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Drought and land salinization are inhibiting factors for the sustainable development of forestry, and the plants will release volatile substances such as terpenoids during biological or non-biological stress. The 1-hydroxy-2-methyl-2-(E)-buteny-4-pyrophosphate reductase is the terminal active enzyme of the MEP pathway, which provides precursor terpenoids and has the main rate-limiting effect. In order to investigate whether HDR gene of Pinus massoniana is involved in stress response under drought and salt stress, the open reading frame of PmHDR gene was cloned, and bioinformation, tissue specific expression and preliminary function were analyzed. The results were as follows: (1) The coding region length of PmHDR gene is 1 458 bp, encoding 485 amino acids, and its encoded protein contains the core sequence of LytB/IspH gene superfamily and PLN02821 multifunctional structural domain, which belongs to the HDR family. (2) The PmHDR codon use preference was weak, with a preference for codons ending in A/U. Nicotiana tabacum, Arabidopsis thaliana and Saccharomyces cerevisiae were more suitable as its heterologous expression receptors. (3) Results of qRT-PCR showed that the PmHDR gene was most highly expressed in old needles of Pinus massoniana, followed by young needles, young stem and old stem and least expressed in root. (4) The gene expression vector pBI121-PmHDR was constructed and transformed into Arabidopsis thaliana. The transgenic A.thaliana showed greater resistance to drought and salt stress. These results indicate that PmHDR is involved in plant response and regulation to drought and salt stress, and provide some theoretical supports for Pinus massoniana stress-resistance breeding.

Peripherally inserted central catheters (PICCs) are used as first-line central venous catheters for the delivery of chemotherapy and supportive care in cancer patients. However, PICCs-related complications, such as phlebitis, blockage, infection and allergic dermatitis may increase the level of pain and affect the following treatment. This paper summarized the nursing experience of allergic dermatitis after PICC placement in a breast cancer patient undergoing chemotherapy. Based on analyzing the relevant factors of allergic dermatitis and syndrome differentiation, timely medication, psychological intervention, dietary guidance, and other nursing interventions were carried out to relieve the local symptoms such as sitching, inflammation, rash and redness. (经外周静脉穿刺置入中心静脉导管(PICC)普遍应用于肿瘤治疗中, 但PICC相关并发症, 如静脉炎、导管堵塞、感染、过敏性皮炎等, 不仅增加患者痛苦, 还会影响患者的正常治疗。本文总结1例乳腺癌化疗患者PICC置管后并发过敏性皮炎的护理经验。护理人员积极评估皮损程度, 开展辨证施护, 通过加强皮肤护理、用药护理、心理干预、饮食指导等护理措施, 缓解局部瘙痒, 消除皮疹及红肿, 改善患者的皮肤过敏反应。)

This paper proposes a three degrees of freedom parallel anti-swing method by the main and auxiliary cables to address the problems related to underactuated double-pendulum anti-swing for a ship-mounted jib crane. By analysing the dynamic coupling relationship between the swing of the hook and the payload, it seeks to establish an accurate dynamic model of the anti-swing device under the ship’s rolling and pitching conditions, and discusses the influence of ship excitation, the crane state, load posture and anti-swing parameters on the in-plane and out-of-plane swing angles. The analysis shows that the primary pendulum reduces the in-plane angle by 90% and the out-of-plane angle by 80%, the in-plane angle of the secondary pendulum is reduced by 90%, and the out-of-plane angle is reduced by 80%. The reliability of the simulation data is verified through experiments.

