1. Investigations of the histopathological changes of ibuprofen over dose intake on the albino mice liver tissues.
- Author
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Alzwawy, Ateeqah Ghayth
- Subjects
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FATTY liver , *ANIMAL housing , *HUMIDITY , *BLOOD vessels , *LIVER cells - Abstract
Our study aim is to investigate the histopathological changes associated with prolonged administration of ibuprofen overdose orally intake on the albino mice liver tissues. Fifteen female albino mice were used in this study. Animals were housed in an environment with a 12-h light/dark cycle at 24˚C and a relative humidity of 50-70%. They were given free access to water and food, and the bedding was changed every other day. After 7 days of acclimation, animals were randomly divided into two groups: 5 animals for control group received normal saline orally and 10 animals treated group received 110 mg/kg mice body weight/da. The daily dose was administered orally in 0.1 ml of normal saline for four weeks, using the original gastric tube attached to a syringe needle head. Our results showed significant histopathological changes in liver tissue in responses to ibuprofen overloading. These changes ranged from hydropic degeneration, fatty liver changes, congested blood vessels and even hepatocytes necrosis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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