317 results on '"LOBOMYCOSIS"'
Search Results
2. Lobomycosis in a Post-Covid 19 Patient: A Case Report and Review of Literature
- Author
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Sateesh S CHAVAN and Thotadamane Nagaraja CHANDRASHEKHAR
- Subjects
lobomycosis ,lacaziosis ,chain of yeasts ,sequential budding ,connecting tubes ,Pathology ,RB1-214 - Abstract
Aim: To document a case of lobomycosis and to discuss its epidemiology & diagnosis. Case Report: A 53-year-old male presented with a history of nasal congestion, nasal discharge, and epistaxis following Covid 19 infection. On physical examination, there was necrotic slough in the nasal vestibule near the inferior turbinate. Scrapings and punch biopsy were taken from the lesion. Hematoxylin-eosin-stained sections showed necrotic and mucoid areas with mixed inflammatory cell infiltration and numerous budding yeasts 3- 7μm diameter in singles, and small clusters with single narrow based budding as well as multiple budding including sequential budding forming chains of yeasts. A diagnosis of Lobomycosis was made. Yeasts of lobomycosis are often confused with other yeasts such as P. brasiliensis, Candida spp., B. dermatitidis, and Cryptococci, but characteristic sequential budding with a chain of yeasts aid in the final diagnosis. Demonstration of yeasts with characteristic chains either in tissue sections or in potassium hydroxide (KOH) preparation of scraped material, exudate, or exfoliative cytology is the mainstay in the diagnosis as the organisms are uncultivable in vitro in culture medium.
- Published
- 2023
- Full Text
- View/download PDF
3. Fungal Infections of Implantation (Chromoblastomycosis, Mycetoma, Lobomycosis, and Entomophthoromycosis)
- Author
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Queiroz-Telles, Flavio, Santos, Daniel Wagner de C. L., Hospenthal, Duane R., editor, Rinaldi, Michael G., editor, and Walsh, Thomas J., editor
- Published
- 2023
- Full Text
- View/download PDF
4. Fungal Density in Lobomycosis in French Guiana: A Proposal for a New Clinico-Histological and Therapeutic Classification.
- Author
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Grotta, Geoffrey, Couppie, Pierre, Demar, Magalie, Drak Alsibai, Kinan, and Blaizot, Romain
- Subjects
- *
NEGLECTED diseases , *GOLD miners , *GOLD mining , *MYCOSES - Abstract
Background: Lobomycosis is a rare cutaneous tropical neglected disease caused by the fungal agent Lacazia loboi, recently renamed Paracoccidioides lobogeorgii. Our objectives were to present all cases of lobomycosis diagnosed in French Guiana, to offer a precise description of their histopathological features and to propose a new clinico-histological prognostic classification. Methods: All cases of lobomycosis diagnosed in French Guiana between 1959 and 2022 were included. We looked for associations between the occurrence of relapses and the clinic-histological form. Results: 31 patients diagnosed with lobomycosis were included. An epidemiological shift was observed in the 2000s as Brazilian patients became the most important ethnic group. Gold mining, forestry and fishing/sailing were reported as professional exposures. New histological features, such as inflammatory "rosettes" formations were described. We describe two clinic-histological patterns: a major form (high fungal density and/or multifocal lesions) and a minor form (low fungal density, unifocal lesions, association with fewer relapses). Conclusions: The changing epidemiology of lobomycosis in French Guiana is characterized by a shift towards Brazilian patients, mostly gold miners. Minor forms should be treated with surgery, major forms with a combination of surgery followed by nultiple drug therapy (MDT) or posaconazole. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Lobomycosis in a Post-Covid 19 Patient: A Case Report and Review of Literature.
- Author
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CHAVAN, Sateesh S. and CHANDRASHEKHAR, Thotadamane Nagaraja
- Subjects
- *
LITERATURE reviews , *COVID-19 pandemic , *COVID-19 , *EXFOLIATIVE cytology , *POTASSIUM hydroxide - Abstract
Aim: To document a case of lobomycosis and to discuss its epidemiology & diagnosis. Case Report: A 53-year-old male presented with a history of nasal congestion, nasal discharge, and epistaxis following Covid 19 infection. On physical examination, there was necrotic slough in the nasal vestibule near the inferior turbinate. Scrapings and punch biopsy were taken from the lesion. Hematoxylin-eosin-stained sections showed necrotic and mucoid areas with mixed inflammatory cell infiltration and numerous budding yeasts 3-7µm diameter in singles, and small clusters with single narrow based budding as well as multiple budding including sequential budding forming "chains of yeasts". A diagnosis of Lobomycosis was made. Yeasts of lobomycosis are often confused with other yeasts such as P. brasiliensis, Candida spp., B. dermatitidis, and Cryptococci, but characteristic 'sequential budding' with a 'chain of yeasts" aid in the final diagnosis. Demonstration of yeasts with characteristic chains either in tissue sections or in potassium hydroxide (KOH) preparation of scraped material, exudate, or exfoliative cytology is the mainstay in the diagnosis as the organisms are uncultivable in vitro in culture medium. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. Etymologia: Lacazia loboi
- Author
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W. Clyde Partin
- Subjects
Lacazia loboi ,fungi ,fungal infections ,lobomycosis ,cutaneous mycosis ,dolphins ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Published
- 2023
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7. Fungal Skin Infections (Mycology)
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Prohic, Asja, Doss, Nejib, Hay, Roderick J., Diallo, Moussa, Gupta, Aditya K., Smoller, Bruce, editor, and Bagherani, Nooshin, editor
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- 2022
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8. Tropical Diseases of the Skin
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Tiwary, Anup Kumar, Kumar, Piyush, Vinay, Shilpa, Anand, Vikas, Barkat, Rizwana, Fatima, Talat, Smoller, Bruce, editor, and Bagherani, Nooshin, editor
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- 2022
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9. Lobomicosis (lacaziosis): cuatro casos nuevos en la Orinoquía y el Pacífico Colombiano.
- Author
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Galvis-Franco, Wilson, Jaramillo-Ayerbe, Felipe, Van den Enden-Medina, Lucia, and Aguilar-Medina, Nicolás
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INDIGENOUS peoples of South America , *DELAYED diagnosis , *MYCOSES , *RARE diseases , *INDIGENOUS peoples - Abstract
Lobomycosis is a rare fungal disease which affects people living in tropical areas with environmental and occupational characteristics that facilitate its appearance. Most of the patients are workers or inhabitants of jungle areas, and although it may occur in any race, its high prevalence in the indigenous people of the Amazon area stands out. Delays in diagnosis and treatment are common, as well as the difficulties in the therapeutic response, which leads to frequent recurrences and chronicity of the lesions. We present the report of four new cases of lobomycosis in men and women treated in health brigades with the Colombian Civil Air Patrol, in difficult-toaccess areas of the country, in the departments of Vichada and Chocó. This is a rare disease which should not be forgotten. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
10. Fungal Density in Lobomycosis in French Guiana: A Proposal for a New Clinico-Histological and Therapeutic Classification
- Author
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Geoffrey Grotta, Pierre Couppie, Magalie Demar, Kinan Drak Alsibai, and Romain Blaizot
- Subjects
lobomycosis ,Histopathology ,Therapeutics ,fungal disease ,Neglected Tropical Disease ,Biology (General) ,QH301-705.5 - Abstract
Background: Lobomycosis is a rare cutaneous tropical neglected disease caused by the fungal agent Lacazia loboi, recently renamed Paracoccidioides lobogeorgii. Our objectives were to present all cases of lobomycosis diagnosed in French Guiana, to offer a precise description of their histopathological features and to propose a new clinico-histological prognostic classification. Methods: All cases of lobomycosis diagnosed in French Guiana between 1959 and 2022 were included. We looked for associations between the occurrence of relapses and the clinic-histological form. Results: 31 patients diagnosed with lobomycosis were included. An epidemiological shift was observed in the 2000s as Brazilian patients became the most important ethnic group. Gold mining, forestry and fishing/sailing were reported as professional exposures. New histological features, such as inflammatory “rosettes” formations were described. We describe two clinic-histological patterns: a major form (high fungal density and/or multifocal lesions) and a minor form (low fungal density, unifocal lesions, association with fewer relapses). Conclusions: The changing epidemiology of lobomycosis in French Guiana is characterized by a shift towards Brazilian patients, mostly gold miners. Minor forms should be treated with surgery, major forms with a combination of surgery followed by nultiple drug therapy (MDT) or posaconazole.