This paper summarized the curative effect of manual lymphatic drainage of the breast combined with blood-pricking and cupping therapy and related nursing measures for a patient with mastitis of Qi-stagnation and Heat-congestion type. The manual lymphatic drainage of the breast was carried out under the guidance of Traditional Chinese Medicine syndrome differentiation, and then combined with the selection of Dazhui point (DV 14) and Tianzong point(SI 11) for blood-pricking and cupping therapy, so as to achieve the effect of relieving symptoms and expression of breast milk. The manual lymphatic drainage of the breast combined with blood-pricking and cupping therapy, supplemented by symptomatic nursing, can effectively alleviate the symptoms of patients and improve the treatment effect. (本文总结手法排乳联合刺络放血拔罐技术治疗1例气滞热壅型乳腺炎患者的效果和护理措施。在中医辨证指导下进行手法排乳, 再配合选取大椎穴、天宗穴行刺络放血拔罐, 从而达到症状缓解、乳汁排出通畅的效果。手法排乳联合刺络放血拔罐治疗乳腺炎, 同时辅以对症护理, 能够有效缓解患者症状, 提高治疗效果。)

As a key specialty of the hospital, the Department of Breast Diseases has one of the first Tradtitional Chinese Medicine (TCM) nursing clinics officially authorized by Beijing Administration of Traditional Chinese Medicine, and undertakes the task of clinical teaching and practice for nursing students from various colleges and universities every year. The TCM nursing clinical teaching path had been used in clinical teaching and practice, aiming to teaching the breast diseases characterized TCM nursing technology, presenting the unique characteristics of TCM, giving play to the specialty advantages, looking forward to the "integration of schools and departments" model. It is expected to provide reference for training excellent nursing talents with TCM nursing practice ability and promoting the high-quality development of TCM nursing. (医院乳腺科作为医院重点专科, 拥有北京市中医管理局首批正式授权建设的乳腺专科中医护理门诊, 每年承担各院校护生临床实习的带教任务。科室运用中医护理临床教学路径法带教, 教授乳腺科特色中医护理技术, 展现中医魅力, 发挥专科优势, 展望“院系合一”模式, 以期为培养具有中医护理实践能力的优秀护理后备人才, 推动中医护理事业高质发展提供参考。)

Objective To observe the effect of auricular acupoint sticking and pressing on postoperative pain of patients undergoing surgical treatment for granulomatous lobular mastitis (GLM). Methods Totally sixty GLM patients were randomly divided into control group and treatment group, with 30 cases in each group. All patients received routine post-operative nursing, and those in the treatment group were given auricular acupoint sticking and pressing therapy within half an hour after operation. The degree of postoperative pain was evaluated by Numerical Rating Scale(NRS) at 6 h, 24 h and 48 h after operation, and the collected data were analyzed. Results The overall rate of pain relief in the treatment group was higher than that in the control group at 24 h after surgery (83. 33% vs. 53. 33%, P＜0. 05 ). The overall rate of pain relief in the treatment group was higher than that in the control group at 48 h after surgery (93. 33% vs. 73. 33%, P＜0. 05 ). Conclusion The auricular acupoint sticking and pressing is an easy-to-operate and safe technique of Traditional Chinese Medicine, and it is effective in relief of postoperative pain in GLM patients. (目的 观察耳穴贴压治疗肉芽肿性小叶性乳腺炎术后疼痛的效果。方法 将60例肉芽肿性小叶性乳腺炎患者随机分为对照组30例和治疗组30例。两组均接受手术治疗, 对照组实施术后常规护理, 治疗组在对照组基础上, 于术后30 min内给予耳穴贴压。采用数字评分法(NRS)评估患者术后6 h、24 h和48 h疼痛程度, 评价干预效果。结果 术后24 h, 疼痛有效缓解率治疗组为83. 33%(25/30), 高于对照组的53. 33%(16/30), 差异有统计学意义(P＜0. 05)。术后48 h, 疼痛有效缓解率治疗组为93. 33%(28/30), 高于对照组的73. 33%(22/30), 差异有统计学意义(P＜0. 05)。结论 耳穴贴压能有效缓解肉芽肿性小叶性乳腺炎术后疼痛程度, 且操作简单、安全。)

