Search

Your search keyword '"LIMITE, GENNARO"' showing total 126 results
Start Over Author "LIMITE, GENNARO"
126 results on '"LIMITE, GENNARO"'

2. Adjuvant anastrozole versus exemestane versus letrozole, upfront or after 2 years of tamoxifen, in endocrine-sensitive breast cancer (FATA-GIM3): a randomised, phase 3 trial

Author

Accurso, Antonello, Agostara, Biagio, Aieta, Michele, Alabiso, Oscar, Alicicco, Maria Grazia, Amadori, Dino, Amaducci, Laura, Amiconi, Gianna, Antuzzi, Giustino, Ardine, Mara, Ardizzoia, Antonio, Aversa, Caterina, Badalamenti, Giuseppe, Barni, Sandro, Basurto, Carlo, Berardi, Rossana, Bergamasco, Cinzia, Bidoli, Paolo, Bighin, Claudia, Biondi, Edoardo, Bisagni, Giancarlo, Boni, Corrado, Borgonovo, Karen, Botta, Mario, Bravi, Stefano, Bruzzi, Paolo, Buono, Giuseppe, Butera, Alfredo, Caldara, Alessia, Candeloro, Giampiero, Cappelletti, Claudia, Cardalesi, Cinzia, Carfora, Elisabetta, Cariello, Anna, Carrozza, Francesco, Cartenì, Giacomo, Caruso, Michele, Casadei, Virginia, Casanova, Claudia, Castori, Luigi, Cavanna, Luigi, Cavazzini, Giovanna, Cazzaniga, Marina, Chilelli, Mario, Chiodini, Paolo, Chiorrini, Silvia, Ciardiello, Fortunato, Ciccarese, Mariangela, Cinieri, Saverio, Clerico, Mario, Coccaro, Mariarosa, Comande, Mario, Corbo, Claudia, Cortino, Giuseppina, Cusenza, Stefania, Daniele, Gennaro, D'arco, Alfonso Maria, D'auria, Giuliana, Dazzi, Claudio, De Angelis, Carmine, de Braud, Filippo, De Feo, Gianfranco, De Matteis, Andrea, De Tursi, Michele, Di Blasio, Anna, di Lucca, Giuseppe, Di Lullo, Liberato, Di Rella, Francesca, Di Renzo, Gianfranco, Di Stefano, Pia, Di Stefano, Aida, Diana, Anna, Donati, Sara, Fabbri, Agnese, Fabi, Alessandra, Faedi, Marina, Farina, Gabriella, Farris, Antonio, Febbraro, Antonio, Fedele, Palma, Federico, Piera, Ferraù, Francesco, Ferretti, Gianluigi, Ferro, Antonella, Floriani, Irene, Forcignanò, Rosachiara, Forciniti, Samantha, Forestieri, Valeria, Fornari, Gianni, Frisinghelli, Michela, Fusco, Vittorio, Gallizzi, Giulia, Galvano, Antonio, Gambardella, Antonio, Gambi, Angelo, Gebbia, Vittorio, Gervasi, Erika, Ghilardi, Mara, Giacobino, Alice, Giardina, Giovanni, Giotta, Francesco, Giraudi, Sara, Giuliano, Mario, Grassadonia, Antonino, Grasso, Donatella, Grosso, Federica, Guizzaro, Lorenzo, Incoronato, Pasquale, Incorvaia, Lorena, Iodice, Giovanni, La Verde, Nicla, Labonia, Vincenzo, Landi, Gabriella, Latorre, Agnese, Leonardi, Vita, Levaggi, Alessia, Limite, Gennaro, Lina Bascialla, Linda, Livi, Lorenzo, Maiello, Evaristo, Mandelli, Daniela, Marcon, Ilaria, Menon, Daniela, Montedoro, Michele, Moraca, Lucia, Moretti, Anna, Morritti, Maria Grazia, Morselli, Patrizia, Mura, Antonella, Mura, Silvia, Musacchio, Michela, Muzio, Alberto, Natale, Donato, Natoli, Clara, Nigro, Cinzia, Nisticò, Cecilia, Nuzzo, Antonio, Orditura, Michele, Orlando, Laura, Pacilio, Carmen, Palumbo, Giuliano, Palumbo, Raffaella, Pasini, Felice, Paterno, Emanuela, Pazzola, Antonio, Pelliccioni, Silvia, Pensabene, Matilde, Perroni, Davide, Pesenti Gritti, Angela, Petrelli, Fausto, Piccirillo, Maria Carmela, Pinotti, Graziella, Pogliani, Claudia, Poli, Davide, Prader, Sonia, Recchia, Francesco, Rizzi, Daniele, Romano, Carmen, Rossello, Rosalba, Rossini, Chiara, Salvucci, Giuseppina, Sanna, Valeria, Santini, Alessandra, Saracchini, Silvana, Savastano, Clementina, Scambia, Giovanni, Schettini, Francesco, Schiavone, Paola, Schirone, Alessio, Seles, Elena, Signoriello, Simona, Signoriello, Giuseppe, Silva, Rosa Rita, Silvestri, Antonia, Simeon, Vittorio, Spagnoletti, Ilaria, Tamberi, Stefano, Teragni, Cristina, Thalmann, Verena, Thomas, Renato, Thomas, Guglielmo, Tienghi, Amelia, Tinari, Nicola, Tinessa, Vincenza, Tomei, Federica, Tonini, Giuseppe, Torri, Valter, Traficante, Divina, Tudini, Marianna, Turazza, Monica, Vignoli, Roberto, Vitale, Maria Giuseppa, Zacchia, Alessandra, Zagarese, Pasquale, Zanni, Alda, Zavallone, Laura, Zavettieri, Maria, Zoboli, Alessandra, De Placido, Sabino, Gallo, Ciro, De Laurentiis, Michelino, Arpino, Grazia, Sarobba, Maria Giuseppa, Riccardi, Ferdinando, Russo, Antonio, Del Mastro, Lucia, Cogoni, Alessio Aligi, Cognetti, Francesco, Gori, Stefania, Foglietta, Jennifer, Frassoldati, Antonio, Amoroso, Domenico, Laudadio, Lucio, Moscetti, Luca, Montemurro, Filippo, Verusio, Claudio, Bernardo, Antonio, Lorusso, Vito, Gravina, Adriano, Moretti, Gabriella, Lauria, Rossella, Lai, Antonella, Mocerino, Carmela, Rizzo, Sergio, Nuzzo, Francesco, Carlini, Paolo, and Perrone, Francesco

Published
2018
Full Text
View/download PDF

12. Palbociclib added to ongoing endocrine therapy for hormone receptor‑positive HER2‑negative metastatic breast cancer: A case report series

Author

Schettini, Francesco, primary, De Santo, Irene, additional, Rea, Carmen, additional, Viggiani, Martina, additional, Buono, Giuseppe, additional, De Angelis, Carmine, additional, Cardalesi, Cinzia, additional, Lauria, Rossella, additional, Giuliano, Mario, additional, Forestieri, Valeria, additional, Thomas, Guglielmo, additional, Maione, Pierfrancesco, additional, Limite, Gennaro, additional, Accurso, Antonello, additional, Malorni, Luca, additional, De Placido, Sabino, additional, and Arpino, Grazia, additional

Published
2020
Full Text
View/download PDF

13. Therapeutic mammaplasty is a safe and effective alternative to mastectomy with or without immediate breast reconstruction

