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3. Economie politique du monde contemporain.: CPGE, Université, Concours

Author

Nicolas Nekourouh, Sina Badiei, Thomas Belaich, Jules Bergeot, Marius Bickhardt, Samuel Bieber, Julie Chiaruzzi, Louis Daumas, Thomas Irace, Pierre Le Brun, Hadrien Le Mer, Paul Mayens, Lucie Rondeau du Noyer, Léa Saint-Raymond and Nicolas Nekourouh, Sina Badiei, Thomas Belaich, Jules Bergeot, Marius Bickhardt, Samuel Bieber, Julie Chiaruzzi, Louis Daumas, Thomas Irace, Pierre Le Brun, Hadrien Le Mer, Paul Mayens, Lucie Rondeau du Noyer, Léa Saint-Raymond

Published
2024

5. Improved Outcomes with Heavy Silicone Oil in Complex Primary Retinal Detachment: A Large Multicenter Matched Cohort Study

Author

Ellabban, Abdallah A., Chandra, Aman, Davies, Andrew, Morris, Andrew H.C., Meireles, Angelina, Casswell, Anthony G., Jalil, Assad, Babar, Atiq, Groenewald, Carl, Goldsmith, Craig, Laidlaw, David Alistair H., Steel, David H., Yorston, David, Vayalambrone, Deepak, Sanchez-Chicharro, Diego, Hughes, Edward H., Herbert, Edward N., Uys, Enslin, Jenkins, Huw, Pearce, Ian A., Masri, Ibrahim, Khan, Imran, Mitrut, Izabela, Paget, James, Park, Jonathan, Smith, Jonathan, Gonzalez-Lopez, Julio J., Balaggan, Kamaljit Sinbgh, Cornish, Kurt Spiteri, Wakely, Laura, Membrey, Luke, Figueroa, Marta S., Crama, Niels, Chua, Paul Y., Sheard, Richard, Hillier, Roxane, Cherubini, Sandro Di Simplicio, Tan, Shi Z., Tarafdar, Sonali, Winder, Stephen, Cochrane, Timothy, Williamson, Tom H., Ivanova, Tsveta, Papastavrou, Vasileios T., Tanner, Vaughan, Forsaa, Vegard, Le Mer, Yannick, and Tzoumas, Nikolaos

Published
2024
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6. The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

Author

Barret, Didier, Albouys, Vincent, Herder, Jan-Willem den, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Svoboda, Jiri, Wilms, Joern, Yamasaki, Noriko, Audard, Marc, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Dauser, Thomas, Decourchelle, Anne, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Hartog, Roland den, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Korpela, Seppo, Macculi, Claudio, Mendez, Mariano, Mitsuda, Kazuhisa, Molendi, Silvano, Pajot, François, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Skup, Konrad, Soucek, Jan, Thibert, Tanguy, Vink, Jacco, Webb, Natalie, Chaoul, Laurence, Raulin, Desi, Simionescu, Aurora, Torrejon, Jose Miguel, Acero, Fabio, Branduardi-Raymont, Graziella, Ettori, Stefano, Finoguenov, Alexis, Grosso, Nicolas, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Nicastro, Fabrizio, Sciortino, Salvatore, Yamaguchi, Hiroya, Beaumont, Sophie, Cucchetti, Edoardo, D’Andrea, Matteo, Eckart, Megan, Ferrando, Philippe, Kammoun, Elias, Lotti, Simone, Mesnager, Jean-Michel, Natalucci, Lorenzo, Peille, Philippe, de Plaa, Jelle, Ardellier, Florence, Argan, Andrea, Bellouard, Elise, Carron, Jérôme, Cavazzuti, Elisabetta, Fiorini, Mauro, Khosropanah, Pourya, Martin, Sylvain, Perry, James, Pinsard, Frederic, Pradines, Alice, Rigano, Manuela, Roelfsema, Peter, Schwander, Denis, Torrioli, Guido, Ullom, Joel, Vera, Isabel, Villegas, Eduardo Medinaceli, Zuchniak, Monika, Brachet, Frank, Cicero, Ugo Lo, Doriese, William, Durkin, Malcom, Fioretti, Valentina, Geoffray, Hervé, Jacques, Lionel, Kirsch, Christian, Smith, Stephen, Adams, Joseph, Gloaguen, Emilie, Hoogeveen, Ruud, van der Hulst, Paul, Kiviranta, Mikko, van der Kuur, Jan, Ledot, Aurélien, van Leeuwen, Bert-Joost, van Loon, Dennis, Lyautey, Bertrand, Parot, Yann, Sakai, Kazuhiro, van Weers, Henk, Abdoelkariem, Shariefa, Adam, Thomas, Adami, Christophe, Aicardi, Corinne, Akamatsu, Hiroki, Alonso, Pablo Eleazar Merino, Amato, Roberta, André, Jérôme, Angelinelli, Matteo, Anon-Cancela, Manuel, Anvar, Shebli, Atienza, Ricardo, Attard, Anthony, Auricchio, Natalia, Balado, Ana, Bancel, Florian, Barusso, Lorenzo Ferrari, Bascuñan, Arturo, Bernard, Vivian, Berrocal, Alicia, Blin, Sylvie, Bonino, Donata, Bonnet, François, Bonny, Patrick, Boorman, Peter, Boreux, Charles, Bounab, Ayoub, Boutelier, Martin, Boyce, Kevin, Brienza, Daniele, Bruijn, Marcel, Bulgarelli, Andrea, Calarco, Simona, Callanan, Paul, Campello, Alberto Prada, Camus, Thierry, Canourgues, Florent, Capobianco, Vito, Cardiel, Nicolas, Castellani, Florent, Cheatom, Oscar, Chervenak, James, Chiarello, Fabio, Clerc, Laurent, Clerc, Nicolas, Cobo, Beatriz, Coeur-Joly, Odile, Coleiro, Alexis, Colonges, Stéphane, Corcione, Leonardo, Coriat, Mickael, Coynel, Alexandre, Cuttaia, Francesco, D’Ai, Antonino, D’anca, Fabio, Dadina, Mauro, Daniel, Christophe, Dauner, Lea, DeNigris, Natalie, Dercksen, Johannes, DiPirro, Michael, Doumayrou, Eric, Dubbeldam, Luc, Dupieux, Michel, Dupourqué, Simon, Durand, Jean Louis, Eckert, Dominique, Eiriz, Valvanera, Ercolani, Eric, Etcheverry, Christophe, Finkbeiner, Fred, Fiocchi, Mariateresa, Fossecave, Hervé, Franssen, Philippe, Frericks, Martin, Gabici, Stefano, Gant, Florent, Gao, Jian-Rong, Gastaldello, Fabio, Genolet, Ludovic, Ghizzardi, Simona, Gil, Ma Angeles Alcacera, Giovannini, Elisa, Godet, Olivier, Gomez-Elvira, Javier, Gonzalez, Raoul, Gonzalez, Manuel, Gottardi, Luciano, Granat, Dolorès, Gros, Michel, Guignard, Nicolas, Hieltjes, Paul, Hurtado, Adolfo Jesús, Irwin, Kent, Jacquey, Christian, Janiuk, Agnieszka, Jaubert, Jean, Jiménez, Maria, Jolly, Antoine, Jourdan, Thierry, Julien, Sabine, Kedziora, Bartosz, Korb, Andrew, Kreykenbohm, Ingo, König, Ole, Langer, Mathieu, Laudet, Philippe, Laurent, Philippe, Laurenza, Monica, Lesrel, Jean, Ligori, Sebastiano, Lorenz, Maximilian, Luminari, Alfredo, Maffei, Bruno, Maisonnave, Océane, Marelli, Lorenzo, Massonet, Didier, Maussang, Irwin, Melchor, Alejandro Gonzalo, Le Mer, Isabelle, Millan, Francisco Javier San, Millerioux, Jean-Pierre, Mineo, Teresa, Minervini, Gabriele, Molin, Alexeï, Monestes, David, Montinaro, Nicola, Mot, Baptiste, Murat, David, Nagayoshi, Kenichiro, Nazé, Yaël, Noguès, Loïc, Pailot, Damien, Panessa, Francesca, Parodi, Luigi, Petit, Pascal, Piconcelli, Enrico, Pinto, Ciro, Plaza, Jose Miguel Encinas, Plaza, Borja, Poyatos, David, Prouvé, Thomas, Ptak, Andy, Puccetti, Simonetta, Puccio, Elena, Ramon, Pascale, Reina, Manuel, Rioland, Guillaume, Rodriguez, Louis, Roig, Anton, Rollet, Bertrand, Roncarelli, Mauro, Roudil, Gilles, Rudnicki, Tomasz, Sanisidro, Julien, Sciortino, Luisa, Silva, Vitor, Sordet, Michael, Soto-Aguilar, Javier, Spizzi, Pierre, Surace, Christian, Sánchez, Miguel Fernández, Taralli, Emanuele, Terrasa, Guilhem, Terrier, Régis, Todaro, Michela, Ubertini, Pietro, Uslenghi, Michela, de Vaate, Jan Geralt Bij, Vaccaro, Davide, Varisco, Salvatore, Varnière, Peggy, Vibert, Laurent, Vidriales, María, Villa, Fabrizio, Vodopivec, Boris Martin, Volpe, Angela, de Vries, Cor, Wakeham, Nicholas, Walmsley, Gavin, Wise, Michael, de Wit, Martin, and Woźniak, Grzegorz

