794 results on '"LADENSTEIN, Ruth"'
Search Results
2. Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation
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Kirchberger, Stefanie, Shoeb, Mohamed R., Lazic, Daria, Wenninger-Weinzierl, Andrea, Fischer, Kristin, Shaw, Lisa E., Nogueira, Filomena, Rifatbegovic, Fikret, Bozsaky, Eva, Ladenstein, Ruth, Bodenmiller, Bernd, Lion, Thomas, Traver, David, Farlik, Matthias, Schöfer, Christian, Taschner-Mandl, Sabine, Halbritter, Florian, and Distel, Martin
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- 2024
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3. Barriers and facilitators to implementation of the interoperable Survivorship Passport (SurPass) v2.0 in 6 European countries: a PanCareSurPass online survey study
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van den Oever, Selina R., de Beijer, Ismay A. E., Kremer, Leontien C. M., Alfes, Marie, Balaguer, Julia, Bardi, Edit, Nieto, Adela Cañete, Cangioli, Giorgio, Charalambous, Eliana, Chronaki, Catherine, Costa, Tiago, Degelsegger, Alexander, Düster, Vanessa, Filbert, Anna-Liesa, Grabow, Desiree, Gredinger, Gerald, Gsell, Hannah, Haupt, Riccardo, van Helvoirt, Maria, Ladenstein, Ruth, Langer, Thorsten, Laschkolnig, Anja, Muraca, Monica, Rascon, Jelena, Schreier, Günter, Tomasikova, Zuzana, Tormo, Maria Teresa, Trinkunas, Justas, Trollip, Jessica, Trunner, Kathrin, Uyttebroeck, Anne, van der Pal, Helena J. H., and Pluijm, Saskia M. F.
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- 2024
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4. Solid Tumours
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Ladenstein, Ruth, Pedrazzoli, Paolo, Rosti, Giovanni, Sureda, Anna, editor, Corbacioglu, Selim, editor, Greco, Raffaella, editor, Kröger, Nicolaus, editor, and Carreras, Enric, editor
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- 2024
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5. Do national cancer control plans address care and research for children, adolescents, and young adults? A review of status, priorities, and recommendations across 41 European countries
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Prades, Joan, Kozhaeva, Olga, Otth, Maria, Kearns, Pamela, Ladenstein, Ruth, Rizzari, Carmelo, Heenen, Delphine, Dirksen, Uta, Owens, Cormac, Lazarov, Deyan, Sheehan, Ciara, Borras, Josep M., and Vassal, Gilles
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- 2025
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6. International benchmarking of stage at diagnosis for six childhood solid tumours (the BENCHISTA project): a population-based, retrospective cohort study
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Aitken, Joanne, O'Neill, Leisa, Youlden, Danny, Hackl, Monika, Ladenstein, Ruth, Van Eycken, Elizabeth, Van Damme, Nancy, Frazier, Lindsay, De Camargo, Beatriz, de Oliveira Santos, Marceli, Lima, Carlos A., Ramos, Walmiro, Cabral Formigosa, Lucrecia Aline, Ferreira dos Santos, Luciana, Casale, Claudina Agnese, Patrus Pena, Gil, Natívio, Juliana, Asturian Laporte, Cyntia, Santos de Menezes Miranda, Cristiana, Bastos Daniel, Cristiane, Nonata de Paulo, Raimunda, Veneziano, Donaldo B., Pontes de Aquino, Angela, Fernandes de Souza, Paulo Cesar, Valentim Leite, Rebeca, Valerianova, Zdravka, Konstantinov, Dobrin, Gupta, Sumit, Pole, Jason D., Sekerija, Mario, Stary, Jan, Sterba, Jaroslav, Hjalgrim, Lisa L., Falck Winther, Jeanette, Paapsi, Keiu, Lacour, Brigitte, Desandes, Emmanuel, Clavel, Jacqueline, Poulalhon, Claire, Ressing, Meike, Truebenbach, Claudia, Spix, Claudia, Petridou, Eleni T., Bouka, Evdoxia, Jakab, Zsuzsanna, Garami, Miklos, Galasso, Rocco, Sampietro, Giuseppe, Vetrano, Francesco, Sessa, Marcella, Maule, Milena M., Sacerdote, Carlotta, Ballotari, Paola, De Santis, Emilia, Ferrante, Margherita, Ragusa, Rosalia, Mian, Michael, Boni, Luca, Rognoni, Magda, Amodio, Rosalba, Boschetti, Lorenza, Cuccaro, Francesco, Bruno, Danila, Russo, Antonio G., Gervasi, Federico, Gambino, Maria L., Borciani, Elisabetta, Michiara, Maria, Mangone, Lucia, Spagnoli, Gianbattista, Ferretti, Stefano, Falcini, Fabio, Spata, Eugenia, Manasse, Sonia, Coccia, Paola, Bella, Francesca, Caldarella, Adele, Intrieri, Teresa, Scuderi, Tiziana, Rizzello, Roberto V., Zorzi, Manuel, Guzzinati, Stefano, Murray, Deirdre, Matsuda, Tomohiro, Nakata, Kayo, Azzopardi, Miriam J., Børge Johannesen, Tom, Dahlen, Aina H., Zeller, Bernward, Kowalczyk, Jerzy, Raciborska, Anna, Ferreira, Ana M., Caldas, Gabriela, Bucurenci, Mihaela, Coza, Dana, Zadnik, Vesna, Lopez de Munain, Arantza, Almela-Vich, Fernando, Jeghalef-El Karoui, Noura, Marcos-Gragera, Rafael, José Sanchez, Maria, Aragonés, Nuria, Parra-Blázquez, David, Chirlaque, Maria Dolores, Guevara, Marcela, Pardo, Elena, Peris-Bonet, Rafael, Cañete Nieto, Adela, Carulla, Marià, Lähteenmäki, Päivi, Kuehni, Claudia E., Redmond, Shelagh M., Visser, Otto, Karim-Kos, Henrike, Stevens, Sarah, Irvine, Lucy, Stiller, Charles, Gavin, Anna, Fitzpatrick, Deirdre, Bennet, Damien, Morrison, David S., Smith, Karen, Huws, Dyfed Wyn, Smits, Stephanie, Gaspar, Nathalie, Spreafico, Filippo, Bailey, Simon, Klein, Méric, Di Cataldo, Andrea, Capocaccia, Riccardo, Polanco, Angela, Green, Giles, Botta, Laura, Didonè, Fabio, Lopez-Cortes, Angela, Nieto, Adela Cañete, Hjalgrim, Lisa L, Stiller, Charles A, Gatta, Gemma, and Pritchard-Jones, Kathy
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- 2025
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7. Differences in care delivery for children and adolescents with cancer in Europe – Results from the SIOPE OCEAN project
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Otth, Maria, de Rojas, Teresa, Rauwolf, Kerstin K., Martins, Miguel, Dirksen, Uta, Heenen, Delphine, Kameric, Lejla, Kearns, Pamela, Ladenstein, Ruth, Owens, Cormac, Queiroz, Caroline, Sullivan, Richard, Rizzari, Carmelo, and Vassal, Gilles
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- 2025
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8. Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trial
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Koscielniak, Ewa, Ljungman, Gustaf, Kazanowska, Bernarda, Niggli, Felix, Sparber-Sauer, Monika, Handgretinger, Rupert, Zimmermann, Martin, Boos, Joachim, Blank, Bernd, Hallmen, Erika, Teichert von Lüttichau, Irene, Schmid, Irene, Fröhlich, Birgit, Müller, Hermann L., Behnisch, Wolfgang, Ladenstein, Ruth, Scheer, Monika, Vokuhl, Christian, von Kalle, Thekla, Blattmann, Claudia, Bielack, Stefan, and Klingebiel, Thomas
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- 2024
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9. Common core variables for childhood cancer data integration
