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1. Blood neurofilament light chain and S100B as biomarkers of neurological involvement and functional prognosis in COVID-19: a multicenter study

Author

Bisulli, Francesca, Muccioli, Lorenzo, Taruffi, Lisa, Bedin, Roberta, Felici, Silvia, Zenesini, Corrado, Baccari, Flavia, Gentile, Mauro, Orlandi, Niccolò, Rossi, Simone, Nicodemo, Marianna, d’Achille, Fabio, Viale, Pierluigi, Zaccaroni, Stefania, Lodi, Raffaele, Liguori, Rocco, Zini, Andrea, Guarino, Maria, Cortelli, Pietro, Lazzarotto, Tiziana, Janigro, Damir, and Meletti, Stefano

Published
2025
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3. Epidemiological impact of human adenovirus as causative agent of respiratory infections: An Italian multicentre retrospective study, 2022–2023

Author

Giardina, Federica A.M., Pellegrinelli, Laura, Novazzi, Federica, Vian, Elisa, Biscaro, Valeria, Russo, Cristina, Ranno, Stefania, Pagani, Elisabetta, Masi, Elisa, Tiberio, Claudia, Esposito, Martina, Uceda Renteria, Sara, Callegaro, Annapaola, Piccirilli, Giulia, Lazzarotto, Tiziana, Rovida, Francesca, Galli, Cristina, Lalle, Eleonora, Maggi, Fabrizio, Mancini, Nicasio, Acciarri, Carla, Menzo, Stefano, Colacicco, Anna Maria, Scarasciulli, Maria, Piralla, Antonio, Baldanti, Fausto, and Pariani, Elena

Published
2024
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5. Epidemiological characteristics of non-polio enteroviruses in respiratory infections: An Italian multicentre retrospective study, 2022–2023

Author

Ferrari, Guglielmo, Galli, Cristina, Valzano, Antonia, Giacomel, Giovanni, Giacobazzi, Elisabetta, Incrocci, Elisabetta Maria, Gabrielli, Liliana, Franceschiello, Martina, Bordi, Licia, Valli, Beatrice, Genoni, Angelo, Ferrante, Francesco Drago, Acciarri, Carla, Nappo, Francesco, D’Auria, Giovanni, Trentadue, Anna, Coltella, Luana, Linardos, Giulia, Pierangeli, Alessandra, Antonelli, Guido, Scalia, Guido, Palermo, Ilenia, Mauro, Maria Vittoria, Ferreri, Monica Lucia, Pellegrinelli, Laura, Giardina, Federica A.M., Novazzi, Federica, Vian, Elisa, Biscaro, Valeria, Russo, Cristina, Ranno, Stefania, Renteria, Sara Uceda, Callegaro, Annapaola, Pagani, Elisabetta, Masi, Elisa, Tiberio, Claudia, Esposito, Martina, Marinelli, Katia, Menzo, Stefano, Binda, Sandro, Rovida, Francesca, Mancini, Nicasio, Colacicco, Anna Maria, Scarasciulli, Maria, Lalle, Eleonora, Maggi, Fabrizio, Piccirilli, Giulia, Lazzarotto, Tiziana, Piralla, Antonio, Baldanti, Fausto, and Pariani, Elena

Published
2025
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7. Multicenter epidemiological investigation and genetic characterization of respiratory syncytial virus and metapneumovirus infections in the pre-pandemic 2018–2019 season in northern and central Italy

Author

Pierangeli, Alessandra, Piralla, Antonio, Uceda Renteria, Sara, Giacomel, Giovanni, Lunghi, Giovanna, Pagani, Elisabetta, Giacobazzi, Elisabetta, Vian, Elisa, Biscaro, Valeria, Piccirilli, Giulia, Lazzarotto, Tiziana, Menzo, Stefano, Ferreri, Monica Lucia, Novazzi, Federica, Petrarca, Laura, Licari, Amelia, Ferrari, Guglielmo, Oliveto, Giuseppe, Antonelli, Guido, Binda, Sandro, Galli, Cristina, Pellegrinelli, Laura, Pariani, Elena, and Baldanti, Fausto

Published
2023
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8. Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI)

Author

Leruez-Ville, Marianne, Chatzakis, Christos, Lilleri, Daniele, Blazquez-Gamero, Daniel, Alarcon, Ana, Bourgon, Nicolas, Foulon, Ina, Fourgeaud, Jacques, Gonce, Anna, Jones, Christine E., Klapper, Paul, Krom, André, Lazzarotto, Tiziana, Lyall, Hermione, Paixao, Paulo, Papaevangelou, Vassiliki, Puchhammer, Elisabeth, Sourvinos, George, Vallely, Pamela, Ville, Yves, and Vossen, Ann

