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1,141 results on '"LEROY, XAVIER"'

2. Definitions of major bleeding for predicting mortality in critically ill adult patients who survived 24 hours while supported with peripheral veno-arterial extracorporeal membrane oxygenation for cardiogenic shock: a comparative historical cohort study

Author

Moussa, Mouhamed D., Soquet, Jérôme, Robin, Emmanuel, Labreuche, Julien, Rousse, Natacha, Rauch, Antoine, Loobuyck, Valentin, Leroy, Guillaume, Duburcq, Thibault, Gantois, Guillaume, Leroy, Xavier, Ait-Ouarab, Slimane, Lamer, Antoine, Thellier, Lise, Lukowiak, Oliver, Schurtz, Guillaume, Muller, Christophe, Juthier, Francis, Susen, Sophie, and Vincentelli, André

Published
2024
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3. Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor

Author

Turpin, Anthony, Delliaux, Carine, Parent, Pauline, Chevalier, Hortense, Escudero-Iriarte, Carmen, Bonardi, Franck, Vanpouille, Nathalie, Flourens, Anne, Querol, Jessica, Carnot, Aurélien, Leroy, Xavier, Herranz, Nicolás, Lanel, Tristan, Villers, Arnauld, Olivier, Jonathan, Touzet, Hélène, de Launoit, Yvan, Tian, Tian V., and Duterque-Coquillaud, Martine

Published
2023
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5. Efficient Extensional Binary Tries

Author

Appel, Andrew W and Leroy, Xavier

Subjects
Computer Science - Logic in Computer Science, Computer Science - Programming Languages
Abstract

Lookup tables (finite maps) are a ubiquitous data structure. In pure functional languages they are best represented using trees instead of hash tables. In pure functional languages within constructive logic, without a primitive integer type, they are well represented using binary tries instead of search trees. In this work, we introduce canonical binary tries, an improved binary-trie data structure that enjoys a natural extensionality property, quite useful in proofs, and supports sparseness more efficiently. We provide full proofs of correctness in Coq. We provide microbenchmark measurements of canonical binary tries versus several other data structures for finite maps, in a variety of application contexts; as well as measurement of canonical versus original tries in two big, real systems. The application context of data structures contained in theorem statements imposes unusual requirements for which canonical tries are particularly well suited.

Published
2021
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7. Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients

Author

Fuchs, Talia L., Maclean, Fiona, Turchini, John, Vargas, A. Cristina, Bhattarai, Selina, Agaimy, Abbas, Hartmann, Arndt, Kao, Chia-Sui, Ellis, Carla, Bonert, Michael, Leroy, Xavier, Kunju, Lakshmi P., Schwartz, Lauren, Matsika, Admire, Williamson, Sean R., Rao, Priya, Divatia, Mukul, Guarch, Rosa, Algaba, Ferran, Balancin, Marcelo L., Zhou, Ming, Samaratunga, Hemamali, da Cunha, Isabela Werneck, Brimo, Fadi, Ryan, Andrew, Clouston, David, Aron, Manju, O’Donnell, Marie, Chan, Emily, Hirsch, Michelle S., Moch, Holger, Pang, Chun-Yin, Wah, Cheuk, Yin, Weihua, Perry-Keene, Joanna, Yilmaz, Asli, Chou, Angela, Clarkson, Adele, van der Westhuizen, Gerhard, Morrison, Ella, Zwi, Jonathan, Hes, Ondrej, Trpkov, Kiril, and Gill, Anthony J.

