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Improved polarization measurements at frequencies below 70 GHz with degree-level angular resolution are crucial for advancing our understanding of the Galactic synchrotron radiation and the potential polarized anomalous microwave emission and ultimately benefiting the detection of primordial $B$ modes. In this study, we present sensitivity-improved 40 GHz polarization maps obtained by combining the CLASS 40 GHz and WMAP $Q$-band data through a weighted average in the harmonic domain. The decision to include WMAP $Q$-band data stems from similarities in the bandpasses. Leveraging the accurate large-scale measurements from WMAP $Q$ band and the high-sensitivity information from CLASS 40 GHz band at intermediate scales, the noise level at $\ell\in[30, 100]$ is reduced by a factor of $2-3$ in the map space. A pixel domain analysis of the polarized synchrotron spectral index ($\beta_s$) using WMAP $K$ band and the combined maps (mean and 16/84th percentile across the $\beta_s$ map: $-3.08_{-0.20}^{+0.20}$) reveals a stronger preference for spatial variation (PTE for a uniform $\beta_s$ hypothesis smaller than 0.001) than the results obtained using WMAP $K$ and $Ka$ bands ($-3.08_{-0.14}^{+0.14}$). The cross-power spectra of the combined maps follow the same trend as other low-frequency data, and validation through simulations indicates negligible bias introduced by the combination method (sub-percent level in the power spectra). The products of this work are publicly available on $\mathtt{LAMBDA}$., Comment: 19 pages, 16 figures, 1 table, accepted for publication in ApJ

Artificial intelligence (AI)-driven methods can vastly improve the historically costly drug design process, with various generative models already in widespread use. Generative models for de novo drug design, in particular, focus on the creation of novel biological compounds entirely from scratch, representing a promising future direction. Rapid development in the field, combined with the inherent complexity of the drug design process, creates a difficult landscape for new researchers to enter. In this survey, we organize de novo drug design into two overarching themes: small molecule and protein generation. Within each theme, we identify a variety of subtasks and applications, highlighting important datasets, benchmarks, and model architectures and comparing the performance of top models. We take a broad approach to AI-driven drug design, allowing for both micro-level comparisons of various methods within each subtask and macro-level observations across different fields. We discuss parallel challenges and approaches between the two applications and highlight future directions for AI-driven de novo drug design as a whole. An organized repository of all covered sources is available at https://github.com/gersteinlab/GenAI4Drug.

The dynamic atmosphere imposes challenges to ground-based cosmic microwave background observation, especially for measurements on large angular scales. The hydrometeors in the atmosphere, mostly in the form of clouds, scatter the ambient thermal radiation and are known to be the main linearly polarized source in the atmosphere. This scattering-induced polarization is significantly enhanced for ice clouds due to the alignment of ice crystals under gravity, which are also the most common clouds seen at the millimeter-astronomy sites at high altitudes. This work presents a multifrequency study of cloud polarization observed by the Cosmology Large Angular Scale Surveyor (CLASS) experiment on Cerro Toco in the Atacama Desert of northern Chile, from 2016 to 2022, at the frequency bands centered around 40, 90, 150, and 220 GHz. Using a machine-learning-assisted cloud classifier, we made connections between the transient polarized emission found in all four frequencies with the clouds imaged by monitoring cameras at the observing site. The polarization angles of the cloud events are found to be mostly $90^\circ$ from the local meridian, which is consistent with the presence of horizontally aligned ice crystals. The 90 and 150 GHz polarization data are consistent with a power law with a spectral index of $3.90\pm0.06$, while an excess/deficit of polarization amplitude is found at 40/220 GHz compared with a Rayleigh scattering spectrum. These results are consistent with Rayleigh-scattering-dominated cloud polarization, with possible effects from supercooled water absorption and/or Mie scattering from a population of large cloud particles that contribute to the 220 GHz polarization., Comment: 16 pages, 14 figures, submitted to ApJ