This paper reviewed the clinical data of an acute mastitis patient undergoing paracentesis of breast abscess, and summarized the effect and measures of milk-ejection manipulation technique combined with external application of Rutong powder in postoperative pain relief. Nursing assessment, manipulation technique, component analysis of Rutong powder, external application methods and cautions and routine nursing intervention were summarized. Based on the Traditional Chinese Medicine nursing by syndrome differentiation, application of milk-ejection manipulation technique combined with external application of Rutong powder is effective to relief the pain of the patient after paracentesis of breast abscess. It is an effective Traditional Chinese Medicine nursing technology which helps mothers to build confidence in breastfeeding and ensure the maternal and infant safety. (本文回顾1例哺乳期急性乳腺炎脓肿形成行穿刺引流患者的临床资料, 总结手法排乳联合乳通散中药外敷缓解术后疼痛的效果及护理措施, 包括护理评估、排乳手法、乳通散组方、外敷方法和注意事项以及常规护理等。基于中医辨证施护理论指导, 采取手法排乳联合乳通散外敷治疗能够有效缓解术后疼痛, 帮助患者重拾哺乳信心, 确保母婴健康。)

This paper summarized the nursing experience of a patient with Liver-Qi stagnation and phlegm stagnation type hyperplasia of mammary glands treated by Traditional Chinese Medicine (TCM) ointment rubbing combined with moxibustion. Nursing measures and efficacy observation of TCM ointment combined with moxibustion at Zusanli acupoint were performed. In addition to the targeted interventions by TCM syndrome differentiation, health education on dietary and emotion regulation was carried to achieve the effect of dredging milk collaterals, detumescence, relieving pain and improving gland hyperplasia. (本文总结了采用中药膏摩外敷联合艾灸足三里缓解乳腺增生症状的护理经验, 包括中药膏组方选择、膏摩操作方法、艾灸足三里的注意事项以及饮食指导、情绪疏导等常规护理方法, 全程基于中医辨证指导开展针对性措施, 从而达到疏通乳络、消肿散结、缓解疼痛、改善腺体增生状态的目的。)

Objective To investigate the effect of rubbing therapy with Chinese herbal medicine ointment on pain relief in patients with hyperplasia of mammary gland. Methods Totally 40 patients suffering from pain caused by mammary gland hyperplasia were randomly divided into the control group and treatment group, with 20 cases in each group. All patients received oral administration of Chinese herbal medicine, and those in the treatment group were given rubbing therapy with Chinese herbal medicine ointment. The Numerical Rating Scale was used to evaluate the degree of pain before treatment and 14 days after treatment. Results After 14 days intervention, better pain relief was noted in the treatment group than that in the control group, with a significant difference (P＜0. 05). Conclusion The rubbing therapy with Chinese herbal medicine ointment is an easy-to-operate, safe and effective treatment on pain relief in patients with mammary gland hyperplasia. (目的 探讨乳腺中药膏摩治疗乳腺增生病疼痛的效果。方法 40例乳腺增生病患者随机分为对照组和治疗组, 各20例。对照组实施口服中药治疗, 治疗组在口服中药基础上增加乳腺中药膏摩治疗。采用数字评分法(NRS)评估患者疼痛程度, 评价干预效果。结果 干预14 d后, 疼痛干预效果治疗组优于对照组, 差异有统计学意义(P＜0. 05)。结论 中药膏摩能有效缓解乳腺增生病患者疼痛程度, 且操作简单、安全。)

This paper summarized the effect observation and nursing measures for a patient with patient with postoperative pain after granulomatous mastitis surgery under local anesthesia. On the basis of improving the routine postoperative nursing, auricular acupoint sticking and pressing therapy was carried out to relieve the postoperative pain of the patients. It has the advantages of low adverse reactions, high safety and easy acceptance by patients. (本文总结1例乳腺炎局部麻醉术后疼痛患者给予耳穴贴压治疗的效果及护理措施。在完善术后常规护理的基础上, 耳穴贴压治疗能够有效缓解患者术后疼痛, 且该方法具有不良反应小、安全性高等优势, 患者易于接受。)