Published
2022
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10. Définitions de l’hémorragie majeure pour prédire la mortalité chez la patientèle adulte gravement malade ayant survécu 24 heures sous oxygénation par membrane extracorporelle veino-artérielle périphérique pour un choc cardiogénique : une étude de cohorte historique comparative

Author

Moussa, Mouhamed D., primary, Soquet, Jérôme, additional, Robin, Emmanuel, additional, Labreuche, Julien, additional, Rousse, Natacha, additional, Rauch, Antoine, additional, Loobuyck, Valentin, additional, Leroy, Guillaume, additional, Duburcq, Thibault, additional, Gantois, Guillaume, additional, Leroy, Xavier, additional, Ait-Ouarab, Slimane, additional, Lamer, Antoine, additional, Thellier, Lise, additional, Lukowiak, Oliver, additional, Schurtz, Guillaume, additional, Muller, Christophe, additional, Juthier, Francis, additional, Susen, Sophie, additional, and Vincentelli, André, additional

Published
2024
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11. Downregulation of the FTO m6A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors

Author

Jeschke, Jana, Collignon, Evelyne, Al Wardi, Clémence, Krayem, Mohammad, Bizet, Martin, Jia, Yan, Garaud, Soizic, Wimana, Zéna, Calonne, Emilie, Hassabi, Bouchra, Morandini, Renato, Deplus, Rachel, Putmans, Pascale, Dube, Gaurav, Singh, Nitesh Kumar, Koch, Alexander, Shostak, Kateryna, Rizzotto, Lara, Ross, Robert L., Desmedt, Christine, Bareche, Yacine, Rothé, Françoise, Lehmann-Che, Jacqueline, Duterque-Coquillaud, Martine, Leroy, Xavier, Menschaert, Gerben, Teixeira, Luis, Guo, Mingzhou, Limbach, Patrick A., Close, Pierre, Chariot, Alain, Leucci, Eleonora, Ghanem, Ghanem, Yuan, Bi-Feng, Willard-Gallo, Karen, Sotiriou, Christos, Marine, Jean-Christophe, and Fuks, François

Published
2021
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14. Mechanized semantics

Author

Leroy, Xavier

Subjects
Computer Science - Programming Languages
Abstract

The goal of this lecture is to show how modern theorem provers---in this case, the Coq proof assistant---can be used to mechanize the specification of programming languages and their semantics, and to reason over individual programs and over generic program transformations, as typically found in compilers. The topics covered include: operational semantics (small-step, big-step, definitional interpreters); a simple form of denotational semantics; axiomatic semantics and Hoare logic; generation of verification conditions, with application to program proof; compilation to virtual machine code and its proof of correctness; an example of an optimizing program transformation (dead code elimination) and its proof of correctness.

Published
2010
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15. A formally verified compiler back-end

Author

Leroy, Xavier

Subjects
Computer Science - Logic in Computer Science, Computer Science - Programming Languages
Abstract

This article describes the development and formal verification (proof of semantic preservation) of a compiler back-end from Cminor (a simple imperative intermediate language) to PowerPC assembly code, using the Coq proof assistant both for programming the compiler and for proving its correctness. Such a verified compiler is useful in the context of formal methods applied to the certification of critical software: the verification of the compiler guarantees that the safety properties proved on the source code hold for the executable compiled code as well.

Published
2009
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16. Compilation of extended recursion in call-by-value functional languages

Author

Hirschowitz, Tom, Leroy, Xavier, and Wells, J. B.

Subjects
Computer Science - Programming Languages
Abstract

This paper formalizes and proves correct a compilation scheme for mutually-recursive definitions in call-by-value functional languages. This scheme supports a wider range of recursive definitions than previous methods. We formalize our technique as a translation scheme to a lambda-calculus featuring in-place update of memory blocks, and prove the translation to be correct., Comment: 62 pages, uses pic

Published
2009
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17. Mechanized semantics for the Clight subset of the C language

Author

Blazy, Sandrine and Leroy, Xavier

Subjects
Computer Science - Programming Languages
Abstract

This article presents the formal semantics of a large subset of the C language called Clight. Clight includes pointer arithmetic, "struct" and "union" types, C loops and structured "switch" statements. Clight is the source language of the CompCert verified compiler. The formal semantics of Clight is a big-step operational semantics that observes both terminating and diverging executions and produces traces of input/output events. The formal semantics of Clight is mechanized using the Coq proof assistant. In addition to the semantics of Clight, this article describes its integration in the CompCert verified compiler and several ways by which the semantics was validated., Comment: Journal of Automated Reasoning (2009)

Published
2009
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18. Practice patterns and survival outcomes for muscle-invasive bladder cancer: real-life experience in a general population setting.