Published
2024
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13. Treatment with valacyclovir during pregnancy for prevention of congenital cytomegalovirus infection: a real-life multicenter Italian observational study

Author

Zammarchi, Lorenzo, Tomasoni, Lina Rachele, Liuzzi, Giuseppina, Simonazzi, Giuliana, Dionisi, Camilla, Mazzarelli, Laura Letizia, Seidenari, Anna, Maruotti, Giuseppe Maria, Ornaghi, Sara, Castelli, Francesco, Abbate, Isabella, Bordi, Licia, Mazzotta, Stefania, Fusco, Paolo, Torti, Carlo, Calò Carducci, Francesca Ippolita, Baccini, Michela, Modi, Giulia, Galli, Luisa, Lilleri, Daniele, Furione, Milena, Zavattoni, Maurizio, Ricciardi, Alessandra, Arossa, Alessia, Vimercati, Antonella, Lovatti, Sofia, Salomè, Serena, Raimondi, Francesco, Sarno, Laura, Sforza, Anita, Fichera, Anna, Caforio, Leonardo, Trotta, Michele, and Lazzarotto, Tiziana

Published
2023
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14. Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Author

Pinho Guedes, Mariana Nunes, Maccarrone, Gaia, Pezzani, Maria Diletta, Sibani, Marcella, Davies, Ruth Joanna, Vitali, Stefania, Franchina, Giorgia, Tomassini, Giorgia, Sciammarella, Concetta, Cecchetto, Riccardo, Gibellini, Davide, De Toffoli, Chiara Konishi, Rosini, Giulia, Perlini, Chiara, Meroi, Marco, Cioli Puviani, Filippo, Fasan, Daniele, Micheletto, Claudio, Montemezzi, Stefania, Cardobi, Nicolò, Vantini, Gianluca, Mazzali, Gloria, Stabile, Giovanni, Marcanti, Maddalena, Zonta, Marco Pattaro, Calì, Deborah, Mason, Anna, Perlini, Cinzia, Gisondi, Paolo, Mongardi, Maria, Sorbello, Simona, Wold, Karin I., Vincenti-González, María F., Veloo, Alida C.M., Harmsma, Valerie P.R., Pantano, Daniele, van der Meer, Margriet, Gard, Lilli, Lizarazo, Erley F., Knoester, Marjolein, Friedrich, Alex W., Niesters, Hubert G.M., Viale, Pierluigi, Marzolla, Domenico, Cosentino, Federica, Di Chiara, Michela, Fornaro, Giacomo, Bonazzetti, Cecilia, Tazza, Beatrice, Toschi, Alice, Vetamanu, Oana, Giacomini, Maria Eugenia, Trapani, Fabio, Marconi, Lorenzo, Attard, Luciano, Tedeschi, Sara, Gabrielli, Liliana, Lazzarotto, Tiziana, Olivares, Paula, Castilla, Javier, Vélez, Javier, Almadana, Virginia, Martín-Barrera, Lucía, Martín-Gutiérrez, Ana Belén, Gutiérrez-Campos, David, Fernández-Regaña, Marta, Silva-Campos, Ana, Fernández-Riejos, Patricia, García-Sánchez, M. Isabel, Giuliano, Carla V., López, Carlota, Neumann, Gabriela, Camporro, Julieta, de Vedia, Lautaro, Agugliaro, Hugo, Scipione, Gabriella, Dellacasa, Chiara, Chandramouli, Balasubramanian, Gioiosa, Silvia, Naranjo, Juan Mata, Ortali, Maurizio, Konnova, Angelina, Gupta, Akshita, Smet, Mathias, Hotterbeekx, An, Berkell, Matilda, Sicuri, Elisa, Bachelet, Delphine, Bouadma, Lila, Cervantes-Gonzalez, Minerva, Chair, Anissa, Charpentier, Charlotte, Chenard, Léo, Descamps, Diane, Doan, Hang, Duval, Xavier, Esposito-Farese, Marina, Hoffmann, Isabelle, Kafif, Ouifiya, Le Hingrat, Quentin, Letrou, Sophie, Mentré, France, Schneider, Marion, Tardivon, Coralie, Timsit, Jean-Francois, Tubiana, Sarah, Abrous, Amal, Couffin-Cadiergues, Sandrine, Da Silva, Fernanda Dias, Esperou, Hélène, Houas, Ikram, Jaafoura, Salma, Papadopoulos, Aurélie, Ansart, Severine, Auvet, Adrien, Bani-Sadr, Firouzé, Bernard, L., Bissuel, François, Botelho-Nevers, Elisabeth, Bouhour, Damien, Cabié, André, Caraux Paz, Pauline, Chidiac, Christian, Chirouze, Catherine, Chroboczek, Tomasz, Cordel, Hugues, Courtois, Roxane, De Castro, Nathalie, Diamamntis, Sylvain, Diehl, Jean-Luc, Djossou, Felix, Dorival, Céline, Epaulard, Olivier, Gaborieau, Valerie, Goehringer, François, Gousseff, Marie, Jamard, Simon, Joseph, Cedric, Lacombe, Karine, Le Mestre, Soizic, Le Moing, Vincent, Lelievre, Jean-Daniel, Lesens, Olivier, Machado, M., Maillet, Mylène, Manda, Victoria, Martin-Blondel, Guillaume, Martinot, Martin, Meysonnier, Vanina, Molina, Jean-Michel, Oziol, Eric, Pestre, Vincent, Piroth, Lionel, Poissy, Julien, Rabaud, Christian, Raffi, François, Rammaert, Blandine, Rapp, Christophe, Rebaudet, Stanislas, Roger, Pierre-Marie, Roux, Damien, Senneville, Eric, Tattevin, Pierre, Wiedemann, Aurélie, Zucman, David, Gentilotti, Elisa, Górska, Anna, Tami, Adriana, Gusinow, Roy, Mirandola, Massimo, Rodríguez Baño, Jesús, Palacios Baena, Zaira R., Rossi, Elisa, Hasenauer, Jan, Lopes-Rafegas, Iris, Righi, Elda, Caroccia, Natascia, Cataudella, Salvatore, Pasquini, Zeno, Osmo, Thomas, Del Piccolo, Lidia, Savoldi, Alessia, Kumar-Singh, Samir, Mazzaferri, Fulvia, Caponcello, Maria Giulia, de Boer, Gerolf, Hara, Gabriel Levy, De Nardo, Pasquale, Malhotra, Surbhi, Canziani, Lorenzo Maria, Ghosn, Jade, Florence, Aline-Marie, Lafhej, Nadhem, van der Gun, Bernardina T.F., Giannella, Maddalena, Laouénan, Cédric, and Tacconelli, Evelina