Author

Potter, S, primary, Trickey, A, additional, Rattay, T, additional, O'Connell, R L, additional, Dave, R, additional, Baker, E, additional, Whisker, L, additional, Skillman, J, additional, Gardiner, M D, additional, Macmillan, R D, additional, Holcombe, C, additional, Potter, S, additional, Barnes, Nicola L P, additional, Blazeby, Jane, additional, Conroy, Elizabeth, additional, Dave, Rajiv V, additional, Gardiner, Matthew D, additional, Harnett, Adrian, additional, Holcombe, Chris, additional, Potter, Shelley, additional, Rattay, Tim, additional, Skillman, Joanna, additional, Williamson, Paula, additional, Achuthan, Rajgopal, additional, Aggarwal, Shweta, additional, Baker, Elizabeth, additional, Basu, Naren, additional, Brock, Lisa, additional, Fairbrother, Patricia, additional, Ives, Charlotte, additional, Jain, Abhilash, additional, Kim, Baek, additional, Macmillan, R Douglas, additional, Murphy, John, additional, Remoundos, Dennis, additional, Sutton, Richard, additional, Trickey, Adam, additional, Turton, Philip, additional, Williams, Kathryn, additional, Curnier, Alain, additional, Tadros, Amir, additional, Depasquale, Ivan, additional, Fuller, Mairi, additional, Bourne, Roger, additional, Heys, Steven, additional, Hamo, Ishrak, additional, Aloraifi, Fatima, additional, Fopp, Laura, additional, Bali, Radhika, additional, Bache, Sarah, additional, Benyon, Sarah L, additional, Irwin, Michael S, additional, Agrawal, Amit, additional, Malata, Charles M, additional, Murphy, Claire, additional, Misky, Adam, additional, Chicken, Dennis Wayne, additional, Abdullah, Nassreen, additional, Hill, Arnold D K, additional, Cullinane, Carolyn, additional, Irwin, Gareth, additional, McIntosh, Stuart A, additional, Refsum, Sigi, additional, Sloan, Samantha, additional, Mallon, Peter, additional, Sirianni, Chiara, additional, Khattak, Ilyas, additional, Nagachandra, Geerthan, additional, Kiruparan, Pasupathy, additional, Debanth, Debasish, additional, Davey, Simon, additional, Curran, Terry-Ann, additional, Svenning, Matilda, additional, Govindarajulu, Sasirekha, additional, Rayter, Zenon, additional, Ainsworth, Rachel, additional, Cawthorn, Simon, additional, Sahu, Ajay, additional, Wilson, Sherif, additional, Prousskaia, Elena, additional, Accurso, Antonello, additional, Rocco, Nicola, additional, Di Micco, Rosa, additional, Limite, Gennaro, additional, Ceccarino, Raffaele, additional, Liccardo, Raffaele, additional, Coco, Guido, additional, Nizamoglu, Metin, additional, Morgan, Mary, additional, Ramakrishnan, Venkat, additional, Catanuto, Giuseppe, additional, Wilkins, Alex, additional, McManus, Penelope, additional, Kneeshaw, Peter, additional, Grover, Kartikae, additional, Mahapatra, Tapan, additional, Wooler, Brendan, additional, Elahi, Bilal, additional, Ihsan, Naila, additional, Bucknor, Alexandra, additional, Reissis, Dimitris, additional, Hunter, Judith, additional, Wood, Simon, additional, Jallali, Navid, additional, Henry, Francis P, additional, Verjee, Liaquat S, additional, Lee, Jason, additional, Khan, Shazia M, additional, Azmy, Iman, additional, Massey, Julia, additional, Hollywood, Ciaran, additional, Oluwajana, Michael, additional, Bathla, Sonia, additional, Seward, Joanna, additional, Harding-MacKean, Claudia, additional, Lane, Risha, additional, Murali, Kothandaraman, additional, Biswas, Bashishta, additional, Trapszo, Pawel, additional, Seetharam, Seema, additional, Kennedy, Katy, additional, Alder, Louise, additional, Graja, Tomasz, additional, Amin, Khalid, additional, Kokan, Jalal, additional, Roshanlall, Chandeena, additional, Gill, Emma, additional, Kulkarni, Dhananjay, additional, Dixon, J M, additional, Young, Oliver, additional, Saleem, Talha, additional, Biddle, M, additional, Kearns, Marie, additional, Weiler-Mithoff, Eva, additional, Chew, Ben, additional, Malyon, Andy, additional, Scott, John, additional, McGill, David, additional, Mackay, Iain, additional, Bains, Salena, additional, Barrows, Sara, additional, Pilgrim, Simon, additional, Shokuhi, Sheila, additional, Lambert, Kelly, additional, Kenny, Frances, additional, Valassiadou, Kalliope, additional, Kaushik, Monika, additional, Krupa, Jaroslaw, additional, Dragoumis, Dimitris, additional, Lampropoulos, Pavlos, additional, Moss, Sarah, additional, Khalil, Haitham, additional, Haq, Anwar, additional, Balasubramanian, Balapathiran, additional, Charalampoudis, Petros, additional, Hamed, Hisham, additional, Kothari, Ashutosh, additional, Kovacs, Tibor, additional, Douek, Michael, additional, Mehmood, Iftikhar, additional, Ray, Biswajit, additional, Adelekan, Matthew, additional, Humphreys, Laura, additional, Tayeh, Salim, additional, Choy, Christina, additional, Parvanta, Laila, additional, Michieletto, Silvia, additional, Saibene, Tania, additional, O'Brien, James, additional, Down, Sue, additional, Downey, Sarah, additional, Pereira, Jerome, additional, Sami, A S, additional, Gvaramadze, Anzors, additional, Jibril, Jibril A, additional, Thekkinkattil, Dinesh, additional, Udayasankar, S, additional, Khawaja, Saira, additional, Shariaha, Yousef, additional, Holt, Simon, additional, James, Ruth, additional, Rizki, Hirah, additional, Kirkpatrick, Katharine, additional, Ravichandran, Duraisamy, additional, Shrestha, Deepak, additional, Barua, Ellora, additional, Akolekar, Deepika, additional, Hamad, Ahmed, additional, Kleidi, Eleftheria, additional, Hignett, Susan, additional, Pope, Vanessa, additional, Naseem, Salma, additional, Isherwood, Jennifer, additional, Soulsby, Rachel, additional, Taylor, Amanda, additional, Chin, Kian, additional, Nguyen, Dai, additional, Guest, Francesca, additional, Thorne, Amanda, additional, Lefemine, Valentina, additional, Kirchhoff, Chris, additional, Murphy, Declan C, additional, Lo, Michelle, additional, Harcourt, Ruth, additional, Pain, Simon J, additional, Hussien, Maged I, additional, Zechmeister, Katalin, additional, Sassoon, E M, additional, Figus, Andrea, additional, Haywood, Richard M, additional, Ali, Rozina, additional, Alexander, Susanna, additional, Geropantas, Konstantinos, additional, Epurescu, Daniel, additional, Lewis, Rebecca, additional, Fafemi, Oladapo, additional, Gahir, Jasdeep, additional, Gandamihardja, Tasha, additional, Kelsall, Jennett, additional, Muhibullah, Nazli, additional, Otieno, Charlene, additional, Mazari, Fayyaz, additional, Dauria, Marta, additional, Whisker, Lisa, additional, Macmillan, Douglas, additional, Gutteridge, Eleanor, additional, Rasheed, Tuabin, additional, Khout, Hazem, additional, Asgeirsson, Kristjan, additional, McCulley, Stephen, additional, Mariniello, Maria Donatella, additional, Roncella, Manuela, additional, Ghilli, Matteo, additional, Colizzi, Livio, additional, Rossetti, Elena, additional, Marzia, Lo Russo, additional, Fustaino, Loredana, additional, Li, Alessandro Quattrini, additional, Harvey, Kate L, additional, Windle, Rebecca, additional, Remoundos, Dionysios Dennis, additional, Roy, Pankaj, additional, MacLean, Gael, additional, Adwani, Asha, additional, Popa, Elena, additional, Goh, Steven, additional, Shetty, Geeta, additional, Clark, Sarah, additional, Bernaudo, Lorenzo, additional, Agrawal, Avi, additional, Mansfield, Lucy, additional, Tebbal, Sally, additional, Patel, Ashraf, additional, Grassi, Veronica, additional, Pujji, Ojas, additional, Hamnett, Kathryn, additional, Granger, Emily, additional, Durbar, Michael, additional, Pikoulas, Panagiotis, additional, Garnsey, Clare, additional, Walker, Philip, additional, Vollermere, Angela J, additional, Michalakis, Ioannis, additional, Jones, Robin, additional, Youssef, Mina, additional, Masood, Mohammad, additional, Dunn, Julie, additional, Olsen, Sisse, additional, Ferguson, Douglas, additional, Tillett, Rachel, additional, Allan, Anna, additional, Woollard, Alex, additional, Canny, Rebecca, additional, Woollard, Alexander, additional, Mosahebi, Afshin, additional, Hamilton, Stephen, additional, Chana, Jagdeep, additional, Sojitra, Nilesh, additional, Younis, Ibby, additional, Rainsbury, Dick, additional, Chand, Natalie, additional, Kalles, Vasileios, additional, Stebbing, Anne, additional, Harris, Kevin, additional, Laws, Siobhan, additional, Tansley, Anne, additional, Mitchell, Geraldine, additional, de Sousa, Emma, additional, Henderson, Julia, additional, Chandrashekar, Mysore, additional, Pereira, Bernadette, additional, Constantinou, Chloe, additional, Elfadl, Dalia, additional, Irakleidis, Foivos, additional, Hernan, Izaro, additional, Byrne, Miriam, additional, O'Connell, Rachel, additional, Rusby, Jennifer, additional, Barry, Peter, additional, Krupa, Katerine, additional, Allum, William, additional, MacNeill, Fiona, additional, Roche, Nicola, additional, Gui, Gerald, additional, Ramsey, Kelvin, additional, Harris, Paul, additional, James, Stuart, additional, McIntosh, Jamie, additional, Laurence, Nicola, additional, MacLennan, Louise, additional, Milligan, Robert, additional, Cain, Henry, additional, Critchley, Adam, additional, O'Donoghue, Joe, additional, Kalra, Loraine, additional, Collis, Nick, additional, Weston-Petrides, Gina, additional, Fiddes, Roanne, additional, Brown, Victoria, additional, Aertssen, Anna, additional, Slade-Sharman, Diana, additional, Khan, Mansoor, additional, McGuiness, Caroline, additional, Amorosi, Vittoria, additional, di Pompeo Fabio, Santanelli, additional, Exarchos, Georgios, additional, Jiwa, Natasha, additional, Hu, Jennifer, additional, Ledwidge, Serena, additional, Johnson, Laura, additional, Peel, Anthony, additional, Dhooma, Naseem, additional, Farrell, Eric, additional, Devane, Liam, additional, Tevlin, Ruth, additional, McDermott, Enda, additional, Prichard, Ruth, additional, Evoy, Denis, additional, Rothwell, Jane, additional, Geraghty, James, additional, Morrison, Colin, additional, Lawlor, Catriona, additional, Langlands, Fiona, additional, Taylor, Lauren, additional, Achuthan, Raj, additional, Horgan, Kieran, additional, Mckenzie, Shireen, additional, Hogan, Brian, additional, Lansdown, Mark, additional, Navin, Channegowda, additional, Sherwin, Liz, additional, Mortimer, Caroline, additional, Garg, Neeraj, additional, Adam, Rahma, additional, Arif, Tahera, additional, Kryjak, Zbigniew, additional, Ali, Deedar, additional, Sowdi, Ravi, additional, Fage, Elena, additional, Mylvaganam, Senthurun, additional, Matey, Pilar, additional, Vidya, Raghavan, additional, Sircar, Tapan, additional, Asaad, Oubida, additional, Bhaskar, Pud, additional, Dordea, Matei, additional, Chrysafi, Ada, additional, McCartan, Damian, additional, Dave, Rajiv, additional, Foster, Rachel, additional, Wilson, Rebecca, additional, Okwemba, Sylvia, additional, Majeed, Yousef, additional, O'Brien, Ciara, additional, Mathen, Vinod, additional, Barnes, Nicola, additional, Gandhi, Ashu, additional, Harvey, James, additional, Kirwan, Cliona C, additional, Johnson, Richard, additional, Patel, Krupali, additional, Ribas, Maria Dalmau, additional, Vigneswaran, Natali, additional, Challoner, Tom, additional, Park, Alan, additional, Rizkalla, Maged, additional, Tomlins, Abigail, additional, McEvoy, Kat, additional, Jafferbhoy, Sadaf, additional, Soumian, Soni, additional, Narayanan, Sankaran, additional, Kirby, Robert, additional, Bajrusevic, Sladana, additional, Maalo, Joseph, additional, Charalambous, Michalis, additional, Lai, Lee Min, additional, Chong, Kelvin, additional, Thomson, Simon, additional, Monib, Sherif, additional, Chagla, Leena, additional, Audisio, Riccardo, additional, Taghizadeh, Rieka, additional, Iqbal, Azhar, additional, James, Karen, additional, Callaghan, Maria, additional, Poonawala, Shabbir, additional, Lund, Jonathan, additional, Vinayagam, Raman, additional, Thrush, Steven, additional, Thomas, Rachel Bright, additional, Mullan, Michelle, additional, Taylor, Jevan, additional, Yoshimura, Ryo, additional, Mathew, Tom, additional, Jones, Ben Mancey, additional, Munot, Kailas, additional, Nasr, Rana, additional, Piper, Jenny, additional, El-Sharief, Deena, additional, Mustafa, Mohammed, additional, MacLeod, Caitlin, additional, Smyth, Elizabeth, additional, Saeed, Nina, additional, Masannat, Yazan, additional, Mohd-Amin, Amir Tan, additional, Sloan, Sam, additional, McIntosh, Stuart, additional, Ibrahim, Abdulla, additional, Rathinaezhil, Rathi, additional, Khalifa, Eiman, additional, McManus, Penny, additional, Leeper, Alexander, additional, McIlhenny, Jennifer, additional, Mansell, James, additional, Ogsto, Keith, additional, Romics, Laszlo, additional, Shokuhi, Shelia, additional, Lee, Xiang Wei Jonathan, additional, Al-Allak, Asmaa, additional, Fowler, Clare, additional, Massey, Eleanore, additional, Court, Fiona, additional, Hunt, Richard, additional, Vestey, Sarah, additional, Elgammal, Mohsen, additional, Noshirwani, Arish, additional, Arif, Tehera, additional, Syed, Farah H, additional, Safdar, Gazalla, additional, El-Abbar, Mohammed, additional, Hogg, Fiona, additional, McGee, Pauline, additional, Pitsinis, Vassilis, additional, Smith, Jenny, additional, Makkiyah, Sundus, additional, Mustafa, Syed, additional, Photiou, Dana, additional, Gutteridge, Ellie, additional, Oni, Georgette, additional, Hallam, Kelly, additional, Asgeirron, Kristjan, additional, D'Auria, Marta, additional, Al-zubaidi, Samim, additional, Bailey, James, additional, Tenovici, Alexandra, additional, Remoundos, Dionysios-Dennis, additional, Chaidos, Nikos, additional, Predescu, Oana, additional, Rezulski, Jan, additional, Abdullah, Tholkifl, additional, Udayasankar, Sujatha, additional, Talbot, Adam, additional, Singh, Jagdeep, additional, Smith, Amy, additional, Volleamere, Angela, additional, Dean, Sarah, additional, Peiris, Lashan, additional, Sjokvist, Olivia, additional, De Sousa, Emma, additional, Micha, Aikaterini, additional, Godden, Amy, additional, Krupa, Katherine, additional, Henton, John, additional, Bennett, Ruth, additional, Nicholson, Stewart, additional, Paolini, Guido, additional, Renzi, Luca Francesco, additional, Di Pompeo, Santanelli, additional, Ria, Vitto, additional, Lewis, Rebecca S, additional, Hadad, Sirwan, additional, Sharma, Anup, additional, Toomey, Delia, additional, Banerjee, Dibyesh, additional, Tang, Sarah Shuk Kay, additional, McKenzie, Shireen, additional, Ahmad, Tanvir, additional, Williams, Kate, additional, Absar, Mohammed, additional, Nasir, Nabila, additional, Rychlik, Igor Jerzy, additional, Darragh, Lynn, additional, Johnston, Ruth, additional, Kirk, Stephen, additional, Rees-Lee, Jacqueline, additional, Green, Michael, additional, Sharma, Abhishek, additional, Choong, Jia, additional, Ullah, Zaker, additional, Koshy, Ommen, additional, Kiernan, Tamara, additional, Bhojwani, Ajay Ashok, additional, Bright-Thomas, Rachel, additional, Byrne, Ged, additional, Ibrahim, Ibrahim, additional, Highton, Lyndsey, additional, Morris, Owen, additional, Chatterjee, Sumohan, additional, Kirwan, Cliona, additional, Mancey-Jones, Ben, additional, El Sharief, Denna, additional, and Frame, Richard, additional