Published
2023
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7. Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial

Author

Alezzandrini, Arturo, Francone, Anibal Andres, Bafalluy, Joaquín, Bainttein, Silvina, Luna Pinto, Jose, Saravia, Mario, Vidosevich, Matko, Zeolite, Carlos, Furno Sola, Federico, Chang, Andrew, Cornish, Elisa Eleanor Guida, Nguyen, Thanh, Findl, Oliver, Haas, Anton, Kralinger, Martina, Sacu, Stefan, Postelmans, Laurence Dominique, Farah, Michel, Maia, Mauricio, Nehemy, Marcio, Ali, Fareed, Brent, Michael, Dollin, Michael, Gonder, John, Kherani, Amin, Merkur, Andrew, Tuli, Raman, Lopera, Monica Marie, Rodriguez, Francisco, Bradvica, Mario, Ernest, Jan, Kalijurand, Kuldar, Noor, Kai, Cohen, Yves, Creuzot-Garcher, Catherine, De Bats, Flore, Devin, François, Français-Maury, Catherine, Kodjikian, Laurent, Korobelnik, Jean François, Le Mer, Yannick, Quaranta El Maftouhi, Maddalena, Razavi, Sam, Souied, Eric, Tadayoni, Ramin, Weber, Michel, Eter, Nicole, Feltgen, Nicolas, Grisanti, Salvatore, Walter, Peter, Liegl, Raffael, Lorenz, Katrin, Spital, Georg, Priglinger, Siegfried, Spitzer, Martin, Volker, Michael, Krohne, Tim, Jochmann, Claudia, Lohmann, Chris Patrick, Framme, Carsten, Kerenyi, Agnes, Papp, Andras, Seres, Andras, Toth-Molnar, Edit, Tsorbatzoglou, Alexis, Vajas, Atilla, Varsanyi, Balázs, Vogt, Gabor, Bar, Asaf, Eting, Eva, Hauser, David, Levy, Jamie, Mathalone, Nurit, Morori-Katz, Haia, Rosenblatt, Irit, Soudry-Zayit, Shiri, Trivizky, Omert, Bandello, Francesco, Ciardella, Antonio Pasquale, Figus, Michele, Giansanti, Fabrizio, Lanzetta, Paolo, Mariotti, Cesare, Mastropasqua, Leonardo, Midena, Edoardo, Parmeggiani, Francesco, Ricci, Federico, Simonelli, Francesca, Staurenghi, Giovanni, Viola, Francesco, Varano, Monica, Laganovska, Guna, Cisiecki, Sławomir, Jedrzejewski, Wojciech, Kaluzny, Jakub, Misiuk-Hojło, Marta, Abengoechea, Santiago, Iribarren, Javier Araiz, Ascaso, Franciso Javier, Cubero, Juan Manuel, Gallego-Pinazo, Roberto, Gomez-Ulla De Irazazabal, Francisco, Mestre, Ignasi Jürgens, Mones I Carilla, Jordi Manel, Montero Moreno, Javier, María Ruiz Moreno, José, Sararols Ramsay, Laura, Garcia Layana, Alfredo, Downey, Louise, Abraham, Prema, Alfaro, Daniel Virgil, Bagheri, Nika, Barbazetto, Irene, Benevento, Joseph, Bernstein, Paul, Bertolucci, George, Bhavsar, Abdhish, Bridges, William, Brooks, Jr, Harold Logan, Brown, Jamin, Brucker, Alexander, Calvo, Charles M., Capone, Antonio, Carlson, John, Chan, Clement, Chang, Emmanuel, Chan-Kai, Brian, Chaudhry, Nauman, Chen, Sanford, Csaky, Karl, Cummings, Howard, Danzig, Carl, Dessouki, Amr, Dyer, David, Eaton, Alexander, Eichenbaum, David, Faber, David, Feldman, Robert, Finnen, Neil, Freeman, William, Frenkel, Ronald, Gonzales, Christine, Gonzalez, Victor, Gross, John, Gupta, Sunil, Hall, Edward, Han, Min-Kyu, Heier, Jeffrey, Hershberger, Vrinda, Higgins, Patrick, Hsu, Jason, Ip, Michael, Jablon, Eric, Jewart, Brian, John, Vishak, Jonisch, Jonathan, Joondeph, Brian, Kay, Christine, Khanani, Arshad, Kokame, Gregg T., Kwun, Robert, Lai, Michael, Lally, David, Laud, Ketan, Lavina, Adrian, Lee, Michael, Lin, Phoebe, Lin, Haijiang, Manoharan, Niranjan, Marcus, Dennis, Martidis, Adam, McCabe, Frank, Nielsen, Jared, Osher, James, Palmer, James, Patel, Sunil, Pearlman, Joel, Perkins, Stephen, Pirouz, Ashkan, Qureshi, Jawad, Randolph, John, Piri, Niloofar, Rosenfeld, Phillip, Saperstein, David, Scartozzi, Richard, Schwartz, Steven, Sharma, Ashish, Sharma, Atul, Sheth, Veeral, Singer, Michael, Spinak, David, Suan, Eric, Tabandeh, Homayoun, Tabassian, Ali, Uchiyama, Eduardo, Varenhorst, Michael, Wagner, Alan, Warrow, David, Wells, III, John, Wong, Robert, Wong, Keye, Wykoff, Charles, Xavier, Samantha, Ysasaga, Edward, Khanani, Arshad M, Patel, Sunil S, Danzig, Carl J, Eichenbaum, David A, Wykoff, Charles C, Heier, Jeffrey S, Lally, David R, Monés, Jordi, Nielsen, Jared S, Sheth, Veeral S, Kaiser, Peter K, Clark, Julie, Zhu, Liansheng, Patel, Hersh, Tang, Justin, Desai, Dhaval, and Jaffe, Glenn J

Published
2023
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8. PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models.

Author

Muqit, Mahiul MK, Hubschman, Jean Pierre, Picaud, Serge, McCreery, Douglas B, van Meurs, Jan C, Hornig, Ralf, Buc, Guillaume, Deterre, Martin, Nouvel-Jaillard, Céline, Bouillet, Elodie, Fovet, Claire-Maelle, Hantraye, Philippe, Sahel, José, Martel, Joseph N, and Le Mer, Yannick

Subjects
Retina, Animals, Cats, Macaca fascicularis, Prostheses and Implants, Safety, Microtechnology, Wireless Technology, General Science & Technology
Abstract

PURPOSE:To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovoltaic wireless microchip in two animal models, and refine these surgical procedures for human trials. METHODS:Cats and Macaca fascicularis primates with healthy retina underwent vitrectomy surgery and were implanted with subretinal wireless photovoltaic microchip at the macula/central retina. The 1.5mm PRIMA chip was initially studied in feline eyes. PRIMA implant (2mm,1.5mm sizes) arrays were studied in primates. Feasibility of subretinal chip implantation was evaluated with a newly-developed surgical technique, with surgical complications and adverse events recorded. RESULTS:The 1.5mm implant was placed in the central retina of 11 feline eyes, with implantation duration 43-106 days. The 1.5mm implant was correctly positioned into central macula of 11 primate eyes, with follow-up periods of minimum 6 weeks (n = 11), 2 years (n = 2), and one eye for 3 years. One primate eye underwent multi-chip 1.5mm implantation using two 1.5mm chips. The 2mm implant was delivered to 4 primate eyes. Optical coherence tomography confirmed correct surgical placement of photovoltaic arrays in the subretinal space in all 26 eyes. Intraoperative complications in primate eyes included retinal tear, macular hole, retinal detachment, and vitreous hemorrhage that resolved spontaneously. Postoperatively, there was no case of significant ocular inflammation in the 1.5mm implant group. CONCLUSIONS:We report subretinal implantation of 1.5mm and 2mm photovoltaic arrays in the central retina of feline and central macula of primate eyes with a low rate of device-related complications. The in vivo PRIMA implantation technique has been developed and refined for use for a 2mm PRIMA implant in ongoing human trials.

Published
2020

13. Simultaneous perception of prosthetic and natural vision in AMD patients

Author

D. Palanker, Y. Le Mer, S. Mohand-Said, and J. A. Sahel

Subjects
Science
Abstract

Atrophic age-related macular degeneration (AMD) results in visual impairment. Here the authors report interim analysis of open-label single group feasibility trial using a wireless photovoltaic subretinal implant in patients with atrophic AMD, and report that the patients exhibited prosthetic visual perception with acuity closely matching the pixel size during the 18-24 month follow-up period.