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Di Carlo, Daniela, Ladenstein, Ruth, Graf, Norbert, Merks, Johannes Hans, Hernández-Peñaloza, Gustavo, Kearns, Pamela, and Bisogno, Gianni
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- 2024
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10. Retrospective comparative analysis of two medical evacuation systems for Ukrainian patients affected by war
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Adyrov, Mykhaylo V, Alanbousi, Inna, Alexander, Sarah Weeks, Apel, Anna, Avula, Meghana, Bal, Wioletta Anna, Balwierz, Walentyna Aniela, Basset-Salom, Luisa, Bastardo Blanco, Daniel, Bauer, Karolina Jadwiga, Bayazitov, Ildar T, Berlanga, Pablo, Bhakta, Nickhill Hitesh, Bieniek, Katarzyna Anna, Bien, Ewa Iwona, Blackwood, Christopher Andrew, Blair, Sally Jane, Bodak, Khrystyna Ihorivna, Bordeianu, Irina, Bouffet, Eric Eric, Braganca, Joao Maria, Bucurenci, Mihaela Silvia, Budny, Elżbieta Beata, Budzyn, Andrii, Bumgardner, Christopher Carl, Burditt, Raina Nichole, Burnside Clapp, Victoria, Bykov, Viacheslav Valeriyovych, Cañete, Adela, Carnelli, Monica, Cela, Elena, Cepowska, Zuzanna, Chaber, Radoslaw, Cherner-Drieux, Anna, Chubata, Mariya, Clough, Heidi M, Czauderna, Piotr Stefan, Czernicka - Siwecka, Jolanta, Czyzewski, Krzysztof, Dalle, Jean-Hugues, Dashchakovska, Olha, de Koning, Linda A, Dembowska-Baginska, Bozenna Malgorzata, Derwich, Katarzyna, Dirksen, Uta, Dommett, Rachel, Dorosh, Olha Ihorivna, dos Reis Farinha, Nuno Jorge, Drabko, Katarzyna Anna, Dragomir, Monica Desiree, Dutkiewicz, Malgorzata, Dworzak, Michael, Dyma, Sergii Vitaliiovych, Earl, Julian, Eggert, Angelika, English, Martin William, Farren, Becky S, Fedyk, Nataliia Yuriina, Fernández-Teijeiro, Ana, Ferneza, Severyn Romanovych, Foster, Whitney Baer, Fox Irwin, Leeanna Elizabeth, Gałązkowski, Robert Maciej, Ganieva, Galyna, Garanzha, Vasylyna Andriivna, Gelman, Marina S, Godzinski, Jan Krzysztof, Goeres, Anne Françoise, Golban, Rodica, Graetz, Dylan Elizabeth, Greiner, Jeanette, Griksaitis, Michael J, Gupta, Sumit, Hampel, Michal Andrzej, Hastings, Sara Grace, Heenen, Delphine Liliane, Hill, Marcela C, Holiuk, Ihor, Holter, Wolfgang, Hough, Rachael Emma, Hutnik, Lukasz Marek, Irga-Jaworska, Ninela, Istomin, Oleksandr Andriyovych, Ignatova, Anna, Janczar, Szymon Lech, Kacharian, Arman, Kalwak, Krzysztof, Karolczyk, Grażyna Małgorzata, Karpenko, Nataliia Mikolaivna, Katsubo, Halyna Oleksandrivna, Kattamis, Antonis, Kazanowska, Bernarda Jadwiga, Kentsis, Alex, Ketteler, Petra, Kienesberger, Anita, Kiselev, Roman, Kizyma, Zoryana Petrivna, Kliuchkivska, Khrystyna, Klymniuk, Hryhorii Ivanovych, Kolenova, Alexandra, Kolodrubiec, Julia, Kostiuk, Yuliia, Kowalik, Tomasz, Kozlova, Olena Igorivna, Kozubenko, Vladyslav, Kraal, Kathelijne, Kramar, Tetyana Oleksandrivna, Krawczuk-Rybak, Maryna Maryna, Kulemzina, Irina, Kurkowska, Paulina, Kuzyk, Andriy S., Ladenstein, Ruth Lydia, Laguna, Pawel Jozef, Lassaletta, Alvaro, Lehmberg, Kai, Leontieva, Oksana, Liashenko, Serhii, Loizou, Loizos G., Lucchetta, Sonia Anna, Lupo, Matthew William, Lysytsia, Lesya, Lysytsia, Oleksandr, Machnik, Katarzyna Anna, Massimino, Maura, Mainland, Jeff A, Matczak, Katarzyna, Matysiak, Michal Jacek, Mayeur, Pierre, Miller, Beth Anne, Minervina, Anastasia A, Mishkova, Volha, Mizia-Malarz, Agnieszka Joanna, Morales La Madrid, Andres, Moreira, Daniel C, Moreno, Lucas, Moskvin, Vadim P, Mukkada, Sheena Teresa, Muszyńska-Rosłan, Katarzyna Maria, Mykychak, Iryna Volodymyrivna, Niemeyer, Charlotte, Nelson, Akoya Janae', Nogovitsyna, Yuliya, Ociepa, Tomasz, Oltolini, Stefano, Onipko, Nataliia, Pappas, Andrew, Patel, Amit B, Patrahau, Alina Alina, Pauley, Jennifer L., Pavlenko, Yehor Mikhailovich, Pavlovych, Andrij Oleksandrovych, Peregud-Pogorzelski, Jarosław Władyslaw, Perek-Polnik, Marta, Pérez, Vanesa, Pérez-Martínez, Antonio, Pikman, Yana, Pitozzi, Graziano Pitozzi, Portugal, Rui Gentil, Posternak, Victoria Vita, Pleshkan, Viktoriya, Prete, Arcangelo, Pritchard-Jones, Kathy, Raciborska, Anna, Radaelli, Alessandra, Reeves, Tegan Jemma, Reinhardt, Dirk, Reshetnyak, Andrey V, Rider, Andrew Jacob, Rizzari, Carmelo, Rizzi, Damiano Damiano, Rodriguez Hermosillo, Karen Gabriela, Ronenko, Olena Volodymyrivna, Rostkowska, Aneta Olga, Rudko, Liudmyla Yaroslavivna, Sakaan, Firas Mohamed, Sakhar, Nadezhda Aleksandrovna, Salman, Zeena S, Savva, Natallia N., Scaccaglia, Davide, Schaeffer, Elizabeth Hawthorne, Schneider, Carina Ursula, Scobie, Nicole, Semeniuk, Olena Volodymyrivna, Shevchyk, Roksoliana, Shuler, Ana I., Shvets, Stanislav, Sniderman, Liz, Skoczen, Szymon Pawel, Smeal, William John, Sokolowski, Igor, Sonkin, Anna Alexandra, Spolinyak, Andriy, Spota, Andrea, Sramkova, Lucie, Stepanjuk, Alla Ivanivna, Sterba, Jaroslav, Strahm, Brigitte, Styczynski, Jan, Svintsova, Olha, Synyuta, Andriy V, Szczepanski, Tomasz, Szczucinski, Pawel Kukiz, Szmyd, Bartosz Miroslaw, Tasso Cereceda, Maria, Teliuk, Alina, Tomanek, Iwona, Topping, Phoebe, Torrent, Montserrat, Trelińska, Joanna, Troyanovska, Olha Orestivna, Tsurkan, Lyudmila G., Tsymbalyuk-Voloshyn, Iryna, Tyupa, Sergiy Ihorovych, Urasinski, Tomasz Franciszek, Urbanek Dądela, Agnieszka, Vasilieva, Nataliia Jroslavivna, Vasilyeva, Aksana, Verdú-Amorós, Jaime, Vilcu-Bajurean, Natalia, Vinitsky, Leo, Vivtcharenko, Victoria, Vovk, Nelia, Volpe, Giovanni, Vorobel, Oksana Ivanivna, Wachowiak, Jacek Tadeusz, Wasiak, Marcin Slawomir, Wiedower, Lance Allan, Wobst, Natalia, Wuenschel, Lena Isolde, Wysocki, Mariusz Stanislaw, Yurieva, Marina, Zagurska, Anastasiia, Zakharenko, Stanislav S, Zakharenko, Aelita V, Zapotochna, Khrystyna, Zawitkowska, Joanna Emilia, Zecca, Marco, Mueller, Alexandra, Salek, Marta, Oszer, Aleksandra, Evseev, Dmitry, Yakimkova, Taisiya, Wlodarski, Marcin, Vinitsky, Anna, Kizyma, Roman, Pogorelyy, Mikhail, Zuber, Maria, Escalante, Juan, Lipska, Elzbieta, Fendler, Wojciech, Nowicka, Zuzanna, Szyszka, Adam, Rodriguez-Galindo, Carlos, Wise, Paul H., Agulnik, Asya, and Mlynarski, Wojciech
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- 2024
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11. Barriers and facilitators to the implementation of a new European eHealth solution (SurPass v2.0): the PanCareSurPass Open Space study
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de Beijer, Ismay A. E., Hardijzer, Emma C., Haupt, Riccardo, Grabow, Desiree, Balaguer, Julia, Bardi, Edit, Cañete Nieto, Adela, Ciesiūniene, Audronė, Düster, Vanessa, Filbert, Anna-Liesa, Gsell, Hannah, Kapitančukė, Monika, Ladenstein, Ruth, Langer, Thorsten, Muraca, Monica, van den Oever, Selina R., Prikken, Sofie, Rascon, Jelena, Tormo, Maria Teresa, Uyttebroeck, Anne, Vercruysse, Gertrui, van der Pal, Helena J. H., Kremer, Leontien C. M., and Pluijm, Saskia M. F.
