high percentage of vascular risk factors and further cerebral vessel occlusions suggest arteriosclerosis as the major causing factor of CBAO. [ABSTRACT FROM AUTHOR]

We quantified temporal dynamics of wood storage, input, and transport over a 24‐year period in adjacent old‐growth and second‐growth forested reaches in Mack Creek, a third‐order stream in the Cascade Range of Oregon. The standing stocks of large wood in the old‐growth reach exceeded those at the second‐growth reach by more than double the number of wood pieces and triple the wood volume. Annual inputs of large wood were highly variable. Wood numbers delivered into the old‐growth reach were 3× higher and wood volume 10× greater than in the second‐growth reach. The movement of number and volume of logs did not differ significantly between the two reaches over time. Less than 2% of the logs moved in most years, and the highest proportion moved in the year of the 1996 flood (9% in old growth and 22% in second growth). Most of the large wood aggregated as jams in both reaches. The second‐growth reach lacked major jams, but 29% of the logs in the old growth were in full‐channel spanning jams. Long‐term observations of annual storage, input, and movement reveal the temporal dynamics of wood rather than static representations of the characteristics of wood. Input events and transport of wood in Mack Creek were episodic and varied greatly over the 24‐year study, which illustrates one of the major challenges and opportunities for understanding the cumulative dynamics of wood in streams. [ABSTRACT FROM AUTHOR]

Background and Objectives: Despite numerous described techniques, laparoscopy has yet to replace open surgery as the gold standard for inguinal hernia (IH) repair in children. This may be due to many variables, including the lack of long-term follow-up and concern for increased recurrence. In this study, we present our long-term follow-up data on children undergoing percutaneous internal ring suturing (PIRS) for IH repair. Materials and Methods: This retrospective cohort study included children who underwent PIRS for IH between May 2013 and May 2021 at three tertiary care institutions, with at least three years of follow-up. Age at surgery, side of IH, presence of contralateral patent processus vaginalis, surgical and anesthesia time, and complications were noted. Parents were contacted to enquire about long-term complications, such as recurrence. Results: Long-term follow-up (average 6.9 ± 2.3 years) was available for 714 patients. For unilateral and bilateral procedures, the average surgical time was 13.6 ± 5.4 and 19.9 ± 3.0, and the average anesthesia time was 27.7 ± 12.9 and 33.9 ± 14.1 min, respectively. Complications were seen in 0.84% of patients and 1.2% of procedures, and recurrence was observed in 0.98% of patients and 0.78% of procedures. Conclusions: Our study, with a nearly 7-year follow-up, provides substantial evidence that PIRS is a safe and effective technique for IH repair in children, with low recurrence and complication rates. Despite the study's retrospective nature and limited sample size, it contributes valuable data supporting the use of PIRS in pediatric IH repair. [ABSTRACT FROM AUTHOR]

Background: Arterio-venous fistulas (AVF) are used as first-line access for hemodialysis (HD) in the pediatric population. The aim of this investigation was to describe a single-center experience in the creation of AVF, together with its patency in children. Methods: This single-center retrospective study included all patients aged ≤18 years with AVFs created between 1993 and 2023. The collected data included patients' demographics, hemodialysis history, intraoperative data, and required reinterventions in order to determine the impact of these variables on primary, primary-assisted, and secondary patency. Results: Fifty-seven patients were analyzed with a median age of 15 years (range, 7–18 years). Fifty-four forearm and four upper arm fistulas were performed. The median follow-up was 6.9 years (range, 0–23 years). The primary failure rate was 10.5%. The primary patency rate was 67.6%, 53.6%, 51.4%, and 38.1% after 1, 3, 5, and 10 years; primary-assisted patency was 72.9%, 62.8%, 60.6%, and 41.5%; and secondary patency was 87.3%, 81.3%, 76.8%, and 66.6% after 1, 3, 5, and 10 years in the studied population. Conclusions: AVFs showed an acceptable rate of primary failure and excellent long-term patency. In this context, AVFs are an appropriate option for HD access, especially in pediatric patients. [ABSTRACT FROM AUTHOR]