Author

Plouvier, Sandrine D, Marcq, Gautier, Vankemmel, Olivier, Colin, Pierre, Bonnal, Jean-Louis, Leroy, Xavier, Saint, Fabien, and Pasquier, David

Abstract

Bladder cancer (BC) is a common malignancy in Europe and North America. Among BCs, muscle-invasive BCs (MIBCs) are distinguished, as they require aggressive treatment due to their spreading potential and poor prognosis. Despite its clinical relevance, little information on MIBC in a general population setting is available. This study aims to report practice patterns and survival outcomes for MIBC patients in a general population setting. MIBCs among BC incidence in 2011 and 2012 recorded in a French population-based cancer registry (810 000 inhabitants) were included in the study. Data were extracted from the medical files. Individual, tumour-related characteristics and initial management including diagnostic tools, multidisciplinary team meeting (MDT) assessment, and treatment delivered were described. Cystectomy, chemoradiation, radiotherapy, and chemotherapy were considered as specific treatments. Matching between MDT decision and the treatment provided was detailed. Management practices were discussed according to the guideline's recommendations. Overall survival (using the Kaplan–Meier method) and net survival (using the Pohar-Perme estimator) were calculated. Among 538 incident BC cases, 147 (27.3%) were MIBCs. Diagnostic practices displayed a relevant locoregional assessment of BC. Almost all cases (n  = 136, 92.5%) were assessed during an uro-oncological MDT with a median time from diagnosis of 18 days (first quartile:12-third quartile:32). Discrepancies appeared between MDT decisions and treatments delivered: 71 out of 86 subjects received the recommended cystectomy or chemoradiation (with or without neoadjuvant chemotherapy); 6 out of 11 had the recommended radio- or chemotherapy; and 9 patients did not undergo any specific treatment despite the MDT decision. Cystectomy was the most common treatment performed; the time to surgery appeared consistent with the guideline's recommendations. Forty people only received supportive care. Still, the 5-year overall and net survival was poor, with 19% (13–26) and 22% (14–31), respectively. The 5-year net survival was 35% (23–48) for people who underwent curative-intent treatments. MIBC management remains challenging even for cases assessed during an MDT. Many people did not undergo any specific treatment. Prognosis was poor even when curative-intent therapies were delivered. Efforts to reduce exposure to risk factors such as tobacco smoking and occupational exposures must be maintained. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Coinductive big-step operational semantics

Author

Leroy, Xavier and Grall, Hervé

Subjects
Computer Science - Programming Languages
Abstract

Using a call-by-value functional language as an example, this article illustrates the use of coinductive definitions and proofs in big-step operational semantics, enabling it to describe diverging evaluations in addition to terminating evaluations. We formalize the connections between the coinductive big-step semantics and the standard small-step semantics, proving that both semantics are equivalent. We then study the use of coinductive big-step semantics in proofs of type soundness and proofs of semantic preservation for compilers. A methodological originality of this paper is that all results have been proved using the Coq proof assistant. We explain the proof-theoretic presentation of coinductive definitions and proofs offered by Coq, and show that it facilitates the discovery and the presentation of the results.