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- 2023
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12. Long-term, continuous infusion of single-agent dinutuximab beta for relapsed/refractory neuroblastoma: an open-label, single-arm, Phase 2 study
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Lode, Holger N., Ehlert, Karoline, Huber, Stephanie, Troschke-Meurer, Sascha, Siebert, Nikolai, Zumpe, Maxi, Loibner, Hans, and Ladenstein, Ruth
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- 2023
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13. Irinotecan and temozolomide in combination with dasatinib and rapamycin versus irinotecan and temozolomide for patients with relapsed or refractory neuroblastoma (RIST-rNB-2011): a multicentre, open-label, randomised, controlled, phase 2 trial
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Corbacioglu, Selim, Lode, Holger, Ellinger, Susanne, Zeman, Florian, Suttorp, Meinolf, Escherich, Gabriele, Bochennek, Konrad, Gruhn, Bernd, Lang, Peter, Rohde, Marius, Debatin, Klaus Michael, Steinbach, Daniel, Beilken, Andreas, Ladenstein, Ruth, Spachtholz, Rainer, Heiss, Peter, Hellwig, Dirk, Tröger, Anja, Koller, Michael, Menhart, Karin, Riemenschneider, Markus J, Zoubaa, Saida, Kietz, Silke, Jakob, Marcus, Sommer, Gunhild, Heise, Tilman, Hundsdörfer, Patrick, Kühnle, Ingrid, Dilloo, Dagmar, Schönberger, Stefan, Schwabe, Georg, von Luettichau, Irene, Graf, Norbert, Schlegel, Paul-Gerhardt, Frühwald, Michael, Jorch, Norbert, Paulussen, Michael, Schneider, Dominik T, Metzler, Markus, Leipold, Alfred, Nathrath, Michaela, Imschweiler, Thomas, Christiansen, Holger, Schmid, Irene, Crazzolara, Roman, Niktoreh, Naghmeh, Cario, Gunnar, Faber, Joerg, Demmert, Martin, Babor, Florian, Fröhlich, Birgit, Bielack, Stefan, Bernig, Toralf, Greil, Johann, Eggert, Angelika, Simon, Thorsten, and Foell, Juergen
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- 2024
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14. Twinning to reduce research and innovation inequalities in paediatric solid tumours across Europe
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Rascon, Jelena, Blackute, Renata, Cerkauskiene, Alma, Taschner-Mandl, Sabine, Andrade, Nuno, Planinic, Adriana, Rutkowski, Stefan, Schuller, Ulrich, Nysom, Karsten, Tuckuviene, Ruta, Brok, Jesper, Schmiegelow, Kjeld, van den Heuvel-Eibrink, Marry M., van der Perk, M.E. Madeleine, Haupt, Riccardo, Muraca, Monica, Saraceno, Davide, Geoerger, Birgit, Manuzi, Giorgia, and Ladenstein, Ruth
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- 2024
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15. Scaling up and implementing the digital Survivorship Passport tool in routine clinical care – The European multidisciplinary PanCareSurPass project
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Filbert, Anna-Liesa, Kremer, Leontien, Ladenstein, Ruth, Chronaki, Catherine, Degelsegger-Márquez, Alexander, van der Pal, Heleen, Bardi, Edit, Uyttebroeck, Anne, Langer, Thorsten, Muraca, Monica, Nieto, Adela Cañete, Rascon, Jelena, Bagnasco, Francesca, Beyer, Stefan, te Dorsthorst, Jeroen, Essiaf, Samira, Galan, Antonio Orduña, Kienesberger, Anita, O’Brien, Kylie, Palau, Marisa Correcher, Pluijm, Saskia M.F., di Profio, Sonia, Saraceno, Davide, Schneider, Carina, Schreier, Günter, Trinkūnas, Justas, Zamberlan, Igor, Grabow, Desiree, and Haupt, Riccardo
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- 2024
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16. Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma
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Scheer, Monika, Hallmen, Erika, Vokuhl, Christian, Fuchs, Jörg, Tunn, Per-Ulf, Münter, Marc, Timmermann, Beate, Bauer, Sebastian, Henssen, Anton George, Kazanowska, Bernarda, Niggli, Felix, Ladenstein, Ruth, Ljungman, Gustaf, Eggert, Angelika, Klingebiel, Thomas, and Koscielniak, Ewa
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- 2023
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17. Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis
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Fetahu, Irfete S., Esser-Skala, Wolfgang, Dnyansagar, Rohit, Sindelar, Samuel, Rifatbegovic, Fikret, Bileck, Andrea, Skos, Lukas, Bozsaky, Eva, Lazic, Daria, Shaw, Lisa, Tötzl, Marcus, Tarlungeanu, Dora, Bernkopf, Marie, Rados, Magdalena, Weninger, Wolfgang, Tomazou, Eleni M., Bock, Christoph, Gerner, Christopher, Ladenstein, Ruth, Farlik, Matthias, Fortelny, Nikolaus, and Taschner-Mandl, Sabine
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- 2023
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18. Radiotherapy quality assurance in paediatric clinical trials: first report from six QUARTET-affiliated trials
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Kelly, Sarah M, Turcas, Andrada, Corning, Coreen, Bailey, Simon, Cañete, Adela, Clementel, Enrico, di Cataldo, Andrea, Dieckmann, Karin, Gaze, Mark N, Horan, Gail, Jenney, Meriel, Ladenstein, Ruth, Padovani, Laetitia, Valteau-Couanet, Dominique, Boterberg, Tom, and Mandeville, Henry
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- 2023
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19. Correction: Barriers and facilitators to the implementation of a new European eHealth solution (SurPass v2.0): the PanCareSurPass Open Space study
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de Beijer, Ismay A. E., Hardijzer, Emma C., Haupt, Riccardo, Grabow, Desiree, Balaguer, Julia, Bardi, Edit, Nieto, Adela Cañete, Ciesiūniene, Audronė, Düster, Vanessa, Filbert, Anna-Liesa, Gsell, Hannah, Kapitančukė, Monika, Ladenstein, Ruth, Langer, Thorsten, Muraca, Monica, van den Oever, Selina R., Prikken, Sofie, Rascon, Jelena, Tormo, Maria Teresa, Uyttebroeck, Anne, Vercruysse, Gertrui, van der Pal, Helena J. H., Kremer, Leontien C. M., and Pluijm, Saskia M. F.
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- 2024
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20. High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008.
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Dirksen, Uta, Brennan, Bernadette, Le Deley, Marie-Cécile, Cozic, Nathalie, van den Berg, Henk, Bhadri, Vivek, Brichard, Bénédicte, Claude, Line, Craft, Alan, Amler, Susanne, Gaspar, Natalie, Gelderblom, Hans, Goldsby, Robert, Gorlick, Richard, Grier, Holcombe E, Guinbretiere, Jean-Marc, Hauser, Peter, Hjorth, Lars, Janeway, Katherine, Juergens, Heribert, Judson, Ian, Krailo, Mark, Kruseova, Jarmila, Kuehne, Thomas, Ladenstein, Ruth, Lervat, Cyril, Lessnick, Stephen L, Lewis, Ian, Linassier, Claude, Marec-Berard, Perrine, Marina, Neyssa, Morland, Bruce, Pacquement, Hélène, Paulussen, Michael, Randall, R Lor, Ranft, Andreas, Le Teuff, Gwénaël, Wheatley, Keith, Whelan, Jeremy, Womer, Richard, Oberlin, Odile, Hawkins, Douglas S, and Euro-E.W.I.N.G. 99 and Ewing 2008 Investigators
- Subjects
Euro-E.W.I.N.G. 99 and Ewing 2008 Investigators ,Humans ,Bone Neoplasms ,Lung Neoplasms ,Neoplasm Recurrence ,Local ,Disease Progression ,Antineoplastic Combined Chemotherapy Protocols ,Neoadjuvant Therapy ,Radiotherapy ,Adjuvant ,Pneumonectomy ,Hematopoietic Stem Cell Transplantation ,Transplantation ,Autologous ,Risk Assessment ,Risk Factors ,Time Factors ,Adolescent ,Adult ,Middle Aged ,Child ,Child ,Preschool ,Infant ,Europe ,Female ,Male ,Young Adult ,Sarcoma ,Ewing ,Progression-Free Survival ,Lung ,Stem Cell Research ,Cancer ,Pediatric ,Rare Diseases ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Clinical Sciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
PurposeThe R2Pulm trial was conducted to evaluate the effect of busulfan-melphalan high-dose chemotherapy with autologous stem-cell rescue (BuMel) without whole-lung irradiation (WLI) on event-free survival (main end point) and overall survival, compared with standard chemotherapy with WLI in Ewing sarcoma (ES) presenting with pulmonary and/or pleural metastases.MethodsFrom 2000 to 2015, we enrolled patients younger than 50 years of age with newly diagnosed ES and with only pulmonary or pleural metastases. Patients received chemotherapy with six courses of vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) and one course of vincristine, dactinomycin, and ifosfamide (VAI) before either BuMel or seven courses of VAI and WLI (VAI plus WLI) by randomized assignment. The analysis was conducted as intention to treat. The estimates of the hazard ratio (HR), 95% CI, and P value were corrected for the three previous interim analyses by the inverse normal method.ResultsOf 543 potentially eligible patients, 287 were randomly assigned to VAI plus WLI (n = 143) or BuMel (n = 144). Selected patients requiring radiotherapy to an axial primary site were excluded from randomization to avoid excess organ toxicity from interaction between radiotherapy and busulfan. Median follow-up was 8.1 years. We did not observe any significant difference in survival outcomes between treatment groups. Event-free survival was 50.6% versus 56.6% at 3 years and 43.1% versus 52.9% at 8 years, for VAI plus WLI and BuMel patients, respectively, resulting in an HR of 0.79 (95% CI, 0.56 to 1.10; P = .16). For overall survival, the HR was 1.00 (95% CI, 0.70 to 1.44; P = .99). Four patients died as a result of BuMel-related toxicity, and none died after VAI plus WLI. Significantly more patients in the BuMel arm experienced severe acute toxicities than in the VAI plus WLI arm.ConclusionIn ES with pulmonary or pleural metastases, there is no clear benefit from BuMel compared with conventional VAI plus WLI.
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- 2019
21. Risk stratification in neuroblastoma patients through machine learning in the multicenter PRIMAGE cohort.
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Lozano-Montoya, Jose, Jimenez-Pastor, Ana, Fuster-Matanzo, Almudena, Weiss, Glen J., Cerda-Alberich, Leonor, Veiga-Canuto, Diana, Martínez-de-Las-Heras, Blanca, Cañete-Nieto, Adela, Taschner-Mandl, Sabine, Hero, Barbara, Simon, Thorsten, Ladenstein, Ruth, Marti-Bonmati, Luis, and Alberich-Bayarri, Angel
- Abstract
Introduction: Neuroblastoma, the most prevalent solid cancer in children, presents significant biological and clinical heterogeneity. This inherent heterogeneity underscores the need for more precise prognostic markers at the time of diagnosis to enhance patient stratification, allowing for more personalized treatment strategies. In response, this investigation developed a machine learning model using clinical, molecular, and magnetic resonance (MR) radiomics features at diagnosis to predict patient's overall survival (OS) and improve their risk stratification. Methods: PRIMAGE database, including 513 patients (discovery cohort), was used for model training, validation, and testing. Additional 22 patients from different hospitals served as an external independent cohort. Primary tumor segmentation on T2-weighted MR images was semi-automatically edited by an experienced radiologist. From this area, 107 radiomics features were extracted. For the development of the prediction model, radiomics features were harmonized following the nested ComBat methodology and nested cross-validation approach was employed to determine the optimal preprocessing and model configuration. Results: The discovery cohort yielded a 78.8 ± 4.9 and 77.7 ± 6.1 of C index and time-dependent area under de curve (AUC), respectively, over the test set, with a random survival forest exhibiting the best performance. In the independent cohort, a C-index of 93.4 and a time-dependent AUC of 95.4 were achieved. Interpretability analysis identified lesion heterogeneity, size, and molecular variables as crucial factors in OS prediction. The model stratified neuroblastoma patients into low-, intermediate-, and high-risk categories, demonstrating a superior stratification compared to standard-of-care classification system in both cohorts. Discussion: Our results suggested that radiomics features improve current risk stratification systems in patients with neuroblastoma. [ABSTRACT FROM AUTHOR]
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- 2025
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22. Long-Term Outcomes and Quality of Life of High-Risk Neuroblastoma Patients Treated with a Multimodal Treatment Including Anti-GD2 Immunotherapy: A Retrospective Cohort Study.