Purpose: High levels of physical activity have been documented in eating disorder patients. Our aim was to examine whether adolescent leisure-time physical activity is prospectively associated with eating disorders in adolescence and young adulthood. Methods: Finnish twins born in 1983–1987 reported their physical activity frequency at ages 12, 14, and 17. A subsample of participants underwent structured, retrospective interviews for eating disorders at the mean age of 22.4 years. Associations between female twins' physical activity and future eating disorders (571–683 twins/wave) were investigated with the Cox proportional hazards model. To illustrate the physical activity similarity of the co-twins in a twin pair, we used cross-tabulation of eating disorder–discordant twin pairs (13–24 pairs/wave). Results: After adjusting for several covariates, we found no statistically significant longitudinal association between physical activity and eating disorders. This applied when all eating disorders were combined but also when assessed separately as restrictive and non-restrictive eating disorders. Co-twins' physical activity in adolescence tended to be similar irrespective of their future eating disorder, supporting the results of the regression analysis. Conclusion: We observed no evidence of adolescent physical activity frequency being prospectively associated with eating disorders in female twins. Further longitudinal studies with larger sample sizes and more detailed physical activity data are needed. Level of evidence: III, evidence obtained from cohort or case–control analytic studies. [ABSTRACT FROM AUTHOR]

Biaxially prestressed large concrete structures of the confinement building in nuclear power plants (NPPs) should meet the safety requirement for the extension of the service time. Long‐term delayed strains of concrete are one of the key factors determining the safety factor in these structures. This article presents 30‐year long in situ measurement results of strain evolution of confinement buildings in four different NPPs. The delayed strains are predicted at a material level using the next‐generation Eurocode‐2, and the influence of temperature as proposed by the fib model code 2010, making use of delayed strain characteristics of the corresponding concrete from a previous study. We found that the default law given in Eurocode underestimates the delayed strain. However, with the possibility of adjusting the shrinkage and creep laws, the prediction results fit with a good accuracy for the in situ measurement. [ABSTRACT FROM AUTHOR]

Background: The time‐series data of the Normalized Difference Vegetation Index (NDVI) is a crucial indicator for global and regional vegetation monitoring. However, the current assessment of global and regional long‐term vegetation changes is subject to large uncertainties due to the lack of spatiotemporally continuous time‐series data sets. Methods: In this study, a long time‐series monthly NDVI data set with a spatial resolution of 250 m from 1982 to 2020 was developed by combining Moderate Resolution Imaging Spectroradiometer (MODIS) and AVHRR (Advanced Very High‐Resolution Radiometer) time‐series NDVI products using the Random Forest (RF) downscaling model. Results: Compared to the MODIS NDVI product, the fused product shows RMSE and mean absolute error ranging from 0 to 0.075 and from 0 to 0.05, respectively, with R2 values mostly above 0.7. Conclusions: The long time‐series NDVI products generated in this study are reliable in terms of accuracy and have great potential for long‐term dynamic monitoring of terrestrial ecosystems on the Qinghai–Tibet Plateau. [ABSTRACT FROM AUTHOR]