Measurement of the largest angular scale ($\ell < 30$) features of the cosmic microwave background (CMB) polarization is a powerful way to constrain the optical depth to reionization and search for the signature of inflation through the detection of primordial $B$-modes. We present an analysis of maps covering 73.6\% of the sky made from the $40\,\mathrm{GHz}$ channel of the Cosmology Large Angular Scale Surveyor (CLASS) from 2016 August to 2022 May. Taking advantage of the measurement stability enabled by front-end polarization modulation and excellent conditions from the Atacama Desert, we show this channel achieves higher sensitivity than the analogous frequencies from satellite measurements in the range $10 < \ell < 100$. Simulations show the CLASS linear (circular) polarization maps have a white noise level of $125 \,(130)\,\mathrm{\mu K\, arcmin}$. We measure the Galaxy-masked $EE$ and $BB$ spectra of diffuse synchrotron radiation and compare to space-based measurements at similar frequencies. In combination with external data, we expand measurements of the spatial variations of the synchrotron spectral energy density (SED) to include new sky regions and measure the diffuse SED in the harmonic domain. We place a new upper limit on a background of circular polarization in the range $5 < \ell < 125$ with the first bin showing $D_\ell < 0.023$ $\mathrm{\mu K^2_{CMB}}$ at 95\% confidence. These results establish a new standard for recovery of the largest-scale CMB polarization from the ground and signal exciting possibilities when the higher sensitivity and higher-frequency CLASS channels are included in the analysis., Comment: 38 pages, 25 figures, 6 tables. Accepted to The Astrophysical Journal

The Cosmology Large Angular Scale Surveyor (CLASS) is a telescope array that observes the cosmic microwave background (CMB) over ~75% of the sky from the Atacama Desert, Chile, at frequency bands centered near 40, 90, 150, and 220 GHz. CLASS measures the large angular scale CMB polarization to constrain the tensor-to-scalar ratio and the optical depth to last scattering. This paper presents the optical characterization of the 90GHz telescope, which has been observing since July 2018. Observations of the Moon establish the pointing while dedicated observations of Jupiter are used for beam calibration. The standard deviations of the pointing error in azimuth, elevation, and boresight angle are 1.3, 2.1, and 2.0 arcminutes, respectively, over the first 3 years of observations. This corresponds to a pointing uncertainty ~7% of the beam's full width at half maximum (FWHM). The effective azimuthally-symmetrized instrument 1D beam estimated at 90 GHz has an FWHM of 0.620+/-0.003 deg and a solid angle of 138.7+/-0.6(stats.)+/-1.1(sys.) usr integrated to a radius of 4 deg. The corresponding beam window function drops to b_ell^2 = 0.93, 0.71, 0.14 at ell = 30, 100, 300, respectively. Far-sidelobes are studied using detector-centered intensity maps of the Moon and measured to be at a level of 10^-3 or below relative to the peak. The polarization angle of Tau A estimated from preliminary survey maps is 149.6+/-0.2(stats.) deg in equatorial coordinates. The instrumental temperature-to-polarization (T-to-P) leakage fraction, inferred from per-detector demodulated Jupiter scan data, has a monopole component at the level of 1.7 x 10^-3, a dipole component with an amplitude of 4.3 x 10^-3, with no evidence of quadrupolar leakage., Comment: 24 pages, 18 figures, submitted to ApJS