Published
2008

31. Data from PLA2R1 Mediates Tumor Suppression by Activating JAK2

Author

Vindrieux, David, primary, Augert, Arnaud, primary, Girard, Christophe A., primary, Gitenay, Delphine, primary, Lallet-Daher, Helene, primary, Wiel, Clotilde, primary, Le Calvé, Benjamin, primary, Gras, Baptiste, primary, Ferrand, Mylène, primary, Verbeke, Stéphanie, primary, de Launoit, Yvan, primary, Leroy, Xavier, primary, Puisieux, Alain, primary, Aubert, Sébastien, primary, Perrais, Michael, primary, Gelb, Michael, primary, Simonnet, Hélène, primary, Lambeau, Gérard, primary, and Bernard, David, primary

Published
2023
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33. Supplementary Table 1, Figures 1 - 8 from PLA2R1 Mediates Tumor Suppression by Activating JAK2

Author

Vindrieux, David, primary, Augert, Arnaud, primary, Girard, Christophe A., primary, Gitenay, Delphine, primary, Lallet-Daher, Helene, primary, Wiel, Clotilde, primary, Le Calvé, Benjamin, primary, Gras, Baptiste, primary, Ferrand, Mylène, primary, Verbeke, Stéphanie, primary, de Launoit, Yvan, primary, Leroy, Xavier, primary, Puisieux, Alain, primary, Aubert, Sébastien, primary, Perrais, Michael, primary, Gelb, Michael, primary, Simonnet, Hélène, primary, Lambeau, Gérard, primary, and Bernard, David, primary

Published
2023
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36. Formal Proofs of Code Generation and Verification Tools

Author

Leroy, Xavier, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Giannakopoulou, Dimitra, editor, and Salaün, Gwen, editor

Published
2014
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37. Formal C Semantics: CompCert and the C Standard

Author

Krebbers, Robbert, Leroy, Xavier, Wiedijk, Freek, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Klein, Gerwin, editor, and Gamboa, Ruben, editor

Published
2014
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38. MRI accuracy for recurrence after partial gland ablation with HIFU for localized prostate cancer. A systematic review and meta-analysis

Author

Séguier, Denis, Puech, Philippe, Barret, Eric, Leroy, Xavier, Labreuche, Julien, Penna, Raphael Renard, Ploussard, Guillaume, Villers, Arnauld, and Olivier, Jonathan

Abstract

Background: Prostate cancer remains the most frequently diagnosed cancer among men. High-Intensity Focused Ultrasound (HIFU) has emerged as a thermal ablative technique for partial-gland-ablation (PGA), aiming to minimize collateral damage while maximizing tumor control. Monitoring after HIFU PGA relies on serial PSA testing, multiparametric-MRI, and biopsies. The diagnostic accuracy of MRI for clinically-significant cancer(csPCa) recurrence is challenging. Objective: This systematic review and meta-analysis aim to evaluate the accuracy of MRI in detecting early recurrence of localized prostate cancer following HIFU PGA. Methods: Adhering to PRISMA guidelines, a comprehensive literature search was conducted until May 8th2024 using MEDLINE and Scopus. The inclusion criteria encompassed randomized controlled trials and cohort studies involving men diagnosed with localized prostate cancer who had as primary treatment HIFU PGA. The primary outcome measures included the sensitivity, specificity, positive-predictive value (PPV), and negative-predictive value (NPV) of MRI for csPCa(ISUP ≥ 2) based on biopsy results. We pooled data from studies with sufficient csPCa and csPCa-free patients (≥5) post HIFU for statistical analysis. Results: Fifteen studies meet the inclusion criteria, encompassing 1093 patients and 12 studies were eligible for meta-analysis. MRI sensitivity in detecting clinically-significant prostate cancer (csPCa) recurrence post HIFU PGA varied widely (0–89%), with a pooled sensitivity of 0.52 (95% CI:0.36–0.68). Specificity ranged from 44% to 100%, with a pooled specificity of 0.81 (95% CI:0.68–0.91). The pooled NPV was 0.82 (95% CI:0.72–0.90), and the pooled PPV was 0.50 (95% CI:0.35–0.65). Three studies reported in-field diagnostic performance with sensitivities ranging from 0.42 to 0.80 and specificities from 0.45 to 0.97. Conclusion: MRI accuracy for clinically-significant recurrence after partial gland ablation with HIFU for localized prostate cancer shows low diagnostic performance in the treated lobe with pooled sensitivity of 0.52 (95% CI:0.36–0.68) and specificity of 0.81 (95% CI:0.68–0.91). Limits of this review include the low number of studies reporting about site of recurrence in or out of the treated lobe.