Published
2022
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16. Improved Outcomes with Heavy Silicone Oil in Complex Primary Retinal Detachment

Author

Tzoumas, Nikolaos, primary, Yorston, David, additional, Laidlaw, David Alistair H., additional, Williamson, Tom H., additional, Steel, David H., additional, Ellabban, Abdallah A., additional, Chandra, Aman, additional, Davies, Andrew, additional, Morris, Andrew H.C., additional, Meireles, Angelina, additional, Casswell, Anthony G., additional, Jalil, Assad, additional, Babar, Atiq, additional, Groenewald, Carl, additional, Goldsmith, Craig, additional, Vayalambrone, Deepak, additional, Sanchez-Chicharro, Diego, additional, Hughes, Edward H., additional, Herbert, Edward N., additional, Uys, Enslin, additional, Jenkins, Huw, additional, Pearce, Ian A., additional, Masri, Ibrahim, additional, Khan, Imran, additional, Mitrut, Izabela, additional, Paget, James, additional, Park, Jonathan, additional, Smith, Jonathan, additional, Gonzalez-Lopez, Julio J., additional, Balaggan, Kamaljit Sinbgh, additional, Cornish, Kurt Spiteri, additional, Wakely, Laura, additional, Membrey, Luke, additional, Figueroa, Marta S., additional, Crama, Niels, additional, Chua, Paul Y., additional, Sheard, Richard, additional, Hillier, Roxane, additional, Cherubini, Sandro Di Simplicio, additional, Tan, Shi Z., additional, Tarafdar, Sonali, additional, Winder, Stephen, additional, Cochrane, Timothy, additional, Ivanova, Tsveta, additional, Papastavrou, Vasileios T., additional, Tanner, Vaughan, additional, Forsaa, Vegard, additional, and Le Mer, Yannick, additional

Published
2023
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18. Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial

Author

Khanani, Arshad M, primary, Patel, Sunil S, additional, Staurenghi, Giovanni, additional, Tadayoni, Ramin, additional, Danzig, Carl J, additional, Eichenbaum, David A, additional, Hsu, Jason, additional, Wykoff, Charles C, additional, Heier, Jeffrey S, additional, Lally, David R, additional, Monés, Jordi, additional, Nielsen, Jared S, additional, Sheth, Veeral S, additional, Kaiser, Peter K, additional, Clark, Julie, additional, Zhu, Liansheng, additional, Patel, Hersh, additional, Tang, Justin, additional, Desai, Dhaval, additional, Jaffe, Glenn J, additional, Alezzandrini, Arturo, additional, Francone, Anibal Andres, additional, Bafalluy, Joaquín, additional, Bainttein, Silvina, additional, Luna Pinto, Jose, additional, Saravia, Mario, additional, Vidosevich, Matko, additional, Zeolite, Carlos, additional, Furno Sola, Federico, additional, Chang, Andrew, additional, Cornish, Elisa Eleanor Guida, additional, Nguyen, Thanh, additional, Findl, Oliver, additional, Haas, Anton, additional, Kralinger, Martina, additional, Sacu, Stefan, additional, Postelmans, Laurence Dominique, additional, Farah, Michel, additional, Maia, Mauricio, additional, Nehemy, Marcio, additional, Ali, Fareed, additional, Brent, Michael, additional, Dollin, Michael, additional, Gonder, John, additional, Kherani, Amin, additional, Merkur, Andrew, additional, Tuli, Raman, additional, Lopera, Monica Marie, additional, Rodriguez, Francisco, additional, Bradvica, Mario, additional, Ernest, Jan, additional, Kalijurand, Kuldar, additional, Noor, Kai, additional, Cohen, Yves, additional, Creuzot-Garcher, Catherine, additional, De Bats, Flore, additional, Devin, François, additional, Français-Maury, Catherine, additional, Kodjikian, Laurent, additional, Korobelnik, Jean François, additional, Le Mer, Yannick, additional, Quaranta El Maftouhi, Maddalena, additional, Razavi, Sam, additional, Souied, Eric, additional, Weber, Michel, additional, Eter, Nicole, additional, Feltgen, Nicolas, additional, Grisanti, Salvatore, additional, Walter, Peter, additional, Liegl, Raffael, additional, Lorenz, Katrin, additional, Spital, Georg, additional, Priglinger, Siegfried, additional, Spitzer, Martin, additional, Volker, Michael, additional, Krohne, Tim, additional, Jochmann, Claudia, additional, Lohmann, Chris Patrick, additional, Framme, Carsten, additional, Kerenyi, Agnes, additional, Papp, Andras, additional, Seres, Andras, additional, Toth-Molnar, Edit, additional, Tsorbatzoglou, Alexis, additional, Vajas, Atilla, additional, Varsanyi, Balázs, additional, Vogt, Gabor, additional, Bar, Asaf, additional, Eting, Eva, additional, Hauser, David, additional, Levy, Jamie, additional, Mathalone, Nurit, additional, Morori-Katz, Haia, additional, Rosenblatt, Irit, additional, Soudry-Zayit, Shiri, additional, Trivizky, Omert, additional, Bandello, Francesco, additional, Ciardella, Antonio Pasquale, additional, Figus, Michele, additional, Giansanti, Fabrizio, additional, Lanzetta, Paolo, additional, Mariotti, Cesare, additional, Mastropasqua, Leonardo, additional, Midena, Edoardo, additional, Parmeggiani, Francesco, additional, Ricci, Federico, additional, Simonelli, Francesca, additional, Viola, Francesco, additional, Varano, Monica, additional, Laganovska, Guna, additional, Cisiecki, Sławomir, additional, Jedrzejewski, Wojciech, additional, Kaluzny, Jakub, additional, Misiuk-Hojło, Marta, additional, Abengoechea, Santiago, additional, Iribarren, Javier Araiz, additional, Ascaso, Franciso Javier, additional, Cubero, Juan Manuel, additional, Gallego-Pinazo, Roberto, additional, Gomez-Ulla De Irazazabal, Francisco, additional, Mestre, Ignasi Jürgens, additional, Mones I Carilla, Jordi Manel, additional, Montero Moreno, Javier, additional, María Ruiz Moreno, José, additional, Sararols Ramsay, Laura, additional, Garcia Layana, Alfredo, additional, Downey, Louise, additional, Abraham, Prema, additional, Alfaro, Daniel Virgil, additional, Bagheri, Nika, additional, Barbazetto, Irene, additional, Benevento, Joseph, additional, Bernstein, Paul, additional, Bertolucci, George, additional, Bhavsar, Abdhish, additional, Bridges, William, additional, Brooks, Jr, Harold Logan, additional, Brown, Jamin, additional, Brucker, Alexander, additional, Calvo, Charles M., additional, Capone, Antonio, additional, Carlson, John, additional, Chan, Clement, additional, Chang, Emmanuel, additional, Chan-Kai, Brian, additional, Chaudhry, Nauman, additional, Chen, Sanford, additional, Csaky, Karl, additional, Cummings, Howard, additional, Danzig, Carl, additional, Dessouki, Amr, additional, Dyer, David, additional, Eaton, Alexander, additional, Eichenbaum, David, additional, Faber, David, additional, Feldman, Robert, additional, Finnen, Neil, additional, Freeman, William, additional, Frenkel, Ronald, additional, Gonzales, Christine, additional, Gonzalez, Victor, additional, Gross, John, additional, Gupta, Sunil, additional, Hall, Edward, additional, Han, Min-Kyu, additional, Heier, Jeffrey, additional, Hershberger, Vrinda, additional, Higgins, Patrick, additional, Ip, Michael, additional, Jablon, Eric, additional, Jewart, Brian, additional, John, Vishak, additional, Jonisch, Jonathan, additional, Joondeph, Brian, additional, Kay, Christine, additional, Khanani, Arshad, additional, Kokame, Gregg T., additional, Kwun, Robert, additional, Lai, Michael, additional, Lally, David, additional, Laud, Ketan, additional, Lavina, Adrian, additional, Lee, Michael, additional, Lin, Phoebe, additional, Lin, Haijiang, additional, Manoharan, Niranjan, additional, Marcus, Dennis, additional, Martidis, Adam, additional, McCabe, Frank, additional, Nielsen, Jared, additional, Osher, James, additional, Palmer, James, additional, Patel, Sunil, additional, Pearlman, Joel, additional, Perkins, Stephen, additional, Pirouz, Ashkan, additional, Qureshi, Jawad, additional, Randolph, John, additional, Piri, Niloofar, additional, Rosenfeld, Phillip, additional, Saperstein, David, additional, Scartozzi, Richard, additional, Schwartz, Steven, additional, Sharma, Ashish, additional, Sharma, Atul, additional, Sheth, Veeral, additional, Singer, Michael, additional, Spinak, David, additional, Suan, Eric, additional, Tabandeh, Homayoun, additional, Tabassian, Ali, additional, Uchiyama, Eduardo, additional, Varenhorst, Michael, additional, Wagner, Alan, additional, Warrow, David, additional, Wells, III, John, additional, Wong, Robert, additional, Wong, Keye, additional, Wykoff, Charles, additional, Xavier, Samantha, additional, and Ysasaga, Edward, additional

Published
2023
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19. Does internal limiting membrane peeling during epiretinal membrane surgery induce microscotomas on microperimetry? Study protocol for PEELING, a randomized controlled clinical trial

Author

Jean-Baptiste Ducloyer, Juliette Ivan, Alexandra Poinas, Olivier Lebreton, Alexandre Bonissent, Paul Fossum, Christelle Volteau, Ramin Tadayoni, Catherine Creuzot-Garchet, Yannick Le Mer, Julien Perol, June Fortin, Anne Chiffoleau, Fanny Billaud, Catherine Ivan, and Michel Weber

Subjects
Idiopathic epiretinal membrane, Internal limiting membrane, Peeling, Microscotomas, Medicine (General), R5-920
Abstract