The Cosmology Large Angular Scale Surveyor (CLASS) is a telescope array that observes the cosmic microwave background over 75\% of the sky from the Atacama Desert, Chile, at frequency bands centered near 40, 90, 150, and 220~GHz. This paper describes the CLASS data pipeline and maps for 40~GHz observations conducted from August 2016 to May 2022. We demonstrate how well the CLASS survey strategy, with rapid ($\sim10\,\mathrm{Hz}$) front-end modulation, recovers the large-scale Galactic polarization signal from the ground: the mapping transfer function recovers $\sim75$\% of $EE$, $BB$, and $VV$ power at $\ell=20$ and $\sim45$\% at $\ell=10$. We present linear and circular polarization maps over 75\% of the sky. Simulations based on the data imply the maps have a white noise level of $110\,\mathrm{\mu K\, arcmin}$ and correlated noise component rising at low-$\ell$ as $\ell^{-2.2}$. The transfer-function-corrected low-$\ell$ component is comparable to the white noise at the angular knee frequencies of $\ell\approx16$ (linear polarization) and $\ell\approx12$ (circular polarization). Finally, we present simulations of the level at which expected sources of systematic error bias the measurements, finding sub-percent bias for the $\Lambda\mathrm{CDM}$ $EE$ power spectra. Bias from $E$-to-$B$ leakage due to the data reduction pipeline and polarization angle uncertainty approaches the expected level for an $r=0.01$ $BB$ power spectrum. Improvements to the instrument calibration and the data pipeline will decrease this bias., Comment: 29 pages, 17 figures; submitted to ApJ

Computational simulation of chemical and biological systems using ab initio molecular dynamics has been a challenge over decades. Researchers have attempted to address the problem with machine learning and fragmentation-based methods. However, the two approaches fail to give a satisfactory description of long-range and many-body interactions, respectively. Inspired by fragmentation-based methods, we propose the Long-Short-Range Message-Passing (LSR-MP) framework as a generalization of the existing equivariant graph neural networks (EGNNs) with the intent to incorporate long-range interactions efficiently and effectively. We apply the LSR-MP framework to the recently proposed ViSNet and demonstrate the state-of-the-art results with up to 40% MAE reduction for molecules in MD22 and Chignolin datasets. Consistent improvements to various EGNNs will also be discussed to illustrate the general applicability and robustness of our LSR-MP framework. The code for our experiments and trained model weights could be found at https://github.com/liyy2/LSR-MP.

We report on the disk-averaged absolute brightness temperatures of Venus measured at four microwave frequency bands with the Cosmology Large Angular Scale Surveyor (CLASS). We measure temperatures of 432.3 $\pm$ 2.8 K, 355.6 $\pm$ 1.3 K, 317.9 $\pm$ 1.7 K, and 294.7 $\pm$ 1.9 K for frequency bands centered at 38.8, 93.7, 147.9, and 217.5 GHz, respectively. We do not observe any dependence of the measured brightness temperatures on solar illumination for all four frequency bands. A joint analysis of our measurements with lower frequency Very Large Array (VLA) observations suggests relatively warmer ($\sim$ 7 K higher) mean atmospheric temperatures and lower abundances of microwave continuum absorbers than those inferred from prior radio occultation measurements., Comment: 10 pages, 3 figures, published in PSJ

The Cosmology Large Angular Scale Surveyor (CLASS) telescope array surveys 75% of the sky from the Atacama desert in Chile at frequency bands centered near 40, 90, 150, and 220 GHz. CLASS measures the largest-angular-scale CMB polarization with the aim of constraining the tensor-to-scalar ratio, measuring the optical depth to reionization to near the cosmic variance limit, and more. The CLASS Q-band (40 GHz), W-band (90 GHz), and dichroic high frequency (150/220 GHz) telescopes have been observing since June 2016, May 2018, and September 2019, respectively. On-sky optical characterization of the 40 GHz instrument has been published. Here, we present preliminary on-sky measurements of the beams at 90, 150, and 220 GHz, and pointing stability of the 90 and 150/220 GHz telescopes. The average 90, 150, and 220 GHz beams measured from dedicated observations of Jupiter have full width at half maximum (FWHM) of 0.615+/-0.019 deg, 0.378+/-0.005 deg, and 0.266+/-0.008 deg, respectively. Telescope pointing variations are within a few percent of the beam FWHM., Comment: Submitted to Proc. SPIE Astronomical Telescopes and Instrumentation (2022)