- Published
- 2023
- Full Text
- View/download PDF
11. Dermatoses from Brazil
- Author
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Talhari, Sinésio, Talhari Cortez, Carolina Chrusciak, Ranawaka, Ranthilaka R., editor, Kannangara, Ajith P., editor, and Karawita, Ajith, editor
- Published
- 2021
- Full Text
- View/download PDF
12. Subcutaneous and Systemic Mycoses
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Arseculeratne, S. N., Singal, Archana, Ranawaka, Ranthilaka R., Ranawaka, Ranthilaka R., editor, Kannangara, Ajith P., editor, and Karawita, Ajith, editor
- Published
- 2021
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13. A review of lobomycosis and lobomycosis-like skin disease in cetaceans worldwide, with new data from the Gulf of Guayaquil, Ecuador.
- Author
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Van Bressem MF, Félix F, and Van Waerebeek K
- Subjects
- Animals, Ecuador epidemiology, Paracoccidioides isolation & purification, Cetacea microbiology, Prevalence, Risk Factors, Male, Skin microbiology, Skin pathology, Female, Paracoccidioidomycosis veterinary, Paracoccidioidomycosis epidemiology, Paracoccidioidomycosis microbiology, Paracoccidioidomycosis pathology, Lobomycosis pathology, Lobomycosis microbiology, Lobomycosis veterinary, Lobomycosis epidemiology
- Abstract
Lobomycosis, also called paracoccidioidomycosis ceti, is a chronic mycotic cutaneous disease affecting odontocetes. Lobomycosis-like disease (LLD) has a clinical presentation consistent with lobomycosis but lacks a histological and molecular diagnosis. We review the literature on lobomycosis aetiology, clinical signs and pathogenesis, species affected and geographic distribution and examine the factors influencing the presence, transmission and prevalence of the disease, to better understand its ecology. In addition, we provide unpublished information on LLD in two common bottlenose dolphin (Tursiops truncatus) communities inhabiting the Gulf of Guayaquil, Ecuador. Lobomycosis and LLD occur in Delphinidae from the Atlantic, Pacific, and Indian Oceans between 33°N and 35°S. Primary risk factors include habitat, sex, age, sociality, and pollution. In dolphins from the Americas and Japan, lobomycosis is caused by Paracoccidioides ceti, family Ajellomycetaceae. The disease is characterized by cutaneous granulomatous lesions that may occur anywhere on the body, grow to large size, and may ulcerate. Histologically, the lesions consist of acanthosis and histiocytic granulomas between the skin and subcutaneous tissues, with inflammatory changes that extend deep into the dermis. Multiple yeast cells with a double refringent layer stained positive using Gomori-Grocott methenamine silver in the dermis of a T. truncatus from Ecuador diagnosed with LLD since 2011, a first record for the Southeast Pacific. Injuries may enable the entry of P. ceti into the dermis while skin contact likely favours transmission, putting males at higher risk than females. Lobomycosis and LLD may have a negative impact on small communities already threatened by anthropogenic factors., (© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.)
- Published
- 2024
- Full Text
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14. Jorge Lobo’s disease with malignant degeneration to squamous cell carcinoma: case report
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Arival Cardoso de Brito, Maraya de Jesus Semblano Bittencourt, Thainá da Silva Gonçalves, and Renata Henriques Cavalcante
- Subjects
Carcinoma ,squamous cell ,Lacazia ,Lobomycosis ,Dermatology ,RL1-803 - Abstract
Abstract Jorge Lobo’s disease (JLD) is a chronic, granulomatous fungal infection caused by the traumatic implantation of the fungus Lacazia loboi in the cutaneous and subcutaneous tissues, with the presence of isolated nodular and coalescent keloidal lesions. Malignant degeneration is rare. This case report describes a 64-year-old male patient with JLD for 30-years who showed a change in the aspect of a lesion in the left lower limb. Histopathological examination confirmed the progression to well-differentiated squamous cell carcinoma (SSC). JLD is highly prevalent in tropical and subtropical regions, requiring monitoring concerning the transformation into SSC in long-term lesions.
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- 2022
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15. A keloid-like tumour.
- Author
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Cataño, Juan Carlos and Londoño, Nicolas
- Subjects
- *
TUMORS , *BLASTOMYCOSIS - Published
- 2024
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16. Lobomycosis Epidemiology and Management: The Quest for a Cure for the Most Neglected of Neglected Tropical Diseases.
- Author
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Gonçalves, Franciely G., Rosa, Patrícia S., Belone, Andrea de F. F., Carneiro, Léia B., de Barros, Vania L. Q., Bispo, Rosineide F., Sbardelott, Yally A. da S., Neves, Sebastião A. V. M., Vittor, Amy Y., Woods, William J., and Laporta, Gabriel Z.
- Subjects
- *
NEGLECTED diseases , *DISEASE prevalence , *EPIDEMIOLOGY , *HEALTH services accessibility - Abstract
Lobomycosis is a chronic disease caused by Lacazia loboi, which is endemic to the Amazon rainforest, where it affects forest dwellers in Brazil. There is no disease control program and no official therapeutic protocol. This situation contributes to an unknown disease prevalence and unmet needs of people disabled by this disease who seek access to treatment. This review provides an update on the subject with an emphasis on therapeutic advances in humans. All relevant studies that addressed epidemiology, diagnosis, or therapeutics of lobomycosis were considered. Seventy-one articles published between 1931 and 2021 were included for a narrative literature review on the epidemiology and quest for a cure. An effective therapy for lobomycosis has been found following decades of research led by the State Dermatology Program of Acre in the Amazon rainforest, where the largest number of cases occur. This discovery opened new avenues for future studies. The main recommendations here, addressed to the Brazilian Ministry of Health, are for lobomycosis to become a reportable disease to ensure that disease prevalence is measured, and that it be prioritized such that affected individuals may access treatment free-of-charge. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
17. Lobomycosis: exuberant presentation with malignant transformation
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Wanessa da Costa Lima, Sidharta Quercia Gadelha, Mara Lúcia Gomes de Souza, and Virginia Vilasboas Figueiras
- Subjects
Carcinoma ,squamous cell ,Lobomycosis ,Mycosis fungoides ,Skin ulcer ,Dermatology ,RL1-803 - Abstract
Abstract Lobomycosis is a chronic granulomatous infection caused by the yeast Lacazia loboi, typically found in tropical and subtropical geographical areas. Transmission occurs through traumatic inoculation into the skin, especially in exposed areas, of men who work in contact with the soil. Lesions are restricted to the skin and subcutaneous tissue, with a keloid-like appearance in most cases. The occurrence of squamous cell carcinoma on skin lesions with a long evolution is well known; however, there are scarce reports of lobomycosis that developed into squamous cell carcinoma. The authors report a patient from the Brazilian Amazon region, with lobomycosis and carcinomatous degeneration, with an unfavorable outcome, due to late diagnosis.