An experiment was carried out in rice crop on Vertisol (locally called as Kanhar) at research farm of College of Agriculture, IGKV, Raipur, during kharif 2019-20 entitled “Continuous application of chemical fertilizers and organics influenced the soil chemical properties and zinc content of rice in the vertisols of the Chhattisgarh Plain”. This study comprised of ten treatments: control (no fertilizer), 50% NPK (suboptimal dose), 100% NPK (optimal dose), 150% NPK (super optimal dose) and 100% NPK along with ZnSO4 @ 10 kg/ha, 100% NP, 100% N alone, 100% NPK along with farmyard manure @ 5t/ha, 50% NPK along with blue green algae @ 10 kg/ha and 50% NPK along with green manure @ 40 kg/ha. The experiment was laid out at randomized complete block design which was replicated four times. Long term effect of continuous application of chemical fertilizers and organic manures significantly influenced the physico-chemical properties viz. highest “organic carbon (0.67%) available N (252 kg/ha), P (29 kg/ha) and K (425 kg/ha) in 100% NPK + FYM and lowest was obtained under control treatment (0.45% OC), (177 N kg/ha), (10.1 P kg/ha) and (368 K kg/ha), respectively. The addition of farm yard manure and NPK also reduces soil acidity compared to NPK use alone. Among the treatment of 150% NPK accumulated more total soluble salts end of this treatment could be attributed to low residue will effect of fertilizers and nutrient removal by crop. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this retrospective study was to evaluate the outcomes of a two-piece implant system with a tube-in-tube internal connection after up to 15 years of clinical use. Material and methods: A retrospective follow-up examination of patients treated with internal tube-in-tube implants between 2003 and 2006 was conducted. The implant survival rates, peri-implant conditions (marginal bone loss, bleeding on probing, plaque index, probing depth), and technical complications were determined. Results: In total, 312 dental implants were placed in 152 patients. Of the original 152 patients enrolled, 245 implants in 112 patients were available for a follow-up evaluation after 11 to 15 years (mean observation time, 12.9 ± 1.1 years). The overall implant survival rate was 93.9%. Outcomes for MBL (1.49 ± 1.23 mm), PI (24.3 ± 22.2%), BOP (18.3 ± 28.7%), and PD (2.74 ± 1.21 mm) were observed. Selected parameters (time after implant surgery, smoking habits, bone augmentation (GBR)) showed an influence on MBL and PD. Conclusions: The internal tube-in-tube implant system showed favorable long-term results. The correlation of MBL and PD with the patient-specific factor smoking habit is in accordance with other studies. Clinical relevance: Camlog Root-Line implants with a tube-in-tube implant-abutment connection and a 1.6-mm polished neck configuration have demonstrated favorable long-term outcomes in daily clinical practice. However, it is important to note that these implants are no longer available on the market. [ABSTRACT FROM AUTHOR]

A business model, defined as the underlying logic of a company, is not permanent over time. Instead, companies need to introduce innovations in the business model to be competitive in the market. This is even more critical for family firms which are continuously looking for a way to obtain sustainable growth, together with satisfactory performance. The objective of this research is to analyze the impact that business model innovation activities have in the short/long-term growth and performance of family firms. This study was obtained from panel data made up of 112 valid responses from family firms involved in business model innovation. A composite model approach has been used for data analysis. The significant components of BMI that lead to greater growth and performance are identified, the distinction between long-term and short-term effects of BMI on those outcomes is made, and BMI is proven as an authoritative source of competitive advantage and growth in family firms. Those aspects are valuable insights for researchers and managers with regards to which innovation propositions help sustain growth and performance over time. [ABSTRACT FROM AUTHOR]

Prior studies suggest that the reductions in physical activity during Covid-19-related lockdowns impacted physical and mental health. Whether reductions in physical activity that occurred during lockdowns also relate to cognitive functions such as memory and attention is less explored. Here, we investigated whether changes in physical activity (PA) that occurred during and following Covid-19-related lockdowns could predict a variety of measures of cognitive performance in 318 young adults. Participants were assessed on their engagement in PA before, during, and after lockdowns. They also completed tests of cognitive control, working memory, and short-term memory following lockdown(s). As expected, engagement in PA decreased during lockdown and returned to near baseline levels thereafter. Decreases in PA during lockdown predicted individual differences in cognitive performance following lockdown. Greater reductions in PA during lockdown were associated with lower scores on the go/no-go task, a measure of cognitive control ability, and the n-back task, a measure of working memory performance. Larger post-lockdown increases in PA were associated with higher scores on the same tasks. Individual differences in pandemic-related stress and insomnia also predicted cognitive outcomes. These findings suggest that reductions of PA can predict cognitive performance, and underscore the importance of maintaining PA for cognitive health, especially in situations such as lockdowns.