Published
2020
Full Text
View/download PDF

15. The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Author

O'Connell, Rachel L, Rattay, Tim, Dave, Rajiv V, Trickey, Adam, Skillman, Joanna, Barnes, Nicola LP, Gardiner, Matthew, Harnett, Adrian, Potter, Shelley, Holcombe, Chris, Blazeby, Jane, Conroy, Elizabeth, O'Brien, Ciara, Williamson, Paula, Curnier, Alain, Tadros, Amir, Depasquale, Ivan, Masannat, Yazan A, Smyth, Elizabeth, Fuller, Mairi, Bourne, Roger, Heys, Steven, Hamo, Ishrak, Aloraifi, Fatima, Fopp, Laura, Bali, Radhika, Bache, Sarah, Benyon, Sarah L, Irwin, Michael S, Agrawal, Amit, Malata, Charles M, Murphy, Claire, Misky, Adam, Chicken, Dennis Wayne, Abdullah, Nassreen, Hill, Arnold DK, Cullinane, Carolyn, Irwin, Gareth, McIntosh, Stuart A, Refsum, Sigi, Sloan, Samantha, Mallon, Peter, Sirianni, Chiara, Khattak, Ilyas, Nagachandra, Geerthan, Kiruparan, Pasupathy, Debanth, Debasish, Davey, Simon, Curran, Terry-Ann, Svenning, Matilda, Govindarajulu, Sasirekha, Rayter, Zenon, Ainsworth, Rachel, Cawthorn, Simon, Sahu, Ajay, Wilson, Sherif, Prousskaia, Elena, Accurso, Antonello, Rocco, Nicola, Di Micco, Rosa, Limite, Gennaro, Ceccarino, Raffaele, Liccardo, Raffaele, Coco, Guido, Nizamoglu, Metin, Morgan, Mary, Ramakrishnan, Venkat, Catanuto, Giuseppe, Wilkins, Alex, McManus, Penelope, Kneeshaw, Peter, Grover, Kartikae, Mahapatra, Tapan, Wooler, Brendan, Elahi, Bilal, Ihsan, Naila, Bucknor, Alexandra, Reissis, Dimitris, Hunter, Judith, Wood, Simon, Jallali, Navid, Henry, Francis P, Verjee, Liaquat S, Lee, Jason, Khan, Shazia M, Azmy, Iman, Massey, Julia, Hollywood, Ciaran, Oluwajana, Michael, Bathla, Sonia, Seward, Joanna, Harding-MacKean, Claudia, Lane, Risha, Murali, Kothandaraman, Biswas, Bashishta, Trapszo, Pawel, Seetharam, Seema, Kennedy, Katy, Alder, Louise, Graja, Tomasz, Amin, Khalid, Kokan, Jalal, Roshanlall, Chandeena, Gill, Emma, Kulkarni, Dhananjay, Dixon, JM, Young, Oliver, Saleem, Talha, Biddle, M, Kearns, Marie, Weiler-Mithoff, Eva, Chew, Ben, Malyon, Andy, Scott, John, McGill, David, Mackay, Iain, Bains, Salena, Barrows, Sara, Pilgrim, Simon, Shokuhi, Sheila, Lambert, Kelly, Kenny, Frances, Valassiadou, Kalliope, Kaushik, Monika, Krupa, Jaroslaw, Dragoumis, Dimitris, Ain, Quratul, Lampropoulos, Pavlos, Moss, Sarah, Khalil, Haitham, Haq, Anwar, Balasubramanian, Balapathiran, Charalampou-Dis, Petros, Hamed, Hisham, Kothari, Ashutosh, Kovacs, Tibor, Douek, Michael, Mehmood, Iftikhar, Ray, Biswajit, Adelekan, Matthew, Humphreys, Laura, Tayeh, Salim, Choy, Christina, Parvanta, Laila, Michieletto, Silvia, Saibene, Tania, O'Brien, James, Down, Sue, Downey, Sarah, Pereira, Jerome, Sami, AS, Gvaramadze, Anzors, Jibril, Jibril A, Thekkinkattil, Dinesh, Udayasankar, S, Khawaja, Saira, Shariaha, Yousef, Holt, Simon, James, Ruth, Rizki, Hirah, Kirkpatrick, Katharine, Ravichandran, Duraisamy, Shrestha, Deepak, Barua, Ellora, Akolekar, Deepika, Hamad, Ahmed, Kleidi, Eleftheria, Hignett, Susan, Pope, Vanessa, Naseem, Salma, Isherwood, Jennifer, Soulsby, Rachel, Taylor, Amanda, Chin, Kian, Nguyen, Dai, Guest, Francesca, Thorne, Amanda, Kirchhoff, Chris, Murphy, Declan C, Lo, Michelle, Harcourt, Ruth, Pain, Simon J, Hussien, Maged I, Zechmeister, Katalin, Sassoon, EM, Figus, Andrea, Haywood, Richard M, Ali, Rozina, Alexander, Susanna, Geropantas, Konstantinos, Epurescu, Daniel, Lewis, Rebecca, Fafemi, Oladapo, Gahir, Jasdeep, Gandamihardja, Tasha, Kelsall, Jennett, Muhibullah, Nazli, Otieno, Charlene, Mazari, Fayyaz, Dauria, Marta, Whisker, Lisa, Macmillan, Douglas, Gutteridge, Eleanor, Rasheed, Tuabin, Khout, Hazem, Asgeirsson, Kristjan, McCulley, Stephen, Mariniello, Maria Donatella, Roncella, Manuela, Ghilli, Matteo, Colizzi, Livio, Rossetti, Elena, Marzia, Lo Russo, Fustaino, Loredana, Li, Alessandro Quattrini, Harvey, Kate L, Windle, Rebecca, Remoundos, Dionysios Dennis, Roy, Pankaj, MacLean, Gael, Adwani, Asha, Popa, Elena, Goh, Steven, Shetty, Geeta, Clark, Sarah, Bernaudo, Lorenzo, Agrawal, Avi, Mansfield, Lucy, Tebbal, Sally, Patel, Ashraf, Grassi, Veronica, Pujji, Ojas, Hamnett, Kathryn, Basu, Naren, Granger, Emily, Durbar, Michael, Pikoulas, Panagiotis, Garnsey, Clare, Walker, Philip, Vollermere, Angela J, Michalakis, Ioannis, Jones, Robin, Youssef, Mina, Ives, Charlotte, Masood, Mohammad, Dunn, Julie, Olsen, Sisse, Ferguson, Douglas, Tillett, Rachel, Allan, Anna, Woollard, Alex, Canny, Rebecca, Woollard, Alexander, Mosahebi, Afshin, Hamilton, Stephen, Ghali, Shadi, Marsh, Daniel, Chana, Jagdeep, Sojitra, Nilesh, Younis, Ibby, Rainsbury, Dick, Chand, Natalie, Kalles, Vasileios, Stebbing, Anne, Harris, Kevin, Laws, Siobhan, Tansley, Anne, Mitchell, Geraldine, de Sousa, Emma, Henderson, Julia, Chandrashekar, Mysore, Pereira, Bernadette, Constantinou, Chloe, Elfadl, Dalia, Irakleidis, Foivos, Hernan, Izaro, Byrne, Miriam, To, Natalie, O'Connell, Rachel, Rusby, Jennifer, Barry, Peter, Krupa, Katerine, Allum, William, MacNeill, Fiona, Roche, Nicola, Gui, Gerald, Ramsey, Kelvin, Harris, Paul, James, Stuart, Power, Kieran, Sutton, Richard, McIntosh, Jamie, Laurence, Nicola, MacLennan, Louise, Milligan, Robert, Cain, Henry, Critchley, Adam, O'Donoghue, Joe, Kalra, Loraine, Collis, Nick, Weston-Petrides, Gina, Fiddes, Roanne, Brown, Victoria, Aertssen, Anna, Slade-Sharman, Diana, Khan, Mansoor, McGuiness, Caroline, Amorosi, Vittoria, Fabio, Santanelli di Pompeo, Exarchos, Georgios, Jiwa, Natasha, Hu, Jennifer, Ledwidge, Serena, Johnson, Laura, Peel, Anthony, Dhooma, Naseem, Farrell, Eric, Devane, Liam, Tevlin, Ruth, McDermott, Enda, Prichard, Ruth, Evoy, Denis, Rothwell, Jane, Geraghty, James, Morrison, Colin, Lawlor, Catriona, Langlands, Fiona, Taylor, Lauren, Turton, Philip, Achuthan, Raj, Horgan, Kieran, Mckenzie, Shireen, Hogan, Brian, Lansdown, Mark, Navin, Channegowda, Sherwin, Liz, Mortimer, Caroline, Garg, Neeraj, Adam, Rahma, Arif, Tahera, Kryjak, Zbigniew, Ali, Deedar, Sowdi, Ravi, Fage, Elena, Mylvaganam, Senthurun, Matey, Pilar, Vidya, Raghavan, Sircar, Tapan, Asaad, Oubida, Bhaskar, Pud, Dordea, Matei, Chrysafi, Ada, McCartan, Damian, Dave, Rajiv, Foster, Rachel, Wilson, Rebecca, Okwemba, Sylvia, Majeed, Yousef, Mathen, Vinod, Murphy, John, Barnes, Nicola, Gandhi, Ashu, Harvey, James, Kirwan, Cliona C, Johnson, Richard, Patel, Krupali, Ribas, Maria Dalmau, Vigneswaran, Natali, Challoner, Tom, Park, Alan, Rizkalla, Maged, Tomlins, Abigail, McEvoy, Kat, Jafferbhoy, Sadaf, Soumian, Soni, Narayanan, Sankaran, Kirby, Robert, Bajrusevic, Sladana, Maalo, Joseph, Charalambous, Michalis, Lai, Lee Min, Chong, Kelvin, Thomson, Simon, Monib, Sherif, Chagla, Leena, Audisio, Riccardo, Taghizadeh, Rieka, Iqbal, Azhar, James, Karen, Callaghan, Maria, Poonawala, Shabbir, Lund, Jonathan, Vinayagam, Raman, Thrush, Steven, Thomas, Rachel Bright, Mullan, Michelle, Taylor, Jevan, Yoshimura, Ryo, Mathew, Tom, Jones, Ben Mancey, Munot, Kailas, Nasr, Rana, Piper, Jenny, El-Sharief, Deena, Mustafa, Mohammed, Dumitru, Dorin, Christopoulos, Petros, O'Leary, Peter, Athanasiou, Irene, Johns, Neil, Mehta, Disha, Bibi, Saira, Syed, Farah, Koris, Jacob, Healy, Samuel, Shanks, Lindsay, Oliver, James, Bucata, Claudiu, Clarke, Natalie, Bignell, Kym, Akerlund, Malin, Brock, Lisa, Hallam, Kelly, Howes, Rachel, Armstrong, Alexander, Sethu, Claire, Zeidan, Bashar, Sjokvist, Olivia, Tasoulis, Marios, Sundaramoorthy, Souganthy, Harris, Chad, Wintrip, Dorothy, Lymperopoulos, N, Jain, Yogesh, Balata, Safa Ahmed, Grp, iBRA-2 Steering, and Collab, Breast Reconstruction Res

Subjects
Adult, Cancer Research, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Mammaplasty, trainee collaboratives, Breast Neoplasms, Article, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Breast cancer, breast cancer, Adjuvant therapy, cohort study, Medicine, Humans, Prospective Studies, Prospective cohort study, Mastectomy, Aged, Cancer, Aged, 80 and over, Manchester Cancer Research Centre, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, adjuvant therapy, immediate breast reconstruction, Middle Aged, medicine.disease, Surgery, Radiation therapy, Oncology, Centre for Surgical Research, Chemotherapy, Adjuvant, Outcomes research, 030220 oncology & carcinogenesis, Surgical oncology, Female, Breast reconstruction, business, Complication, Cohort study
Abstract

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients.