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- 2022
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18. Macrophage immunophenotypes in Jorge Lobo's disease and lepromatous leprosy- A comparative study.
- Author
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Sasso, BM, Vallarelli, AFA, Rosa, PS, Belone, AFF, Velho, PENF, and Cintra, Maria Leticia
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MACROPHAGES , *MACROPHAGE activation , *IMMUNE response , *HANSEN'S disease , *COMPARATIVE studies - Abstract
Jorge Lobo's disease (JLD) and lepromatous leprosy (LL) share several clinical, histological and immunological features, especially a deficiency in the cellular immune response. Macrophages participate in innate and adaptive inflammatory immune responses, as well as in tissue regeneration and repair. Macrophage function deficiency results in maintenance of diseases. M1 macrophages produce pro-inflammatory mediators and M2 produce anti-inflammatory cytokines. To better understand JLD and LL pathogenesis, we studied the immunophenotype profile of macrophage subtypes in 52 JLD skin lesions, in comparison with 16 LL samples, using a panmacrophage (CD68) antibody and selective immunohistochemical markers for M1 (iNOS) and M2 (CD163, CD204) responses, HAM56 (resident/fixed macrophage) and MAC 387 (recently infiltrating macrophage) antibodies. We found no differences between the groups regarding the density of the CD163, CD204, MAC387+ immunostained cells, including iNOS, considered a M1 marker. But HAM56+ cell density was higher in LL samples. By comparing the M2 and M1 immunomarkers in each disease separately, some other differences were found. Our results reinforce a higher M2 response in JLD and LL patients, depicting predominant production of anti-inflammatory cytokines, but also some distinction in degree of macrophage activation. Significant amounts of iNOS + macrophages take part in the immune milieu of both LL and JLD samples, displaying impaired microbicidal activity, like alternatively activated M2 cells. • Jorge Lobo's disease (JLD) and lepromatous leprosy (LL) have higher M2 response. • There is some distinction in degrees of macrophage activation in LL and JLD. • The immunohistochemical expression patterns of macrophage lineages align with the chronic clinical course of the diseases. • Gaucher-like cells in JLD are probably the result of more pronounced fungicidal activity of the M1 macrophage component. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
19. Lobomicosis en un soldado militar procedente del Chocó.
- Author
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Noguera-Castro, Verónica, Patricia Castillo-González, Diana, and Fernando Palma-Escobar, Luis
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- *
IDENTIFICATION of fungi , *DERMATOPHYTES , *SYMPTOMS , *MYCOSES , *ITRACONAZOLE , *PARACOCCIDIOIDOMYCOSIS - Abstract
Lobomycosis is a rare subcutaneous mycosis, prevalent in the tropical and subtropical regions of Central and South America, with a predominance in the Amazon forest. It is caused by the traumatic implantation of the Lacazia loboi fungus in the skin and subcutaneous tissue. Its clinical manifestations are solitary or multiple keloid-type dermal nodules that converge to form slow-growing, painless plaques. Diagnosis is made by histopathological identification of the fungus. For treatment, surgical removal of the lesions is the choice, associated with itraconazole and clofazimine when there are disseminated lesions, but the results are not highly effective as reported in the literature. We present a case of Lobomycosis in a male professional soldier of the National Army from Choco, who initially presented a papule with subsequent progression to a nodule on the left leg of 15 years of evolution. In this article we highlight the clinical and diagnostic characteristics of the disease. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
20. Extensive, multifocal lobomycosis.
- Author
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Hornberger, Maria M., Farnsworth, G. Strider, Vilela, Raquel, Mendoza, Leonel, and Bandino, Justin P.
- Subjects
- *
CUTANEOUS leishmaniasis , *LEISHMANIASIS , *KELOIDS , *TRANSFORMING growth factors-beta - Abstract
Keywords: blastomycosis; DNA sequencing; lacaziosis; lobomycosis; South America EN blastomycosis DNA sequencing lacaziosis lobomycosis South America 957 959 3 10/14/22 20221101 NES 221101 Lobomycosis, also known as lacaziosis or keloidal blastomycosis, is a slowly progressive, chronic fungal infection of the skin caused by the organism I Lacazia loboi i endemic to the subtropical regions of Central and South America.1-4 Most cases of lobomycosis have a preceding history of skin trauma with a variable clinical presentation.2,3 Treatment of lobomycosis is exceptionally challenging, especially given its prolonged incubation period and frequent delay in diagnosis.2,4 We report a case of widespread lobomycosis with the formation of deep satellite lesions as well as laboratory confirmation and related genetic findings via DNA sequencing. Punch biopsies of the left knee and left forearm lesions were performed for histopathology and culture. Blastomycosis, DNA sequencing, lacaziosis, lobomycosis, South America. [Extracted from the article]
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- 2022
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21. Case for diagnosis. Keloidal cord-like lesion on the leg
- Author
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Flaviano da Silva Oliveira, Nadya Picanço Lopes, Carolina Talhari, and Antonio Schettini
- Subjects
Histology ,Lacazia ,Lobomycosis ,Dermatology ,RL1-803 - Abstract
Abstract We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. The diagnosis was lobomycosis. Although the keloidal lesions presented by this patient are typical of lobomycosis, their linear distribution along the left lower limb is unusual.
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- 2020
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22. Epidemiologic and Clinical Progression of Lobomycosis among Kaiabi Indians, Brazil, 1965–2019
- Author
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Marcos C. Florian, Douglas A. Rodrigues, Sofia B.M. de Mendonça, Arnaldo L. Colombo, and Jane Tomimori
- Subjects
lobomycosis ,epidemiology ,fungus ,Lacazia loboi ,Kaiabi Indians ,South American ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Lobomycosis is a rare granulomatous skin disease with a high prevalence in the Amazon region. The Kaiabi Indians are an especially affected group. We studied the current epidemiologic and clinical progression of lobomycosis among the Kaiabi in Brazil, from initial case reports in 1965 through 2019. A total of 60 lobomycosis cases had been reported among the Kaiabi, and we identified 3 new cases in our review. Of 550 cases of lobomycosis ever reported worldwide, 11.5% were among the Kaiabi. We note a high incidence among female Kaiabi and a precocious onset of disease in this indigenous population. Male Kaiabi frequently are infected with the multicentric form and women more frequently exhibit the localized form. Ulcerated lesions are observed more often in the multicentric form. The prevalence among this indigenous group could be explained by genetic susceptibility and lifestyle, which exposes them to a particular agent in the habitats in which they live.