The Cosmology Large Angular Scale Surveyor (CLASS) is a telescope array observing the Cosmic Microwave Background (CMB) at frequency bands centered near 40, 90, 150, and 220 GHz. CLASS measures the CMB polarization on the largest angular scales to constrain the inflationary tensor-to-scalar ratio and the optical depth due to reionization. To achieve the long time-scale stability necessary for this measurement from the ground, CLASS utilizes a front-end, variable-delay polarization modulator on each telescope. Here we report on the improvements in stability afforded by front-end modulation using data across all four CLASS frequencies. Across one month of modulated linear polarization data in 2021, CLASS achieved median knee frequencies of 9.1, 29.1, 20.4, and 36.4 mHz for the 40, 90, 150, and 220 GHz observing bands. The knee frequencies are approximately an order of magnitude lower than achieved via CLASS pair-differencing orthogonal detector pairs without modulation., Comment: Submitted to SPIE Astronomical Telescopes + Instrumentation 2022 Conference (AS22)

In this paper, we explore the power of the cosmic microwave background (CMB) polarization (E-mode) data to corroborate four potential anomalies in CMB temperature data: the lack of large angular-scale correlations, the alignment of the quadrupole and octupole (Q-O), the point-parity asymmetry, and the hemispherical power asymmetry. We use CMB simulations with noise representative of three experiments -- the Planck satellite, the Cosmology Large Angular Scale Surveyor (CLASS), and the LiteBIRD satellite -- to test how current and future data constrain the anomalies. We find the correlation coefficients $\rho$ between temperature and E-mode estimators to be less than $0.1$, except for the point-parity asymmetry ($\rho=0.17$ for cosmic-variance-limited simulations), confirming that E-modes provide a check on the anomalies that is largely independent of temperature data. Compared to Planck component-separated CMB data (SMICA), the putative LiteBIRD survey would reduce errors on E-mode anomaly estimators by factors of $\sim 3$ for hemispherical power asymmetry and point-parity asymmetry, and by $\sim 26$ for lack of large-scale correlation. The improvement in Q-O alignment is not obvious due to large cosmic variance, but we found the ability to pin down the estimator value will be improved by a factor $\gtrsim100$. Improvements with CLASS are intermediate to these., Comment: 23 pages, 15 figures, 6 tables. Published in ApJ

The current and future cosmic microwave background (CMB) experiments fielding kilo-pixel arrays of transition-edge sensor (TES) bolometers require accurate and robust gain calibration methods. We simplify and refactor the standard TES model to directly relate the detector responsivity calibration and optical time constant to the measured TES current $I$ and the applied bias current $I_{\mathrm{b}}$. The calibration method developed for the Cosmology Large Angular Scale Surveyor (CLASS) TES bolometer arrays relies on current versus voltage ($I$-$V$) measurements acquired daily prior to CMB observations. By binning Q-band (40GHz) $I$-$V$ measurements by optical loading, we find that the gain calibration median standard error within a bin is 0.3%. We test the accuracy of this "$I$-$V$ bin" detector calibration method by using the Moon as a photometric standard. The ratio of measured Moon amplitudes between detector pairs sharing the same feedhorn indicates a TES calibration error of 0.5%. We also find that for the CLASS Q-band TES array, calibrating the response of individual detectors based solely on the applied TES bias current accurately corrects TES gain variations across time but introduces a bias in the TES calibration from data counts to power units. Since the TES current bias value is set and recorded before every observation, this calibration method can always be applied to raw TES data and is not subject to $I$-$V$ data quality or processing errors., Comment: 19 pages, 7 figures, 5 tables. Submitted to ApJS May 2022. Published ApJS Oct 2022