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Flaadt, Tim, Rehm, Jonas, Simon, Thorsten, Hero, Barbara, Ladenstein, Ruth L., Lode, Holger N., Grabow, Desiree, Nolte, Sandra, Crazzolara, Roman, Greil, Johann, Ebinger, Martin, Abele, Michael, Holzer, Ursula, Döring, Michaela, Schulte, Johannes H., Bader, Peter, Schlegel, Paul-Gerhardt, Eyrich, Matthias, Lang, Peter, and Klingebiel, Thomas
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THERAPEUTIC use of monoclonal antibodies ,RISK assessment ,TUMORS in children ,RESEARCH funding ,IMMUNOTHERAPY ,QUESTIONNAIRES ,TREATMENT effectiveness ,RETROSPECTIVE studies ,LONGITUDINAL method ,QUALITY of life ,COMBINED modality therapy ,MEDICAL records ,ACQUISITION of data ,NEUROBLASTOMA ,DISEASE risk factors - Abstract
Simple Summary: High-risk neuroblastoma is a childhood cancer with poor survival rates despite intensive treatment. Adding anti-GD2 immunotherapy to standard therapies has improved survival, but little is known about the long-term effects (of the anti-GD2-therapy) on and quality of life of survivors. This study followed patients treated with a multimodal treatment including anti-GD2 therapy for over 20 years to assess their outcomes, side effects, and quality of life. While many survivors experienced long-term health issues, such as hearing loss, endocrine problems, and autoimmune diseases, their overall quality of life was often better than that of the general population. This research provides valuable insights into the long-term impact of anti-GD2 therapy, helping to guide future treatments and improve outcomes for children with high-risk neuroblastoma. In addition, the findings highlight the need for lifelong medical care to manage late effects and improve treatment strategies. Background: The incorporation of anti-GD2 antibodies such as ch14.18/SP2/0 into the multimodal treatment of high-risk neuroblastoma (HR-NB) patients has improved their outcomes. As studies assessing the long-term outcomes, long-term sequelae, and health-related quality of life (HRQoL) of this treatment are limited, this retrospective analysis aimed to explore these. Patients and Methods: Between 1991 and 2002, 65 children received a multimodal treatment, including ch14.18/SP2/0, for primary HR-NB. All received chemotherapy according to the NB90/NB97 trial, 51 received high-dose chemotherapy, and all received ch14.18/SP2/0 treatment. We analyzed the long-term sequelae and HRQoL (EORTC QLQ-C30), and evaluated overall and event-free survival (OS/EFS). Results: Twenty-five survivors were evaluated for HRQoL and long-term effects. All reported long-term sequelae, including ototoxicity in 16/25 (64%), cardiac toxicity in 6/25 (24%), and endocrine toxicity in 19/25 (76%) patients. Chronic diarrhea was reported in 20% of female patients. Seven patients developed autoimmune diseases. HRQoL scores were better across multiple scales than those of the matched German general population. Twenty-five-year OS and EFS were 50.8% (95% confidence interval: 31–55) and 43% (30.1–55.3), with 33 (50.8%) long-term survivors. Thirty-two patients died: 28 (43.1%) because of progression/relapse and 4 (6.2%) because of secondary neoplasms. Conclusions: Multimodal treatment, including ch14.18/SP2/0, can achieve long-term survival in HR-NB patients, with a substantial proportion of survivors reporting better HRQoL compared to the general population. All patients reported long-term side effects mostly attributable to chemotherapy and radiotherapy. The relatively high prevalence of autoimmune diseases and persistent diarrhea warrants additional longitudinal research on individuals treated with anti-GD2 antibodies. [ABSTRACT FROM AUTHOR]
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- 2025
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23. Primary Mediastinal Ewing's Sarcoma: Post Hoc Analysis from Two International Multicenter Prospective Randomized Trials.
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Stork, Theresa, Ranft, Andreas, Aigner, Clemens, Jurgens, Heribert, Ladenstein, Ruth L., Timmermann, Beate, Van den Berg, Henk, Dirksen, Uta, and Collaud, Stéphane
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MEDIASTINUM ,RESEARCH funding ,DATA analysis ,RARE diseases ,TREATMENT effectiveness ,DESCRIPTIVE statistics ,LONGITUDINAL method ,COMBINED modality therapy ,RESEARCH ,STATISTICS ,EWING'S sarcoma ,OVERALL survival - Abstract
Simple Summary: Ewing sarcomas are rare, aggressive tumors, occurring mostly in children and adolescents. They usually derive from the bone; however, extraskeletal Ewing sarcomas develop in the soft tissue. Ewing sarcoma of the mediastinum is extremely rare; there are only a few cases reported in the literature. The outcome is usually poor with about 30% 5-year survival. We retrieved data from two international, multicenter, prospective, clinical trials investigating the optimal treatment for patients with Ewing sarcoma. We then analyzed the patient and treatment characteristics to gain a better understanding of this rare tumor entity. This study is the first to describe the prevalence of mediastinal Ewing sarcoma in a homogeneously treated patient cohort. Objective: Ewing sarcoma (EWS) of the mediastinum is extremely rare, with only a few cases reported in the literature. We aimed to gain a better understanding of primary mediastinal EWS, describing patients treated within two international, multicenter, prospective, randomized EWS trials. Methods: Data from patients with primary mediastinal EWS were retrieved from the database of the EURO-E.W.I.N.G.99 (ClinicalTrials.gov identifier: NCT00020566) and EWING 2008 (ClinicalTrials.gov identifier: NCT00987636) trials. Patient and treatment characteristics were analyzed. Results: Out of 2969 patients with EWS, 9 (0.3%) had primary mediastinal EWS. The median age at diagnosis was 30.5 years (4 to 49). At the time of diagnosis, n = 3 (33%) patients had synchronous metastases. All patients underwent multiagent chemotherapy. Local therapy for non-metastatic patients was surgery (n = 2, 22%), surgery and radiotherapy (n = 2, 22%) or radiotherapy alone (n = 2, 22%). Surgery consisted of extended resections in most patients (n = 3, 33%). Five-year survival for the whole cohort was 64%. Apart from one patient who was lost to follow-up, all patients (n = 4) who had undergone surgery were alive at the end of follow-up. Conclusions: Primary mediastinal ES is extremely rare, with a prevalence of 0.3% among EWS. Five-year survival was favorable compared to primary mediastinal sarcoma of all histologies and in line with EWS of different origin. [ABSTRACT FROM AUTHOR]
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- 2025
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24. Early Impact of Severe Acute Respiratory Syndrome Coronavirus 2 on Pediatric Clinical Research: A Pan-European and Canadian Snapshot in Time
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Ladenstein, Ruth, Mikolasek, Andrea, Christiaens, Daphné, Degraeuwe, Eva, Walle, Johan Vande, Nuytinck, Lieve, Mok, Elise, Maguire, Jonathon L., Lacaze-Masmonteil, Thierry, Pokorna, Pavla, Skovby, Pernille, Rajasaar, Heli, Kallio, Jaana, Lepola, Pirkko, Gras-Le Guen, Christele, Gottrand, Frédéric, Kaguelidou, Florentia, Chevassus, Hugues, Pin, Isabelle, Rouger-Gaudichon, Jérémie, Patel, Maya, Neumann, Eva, Schwab, Matthias, Losifidis, Elias, Roilides, Emmanuel, Murray, Máiréad, La Neve, Federica, Rocchi, Francesca, Hjelle, Sigrun Margrethe, Halvorsen, Thomas, Migdał, Marek, Wiśniewski, Aleksander, Cabrita, Inês Zimbarra, Torrão, Rita Carilho, Martins, Tiago, Trasorras, Cristina Serén, Martinón-Torres, Federico, Rane, Anders, Naumburg, Estelle, Posfay-Barbe, Klara M., Diezi, Manuel, Paioni, Paolo, Mahler, Fenna, de Wildt, Saskia N., Van der Geest, Tesa, Wilding, Karen, Mantha, Olivier L., Flamein, Florence, Turner, Mark A., Fernandes, Ricardo M., and Hankard, Régis
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- 2021
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25. Factors Influencing Implementation of the Survivorship Passport: The IT Perspective
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Chronaki, Catherine, primary, Charalambous, Eliana, additional, Cangioli, Giorgio, additional, Schreier, Günter, additional, van den Oever, Selina, additional, van der Pal, Helena, additional, Kremer, Leontien, additional, Uyttebroeck, Anne, additional, Van den Bosch, Bart, additional, Trinkunas, Justas, additional, Rascon, Jelena, additional, Ladenstein, Ruth, additional, Düster, Vanessa, additional, Bardi, Edit, additional, Walz, Diana, additional, Filbert, Anna-Liesa, additional, Grabow, Desiree, additional, Langer, Thorsten, additional, Cañete Nieto, Adela, additional, Orduña Galán, Antonio J., additional, Correcher Palau, Marisa, additional, Cavalca, Giacomo, additional, and Haupt, Riccardo, additional
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- 2022
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26. Amplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma subgroup
