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Objective To investigate the clinical effects of sinus elevation surgery and implant restorationdue to insufficient bone massafter tooth extraction in patients with odontogenic maxillary sinusitis (OMS) and to provide a reference for use in clinical practice. Methods This study was reviewed and approved by the Ethics Committee, and informed consent was obtained from the patients. Forty-five teeth were extracted from patients with OMS in the maxillary posterior area (the study group). Sinus elevation and implantation were performed due to insufficient bone height in the implant area 6-8 months after tooth extraction in the study group. Forty-eight teeth were extracted from patients without "OMS" in the maxillary posterior area (the control group), and sinus elevation and implantation were performed due to insufficient bone height in the implant area 6-8 months after tooth extraction inthe control group. In the study group, 13 cases of discontinuous maxillary sinus floor bone and residual alveolar bone height of the maxillary sinus floor less than 4 mm were addressed with lateral wall sinus elevation, and the other 32 cases were addressed with crest-approach sinus elevation. In the control group, 8 cases of residual alveolar bone height less than 4 mm in the maxillary sinus floor were addressed with lateral wall sinus,and the other 40 cases were addressed with crest approach sinus elevation. Restorations were placed 6 to 8 months after surgery. The patients were followed up 21 days, 3 months, and 8 months after implantation and every 6 months after the placement of the restorations. The sinus bone gain (SBG), apical bone height (ABL) and marginal bone loss (MBL) were statistically analyzed 24 months after the restoration. Results The average preoperative mucosal thickness in the 45 patients in the study group was (1.556 ± 0.693) mm, which was significantly larger than that in the control group (1.229 ± 0.425) mm (P0.05). Conclusion After the extraction of teeth from patients with OMS, the inflammation of the maxillary sinus decreased, and the bone height and density in the edentulous area were restored to a certain degree. The effects of sinus floor lifting surgery and implant restoration do not differ between patients with and without OMS.

The presence of π gauge flux enabled by positive and negative hopping amplitude can lead to Möbius bands, which was recently demonstrated in both realistic acoustic and photonic lattices, twisted at k = π. Here, we show that the artificial gauge flux configuration can be achieved by exploiting the interactions between photonic s and p orbital-like fundamental modes in circular and peanut-shaped waveguides, respectively. By manipulating the interplay between the gauge fields and the crystal symmetry, we show that breaking the primitive translation symmetry through lattice site dimerization and deformation can cause the original Dirac semimetal phase, characterized by a four-fold Dirac point at the Brillouin zone center, to transform into various topological phases. The designed photonic waveguide array supports topological phases such as Möbius insulator and Weyl-like semimetal phases. Noticeably different to the existing cases, we explicitly show that the twisting Möbius bands cross each other at k = 0 due to the lattice gauging with alternating sign, which results in distinct beam dynamics excitation. We also present Weyl-like flat-band edge states in such photonics waveguide arrays. Our results suggest that such s − p hybridized photonic waveguide array servers as a convenient and flexible platform for studying topological physics, particularly in simulating the effects of gauge field in alternative configuration.

Diabetic kidney dysfunction is closely associated with renal fibrosis. Although the suppression of fibrosis is crucial to attenuate kidney damage, the underlying mechanisms remain poorly understood. In this study, renal injury in diabetic mice was induced by the intraperitoneal injection of streptozotocin (100 or 150 mg/kg) for 2 consecutive days. In the model mice, remarkable renal injury was observed, manifested by albuminuria, swelling of kidneys, and histopathological characteristics. The renal fibrosis was obviously displayed with high-intensity staining of fibrin, type IV collagen (Col IV), and fibronectin. The levels of Col IV and transforming growth factor-β1 were significantly increased in diabetic mice kidneys. The aggravated fibrotic process was associated with the overexpression of HMGB1, TLR2/4, and p-NF-κB. Furthermore, a high expression of F4/80 and CD14 indicated that macrophage infiltration was involved in perpetuating inflammation and subsequent fibrosis in the kidneys of diabetic mice. The results demonstrate that the severity of renal fibrosis is positively associated with the activation of HMGB1/TLR2/4 signaling in diabetes.