The Cosmology Large Angular Scale Surveyor (CLASS) observes the polarized cosmic microwave background (CMB) over the angular scales of 1$^\circ \lesssim \theta \leq$ 90$^\circ$ with the aim of characterizing primordial gravitational waves and cosmic reionization. We report on the on-sky performance of the CLASS Q-band (40 GHz), W-band (90 GHz), and dichroic G-band (150/220 GHz) receivers that have been operational at the CLASS site in the Atacama desert since June 2016, May 2018, and September 2019, respectively. We show that the noise-equivalent power measured by the detectors matches the expected noise model based on on-sky optical loading and lab-measured detector parameters. Using Moon, Venus, and Jupiter observations, we obtain power-to-antenna-temperature calibrations and optical efficiencies for the telescopes. From the CMB survey data, we compute instantaneous array noise-equivalent-temperature sensitivities of 22, 19, 23, and 71 $\mathrm{\mu K}_\mathrm{cmb}\sqrt{\mathrm{s}}$ for the 40, 90, 150, and 220 GHz frequency bands, respectively. These noise temperatures refer to white noise amplitudes, which contribute to sky maps at all angular scales. Future papers will assess additional noise sources impacting larger angular scales., Comment: 13 pages, 3 figures, published in ApJ

The Sunyaev-Zel'dovich (SZ) effect introduces a specific distortion of the blackbody spectrum of the cosmic microwave background (CMB) radiation when it scatters off hot gas in clusters of galaxies. The frequency dependence of the distortion is only independent of the cluster redshift when the evolution of the CMB radiation is adiabatic. Using 370 clusters within the redshift range $0.07\lesssim z\lesssim1.4$ from the largest SZ-selected cluster sample to date from the Atacama Cosmology Telescope, we provide new constraints on the deviation of CMB temperature evolution from the standard model $\alpha=0.017^{+0.029}_{-0.032}$, where $T(z)=T_0(1+z)^{1-\alpha}$. This result is consistent with no deviation from the standard adiabatic model. Combining it with previous, independent datasets we obtain a joint constraint of $\alpha=-0.001\pm0.012$. Attributing deviation from adiabaticity to the decay of dark energy, this result constrains its effective equation of state $w_\mathrm{eff}=-0.998^{+0.008}_{-0.010}$.

The Cosmology Large Angular Scale Surveyor (CLASS) is a four-telescope array observing the largest angular scales ($2 \lesssim \ell \lesssim 200$) of the cosmic microwave background (CMB) polarization. These scales encode information about reionization and inflation during the early universe. The instrument stability necessary to observe these angular scales from the ground is achieved through the use of a variable-delay polarization modulator (VPM) as the first optical element in each of the CLASS telescopes. Here we develop a demodulation scheme used to extract the polarization timestreams from the CLASS data and apply this method to selected data from the first two years of observations by the 40 GHz CLASS telescope. These timestreams are used to measure the $1/f$ noise and temperature-to-polarization ($T\rightarrow P$) leakage present in the CLASS data. We find a median knee frequency for the pair-differenced demodulated linear polarization of 15.12 mHz and a $T\rightarrow P$ leakage of $<3.8\times10^{-4}$ (95\% confidence) across the focal plane. We examine the sources of $1/f$ noise present in the data and find the component of $1/f$ due to atmospheric precipitable water vapor (PWV) has an amplitude of $203 \pm 12 \mathrm{\mu K_{RJ}\sqrt{s}}$ for 1 mm of PWV when evaluated at 10 mHz; accounting for $\sim32\%$ of the $1/f$ noise in the central pixels of the focal plane. The low level of $T\rightarrow P$ leakage and $1/f$ noise achieved through the use of a front-end polarization modulator enables the observation of the largest scales of the CMB polarization from the ground by the CLASS telescopes., Comment: Submitted to ApJ