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- 2020
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23. Dermatologic Fungal Neglected Tropical Diseases-Part I. Epidemiology and Clinical Features.
- Author
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Curtis KL, Gold JAW, Ritter JM, Rosen T, Santos DWCL, Smith DJ, and Lipner SR
- Abstract
In this part 1 of a 2-part continuing medical education series, the epidemiology, clinical features, and diagnostic methods for fungal skin neglected tropical diseases (NTDs), which include eumycetoma, chromoblastomycosis, paracoccidioidomycosis, sporotrichosis, emergomycosis, talaromycosis, and lobomycosis, are reviewed. These infections, several of which are officially designated as NTDs by the World Health Organization (WHO), cause substantial morbidity and stigma worldwide and are receiving increased attention due to the potential for climate change-related geographic expansion. Domestic incidence may be increasing in the setting of global travel and immunosuppression. United States dermatologists may play a central role in early detection and initiation of appropriate treatment, leading to decreased morbidity and mortality., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
- Full Text
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24. Dermatologic Fungal Neglected Tropical Diseases-Part II. Management and Morbidity.
- Author
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Curtis KL, Gold JAW, Ritter JM, Rosen T, Santos DWCL, Smith DJ, and Lipner SR
- Abstract
In this part 2 of a 2-part continuing medical education series, the management, outcomes, and morbidities for fungal skin neglected tropical diseases (NTDs), including eumycetoma, chromoblastomycosis, paracoccidioidomycosis, sporotrichosis, emergomycosis, talaromycosis, and lobomycosis are reviewed. While fungal skin NTDs are associated with poverty in resource-limited settings, they are more often associated with immunosuppression and global migration in the United States. These infections have a high morbidity burden, including disfigurement, physical disability, coinfection, malignant transformation, mental health issues, and financial impact. For most fungal skin NTDs, management is difficult and associated with low cure rates. Dermatologists play a central role in initiating appropriate treatment early in disease course in order to improve patient outcomes., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
- Full Text
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25. Keloid-like lesions in a farmer from Amazonas
- Author
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Sidharta Quercia Gadelha, MD, Gabriela Evangelista de Almeida, MD, Alcidarta dos Reis Gadelha, MD, Mara Lúcia Gomes de Souza, MD, and Virginia Vilasboas Figueiras, MD
- Subjects
amphotericin B ,CO2 laser ,excisional surgery ,intralesional injection ,itraconazole ,lobomycosis ,Dermatology ,RL1-803 - Published
- 2021
- Full Text
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26. Lobomycosis in Soldiers, Colombia
- Author
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Claudia M. Arenas, Gerzain Rodriguez-Toro, Andrea Ortiz-Florez, and Ingrid Serrato
- Subjects
lobomycosis ,Jorge Lobo disease ,lacaziosis ,Lacazia loboi ,fungi ,fungal infections ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Lobomycosis is a disease that is endemic to the Amazon rainforest and is caused by the still uncultured fungus Lacazia loboi. This disease occurs in loggers, farmers, miners, fishermen, and persons living near coastal rivers of this region. We report 6 soldiers in Colombia in whom lobomycosis developed after military service in the Amazon area. The patients had nodular and keloid-like lesions on the face, neck, trunk, and limbs. The duration of illness ranged from 2 years to 15 years. The initial diagnosis was leishmaniasis on the basis of clinical manifestations and direct smear results, but biopsies confirmed the final diagnosis of lobomycosis. Treatment with surgical excision, itraconazole and clofazimine was satisfactory. However, the follow-up time was short. Healthcare professionals responsible for the diagnosis and treatment of skin diseases need to be able to recognize the clinical signs of lobomycosis and differentiate them from those of cutaneous leishmaniasis.
- Published
- 2019
- Full Text
- View/download PDF
27. Plastic surgery for the treatment of contagious diseases: lobomycosis
- Author
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Rodolfo Luis Korte, Cipriano Ferreira-Junior, Ana Elisa Kadri Castilho, Laryssa Fernanda Feitosa, and Anita Sperandio Porto
- Subjects
lobomycosis ,reconstructive surgical procedures ,communicable diseases ,advanced treatment ,recurrence ,lacazia ,Surgery ,RD1-811 - Abstract
Introduction: Lacaziosis is a rare disease that mainly affects workers in tropical areas, with approximately 500 cases reported worldwide. Lacaziosis is a parasitic disease caused by the saprophytic fungus Lacazia loboi; there is no specific treatment for this disease. Surgery is the most effective treatment for the deformities caused by the disease. However, it is a temporary treatment, since disease recurrence is frequently observed. Lacazia loboi affects two species of dolphin, Tursiops truncates and Sotalia guianensis. The available literature discusses the surgical treatment in a superficial way , because there are no specific studies describing the surgical treatment for this disease. Methods: Here, we describe our 8 years of experience with lacaziosis at the Hospital de Base de Porto Velho - Rondônia; a total of 22 patients underwent surgical treatment and were followed-up. Results: The majority of the patients (91%) had already submitted to at least one surgical treatment together with antifungal treatment. The patients presented with lesions with disease progression ranging from 5 months to 6 years prior to surgical treatment. Only two patients were treatment-naive. Conclusion: Our patients were followed-up; however, only 11 of the 22 patients returned for follow-up. Recurrences were observed in 9 of the 11 patients, with a latency period of 5 months.
- Published
- 2019
- Full Text
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28. Lobomycosis Epidemiology and Management: The Quest for a Cure for the Most Neglected of Neglected Tropical Diseases
- Author
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Franciely G. Gonçalves, Patrícia S. Rosa, Andrea de F. F. Belone, Léia B. Carneiro, Vania L. Q. de Barros, Rosineide F. Bispo, Yally A. da S. Sbardelott, Sebastião A. V. M. Neves, Amy Y. Vittor, William J. Woods, and Gabriel Z. Laporta
- Subjects
keloidal blastomycosis ,Jorge Lobo’s Disease ,Lacazia ,Lacaziosis ,lobomycosis ,Biology (General) ,QH301-705.5 - Abstract
Lobomycosis is a chronic disease caused by Lacazia loboi, which is endemic to the Amazon rainforest, where it affects forest dwellers in Brazil. There is no disease control program and no official therapeutic protocol. This situation contributes to an unknown disease prevalence and unmet needs of people disabled by this disease who seek access to treatment. This review provides an update on the subject with an emphasis on therapeutic advances in humans. All relevant studies that addressed epidemiology, diagnosis, or therapeutics of lobomycosis were considered. Seventy-one articles published between 1931 and 2021 were included for a narrative literature review on the epidemiology and quest for a cure. An effective therapy for lobomycosis has been found following decades of research led by the State Dermatology Program of Acre in the Amazon rainforest, where the largest number of cases occur. This discovery opened new avenues for future studies. The main recommendations here, addressed to the Brazilian Ministry of Health, are for lobomycosis to become a reportable disease to ensure that disease prevalence is measured, and that it be prioritized such that affected individuals may access treatment free-of-charge.