Published
2019
Full Text
View/download PDF

16. HMSH2 expression in primary breast cancer

Author

Spagnoletti, Ilaria, Pizzi, Claudia, Galietta, Annamaria, Di Maio, Massimo, Mastranzo, Paolo, Daniele, Santa, Lamberti, Maria, Limite, Gennaro, Cocozza, Sergio, Pettinato, Guido, and Contegiacomo, Alma

Published
2001

19. Adjuvant anastrozole versus exemestane versus letrozole, upfront or after 2 years of tamoxifen, in endocrine-sensitive breast cancer (FATA-GIM3): a randomised, phase 3 trial

Author

De Placido, Sabino, primary, Gallo, Ciro, additional, De Laurentiis, Michelino, additional, Bisagni, Giancarlo, additional, Arpino, Grazia, additional, Sarobba, Maria Giuseppa, additional, Riccardi, Ferdinando, additional, Russo, Antonio, additional, Del Mastro, Lucia, additional, Cogoni, Alessio Aligi, additional, Cognetti, Francesco, additional, Gori, Stefania, additional, Foglietta, Jennifer, additional, Frassoldati, Antonio, additional, Amoroso, Domenico, additional, Laudadio, Lucio, additional, Moscetti, Luca, additional, Montemurro, Filippo, additional, Verusio, Claudio, additional, Bernardo, Antonio, additional, Lorusso, Vito, additional, Gravina, Adriano, additional, Moretti, Gabriella, additional, Lauria, Rossella, additional, Lai, Antonella, additional, Mocerino, Carmela, additional, Rizzo, Sergio, additional, Nuzzo, Francesco, additional, Carlini, Paolo, additional, Perrone, Francesco, additional, Accurso, Antonello, additional, Agostara, Biagio, additional, Aieta, Michele, additional, Alabiso, Oscar, additional, Alicicco, Maria Grazia, additional, Amadori, Dino, additional, Amaducci, Laura, additional, Amiconi, Gianna, additional, Antuzzi, Giustino, additional, Ardine, Mara, additional, Ardizzoia, Antonio, additional, Aversa, Caterina, additional, Badalamenti, Giuseppe, additional, Barni, Sandro, additional, Basurto, Carlo, additional, Berardi, Rossana, additional, Bergamasco, Cinzia, additional, Bidoli, Paolo, additional, Bighin, Claudia, additional, Biondi, Edoardo, additional, Boni, Corrado, additional, Borgonovo, Karen, additional, Botta, Mario, additional, Bravi, Stefano, additional, Bruzzi, Paolo, additional, Buono, Giuseppe, additional, Butera, Alfredo, additional, Caldara, Alessia, additional, Candeloro, Giampiero, additional, Cappelletti, Claudia, additional, Cardalesi, Cinzia, additional, Carfora, Elisabetta, additional, Cariello, Anna, additional, Carrozza, Francesco, additional, Cartenì, Giacomo, additional, Caruso, Michele, additional, Casadei, Virginia, additional, Casanova, Claudia, additional, Castori, Luigi, additional, Cavanna, Luigi, additional, Cavazzini, Giovanna, additional, Cazzaniga, Marina, additional, Chilelli, Mario, additional, Chiodini, Paolo, additional, Chiorrini, Silvia, additional, Ciardiello, Fortunato, additional, Ciccarese, Mariangela, additional, Cinieri, Saverio, additional, Clerico, Mario, additional, Coccaro, Mariarosa, additional, Comande, Mario, additional, Corbo, Claudia, additional, Cortino, Giuseppina, additional, Cusenza, Stefania, additional, Daniele, Gennaro, additional, D'arco, Alfonso Maria, additional, D'auria, Giuliana, additional, Dazzi, Claudio, additional, De Angelis, Carmine, additional, de Braud, Filippo, additional, De Feo, Gianfranco, additional, De Matteis, Andrea, additional, De Tursi, Michele, additional, Di Blasio, Anna, additional, di Lucca, Giuseppe, additional, Di Lullo, Liberato, additional, Di Rella, Francesca, additional, Di Renzo, Gianfranco, additional, Di Stefano, Pia, additional, Di Stefano, Aida, additional, Diana, Anna, additional, Donati, Sara, additional, Fabbri, Agnese, additional, Fabi, Alessandra, additional, Faedi, Marina, additional, Farina, Gabriella, additional, Farris, Antonio, additional, Febbraro, Antonio, additional, Fedele, Palma, additional, Federico, Piera, additional, Ferraù, Francesco, additional, Ferretti, Gianluigi, additional, Ferro, Antonella, additional, Floriani, Irene, additional, Forcignanò, Rosachiara, additional, Forciniti, Samantha, additional, Forestieri, Valeria, additional, Fornari, Gianni, additional, Frisinghelli, Michela, additional, Fusco, Vittorio, additional, Gallizzi, Giulia, additional, Galvano, Antonio, additional, Gambardella, Antonio, additional, Gambi, Angelo, additional, Gebbia, Vittorio, additional, Gervasi, Erika, additional, Ghilardi, Mara, additional, Giacobino, Alice, additional, Giardina, Giovanni, additional, Giotta, Francesco, additional, Giraudi, Sara, additional, Giuliano, Mario, additional, Grassadonia, Antonino, additional, Grasso, Donatella, additional, Grosso, Federica, additional, Guizzaro, Lorenzo, additional, Incoronato, Pasquale, additional, Incorvaia, Lorena, additional, Iodice, Giovanni, additional, La Verde, Nicla, additional, Labonia, Vincenzo, additional, Landi, Gabriella, additional, Latorre, Agnese, additional, Leonardi, Vita, additional, Levaggi, Alessia, additional, Limite, Gennaro, additional, Lina Bascialla, Linda, additional, Livi, Lorenzo, additional, Maiello, Evaristo, additional, Mandelli, Daniela, additional, Marcon, Ilaria, additional, Menon, Daniela, additional, Montedoro, Michele, additional, Moraca, Lucia, additional, Moretti, Anna, additional, Morritti, Maria Grazia, additional, Morselli, Patrizia, additional, Mura, Antonella, additional, Mura, Silvia, additional, Musacchio, Michela, additional, Muzio, Alberto, additional, Natale, Donato, additional, Natoli, Clara, additional, Nigro, Cinzia, additional, Nisticò, Cecilia, additional, Nuzzo, Antonio, additional, Orditura, Michele, additional, Orlando, Laura, additional, Pacilio, Carmen, additional, Palumbo, Giuliano, additional, Palumbo, Raffaella, additional, Pasini, Felice, additional, Paterno, Emanuela, additional, Pazzola, Antonio, additional, Pelliccioni, Silvia, additional, Pensabene, Matilde, additional, Perroni, Davide, additional, Pesenti Gritti, Angela, additional, Petrelli, Fausto, additional, Piccirillo, Maria Carmela, additional, Pinotti, Graziella, additional, Pogliani, Claudia, additional, Poli, Davide, additional, Prader, Sonia, additional, Recchia, Francesco, additional, Rizzi, Daniele, additional, Romano, Carmen, additional, Rossello, Rosalba, additional, Rossini, Chiara, additional, Salvucci, Giuseppina, additional, Sanna, Valeria, additional, Santini, Alessandra, additional, Saracchini, Silvana, additional, Savastano, Clementina, additional, Scambia, Giovanni, additional, Schettini, Francesco, additional, Schiavone, Paola, additional, Schirone, Alessio, additional, Seles, Elena, additional, Signoriello, Simona, additional, Signoriello, Giuseppe, additional, Silva, Rosa Rita, additional, Silvestri, Antonia, additional, Simeon, Vittorio, additional, Spagnoletti, Ilaria, additional, Tamberi, Stefano, additional, Teragni, Cristina, additional, Thalmann, Verena, additional, Thomas, Renato, additional, Thomas, Guglielmo, additional, Tienghi, Amelia, additional, Tinari, Nicola, additional, Tinessa, Vincenza, additional, Tomei, Federica, additional, Tonini, Giuseppe, additional, Torri, Valter, additional, Traficante, Divina, additional, Tudini, Marianna, additional, Turazza, Monica, additional, Vignoli, Roberto, additional, Vitale, Maria Giuseppa, additional, Zacchia, Alessandra, additional, Zagarese, Pasquale, additional, Zanni, Alda, additional, Zavallone, Laura, additional, Zavettieri, Maria, additional, and Zoboli, Alessandra, additional

Published
2018
Full Text
View/download PDF

22. New Option in Non Palpable Lesions (NPLs) of the Breast: Our Experience with Mammotome® System

Author

LIMITE, GENNARO, FORMISANO, CESARE, Calabrese DP, Di Martino G, Esposito E, Farina A, Garofano G, Palma E, Villamaina E, Limite, Gennaro, Calabrese, Dp, Di Martino, G, Esposito, E, Farina, A, Garofano, G, Palma, E, Villamaina, E, and Formisano, Cesare

Abstract

Introduction: Screening mammography has allowed diagnosis of malignant lesions in preclinical stage, favouring mortality rate reduction and better conservative surgical techniques. The aim of our study is to value the accuracy of two diagnostic procedures in the management of NPLs of the breast: open biopsy and micro-histological biopsy with Mammotome. Methods: Data were collected about 182 patients with NPLs treated at our department from 2001 to 2005. 94 women (52%) received Mammotome biopsies, while 88 women (48%) were directly treated with open biopsies. 20 women of those treated with Mammotome (16 with an histological diagnosis of cancer or severe atypias and 4 with an inconclusive histology but with a suspicious mammography) were operated. Finally 108 women were surgically treated. Results: Histological findings of women at first treated with Mammotome core-biopsy and then operated revealed: 14 breast cancers, 5 fibrocystic diseases and 1 atypical ductal hyperplasia. Finally, 62 patients (34%) had a diagnosis of breast cancer. Nowaday we have noted only 3 breast cancer recurrences. Discussion: Micro-histological biopsy with Mammotome represents a valid procedure in the integrated diagnosis of NPLs of the breast and, at the same time, an efficient complement to open biopsy when there is indication for surgery.