Published
2023
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16. Effectiveness of high‐dose esomeprazole or pantoprazole 10‐day sequential therapy empirically prescribed in Helicobacter pylori‐infected naïve patients: a retrospective study.

Author

Pavoni, Matteo, Fiorini, Giulia, Zullo, Angelo, Saracino, Ilaria Maria, Gatta, Luigi, Manta, Raffaele, Imbrogno, Andrea, Lazzarotto, Tiziana, Borghi, Claudio, and Vaira, Dino

Subjects
HELICOBACTER pylori infections, HELICOBACTER pylori, BACTERIAL diseases, TERRESTRIAL radiation, MULTIVARIATE analysis
Abstract

Background and Aim: Helicobacter pylori infection is one of the most common bacterial infections affecting humans, causing gastroduodenal and extraintestinal diseases. Treatment of the infection remains challenging for the clinicians, and different factors are involved in the failure of the therapeutic approach. The importance of the intensity of acid secretion inhibition remains an unclear issue. The aim of this study is to assess whether 80 mg/day esomeprazole‐based 10‐day sequential therapy (esomeprazole‐ST) achieved different eradication rates when compared to 80 mg/day pantoprazole‐based analogous regimen (pantoprazole‐ST). Methods: This was a retrospective observational study where data of consecutive patients referred by their physicians to our unit to perform an upper gastrointestinal endoscopy were analyzed. Results: Overall, 1,327 patients were available for the analysis: 599 and 728 patients received pantoprazole‐ST and esomeprazole‐ST, respectively. Eradication rate was significantly higher in patients receiving esomeprazole‐ST (92.6%, 95% CI: 91–94.5) than pantoprazole‐ST (89.3%, 95% CI: 86.7–91.7; difference: 3.3%; 95% CI: 0.2–6.5; P = 0.037). Even after a multivariate analysis, the esomeprazole‐ST achieved a significantly higher eradiation (OR: 1.44; 95% CI: 1.1–2.17). Conclusions: This study showed that esomeprazole‐ST achieved significantly higher H. pylori cure rates than pantoprazole‐ST. Prospective and well‐designed trials are demander to confirm this prelaminar finding. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Sanitary Waters: Is It Worth Looking for Mycobacteria?