Introduction. Chronic limb-threatening ischemia (CLTI) is a debilitating condition characterized by inadequate blood supply to the lower extremities, often leading to tissue damage, ulcers, and limb loss. Amputation-free survival (AFS) serves as a crucial measure in evaluating interventions and managing CLTI, emphasizing limb preservation, functional restoration, and prevention of recurrent ischemic events. Objectives. This study aimed to assess mid to long term AFS in CLTI patients treated with hybrid vascular techniques. Materials and Methods. Conducted over 24 months at the Emergency Hospital of Saint Pantelimon in Bucharest, Romania, the study enrolled 62 adult CLTI patients, tracking them postoperatively. Kaplan Meyer survival curves were used to assess AFS rates. Results. Findings revealed a high prevalence of cardiovascular risk factors among participants, with most undergoing infrainguinal bypass revascularization in association with proximal and/or distal angioplasty with or without stenting. Prior to intervention, the majority of patients exhibited advanced stages of ischemia, with trophic lesions predominantly confined to the toes. Analysis of AFS revealed a decline over time, with the majority of amputations occurring within three months post-revascularization. Notably, 64.5% of patients achieved amputation free complete wound healing within the first year, with 90% of them achieving this within the first six months. Complex wounds were associated with prolonged healing. Conclusions. The study shows a 75.2% AFS rate at 24 months, highlighting the effectiveness of hybrid revascularization techniques and proper wound care in optimizing outcomes for CLTI patients.

Abstract This article studies the intricate dynamics of family resilience within the Chinese productivist regime over the course of seven decades, emphasizing the instrumental role of public policy in shaping this resilience. Drawing on a dynamic approach, the research demonstrates how, across distinct periods of central planning and economic reform, policies have persistently harnessed families to advance economic objectives. Showing that the productivist regime’s double-edged role on family resilience emerged while public policies bolstered short-term family resilience in times of sustained economic growth and favorable demographics, and signs of family sector downturn—declining fertility rates, family dysfunctions—became evident, the current article underscores the challenges of a model that primarily perceives families as economic instruments. Advocating for a policy paradigm shift that harmonizes economic ambitions with family well-being, this study offers valuable insights for policy-makers and lays the groundwork for future research in comparative welfare systems.

Abstract Background The relaxation of the “zero-COVID” policy on Dec. 7, 2022, in China posed a major public health threat recently. Complete blood count test was discovered to have complicated relationships with COVID-19 after the infection, while very few studies could track long-term monitoring of the health status and identify the characterization of hematological parameters prior to COVID-19. Methods Based on a 13-year longitudinal prospective health checkup cohort of ~ 480,000 participants in West China Hospital, the largest medical center in western China, we documented 998 participants with a laboratory-confirmed diagnosis of COVID-19 during the 1 month after the policy. We performed a time-to-event analysis to explore the associations of severe COVID-19 patients diagnosed, with 34 different hematological parameters at the baseline level prior to COVID-19, including the whole and the subtypes of white and red blood cells. Results A total of 998 participants with a positive SARS-CoV-2 test were documented in the cohort, 42 of which were severe cases. For white blood cell-related parameters, a higher level of basophil percentage (HR = 6.164, 95% CI = 2.066–18.393, P = 0.001) and monocyte percentage (HR = 1.283, 95% CI = 1.046–1.573, P = 0.017) were found associated with the severe COVID-19. For lymphocyte-related parameters, a lower level of lymphocyte count (HR = 0.571, 95% CI = 0.341–0.955, P = 0.033), and a higher CD4/CD8 ratio (HR = 2.473, 95% CI = 1.009–6.059, P = 0.048) were found related to the risk of severe COVID-19. We also observed that abnormality of red cell distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC), and hemoglobin might also be involved in the development of severe COVID-19. The different trajectory patterns of RDW-SD and white blood cell count, including lymphocyte and neutrophil, prior to the infection were also discovered to have significant associations with the risk of severe COVID-19 (all P