Published
2007

24. Venous anomalies of the axilla: a single-institution experience

Author

Sollazzo, Viviana, primary, Luglio, Gaetano, additional, Esposito, Emanuela, additional, Di Micco, Rosa, additional, Giglio, Mariano Cesare, additional, Peltrini, Roberto, additional, Schettino, Pietro, additional, Amato, Bruno, additional, De Palma, Giovanni Domenico, additional, and Limite, Gennaro, additional

Published
2016
Full Text
View/download PDF

25. Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells

Author

Soprano, Maria, primary, Sorriento, Daniela, additional, Rusciano, Maria Rosaria, additional, Maione, Angela Serena, additional, Limite, Gennaro, additional, Forestieri, Pietro, additional, D’Angelo, Dario, additional, D’Alessio, Matteo, additional, Campiglia, Pietro, additional, Formisano, Pietro, additional, Iaccarino, Guido, additional, Bianco, Roberto, additional, and Illario, Maddalena, additional

Published
2016
Full Text
View/download PDF

26. Male breast cancer

Author

FORMISANO, CESARE, LIMITE, GENNARO, FORESTIERI, PIETRO, D. Calabrese, G. Di Martino, A. Farina, M. Lamberti, E. Palma, Formisano, Cesare, Limite, Gennaro, D., Calabrese, G., Di Martino, A., Farina, M., Lamberti, E., Palma, and Forestieri, Pietro

Published
2005

27. Sentinel node biopsy in early breast cancer: our first experience

Author

FORMISANO, CESARE, LIMITE, GENNARO, FORESTIERI, PIETRO, D. Calabrese, G. Di Martino, A. Farina, M. Lamberti, E. Palma, Formisano, Cesare, Limite, Gennaro, D., Calabrese, G., Di Martino, A., Farina, M., Lamberti, E., Palma, and Forestieri, Pietro

Published
2005

28. Lupus profundus: an inusual case involving the breast

Author

FORMISANO, CESARE, LIMITE, GENNARO, FORESTIERI, PIETRO, D. Calabrese, G. Di Martino, A. Farina, M. Lamberti, E. Palma, Formisano, Cesare, Limite, Gennaro, D., Calabrese, G., Di Martino, A., Farina, M., Lamberti, E., Palma, and Forestieri, Pietro

Published
2005

29. A randomised factorial trial of sequential doxorubicin and CMF vs CMF and chemotherapy alone vs chemotherapy followed by goserelin plus tamoxifen as adjuvant treatment of node-positive breast cancer

Author

DE PLACIDO, SABINO, DE LAURENTIIS, MICHELINO, LAURIA, ROSSELLA, PETRELLA, GIUSEPPE, LIMITE, GENNARO, COSTANZO, RAFFAELE, DE LENA M, LORUSSO V, PARADISO A, D'APRILE M, PISTILLUCCI G, FARRIS A, SAROBBA MG, PALAZZO S, MANZIONE L, ADAMO V, PALMERI S, FERRAU F, PAGLIARULO C, BIANCO AR, GOCSI COOPERATIVE G.R.O.U.P., DE PLACIDO, Sabino, DE LAURENTIIS, Michelino, DE LENA, M, Lorusso, V, Paradiso, A, D'Aprile, M, Pistillucci, G, Farris, A, Sarobba, Mg, Palazzo, S, Manzione, L, Adamo, V, Palmeri, S, Ferrau, F, Lauria, Rossella, Pagliarulo, C, Petrella, Giuseppe, Limite, Gennaro, Costanzo, Raffaele, Bianco, Ar, and GOCSI COOPERATIVE, G. R. O. U. P.

Abstract

The sequential doxorubicin --> CMF (CMF=cyclophosphamide, methotrexate, fluorouracil) regimen has never been compared to CMF in a randomised trial. The role of adding goserelin and tamoxifen after chemotherapy is unclear. In all, 466 premenopausal node-positive patients were randomised to: (a) CMF x 6 cycles (CMF); (b) doxorubicin x 4 cycles followed by CMF x 6 cycles (A --> CMF); (c) CMF x 6 cycles followed by goserelin plus tamoxifen x 2 years (CMF --> GT); and (d) doxorubicin x 4 cycles followed by CMF x 6 cycles followed by goserelin plus tamoxifen x 2 years (A --> CMF --> GT). The study used a 2 x 2 factorial experimental design to assess: (1) the effect of the chemotherapy regimens (CMF vs A --> CMF or arms a+c vs b+d) and (2) the effect of adding GT after chemotherapy (arms a+b vs c+d). At a median follow-up of 72 months, A --> CMF as compared to CMF significantly improved disease-free survival (DFS) with a multivariate hazard ratio (HR)=0.740 (95\% confidence interval (CI): 0.556-0.986; P=0.040) and produced a nonsignificant improvement of overall survival (OS) (HR=0.764; 95\% CI: 0.489-1.193). The addition of GT after chemotherapy significantly improved DFS (HR=0.74; 95\% CI: 0.555-0.987; P=0.040), with a nonsignificant improvement of OS (HR=0.84; 95\% CI: 0.54-1.32). A --> CMF is superior to CMF. Adding GT after chemotherapy is beneficial for premenopausal node-positive patients..

Published
2005

30. “Ductal adenocarcinoma in anular pancreas”

Author

Benassai, Giacomo, primary, Perrotta, Stefano, additional, Furino, Ermenegildo, additional, De Werra, Carlo, additional, Aloia, Sergio, additional, Del Giudice, Roberto, additional, Amato, Bruno, additional, Vigliotti, Gabriele, additional, Limite, Gennaro, additional, and Quarto, Gennaro, additional

Published
2015
Full Text
View/download PDF

31. Adjuvant therapy and outcomes in patients with stage IA breast cancer.

Author

Arpino, Grazia, primary, Giuliano, Mario, additional, De Angelis, Carmine, additional, Di Maio, Massimo, additional, Schettini, Francesco, additional, Von Arx, Claudia, additional, Riccardi, Ferdinando, additional, Palumbo, Giuliano, additional, De Laurentiis, Michelino, additional, Crispo, Anna, additional, Montella, Maurizio, additional, Grimaldi, Maria, additional, Trunfio, Martino, additional, Limite, Gennaro, additional, Accurso, Antonello, additional, and De Placido, Sabino, additional

Published
2015
Full Text
View/download PDF

32. Confocal laser endomicroscopy in breast surgery: a pilot study

Author

De Palma, Giovanni D, primary, Esposito, Dario, additional, Luglio, Gaetano, additional, Limite, Gennaro, additional, Accurso, Antonello, additional, Sollazzo, Viviana, additional, Maione, Francesco, additional, Cassese, Gianluca, additional, Siciliano, Saverio, additional, Gennarelli, Nicola, additional, Ilardi, Gennaro, additional, Paternoster, Mariano, additional, Giglio, Mariano C, additional, and Forestieri, Pietro, additional

Published
2015
Full Text
View/download PDF

34. Correction: Lobular intraepithelial neoplasia arising within breast fibroadenoma

Author

Limite, Gennaro, Esposito, Emanuela, Sollazzo, Viviana, Ciancia, Giuseppe, Formisano, Cesare, Di Micco, Rosa, De Rosa, Dario, and Forestieri, Pietro

Subjects
Medicine(all), Biochemistry, Genetics and Molecular Biology(all), ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Correction, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Published
2014

35. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials.

Author

De Laurentiis, Michele, Cancello, Giuseppe, D'Agostino, Diego, Giuliano, Mario, Giordano, Antonio, Montagna, Emilia, Lauria, Rossella, Forestieri, Valeria, Esposito, Angela, Silvestro, Lucrezia, Pennacchio, Roberta, Criscitiello, Carmen, Montanino, Agnese, Limite, Gennaro, Bianco, Angelo Raffaele, De Placido, Sabino, De Laurentiis, Michele, Cancello, Giuseppe, D'Agostino, Diego, Giuliano, Mario, Giordano, Antonio, Montagna, Emilia, Lauria, Rossella, Forestieri, Valeria, Esposito, Angela, Silvestro, Lucrezia, Pennacchio, Roberta, Criscitiello, Carmen, Montanino, Agnese, Limite, Gennaro, Bianco, Angelo Raffaele, and De Placido, Sabino

Abstract

We conducted a meta-analysis of randomized trials that evaluated the efficacy of incorporating taxanes into anthracycline-based regimens for early breast cancer (EBC). We aimed to determine whether this approach improves disease-free survival (DFS) and overall survival (OS) and whether benefits are maintained across relevant patient subgroups., Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Published
2008

39. Taxane-Based Combinations As Adjuvant Chemotherapy of Early Breast Cancer: A Meta-Analysis of Randomized Trials

Author

De Laurentiis, Michele, primary, Cancello, Giuseppe, additional, D'Agostino, Diego, additional, Giuliano, Mario, additional, Giordano, Antonio, additional, Montagna, Emilia, additional, Lauria, Rossella, additional, Forestieri, Valeria, additional, Esposito, Angela, additional, Silvestro, Lucrezia, additional, Pennacchio, Roberta, additional, Criscitiello, Carmen, additional, Montanino, Agnese, additional, Limite, Gennaro, additional, Bianco, Angelo Raffaele, additional, and De Placido, Sabino, additional

Published
2008
Full Text
View/download PDF

43. Differential TAG-72 epitope expression in breast cancer and lymph node metastases: a marker of a more aggressive phenotype

Author

Galietta, Annamaria, primary, Pizzi, Claudia, additional, Pettinato, Guido, additional, Limite, Gennaro, additional, Sgambato, Alessandro, additional, Lamberti, Maria, additional, Muraro, Raffaella, additional, Formisano, Cesare, additional, Pensabene, Matilde, additional, Bianco, Angelo, additional, Mariani-Costantini, Renato, additional, and Contegiacomo, Alma, additional

Published
2002
Full Text
View/download PDF

44. Novel deletion at codon 1254 of the BRCA1 gene in an Italian breast cancer kindred

Author

Ottini, Laura, primary, D'Amico, Cristina, additional, Noviello, Cristiana, additional, Pizzi, Claudia, additional, Pagliarulo, Clorindo, additional, Curia, Maria Cristina, additional, Limite, Gennaro, additional, Bianco, Angelo Raffaele, additional, Frati, Luigi, additional, Caramia, Felice Giacomo, additional, Cama, Alessandro, additional, Contegiacomo, Alma, additional, and Mariani-Costantini, Renato, additional

Published
1998
Full Text
View/download PDF

45. The role of MRI in predicting Ki-67 in breast cancer: preliminary results from a prospective study

Author

Viviana Sollazzo, Maria Cervotti, Gennaro Limite, Rosa Di Micco, Corrado Caiazzo, Emanuela Esposito, Pietro Forestieri, Carlo Varelli, Caiazzo, Corrado, Di Micco, Rosa, Esposito, Emanuela, Sollazzo, Viviana, Cervotti, Maria, Varelli, Carlo, Forestieri, Pietro, and Limite, Gennaro

Subjects
Adult, Cancer Research, medicine.medical_specialty, Pathology, Contrast Media, Breast Neoplasms, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, medicine, Humans, Breast, Prospective Studies, Prospective cohort study, Aged, medicine.diagnostic_test, biology, business.industry, Magnetic resonance imaging, General Medicine, Middle Aged, Prognosis, medicine.disease, Magnetic Resonance Imaging, Ki-67 Antigen, Oncology, 030220 oncology & carcinogenesis, Ki-67, biology.protein, Female, Radiology, business
Abstract

Purpose: In the last decade contrast-enhanced magnetic resonance imaging (MRI) has gained a growing role as a complementary tool for breast cancer diagnosis. Currently the relationship between the kinetic features of a breast lesion and pathologic prognostic factors has become a popular field of research. Our aim is to verify whether breast MRI could be considered a useful tool to predict Ki-67 score, thus resulting as a breast cancer prognosis indicator. Methods: From June to December 2014, we enrolled patients with breast cancer who underwent preoperative dynamic contrast-enhanced MRI at the local health agency. We analyzed the time-signal intensity curves calculating the mean values of the following parameters: the basal enhancement (Ebase), the enhancement ratio (ENHratio), the maximum enhancement (Emax), and the steepest slope of the contrast enhancement curve (Smax). Scatterplots and Pearson correlation test were used to investigate the eventual associations among these parameters. Results: A total of 27 patients underwent breast MRI during the study period. The mean ± SD Ki-67 percentage was 27.03 ± 16.8; the mean Emax, Smax, Ebase, and ENHratio were 433.9 ± 120.2, 267.3 ± 96.8, 165.5 ± 77.1, and 187.1 ± 94.8, respectively. Scatterplots suggest a positive correlation between Ki-67 and both Emax and Smax. The correlation tests between Ki-67 and Emax, Ki-67 and Smax showed statistical significance. Conclusions: Our preliminary data suggest that enhancement pattern is closely linked to breast cancer proliferation, thus proving the relationship between more proliferating tumors and more rapidly enhanced lesions. This is hypothesis-generating for further studies aimed at promoting breast MRI in the early estimation of cancer prognosis and tumor in vivo response to chemotherapy.