Abstract Background The epiretinal membrane (ERM) is a degenerative condition associated with age, which can cause loss of vision and/or metamorphopsia. The treatment of symptomatic ERM involves surgical removal including a vitrectomy followed by peeling of the ERM using a microforceps. As the internal limiting membrane (ILM) is adherent to the ERM, it is sometimes removed with it (spontaneous peeling). If ILM remains in place, it can be removed to reduce ERM recurrence. However, it is important to clarify the safety of ILM peeling, while it increases surgical risks and cause histological disorganization of the retina that can lead to microscotomas, may be responsible for definitive visual discomfort. Methods PEELING is a prospective, randomized, controlled, single-blind, and multicentered trial with two parallel arms. This study investigates the benefit/risk ratio of active ILM peeling among individuals undergoing ERM surgery without spontaneous ILM peeling. Randomization is done in the operating room after ERM removal if ILM remains in place. After randomization, the two groups—“active peeling of the ILM” and “no peeling of the ILM”—are compared during a total of three follow-up visits scheduled at month 1, month 6, and month 12. Primary endpoint is the difference in microscotomas before surgery and 6 months after surgery. Patients with spontaneous peeling are not randomized and are included in the ancillary study with the same follow-up visits and the same examinations as the principal study. Relevant inclusion criteria involve individuals aged > 18 years living with idiopathic symptomatic ERM, including pseudophakic patients with transparent posterior capsule or open capsule or lensed patients with age-related cataracts. The calculated sample size corresponds to 53 randomized eyes (one eye/patient) per arm that means 106 randomized eyes (106 randomized patients) in total and a maximum of 222 included patients (116 spontaneous peeling). Discussion ILM peeling is often practiced in ERM surgery to reduce ERM recurrence. It does not impair postoperative visual acuity, but it increases the surgical risks and causes anatomical damages. If active ILM peeling is significantly associated with more microscotomas, it may contraindicate the ILM peeling during primitive idiopathic ERM surgery. Trial registration ClinicalTrials.gov, NCT02146144 . Registered on 22 May 2014. Recruitment is still ongoing.

Published
2020
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20. Management of Patients with Diabetic Macular Edema Switched from Dexamethasone Intravitreal Implant to Fluocinolone Acetonide Intravitreal Implant

Author

Stéphanie Baillif, Pascal Staccini, Michel Weber, Marie-Noëlle Delyfer, Yannick Le Mer, Vincent Gualino, Laurence Collot, Pierre-Yves Merite, Catherine Creuzot-Garcher, Laurent Kodjikian, and Pascale Massin

Subjects
diabetic macular edema, dexamethasone implant, fluocinolone acetonide implant, intravitreal therapy, Pharmacy and materia medica, RS1-441
Abstract

To assess anatomical and functional outcomes after switching from dexamethasone implant (DEXi) to fluocinolone acetonide implant (FAci) in 113 diabetic macular edema eyes, a multicentric retrospective observational study was conducted. Seventy-five eyes (73.5%) were switched 1–8 weeks after their last DEXi. The mean best-corrected visual acuity improved to 59.8 letters at month 4 and remained stable during the follow-up. The mean central macular thickness (CMT) significantly decreased during the follow-up, with a minimum of 320.9 μm at month 3. The baseline CMT was higher in eyes that received the last DEXi >8 weeks versus p < 0.021). After FAci injection, additional treatments were needed in 37 (32.7%) eyes. A longer diabetes duration (p = 0.009), a longer time between the last DEXi and the first FAci (p = 0.035), and a high baseline CMT (p = 0.003) were risk factors for additional treatments. The mean intraocular pressure was 8 weeks before the switch. Switching from DEXi to FAci in DME is effective and safe. A short time between the last DEXi and the first FAci reduced CMT fluctuations and the need for early additional treatments.

Published
2022
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21. Ischemic stroke and retinal artery occlusion after carotid aneurysm embolization

Author

Benjamin Blautain, MD, Igor Leleu, MD, Elyse Jabbour, MD, and Yannick Le Mer, MD

Subjects
Branch retinal artery occlusion, Carotid aneurysm, Cholesterol embolism syndrome, Interventional neuroradiology, Stroke, Ultra-wide field retinal angiography, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

We present the case of a 72-year-old male with a right carotid aneurysm incidentally discovered after an ischemic stroke. After management of the stroke, stent-assisted coil embolization was performed to treat the aneurysm. Two simultaneous and early complications occurred: new ischemic strokes and branch retinal artery occlusions, respectively in the right occipital lobe and in the right eye. Treatment of unruptured carotid aneurysm using stent-assisted coil embolization can lead to severe complications involving both the brain and the retina. Multidisciplinary and close surveillance of patients should be performed to diagnose adverse effects of this endovascular treatment.

Published
2021
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24. Intravitreal 5-Fluorouracil and Heparin to Prevent Proliferative Vitreoretinopathy

Author

Friederike Schaub, Petra Schiller, Robert Hoerster, Daria Kraus, Frank G. Holz, Rainer Guthoff, Hansjürgen Agostini, Martin S. Spitzer, Peter Wiedemann, Albrecht Lommatzsch, Karl T. Boden, Spyridon Dimopoulos, Sebastian Bemme, Svenja Tamm, Mathias Maier, Johann Roider, Philip Enders, Lebriz Altay, Sascha Fauser, Bernd Kirchhof, Andrea Pfeiffer, Sandra Willms, Susanne Binder, Yannik Le Mer, Hartmut Stützer, Klaus-Dieter Lemmen, Ralph Heimke-Brinck, Tobias Borst, Karl Ulrich Bartz-Schmidt, Josep Callizo, Claudia Dahlke, Philipp Eberwein, Christoph Ehlken, Nicolas Feltgen, Andreea Gamulescu, Faik Gelisken, Matthias Gutfleisch, Arno Haus, Horst Helbig, Manuel Hermann, Kai Januschowski, Claudia Jochmann, Tim Krohne, Wolf Lagrèze, Clemens Lange, Chris Lohmann, Marc Andrej Macek, David Märker, Christian Mayer, Petra Meier, Philipp Müther, Philipp Prahs, Konstantine Purtskhvanidze, Matus Rehak, Tina Schick, Steffen Schmitz-Valckenberg, Maximilian Schultheiß, Christos Skevas, Andreas Stahl, Peter Szurman, Jan Darius Unterlauft, Martin Hellmich, and Katrin Kuhr

Subjects
Ophthalmology
Published
2022

25. PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models.

Author

Mahiul M K Muqit, Jean Pierre Hubschman, Serge Picaud, Douglas B McCreery, Jan C van Meurs, Ralf Hornig, Guillaume Buc, Martin Deterre, Céline Nouvel-Jaillard, Elodie Bouillet, Claire-Maelle Fovet, Philippe Hantraye, José Sahel, Joseph N Martel, and Yannick Le Mer

Subjects
Medicine, Science
Abstract

PURPOSE:To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovoltaic wireless microchip in two animal models, and refine these surgical procedures for human trials. METHODS:Cats and Macaca fascicularis primates with healthy retina underwent vitrectomy surgery and were implanted with subretinal wireless photovoltaic microchip at the macula/central retina. The 1.5mm PRIMA chip was initially studied in feline eyes. PRIMA implant (2mm,1.5mm sizes) arrays were studied in primates. Feasibility of subretinal chip implantation was evaluated with a newly-developed surgical technique, with surgical complications and adverse events recorded. RESULTS:The 1.5mm implant was placed in the central retina of 11 feline eyes, with implantation duration 43-106 days. The 1.5mm implant was correctly positioned into central macula of 11 primate eyes, with follow-up periods of minimum 6 weeks (n = 11), 2 years (n = 2), and one eye for 3 years. One primate eye underwent multi-chip 1.5mm implantation using two 1.5mm chips. The 2mm implant was delivered to 4 primate eyes. Optical coherence tomography confirmed correct surgical placement of photovoltaic arrays in the subretinal space in all 26 eyes. Intraoperative complications in primate eyes included retinal tear, macular hole, retinal detachment, and vitreous hemorrhage that resolved spontaneously. Postoperatively, there was no case of significant ocular inflammation in the 1.5mm implant group. CONCLUSIONS:We report subretinal implantation of 1.5mm and 2mm photovoltaic arrays in the central retina of feline and central macula of primate eyes with a low rate of device-related complications. The in vivo PRIMA implantation technique has been developed and refined for use for a 2mm PRIMA implant in ongoing human trials.

Published
2020
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26. Assessment of Spontaneous Retinal Arterial Pulsations in Acute Central Retinal Vein Occlusions

Author

Nicolas Arej, Vivien Vasseur, Elyse Jabbour, Anthony Manassero, Céline Giraud, Sébastien Bruneau, Yannick Le Mer, and Martine Mauget-Faÿsse

Subjects
Ophthalmology, RE1-994
Abstract

Central retinal vein occlusion (CRVO) is a common retinal disease. Recent works mentioned spontaneous retinal arterial pulsations (SRAPs) as a feature of some CRVOs. This is a retrospective study on patients presenting with CRVO who were followed up for at least 6 months. The objective was to identify SRAP in the acute phase of the disease and determine their relationship with patients’ characteristics and visual prognosis. A 10-second infrared film centered on the optic disc was recorded within a month of the onset of symptoms, and SRAPs were detected in two-thirds of the cases. Patients with SRAP were significantly younger than those without SRAP. Mean central macular thickness was significantly higher in the absence of SRAP, which was translated into a more severe macular edema; however, this difference faded with time. BCVA tended to be higher in the presence of SRAP at the 6-month follow-up when adjusted to baseline. This study demonstrates that SRAPs are a frequent finding, easily detected by infrared fundus video recording, and associated with a younger age and lesser macular edema.