Author

Cannas, Angela, Messina, Francesco, Dal Monte, Paola, Bisognin, Francesco, Dirani, Giorgio, Zannoli, Silvia, Gatti, Giulia, Butera, Ornella, Ferraro, Vincenzo, Nisii, Carla, Vecchi, Elena, Mattei, Giovanna, Diegoli, Giuseppe, Santoro, Antonio, Belloli, Gian Luigi, Girardi, Enrico, Lazzarotto, Tiziana, Sambri, Vittorio, and Fontana, Carla

Subjects
WHOLE genome sequencing, GENETIC variation, INFECTION control, MYCOBACTERIA, MYCOBACTERIUM
Abstract

The freshwater environment is suitable for nontuberculous mycobacteria (NTMs) growth. Their high adaptability represents a considerable risk for sanitary water systems, which are a potential vector for NTMs transmission. This study investigated the occurrence of NTMs, such as Mycobacterium saskatchewanense, in hospital water systems to support the surveillance and control of potentially pathogenic NTMs. We analyzed 722 ultrapure dialysis fluid samples from Emilia Romagna Dialysis Services. Among these, 35 samples were found to be positive for M. saskatchewanense. The strains were characterized using whole-genome sequencing (WGS) and variability analysis was carried out along the whole M. saskatchewanense genome. This investigation revealed the exclusive presence of M. saskatchewanense in these dialysis machines, with low genetic variability among all strains (with a low number of different alleles: <15). The strong similarity among the strain groups was also confirmed in the WGS-based ML tree, with very few significant nodes, and no clusters were identified. This research highlights the necessity of implementing surveillance protocols and investigating any potential link to human infections, as well as stressing the urgency of enhancing surveillance and infection control measures. [ABSTRACT FROM AUTHOR]

Published
2024
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24. CMV-RNAemia as new marker of active viral replication in transplant recipients

Author

Piccirilli, Giulia, primary, Lanna, Federica, additional, Gabrielli, Liliana, additional, Motta, Vincenzo, additional, Franceschiello, Martina, additional, Cantiani, Alessia, additional, Pavoni, Matteo, additional, Leone, Marta, additional, Borgatti, Eva Caterina, additional, Gibertoni, Dino, additional, Pascale, Renato, additional, Giannella, Maddalena, additional, Bonifazi, Francesca, additional, and Lazzarotto, Tiziana, additional

Published
2024
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26. Using machine learning to predict antibody response to SARS-CoV-2 vaccination in solid organ transplant recipients: the multicentre ORCHESTRA cohort

Author

Giannella, Maddalena, Huth, Manuel, Righi, Elda, Hasenauer, Jan, Marconi, Lorenzo, Konnova, Angelina, Gupta, Akshita, Hotterbeekx, An, Berkell, Matilda, Palacios-Baena, Zaira R., Morelli, Maria Cristina, Tamè, Mariarosa, Busutti, Marco, Potena, Luciano, Salvaterra, Elena, Feltrin, Giuseppe, Gerosa, Gino, Furian, Lucrezia, Burra, Patrizia, Piano, Salvatore, Cillo, Umberto, Cananzi, Mara, Loy, Monica, Zaza, Gianluigi, Onorati, Francesco, Carraro, Amedeo, Gastaldon, Fiorella, Nordio, Maurizio, Kumar-Singh, Samir, Baño, Jesús Rodríguez, Lazzarotto, Tiziana, Viale, Pierluigi, and Tacconelli, Evelina

Published
2023
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30. Mollaret's Meningitis due to Herpes Simplex Virus 2: A Case Report and Review of the Literature.

Author

Gabrielli, Liliana, Banchini, Isabella, Petrisli, Evangelia, Piccirilli, Giulia, Venturoli, Simona, Pavoni, Matteo, Cantiani, Alessia, Lanna, Federica, Campoli, Caterina, Montironi, Matteo, Giannella, Maddalena, and Lazzarotto, Tiziana

Subjects
HUMAN herpesvirus 2, LITERATURE reviews, NEUROLOGICAL disorders, CEREBROSPINAL fluid, MENINGITIS, FEVER, CEREBROSPINAL fluid examination
Abstract

Mollaret's meningitis is a rare neurological disorder characterized by recurrent episodes of aseptic lymphocytic meningitis, often associated with herpes simplex virus 2 (HSV-2) infection. We report the case of a 39 y.o. Italian woman who experienced four episodes of aseptic lymphocytic meningitis between 2004 and 2023, diagnosed as Mollaret's meningitis. In each episode, the patient presented with fever, severe headache and photophobia. In two episodes cutaneous vesicles in the left gluteal area preceding meningitis symptoms were also reported. A diagnostic evaluation included a physical–chemical analysis and a real-time PCR of the cerebrospinal fluid (CSF). The CSF presented pleocytosis with lymphocytic predominance and a positive HSV-2 load, with a peak of 1234 copies/mL. The patient was treated successfully with acyclovir, and the symptoms resolved without neurological sequelae. This case highlights the importance of comprehensive diagnostic testing and vigilant monitoring to manage Mollaret's syndrome effectively. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Efficacy of the Combined Intrastromal Injection of Voriconazole and Amphotericin B in Recalcitrant Fungal Keratitis.