- Published
- 2022
- Full Text
- View/download PDF
29. Epidemiologic and Clinical Progression of Lobomycosis among Kaiabi Indians, Brazil, 1965-2019.
- Author
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Florian, Marcos C., Rodrigues, Douglas A., de Mendonça, Sofia B. M., Colombo, Arnaldo L., and Tomimori, Jane
- Subjects
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GRANULOMA , *RESEARCH , *RESEARCH methodology , *DERMATOMYCOSES , *FUNGI , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *DISEASE prevalence - Abstract
Lobomycosis is a rare granulomatous skin disease with a high prevalence in the Amazon region. The Kaiabi Indians are an especially affected group. We studied the current epidemiologic and clinical progression of lobomycosis among the Kaiabi in Brazil, from initial case reports in 1965 through 2019. A total of 60 lobomycosis cases had been reported among the Kaiabi, and we identified 3 new cases in our review. Of 550 cases of lobomycosis ever reported worldwide, 11.5% were among the Kaiabi. We note a high incidence among female Kaiabi and a precocious onset of disease in this indigenous population. Male Kaiabi frequently are infected with the multicentric form and women more frequently exhibit the localized form. Ulcerated lesions are observed more often in the multicentric form. The prevalence among this indigenous group could be explained by genetic susceptibility and lifestyle, which exposes them to a particular agent in the habitats in which they live. [ABSTRACT FROM AUTHOR]
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- 2020
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30. Skin fibrosis associated with keloid, scleroderma and Jorge Lobo's disease (lacaziosis): An immuno‐histochemical study
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Wagner Luiz Tafuri, Thaise Yumie Tomokane, Ana Maria Gonçalves Silva, Luciane Kanashiro‐Galo, David Miichael Mosser, Juarez Antonio Simões Quaresma, Carla Pagliari, and Mirian N. Sotto
- Subjects
Endothelial Cells ,Forkhead Transcription Factors ,Cell Biology ,Fibroblasts ,Fibrosis ,Pathology and Forensic Medicine ,Scleroderma, Localized ,Ki-67 Antigen ,Transforming Growth Factor beta ,Keloid ,Humans ,Vimentin ,Lobomycosis ,Molecular Biology ,Skin - Abstract
Fibrosis is a common pathophysiological response of many tissues and organs subjected to chronic injury. Despite the diverse aetiology of keloid, lacaziosis and localized scleroderma, the process of fibrosis is present in the pathogenesis of all of these three entities beyond other individual clinical and histological distinct characteristics. Fibrosis was studied in 20 samples each of these three chronic cutaneous inflammatory diseases. An immunohistochemical study was carried out to explore the presence of α-smooth muscle actin (α-SMA) and vimentin cytoskeleton antigens, CD31, CD34, Ki67, p16; CD105, CD163, CD206 and FOXP3 antigens; and the central fibrotic cytokine TGF-β. Higher expression of vimentin in comparison to α-SMA in all three lesion types was found. CD31- and CD34-positive blood vessel endothelial cells were observed throughout the reticular dermis. Ki67 expression was low and almost absent in scleroderma. p16-positive levels were higher than ki67 and observed in reticular dermis of keloidal collagen in keloids, in collagen bundles in scleroderma and in the external layers of the granulomas in lacaziosis. The presence of α-actin positive cells and rarely CD34 positive cells, observed primarily in keloids, may be related to higher p16 antigen expression, a measure of cell senescence. Low FOXP3 expression was observed in all lesion types. CD105-positive cells were mainly found in perivascular tissue in close contact with the adventitia in keloids and scleroderma, while, in lacaziosis, these cells were chiefly observed in conjunction with collagen deposition in the external granuloma layer. We did not find high involvement of CD163 or CD206-positive cells in the fibrotic process. TGF-β was notable only in keloid and lacaziosis lesions. In conclusion, we have suggested vimentin to be the main myofibroblast general marker of the fibrotic process in all three studied diseases, while endothelial-to-mesenchymal transition (EndoMT) and mesenchymal stem cells (MSCs) and M2 macrophages may not play an important role.
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- 2022
31. Plastic surgery for the treatment of contagious diseases: lobomycosis
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LUIS KORTE, RODOLFO, FERREIRA-JUNIOR, CIPRIANO, ELISA KADRI CASTILHO, ANA, FERNANDA FEITOSA, LARYSSA, and SPERANDIO PORTO, ANITA
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Lobomicose ,Doenças transmissíveis ,Lacazia ,Reconstructive surgical procedures ,Recurrence ,Advanced treatment ,Procedimentos cirúrgicos reconstrutivos ,Communicable diseases ,Lobomycosis ,Tratamento avançado ,Recidiva - Abstract
▪ RESUMO Introdução: Lacaziose é uma doença rara que afeta principalmente trabalhadores de áreas tropicais, sendo descritos aproximadamente 500 casos no mundo. A lacaziose é um doença parasitária causada pelo fungo saprófita Lacazia loboi, para o qual não existe um tratamento específico. A cirurgia é o tratamento mais eficiente para as deformidades causadas pela doença. Entretanto, é um tratamento temporário, uma vez que as recidivas são frequentes. Lacazia loboi acomete duas espécies de golfinhos, o Tursiops truncates e o Sotalia guianensis. A literatura aborda o tratamento cirúrgico de maneira superficial, pois não existem trabalhos específicos descrevendo o tratamento cirúrgico para essa doença. Métodos: Descrevemos aqui nossos 8 anos de experiência no Hospital de Base de Porto Velho-Rondônia com 22 casos submetidos a tratamento cirúrgico e acompanhados. Resultados: A maioria dos pacientes (91%) já se submeteram a pelo menos um tratamento cirúrgico associado ao tratamento antifúngico. Os pacientes apresentavam lesões com tempo de evolução entre 5 meses e 6 anos previamente ao tratamento cirúrgico. Apenas dois casos eram virgens de tratamento. Conclusão: Nossos pacientes foram acompanhados, mas apenas 11 dos 22 pacientes retornaram para acompanhamento. Recorrências foram observadas em 9 dos 11 pacientes, com um período de latência de 5 meses. ▪ ABSTRACT Introduction: Lacaziosis is a rare disease that mainly affects workers in tropical areas, with approximately 500 cases reported worldwide. Lacaziosis is a parasitic disease caused by the saprophytic fungus Lacazia loboi; there is no specific treatment for this disease. Surgery is the most effective treatment for the deformities caused by the disease. However, it is a temporary treatment, since disease recurrence is frequently observed. Lacazia loboi affects two species of dolphin, Tursiops truncates and Sotalia guianensis. The available literature discusses the surgical treatment in a superficial way, because there are no specific studies describing the surgical treatment for this disease. Methods: Here, we describe our 8 years of experience with lacaziosis at the Hospital de Base de Porto Velho - Rondônia; a total of 22 patients underwent surgical treatment and were followed-up. Results: The majority of the patients (91%) had already submitted to at least one surgical treatment together with antifungal treatment. The patients presented with lesions with disease progression ranging from 5 months to 6 years prior to surgical treatment. Only two patients were treatment-naive. Conclusion: Our patients were followed-up; however, only 11 of the 22 patients returned for follow-up. Recurrences were observed in 9 of the 11 patients, with a latency period of 5 months.