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Martinez-Monleon, Angela, Kryh Öberg, Hanna, Gaarder, Jennie, Berbegall, Ana P., Javanmardi, Niloufar, Djos, Anna, Ussowicz, Marek, Taschner-Mandl, Sabine, Ambros, Inge M., Øra, Ingrid, Sandstedt, Bengt, Beiske, Klaus, Ladenstein, Ruth, Noguera, Rosa, Ambros, Peter F., Gordon Murkes, Lena, Ljungman, Gustaf, Kogner, Per, Fransson, Susanne, and Martinsson, Tommy
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- 2022
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27. The impact of local control in the treatment of children with advanced infantile and adult-type fibrosarcoma: Experience of the cooperative weichteilsarkom studiengruppe (CWS)
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Sparber-Sauer, Monika, Vokuhl, Christian, Seitz, Guido, Stegmaier, Sabine, Hallmen, Erika, von Kalle, Thekla, Scheer, Monika, Münter, Marc, Bielack, Stefan S., Ladenstein, Ruth, Niggli, Felix, Ljungman, Gustaf, Fuchs, Joerg, Klingebiel, Thomas, and Koscielniak, Ewa
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- 2020
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28. Reproducibility Analysis of Radiomic Features from T2-weighted MRI after Processing and Segmentation Alternations in Neuroblastoma Tumors
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Veiga-Canuto, Diana, primary, Fernández-Patón, Matías, additional, Cerdà Alberich, Leonor, additional, Jiménez Pastor, Ana, additional, Gomis Maya, Armando, additional, Carot Sierra, Jose Miguel, additional, Sangüesa Nebot, Cinta, additional, Martínez de las Heras, Blanca, additional, Pötschger, Ulrike, additional, Taschner-Mandl, Sabine, additional, Neri, Emanuele, additional, Cañete, Adela, additional, Ladenstein, Ruth, additional, Hero, Barbara, additional, Alberich-Bayarri, Ángel, additional, and Martí-Bonmatí, Luis, additional
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- 2024
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29. Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma : Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry
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Sparber-Sauer, Monika, Dietzschold, Maximilian, Schoenstein, Anton, Heinz, Amadeus, Vokuhl, Christian, Pajtler, Kristian W., Harrabi, Semi, Lin, Yi-Lan, von Kalle, Thekla, Hagen, Rudolf, Ladenstein, Ruth, Kazanowska, Bernarda, Ljungman, Gustaf, Klingebiel, Thomas, Ebinger, Martin, Koscielniak, Ewa, Muenter, Marc, Timmermann, Beate, Sparber-Sauer, Monika, Dietzschold, Maximilian, Schoenstein, Anton, Heinz, Amadeus, Vokuhl, Christian, Pajtler, Kristian W., Harrabi, Semi, Lin, Yi-Lan, von Kalle, Thekla, Hagen, Rudolf, Ladenstein, Ruth, Kazanowska, Bernarda, Ljungman, Gustaf, Klingebiel, Thomas, Ebinger, Martin, Koscielniak, Ewa, Muenter, Marc, and Timmermann, Beate
- Abstract
BackgroundParameningeal location of rhabdomyosarcoma (PM RMS) is known to be an unfavorable prognostic factor. Scarce data are available on radiotherapy (RT) concepts with regard to outcome.MethodsTreatment and outcome of 395 children with PM RMS registered within two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry (1995-2021) were evaluated.ResultsPatients were IRS group II (n = 15) and III (n = 380) and received systemic treatment according to the enrolled protocols: I2VA (n = 172), VAIA/CEVAIE (n = 223). Delayed resection was performed in 88/395 (22%) patients, and RT was additionally given in 79/88 (90%) resected patients. RT was the predominant local treatment in 355/395 (90%) patients: hyperfractionated accelerated photon (HART; n = 77), conventionally fractionated photon (n = 91) or proton beam (n = 126), brachytherapy (n = 4), heavy ions (n = 1), not available (n = 56). In the subgroup of RT as only local treatment (n = 278), no intracranial tumor extension and complete remission at end of treatment were significant positive prognostic factors. No significant difference on tumor outcome was seen between different radiotherapy concepts. Long-term toxicity with mostly endocrinological and visual deficiencies was reported in 161/279 (58%) surviving patients with a lower trend after proton beam RT (48%) when compared to HART or conventionally fractionated photon RT (71% and 72%, respectively). Ten-year event-free and overall survival in the overall group were 62% (+/- 5, 95% confidence interval [CI]) and 67% (+/- 5, 95% CI); in the RT-only group 67% (+/- 6, 95% CI) and 71% (+/- 6, 95% CI), respectively.ConclusionCWS data confirm the recent RT concept in PM RMS. Long-term sequelae as endocrinological and visual deficiencies need to be addressed.
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- 2024
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30. IT-Related Barriers and Facilitators to the Implementation of a New European eHealth Solution, the Digital Survivorship Passport (SurPass Version 2.0): Semistructured Digital Survey
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Zorg en O&O, Cancer, Child Health, de Beijer, Ismay A.E., van den Oever, Selina R., Charalambous, Eliana, Cangioli, Giorgio, Balaguer, Julia, Bardi, Edit, Alfes, Marie, Nieto, Adela Cañete, Correcher, Marisa, da Costa, Tiago Pinto, Degelsegger-Márquez, Alexander, Düster, Vanessa, Filbert, Anna Liesa, Grabow, Desiree, Gredinger, Gerald, Gsell, Hannah, Haupt, Riccardo, van Helvoirt, Maria, Ladenstein, Ruth, Langer, Thorsten, Laschkolnig, Anja, Muraca, Monica, Pluijm, Saskia, Rascon, Jelena, Schreier, Günter, Tomášikova, Zuzana, Trauner, Florian, Trinkūnas, Justas, Trunner, Kathrin, Uyttebroeck, Anne, Kremer, Leontien C.M., van der Pal, Helena J.H., Chronaki, Catherine, PanCareSurPass Consortium, Zorg en O&O, Cancer, Child Health, de Beijer, Ismay A.E., van den Oever, Selina R., Charalambous, Eliana, Cangioli, Giorgio, Balaguer, Julia, Bardi, Edit, Alfes, Marie, Nieto, Adela Cañete, Correcher, Marisa, da Costa, Tiago Pinto, Degelsegger-Márquez, Alexander, Düster, Vanessa, Filbert, Anna Liesa, Grabow, Desiree, Gredinger, Gerald, Gsell, Hannah, Haupt, Riccardo, van Helvoirt, Maria, Ladenstein, Ruth, Langer, Thorsten, Laschkolnig, Anja, Muraca, Monica, Pluijm, Saskia, Rascon, Jelena, Schreier, Günter, Tomášikova, Zuzana, Trauner, Florian, Trinkūnas, Justas, Trunner, Kathrin, Uyttebroeck, Anne, Kremer, Leontien C.M., van der Pal, Helena J.H., Chronaki, Catherine, and PanCareSurPass Consortium
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- 2024
31. Common core variables for childhood cancer data integration
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Onderzoek Beeld, Di Carlo, Daniela, Ladenstein, Ruth, Graf, Norbert, Merks, Johannes Hans, Hernández-Peñaloza, Gustavo, Kearns, Pamela, Bisogno, Gianni, Onderzoek Beeld, Di Carlo, Daniela, Ladenstein, Ruth, Graf, Norbert, Merks, Johannes Hans, Hernández-Peñaloza, Gustavo, Kearns, Pamela, and Bisogno, Gianni
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- 2024
32. Barriers and facilitators to implementation of the interoperable Survivorship Passport (SurPass) v2.0 in 6 European countries: a PanCareSurPass online survey study
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Zorg en O&O, Cancer, Child Health, van den Oever, Selina R., de Beijer, Ismay A.E., Kremer, Leontien C.M., Alfes, Marie, Balaguer, Julia, Bardi, Edit, Nieto, Adela Cañete, Cangioli, Giorgio, Charalambous, Eliana, Chronaki, Catherine, Costa, Tiago, Degelsegger, Alexander, Düster, Vanessa, Filbert, Anna Liesa, Grabow, Desiree, Gredinger, Gerald, Gsell, Hannah, Haupt, Riccardo, van Helvoirt, Maria, Ladenstein, Ruth, Langer, Thorsten, Laschkolnig, Anja, Muraca, Monica, Rascon, Jelena, Schreier, Günter, Tomasikova, Zuzana, Tormo, Maria Teresa, Trinkunas, Justas, Trollip, Jessica, Trunner, Kathrin, Uyttebroeck, Anne, van der Pal, Helena J.H., Pluijm, Saskia M.F., on behalf of the PanCareSurPass consortium, Zorg en O&O, Cancer, Child Health, van den Oever, Selina R., de Beijer, Ismay A.E., Kremer, Leontien C.M., Alfes, Marie, Balaguer, Julia, Bardi, Edit, Nieto, Adela Cañete, Cangioli, Giorgio, Charalambous, Eliana, Chronaki, Catherine, Costa, Tiago, Degelsegger, Alexander, Düster, Vanessa, Filbert, Anna Liesa, Grabow, Desiree, Gredinger, Gerald, Gsell, Hannah, Haupt, Riccardo, van Helvoirt, Maria, Ladenstein, Ruth, Langer, Thorsten, Laschkolnig, Anja, Muraca, Monica, Rascon, Jelena, Schreier, Günter, Tomasikova, Zuzana, Tormo, Maria Teresa, Trinkunas, Justas, Trollip, Jessica, Trunner, Kathrin, Uyttebroeck, Anne, van der Pal, Helena J.H., Pluijm, Saskia M.F., and on behalf of the PanCareSurPass consortium
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- 2024
33. Solid Tumours
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Ladenstein, Ruth, Glogova, Evgenia, Lanza, Francesco, Carreras, Enric, editor, Dufour, Carlo, editor, Mohty, Mohamad, editor, and Kröger, Nicolaus, editor
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- 2019
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34. Use Cases Requiring Privacy-Preserving Record Linkage in Paediatric Oncology.