This paper summarized the nursing measures for a patient with breast milk oversupply during breastfeeding treatment with intradermal needle at auricular acupoint. Key issues of nursing included nursing assessment and health education about operation method and precautions of intradermal needle at auricular acupoint. Based on the Traditional Chinese Medicine nursing by syndrome differentiation, intradermal needle at auricular acupoint is effective in relief of breast milk oversupply and establishment of maternal confidence in breastfeeding. (本文总结1例哺乳期乳汁分泌过多患者采用耳穴皮内针干预的护理经验, 包括护理评估、耳穴皮内针操作方法和注意事项以及健康宣教等。基于中医辨证施护理论指导, 采取耳穴皮内针技术, 能够有效缓解患者乳汁过多症状, 帮助患者重拾哺乳信心, 确保母婴健康。)

In order to ensure the toxic or harmful gases can be effective drainage to return air lane, this paper adopts the method of numerical simulation and uses Pyrosim simulation software to establish the actual size model of the transportation roadway, and to simulate and analyze the spread of toxic and harmful gases in the roadway when a fire occurred. The results show that when CO diffused to the leeward side, it was first detected at the height of 3.1-3.3 m. Based on this characteristic, the control sensor in the drainage system was placed at the height of the transportation lane about 3.3 m, and the detection effect was the best when the sensor was 15 cm below the vault. The core strategy of sensor control is designed for the drainage system. The PLC control device is installed in the return air diversion lane. The double CO and double smoke sensors are used to control the aluminum alloy rolling shutter air window for air flow automatic regulation. In order to ensure that the fire smoke flow is completely drained, a two-way wind speed sensor is set to assist the control, and the remote monitoring system through the wind window is used to realize the real-time monitoring and control of the workers on the shaft. Through field application, a good drainage effect has been achieved.

The continued rise in oil prices and environmental concerns have made natural gas (NG) one of the world’s most important energy sources. As populations and economies grow, the demand for natural gas is increasing due to the expansion of the industrial and commercial sectors, as well as increased household incomes. The potential for significant increases in natural gas supply to meet growing demand makes decisions at all strategic, tactical and operational levels necessary in building new or restructuring existing natural gas transportation systems. In this paper, the multi-objective optimization of natural gas hydrate (NGH) transportation is proposed as a tool for supporting regulatory decisions. Three objective functions are involved in the formulation of the problem: minimization of subsidy costs, maximization of energy utilization, and maximization of profit for each NGH plant. As part of the design parameters for the NGH project, the regulatory agency must consider the entrepreneur’s return on investment and the needs of current and future consumers. In the absence of an optimization tool, this problem may result in unfair gas prices or a lack of investor interest. With a continuous increase in natural gas consumption, the proposed analysis examines growing markets. The mixed subsidy mechanism was applied to a typical example in order to demonstrate the performance of the proposed approach.

As a means of transportation, automobiles produce large carbon emissions. On the basis of analyzing the carbon emissions of automobile transportation in 2021, the ownership model, new car sales structure model and carbon emissions analysis model are constructed, and the carbon emissions of automobiles under the baseline scenario and dual carbon scenario in 2022-2060 are predicted. For dual carbon, the main technology path of automobile can be divided into four parts: popularizing new energy vehicles, energy-saving fuel vehicles, green transportation and zero-carbon fuels.

The green tax system includes various taxation measures implemented for the purpose of environmental protection and has been widely adopted in developed countries. Based on the basic situation of China’s tax system for automobiles, this article proposes a green tax system plan for China’s automobile products from 2021 to 2035 in accordance with the basic principles of tax neutrality, environmental protection priority, tax system flexibility and orderly progress. In addition, this article uses the nested multi-logit model to predict the impact of the plan on the structure of vehicle market and finally conducts comprehensive evaluation on the environmental benefits of the plan by combining with the changes in energy consumption level, mileage of passenger vehicles, pollutant emissions of a single vehicle and other factors.