The Cosmology Large Angular Scale Surveyor (CLASS) is a telescope array that observes the cosmic microwave background (CMB) over 75% of the sky from the Atacama Desert, Chile, at frequency bands centered near 40, 90, 150, and 220 GHz. CLASS measures the large angular scale ($1^\circ\lesssim\theta\leqslant 90^\circ$) CMB polarization to constrain the tensor-to-scalar ratio at the $r\sim0.01$ level and the optical depth to last scattering to the sample variance limit. This paper presents the optical characterization of the 40 GHz telescope during its first observation era, from 2016 September to 2018 February. High signal-to-noise observations of the Moon establish the pointing and beam calibration. The telescope boresight pointing variation is $<0.023^\circ$ ($<1.6$% of the beam's full width at half maximum (FWHM)). We estimate beam parameters per detector and in aggregate, as in the CMB survey maps. The aggregate beam has an FWHM of $1.579^\circ\pm.001^\circ$ and a solid angle of $838 \pm 6\ \mu{\rm sr}$, consistent with physical optics simulations. The corresponding beam window function has a sub-percent error per multipole at $\ell < 200$. An extended $90^\circ$ beam map reveals no significant far sidelobes. The observed Moon polarization shows that the instrument polarization angles are consistent with the optical model and that the temperature-to-polarization leakage fraction is $<10^{-4}$ (95% C.L.). We find that the Moon-based results are consistent with measurements of M42, RCW 38, and Tau A from CLASS's CMB survey data. In particular, Tau A measurements establish degree-level precision for instrument polarization angles., Comment: 32 pages, 24 figures, published in ApJ

We report circular polarization measurements from the first two years of observation with the 40 GHz polarimeter of the Cosmology Large Angular Scale Surveyor (CLASS). CLASS is conducting a multi-frequency survey covering 75% of the sky from the Atacama Desert designed to measure the cosmic microwave background (CMB) linear E and B polarization on angular scales $1^\circ \lesssim \theta \leq 90^\circ$, corresponding to a multipole range of $2 \leq \ell \lesssim 200$. The modulation technology enabling measurements of linear polarization at the largest angular scales from the ground, the Variable-delay Polarization Modulator, is uniquely designed to provide explicit sensitivity to circular polarization (Stokes $V$). We present a first detection of circularly polarized atmospheric emission at 40 GHz that is well described by a dipole with an amplitude of $124\pm4\,\mathrm{\mu K}$ when observed at an elevation of $45^\circ$, and discuss its potential impact as a foreground to CMB experiments. Filtering the atmospheric component, CLASS places a 95% C.L. upper limit of $0.4\,\mathrm{\mu K}^2$ to $13.5\,\mathrm{\mu K}^2$ on $\ell(\ell+1)C_\ell^{VV}/(2\pi)$ between $1 \leq \ell \leq 120$, representing a two-orders-of-magnitude improvement over previous limits., Comment: 8 pages, 5 figures

We summarize and reanalyze observations bearing upon missing galactic baryons, where we propose a consistent picture for halo gas in L >~ L* galaxies. The hot X-ray emitting halos are detected to 50-70 kpc, where typically, M_hot(<50 kpc) ~ 5E9 Msun, and with density n \propto r^-3/2. When extrapolated to R200, the gas mass is comparable to the stellar mass, but about half of the baryons are still missing from the hot phase. If extrapolated to 1.9-3 R200, the baryon to dark matter ratio approaches the cosmic value. Significantly flatter density profiles are unlikely for R < 50 kpc and they are disfavored but not ruled out for R > 50 kpc. For the Milky Way, the hot halo metallicity lies in the range 0.3-1 solar for R < 50 kpc. Planck measurements of the thermal Sunyaev-Zeldovich effect toward stacked luminous galaxies (primarily early-type) indicate that most of their baryons are hot, near the virial temperature, and extend beyond R200. This stacked SZ signal is nearly an order of magnitude larger than that inferred from the X-ray observations of individual (mostly spiral) galaxies with M_* > 10^11.3 Msun. This difference suggests that the hot halo properties are distinct for early and late type galaxies, possibly due to different evolutionary histories. For the cooler gas detected in UV absorption line studies, we argue that there are two absorption populations: extended halos; and disks extending to ~50 kpc, containing most of this gas, and with masses a few times lower than the stellar masses. Such extended disks are also seen in 21 cm HI observations and in simulations., Comment: 22 pages, 20 figures, 2 tables, submitted to ApJ

