1. 'RaMassays': Synergistic Enhancement of Plasmon-Free Raman Scattering and Mass Spectrometry for Multimodal Analysis of Small Molecules
- Author
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Nicolò Bontempi, Michela Bertuzzi, Maurizio Memo, Ivano Alessandri, Irene Vassalini, and Alessandra Gianoncelli
- Subjects
Materials science ,Nanoparticle ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,Mass spectrometry ,01 natural sciences ,SERS SENSITIVITY ,Article ,NANOANTENNAS ,symbols.namesake ,LASER-DESORPTION-IONIZATION ,Ionization ,NANOPARTICLES ,Spectroscopy ,MALDI ,Plasmon ,Plasmonic nanoparticles ,ENVIRONMENT ,Multidisciplinary ,SPECTROSCOPY ,TIO2 ,PEPTIDES ,DISCOVERY ,021001 nanoscience & nanotechnology ,Small molecule ,0104 chemical sciences ,symbols ,0210 nano-technology ,Raman scattering - Abstract
SiO2/TiO2 core/shell (T-rex) beads were exploited as “all-in-one” building-block materials to create analytical assays that combine plasmon-free surface enhanced Raman scattering (SERS) and surface assisted laser desorption/ionization (SALDI) mass spectrometry (RaMassays). Such a multi-modal approach relies on the unique optical properties of T-rex beads, which are able to harvest and manage light in both UV and Vis range, making ionization and Raman scattering more efficient. RaMassays were successfully applied to the detection of small (molecular weight, M.W.
- Published
- 2016