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Hayn, Dieter, Kreiner, Karl, Sandner, Emanuel, Baumgartner, Martin, Jammerbund, Bernhard, Falgenhauer, Markus, Düster, Vanessa, Devi-Marulkar, Priyanka, Schleiermacher, Gudrun, Ladenstein, Ruth, and Schreier, Guenter
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CANCER treatment ,TUMORS in children ,DATABASE management ,PRIVACY ,MEDICAL record linkage ,CHILDREN'S hospitals ,MEDICAL ethics ,SPECIALTY hospitals - Abstract
Simple Summary: Large datasets concerning childhood cancers are rare. Therefore, it is important to fully exploit all available data, which are distributed over several resources, including biomaterials, images, clinical trials, and registries. With privacy-preserving record linkage (PPRL), datasets can be merged, without disclosing the patients' identities. Although PPRL is already implemented or described in various settings, use case descriptions are fragmented and incomplete. The present paper gives an overview of current and future use cases of PPRL in childhood cancer. We screened the literature, projects, and trial protocols, analysed a hypothetical patient journey, and discussed use cases with experts. All the identified use cases were structured along six key dimensions. We conclude that PPRL is a key concept in childhood cancer. Therefore, PPRL strategies should already be considered when starting research projects, to avoid distributed data silos, to maximise the knowledge derived from collected data, and, ultimately, to improve outcomes for children with cancer. Large datasets in paediatric oncology are inherently rare. Therefore, it is paramount to fully exploit all available data, which are distributed over several resources, including biomaterials, images, clinical trials, and registries. With privacy-preserving record linkage (PPRL), personalised or pseudonymised datasets can be merged, without disclosing the patients' identities. Although PPRL is implemented in various settings, use case descriptions are currently fragmented and incomplete. The present paper provides a comprehensive overview of current and future use cases for PPRL in paediatric oncology. We analysed the literature, projects, and trial protocols, identified use cases along a hypothetical patient journey, and discussed use cases with paediatric oncology experts. To structure PPRL use cases, we defined six key dimensions: distributed personalised records, pseudonymisation, distributed pseudonymised records, record linkage, linked data, and data analysis. Selected use cases were described (a) per dimension and (b) on a multi-dimensional level. While focusing on paediatric oncology, most aspects are also applicable to other (particularly rare) diseases. We conclude that PPRL is a key concept in paediatric oncology. Therefore, PPRL strategies should already be considered when starting research projects, to avoid distributed data silos, to maximise the knowledge derived from collected data, and, ultimately, to improve outcomes for children with cancer. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial
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Ladenstein, Ruth, Pötschger, Ulrike, Valteau-Couanet, Dominique, Luksch, Roberto, Castel, Victoria, Yaniv, Isaac, Laureys, Genevieve, Brock, Penelope, Michon, Jean Marie, Owens, Cormac, Trahair, Toby, Chan, Godfrey Chi Fung, Ruud, Ellen, Schroeder, Henrik, Beck Popovic, Maja, Schreier, Guenter, Loibner, Hans, Ambros, Peter, Holmes, Keith, Castellani, Maria Rita, Gaze, Mark N, Garaventa, Alberto, Pearson, Andrew D J, and Lode, Holger N
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- 2018
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36. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
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Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., Brown, Morven, Diallo, Ibrahima, Feijen, Elizabeth A.M. (Lieke), Fidler, Miranda M., Frey, Eva, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Hagberg, Oskar, Harila-Saari, Arja, Hau, Eva M., Haupt, Riccardo, Hawkins, Mike M., Jakab, Zsuzsanna, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kremer, Leontien C.M., Kuehni, Claudia E., Kuonen, Rahel, Ladenstein, Ruth, Lähteenmäki, Päivi Maria, Levitt, Gill, Linge, Helena, LLanas, Damien, Michel, Gisela, Morsellino, Vera, Mulder, Renee L., Reulen, Raoul C., Ronckers, Cécile M., Sacerdote, Carlotta, Skinner, Roderick, Steliarova-Foucher, Eva, van der Pal, Helena J., de Vathaire, Florent, Vũ Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L., Winther, Jeanette Falck, Witthoff, Elise, Zadravec Zaletel, Lorna, and Hjorth, Lars
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- 2018
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37. The ‘Survivorship Passport’ for childhood cancer survivors
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Menoni, Stefania, Bergeron, Christophe, den Hartogh, Jaap, Karner, Sabine, Fresneau, Brice, Jones, Kathy Pritchard, Vassal, Gilles, Bode, Gerlind, Frey, Eva, Hennewig, Ulrike, Iris, Maia, Jakab, Zsuzsanna, Kosmidis, Helen, Kriviene, Izolda, Marquez, Catalina, Modan-Moses, Dalit, Panasiuk, Anna, Vetsch, Janine, Haupt, Riccardo, Essiaf, Samira, Dellacasa, Chiara, Ronckers, Cecile M., Caruso, Silvia, Sugden, Elaine, Zadravec Zaletel, Lorna, Muraca, Monica, Morsellino, Vera, Kienesberger, Anita, Blondeel, Anne, Saraceno, Davide, Ortali, Maurizio, Kremer, Leontien C.M., Skinner, Roderick, Roganovic, Jelena, Bagnasco, Francesca, Levitt, Gill A., De Rosa, Marisa, Schrappe, Martin, Hjorth, Lars, and Ladenstein, Ruth
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- 2018
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38. Challenges and Opportunities for International Cooperative Studies in Pediatric Hematopoeitic Cell Transplantation: Priorities of the Westhafen Intercontinental Group
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Schultz, Kirk R, Baker, Kevin Scott, Boelens, Jaap J, Bollard, Catherine M, Egeler, R Maarten, Cowan, Mort, Ladenstein, Ruth, Lankester, Arjan, Locatelli, Franco, Lawitschka, Anita, Levine, John E, Loh, Mignon, Nemecek, Eneida, Niemeyer, Charlotte, Prasad, Vinod K, Rocha, Vanderson, Shenoy, Shalini, Strahm, Brigitte, Veys, Paul, Wall, Donna, Bader, Peter, Grupp, Stephan A, Pulsipher, Michael A, and Peters, Christina
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Pediatric ,Clinical Trials and Supportive Activities ,Pediatric Research Initiative ,Stem Cell Research ,Clinical Research ,Hematology ,Transplantation ,Regenerative Medicine ,Adolescent ,Age Factors ,Child ,Hematopoietic Stem Cell Transplantation ,Humans ,International Cooperation ,Transplantation ,Homologous ,Pediatrics ,Hematopoietic cell transplantation ,Clinical Sciences ,Immunology ,Cardiovascular medicine and haematology - Abstract
More than 20% of allogeneic hematopoietic cell transplantations (HCTs) are performed in children and adolescents at a large number of relatively small centers. Unlike adults, at least one-third of HCTs in children are performed for rare, nonmalignant indications. Clinical trials to improve HCT outcomes in children have been limited by small numbers and these pediatric-specific features. The need for a larger number of pediatric HCT centers to participate in trials has led to the involvement of international collaborative groups. Representatives of the Pediatric Blood and Marrow Transplant Consortium, European Group for Blood and Marrow Transplantation's Pediatric Working Group, International Berlin-Frankfurt-Munster (iBFm) Stem Cell Transplantation Committee, and Children's Oncology Group's Hematopoietic Stem Cell Transplantation Discipline Committee met on October 3, 2012, in Frankfurt, Germany to develop a consensus on the highest priorities in pediatric HCT. In addition, it explored the creation of an international consortium to develop studies focused on HCT in children and adolescents. This meeting led to the creation of an international HCT network, dubbed the Westhafen Intercontinental Group, to develop worldwide priorities and strategies to address pediatric HCT issues. This review outlines the priorities of need as identified by this consensus group.
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- 2013
39. Supplementary Figure S2 from Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial
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Koch, Raphael, primary, Haveman, Lianne, primary, Ladenstein, Ruth, primary, Brichard, Benedicte, primary, Jürgens, Heribert, primary, Cyprova, Sona, primary, van den Berg, Henk, primary, Hassenpflug, Wolf, primary, Raciborska, Anna, primary, Ek, Torben, primary, Baumhoer, Daniel, primary, Egerer, Gerlinde, primary, Kager, Leo, primary, Renard, Marleen, primary, Hauser, Peter, primary, Burdach, Stefan, primary, Bovee, Judith V.M.G., primary, Hong, Angela M., primary, Reichardt, Peter, primary, Kruseova, Jarmila, primary, Streitbürger, Arne, primary, Kühne, Thomas, primary, Kessler, Torsten, primary, Bernkopf, Marie, primary, Butterfaß-Bahloul, Trude, primary, Dhooge, Catharina, primary, Bauer, Sebastian, primary, Kiss, János, primary, Paulussen, Michael, primary, Bonar, Fiona, primary, Ranft, Andreas, primary, Timmermann, Beate, primary, Rascon, Jelena, primary, Vieth, Volker, primary, Kanerva, Jukka, primary, Faldum, Andreas, primary, Hartmann, Wolfgang, primary, Hjorth, Lars, primary, Bhadri, Vivek A., primary, Metzler, Markus, primary, Gelderblom, Hans, primary, and Dirksen, Uta, primary
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- 2023
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40. Supplementary Data S2 from Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial
