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914 results on '"LI Hong-li"'

1. Research progress on the influence of black tea fermentation conditions on the tea pigment formation

Author

CUI Hong-chun, ZHANG Jian-yong, ZHAO Yun, HUANG Hai-tao, AO Cun, LI Hong-li, and SHI Da-liang

Subjects
fermentation, black tea, tea pigment, formation, Food processing and manufacture, TP368-456
Abstract

The research progress of the influence of fermentation temperature, fermentation humidity, fermentation time and exogenous additives on the formation of black tea pigment were reviewed. The future research and development trend of black tea pigment formation was prospected.

Published
2022
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18. Adenovirus-mediated delivery of interferon-γ gene inhibits the growth of nasopharyngeal carcinoma

Author

Liu Ran-yi, Zhu Ying-hui, Zhou Ling, Zhao Peng, Li Hong-li, Zhu Lan-cai, Han Hong-yu, Lin Huan-xin, Kang Liang, Wu Jiang-xue, and Huang Wenlin

Subjects
Gene therapy, Interferon-γ, Nasopharyngeal carcinoma, Adenoviral vector, Medicine
Abstract

Abstract Background Interferon-γ (IFN-γ) is regarded as a potent antitumor agent, but its clinical application is limited by its short half-life and significant side effects. In this paper, we tried to develop IFN-γ gene therapy by a replication defective adenovirus encoding the human IFN-γ (Ad-IFNγ), and evaluate the antitumoral effects of Ad-IFNγ on nasopharyngeal carcinoma (NPC) cell lines in vitro and in xenografts model. Methods The mRNA levels of human IFN-γ in Ad-IFNγ-infected NPC cells were detected by reverse transcription-polymerase chain reaction (RT-PCR), and IFN-γ protein concentrations were measured by enzyme-linked immunosorbent assay (ELISA) in the culture supernatants of NPC cells and tumor tissues and bloods of nude mice treated with Ad-IFNγ. The effects of Ad-IFNγ on NPC cell proliferation was determined using MTT assay, cell cycle distribution was determined by flow cytometry analysis for DNA content, and cells apoptosis were analyzed by Annexin V-FITC/7-AAD binding assay and hoechst 33342/PI double staining. The anti-tumor effects and toxicity of Ad-IFNγ were evaluated in BALB/c nude mice carrying NPC xenografts. Results The results demonstrated that Ad-IFNγ efficiently expressed human IFN-γ protein in NPC cell lines in vitro and in vivo. Ad-IFNγ infection resulted in antiproliferative effects on NPC cells by inducing G1 phase arrest and cell apoptosis. Intratumoral administration of Ad-IFNγ significantly inhibited the growth of CNE-2 and C666-1 cell xenografts in nude mice, while no significant toxicity was observed. Conclusions These findings indicate IFN-γ gene therapy mediated by replication defective adenoviral vector is likely a promising approach in the treatment of nasopharyngeal carcinoma.

Published
2012
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26. Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, China

Author

Liu, Chun-Hua, Liu, Hong-Yan, Peng, Si-Cong, Pan, Sha, Wan, Zhi-Ting, Wu, Su-Ying, Fang, Chao-Ce, Jiao, Rong, Wang, Wen-Xiang, Gan, Bin, Shu-JieYang, Tan, Ju-Fang, Zhu, Xiao-Fang, She, Ping-Li, Fan, Qi-Hong, Yang, Min, Xie, Ji-Jian, Sun, Jie, Zeng, Ling, Zhang, Lian-Hong, Xu, Hui-Rong, Li, Yan-Ni, Zhang, Ping-Feng, Lu, Wei, Yang, Xian-Tao, Xiao, Xiong-Fei, Li, Hong-Li, Rao, Zheng-Liang, Gao, Chuang, Luo, Ya-Hui, Chen, Hong, Yu, Ming-Jin, Luan, Xiao-Ying, Huang, Yu-Rong, and Xia, Shi-Wen

Published
2023
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41. Identifying key monitoring areas for tree insect pest risks in China under climate change.

Author

Zhang, Fei-Xue, Li, Hong-Li, Wan, Ji-Zhong, and Wang, Chun-Jing

Subjects
TREE diseases & pests, INSECT pests, PEST control, NATURE reserves, CLIMATE change
Abstract

Climate change can exacerbate pest population growth, posing significant threats to ecosystem functions and services, social development, and food security. Risk assessment is a valuable tool for effective pest management that identifies potential pest expansion and ecosystem dispersal patterns. We applied a habitat suitability model coupled with priority protection planning software to determine key monitoring areas (KMA) for tree insect pest risks under climate change and used forest ecoregions and nature reserves to assess the ecological risk of insect pest invasion. Finally, we collated the prevention and control measures for reducing future pest invasions. The KMA for tree insect pests in our current and future climate is mainly concentrated in eastern and southern China. However, with climate change, the KMA gradually expands from southeastern to northeastern China. In the current and future climate scenarios, ecoregions requiring high monitoring levels were restricted to the eastern and southern coastal areas of China, and nature reserves requiring the highest monitoring levels were mainly distributed in southeastern China. Tree insect pest invasion assessment using ecoregions and nature reserves identified that future climates increase the risk of pest invasions in forest ecoregions and nature reserves, especially in northeastern China. The increased risk and severity of tree insect pest invasions require implementing monitoring and preventative measures in these areas. We effectively assessed the pest invasion risks using forest ecoregions and nature reserves under climate change. Our assessments suggest that monitoring and early prevention should focus on southeastern and northeastern China. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia

Author

Wang, Fei, Yang, Yu-Jian, Yang, Nian, Chen, Xian-Jun, Huang, Nan-Xin, Zhang, Jun, Wu, Yi, Liu, Zhi, Gao, Xing, Li, Tao, Pan, Guang-Qiang, Liu, Shu-Bao, Li, Hong-Li, Fancy, Stephen PJ, Xiao, Lan, Chan, Jonah R, and Mei, Feng

Subjects
Paediatrics, Biomedical and Clinical Sciences, Preterm, Low Birth Weight and Health of the Newborn, Brain Disorders, Rehabilitation, Pediatric, Infant Mortality, Neurosciences, Perinatal Period - Conditions Originating in Perinatal Period, Neurological, Animals, Animals, Newborn, Chronic Disease, Female, Hypoxia, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Myelin Sheath, Neurogenesis, Oligodendroglia, Receptor, Muscarinic M1, Recovery of Function, Synapses, M1R, Olig2, U-50488, beam-walking test, clemastine, hypomyelination, kappa opioid receptor, synaptogenesis, vGlut1, white matter injury, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

To address the significance of enhancing myelination for functional recovery after white matter injury (WMI) in preterm infants, we characterized hypomyelination associated with chronic hypoxia and identified structural and functional deficits of excitatory cortical synapses with a prolonged motor deficit. We demonstrate that genetically delaying myelination phenocopies the synaptic and functional deficits observed in mice after hypoxia, suggesting that myelination may possibly facilitate excitatory presynaptic innervation. As a gain-of-function experiment, we specifically ablated the muscarinic receptor 1 (M1R), a negative regulator of oligodendrocyte differentiation in oligodendrocyte precursor cells. Genetically enhancing oligodendrocyte differentiation and myelination rescued the synaptic loss after chronic hypoxia and promoted functional recovery. As a proof of concept, drug-based myelination therapies also resulted in accelerated differentiation and myelination with functional recovery after chronic hypoxia. Together, our data indicate that myelination-enhancing strategies in preterm infants may represent a promising therapeutic approach for structural/functional recovery after hypoxic WMI.

Published
2018

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