Author

Moramarco, Antonio, Grendele, Arianna, Iannetta, Danilo, Ottoboni, Simone, Gregori, Giulia, di Geronimo, Natalie, Ortalli, Margherita, Lazzarotto, Tiziana, and Fontana, Luigi

Subjects
FUNGAL keratitis, AMPHOTERICIN B, VORICONAZOLE, DISEASE relapse, VISUAL acuity, CANDIDA, ARACHNOID cysts, ANTIFUNGAL agents
Abstract

This study aims to report the efficacy of a combined intrastromal injection in optimizing the outcome of severe mycotic keratitis. Herein, we report a case series of 20 consecutive patients with positive fungal cultures not responding to topical antifungal treatment. Patients received cycles of intrastromal injections of voriconazole (50 µg/0.1 mL) and amphotericin B (2.5 µg/0.1 mL); all patients continued their topical antifungal therapy. The organisms isolated were Fusarium (n = 5), Aspergillus (n = 4), Candida (n = 4), Rhodotorula (n = 2), Penicillium (n = 2), Alternaria (n = 1), Bipolaris (n = 1), and Curvularia (n = 1). The size of the infiltrate varied from 6.5 to 1.5 mm. At presentation, the best corrected visual acuity (BCVA, namely, the best visual acuity achieved with glasses, if needed) was less than 20/400 in all patients, improving to better than 20/400 in eleven patients. Seven patients required surgical intervention; four of them underwent penetrating keratoplasty (PK) à chaud one month after the first intrastromal injection. Patients who underwent surgery achieved a BCVA of 20/40 or better. Combined intrastromal injections before therapeutic penetrating keratoplasty (TPK) effectively reduced ulcer size and graft diameter, preventing infection recurrence. Our results highlight the efficacy of combined intrastromal injections in optimizing outcomes for severe mycotic keratitis undergoing TPK. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Longitudinal Changes of Ocular Surface Microbiome in Patients Undergoing Hemopoietic Stem Cell Transplant (HSCT)

Author

Clougher, Suzanne, primary, Severgnini, Marco, additional, Marangoni, Antonella, additional, Consolandi, Clarissa, additional, Camboni, Tania, additional, Morselli, Sara, additional, Arpinati, Mario, additional, Bonifazi, Francesca, additional, Dicataldo, Michele, additional, Lazzarotto, Tiziana, additional, Fontana, Luigi, additional, and Versura, Piera, additional

Published
2023
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36. Low-Dose Anti-T Lymphoglobulin as Prophylaxis for Graft-versus-Host Disease in Unrelated Donor Transplantations for Acute Leukemias and Myelodysplastic Syndromes

Author

Bonifazi, Francesca, Olivieri, Jacopo, Sessa, Mariarosaria, Dan, Elisa, Sinigaglia, Barbara, Rizzi, Simonetta, Motta, Maria Rosa, Bontadini, Andrea, Ulbar, Francesca, Giudice, Valeria, Papayannidis, Cristina, Curti, Antonio, Chiereghin, Angela, Lazzarotto, Tiziana, Cavo, Michele, and Arpinati, Mario

Published
2018
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37. Cytomegalovirus and Epstein-Barr Virus DNA Kinetics in Whole Blood and Plasma of Allogeneic Hematopoietic Stem Cell Transplantation Recipients

Author

Lazzarotto, Tiziana, Chiereghin, Angela, Piralla, Antonio, Piccirilli, Giulia, Girello, Alessia, Campanini, Giulia, Gabrielli, Liliana, Costa, Cristina, Prete, Arcangelo, Bonifazi, Francesca, Busca, Alessandro, Cairoli, Roberto, Colombo, Anna Amelia, Zecca, Marco, Sidoti, Francesca, Bianco, Gabriele, Paba, Pierpaolo, Perno, Carlo Federico, Cavallo, Rossana, and Baldanti, Fausto

Published
2018
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39. Corrigendum to “Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI)” [The Lancet Regional Health – Europe 40 (2024) 100892]