Published
2020
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27. The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

Author

Didier Barret, Vincent Albouys, Jan-Willem den Herder, Luigi Piro, Massimo Cappi, Juhani Huovelin, Richard Kelley, J. Miguel Mas-Hesse, Stéphane Paltani, Gregor Rauw, Agata Rozanska, Jiri Svoboda, Joern Wilms, Noriko Yamasaki, Marc Audard, Simon Bandler, Marco Barbera, Xavier Barcons, Enrico Bozzo, Maria Teresa Ceballos, Ivan Charles, Elisa Costantini, Thomas Dauser, Anne Decourchelle, Lionel Duband, Jean-Marc Duval, Fabrizio Fiore, Flavio Gatti, Andrea Goldwurm, Roland den Hartog, Brian Jackson, Peter Jonker, Caroline Kilbourne, Seppo Korpela, Claudio Macculi, Mariano Mendez, Kazuhisa Mitsuda, Silvano Molendi, François Pajot, Etienne Pointecouteau, Frederick Porter, Gabriel W. Pratt, Damien Prêle, Laurent Ravera, Kosuke Sato, Joop Schaye, Keisuke Shinozaki, Konrad Skup, Jan Soucek, Tanguy Thibert, Jacco Vink, Natalie Webb, Laurence Chaoul, Desi Raulin, Aurora Simionescu, Jose Miguel Torrejon, Fabio Acero, Graziella Branduardi-Raymont, Stefano Ettori, Alexis Finoguenov, Nicolas Grosso, Jelle Kaastra, Pasquale Mazzotta, Jon Miller, Giovanni Miniutti, Fabrizio Nicastro, Salvatore Sciortino, Hiroya Yamaguchi, Sophie Beaumont, Edoardo Cucchetti, Matteo D’Andrea, Megan Eckart, Philippe Ferrando, Elias Kammoun, Simone Lotti, Jean-Michel Mesnager, Lorenzo Natalucci, Philippe Peille, Jelle de Plaa, Florence Ardellier, Andrea Argan, Elise Bellouard, Jérôme Carron, Elisabetta Cavazzuti, Mauro Fiorini, Pourya Khosropanah, Sylvain Martin, James Perry, Frederic Pinsard, Alice Pradines, Manuela Rigano, Peter Roelfsema, Denis Schwander, Guido Torrioli, Joel Ullom, Isabel Vera, Eduardo Medinaceli Villegas, Monika Zuchniak, Frank Brachet, Ugo Lo Cicero, William Doriese, Malcom Durkin, Valentina Fioretti, Hervé Geoffray, Lionel Jacques, Christian Kirsch, Stephen Smith, Joseph Adams, Emilie Gloaguen, Ruud Hoogeveen, Paul van der Hulst, Mikko Kiviranta, Jan van der Kuur, Aurélien Ledot, Bert-Joost van Leeuwen, Dennis van Loon, Bertrand Lyautey, Yann Parot, Kazuhiro Sakai, Henk van Weers, Shariefa Abdoelkariem, Thomas Adam, Christophe Adami, Corinne Aicardi, Hiroki Akamatsu, Pablo Eleazar Merino Alonso, Roberta Amato, Jérôme André, Matteo Angelinelli, Manuel Anon-Cancela, Shebli Anvar, Ricardo Atienza, Anthony Attard, Natalia Auricchio, Ana Balado, Florian Bancel, Lorenzo Ferrari Barusso, Arturo Bascuñan, Vivian Bernard, Alicia Berrocal, Sylvie Blin, Donata Bonino, François Bonnet, Patrick Bonny, Peter Boorman, Charles Boreux, Ayoub Bounab, Martin Boutelier, Kevin Boyce, Daniele Brienza, Marcel Bruijn, Andrea Bulgarelli, Simona Calarco, Paul Callanan, Alberto Prada Campello, Thierry Camus, Florent Canourgues, Vito Capobianco, Nicolas Cardiel, Florent Castellani, Oscar Cheatom, James Chervenak, Fabio Chiarello, Laurent Clerc, Nicolas Clerc, Beatriz Cobo, Odile Coeur-Joly, Alexis Coleiro, Stéphane Colonges, Leonardo Corcione, Mickael Coriat, Alexandre Coynel, Francesco Cuttaia, Antonino D’Ai, Fabio D’anca, Mauro Dadina, Christophe Daniel, Lea Dauner, Natalie DeNigris, Johannes Dercksen, Michael DiPirro, Eric Doumayrou, Luc Dubbeldam, Michel Dupieux, Simon Dupourqué, Jean Louis Durand, Dominique Eckert, Valvanera Eiriz, Eric Ercolani, Christophe Etcheverry, Fred Finkbeiner, Mariateresa Fiocchi, Hervé Fossecave, Philippe Franssen, Martin Frericks, Stefano Gabici, Florent Gant, Jian-Rong Gao, Fabio Gastaldello, Ludovic Genolet, Simona Ghizzardi, Ma Angeles Alcacera Gil, Elisa Giovannini, Olivier Godet, Javier Gomez-Elvira, Raoul Gonzalez, Manuel Gonzalez, Luciano Gottardi, Dolorès Granat, Michel Gros, Nicolas Guignard, Paul Hieltjes, Adolfo Jesús Hurtado, Kent Irwin, Christian Jacquey, Agnieszka Janiuk, Jean Jaubert, Maria Jiménez, Antoine Jolly, Thierry Jourdan, Sabine Julien, Bartosz Kedziora, Andrew Korb, Ingo Kreykenbohm, Ole König, Mathieu Langer, Philippe Laudet, Philippe Laurent, Monica Laurenza, Jean Lesrel, Sebastiano Ligori, Maximilian Lorenz, Alfredo Luminari, Bruno Maffei, Océane Maisonnave, Lorenzo Marelli, Didier Massonet, Irwin Maussang, Alejandro Gonzalo Melchor, Isabelle Le Mer, Francisco Javier San Millan, Jean-Pierre Millerioux, Teresa Mineo, Gabriele Minervini, Alexeï Molin, David Monestes, Nicola Montinaro, Baptiste Mot, David Murat, Kenichiro Nagayoshi, Yaël Nazé, Loïc Noguès, Damien Pailot, Francesca Panessa, Luigi Parodi, Pascal Petit, Enrico Piconcelli, Ciro Pinto, Jose Miguel Encinas Plaza, Borja Plaza, David Poyatos, Thomas Prouvé, Andy Ptak, Simonetta Puccetti, Elena Puccio, Pascale Ramon, Manuel Reina, Guillaume Rioland, Louis Rodriguez, Anton Roig, Bertrand Rollet, Mauro Roncarelli, Gilles Roudil, Tomasz Rudnicki, Julien Sanisidro, Luisa Sciortino, Vitor Silva, Michael Sordet, Javier Soto-Aguilar, Pierre Spizzi, Christian Surace, Miguel Fernández Sánchez, Emanuele Taralli, Guilhem Terrasa, Régis Terrier, Michela Todaro, Pietro Ubertini, Michela Uslenghi, Jan Geralt Bij de Vaate, Davide Vaccaro, Salvatore Varisco, Peggy Varnière, Laurent Vibert, María Vidriales, Fabrizio Villa, Boris Martin Vodopivec, Angela Volpe, Cor de Vries, Nicholas Wakeham, Gavin Walmsley, Michael Wise, Martin de Wit, Grzegorz Woźniak, Barret, Didier, Albouys, Vincent, Herder, Jan-Willem den, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Svoboda, Jiri, Wilms, Joern, Yamasaki, Noriko, Audard, Marc, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Dauser, Thoma, Decourchelle, Anne, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Hartog, Roland den, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Korpela, Seppo, Macculi, Claudio, Mendez, Mariano, Mitsuda, Kazuhisa, Molendi, Silvano, Pajot, Françoi, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Skup, Konrad, Soucek, Jan, Thibert, Tanguy, Vink, Jacco, Webb, Natalie, Chaoul, Laurence, Raulin, Desi, Simionescu, Aurora, Torrejon, Jose Miguel, Acero, Fabio, Branduardi-Raymont, Graziella, Ettori, Stefano, Finoguenov, Alexi, Grosso, Nicola, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Nicastro, Fabrizio, Sciortino, Salvatore, Yamaguchi, Hiroya, Beaumont, Sophie, Cucchetti, Edoardo, D’Andrea, Matteo, Eckart, Megan, Ferrando, Philippe, Kammoun, Elia, Lotti, Simone, Mesnager, Jean-Michel, Natalucci, Lorenzo, Peille, Philippe, de Plaa, Jelle, Ardellier, Florence, Argan, Andrea, Bellouard, Elise, Carron, Jérôme, Cavazzuti, Elisabetta, Fiorini, Mauro, Khosropanah, Pourya, Martin, Sylvain, Perry, Jame, Pinsard, Frederic, Pradines, Alice, Rigano, Manuela, Roelfsema, Peter, Schwander, Deni, Torrioli, Guido, Ullom, Joel, Vera, Isabel, Villegas, Eduardo Medinaceli, Zuchniak, Monika, Brachet, Frank, Cicero, Ugo Lo, Doriese, William, Durkin, Malcom, Fioretti, Valentina, Geoffray, Hervé, Jacques, Lionel, Kirsch, Christian, Smith, Stephen, Adams, Joseph, Gloaguen, Emilie, Hoogeveen, Ruud, van der Hulst, Paul, Kiviranta, Mikko, van der Kuur, Jan, Ledot, Aurélien, van Leeuwen, Bert-Joost, van Loon, Denni, Lyautey, Bertrand, Parot, Yann, Sakai, Kazuhiro, van Weers, Henk, Abdoelkariem, Shariefa, Adam, Thoma, Adami, Christophe, Aicardi, Corinne, Akamatsu, Hiroki, Alonso, Pablo Eleazar Merino, Amato, Roberta, André, Jérôme, Angelinelli, Matteo, Anon-Cancela, Manuel, Anvar, Shebli, Atienza, Ricardo, Attard, Anthony, Auricchio, Natalia, Balado, Ana, Bancel, Florian, Barusso, Lorenzo Ferrari, Bascuñan, Arturo, Bernard, Vivian, Berrocal, Alicia, Blin, Sylvie, Bonino, Donata, Bonnet, Françoi, Bonny, Patrick, Boorman, Peter, Boreux, Charle, Bounab, Ayoub, Boutelier, Martin, Boyce, Kevin, Brienza, Daniele, Bruijn, Marcel, Bulgarelli, Andrea, Calarco, Simona, Callanan, Paul, Campello, Alberto Prada, Camus, Thierry, Canourgues, Florent, Capobianco, Vito, Cardiel, Nicola, Castellani, Florent, Cheatom, Oscar, Chervenak, Jame, Chiarello, Fabio, Clerc, Laurent, Clerc, Nicola, Cobo, Beatriz, Coeur-Joly, Odile, Coleiro, Alexi, Colonges, Stéphane, Corcione, Leonardo, Coriat, Mickael, Coynel, Alexandre, Cuttaia, Francesco, D’Ai, Antonino, D’anca, Fabio, Dadina, Mauro, Daniel, Christophe, Dauner, Lea, DeNigris, Natalie, Dercksen, Johanne, DiPirro, Michael, Doumayrou, Eric, Dubbeldam, Luc, Dupieux, Michel, Dupourqué, Simon, Durand, Jean Loui, Eckert, Dominique, Eiriz, Valvanera, Ercolani, Eric, Etcheverry, Christophe, Finkbeiner, Fred, Fiocchi, Mariateresa, Fossecave, Hervé, Franssen, Philippe, Frericks, Martin, Gabici, Stefano, Gant, Florent, Gao, Jian-Rong, Gastaldello, Fabio, Genolet, Ludovic, Ghizzardi, Simona, Gil, Ma Angeles Alcacera, Giovannini, Elisa, Godet, Olivier, Gomez-Elvira, Javier, Gonzalez, Raoul, Gonzalez, Manuel, Gottardi, Luciano, Granat, Dolorè, Gros, Michel, Guignard, Nicola, Hieltjes, Paul, Hurtado, Adolfo Jesú, Irwin, Kent, Jacquey, Christian, Janiuk, Agnieszka, Jaubert, Jean, Jiménez, Maria, Jolly, Antoine, Jourdan, Thierry, Julien, Sabine, Kedziora, Bartosz, Korb, Andrew, Kreykenbohm, Ingo, König, Ole, Langer, Mathieu, Laudet, Philippe, Laurent, Philippe, Laurenza, Monica, Lesrel, Jean, Ligori, Sebastiano, Lorenz, Maximilian, Luminari, Alfredo, Maffei, Bruno, Maisonnave, Océane, Marelli, Lorenzo, Massonet, Didier, Maussang, Irwin, Melchor, Alejandro Gonzalo, Le Mer, Isabelle, Millan, Francisco Javier San, Millerioux, Jean-Pierre, Mineo, Teresa, Minervini, Gabriele, Molin, Alexeï, Monestes, David, Montinaro, Nicola, Mot, Baptiste, Murat, David, Nagayoshi, Kenichiro, Nazé, Yaël, Noguès, Loïc, Pailot, Damien, Panessa, Francesca, Parodi, Luigi, Petit, Pascal, Piconcelli, Enrico, Pinto, Ciro, Plaza, Jose Miguel Encina, Plaza, Borja, Poyatos, David, Prouvé, Thoma, Ptak, Andy, Puccetti, Simonetta, Puccio, Elena, Ramon, Pascale, Reina, Manuel, Rioland, Guillaume, Rodriguez, Loui, Roig, Anton, Rollet, Bertrand, Roncarelli, Mauro, Roudil, Gille, Rudnicki, Tomasz, Sanisidro, Julien, Sciortino, Luisa, Silva, Vitor, Sordet, Michael, Soto-Aguilar, Javier, Spizzi, Pierre, Surace, Christian, Sánchez, Miguel Fernández, Taralli, Emanuele, Terrasa, Guilhem, Terrier, Régi, Todaro, Michela, Ubertini, Pietro, Uslenghi, Michela, de Vaate, Jan Geralt Bij, Vaccaro, Davide, Varisco, Salvatore, Varnière, Peggy, Vibert, Laurent, Vidriales, María, Villa, Fabrizio, Vodopivec, Boris Martin, Volpe, Angela, de Vries, Cor, Wakeham, Nichola, Walmsley, Gavin, Wise, Michael, de Wit, Martin, Woźniak, Grzegorz, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Astronomía y Astrofísica, Agencia Estatal de Investigación (AEI), Ministerio de Ciencia e Innovación (MICINN), Centre National D'Etudes Spatiales (CNES), Agenzia Spaziale Italiana (ASI), European Space Agency (ESA), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), SRON Netherlands Institute for Space Research (SRON), Department of Physics [Helsinki], Falculty of Science [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Institut d'Astrophysique et de Géophysique [Liège], Université de Liège, Centrum Astronomiczne im. M. Kopernika, Warszawa (CAMK), Faculty of Civil Engineering [Prague] (FSV CTU), Czech Technical University in Prague (CTU), Columbia Astrophysics Laboratory (CAL), Columbia University [New York], NASA Goddard Space Flight Center (GSFC), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut d'astrophysique spatiale (IAS), and Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES)