The jaw and femur are commonly used sites in basic research for modeling bone defects or inserting implants. An increasing number of studies have identified that the jaw and femur indeed show great differences in embryonic development and growth, histomorphology and bone metabolism. A literature review showed that, compared with the femur, the main osteogenic pathway of the jaw may have better osteogenic ability, and its stem cells have better proliferation and osteogenic differentiation ability. However, the jaw structure is less regular, the osteogenic differentiation ability of its osteoblasts is mineralization slightly weak, and the immune cells of the jaw are more sensitive to cytokines. These may be the reasons why the osseointegration of the jaw implant is different from that of the femur in animal experiments, but its specific mechanism has not been clarified.

Patients seeking implantation often have several systemic diseases, which will introduce complications to treatment. This paper reviews the risk assessments and prevention of systemic diseases in patients with oral implant therapy with the relevant literature. The patients with cardiovascular diseases are prone to stroke and cardiac arrest, and anticoagulants and antihypertensive drugs will complicate cases. The potential risks of endocrine system diseases are infections and crises caused by unstable hormone levels. The risks of respiratory diseases are dyspnea and swallowing devices. The difficulty of treating patients with neuropsychiatric diseases is attributable to poor cooperation and adverse effects of the drugs. Bone and joint system diseases may decrease the success of implantation. Hematological system, digestive system and kidney diseases may lead to hemorrhage. By inquiring about detailed medical and medication history, evaluating vital signs and detecting important objective indicators, performing targeted measures, discussing with specialists, and observing patients closely, clinicians can avoid the abovementioned risks.

Image monitoring of oil wear particles is currently only applicable to microflows and is susceptible to bubble interference. This paper develops an optical oil-monitoring system that can be used for large-diameter pipes with high flow rates. A shallow and wide observation cell with an equivalent diameter of Φ5 mm is designed to allow a theoretical maximum monitoring flow rate of about 8 L/min, which is a significant improvement over current image monitoring of generally less than Φ2 mm pipes. A low-magnification (0.8X – 5X) stereoscopic microscope head is used to improve the field of view and depth of field, and a high-speed camera is used to increase the flow range that can be monitored. A set of experimental platforms is also constructed to produce bubbles and wear particles separately. Images of the wear particles and bubbles are then collected for subsequent training and verification of image classification algorithms. A motion object extraction algorithm based on background differences and the Otsu method is used to extract debris and bubble images, and a convolutional neural network (CNN) algorithm is used to distinguish between bubbles and debris. Compared with the traditional morphological feature extraction method, histogram of oriented gradient (HOG) feature extraction method, k-nearest neighbor (KNN) classification algorithm, and support vector machine (SVM) classification algorithm, the CNN algorithm eliminates the tedious process of feature extraction and selection, and has better classification results. The experimental results show that the system can effectively collect wear particle and bubble images and classify them, and the classification accuracy can reach 91.8%.

For problems of low positioning accuracy of electromagnetic wave ranging positioning method due to underground electromagnetic interference and continuous measurement and storage of massive offline data in offline construction of fingerprint feature database by fingerprint positioning method, a region discretization mine target positioning method based on compressed sensing was proposed. Firstly, positioning area is divided into grids for discretization, and fingerprint feature database is constructed by offline measuring signal strength at the grid. Then, sparse position matrix containing target position information is obtained by compressed sensing with a small amount of signal strength sampled online, so as to estimate possible position of the target. Finally, the target is accurately positioned by grid centroid method. The experimental results show that the method achieves accurate positioning of mine target with higher positioning accuracy and less positioning time.