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- 2023
32. Fungal Infections of Implantation (Chromoblastomycosis, Mycetoma, Entomophthoramycosis, and Lacaziosis)
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Queiroz-Telles, Flavio, Santos, Daniel Wagner de C. L., Azevedo, Conceição de Maria Pedrozo S., Georgiev, Vassil St., Series editor, Hospenthal, Duane R., editor, and Rinaldi, Michael G., editor
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- 2015
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33. Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis
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Raquel Vilela, Gregory D. Bossart, Judy A. St. Leger, Leslie M. Dalton, John S. Reif, Adam M. Schaefer, Peter J. McCarthy, Patricia A. Fair, and Leonel Mendoza
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lacaziosis ,lobomycosis ,cutaneous granulomas ,Lacazia loboi ,Paracoccidioides brasiliensis ,P. lutzii ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Kex gene sequences of P. brasiliensis from dolphins showed 100% homology with sequences from cultivated P. brasiliensis, 73% with those of L. loboi, and 93% with those of P. lutzii. Parsimony analysis placed DNA sequences from dolphins within a cluster with human P. brasiliensis strains. This cluster was the sister taxon to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins is probably the cause of lacaziosis/lobomycosis, herein referred to as paracoccidioidomycosis ceti.
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- 2016
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34. Lobomycosis: a therapeutic challenge
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Marcelo Grossi Araújo, Nathalie Silva Cirilo, Soraya Neves Marques Barbosa dos Santos, Claudemir Roberto Aguilar, and Antonio Carlos Martins Guedes
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Cryosurgery ,Keloid ,Lacazia ,Lobomycosis ,Mycoses ,Dermatology ,RL1-803 - Abstract
Abstract: Lobomycosis or lacaziosis is a chronic granulomatous fungal infection caused by Lacazia loboi. Most cases are restricted to tropical regions. Transmission is believed to occur through traumatic inoculation in the skin, mainly in exposed areas. It is characterized by keloid-like nodules. There are only a few hundred cases reported. The differential diagnoses include many skin conditions, and treatment is difficult. The reported case, initially diagnosed as keloid, proved to be refractory to surgical treatment alone. It was subsequently approached with extensive surgery, cryotherapy every three months and a combination of itraconazole and clofazimine for two years. No signs of clinical and histopathological activity were detected during follow-up.
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- 2018
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35. Lobomycosis
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Hofman, Paul, van Krieken, J. H. J. M., Series Editor, and Hofman, Paul, editor
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- 2016
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36. Une cicatrice atypique chez un Brésilien.
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Garcia, M., Chanlin, R., Blanchet, D., Demar, M., Couppie, P., and Blaizot, R.
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PARACOCCIDIOIDES brasiliensis ,MYCOSES ,SKIN infections ,MOLECULAR diagnosis ,CLIMATE change ,KELOIDS - Abstract
Résumé: Une cicatrice atypique chez un Brésilien : lobomycose, une observation en Guyane française. La lobomycose est une infection fongique rare de la peau, endémique au bassin amazonien. D'évolution lente, elle se manifeste par des nodules cutanés semblables à des chéloïdes et est responsable d'une réaction granulomateuse histologique. L'agent causal, Lacazia loboi , n'a jamais été isolé du milieu extérieur et n'a jamais pu être cultivé. Le diagnostic est possible par son aspect unique en microscopie. La prise en charge thérapeutique est souvent décevante, avec un fort taux de rechute. Nous rapportons un nouveau cas en Guyane française et réalisons une revue de la littérature. Seuls 10 cas hors zone d'endémie ont été publiés, dont 2 n'ayant jamais voyagé, avec un délai diagnostic moyen de 21 ans. La phylogénétique a prouvé récemment que la lobomycose du dauphin n'est pas due à L. loboi mais à un agent fongique proche de Paracoccidioides brasiliensis. Le diagnostic par biologie moléculaire est possible dans certains centres. Du fait des modifications climatiques, la lobomycose pourrait atteindre des régions du monde jusque-là indemnes. Case report from French Guiana of an atypical keloid in a Brazilian man: Lobomycosis. Lobomycosis is a rare fungal skin infection, endemic to the Amazon basin. Its clinical manifestations are slow-growing keloid-like nodules, with a granulomatous reaction on histopathology. The etiological agent, Lacazia loboi , has never been isolated in the environment or cultured in a laboratory. Diagnosis is based on the typical appearance on microscopy. Treatment is disappointing, with a high recurrence rate. We report a new case in French Guiana and review the literature. Only 10 cases have been reported outside of the endemic area, 2 involving no travel; the mean time to diagnosis was 21 years. Phylogenetic analysis has recently proved that lobomycosis in dolphins is caused by a fungus more closely related to Paracoccidioides brasiliensis than to L. loboi (two very closely related species). Molecular diagnosis is possible in a few centers. Climate change may result in spreading lobomycosis to currently disease-free areas of the world. [ABSTRACT FROM AUTHOR]
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- 2019
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37. Morbilidad dermatológica en pacientes atendidos por la Patrulla Aérea Civil Colombiana, 2008-2018.
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Aguilar Medina, Nicolás, Van Den Enden Medina, Lucía, Jaramillo Ayerbe, Felipe, and Carvajal De los Ríos, Eduardo
- Abstract
Introduction: The Colombian Civil Air Patrol is a non-profit, private organization that, for almost 50 years, has provided specialized medical, surgical and emergency care for free to people in conditions of poverty and social or geographical exclusion, through monthly brigades in different rural areas of Colombia. On its archives, The Colombian Civil Air Patrol has kept valuable and must-know information. Material and methods: A descriptive, observational retrospective cross-sectional study was designed, which objective was to describe the sociodemographic, epidemiological and clinical characteristics of patients with dermatological pathologies attended by The Colombian Civil Air Patrol during the years 2008-2018. Results: 37 brigades were carried out in 26 populations of 14 departments of Colombia, where 2,975 patients with 3,424 diseases were attended by dermatologists. 50% of the study population was 31 years old or older. 69% were women, and 59.6% were mestizos. Acne was the most common disease, followed by pityriasis versicolor, acquired melanocytic nevus and seborrheic dermatitis. There were 6 cases of leprosy and 2 cases of lobomycosis. Discussion: There is a correlation in the frequency of diseases in the cities and in the rural sample of our study. However, the pruritus sine materia was found concentrated in the Colombian Pacific in women gatherers of piangua. Almost 50% of basal cell carcinomas were found in two Casanare populations. Conclusions: Studies are recommended to know the prevalence of some tropical infections in El Charco and La Primavera. Studies on the prevalence of national dermatological morbidity with adequate population samples are needed. [ABSTRACT FROM AUTHOR]
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- 2019
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38. Lobomycosis in Soldiers, Colombia.