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Koch, Raphael, primary, Haveman, Lianne, primary, Ladenstein, Ruth, primary, Brichard, Benedicte, primary, Jürgens, Heribert, primary, Cyprova, Sona, primary, van den Berg, Henk, primary, Hassenpflug, Wolf, primary, Raciborska, Anna, primary, Ek, Torben, primary, Baumhoer, Daniel, primary, Egerer, Gerlinde, primary, Kager, Leo, primary, Renard, Marleen, primary, Hauser, Peter, primary, Burdach, Stefan, primary, Bovee, Judith V.M.G., primary, Hong, Angela M., primary, Reichardt, Peter, primary, Kruseova, Jarmila, primary, Streitbürger, Arne, primary, Kühne, Thomas, primary, Kessler, Torsten, primary, Bernkopf, Marie, primary, Butterfaß-Bahloul, Trude, primary, Dhooge, Catharina, primary, Bauer, Sebastian, primary, Kiss, János, primary, Paulussen, Michael, primary, Bonar, Fiona, primary, Ranft, Andreas, primary, Timmermann, Beate, primary, Rascon, Jelena, primary, Vieth, Volker, primary, Kanerva, Jukka, primary, Faldum, Andreas, primary, Hartmann, Wolfgang, primary, Hjorth, Lars, primary, Bhadri, Vivek A., primary, Metzler, Markus, primary, Gelderblom, Hans, primary, and Dirksen, Uta, primary
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- 2023
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41. Supplementary Table S5 from Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial
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Koch, Raphael, primary, Haveman, Lianne, primary, Ladenstein, Ruth, primary, Brichard, Benedicte, primary, Jürgens, Heribert, primary, Cyprova, Sona, primary, van den Berg, Henk, primary, Hassenpflug, Wolf, primary, Raciborska, Anna, primary, Ek, Torben, primary, Baumhoer, Daniel, primary, Egerer, Gerlinde, primary, Kager, Leo, primary, Renard, Marleen, primary, Hauser, Peter, primary, Burdach, Stefan, primary, Bovee, Judith V.M.G., primary, Hong, Angela M., primary, Reichardt, Peter, primary, Kruseova, Jarmila, primary, Streitbürger, Arne, primary, Kühne, Thomas, primary, Kessler, Torsten, primary, Bernkopf, Marie, primary, Butterfaß-Bahloul, Trude, primary, Dhooge, Catharina, primary, Bauer, Sebastian, primary, Kiss, János, primary, Paulussen, Michael, primary, Bonar, Fiona, primary, Ranft, Andreas, primary, Timmermann, Beate, primary, Rascon, Jelena, primary, Vieth, Volker, primary, Kanerva, Jukka, primary, Faldum, Andreas, primary, Hartmann, Wolfgang, primary, Hjorth, Lars, primary, Bhadri, Vivek A., primary, Metzler, Markus, primary, Gelderblom, Hans, primary, and Dirksen, Uta, primary
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- 2023
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42. Study Protocol S1 from Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial
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Koch, Raphael, primary, Haveman, Lianne, primary, Ladenstein, Ruth, primary, Brichard, Benedicte, primary, Jürgens, Heribert, primary, Cyprova, Sona, primary, van den Berg, Henk, primary, Hassenpflug, Wolf, primary, Raciborska, Anna, primary, Ek, Torben, primary, Baumhoer, Daniel, primary, Egerer, Gerlinde, primary, Kager, Leo, primary, Renard, Marleen, primary, Hauser, Peter, primary, Burdach, Stefan, primary, Bovee, Judith V.M.G., primary, Hong, Angela M., primary, Reichardt, Peter, primary, Kruseova, Jarmila, primary, Streitbürger, Arne, primary, Kühne, Thomas, primary, Kessler, Torsten, primary, Bernkopf, Marie, primary, Butterfaß-Bahloul, Trude, primary, Dhooge, Catharina, primary, Bauer, Sebastian, primary, Kiss, János, primary, Paulussen, Michael, primary, Bonar, Fiona, primary, Ranft, Andreas, primary, Timmermann, Beate, primary, Rascon, Jelena, primary, Vieth, Volker, primary, Kanerva, Jukka, primary, Faldum, Andreas, primary, Hartmann, Wolfgang, primary, Hjorth, Lars, primary, Bhadri, Vivek A., primary, Metzler, Markus, primary, Gelderblom, Hans, primary, and Dirksen, Uta, primary
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- 2023
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43. Development of a centralised triage centre for children with cancer and blood disorders in response to the humanitarian crisis in Ukraine
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Salek, Marta, primary, Mueller, Alexandra, additional, Alanbousi, Inna, additional, Cepowska, Zuzanna, additional, Dutkiewicz, Malgorzata, additional, Earl, Julian, additional, Evseev, Dmitry, additional, Kizyma, Roman, additional, Kliuchkivska, Khrystyna, additional, Kolodrubiec, Julia, additional, Matczak, Katarzyna, additional, Nogovitsyna, Yuliya, additional, Oszer, Aleksandra, additional, Pogorelyy, Mikhail, additional, Raciborska, Anna, additional, Rasul, Suheir, additional, Sokolowski, Igor, additional, Sopilnyak, Andriy, additional, Vinitsky, Anna, additional, Wlodarski, Marcin W, additional, Wobst, Natalia, additional, Yakimkova, Taisiya, additional, Rodriguez-Galindo, Carlos, additional, Wise, Paul H, additional, Mlynarski, Wojciech, additional, Agulnik, Asya, additional, Alexander, Sarah Weeks, additional, Apel, Anna, additional, Adyrov, Mykhaylo V, additional, Avula, Meghana, additional, Bal, Wioletta Anna, additional, Balwierz, Walentyna Aniela, additional, Basset-Salom, Luisa, additional, Bastardo Blanco, Daniel, additional, Bauer, Karolina Jadwiga, additional, Bayazitov, Ildar T, additional, Berlanga, Pablo, additional, Bhakta, Nickhill Hitesh, additional, Bieniek, Katarzyna Anna, additional, Bien, Ewa Iwona, additional, Blackwood, Christopher Andrew, additional, Blair, Sally Jane, additional, Bodak, Khrystyna Ihorivna, additional, Bordeianu, Irina, additional, Bouffet, Eric, additional, Braganca, Joao Maria, additional, Bucurenci, Mihaela Silvia, additional, Budny, Elżbieta Beata, additional, Budzyn, Andrii, additional, Bumgardner, Christopher Carl, additional, Burditt, Raina Nichole, additional, Burnside Clapp, Victoria, additional, Bykov, Viacheslav Valeriyovych, additional, Cañete, Adela, additional, Carnelli, Monica, additional, Cela, Elena, additional, Chaber, Radoslaw, additional, Cherner-Drieux, Anna, additional, Chubata, Mariya, additional, Clough, Heidi M, additional, Czauderna, Piotr Stefan, additional, Czernicka - Siwecka, Jolanta, additional, Czyzewski, Krzysztof, additional, Dalle, Jean-Hugues, additional, Dashchakovska, Olha, additional, de Koning, Linda A, additional, Dembowska-Baginska, Bozenna Malgorzata, additional, Derwich, Katarzyna, additional, Dirksen, Uta, additional, Dommett, Rachel, additional, Dorosh, Olha Ihorivna, additional, dos Reis Farinha, Nuno Jorge, additional, Drabko, Katarzyna Anna, additional, Dragomir, Monica Desiree, additional, Dworzak, Michael, additional, Dyma, Sergii Vitaliiovych, additional, Eggert, Angelika, additional, English, Martin William, additional, Farren, Becky S, additional, Fedyk, Nataliia Yuriina, additional, Fernández-Teijeiro, Ana, additional, Ferneza, Severyn Romanovych, additional, Foster, Whitney Baer, additional, Fox Irwin, Leeanna Elizabeth, additional, Gałązkowski, Robert Maciej, additional, Ganieva, Galyna, additional, Garanzha, Vasylyna Andriivna, additional, Gelman, Marina S, additional, Godzinski, Jan Krzysztof, additional, Goeres, Anne Françoise, additional, Golban, Rodica, additional, Graetz, Dylan Elizabeth, additional, Greiner, Jeanette, additional, Griksaitis, Michael J, additional, Gupta, Sumit, additional, Hampel, Michal Andrzej, additional, Hastings, Sara Grace, additional, Heenen, Delphine Liliane, additional, Hill, Marcela C, additional, Holiuk, Ihor, additional, Holter, Wolfgang, additional, Hough, Rachael Emma, additional, Hutnik, Lukasz Marek, additional, Irga-Jaworska, Ninela, additional, Istomin, Oleksandr Andriyovych, additional, Ignatova, Anna, additional, Janczar, Szymon Lech, additional, Kacharian, Arman, additional, Kalwak, Krzysztof, additional, Karolczyk, Grażyna Małgorzata, additional, Karpenko, Nataliia Mikolaivna, additional, Katsubo, Halyna Oleksandrivna, additional, Kattamis, Antonis, additional, Kazanowska, Bernarda Jadwiga, additional, Kentsis, Alex, additional, Ketteler, Petra, additional, Kienesberger, Anita, additional, Kiselev, Roman, additional, Kizyma, Zoryana Petrivna, additional, Klymniuk, Hryhorii Ivanovych, additional, Kolenova, Alexandra, additional, Kostiuk, Yuliia, additional, Kowalik, Tomasz, additional, Kozlova, Olena Igorivna, additional, Kozubenko, Vladyslav, additional, Kraal, Kathelijne, additional, Kramar, Tetyana Oleksandrivna, additional, Krawczuk-Rybak, Maryna Maryna, additional, Kulemzina, Irina, additional, Kurkowska, Paulina, additional, Kuzyk, Andriy S., additional, Ladenstein, Ruth Lydia, additional, Laguna, Pawel Jozef, additional, Lassaletta, Alvaro, additional, Lehmberg, Kai, additional, Leontieva, Oksana, additional, Liashenko, Serhii, additional, Loizou, Loizos G., additional, Lucchetta, Sonia Anna, additional, Lupo, Matthew William, additional, Lysytsia, Lesya, additional, Lysytsia, Oleksandr, additional, Machnik, Katarzyna Anna, additional, Massimino, Maura, additional, Mainland, Jeff A, additional, Matysiak, Michal Jacek, additional, Mayeur, Pierre, additional, Miller, Beth Anne, additional, Minervina, Anastasia A, additional, Mishkova, Volha, additional, Mizia-Malarz, Agnieszka Joanna, additional, Morales La Madrid, Andres, additional, Moreira, Daniel C, additional, Moreno, Lucas, additional, Moskvin, Vadim P, additional, Mukkada, Sheena Teresa, additional, Muszyńska-Rosłan, Katarzyna Maria, additional, Mykychak, Iryna Volodymyrivna, additional, Niemeyer, Charlotte, additional, Nelson, Akoya Janae', additional, Ociepa, Tomasz, additional, Oltolini, Stefano, additional, Onipko, Nataliia, additional, Pappas, Andrew, additional, Patel, Amit B, additional, Patrahau, Alina Alina, additional, Pauley, Jennifer L., additional, Pavlenko, Yehor Mikhailovich, additional, Pavlovych, Andrij Oleksandrovych, additional, Peregud-Pogorzelski, Jarosław Władysław, additional, Perek-Polnik, Marta, additional, Pérez, Vanesa, additional, Pérez-Martínez, Antonio, additional, Pikman, Yana, additional, Pitozzi, Graziano Pitozzi, additional, Portugal, Rui Gentil, additional, Posternak, Victoria Vita, additional, Pleshkan, Viktoriya, additional, Prete, Arcangelo, additional, Pritchard-Jones, Kathy, additional, Radaelli, Alessandra, additional, Reeves, Tegan Jemma, additional, Reinhardt, Dirk, additional, Reshetnyak, Andrey V, additional, Rider, Andrew Jacob, additional, Rizzari, Carmelo, additional, Rizzi, Damiano