Subjects
X-IFU: The X-ray Integral Field Unit, Cosmology and Nongalactic Astrophysics (astro-ph.CO), The X-ray Integral Field Unit [X-IFU], Solar and stellar astrophysics, FOS: Physical sciences, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Settore FIS/05 - Astronomia E Astrofisica, X-rays, SDG 7 - Affordable and Clean Energy, Instrumentation and Methods for Astrophysics (astro-ph.IM), Solar and Stellar Astrophysics (astro-ph.SR), High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics of Galaxies, Athena: the advanced telescope for high energy astrophysics, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysical phenomena, Space instrumentation, Astrophysics - Solar and Stellar Astrophysics, High energy, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], the advanced telescope for high energy astrophysics [Athena], Athena: the advanced telescope for high energy astrophysics · X-IFU: The X-ray Integral Field Unit · Space instrumentation · X-rays · Observatory, Observatory, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, SDG 12 - Responsible Consumption and Production, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer, studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory, a versatile observatory designed to address the Hot and Energetic Universe science theme, selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), it aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over an hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR, browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters. Finally we briefly discuss on the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, and touch on communication and outreach activities, the consortium organisation, and finally on the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. (abridged)., Comment: 48 pages, 29 figures, Accepted for publication in Experimental Astronomy with minor editing

Published
2023

28. What about Becker?

Author

Blanc, Julie, Hartemann-Piollet, Guillaume, and Le Mer, Hadrien

Published
2017

29. European General Practice Research Network (EGPRN): Abstracts from the EGPRN conference in Riga, Latvia, 11–14 May 2017. Theme: ‘Reducing the risk of chronic diseases in general practice/family medicine’

Author

Ruth Kalda, Vija Silina, Sabine Bayen-Krohn, Nathalie Deruytter, Sven Streit, Marjolein Verschoor, Nicolas Rodondi Bonfim Daiana, Robert A. Burman, Tuz Canan, Claire Collins, Kitanovska Gerasimovska Biljana, Sandra Gintere, Raquel Bravo Gómez, Kath Hoffmann, Tugrul Biyiklioglu, Pavlo Kolesnyk, Enkeleint-Aggelos Mechili, Michael Harris, Yochai Schonmann, O. Bleich, Andre Matalon, Hanny Yeshua, Shlomo Vinker, Judit Prus, Doron S. Comaneshter, Arnon D. Cohen, Amnon Lahad, Ludmila Terjajeva, Iveta Skurule, Jean Yves Le Reste, Ronan Le Mer, Jeremy Derriennic, Michele odorico, Delphine le Goff, Sophie Lalande, Patrice Nabbe, Bernard Le Floch, Alice Billot Grasset, Jean Baptiste Nousbaum, Marie O’Shea, Margo Wrigley, Jim Ryan, Brian Osborne, Jogin Thakore, Donal O. Hanlon, Pearse Finegan, Elina Skuja, Elin Kristina Zackrisson, Ilze Skuja, Stefan Bösner, Jamal Abushi, Norbert Donner-Banzhoff, Erik Stolper, Paul Van Royen, Margje van de Wiel, Loes van Bokhoven, Geert Jan Dinant, Katharina Schmalstieg, Wolfgang Himmel, Eva Hummers, Maxime Pautrat, Catherine Laporte, Jean Pierre Lebeau, Jekaterina Ivanova, Miguel-Angel Muñoz, Helene Vaillant-Roussel, Heidrun Lingner, Jacopo Demurtas, Ana-Luisa Neves, Peter Torsza, Radost Asenova, Zalika Klemenc-Ketis, Liam Glynn, Hayriye Kulbay, José-Maria Verdú, Hava Tabenkin, Melissa Nothnagle, Jeffrey Borkan, Kathrin Schlöszler, Robert Splittgerber, Anne Kühlwind, Ausra Saxvik, Anna Franz, Inger Hagqvist, Stig Rödjer, Göran Bondjers, Marija Petek Šter, Polona Selič, Johannes Hauswaldt, Stephanie Heinemann, Ann Verhoeven, Elke Leuridan, Lieve Peremans, Roy Remmen, Leonard Mada, and Roxana Tilea