Published
2024
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40. 1393 Beyond CCR8 key epitopes targeting dynamic CCR8 conformational states and a diversity of monoclonal antibodies to modulate the tumor microenvironment for the treatment of cancers

Author

Vermot-Desroches, Claudine, primary, Richert, Iseulys, additional, Schappler, Malaury, additional, Dit Maurin, Alice Gentil, additional, Jeannelle, Mégane, additional, Rose, Solène, additional, Baron, Luc, additional, Ruet, Quentin, additional, Dietsch, Camille, additional, Urquia, Pauline, additional, Ayachi, Safia, additional, Blanchard, Orphée, additional, Franchet, Christel, additional, Schann, Stephan, additional, and Leroy, Xavier, additional

Published
2022
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41. The OCaml system release 5.0: Documentation and user's manual

Author

Leroy, Xavier, Doligez, Damien, Frisch, Alain, Garrigue, Jacques, Rémy, Didier, Sivaramakrishnan, Kc, Vouillon, Jérôme, Collège de France - Chaire Sciences du logiciel, Collège de France (CdF (institution)), Langages de programmation : systèmes de types, concurrence, preuve de programme (CAMBIUM), Collège de France (CdF (institution))-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), LexiFi [Boulogne-Billancourt], Graduate School of Mathematics [Nagoya], Nagoya University, Indian Institute of Technology Madras (IIT Madras), Institut de Recherche en Informatique Fondamentale (IRIF (UMR_8243)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Inria

Subjects
[INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL]
Abstract

This manual documents the release 5.0 of the OCaml system. It is organized as follows. Part I, "An introduction to OCaml", gives an overview of the language. Part II, "The OCaml language", is the reference description of the language. Part III, "The OCaml tools", documents the compilers, toplevel system, and programming utilities. Part IV, "The OCaml library", describes the modules provided in the standard library. Part V, “Indexes”, contains an index of all identifiers defined in the standard library, and an index of keywords.

Published
2022

43. A Formally-Verified Alias Analysis

Author

Robert, Valentin, Leroy, Xavier, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Hawblitzel, Chris, editor, and Miller, Dale, editor

Published
2012
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44. Validating LR(1) Parsers

Author

Jourdan, Jacques-Henri, Pottier, François, Leroy, Xavier, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Seidl, Helmut, editor

Published
2012
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45. Validating Register Allocation and Spilling

Author

Rideau, Silvain, Leroy, Xavier, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Gupta, Rajiv, editor

Published
2010
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47. The CompCert C verified compiler: Documentation and user’s manual

Author

Leroy, Xavier, Leroy, Xavier, Chaire Sciences du logiciel, Collège de France (CdF (institution)), Inria, Langages de programmation : systèmes de types, concurrence, preuve de programme (CAMBIUM), Collège de France (CdF (institution))-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and Collège de France - Chaire Sciences du logiciel

Subjects
[INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL], ComputingMilieux_THECOMPUTINGPROFESSION, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, [INFO.INFO-PL] Computer Science [cs]/Programming Languages [cs.PL]
Abstract

This document is the user’s manual for the CompCert C verified compiler. It is organized as follows: Chapter 1 gives an overview of the CompCert C compiler and of the formal verification of compilers. Chapter 2 explains how to install CompCert C. Chapter 3 explains how to use the CompCert C compiler. Chapter 4 explains how to use the CompCert C reference interpreter. Chapter 5 describes the subset of the ISO C99 language that is implemented by CompCert. Chapter 6 describes the supported language extensions: pragmas, attributes, built-in functions.

Published
2022

48. Introduction

Author

Leroy, Xavier, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Leroy, Xavier, editor, and Ohori, Atsushi, editor

Published
1998
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