Accurate prediction of bus arrival time is essential to achieve efficient bus dispatch and improve bus trip sharing rate. This article proposes using the improved whale optimization algorithm-long short-term memory (IWOA-LSTM) model to predict bus arrival times and improving the whale algorithm by optimizing the hyperparameters of the LSTM model, so that the advantages and disadvantages of the whale algorithm and the LSTM model can complement each other, thus enhancing the robustness of the model. Initially, the bus arrival process and its associated influencing factors are analyzed, with certain factors being quantified to serve as input features for the prediction model. After processing the GPS data of the No. 220 bus in Nanchang, Jiangxi, China, the proposed prediction model is analyzed and validated using an example and compared with other prediction models. The results show that the IWOA-LSTM prediction model has the best-fitting effect between the predicted values and actual values in all time periods. Its MAPE, RMSE, and MAE have been reduced by at least 9.47%, 12.77%, and 8.93%, respectively, and the overall R[sup.2] has been improved by at least 10.65%. These results indicate that the model has the best predictive performance., Author(s): Bing Zhang (corresponding author) [1]; Lingfeng Tang [2]; Dandan Zhou [3]; Kexin Liu [4]; Yunqiang Xue [4] 1. Introduction The continuous increase in the number of motorized vehicles has [...]

Abstract Cancer is the leading cause of death worldwide. Nanomaterials and nanotechnologies could provide potential solutions. In this research, a novel biodegradable poly(lactide-co-glycolide)-d-a-tocopheryl polyethylene glycol 1000 succinate (PLGA-TPGS) random copolymer was synthesized from lactide, glycolide and d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) by ring-opening polymerization using stannous octoate as catalyst. The obtained random copolymers were characterized by 1H NMR, FTIR, GPC and TGA. The docetaxel-loaded nanoparticles made of PLGA-TPGS copolymer were prepared by a modified solvent extraction/evaporation method. The nanoparticles were then characterized by various state-of-the-art techniques. The results revealed that the size of PLGA-TPGS nanoparticles was around 250 nm. The docetaxel-loaded PLGA-TPGS nanoparticles could achieve much faster drug release in comparison with PLGA nanoparticles. In vitro cellular uptakes of such nanoparticles were investigated by CLSM, demonstrating the fluorescence PLGA-TPGS nanoparticles could be internalized by human cervix carcinoma cells (HeLa). The results also indicated that PLGA-TPGS-based nanoparticles were biocompatible, and the docetaxel-loaded PLGA-TPGS nanoparticles had significant cytotoxicity against Hela cells. The cytotoxicity against HeLa cells for PLGA-TPGS nanoparticles was in time- and concentration-dependent manner. In conclusion, PLGA-TPGS random copolymer could be acted as a novel and promising biocompatible polymeric matrix material applicable to nanoparticle-based drug delivery system for cancer chemotherapy.

Abstract Multidrug resistance (MDR) in tumor cells is a significant obstacle to the success of chemotherapy in many cancers. The purpose of this research is to test the possibility of docetaxel-loaded poly (ε-caprolactone)/Pluronic F68 (PCL/Pluronic F68) nanoparticles to overcome MDR in docetaxel-resistance human breast cancer cell line. Docetaxel-loaded nanoparticles were prepared by modified solvent displacement method using commercial PCL and self-synthesized PCL/Pluronic F68, respectively. PCL/Pluronic F68 nanoparticles were found to be of spherical shape with a rough and porous surface. The nanoparticles had an average size of around 200 nm with a narrow size distribution. The in vitro drug release profile of both nanoparticle formulations showed a biphasic release pattern. There was an increased level of uptake of PCL/Pluronic F68 nanoparticles in docetaxel-resistance human breast cancer cell line, MCF-7 TAX30, when compared with PCL nanoparticles. The cytotoxicity of PCL nanoparticles was higher than commercial Taxotere®in the MCF-7 TAX30 cell culture, but the differences were not significant (p > 0.05). However, the PCL/Pluronic F68 nanoparticles achieved significantly higher level of cytotoxicity than both of PCL nanoparticles and Taxotere®(p < 0.05), indicating docetaxel-loaded PCL/Pluronic F68 nanoparticles could overcome multidrug resistance in human breast cancer cells and therefore have considerable potential for treatment of breast cancer.