Author

Leruez-Ville, Marianne, Chatzakis, Christos, Lilleri, Daniele, Blazquez-Gamero, Daniel, Alarcon, Ana, Bourgon, Nicolas, Foulon, Ina, Fourgeaud, Jacques, Gonce, Anna, Jones, Christine E., Klapper, Paul, Krom, André, Lazzarotto, Tiziana, Lyall, Hermione, Paixao, Paulo, Papaevangelou, Vassiliki, Puchhammer, Elisabeth, Sourvinos, George, Vallely, Pamela, Ville, Yves, and Vossen, Ann

Published
2024
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41. Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project

Author

Leomanni, Ludovica, primary, Collatuzzo, Giulia, additional, Sansone, Emanuele, additional, Sala, Emma, additional, De Palma, Giuseppe, additional, Porru, Stefano, additional, Spiteri, Gianluca, additional, Monaco, Maria Grazia Lourdes, additional, Basso, Daniela, additional, Pavanello, Sofia, additional, Scapellato, Maria Luisa, additional, Larese Filon, Francesca, additional, Cegolon, Luca, additional, Mauro, Marcella, additional, Lodi, Vittorio, additional, Lazzarotto, Tiziana, additional, Noreña, Ivan, additional, Reinkemeyer, Christina, additional, Giang, Le Thi Thu, additional, Fabiánová, Eleonóra, additional, Strhársky, Jozef, additional, Dell’Omo, Marco, additional, Murgia, Nicola, additional, Carrasco-Ribelles, Lucía A., additional, Violán, Concepción, additional, Mates, Dana, additional, Rascu, Agripina, additional, Vimercati, Luigi, additional, De Maria, Luigi, additional, Asafo, Shuffield S., additional, Ditano, Giorgia, additional, Abedini, Mahsa, additional, and Boffetta, Paolo, additional

Published
2023
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42. Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Author