Disasters, disaster risks, and disaster risk management (DRM) present complex temporalities that must be taken into consideration when conducting evaluations that assist the choice of new strategies. Given the non-linearity of change, including long-term perspectives can modify the evaluation results and recommendations, but little is known about how time horizons are selected in DRM evaluation. This exploratory study investigates the determinants that affect what time horizon is considered in DRM evaluation. 12 semi-structured interviews with professional evaluators from different parts of the world were conducted in spring 2022. Their experiences indicate that the interpretation of what is long term in DRM evaluation is context-dependent. The factors determining if time horizons are expanded or narrowed relate to four categories: the actors involved in the evaluation, the purpose of the evaluation, the resources available to conduct the evaluation, and the specific DRM context. It is concluded that DRM evaluation seems to be quite similar to other public policy evaluations, except the DRM context that plays an important role by determining the timing of the evaluation, which itself affects what time horizon should be and/or is considered.

ABSTRACTLong-term, high-resolution soil moisture (SM) is a vital variable for understanding the water-energy cycle and the impacts of climate change on the Qinghai-Tibet Plateau (QTP). However, most existing satellite SM data are only available at coarse scale (~25 km) and suffer a lot from data gaps due to satellite orbit coverage and snow cover, especially on the QTP. Although substantial efforts have been devoted to downscale SM utilizing multiple soil moisture indices (SMIs) or diverse machine learning (ML) methods, the potentials of different SMIs and ML approaches in SM downscaling on the complex plateau remain unclear, and there is still a necessity to obtain an accurate, long-term, high-resolution and seamless SM data over the QTP. To address this issue, this study generated the long-term, high-accuracy and seamless soil moisture dataset (LHS-SM) over the QTP during 2001–2020 using a two-step downscaling method (first downscaling then merging). Firstly, the daily SM data from the Climate Change Initiative program of the European Space Agency (ESA CCI) was downscaled to 1 km utilizing five ML approaches. Then, a dynamic data merging method that considers spatiotemporal nonstationary error was applied to derive the final LHS-SM data. The performance of fifteen SMIs was also assessed and the optimal indexes for downscaling were identified. Results indicated that the shortwave infrared band-based indices had better performance than the near infrared band-based and energy-based indices. The generated LHS-SM data exhibited satisfying accuracy (mean R = 0.52, ubRMSE = 0.047 m3/m3) and certain improvement to the ESA CCI SM data both at station and network scales. Compared with existing 1 km SM datasets, the LHS-SM data also showed the best performance (mean R = 0.62, ubRMSE = 0.047 m3/m3), while existing datasets either failed to fully characterize the spatial details or had some data gaps and unreasonable distributions. Strong spatial heterogeneity was observed in the SM dynamics during 2001–2020 with the southwest and northeast showing a “dry gets wetter” scheme and the southeast presenting a “wet gets drier” trend. Overall, the LHS-SM dataset gained its added values by compensating the drawbacks of existing 1 km SM products over the QTP and was much valuable for many regional applications.