During the development of therapeutic microRNAs (miRNAs or miRs), it is essential to define their pharmacological actions. Rather, miRNA research and therapy mainly use miRNA mimics synthesized in vitro. After experimental screening of unique recombinant miRNAs produced in vivo, three lead antiproliferative miRNAs against human NSCLC cells, miR-22-3p, miR-9-5p, and miR-218-5p, were revealed to target folate metabolism by bioinformatic analyses. Recombinant miR-22-3p, miR-9-5p, and miR-218-5p were shown to regulate key folate metabolic enzymes to inhibit folate metabolism and subsequently alter amino acid metabolome in NSCLC A549 and H1975 cells. Isotope tracing studies further confirmed the disruption of one-carbon transfer from serine to folate metabolites by all three miRNAs, inhibition of glucose uptake by miR-22-3p, and reduction of serine biosynthesis from glucose by miR-9-5p and -218-5p in NSCLC cells. With greater activities to interrupt NSCLC cell respiration, glycolysis, and colony formation than miR-9-5p and -218-5p, recombinant miR-22-3p was effective to reduce tumor growth in two NSCLC patient-derived xenograft mouse models without causing any toxicity. These results establish a common antifolate mechanism and differential actions on glucose uptake and metabolism for three lead anticancer miRNAs as well as antitumor efficacy for miR-22-3p nanomedicine, which shall provide insight into developing antimetabolite RNA therapies.

Aero engine is a kind of thermodynamic machinery, which require have strict aerodynamic load, mechanical load and strong durability, its longevity depends largely on the life of its main components. In this paper, a series of studies are carried out on the strength of fan blades of CFM56 engine, which provide a reference value for improving the reliability of the engine. The finite element model of the engine fan is established by using CATIA’s finite element software.The centrifugal stress distribution of the fan at different speeds and the influence of torque on fans under different speeds are calculated respectively, and the static strength of the fan is checked.

Although we are surrounded by various kinds of rumors during the coronavirus disease pandemic, little is known about their primary content, what effect they might have on our emotions, and the potential factors that may buffer their effect. Combining qualitative (study 1 extracted 1907 rumors from top rumor-refuting websites using the Python Web Crawler and conducted content analysis) and quantitative (study 2 conducted an online survey adopting a three-wave design, N = 444) research methods, the current study revealed that government-related rumors accounted for the largest proportion of rumors during the outbreak stage of the pandemic and were positively associated with the public's negative emotions. We also found that trust in government negatively moderated the relationship between government-related rumors and negative emotions. Specifically, when people had low trust in government, exposure to government-related rumors was positively associated with negative emotions. However, when people had high trust in government, the association was non-significant. For positive emotions, we found no significant effects of government-related rumors. The findings highlight the importance of rumor control during public emergencies and cultivating public trust in government in the long run., Author(s): Yue Yuan [sup.1] , Shuting Yang [sup.1] , Xinying Jiang [sup.1] , Xiaomin Sun [sup.1] , Yiqin Lin [sup.1] , Zhenzhen Liu [sup.1] , Yiming Zhu [sup.1] , Qi [...]

Extant literature on the reversal of the fair process effect has demonstrated that procedural fairness can lead to adverse reactions, such as poorer self-evaluations, under circumstances of unfavorable outcomes. However, procedural fairness resulting in failure may not necessarily be bad from a developmental perspective. The present research explores the relationship between procedural fairness and participation in development activities (PDA), the underlying mechanism, and the boundary condition of the relationship, drawing on attribution theory. Data were collected from a sample of 282 employees (M.sub.age = 32.20, SD = 6.92). The results show that procedural fairness positively predicted PDA and that self-attribution mediated their relationship. In addition, self-construal played a moderating role in the relationship between self-attribution and PDA. Specifically, for individuals high in independent self-construal, self-attribution is associated with stronger PDA, while the relationship is nonsignificant for those high in interdependent self-construal. Overall, the findings shed light on the positive function of procedural fairness even under unfavorable outcomes and reveal how situational factors and individual differences may jointly shape peoples' responses to organizational events. Practical implications for how to promote PDA in organizations are also discussed., Author(s): Mike Lin [sup.1] [sup.2] , Fengxiang Zhang [sup.1] [sup.2] , Xiaomin Sun [sup.1] , Nan Zhang [sup.1] , Jiaqi Wang [sup.1] , Yanqiang Tao [sup.1] , Zhenzhen Liu [sup.1] [...]