Subjects
Medicine (General), R5-920
Published
2017
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31. Does internal limiting membrane peeling during epiretinal membrane surgery induce microscotomas on microperimetry? Study protocol for PEELING, a randomized controlled clinical trial

Author

Ducloyer, Jean-Baptiste, Ivan, Juliette, Poinas, Alexandra, Lebreton, Olivier, Bonissent, Alexandre, Fossum, Paul, Volteau, Christelle, Tadayoni, Ramin, Creuzot-Garchet, Catherine, Le Mer, Yannick, Perol, Julien, Fortin, June, Chiffoleau, Anne, Billaud, Fanny, Ivan, Catherine, and Weber, Michel

Published
2020
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32. Foveal hypoplasia in parents of patients with albinism

Author

R. Lejoyeux, A-S Alonso, J. Lafolie, V. Michaud, E. Lasseaux, V. Vasseur, S. Derrien, M. P. Robert, Y. Le Mer, R. Tadayoni, B. Arveiler, and M. Mauget-Faÿsse

Subjects
Ophthalmology, Pediatrics, Perinatology and Child Health, Genetics (clinical)
Abstract

Albinism is a group of genetic disorders characterized by general skin and retinal hypopigmentation. It is in most cases an autosomal recessive condition. Foveal hypoplasia (FH) is one of the main criteria for the diagnosis of albinism. The aim of this study was to analyze the macular profile of the parents of patients with albinism.This study included a case series of 27 patients with albinism seen in Rothschild Foundation between April 2017 and February 2020. Spectral-domain optical coherence tomography (SD-OCT) and OCT angiography (OCT-A) were performed in every patient when possible and in every available parents. FH was graded according to Thomas' classification based on OCT. Next generation sequencing-based gene panel testing was performed in parents and children when a FH was detected on OCT in a parent.Twenty-seven patients with albinism were examined. Nine parents had FH based on the OCT B-scan (33%). In parents without FH based on the SD-OCT B-scan (67%), OCT-A showed a reduced avascular zone in the deep vascular plexus in 4 parents. Six parents carried variants that could explain their phenotype, including TYR R402Q hypomorphic alleles.This study showed the presence of FH in parents of patients with albinism, and aimed to genetically explain this phenotype.

Published
2022

33. Incidence of macular displacement after rhegmatogenous retinal detachment using ultra-widefield fundus autofluorescence

Author

Guy de Saint Sauveur, Sana Sayadi, Raphaël Lejoyeux, Flore Salviat, Ramin Tadayoni, Sébastien Bruneau, Sophie Bonnin, and Yannick Le Mer

Abstract

Purpose The incidence of retinal displacement after rhegmatogenous retinal detachment (RRD) surgery is variable and its clinical consequences are unclear. The aim of this study was to assess the incidence and clinical features of retinal displacement after RRD surgery by using ultra-widefield (UWF) imaging. Methods Retrospective observational study including all consecutive patients who underwent RRD surgery at the Rothschild Foundation Hospital. Postoperative data included the visual acuity and symptoms of visual impairment. Macular retinal displacement occurrence and its features were assessed and measured by using the autofluorescence images. Results A total of 123 eyes were included. UWF fundus autofluorescence revealed the presence of macular retinal displacement in 14 (11%) eyes. All displacements were inferior, with a mean angle of 3.8°. Patients with and without macular displacement did not differ in postoperative visual acuity. The retinal detachment extent and preoperative macular involvement were not significantly associated with the occurrence of retinal displacement. Conclusion In this representative cohort of eyes that underwent RRD surgery with systematic screening for postoperative retinal displacement by UWF fundus autofluorescence, 11% of eyes experienced an inferior retinal shift. As in other cohorts, the presence of metamorphopsia was not associated with the occurrence of retinal shift.

Published
2023

34. Postsurgical Macular Edema after Rhegmatogenous Retinal Detachment: Risk Factors for Recalcitrance to First-Line Therapy and Long-Term Response to Dexamethasone Intravitreal Implant

Author

Violaine Allou, Laura Trucchi, Yannick Le Mer, Ramin Tadayoni, Aude Couturier, and Soufiane Souissi

Abstract

Objectives: To assess the risk factors for recalcitrance to first-line therapy and the long-term response to dexamethasone intravitreal implant (Ozurdex®) of postsurgical macular edema (PSME) after rhegmatogenous retinal detachment (RRD). Methods: This was a retrospective consecutive cohort study of patients who underwent RRD repair between January 2014 and December 2020 at the Rothschild Foundation Hospital and who experienced PSME with at least 18 months of follow-up. Results: Of the 1 152 patients screened, 36 eyes had a PSME (incidence: 3.1%). The mean follow-up was 45.2 months (18.0-80.5 months). Twenty-five eyes (69.4%) were recalcitrant to first-line therapy and received at least one Ozurdex® (mean number: 2.7 [1-12]). On multivariate analysis, perfluorocarbon liquid (PFCL)-assisted drainage was found to significantly increase the risk of recalcitrance (adjusted odds ratio 8.65; 95% confidence interval 1.97-15.33; p = 0.01). A significant difference in best-corrected visual acuity (BCVA) and central macular thickness (CMT) was found before Ozurdex® and at the last follow-up visit: 0.57 ± 0.47 LogMAR vs. 0.34 ± 0.32 LogMAR (p = 0.02) and 483.0 ± 124.0 µm to 354.6 ± 96.5 µm (p=0.001). The absence of serous retinal detachment and the presence of hyperreflective foci at baseline were negative prognostic factors both for recalcitrance and for response to Ozurdex®. Two patients (8%) experienced hypertony, which was well controlled with hypotonic drops. Conclusion: PSME after RRD is highly recalcitrant. Ozurdex® could be reasonably proposed as a first-line treatment, at least if it occurs after PFLC-assisted drainage, given the favorable benefit/risk ratio in the long term.

Published
2023

35. Gérard Mauger, Avec Bourdieu. Un parcours sociologique

Author

Le Mer, Hadrien

Abstract

L’ouvrage présente avec clarté certains des concepts de la « boîte à outils » bourdieusienne tels que l’habitus, la violence symbolique, les champs, le capital ou encore les classes sociales et propose ainsi « une initiation (certes lacunaire) à un style de pensée » (p. 273). Ce style de pensée est marqué selon Gérard Mauger par deux éléments structurants qui lui paraissent au fondement de la discipline sociologique telle que Bourdieu la pratiquait et telle que les sociologues pourraient la p...

Published
2023

37. Cécile Vigour, Bartolomeo Cappellina, Laurence Dumoulin, Virginie Gautron, La justice en examen, attentes et expériences citoyennes

Author

Le Mer, Hadrien

Abstract

L’ouvrage s’ouvre sur la tribune du journal Le Monde du 23 novembre 2021 signée par 3000 magistrats et dénonçant un dialogue rompu entre la justice et société. Afin de mettre « la justice en examen », l’ouvrage ambitionne de saisir la pluralité des représentations et des expériences citoyennes de la justice. Les autrices se situent dans le sillage de la sociologie de la réception de l’action publique et des travaux sur la conscience du droit – les Legal Consciousness Studies – qui ont pour po...

Published
2023

38. Subretinal Photovoltaic Implant PRIMA Provides Central Vision in Subjects with Geographic Atrophy Due to Age-related Macular Degeneration.

Author

Sahel, José-Alain, Le Mer, Yannick, Holz, Frank G., Martel, Joseph, Olmos de Koo, Lisa, Muqit, Mahi, and Palanker, Daniel

Subjects
*MACULAR degeneration, *PERIPHERAL vision, *VISION disorders, *NEAR infrared radiation, *PHOTOVOLTAIC power systems
Abstract

Age-related macular degeneration is one of the leading causes of irreversible vision loss in ageing populations worldwide. The PRIMA bionic vision system is a photovoltaic substitute for lost photoreceptors that is designed for patients with atrophic dry age-related macular degeneration. The subretinal implant, activated by near-infrared light from augmented-reality glasses, provides central prosthetic vision, perceived simultaneously with peripheral natural vision. This editorial reviews PRIMA’s mode of action, clinical trial data and potential impact on clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Endophthalmitis After Intravitreal Injections: Incidence, Presentation, Management, and Visual Outcome

Author

Berthon, Laurent, Maftouhi, Quaranta-El, Bakhti, Amina, Conrath, John, Le Mer, Yannick, Ramahefasolo, Christiane Besse, Coscas, Florence, Français, Catherine, Grenet, Typhaine, Cohen, Salomon Yves, Uzzan, Joël, Razavi, Sam, Saleh, Maher, Delbosc, Bernard, Chaine, Gilles, Fajnkuchen, Franck, Giocanti, Audrey, Delyfer, Marie-Noëlle, Korobelnik, Jean-François, Querques, Giuseppe, Chevreaud, Olivier, Souied, Eric, Musson, Cécile, Chiquet, Christophe, Fortoul, Vincent, Kodjikian, Laurent, Straub, Morgane, Burillon, Carole, Berrod, Jean-Paul, Baillif, Stéphanie, Girmens, Jean-François, Pérol, Julien, Leveziel, Nicolas, Boissonnot, Michèle, Muraine, Marc, Gaucher, David, Le Lez, Marie-Laure, Pisella, Pierre-Jean, Dossarps, Denis, Bron, Alain M., Koehrer, Philippe, Aho-Glélé, Ludwig S., and Creuzot-Garcher, Catherine