Published
2018
Full Text
View/download PDF

46. Venous anomalies of the axilla: a single-institution experience

Author

Gennaro Limite, Pietro Schettino, Giovanni Domenico De Palma, Bruno Amato, Emanuela Esposito, Mariano Cesare Giglio, Gaetano Luglio, Viviana Sollazzo, Roberto Peltrini, Rosa Di Micco, Sollazzo, Viviana, Luglio, Gaetano, Esposito, Emanuela, DI MICCO, Rosa, Giglio, MARIANO CESARE, Peltrini, Roberto, Schettino, Pietro, Amato, Bruno, DE PALMA, GIOVANNI DOMENICO, and Limite, Gennaro

Subjects
Aging, medicine.medical_specialty, Intraoperative Complication, Vascular Malformations, Breast Neoplasms, Axillary dissection, 030230 surgery, Vascular variation, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, medicine, Axillary anatomy, Humans, Prospective Studies, Axillary Vein, Intraoperative Complications, Lymph node, Mastectomy, Aged, Neoplasm Staging, business.industry, Lymphatic Metastasi, Middle Aged, Vascular System Injuries, medicine.disease, Surgery, Prospective Studie, Axilla, Dissection, medicine.anatomical_structure, Angular vein, medicine.vein, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Lymph Node Excision, Female, Axillary Dissection, Geriatrics and Gerontology, business, Axillary vein, Vascular System Injurie, Breast Neoplasm, Human, Lateral thoracic vein
Abstract

Surgical treatment is still the cornerstone in the treatment of breast cancer, a very common neoplasia, particularly affecting the female elderly population. Axillary dissection is crucial in the treatment of some tumours, but variations in axillary vessels anatomy are poorly described in standard anatomy and surgical textbook. We aimed to describe anatomical variations in axillary vessels found in our institutional experience. A prospective 3-year study was conducted in our institution from January 2012 to December 2014. Sixty-one consecutive axillary lymph node dissections (ALNDs) were performed in 61 patients who underwent surgery for stage II and III invasive breast cancer. Anatomical details of axillary vascular anatomy and its variations have been evaluated, described and stored in a prospective database. Sixty-one ALNDs have been performed in the study period. The anatomy of lateral thoracic vein, angular vein and axillary vein was studied and compared with standard anatomical description. Eighteen percentage of venous variations were found out of the 61 dissection performed. Vascular anatomy of axilla is complex and variable. A better knowledge of all possible variations might be helpful in preventing injuries during ALND.

Published
2016
Full Text
View/download PDF

47. Can axillary node dissection be safely omitted in the elderly? A retrospective study on axillary management of early breast cancer in older women

Author

Gaetano Luglio, Giacomo Benassai, Bruno Amato, Emanuela Esposito, Vincenzo Desiato, S. Perrotta, Maria Cervotti, Gennaro Limite, Rosa Di Micco, Viviana Sollazzo, Pietro Forestieri, Pasquale Mozzillo, Esposito, Emanuela, Sollazzo, Viviana, DI MICCO, Rosa, Cervotti, Maria, Luglio, Gaetano, Benassai, Giacomo, Mozzillo, Pasquale, Perrotta, Stefano, Desiato, Vincenzo, Amato, Bruno, Forestieri, Pietro, and Limite, Gennaro

Subjects
medicine.medical_specialty, Health Services for the Aged, Lymphovascular invasion, Sentinel lymph node, Breast Neoplasms, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, medicine, Humans, 030212 general & internal medicine, Stage (cooking), Macrometastasis, Lymph node, Aged, Neoplasm Staging, Retrospective Studies, Sentinel node biopsy, Sentinel Lymph Node Biopsy, business.industry, Micrometastasis, Early breast cancer, Axillary Lymph Node Dissection, General Medicine, Surgery, Axilla, medicine.anatomical_structure, Italy, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Micrometastase, Female, Neoplasm Recurrence, Local, business
Abstract

Sentinel lymph node biopsy (SLNB) is a minimally invasive technique to stage the axillary lymph node status. The burden of nodal metastasis is of great concern, as the clinical relevance and therapeutic implications of pN1mi and pN0(i+) in the sentinel lymph node (SLN) remain a matter of debate.We examined the pathological features of 901 patients above the age of 65 presenting with clinical T1-T2 N0M0 breast tumours (3 cm), detecting tumours related to llary non-sentinel node (NSN) metastases when the SLN was minimally involved.A total of 270 patients underwent complete axillary lymph node dissection (cALND) after their SLNB specimen tested positive for macrometastasis, micrometastasis and isolated tumour cells (ITCs). Seventy-six patients were diagnosed with micrometastatic disease pN1mi (27.5%), whilst ITCs (pN0i+) were detected in seven patients (2.5%). NSNs were found to be involved in two patients (2.6%) with micrometastases at the SLN. No further metastatic disease was detected in NSNs when the SLN contained ITCs. At a median follow-up period of 5.8 years, no axillary recurrence was observed among pN1mi and pN0(i+) patients. Lobular histotype, multicentricity and lymphovascular invasion were found to be associated with NSN involvement.The results from our case series are supported by IBCSG 23-01 level 1 evidence, which demonstrated a local recurrence rate of 1% in 'minimally involved not-surgical treated axilla'.Based on current evidence, we spare well-informed and consenting patients from further axillary surgery when the SLN is minimally involved in early breast cancer within an agreed protocol, whilst scheduling adjuvant treatment based on the patients' primary tumour characteristics.

Published
2016
Full Text
View/download PDF

48. Adjuvant anastrozole versus exemestane versus letrozole, upfront or after 2 years of tamoxifen, in endocrine-sensitive breast cancer (FATA-GIM3): a randomised, phase 3 trial