Background: Benralizumab has been shown to restore good control of severe eosinophilic asthma (SEA). Robust data on benralizumab effectiveness over periods longer than 2 years are scarce. Methods: This retrospective multicentric study was conducted on 108 Italian SEA patients treated with benralizumab for up to 36 months. Partial and complete clinical remission (CR) were assessed. Data were analyzed with descriptive statistics or using linear, logistic, and negative binomial mixed-effect regression models. Results: At 36 months, benralizumab reduced the exacerbation rate by 89% and increased the forced expiratory volume in 1 second (FEV1) (+440 mL at 36 months, p < 0.0001). Benralizumab improved asthma control as well as sinonasal symptoms in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). Up to 93.33% of patients either reduced or discontinued OCS; benralizumab also decreased ICS use and other asthma medications. Overall, 84.31% of patients achieved partial or complete CR. Conclusions: Benralizumab improved asthma and sinonasal outcomes up to 36 months. These findings support the potential of benralizumab to induce CR, emphasizing its role as a disease-modifying anti-asthmatic drug for the management of SEA. Further research is warranted to expand these findings by minimizing data loss and assessing benralizumab's long-term safety. [ABSTRACT FROM AUTHOR]

Background: Gaucher disease (GD) is a rare, autosomal, recessive condition characterized by hepatosplenomegaly, thrombocytopenia, anemia, and bone abnormalities, often requiring life-long treatment. Velaglucerase alfa has improved hematologic and visceral parameters in clinical trials; however, limited long-term efficacy and safety data are available. Methods: The Gaucher Outcome Survey (GOS), a structured and validated international registry for patients with confirmed GD, provides an opportunity to evaluate long-term data from patients receiving velaglucerase alfa. Results: This analysis included 376 treatment-naïve children and adults with GD enrolled in GOS, including 20 with type 3 GD, who initiated velaglucerase alfa through participation in clinical trials or as part of their clinical management and continued treatment for a mean (range) time of 6.6 (0.003–18.6) years. Initial improvements in hematologic and visceral parameters and the biomarkers glucosylsphingosine (lyso-GL1) and chitotriosidase were observed after one year of treatment and were maintained throughout the follow-up period. Of 129 (34.3%) patients who developed adverse events during the follow-up period, events were considered related to treatment in 33 (8.8%). None led to treatment discontinuation. There were 21 deaths overall, none of which were considered related to treatment. Conclusions: This analysis of data from the GOS registry supports the safety and efficacy of velaglucerase alfa in patients with GD. [ABSTRACT FROM AUTHOR]

The transition towards a sustainable future requires the reliable performance of the building's energy system in order for the building to be energy-resilient. "Energy resilient building in cold climates" is an emerging concept that defines the ability to maintain a minimum level of indoor air temperature and energy performance of the building and minimize the occupant's health risk during a disruptive event of the grid's power supply loss in a cold climate. The aim is to introduce an extensive definition of the energy resilience of buildings and apply it in case studies. This article first reviews the progress and provides an overview of the energy-resilient building concept. The review shows that most of the relevant focus is on short-term energy resilience, and the serious gap is related to long-term resilience in the context of cold regions. The article presents a basic definition of energy resilience of buildings, a systematic framework, and indicators for analyzing the energy resilience of buildings. Terms such as active and passive habitability, survivability, and adaptive habitable conditions are defined. The energy resilience indicators are applied on two simulated Finnish case studies, an old building and a new building. By systematic analysis, using the defined indicators and thresholds, the energy resilience performance of the buildings is calculated and compared. Depending on the type of the building, the results show that the robustness period is 11 h and 26 h for the old building and the new building, respectively. The old building failed to provide the habitability conditions. The impact of the event is 8.9 °C, minimum performance (Pmin) is 12.54 °C, and degree of disruption (DoD) is 0.300 for the old building. The speed of collapse (SoC) is 3.75 °C/h, and the speed of recovery (SoR) is 0.64 °C/h. On the other hand, the new building performed better such that the impact of the event is 4 °C, Pmin is 17.5 °C, and DoD is 0.138. The SoC is slow 3.2 °C/h and SoR is fast 0.80 °C/h for the new building. The results provide a pathway for improvements for long-term energy resilience. In conclusion, this work supports society and policy-makers to build a sustainable and resilient society. [ABSTRACT FROM AUTHOR]