Gentilotti, Elisa, primary, Górska, Anna, additional, Tami, Adriana, additional, Gusinow, Roy, additional, Mirandola, Massimo, additional, Rodríguez Baño, Jesús, additional, Palacios Baena, Zaira R., additional, Rossi, Elisa, additional, Hasenauer, Jan, additional, Lopes-Rafegas, Iris, additional, Righi, Elda, additional, Caroccia, Natascia, additional, Cataudella, Salvatore, additional, Pasquini, Zeno, additional, Osmo, Thomas, additional, Del Piccolo, Lidia, additional, Savoldi, Alessia, additional, Kumar-Singh, Samir, additional, Mazzaferri, Fulvia, additional, Caponcello, Maria Giulia, additional, de Boer, Gerolf, additional, Hara, Gabriel Levy, additional, De Nardo, Pasquale, additional, Malhotra, Surbhi, additional, Canziani, Lorenzo Maria, additional, Ghosn, Jade, additional, Florence, Aline-Marie, additional, Lafhej, Nadhem, additional, van der Gun, Bernardina T.F., additional, Giannella, Maddalena, additional, Laouénan, Cédric, additional, Tacconelli, Evelina, additional, Pinho Guedes, Mariana Nunes, additional, Maccarrone, Gaia, additional, Pezzani, Maria Diletta, additional, Sibani, Marcella, additional, Davies, Ruth Joanna, additional, Vitali, Stefania, additional, Franchina, Giorgia, additional, Tomassini, Giorgia, additional, Sciammarella, Concetta, additional, Cecchetto, Riccardo, additional, Gibellini, Davide, additional, De Toffoli, Chiara Konishi, additional, Rosini, Giulia, additional, Perlini, Chiara, additional, Meroi, Marco, additional, Puviani, Filippo Cioli, additional, Fasan, Daniele, additional, Micheletto, Claudio, additional, Montemezzi, Stefania, additional, Cardobi, Nicolò, additional, Vantini, Gianluca, additional, Mazzali, Gloria, additional, Stabile, Giovanni, additional, Marcanti, Maddalena, additional, Zonta, Marco Pattaro, additional, Calì, Deborah, additional, Mason, Anna, additional, Perlini, Cinzia, additional, Gisondi, Paolo, additional, Mongardi, Maria, additional, Sorbello, Simona, additional, Wold, Karin I., additional, Vincenti-González, María F., additional, Veloo, Alida C.M., additional, Harmsma, Valerie P.R., additional, Pantano, Daniele, additional, van der Meer, Margriet, additional, Gard, Lilli, additional, Lizarazo, Erley F., additional, Knoester, Marjolein, additional, Friedrich, Alex W., additional, Niesters, Hubert G.M., additional, Viale, Pierluigi, additional, Marzolla, Domenico, additional, Cosentino, Federica, additional, Di Chiara, Michela, additional, Fornaro, Giacomo, additional, Bonazzetti, Cecilia, additional, Tazza, Beatrice, additional, Toschi, Alice, additional, Vetamanu, Oana, additional, Giacomini, Maria Eugenia, additional, Trapani, Fabio, additional, Marconi, Lorenzo, additional, Attard, Luciano, additional, Tedeschi, Sara, additional, Gabrielli, Liliana, additional, Lazzarotto, Tiziana, additional, Olivares, Paula, additional, Castilla, Javier, additional, Vélez, Javier, additional, Almadana, Virginia, additional, Martín-Barrera, Lucía, additional, Martín-Gutiérrez, Ana Belén, additional, Gutiérrez-Campos, David, additional, Fernández-Regaña, Marta, additional, Silva-Campos, Ana, additional, Fernández-Riejos, Patricia, additional, García-Sánchez, M. Isabel, additional, Giuliano, Carla V., additional, López, Carlota, additional, Neumann, Gabriela, additional, Camporro, Julieta, additional, de Vedia, Lautaro, additional, Agugliaro, Hugo, additional, Scipione, Gabriella, additional, Dellacasa, Chiara, additional, Chandramouli, Balasubramanian, additional, Gioiosa, Silvia, additional, Naranjo, Juan Mata, additional, Ortali, Maurizio, additional, Konnova, Angelina, additional, Gupta, Akshita, additional, Smet, Mathias, additional, Hotterbeekx, An, additional, Berkell, Matilda, additional, Sicuri, Elisa, additional, Bachelet, Delphine, additional, Bouadma, Lila, additional, Cervantes-Gonzalez, Minerva, additional, Chair, Anissa, additional, Charpentier, Charlotte, additional, Chenard, Léo, additional, Descamps, Diane, additional, Doan, Hang, additional, Duval, Xavier, additional, Esposito-Farese, Marina, additional, Hoffmann, Isabelle, additional, Kafif, Ouifiya, additional, Le Hingrat, Quentin, additional, Letrou, Sophie, additional, Mentré, France, additional, Schneider, Marion, additional, Tardivon, Coralie, additional, Timsit, Jean-Francois, additional, Tubiana, Sarah, additional, Abrous, Amal, additional, Couffin-Cadiergues, Sandrine, additional, Da Silva, Fernanda Dias, additional, Esperou, Hélène, additional, Houas, Ikram, additional, Jaafoura, Salma, additional, Papadopoulos, Aurélie, additional, Ansart, Severine, additional, Auvet, Adrien, additional, Bani-Sadr, Firouzé, additional, Bernard, L., additional, Bissuel, François, additional, Botelho-Nevers, Elisabeth, additional, Bouhour, Damien, additional, Cabié, André, additional, Caraux Paz, Pauline, additional, Chidiac, Christian, additional, Chirouze, Catherine, additional, Chroboczek, Tomasz, additional, Cordel, Hugues, additional, Courtois, Roxane, additional, De Castro, Nathalie, additional, Diamamntis, Sylvain, additional, Diehl, Jean-Luc, additional, Djossou, Felix, additional, Dorival, Céline, additional, Epaulard, Olivier, additional, Gaborieau, Valerie, additional, Goehringer, François, additional, Gousseff, Marie, additional, Jamard, Simon, additional, Joseph, Cedric, additional, Lacombe, Karine, additional, Le Mestre, Soizic, additional, Le Moing, Vincent, additional, Lelievre, Jean-Daniel, additional, Lesens, Olivier, additional, Machado, M., additional, Maillet, Mylène, additional, Manda, Victoria, additional, Martin-Blondel, Guillaume, additional, Martinot, Martin, additional, Meysonnier, Vanina, additional, Molina, Jean-Michel, additional, Oziol, Eric, additional, Pestre, Vincent, additional, Piroth, Lionel, additional, Poissy, Julien, additional, Rabaud, Christian, additional, Raffi, François, additional, Rammaert, Blandine, additional, Rapp, Christophe, additional, Rebaudet, Stanislas, additional, Roger, Pierre-Marie, additional, Roux, Damien, additional, Senneville, Eric, additional, Tattevin, Pierre, additional, Wiedemann, Aurélie, additional, and Zucman, David, additional

Published
2023
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45. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy

Author

Rawlinson, William D, Boppana, Suresh B, Fowler, Karen B, Kimberlin, David W, Lazzarotto, Tiziana, Alain, Sophie, Daly, Kate, Doutré, Sara, Gibson, Laura, Giles, Michelle L, Greenlee, Janelle, Hamilton, Stuart T, Harrison, Gail J, Hui, Lisa, Jones, Cheryl A, Palasanthiran, Pamela, Schleiss, Mark R, Shand, Antonia W, and van Zuylen, Wendy J

Published
2017
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47. The Auditory Pathway in Congenitally Cytomegalovirus-Infected Human Fetuses.