Author

Sabino De Placido, Ciro Gallo, Michelino De Laurentiis, Giancarlo Bisagni, Grazia Arpino, Maria Giuseppa Sarobba, Ferdinando Riccardi, Antonio Russo, Lucia Del Mastro, Alessio Aligi Cogoni, Francesco Cognetti, Stefania Gori, Jennifer Foglietta, Antonio Frassoldati, Domenico Amoroso, Lucio Laudadio, Luca Moscetti, Filippo Montemurro, Claudio Verusio, Antonio Bernardo, Vito Lorusso, Adriano Gravina, Gabriella Moretti, Rossella Lauria, Antonella Lai, Carmela Mocerino, Sergio Rizzo, Francesco Nuzzo, Paolo Carlini, Francesco Perrone, Antonello Accurso, Biagio Agostara, Michele Aieta, Oscar Alabiso, Maria Grazia Alicicco, Dino Amadori, Laura Amaducci, Gianna Amiconi, Giustino Antuzzi, Mara Ardine, Antonio Ardizzoia, Caterina Aversa, Giuseppe Badalamenti, Sandro Barni, Carlo Basurto, Rossana Berardi, Cinzia Bergamasco, Paolo Bidoli, Claudia Bighin, Edoardo Biondi, Corrado Boni, Karen Borgonovo, Mario Botta, Stefano Bravi, Paolo Bruzzi, Giuseppe Buono, Alfredo Butera, Alessia Caldara, Giampiero Candeloro, Claudia Cappelletti, Cinzia Cardalesi, Elisabetta Carfora, Anna Cariello, Francesco Carrozza, Giacomo Cartenì, Michele Caruso, Virginia Casadei, Claudia Casanova, Luigi Castori, Luigi Cavanna, Giovanna Cavazzini, Marina Cazzaniga, Mario Chilelli, Paolo Chiodini, Silvia Chiorrini, Fortunato Ciardiello, Mariangela Ciccarese, Saverio Cinieri, Mario Clerico, Mariarosa Coccaro, Mario Comande, Claudia Corbo, Giuseppina Cortino, Stefania Cusenza, Gennaro Daniele, Alfonso Maria D'arco, Giuliana D'auria, Claudio Dazzi, Carmine De Angelis, Filippo de Braud, Gianfranco De Feo, Andrea De Matteis, Michele De Tursi, Anna Di Blasio, Giuseppe di Lucca, Liberato Di Lullo, Francesca Di Rella, Gianfranco Di Renzo, Pia Di Stefano, Aida Di Stefano, Anna Diana, Sara Donati, Agnese Fabbri, Alessandra Fabi, Marina Faedi, Gabriella Farina, Antonio Farris, Antonio Febbraro, Palma Fedele, Piera Federico, Francesco Ferraù, Gianluigi Ferretti, Antonella Ferro, Irene Floriani, Rosachiara Forcignanò, Samantha Forciniti, Valeria Forestieri, Gianni Fornari, Michela Frisinghelli, Vittorio Fusco, Giulia Gallizzi, Antonio Galvano, Antonio Gambardella, Angelo Gambi, Vittorio Gebbia, Erika Gervasi, Mara Ghilardi, Alice Giacobino, Giovanni Giardina, Francesco Giotta, Sara Giraudi, Mario Giuliano, Antonino Grassadonia, Donatella Grasso, Federica Grosso, Lorenzo Guizzaro, Pasquale Incoronato, Lorena Incorvaia, Giovanni Iodice, Nicla La Verde, Vincenzo Labonia, Gabriella Landi, Agnese Latorre, Vita Leonardi, Alessia Levaggi, Gennaro Limite, Linda Lina Bascialla, Lorenzo Livi, Evaristo Maiello, Daniela Mandelli, Ilaria Marcon, Daniela Menon, Michele Montedoro, Lucia Moraca, Anna Moretti, Maria Grazia Morritti, Patrizia Morselli, Antonella Mura, Silvia Mura, Michela Musacchio, Alberto Muzio, Donato Natale, Clara Natoli, Cinzia Nigro, Cecilia Nisticò, Antonio Nuzzo, Michele Orditura, Laura Orlando, Carmen Pacilio, Giuliano Palumbo, Raffaella Palumbo, Felice Pasini, Emanuela Paterno, Antonio Pazzola, Silvia Pelliccioni, Matilde Pensabene, Davide Perroni, Angela Pesenti Gritti, Fausto Petrelli, Maria Carmela Piccirillo, Graziella Pinotti, Claudia Pogliani, Davide Poli, Sonia Prader, Francesco Recchia, Daniele Rizzi, Carmen Romano, Rosalba Rossello, Chiara Rossini, Giuseppina Salvucci, Valeria Sanna, Alessandra Santini, Silvana Saracchini, Clementina Savastano, Giovanni Scambia, Francesco Schettini, Paola Schiavone, Alessio Schirone, Elena Seles, Simona Signoriello, Giuseppe Signoriello, Rosa Rita Silva, Antonia Silvestri, Vittorio Simeon, Ilaria Spagnoletti, Stefano Tamberi, Cristina Teragni, Verena Thalmann, Renato Thomas, Guglielmo Thomas, Amelia Tienghi, Nicola Tinari, Vincenza Tinessa, Federica Tomei, Giuseppe Tonini, Valter Torri, Divina Traficante, Marianna Tudini, Monica Turazza, Roberto Vignoli, Maria Giuseppa Vitale, Alessandra Zacchia, Pasquale Zagarese, Alda Zanni, Laura Zavallone, Maria Zavettieri, Alessandra Zoboli, De Placido, S., Gallo, C., De Laurentiis, M., Bisagni, G., Arpino, G., Sarobba, M. G., Riccardi, F., Russo, A., Del Mastro, L., Cogoni, A. A., Cognetti, F., Gori, S., Foglietta, J., Frassoldati, A., Amoroso, D., Laudadio, L., Moscetti, L., Montemurro, F., Verusio, C., Bernardo, A., Lorusso, V., Gravina, A., Moretti, G., Lauria, R., Lai, A., Mocerino, C., Rizzo, S., Nuzzo, F., Carlini, P., Perrone, F., Accurso, A., Agostara, B., Aieta, M., Alabiso, O., Alicicco, M. G., Amadori, D., Amaducci, L., Amiconi, G., Antuzzi, G., Ardine, M., Ardizzoia, A., Aversa, C., Badalamenti, G., Barni, S., Basurto, C., Berardi, R., Bergamasco, C., Bidoli, P., Bighin, C., Biondi, E., Boni, C., Borgonovo, K., Botta, M., Bravi, S., Bruzzi, P., Buono, G., Butera, A., Caldara, A., Candeloro, G., Cappelletti, C., Cardalesi, C., Carfora, E., Cariello, A., Carrozza, F., Carteni, G., Caruso, M., Casadei, V., Casanova, C., Castori, L., Cavanna, L., Cavazzini, G., Cazzaniga, M., Chilelli, M., Chiodini, P., Chiorrini, S., Ciardiello, F., Ciccarese, M., Cinieri, S., Clerico, M., Coccaro, M., Comande, M., Corbo, C., Cortino, G., Cusenza, S., Daniele, G., D'Arco, A. M., D'Auria, G., Dazzi, C., De Angelis, C., de Braud, F., De Feo, G., De Matteis, Ma., De Tursi, M., Di Blasio, A., di Lucca, G., Di Lullo, L., Di Rella, F., Di Renzo, G., Di Stefano, P., Di Stefano, A., Diana, A., Donati, S., Fabbri, A., Fabi, A., Faedi, M., Farina, G., Farris, A., Febbraro, A., Fedele, P., Federico, P., Ferrau, F., Ferretti, G., Ferro, A., Floriani, I., Forcignano, R., Forciniti, S., Forestieri, V., Fornari, G., Frisinghelli, M., Fusco, V., Gallizzi, G., Galvano, A., Gambardella, A., Gambi, A., Gebbia, V., Gervasi, E., Ghilardi, M., Giacobino, A., Giardina, G., Giotta, F., Giraudi, S., Giuliano, M., Grassadonia, A., Grasso, D., Grosso, F., Guizzaro, L., Incoronato, P., Incorvaia, L., Iodice, G., La Verde, N., Labonia, V., Landi, G., Latorre, A., Leonardi, V., Levaggi, A., Limite, G., Lina Bascialla, L., Livi, L., Maiello, E., Mandelli, D., Marcon, I., Menon, D., Montedoro, M., Moraca, L., Moretti, A., Morritti, M. G., Morselli, P., Mura, A., Mura, S., Musacchio, M., Muzio, A., Natale, D., Natoli, C., Nigro, C., Nistico, C., Nuzzo, A., Orditura, M., Orlando, L., Pacilio, C., Palumbo, G., Palumbo, R., Pasini, F., Paterno, E., Pazzola, A., Pelliccioni, S., Pensabene, M., Perroni, D., Pesenti Gritti, A., Petrelli, F., Piccirillo, M. C., Pinotti, G., Pogliani, C., Poli, D., Prader, S., Recchia, F., Rizzi, D., Romano, C., Rossello, R., Rossini, C., Salvucci, G., Sanna, V., Santini, A., Saracchini, S., Savastano, C., Scambia, G., Schettini, F., Schiavone, P., Schirone, A., Seles, E., Signoriello, S., Signoriello, G., Silva, R. R., Silvestri, A., Simeon, V., Spagnoletti, I., Tamberi, S., Teragni, C., Thalmann, V., Thomas, R., Thomas, G., Tienghi, A., Tinari, N., Tinessa, V., Tomei, F., Tonini, G., Torri, V., Traficante, D., Tudini, M., Turazza, M., Vignoli, R., Vitale, M. G., Zacchia, A., Zagarese, P., Zanni, A., Zavallone, L., Zavettieri, M., Zoboli, A., De Placido, Sabino, Gallo, Ciro, De Laurentiis, Michelino, Bisagni, Giancarlo, Arpino, Grazia, Sarobba, Maria Giuseppa, Riccardi, Ferdinando, Russo, Antonio, Del Mastro, Lucia, Cogoni, Alessio Aligi, Cognetti, Francesco, Gori, Stefania, Foglietta, Jennifer, Frassoldati, Antonio, Amoroso, Domenico, Laudadio, Lucio, Moscetti, Luca, Montemurro, Filippo, Verusio, Claudio, Bernardo, Antonio, Lorusso, Vito, Gravina, Adriano, Moretti, Gabriella, Lauria, Rossella, Lai, Antonella, Mocerino, Carmen, Rizzo, Sergio, Nuzzo, Francesco, Carlini, Paolo, Perrone, Francesco, Accurso, Antonello, Agostara, Biagio, Aieta, Michele, Alabiso, Oscar, Alicicco, Maria Grazia, Amadori, Dino, Amaducci, Laura, Amiconi, Gianna, Antuzzi, Giustino, Ardine, Mara, Ardizzoia, Antonio, Aversa, Caterina, Badalamenti, Giuseppe, Barni, Sandro, Basurto, Carlo, Berardi, Rossana, Bergamasco, Cinzia, Bidoli, Paolo, Bighin, Claudia, Biondi, Edoardo, Boni, Corrado, Borgonovo, Karen, Botta, Mario, Bravi, Stefano, Bruzzi, Paolo, Buono, Giuseppe, Butera, Alfredo, Caldara, Alessia, Candeloro, Giampiero, Cappelletti, Claudia, Cardalesi, Cinzia, Carfora, Elisabetta, Cariello, Anna, Carrozza, Francesco, Cartenì, Giacomo, Caruso, Michele, Casadei, Virginia, Casanova, Claudia, Castori, Luigi, Cavanna, Luigi, Cavazzini, Giovanna, Cazzaniga, Marina, Chilelli, Mario, Chiodini, Paolo, Chiorrini, Silvia, Ciardiello, Fortunato, Ciccarese, Mariangela, Cinieri, Saverio, Clerico, Mario, Coccaro, Mariarosa, Comande, Mario, Corbo, Claudia, Cortino, Giuseppina, Cusenza, Stefania, Daniele, Gennaro, D'arco, Alfonso Maria, D'auria, Giuliana, Dazzi, Claudio, De Angelis, Carmine, de Braud, Filippo, De Feo, Gianfranco, De Matteis, Andrea, De Tursi, Michele, Di Blasio, Anna, di Lucca, Giuseppe, Di Lullo, Liberato, Di Rella, Francesca, Di Renzo, Gianfranco, Di Stefano, Pia, Di Stefano, Aida, Diana, Anna, Donati, Sara, Fabbri, Agnese, Fabi, Alessandra, Faedi, Marina, Farina, Gabriella, Farris, Antonio, Febbraro, Antonio, Fedele, Palma, Federico, Piera, Ferraù, Francesco, Ferretti, Gianluigi, Ferro, Antonella, Floriani, Irene, Forcignanò, Rosachiara, Forciniti, Samantha, Forestieri, Valeria, Fornari, Gianni, Frisinghelli, Michela, Fusco, Vittorio, Gallizzi, Giulia, Galvano, Antonio, Gambardella, Antonio, Gambi, Angelo, Gebbia, Vittorio, Gervasi, Erika, Ghilardi, Mara, Giacobino, Alice, Giardina, Giovanni, Giotta, Francesco, Giraudi, Sara, Giuliano, Mario, Grassadonia, Antonino, Grasso, Donatella, Grosso, Federica, Guizzaro, Lorenzo, Incoronato, Pasquale, Incorvaia, Lorena, Iodice, Giovanni, La Verde, Nicla, Labonia, Vincenzo, Landi, Gabriella, Latorre, Agnese, Leonardi, Vita, Levaggi, Alessia, Limite, Gennaro, Lina Bascialla, Linda, Livi, Lorenzo, Maiello, Evaristo, Mandelli, Daniela, Marcon, Ilaria, Menon, Daniela, Montedoro, Michele, Moraca, Lucia, Moretti, Anna, Morritti, Maria Grazia, Morselli, Patrizia, Mura, Antonella, Mura, Silvia, Musacchio, Michela, Muzio, Alberto, Natale, Donato, Natoli, Clara, Nigro, Cinzia, Nisticò, Cecilia, Nuzzo, Antonio, Orditura, Michele, Orlando, Laura, Pacilio, Carmen, Palumbo, Giuliano, Palumbo, Raffaella, Pasini, Felice, Paterno, Emanuela, Pazzola, Antonio, Pelliccioni, Silvia, Pensabene, Matilde, Perroni, Davide, Pesenti Gritti, Angela, Petrelli, Fausto, Piccirillo, Maria Carmela, Pinotti, Graziella, Pogliani, Claudia, Poli, Davide, Prader, Sonia, Recchia, Francesco, Rizzi, Daniele, Romano, Carmen, Rossello, Rosalba, Rossini, Chiara, Salvucci, Giuseppina, Sanna, Valeria, Santini, Alessandra, Saracchini, Silvana, Savastano, Clementina, Scambia, Giovanni, Schettini, Francesco, Schiavone, Paola, Schirone, Alessio, Seles, Elena, Signoriello, Simona, Signoriello, Giuseppe, Silva, Rosa Rita, Silvestri, Antonia, Simeon, Vittorio, Spagnoletti, Ilaria, Tamberi, Stefano, Teragni, Cristina, Thalmann, Verena, Thomas, Renato, Thomas, Guglielmo, Tienghi, Amelia, Tinari, Nicola, Tinessa, Vincenza, Tomei, Federica, Tonini, Giuseppe, Torri, Valter, Traficante, Divina, Tudini, Marianna, Turazza, Monica, Vignoli, Roberto, Vitale, Maria Giuseppa, Zacchia, Alessandra, Zagarese, Pasquale, Zanni, Alda, Zavallone, Laura, Zavettieri, Maria, Zoboli, Alessandra, Mocerino, Carmela, D'Arco, Alfonso Maria, D'Auria, Giuliana, De Placido, S, Gallo, C, De Laurentiis, M, Bisagni, G, Arpino, G, Sarobba, M, Riccardi, F, Russo, A, Del Mastro, L, Cogoni, A, Cognetti, F, Gori, S, Foglietta, J, Frassoldati, A, Amoroso, D, Laudadio, L, Moscetti, L, Montemurro, F, Verusio, C, Bernardo, A, Lorusso, V, Gravina, A, Moretti, G, Lauria, R, Lai, A, Mocerino, C, Rizzo, S, Nuzzo, F, Carlini, P, Perrone, F, Accurso, A, Agostara, B, Aieta, M, Alabiso, O, Alicicco, M, Amadori, D, Amaducci, L, Amiconi, G, Antuzzi, G, Ardine, M, Ardizzoia, A, Aversa, C, Badalamenti, G, Barni, S, Basurto, C, Berardi, R, Bergamasco, C, Bidoli, P, Bighin, C, Biondi, E, Boni, C, Borgonovo, K, Botta, M, Bravi, S, Bruzzi, P, Buono, G, Butera, A, Caldara, A, Candeloro, G, Cappelletti, C, Cardalesi, C, Carfora, E, Cariello, A, Carrozza, F, Carteni, G, Caruso, M, Casadei, V, Casanova, C, Castori, L, Cavanna, L, Cavazzini, G, Cazzaniga, M, Chilelli, M, Chiodini, P, Chiorrini, S, Ciardiello, F, Ciccarese, M, Cinieri, S, Clerico, M, Coccaro, M, Comande, M, Corbo, C, Cortino, G, Cusenza, S, Daniele, G, D'Arco, A, D'Auria, G, Dazzi, C, De Angelis, C, de Braud, F, De Feo, G, De Matteis, A, De Tursi, M, Di Blasio, A, di Lucca, G, Di Lullo, L, Di Rella, F, Di Renzo, G, Di Stefano, P, Di Stefano, A, Diana, A, Donati, S, Fabbri, A, Fabi, A, Faedi, M, Farina, G, Farris, A, Febbraro, A, Fedele, P, Federico, P, Ferrau, F, Ferretti, G, Ferro, A, Floriani, I, Forcignano, R, Forciniti, S, Forestieri, V, Fornari, G, Frisinghelli, M, Fusco, V, Gallizzi, G, Galvano, A, Gambardella, A, Gambi, A, Gebbia, V, Gervasi, E, Ghilardi, M, Giacobino, A, Giardina, G, Giotta, F, Giraudi, S, Giuliano, M, Grassadonia, A, Grasso, D, Grosso, F, Guizzaro, L, Incoronato, P, Incorvaia, L, Iodice, G, La Verde, N, Labonia, V, Landi, G, Latorre, A, Leonardi, V, Levaggi, A, Limite, G, Lina Bascialla, L, Livi, L, Maiello, E, Mandelli, D, Marcon, I, Menon, D, Montedoro, M, Moraca, L, Moretti, A, Morritti, M, Morselli, P, Mura, A, Mura, S, Musacchio, M, Muzio, A, Natale, D, Natoli, C, Nigro, C, Nistico, C, Nuzzo, A, Orditura, M, Orlando, L, Pacilio, C, Palumbo, G, Palumbo, R, Pasini, F, Paterno, E, Pazzola, A, Pelliccioni, S, Pensabene, M, Perroni, D, Pesenti Gritti, A, Petrelli, F, Piccirillo, M, Pinotti, G, Pogliani, C, Poli, D, Prader, S, Recchia, F, Rizzi, D, Romano, C, Rossello, R, Rossini, C, Salvucci, G, Sanna, V, Santini, A, Saracchini, S, Savastano, C, Scambia, G, Schettini, F, Schiavone, P, Schirone, A, Seles, E, Signoriello, S, Signoriello, G, Silva, R, Silvestri, A, Simeon, V, Spagnoletti, I, Tamberi, S, Teragni, C, Thalmann, V, Thomas, R, Thomas, G, Tienghi, A, Tinari, N, Tinessa, V, Tomei, F, Tonini, G, Torri, V, Traficante, D, Tudini, M, Turazza, M, Vignoli, R, Vitale, M, Zacchia, A, Zagarese, P, Zanni, A, Zavallone, L, Zavettieri, M, and Zoboli, A