The extended hot X-ray emitting gaseous halo of the Milky Way has an optical depth $\sim1$ for the dominant emission lines of \ion{O}{7} and \ion{O}{8}, which are used to infer the halo properties. To improve on halo gas properties, we treat optical depth effects with a Monte-Carlo radiative transfer model, which leads to slightly steeper density profiles ($\beta \approx 0.5$) than if optical depths effects were ignored. For the preferred model where the halo is rotating on cylinders at $180$ km s$^{-1}$, independent fits to both lines lead to identical results, where the core radius is $2.5$ kpc and the turbulent component of the Doppler b parameter is $100-120$ km s$^{-1}$; the turbulent pressure is $20\%$ of the thermal pressure. The fit is improved when emission from a disk is included, with a radial scale length of $3$ kpc (assumed) and a fitted vertical scale height of approximately $1.3$ kpc. The disk component is a minor mass constituent and has low optical depth, except at low latitudes. The gaseous mass is $3-4\times10^{10}\,M_{\odot}$ within $250\,\mathrm{kpc}$, similar to our previous determinations and significantly less than the missing baryons of $1.7\times10^{11}\,M_{\odot}$.

Calvera is a $59\,\mathrm{ms}$ isolated pulsar, being unique due to its non-detection in radio, optical and gamma-rays but the purely thermal emission in soft X-rays. It is suggested that Calvera could be an ordinary middle-aged pulsar with significant magnetospheric activity at a large distance. Alternatively, it is proposed in this paper that Calvera is a low-mass strangeon star with inactive magnetosphere (dead). In this scenario, we jointly fit the spectra obtained by the {\it XMM-Newton} Observatory and the {\it Chandra} X-ray Observatory with the strangeon star atmosphere model. The spectral model is successful in explaining the radiation properties of Calvera and X-ray Dim Isolated Neutron Stars, both showing similar observation features. Within the dead pulsar picture, Calvera might be of high temperature at $0.67\,\mathrm{keV}$, possessing a small stellar radius $R\la4\,\mathrm{km}$ and a presumably small magnetic field $B\la10^{11}\,\mathrm{G}$ and is probably braked by the fall-back disk accretion. Future advanced facilities may provide unique opportunities to know the real nature of Calvera.

X-ray-dim isolated neutron stars (XDINSs), also known as the Magnificent Seven, exhibits a Planck-like soft X-ray spectrum. In the optical/ultraviolet(UV) band, there is an excess of radiation compared to the extrapolation from the X-ray spectrum. A model of bremsstrahlung emission from a nonuniform plasma atmosphere is proposed in the regime of a strangeon star to explain the optical/UV excess and its spectral deviation. The nonuniform atmosphere is formed by the accretion of interstellar matter which moves along the magnetic field lines to polar caps, and these particles may spread out of the pole regions. The modeled electron temperatures are $\sim100-200$ eV with radiation radii $R_{\rm opt}^{\infty}\sim5-14$ km. The spectra of five sources (RX J0720.4--3125, RX J0806.4--4123, RX J1308.6+2127, RX J1605.3+3249, RX J1856.5--3754) from optical/UV to X-ray bands could be well fitted by the radiative model, and exhibit gaussian absorption lines at $\sim 100-500$ eV as would be expected. Furthermore, the surroundings (i.e., fallback disks or dusty belts) of XDINSs could be tested by future observations with the Large Optical Telescope (LOT)., Comment: 14 pages, 6 figures, RAA accepted