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Arenas, Claudia M., Rodriguez-Toro, Gerzain, Ortiz-Florez, Andrea, and Serrato, Ingrid
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KELOIDS , *MILITARY personnel , *LOBOMYCOSIS , *DIFFERENTIAL diagnosis - Abstract
Lobomycosis is a disease that is endemic to the Amazon rainforest and is caused by the still uncultured fungus Lacazia loboi. This disease occurs in loggers, farmers, miners, fishermen, and persons living near coastal rivers of this region. We report 6 soldiers in Colombia in whom lobomycosis developed after military service in the Amazon area. The patients had nodular and keloid-like lesions on the face, neck, trunk, and limbs. The duration of illness ranged from 2 years to 15 years. The initial diagnosis was leishmaniasis on the basis of clinical manifestations and direct smear results, but biopsies confirmed the final diagnosis of lobomycosis. Treatment with surgical excision, itraconazole and clofazimine was satisfactory. However, the follow-up time was short. Healthcare professionals responsible for the diagnosis and treatment of skin diseases need to be able to recognize the clinical signs of lobomycosis and differentiate them from those of cutaneous leishmaniasis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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39. Jorge Lobo’s disease with malignant degeneration to squamous cell carcinoma: case report☆☆
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Maraya de Jesus Semblano Bittencourt, Arival Cardoso de Brito, Thainá da Silva Gonçalves, and Renata Henriques Cavalcante
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Pathology ,medicine.medical_specialty ,biology ,business.industry ,squamous cell ,Lacazia ,Carcinoma ,Carcinoma, squamous cell ,Traumatic implantation ,Dermatology ,Degeneration (medical) ,Lobo's disease ,medicine.disease ,biology.organism_classification ,Tropical/Infectoparasitary Dermatology ,Lesion ,Male patient ,medicine ,Lobomycosis ,Basal cell ,medicine.symptom ,business ,skin and connective tissue diseases - Abstract
Jorge Lobo’s disease (JLD) is a chronic, granulomatous fungal infection caused by the traumatic implantation of the fungus Lacazia loboi in the cutaneous and subcutaneous tissues, with the presence of isolated nodular and coalescent keloidal lesions. Malignant degeneration is rare. This case report describes a 64-year-old male patient with JLD for 30-years who showed a change in the aspect of a lesion in the left lower limb. Histopathological examination confirmed the progression to well-differentiated squamous cell carcinoma (SSC). JLD is highly prevalent in tropical and subtropical regions, requiring monitoring concerning the transformation into SSC in long-term lesions.
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- 2021
40. A global view on fungal infections in humans and animals: infections caused by dimorphic fungi and dermatophytoses
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Mariusz Dyląg, Dominik Łagowski, Aneta Nowakiewicz, and Sebastian Gnat
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medicine.medical_specialty ,Biology ,Applied Microbiology and Biotechnology ,Histoplasmosis ,03 medical and health sciences ,Tinea ,Environmental health ,Epidemiology ,medicine ,Animals ,Dermatomycoses ,Humans ,030304 developmental biology ,0303 health sciences ,Sporotrichosis ,030306 microbiology ,Public health ,Fungi ,General Medicine ,medicine.disease ,Geographic distribution ,Mycoses ,Lobomycosis ,Blastomycosis ,Dimorphic fungus ,Biotechnology - Abstract
Fungal infections are still underappreciated and their prevalence is underestimated, which renders them a serious public health problem. Realistic discussions about their distribution, symptoms, and control can improve management and diagnosis and contribute to refinement of preventive actions using currently available tools. This article represents an overview of dermatophytes and endemic fungi that cause infections in humans and animals. In addition, the impact of climate change on the fungal spread is discussed. The endemic fungal infections characterized in this article include coccidioidomycosis, histoplasmosis, blastomycosis, lobomycosis, emergomycosis, and sporotrichosis. Moreover, the geographic distribution of these fungi, which are known to be climate sensitive and/or limited to endemic tropical and subtropical areas, is highlighted. In turn, dermatophytes cause superficial fungal infections of skin, hairs, and nails, which are the most prevalent mycoses worldwide with a high economic burden. Therefore, the possibility of causing zoonoses and reverse zoonoses by dermatophytes is highly important. In conclusion, the article illustrates the current issues of the epidemiology and distribution of fungal diseases, emphasizing the lack of public programs for prevention and control of these types of infection.
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- 2021
41. Fungal diseases
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Kappe, Reinhard, Rimek, Dagmar, Müller, Johannes, Polak, Annemarie, Kappe, Reinhard, Rimek, Dagmar, Seibold, Michael, Tintelnot, Kathrin, and Jucker, E., editor
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- 2003
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42. Extensive, multifocal lobomycosis
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Justin P Bandino, Maria M. Hornberger, Leonel Mendoza, G. Strider Farnsworth, and Raquel Vilela
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Pathology ,medicine.medical_specialty ,Histology ,business.industry ,Biopsy ,Dermatology ,medicine.disease ,DNA sequencing ,Pathology and Forensic Medicine ,Humans ,Medicine ,Lobomycosis ,business ,Blastomycosis - Published
- 2021
43. Jorge Lobo’s disease
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Kalline Andrade de Carvalho, Marcos César Floriano, Milvia Maria Simões e Silva Enokihara, and Marta Regina Machado Mascarenhas
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Blastomycosis ,Lacazia ,Lobomycosis ,Dermatology ,RL1-803 - Abstract
AbstractJorge Lobo's Disease is a rare, chronic granulomatous cutaneous mycosis, which is typical of tropical and subtropical regions. It is caused by the traumatic implantation of the fungus Lacazia loboi into the skin and subcutaneous tissue. The disease was first described in 1931 by Jorge Lobo, in Recife (PE), Brazil. It is common in Central and South America, and predominates in the Amazon region. We report a case of Jorge Lobo's Disease, which had been initially referred as being paracoccidioidomycosis. We emphasize clinical and diagnostic features of the disease.
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- 2015
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44. Comparative effect of osmium tetroxide and ruthenium tetroxide on <scp> Lacazia loboi </scp> ultrastructure
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Gerzain Rodríguez-Toro, Jorge Rivera, Orlando Torres-Fernández, and Ladys Sarmiento‐Lacera
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Histology ,Osmium Tetroxide ,Lacazia ,Combined use ,02 engineering and technology ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,law ,medicine ,Humans ,Instrumentation ,biology ,030206 dentistry ,021001 nanoscience & nanotechnology ,medicine.disease ,biology.organism_classification ,Molecular biology ,Ruthenium tetroxide ,Microscopy, Electron ,Medical Laboratory Technology ,Osmium tetroxide ,chemistry ,Ultrastructure ,Ruthenium Compounds ,Lobomycosis ,Glutaraldehyde ,Anatomy ,Electron microscope ,0210 nano-technology - Abstract
Lobomycosis is a skin infection produced by the fungus Lacazia loboi, which mainly affects some indigenous and afro-descendant populations in Tropical America. We previously reported the comparative effect of osmium tetroxide (OsO4 ) and ruthenium tetroxide (RuO4 ) in the electron microscopy (EM) of other related microorganisms. The objective of this study is to compare the effect of postfixation with OsO4 and RuO4 in the ultrastructure of L. loboi yeasts. Skin biopsies on patients diagnosed with lobomycosis were fixed in glutaraldehyde at 3% and postfixed in the following solutions: (a) 1% OsO4 , (b) 0.2% RuO4 , and (c) OsO4 at 1% followed by RuO4 at 0.2%. They were then processed using the conventional method for EM. Unlike OsO4, the treatment with RuO4 revealed different shades of gray and electron dense bands in the cell wall and other cell components of L. loboi. The most notable finding was the presence of radial filamentous structures around the yeast, which made the image look like the sun. Postfixation with RuO4 revealed ultrastructural details that had not been previously reported for L loboi. The combined use of OsO4 and RuO4 in EM of microorganisms with cell walls can be useful to evaluate the effect of microbicide substances.