Author

Gabrielli, Liliana, Bonasoni, Maria Paola, Piccirilli, Giulia, Petrisli, Evangelia, Venturoli, Simona, Cantiani, Alessia, Pavoni, Matteo, Marsico, Concetta, Capretti, Maria Grazia, Simonazzi, Giuliana, and Lazzarotto, Tiziana

Subjects
AUDITORY pathways, INNER ear, AUDITORY cortex, TEMPORAL lobe, BRAIN damage, SENSORINEURAL hearing loss
Abstract

Congenital cytomegalovirus (CMV) infection is the main cause of non-hereditary sensorineural hearing loss (SNHL). In order to shed light on SNHL pathophysiology, we examined the auditory pathway in CMV-infected fetuses; the temporal lobe, in particular the auditory cortex, and the inner ear. We investigated both inner ears and temporal lobes of 20 human CMV-infected fetuses at 21 weeks of gestation. As a negative group, five fetuses from spontaneous miscarriages without CMV infection were studied. Inner ears and temporal lobes were histologically examined, immunohistochemistry for CMV and CMV-PCR were performed. On the auditory cortex, we evaluated the local microglial reaction to the infection. CMV-positive cells were found in 14/20 brains and the damage was classified as severe, moderate, or mild, according to histological features. Fetuses with severe brain damage had a statistically higher temporal lobe viral load and a higher number of activated microglial cells in the auditory cortex compared to fetuses with mild brain damage (p: 0.01; p: 0.01). In the inner ears, the marginal cells of the stria vascularis were the most CMV positive. In our study, CMV affected the auditory pathway, suggesting a tropism for this route. In addition, in the auditory cortex, microglial activation may favor further tissue damage contributing to hearing loss. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Toxoplasmosis in Transplant Recipients, Europe, 2010-2014

Author

Robert-Gangneux, Florence, Meroni, Valeria, Dupont, Damien, Botterel, Frangoise, Garcia, Jose M. Aguado, Brenier- Pinchart, Marie-Pierre, Accoceberry, Isabelle, Akan, Hamdi, Abbate, Isabella, Boggian, Katia, Bruschi, Fabrizio, Carratala, Jordi, David, Miruna, Drgona, Lubos, Djurkovic-Djakovic, Olgica, Farinas, Maria Carmen, Genco, Francesca, Gkrania-Klotsas, Effrossyni, Groll, Andreas H., Guy, Edward, Hirzel, Cedric, Khanna, Nina, Kurt, Ozgur, Junie, Lia Monica, Lazzarotto, Tiziana, Len, Oscar, Mueller, Nicolas J., Munoz, Patricia, Pana, Zoi Dorothea, Roilides, Emmanuel, Stajner, Tijana, van Delden, Christian, Villena, Isabelle, Pelloux, Herve, and Manuel, Oriol

Subjects
Toxoplasmosis -- Health aspects, Hematopoietic stem cell transplantation -- Health aspects, Stem cells -- Health aspects, Organ transplantation -- Health aspects, Liver -- Health aspects, Health
Abstract

Toxoplasmosis is a zoonosis that infects humans and other warm-blooded animals worldwide; prevalence and clinical severity vary by geographic area (1). After primary infection, the parasite persists lifelong within dormant [...]

Published
2018
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49. Dual combined antiviral treatment with remdesivir and nirmatrelvir/ritonavir in patients with impaired humoral immunity and persistent SARS‐CoV‐2 infection

Author

Pasquini, Zeno, primary, Toschi, Alice, additional, Casadei, Beatrice, additional, Pellegrini, Cinzia, additional, D’Abramo, Alessandra, additional, Vita, Serena, additional, Beccacece, Alessia, additional, Bussini, Linda, additional, Chionsini, Maria Clara, additional, Dentale, Nicola, additional, Cantiani, Alessia, additional, Lazzarotto, Tiziana, additional, Bartoletti, Michele, additional, Nicastri, Emanuele, additional, Zinzani, Pierluigi, additional, Giannella, Maddalena, additional, and Viale, Pierluigi, additional

Published
2023
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