Subjects
Oncology, Receptor, ErbB-2, Settore MED/06 - Oncologia Medica, letrozole, law.invention, Adjuvant anastrozole, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, Exemestane, law, exemestane, tamoxifen, breast cancer, Antineoplastic Combined Chemotherapy Protocols, 030212 general & internal medicine, Aromatase Inhibitors, Letrozole, Hazard ratio, Middle Aged, Receptors, Estrogen, Tolerability, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Female, Receptors, Progesterone, Breast Neoplasm, Human, medicine.drug, medicine.medical_specialty, Socio-culturale, Anastrozole, Breast Neoplasms, Disease-Free Survival, Drug Administration Schedule, 03 medical and health sciences, Breast cancer, Internal medicine, medicine, Aromatase Inhibitor, Humans, Aged, Antineoplastic Combined Chemotherapy Protocol, Androstadiene, business.industry, medicine.disease, Androstadienes, chemistry, business, Tamoxifen
Abstract

Background: Uncertainty exists about the optimal schedule of adjuvant treatment of breast cancer with aromatase inhibitors and, to our knowledge, no trial has directly compared the three aromatase inhibitors anastrozole, exemestane, and letrozole. We investigated the schedule and type of aromatase inhibitors to be used as adjuvant treatment for hormone receptor-positive early breast cancer. Methods: FATA-GIM3 is a multicentre, open-label, randomised, phase 3 trial of six different treatments in postmenopausal women with hormone receptor-positive early breast cancer. Eligible patients had histologically confirmed invasive hormone receptor-positive breast cancer that had been completely removed by surgery, any pathological tumour size, and axillary nodal status. Key exclusion criteria were hormone replacement therapy, recurrent or metastatic disease, previous treatment with tamoxifen, and another malignancy in the previous 10 years. Patients were randomly assigned in an equal ratio to one of six treatment groups: oral anastrozole (1 mg per day), exemestane (25 mg per day), or letrozole (2·5 mg per day) tablets upfront for 5 years (upfront strategy) or oral tamoxifen (20 mg per day) for 2 years followed by oral administration of one of the three aromatase inhibitors for 3 years (switch strategy). Randomisation was done by a computerised minimisation procedure stratified for oestrogen receptor, progesterone receptor, and HER2 status; previous chemotherapy; and pathological nodal status. Neither the patients nor the physicians were masked to treatment allocation. The primary endpoint was disease-free survival. The minimum cutoff to declare superiority of the upfront strategy over the switch strategy was assumed to be a 2% difference in disease-free survival at 5 years. Primary efficacy analyses were done by intention to treat; safety analyses included all patients for whom at least one safety case report form had been completed. Follow-up is ongoing. This trial is registered with the European Clinical Trials Database, number 2006-004018-42, and ClinicalTrials.gov, number NCT00541086. Findings: Between March 9, 2007, and July 31, 2012, 3697 patients were enrolled into the study. After a median follow-up of 60 months (IQR 46–72), 401 disease-free survival events were reported, including 211 (11%) of 1850 patients allocated to the switch strategy and 190 (10%) of 1847 patients allocated to upfront treatment. 5-year disease-free survival was 88·5% (95% CI 86·7–90·0) with the switch strategy and 89·8% (88·2–91·2) with upfront treatment (hazard ratio 0·89, 95% CI 0·73–1·08; p=0·23). 5-year disease-free survival was 90·0% (95% CI 87·9–91·7) with anastrozole (124 events), 88·0% (85·8–89·9) with exemestane (148 events), and 89·4% (87·3 to 91·1) with letrozole (129 events; p=0·24). No unexpected serious adverse reactions or treatment-related deaths occurred. Musculoskeletal side-effects were the most frequent grade 3–4 events, reported in 130 (7%) of 1761 patients who received the switch strategy and 128 (7%) of 1766 patients who received upfront treatment. Grade 1 musculoskeletal events were more frequent with the upfront schedule than with the switch schedule (924 [52%] of 1766 patients vs 745 [42%] of 1761 patients). All other grade 3–4 adverse events occurred in less than 2% of patients in either group. Interpretation: 5 years of treatment with aromatase inhibitors was not superior to 2 years of tamoxifen followed by 3 years of aromatase inhibitors. None of the three aromatase inhibitors was superior to the others in terms of efficacy. Therefore, patient preference, tolerability, and financial constraints should be considered when deciding the optimal treatment approach in this setting. Funding: Italian Drug Agency.

Published
2018

49. Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy

Author

Anna Crispo, Simona Malgieri, Stefania Cicala, Sabino De Placido, Grazia Arpino, Antonello Accurso, Annamaria Colao, Gennaro Limite, Michelino De Laurentiis, Valeria Forestieri, Giuseppe Buono, Dario Bruzzese, Bianca Maria Veneziani, Rossella Lauria, Carmine De Angelis, Mario Giuliano, Arpino, Grazia, DE ANGELIS, Carmine, Buono, Giuseppe, Colao, Annamaria, Giuliano, Mario, Malgieri, Simona, Cicala, Stefania, DE LAURENTIIS, Michelino, Accurso, Antonello, Crispo, Anna, Limite, Gennaro, Lauria, Rossella, Veneziani, BIANCA MARIA, Forestieri, Valeria, Bruzzese, Dario, and DE PLACIDO, Sabino

Subjects
Adult, Blood Glucose, Cancer Research, medicine.medical_specialty, Waist, Epidemiology, Breast Neoplasms, Gastroenterology, Adjuvant therapy, Body Mass Index, chemistry.chemical_compound, Glucose and lipid metabolism, Breast cancer, Waist–hip ratio, Internal medicine, Medicine, Body Fat Distribution, Humans, Insulin, Obesity, Triglycerides, medicine.diagnostic_test, Triglyceride, business.industry, Body weight and composition, Waist-Hip Ratio, Middle Aged, medicine.disease, Lipids, Postmenopause, Endocrinology, Oncology, chemistry, Female, medicine.symptom, Menopausal status, Waist Circumference, business, Lipid profile, Body mass index, Weight gain
Abstract

Weight gain and metabolic changes have been related to survival of early breast cancer patients (EBC). ‘’However, factors influencing metabolism post-diagnosis are not fully understood. We measured anthropometric [body mass index (BMI), body weight, waist and hip circumferences, and waist-to-hip ratio] and metabolic (levels of insulin, glucose, H1Ac, total, HDL, and LDL cholesterol, triglycerides, and the homeostasis model assessment score [HOMA]) parameters in 433 pre- and post-menopausal women with EBC at diagnosis and 3, 6, 9, 12, and 24 months thereafter. At diagnosis, compared with post-menopausal women, pre-menopausal patients were more likely to be leaner and to have a lower BMI, smaller waist and hip circumferences, and waist-to-hip ratio. They had also lower glucose, HbA1c, and triglyceride levels and a lower HOMA score. Furthermore, they were more likely to have an estrogen- and/or progesterone-positive tumor and a higher proliferating breast cancer. During the first two post-diagnosis years, all women showed a significant increase of weight (+0.72 kg/year, P

Published
2015

50. Oxidative stress mediates the antiproliferative effects of nelfinavir in breast cancer cells

Author

Pietro Forestieri, Gennaro Limite, Maria Rosaria Rusciano, Roberto Bianco, Maria Soprano, Matteo D’Alessio, D. Sorriento, Maddalena Illario, Dario D’Angelo, Pietro Formisano, Guido Iaccarino, Angela Serena Maione, Pietro Campiglia, Soprano, Maria, Sorriento, Daniela, Rusciano, Maria Rosaria, Maione, Angela Serena, Limite, Gennaro, Forestieri, Pietro, D'Angelo, Dario, D'Alessio, Matteo, Campiglia, Pietro, Formisano, Pietro, Iaccarino, Guido, Bianco, Roberto, and Illario, Maddalena

Subjects
0301 basic medicine, Cell, Cancer Treatment, Organic chemistry, lcsh:Medicine, Apoptosis, Pharmacology, Pathology and Laboratory Medicine, Epithelium, 0302 clinical medicine, Animal Cells, immune system diseases, Breast Tumors, Tumor Cells, Cultured, Medicine and Health Sciences, Vitamin E, Cell Cycle and Cell Division, lcsh:Science, Nelfinavir, Multidisciplinary, Oxidative Stress Mediates, Cancer, Cells, Cell Death, Medicine (all), virus diseases, Vitamins, Physical sciences, Chemistry, medicine.anatomical_structure, Oncology, Cell Processes, 030220 oncology & carcinogenesis, Female, Cellular Types, Anatomy, Research Article, medicine.drug, Programmed cell death, Antineoplastic Agents, Breast Neoplasms, Biology, Chemical compounds, Necrosis, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Cyclins, Breast Cancer, Organic compounds, medicine, Humans, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Biochemistry, Genetics and Molecular Biology (all), Cell growth, lcsh:R, Cancers and Neoplasms, Biology and Life Sciences, Epithelial Cells, HIV Protease Inhibitors, Cell Biology, biochemical phenomena, metabolism, and nutrition, Oxidative Stress, Biological Tissue, 030104 developmental biology, Agricultural and Biological Sciences (all), Cancer cell, lcsh:Q, Reactive Oxygen Species
Abstract

The discovery of the anti-proliferative activity of nelfinavir in HIV-free models has encouraged its investigation as anticancer drug. Although the molecular mechanism by which nelfinavir exerts antitumor activity is still unknown, its effects have been related to Akt inhibition. Here we tested the effects of nelfinavir on cell proliferation, viability and death in two human breast cancer cell lines and in human normal primary breast cells. To identify the mechanism of action of nelfinavir in breast cancer, we evaluated the involvement of the Akt pathway as well as the effects of nelfinavir on reactive oxygen species (ROS) production and ROS-related enzymes activities. Nelfinavir reduced breast cancer cell viability by inducing apoptosis and necrosis, without affecting primary normal breast cells. The antitumor activity of nelfinavir was related to alterations of the cell redox state, coupled with an increase of intracellular ROS production limited to cancer cells. Nelfinavir treated tumor cells also displayed a downregulation of the Akt pathway due to disruption of the Akt-HSP90 complex, and subsequent degradation of Akt. These effects resulted to be ROS dependent, suggesting that ROS production is the primary step of nelfinavir anticancer activity. The analysis of ROS-producers and ROS-detoxifying enzymes revealed that nelfinavir-mediated ROS production was strictly linked to flavoenzymes activation. We demonstrated that ROS enhancement represents the main molecular mechanism required to induce cell death by nelfinavir in breast cancer cells, thus supporting the development of new and more potent oxidizing molecules for breast cancer therapy.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results