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- 2020
45. Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease.
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Ramírez Soto, Max Carlos and Malaga, German
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MYCOSES , *CHROMOBLASTOMYCOSIS , *LOBOMYCOSIS , *SPOROTRICHOSIS , *ENDEMIC diseases , *PUBLIC health , *SYSTEMATIC reviews - Abstract
Background There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs. Objectives This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses. Methods We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. The disease burden was determined in terms of prevalence (number of cases per 100,000 inhabitants) and the number of reported cases per year per region. Results A total of 26 studies were eligible for inclusion. Results showed that sporotrichosis was the most common subcutaneous mycosis (99.7%), whereas lobomycosis, chromoblastomycosis, and subcutaneous phaeohyphomycosis were rare. Cases of eumycetoma and subcutaneous zygomycosis were not found. Of the 25 regions, the burden of sporotrichosis was estimated for four regions classified as endemic; in nine regions, only isolated cases were reported. The highest burden of sporotrichosis was in Apurimac (15 cases/100,000 inhabitants; 57 cases/year), followed by Cajamarca (3/100,000 inhabitants; 30/year), Cusco (0.5/100,000 inhabitants; 4/year), and La Libertad (0.2/100,000 inhabitants; 2/year). In two regions, the mycoses predominantly affected children. Conclusions Sporotrichosis is the most common subcutaneous mycosis in Peru, with a high disease burden in Apurimac. Chromoblastomycosis, lobomycosis, and subcutaneous phaeohyphomycosis are rare mycoses in Peru. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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46. Lobomicose.
- Author
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Moura Filho, Francisco Ronaldo, Guimarães Grana, Aline, Sobreira Fernandes de Macedo, Gabriel Kenhinde, Lima Tupinambá, Walquiria, Reyes Romero, Sandra Adolfina, and Bandeira de Melo, Patricia Chicre
- Abstract
Lobomycosis or Jorge Lobo's disease is a chronic granulomatous infection, caused by the traumatic implantation of the fungus Lacazia loboi, that affects the skin and subcutis. This dermatosis is typical of tropical and subtropical regions and affects mainly active adult males working in the forest, but it has also been already diagnosed in dolphins. The lesions primarily involve exposed skin areas, such as the auricle, and the upper and lower limbs. Keilodal lesions are the main clinical presentation. Surgical removal is the therapeutic procedure of choice in the initial cases, whereas itraconazole and clofazimine, alone or in combination, may be used in disseminated lesions. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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47. Granular cell differentiation: A review of the published work.
- Author
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Cardis, Michael A., Ni, Jonathan, and Bhawan, Jag
- Abstract
Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. In light of this, it is important to be aware of the various entities that have been reported to exhibit granular cell morphology. In this review such tumors are discussed along with pertinent clinical and histopathological features. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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48. Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis.
- Author
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Vilela, Raquel, Bossart, Gregory D., St. Leger, Judy A., Dalton, Leslie M., Reif, John S., Schaefer, Adam M., McCarthy, Peter J., Fair, Patricia A., and Mendoza, Leonel
- Subjects
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SKIN inflammation , *PARACOCCIDIOIDES brasiliensis , *GRANULOMA , *LOBOMYCOSIS , *DOLPHINS , *FUNGAL phylogeny , *FUNGAL DNA , *DISEASES , *DIAGNOSIS , *DISEASE risk factors , *FUNGI classification , *ANIMAL experimentation , *ANIMAL diseases , *BIOPSY , *COMPARATIVE studies , *DERMATOMYCOSES , *DNA , *BIOLOGICAL evolution , *FUNGI , *RESEARCH methodology , *MEDICAL cooperation , *MYCOSES , *NUCLEOTIDES , *RESEARCH , *EVALUATION research - Abstract
Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Kex gene sequences of P. brasiliensis from dolphins showed 100% homology with sequences from cultivated P. brasiliensis, 73% with those of L. loboi, and 93% with those of P. lutzii. Parsimony analysis placed DNA sequences from dolphins within a cluster with human P. brasiliensis strains. This cluster was the sister taxon to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins is probably the cause of lacaziosis/lobomycosis, herein referred to as paracoccidioidomycosis ceti. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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49. M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis
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Arival Cardoso de Brito, Juarez Antônio Simões Quaresma, Tania Cristina Barboza, Luciane Kanashiro-Galo, Mirian Nacagami Sotto, Maria Irma Seixas Duarte, and Carla Pagliari
- Subjects
0301 basic medicine ,Immunopathogenesis ,Lacazia ,Veterinary (miscellaneous) ,Biopsy ,030106 microbiology ,Population ,Cell Plasticity ,Antigens, Differentiation, Myelomonocytic ,Nitric Oxide Synthase Type II ,Receptors, Cell Surface ,Lacaziosis ,Applied Microbiology and Biotechnology ,Microbiology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Antigens, CD ,medicine ,Macrophage ,M2 macrophages ,Humans ,education ,Lobomycosis ,Mycosis ,M1 macrophages ,education.field_of_study ,biology ,Arginase ,Macrophages ,medicine.disease ,biology.organism_classification ,Immunohistochemistry ,Immunoglobulin J Recombination Signal Sequence-Binding Protein ,Proto-Oncogene Proteins c-maf ,Immunology ,biology.protein ,Original Article ,Antibody ,Epidermis ,Agronomy and Crop Science ,CD163 - Abstract
Lacaziosis is a cutaneous chronic mycosis caused by Lacazia loboi. Macrophages are important cells in the host immune response in fungal infections. The macrophage population exhibits strong plasticity that varies according to the stimuli in the microenvironment of lesions M1 profile promotes a Th1 pattern of cytokines and a microbicidal function and M2 is related to Th2 cytokines and immunomodulatory response. We investigated the population of M1 and M2 polarized macrophages in human cutaneous lesions. A total of 27 biopsies from human lesions were submitted to an immunohistochemistry protocol using antibodies to detect M1 and M2 macrophages (Arginase-1, CD163, iNOS, RBP-J and cMAF). We could observe high number of cells expressing Arginase1, CD163 and c-MAF that correspond to elements of the M2 profile of macrophage, over iNOS and RBP-J (elements of the M1 profile). The results suggest a predominant phenotype of M2 macrophages, which have an immunomodulatory role and probably contributing to chronicity of Lacaziosis. Electronic supplementary material The online version of this article (10.1007/s11046-020-00450-z) contains supplementary material, which is available to authorized users.
- Published
- 2020
50. What is your diagnosis? Keloidal cord-like lesion on the leg
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Carolina Talhari, Antonio Pedro Mendes Schettini, Flaviano da Silva Oliveira, and Nadya Picanço Lopes
- Subjects
medicine.medical_specialty ,Histology ,Cord ,Lacazia ,Dermatology ,Lesion ,Silver stain ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Lobomycosis ,biology ,business.industry ,Anatomy ,biology.organism_classification ,medicine.disease ,What is your Diagnosis? ,030220 oncology & carcinogenesis ,Histopathology ,medicine.symptom ,business ,Reticular Dermis - Abstract
We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. The diagnosis was lobomycosis. Although the keloidal lesions presented by this patient are typical of lobomycosis, their linear distribution along the left lower limb is unusual.
- Published
- 2020
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