Damiano, additional, Rodriguez Hermosillo, Karen Gabriela, additional, Ronenko, Olena Volodymyrivna, additional, Rostkowska, Aneta Olga, additional, Rudko, Liudmyla Yaroslavivna, additional, Sakaan, Firas Mohamed, additional, Sakhar, Nadezhda Aleksandrovna, additional, Salman, Zeena S, additional, Savva, Natallia N, additional, Scaccaglia, Davide, additional, Schaeffer, Elizabeth Hawthorne, additional, Schneider, Carina Ursula, additional, Scobie, Nicole, additional, Semeniuk, Olena Volodymyrivna, additional, Shevchyk, Roksoliana, additional, Shuler, Ana, additional, Shvets, Stanislav, additional, Sniderman, Liz, additional, Skoczen, Szymon Pawel, additional, Smeal, William John, additional, Sonkin, Anna Alexandra, additional, Spota, Andrea, additional, Sramkova, Lucie, additional, Stepanjuk, Alla Ivanivna, additional, Sterba, Jaroslav, additional, Strahm, Brigitte, additional, Styczynski, Jan, additional, Svintsova, Olha, additional, Synyuta, Andriy V, additional, Szczepanski, Tomasz, additional, Szczucinski, Paweł Kukiz, additional, Szmyd, Bartosz Miroslaw, additional, Tasso Cereceda, Maria, additional, Teliuk, Alina, additional, Tomanek, Iwona, additional, Topping, Phoebe, additional, Torrent, Montserrat, additional, Trelińska, Joanna, additional, Troyanovska, Olha Orestivna, additional, Tsurkan, Lyudmila G., additional, Tsymbalyuk-Voloshyn, Iryna, additional, Tyupa, Sergiy Ihorovych, additional, Urasinski, Tomasz Franciszek, additional, Urbanek Dądela, Agnieszka, additional, Vasilieva, Nataliia Jroslavivna, additional, Vasilyeva, Aksana, additional, Verdú-Amorós, Jaime, additional, Vilcu-Bajurean, Natalia, additional, Vinitsky, Leo, additional, Vivtcharenko, Victoria, additional, Vovk, Nelia, additional, Volpe, Giovanni, additional, Vorobel, Oksana Ivanivna, additional, Wachowiak, Jacek Tadeusz, additional, Wasiak, Marcin Sławomir, additional, Wiedower, Lance Allan, additional, Wuenschel, Lena Isolde, additional, Wysocki, Mariusz Stanislaw, additional, Yurieva, Marina, additional, Zagurska, Anastasiia, additional, Zakharenko, Stanislav S, additional, Zakharenko, Aelita V, additional, Zapotochna, Khrystyna, additional, Zawitkowska, Joanna Emilia, additional, and Zecca, Marco, additional
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- 2023
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44. Zoledronic acid add-on therapy for standard-risk Ewing sarcoma patients in the Ewing 2008R1 trial
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Koch, Raphael, primary, Haveman, Lianne, additional, Ladenstein, Ruth, additional, BRICHARD, Bénédicte, additional, Juergens, Heribert, additional, Cyprová, Soňa, additional, van den Berg, Henk, additional, Hassenpflug, Wolf, additional, Raciborska, Anna, additional, Ek, Torben, additional, Baumhoer, Daniel, additional, Egerer, Gerlinde, additional, Kager, Leo, additional, Renard, Marleen, additional, Hauser, Peter, additional, Burdach, Stefan, additional, Bovee, Judith V.M.G., additional, Hong, Angela M., additional, Reichardt, Peter, additional, Kruseova, Jarmila, additional, Streitbürger, Arne, additional, Kühne, Thomas, additional, Kessler, Torsten, additional, Bernkopf, Marie, additional, Butterfaß-Bahloul, Trude, additional, Dhooge, Catharina, additional, Bauer, Sebastian, additional, Kiss, János, additional, Paulussen, Michael, additional, Bonar, Fiona, additional, Ranft, Andreas, additional, Timmermann, Beate, additional, Rascon, Jelena, additional, Vieth, Volker, additional, Kanerva, Jukka, additional, Faldum, Andreas, additional, Hartmann, Wolfgang, additional, Hjorth, Lars, additional, Bhadri, Vivek A., additional, Metzler, Markus, additional, Gelderblom, Hans, additional, and Dirksen, Uta, additional
- Published
- 2023
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45. Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial
- Author
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Ladenstein, Ruth, Pötschger, Ulrike, Pearson, Andrew D J, Brock, Penelope, Luksch, Roberto, Castel, Victoria, Yaniv, Isaac, Papadakis, Vassilios, Laureys, Geneviève, Malis, Josef, Balwierz, Walentyna, Ruud, Ellen, Kogner, Per, Schroeder, Henrik, de Lacerda, Ana Forjaz, Beck-Popovic, Maja, Bician, Pavel, Garami, Miklós, Trahair, Toby, Canete, Adela, Ambros, Peter F, Holmes, Keith, Gaze, Mark, Schreier, Günter, Garaventa, Alberto, Vassal, Gilles, Michon, Jean, and Valteau-Couanet, Dominique
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- 2017
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46. PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers
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Martí-Bonmatí, Luis, Alberich-Bayarri, Ángel, Ladenstein, Ruth, Blanquer, Ignacio, Segrelles, J. Damian, Cerdá-Alberich, Leonor, Gkontra, Polyxeni, Hero, Barbara, García-Aznar, J. M., Keim, Daniel, Jentner, Wolfgang, Seymour, Karine, Jiménez-Pastor, Ana, González-Valverde, Ismael, Martínez de las Heras, Blanca, Essiaf, Samira, Walker, Dawn, Rochette, Michel, Bubak, Marian, Mestres, Jordi, Viceconti, Marco, Martí-Besa, Gracia, Cañete, Adela, Richmond, Paul, Wertheim, Kenneth Y., Gubala, Tomasz, Kasztelnik, Marek, Meizner, Jan, Nowakowski, Piotr, Gilpérez, Salvador, Suárez, Amelia, Aznar, Mario, Restante, Giuliana, and Neri, Emanuele
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- 2020
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47. Childhood Cancer Survivorship Passport Challenges in the European Health Data Space.
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GAZZARATA, Roberta, STRÜBIN, Michael, CHRONAKI, Catherine, CANGIOLI, Giorgio, SARACENO, Davide, SCHREIER, Günter, BEYER, Stefan, TRAUNER, Florian, GREDINGER, Gerald, LADENSTEIN, Ruth, de BEIJER, Ismay AE, CAVALCA, Giacomo, TRINKUNAS, Justas, BELTRAN, Lucas CERVERO, VANAUTGAERDEN, Mark, KOCK-SCHOPPENHAUER, Ann-Kristin, NEUMANN, Anke, MURACA, Monica, FILBERT, Anna-Liesa, and HAUPT, Riccardo
- Abstract
Innovation in cancer therapy has increased childhood cancer survival rates. However, survivors are still at risk of developing late effects. In the digital transformation of the health sector, the Survivorship Passport (SurPass) can support long-term follow-up care plans. Gaps in seamless connectivity among hospital departments, primary care, combined with the time of health professionals required to collect and fill-in health data in SurPass, are barriers to its adoption in daily clinical practice. The PanCareSurPass (PCSP) project was motivated to address these gaps by a new version of SurPass (v2.0) that supports semi-automatic assembly from organizational Electronic Health Record (EHR) systems of the treatment summary data using HL7 FHIR, to create SurPass, and to link it to regional or national digital health infrastructures in six European countries. In this paper we present the methodology used to develop the SurPass technical implementation strategy with special focus on the European Health Data Space (EHDS). The recently provisionally approved EHDS regulation instruments a digital health data ecosystem with opportunities for cost-effective SurPass implementation across Europe. Moving forward, a European HL7 FHIR SurPass Implementation Guide along with synthetic data sets, and validation tools can enrich the European Electronic Health Record Exchange Format (EEHRxF) with use cases on health & wellness of childhood cancer survivors. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Assessment of HL7 FHIR Interoperability Between EHR Systems and the Survivorship Passport v2.0 Platform to Generate Treatment Summaries for Childhood Cancer Survivors in Six Clinics: Preliminary Testing Results.
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SARACENO, Davide, CHRONAKI, Catherine, CANGIOLI, Giorgio, FILBERT, Anna-Liesa, MURACA, Monica, BERTI, Alessandra, RIELLI, Rita, THOMOPULOS, Nikos, KNOERR, Lisa, WALZ, Diana, NEUMANN, Anke, BECCARIA, Andrea, AULICINO, Anna, NICOLAS, Brigitte, CAVALCA, Giacomo, UYTTEBROECK, Anne, VAN HELVOIRT, Maria, BRIÉ, Tom, MEERSCH, Erik VANDEN, and LADENSTEIN, Ruth
- Abstract
The Survivorship Passport (SurPass) for childhood cancer survivors provides a personalized treatment summary together with a care plan for long-term screening of possible late effects. HL7 FHIR connectivity of Electronic Health Record (EHR) systems with the SurPass has been proposed to reduce the burden of collecting and organizing the relevant information. We present the results of testing and validation efforts conducted across six clinics in Austria, Belgium, Germany, Italy, Lithuania, and Spain. We also discuss ways in which this experience can be used to reduce efforts for the SurPass integration in other clinics across Europe. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Bevacizumab, Irinotecan, or Topotecan Added to Temozolomide for Children With Relapsed and Refractory Neuroblastoma: Results of the ITCC-SIOPEN BEACON-Neuroblastoma Trial.
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Moreno, Lucas, Weston, Rebekah, Owens, Cormac, Valteau-Couanet, Dominique, Gambart, Marion, Castel, Victoria, Zwaan, C. Michel, Nysom, Karsten, Gerber, Nicolas, Castellano, Aurora, Laureys, Genevieve, Ladenstein, Ruth, Rössler, Jochen, Makin, Guy, Murphy, Dermot, Morland, Bruce, Vaidya, Sucheta, Thebaud, Estelle, van Eijkelenburg, Natasha, and Tweddle, Deborah A.
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- 2024
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50. Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study
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Berbegall, Ana P., Bogen, Dominik, Pötschger, Ulrike, Beiske, Klaus, Bown, Nick, Combaret, Valérie, Defferrari, Raffaella, Jeison, Marta, Mazzocco, Katia, Varesio, Luigi, Vicha, Ales, Ash, Shifra, Castel, Victoria, Coze, Carole, Ladenstein, Ruth, Owens, Cormac, Papadakis, Vassilios, Ruud, Ellen, Amann, Gabriele, Sementa, Angela R., Navarro, Samuel, Ambros, Peter F., Noguera, Rosa, and Ambros, Inge M.
- Published
- 2018
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