Follicular lymphoma (FL) is an indolent lymphoma that becomes aggressive due to histological transformation (HT), leading to reduced survival. Patients with FL have different clinical courses and various treatment options. Some patients exhibit shorter survival and experience disease progression within 24 months of diagnosis/treatment (POD24); the optimal treatment remains an unmet needs. Thus, identifying factors that predict shorter survival is essential to stratify treatment and prolong the survival of patients with FL. To analyze risk factors for POD24 and HT in patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) as first‐line treatment, we performed this post‐hoc analysis of patients with advanced indolent B‐cell lymphoma in a randomized clinical trial wherein six cycles of R‐CHOP were administered every 2–3 weeks. The primary analysis showed no differences in outcomes, which enabled the analysis of 248 patients with FL, assigned to two arms. All histopathological specimens from the 300 enrolled patients were reviewed by three expert hematopathologists. Multivariable analysis implicated Follicular Lymphoma International Prognostic Index (FLIPI) intermediate (odds ratio [OR] 2.531, 95% confidence interval [CI] 0.676–9.466) and high‐ (OR 2.236, 95% CI 0.160–31.226) risks, B symptoms (OR 2.091, 95% CI 0.747–5.851), and grade 3A (G3A) (OR 1.833, 95% CI 0.634–5.299) as risk factors for POD24. Furthermore, multivariable analysis through a median follow‐up of 15.9 years implicated G3A (OR 2.628, 95% CI 0.806–8.575) and high‐risk FLIPI (OR 4.401, 95% CI 0.186–104.377) as risk factors for HT. However, an analysis limited to the first 10 years revealed that the prognostic factors elucidated from the longer‐term analysis had a greater impact on HT. G3A and high‐risk FLIPI may independently predict POD24 and HT, thereby informing treatment stratification of patients with untreated advanced‐stage FL in future trials, particularly to address the unmet needs of patients with POD24. [ABSTRACT FROM AUTHOR]

NDVI data are crucial for agricultural and environmental research. The Fengyun-3 (FY-3) series satellites are recognized as primary sources for retrieving NDVI products on a global scale. To apply FY-3 NDVI data for long-term studies, such as climate change, this study conducted a thorough evaluation to detect the potentials of the FY-3B and FY-3D satellites for generating a long time series NDVI dataset. For this purpose, the spatiotemporal consistency between the FY-3B and FY-3D satellites was evaluated, and their performances were compared. Then, a grey relational analysis (GRA) method was applied to detect the factors influencing the consistency among the different satellites, and a gradient boosting regression (GBR) model was constructed to create a long-term FY-3 NDVI product. The results indicate an overall high consistency between the FY-3B and FY-3D NDVIs, suggesting that they could be used as complementary datasets for generating a long-term NDVI dataset. The correlations between the FY-3D NDVI and the MODIS NDVI, as well as the leaf area index (LAI) measurements, were both higher than those of FY-3B, which indicates a better performance of FY-3D in retrieving NDVI data. The grey correlation degrees between the NDVI differences and four parameters, which were land cover (LC), DEM, latitude (LAT) and longitude (LON), were calculated, revealing that the LC was the most related to the NDVI differences. Finally, a GBR model with FY-3B NDVI, LC, DEM, LAT and LON as the input variables and FY-3D NDVI as the target variable was established and achieved a robust performance. The R values between the GBR-estimated NDVI and FY-3D NDVI reached 0.947, 0.867 and 0.829 in the training, testing and validation datasets, respectively, indicating the feasibility of the established model for generating long time series NDVI data by combining data from the FY-3B and FY-3D satellites. [ABSTRACT FROM AUTHOR]

Fiscal policy should be contractionary during economic expansion and expansionary during recessions. The objective of this article is to investigate the nature of long-term discretionary fiscal policy in Brazil in relation to the level of economic activity and the terms of trade. A fiscal policy variable without cyclical effects was chosen, and the results of the cointegration analysis indicate that long-term fiscal policy is destabilizing; this findings parallels those in the literature. However, in regard to trade cycles, this policy prevents their amplification. [ABSTRACT FROM AUTHOR]