Published
2015
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43. Management of Patients with Diabetic Macular Edema Switched from Dexamethasone Intravitreal Implant to Fluocinolone Acetonide Intravitreal Implant

Author

Baillif, Stéphanie, primary, Staccini, Pascal, additional, Weber, Michel, additional, Delyfer, Marie-Noëlle, additional, Le Mer, Yannick, additional, Gualino, Vincent, additional, Collot, Laurence, additional, Merite, Pierre-Yves, additional, Creuzot-Garcher, Catherine, additional, Kodjikian, Laurent, additional, and Massin, Pascale, additional

Published
2022
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45. Intravitreal 5-Fluorouracil and Heparin to Prevent Proliferative Vitreoretinopathy

Author

Schaub, Friederike, primary, Schiller, Petra, additional, Hoerster, Robert, additional, Kraus, Daria, additional, Holz, Frank G., additional, Guthoff, Rainer, additional, Agostini, Hansjürgen, additional, Spitzer, Martin S., additional, Wiedemann, Peter, additional, Lommatzsch, Albrecht, additional, Boden, Karl T., additional, Dimopoulos, Spyridon, additional, Bemme, Sebastian, additional, Tamm, Svenja, additional, Maier, Mathias, additional, Roider, Johann, additional, Enders, Philip, additional, Altay, Lebriz, additional, Fauser, Sascha, additional, Kirchhof, Bernd, additional, Pfeiffer, Andrea, additional, Willms, Sandra, additional, Binder, Susanne, additional, Le Mer, Yannik, additional, Stützer, Hartmut, additional, Lemmen, Klaus-Dieter, additional, Heimke-Brinck, Ralph, additional, Borst, Tobias, additional, Bartz-Schmidt, Karl Ulrich, additional, Callizo, Josep, additional, Dahlke, Claudia, additional, Eberwein, Philipp, additional, Ehlken, Christoph, additional, Feltgen, Nicolas, additional, Gamulescu, Andreea, additional, Gelisken, Faik, additional, Gutfleisch, Matthias, additional, Haus, Arno, additional, Helbig, Horst, additional, Hermann, Manuel, additional, Januschowski, Kai, additional, Jochmann, Claudia, additional, Krohne, Tim, additional, Lagrèze, Wolf, additional, Lange, Clemens, additional, Lohmann, Chris, additional, Macek, Marc Andrej, additional, Märker, David, additional, Mayer, Christian, additional, Meier, Petra, additional, Müther, Philipp, additional, Prahs, Philipp, additional, Purtskhvanidze, Konstantine, additional, Rehak, Matus, additional, Schaub, Friederike, additional, Schick, Tina, additional, Schmitz-Valckenberg, Steffen, additional, Schultheiß, Maximilian, additional, Skevas, Christos, additional, Stahl, Andreas, additional, Szurman, Peter, additional, Unterlauft, Jan Darius, additional, Hellmich, Martin, additional, and Kuhr, Katrin, additional

Published
2022
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46. Efficacité et tolérance du Latanoprost donné en première intention dans le traitement du glaucome primitif a angle ouvert chez le mélanoderme africain

Author

A. Boro, I. Cochereau, L Traore, F Sidibé, H. Aboubakar, M.-K. Sidibé, J.P. Nordmann, F. Keita, T Nadio, F. Sylla, Y. Le Mer, A Napo, M. Togo, A. Coulibaly, C.F.M. Tounkara, and D. Konaté

Subjects
Gynecology, Ophthalmology, medicine.medical_specialty, business.industry, medicine, business
Abstract

Resume But Evaluer la baisse de la PIO et la symptomatologie oculaire chez les patients nouvellement diagnostiques de GPAO et traites en monotherapie par le Latanoprost. Patients et methodes Il s’est agi d’une etude multicentrique, transversale et descriptive. Nous avons inclus les adultes nouvellement diagnostiques de GPAO. Tous les patients ont recu une goutte de Latanoprost 0,005 % conserve dans chaque œil tous les soirs pendant 12 semaines. La variation de la PIO et l’apparition des signes et symptomes oculaires etaient evalues pendant et a la fin du traitement. Resultats Au total, nous avons inclus 524 patients avec un taux de participation a 93,3 % a 12 semaines. La moyenne d’âge etait de 52,79 ± 17,33 ans et le sexe-ratio H/F etait de 1,39. La PIO moyenne a l’inclusion etait de 21,68 ± 9,72 mmHg. Apres 2 semaines de traitement, la PIO moyenne etait de 15,49 ± 5,81 mmHg, soit une reduction de 28,55 %. Apres 12 semaines de traitement, la PIO moyenne etait de 13,16 ± 3,54 mmHg, soit une reduction de 39,30 %. Les symptomes enregistres etaient domines par la sensation de grains de sable dont la frequence etait de 4,72 % a S2 et 2,45 % a S12. Les signes etaient majoritairement representes par l’hyperhemie conjonctivale (4,33 % a S2 et 1,84 % a S12). Conclusion Le Latanoprost donne en premiere intention et en monotherapie dans le GPAO chez le melanoderme baisse considerablement la PIO. L’incidence des effets indesirables reste faible ; elle est plus importante en debut de traitement.

Published
2021

47. Incidence and clinical significance of fovea plana in the French population with age-related cataract

Author

R Lejoyeux, S Bonnin, D Guindolet, B Jacquiod, O Erol, Y Le Mer, H Jeguirim, M Mauget-Faÿsse, and R Tadayoni

Subjects
Ophthalmology, General Medicine
Abstract

Background Fovea plana is defined as an immature macula diagnosed by OCT, showing the unusual shunt of the inner retinal layers into the fovea. The incidence of fovea plana in the adult population remains to be determined. The aim of this study was to determine the incidence of fovea plana in the French population with age-related cataract. Methods Consecutive patients who underwent cataract surgery in Rothschild Foundation Hospital, France, between January and March 2021, with preoperative analyzable OCT scans available, were retrospectively screened in order to determine the incidence of fovea plana in these population. Ophthalmological characteristics of patients were reported, and detailed. Result Fovea plana was encountered in 20 out of 204 patients during the 3 months corresponding to an incidence of 9.8%. One of those patients had stage 2 fovea plana. Conclusion Although fovea plana is defined as an immature macula, it is not rare in preoperative population. This macular aspect was not associated with poor visual acuity in our cohort.

Published
2022

48. Exploring the control of earthworm cast macro- and micro-scale features on soil organic carbon mineralization across species and ecological categories

Author

Guillaume Le Mer, Nicolas Bottinelli, Marie-France Dignac, Yvan Capowiez, Pascal Jouquet, Arnaud Mazurier, François Baudin, Laurent Caner, Cornelia Rumpel, Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut d'écologie et des sciences de l'environnement de Paris (iEES), Institut National de la Recherche Agronomique (INRA)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de la Terre de Paris (iSTeP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ANR-20-CE01-0015,U2WORM,Comprendre et utiliser les services écosystémiques fournis par les vers de terre(2020), and Dignac, Marie-France

Subjects
[SDE.BE] Environmental Sciences/Biodiversity and Ecology, Cast features, Earthworm, Soil Science, C mineralization, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Microstructure, Physical protection
Abstract

The role of earthworms on biogeochemical carbon cycling is a major knowledge gap resulting from the difficulty of isolating and exploring the effects provided by the diversity of organisms. In this study, we investigated the effect of six earthworm species belonging to three ecological categories on soil organic carbon (SOC) mineralisation. To this end, we produced casts with the six species using subsoil material with low SOC content and miscanthus litter. Cast were subjected to laboratory ageing for 140 days. During this process, we monitored physicochemical parameters, CO2 emissions and determined the micro-scale organisation of the casts’ particulate organic matter and pores using X-ray tomography.Our results showed contrasting properties of fresh casts from the 3 main ecological categories, in accordance with the earthworm species’ morphological or behavioral strategies, indicating that those were maintained in artificial environments. However, species-specific changes in cast properties throughout ageing increased intragroup variability among ecological categories. As a result we observed earthworm species-specific evolution of CO2 mineralisation rates during casts ageing. We found that at least half of the variability in CO2 emissions was explained by cast microstructural changes, related to the spatial arrangement between particulate organic matter, porosity, and mineral particles. We conclude that earthworm species-specific traits may play a role in organic carbon protection through their impact on microstructural cast properties.

Published
2022

49. Didier Fassin (dir.), Vies invisibles, morts indicibles

Author

Le Mer, Hadrien

Abstract

La mort de personnes qui ont été invisibilisées toute leur vie suscite peu d’émoi : il y a des morts sociales qui préparent des morts physiques. Face à ce phénomène, la recherche a besoin de retrouver une capacité à s’émouvoir, et de renoncer à une posture de neutralité qui a trop de points communs avec l’indifférence générale. Cet ouvrage rassemble, sous la direction de Didier Fassin, des contributions qui analysent l’inégale visibilité des vivants et des défunts à partir d’un constat collec...

Published
2022

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