Objectives: Sudden smell loss is one of the early symptoms of COVID‐19. Although it is stated that the loss of smell and taste following COVID‐19 improves within a few weeks, there are also cases that do not improve for a long time. The aim of this study is to reveal long‐term smell loss experiences after COVID‐19. Methods: A qualitative approach was adopted. We conducted semistructured interviews with 11 participants who had smell loss for at least 3 months. Interviews were recorded, transcribed and evaluated using a thematic analysis for qualitative data. Results: Nutrition and appetite, personal hygiene, threats to safety and emotional changes were the main themes created by the authors and were the areas where participant expressions focused. The participants used oral/nasal corticosteroid therapy for smell loss and received short‐term olfactory training, but could not find a solution. Conclusions: Long‐term smell loss problems, which were neglected during the pandemic period, should be carefully evaluated due to their negative effects. Understanding and focusing on the negative effects of loss of smell may contribute to the solution of long‐term smell loss problems. Patient and Public Contribution: Eleven participants who experienced long‐term loss of smell following COVID‐19 contributed to the study. They enriched the study by describing the effects of their experiences. There was no other participation or contribution from the public to the research. [ABSTRACT FROM AUTHOR]

As one key environmental regulation measure, China's pollution levy policy has been widely discussed; however, existing research has solely concentrated on the emissions reduction effect of pollution levy policies in the short term but has ignored long-term effectiveness, which may cause research bias. Thus, taking pollution levy standard adjustments as the core independent variable, this study builds firm-level pollution data and proves that the pollution levy policy is effective both in the short and long term. Furthermore, it demonstrates that the emissions reduction effect is achieved mainly by decreasing production and increasing the removal of sulfur dioxide ( S O 2 ). In addition, it is uncovered that the emissions reduction effect is mainly a result of two processes—the first is the greater use of clean energy and higher energy efficiency that can cause a decrease in the production of S O 2 , and the second is the utilization efficiency of waste gas treatment facilities, which can increase the removal of S O 2 . [ABSTRACT FROM AUTHOR]

Investigation on long-term effects of robot-assisted poststroke rehabilitation is challenging because of the difficulties in administration and follow-up of individuals throughout the process. A mobile hybrid neuromuscular electrical stimulation (NMES)-robot, i.e., exoneuromusculoskeleton (ENSM) was adopted for a single-group trial to investigate the long-term effects of the robotassisted self-help telerehabilitation on upper limb motor function after stroke. Twenty-two patients with chronic stroke were recruited to attend a 20-session telerehabilitation program assisted by the wrist/hand module of the ENMS (WHENMS). Participants were evaluated before, after, as well as at 3 months and 6 months after the training. The primary outcome measure was the Fugl-Meyer Assessment-Upper Extremity (FMA-UE), supplemented by secondary outcome measures of the FMA-UE of the shoulder and elbow (FMA shoulder/elbow), the FMA-UE of the wrist and hand (FMA wrist/hand), the Modified Ashworth Scale (MAS), the Action Research Arm Test (ARAT), the Wolf Motor Function Test (WMFT), the Functional Independence Measure (FIM), as well as electromyography (EMG) and kinematic measurements. Twenty participants completed the telerehabilitation program, with 19 returning for a 3-month follow-up, and 18 for a 6-month follow-up. Significantly improved clinical scores were observed after the training (p = 0.05). These improvements were maintained after 6 months in the FMA-UE, FMA shoulder/elbow, MAS at the wrist flexor, WMFT score, WMFT time, and FIM (p = 0.05). The maintained improvements in motor function were attributed to reduced muscular compensation, as indicated by EMG and kinematic parameters. The WH-ENMS-assisted self-help telerehabilitation could achieve long-lasting rehabilitative effects in chronic stroke. [ABSTRACT FROM AUTHOR]