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2. The 'Hub and Spoke' model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Cristina Bucci, L. Amitrano, C. Londoni, A. Chirico, O. Triossi, A. Zambelli, F. Bazzoli, B. Germanà, F. Cipolletta, Marco Soncini, S. Mangiafico, F. Parente, E Di-Giulio, A. Andriulli, G. D'Amico, G. Baldassarre, Riccardo Marmo, A. Repici, A. Paterlini, G. Imperiali, Angelo Zullo, V Annese, F. De Nigris, R. Bennato, S. Metrangolo, L. Orsini, S. Bargiggia, I Sorrentino, M. Manno, Maria Elena Riccioni, C. Tomba, A. Nucci, A. Bizzotto, FR De-Filippo, A. Merighi, Guido Costamagna, R de-Franchis, C. Marmo, A. Anderloni, L.G. Cavallaro, P Esposito, A. Russo, R. Pumpo, D. Conte, M.A. Bianco, F Buffoli, L. Cipolletta, R. Conigliaro, P Di-Giorgio, A Filippino, G. Bresci, F Covello, P. Borgheresi, L.M. Montalbano, R.M. Zagari, E. Buscarini, Annalisa Tortora, D. Spotti, L. Ferraris, R. Lamanda, M. Franceschi, G Castrignanò, G. Spinzi, A. Lauri, S. Segato, R Grassia, V. Boarino, P. Cesaro, C De-Fanis, R. Meroni, G. Napolitano, L. Furio, AG Bonanomi, M De-Matthaeis, M. Parravicini, A Dell‘Era, L. Purita, Marmo R., Soncini M., Bucci C., Zullo A., Amitrano L., Anderloni A., Andriulli A., Annese V., Baldassarre G., Bargiggia S., Bazzoli F., Bennato R., Bianco M.A., Bizzotto A., Boarino V., Bonanomi A.G., Borgheresi P., Bresci G., Buffoli F., Buscarini E., Castrignano G., Cavallaro L.G., Cesaro P., Chirico A., Cipolletta F., Cipolletta L., Conigliaro R., Conte D., Costamagna G., Covello F., D'Amico G., De-Fanis C., De-Filippo F.R., de-Franchis R., Dell'Era A., De Nigris F., De-Matthaeis M., Di-Giorgio P., Di-Giulio E., Esposito P., Ferraris L., Filippino A., Franceschi M., Furio L., Germana' B., Grassia R., Imperiali G., Lamanda R., Lauri A., Londoni C., Mangiafico S., Manno M., Marmo C., Merighi A., Meroni R., Metrangolo S., Montalbano L.M., Napolitano G., Nucci A., Orsini L., Parente F., Parravicini M., Paterlini A., Pumpo R., Purita L., Repici A., Riccioni M.E., Russo A., Segato S., Sorrentino I., Spinzi G., Spotti D., Tortora A., Tomba C., Triossi O., Zagari R.M., and Zambelli A.

Subjects
medicine.medical_specialty, Gastrointestinal bleeding, Multivariate analysis, Organizational model, Improved survival, Comorbidity, 03 medical and health sciences, Organizational setting, 0302 clinical medicine, Health care, Spoke-hub distribution paradigm, Medicine, Humans, Hub and spoke network, Mortality, Aged, Hepatology, business.industry, Delivery of Health Care, Integrated, Gastroenterology, Acute upper gastrointestinal bleeding, Length of Stay, Middle Aged, medicine.disease, Italy, 030220 oncology & carcinogenesis, Case-Control Studies, Emergency medicine, 030211 gastroenterology & hepatology, business, Gastrointestinal Hemorrhage, Acute gastrointestinal bleeding, Cohort study
Abstract

Background: the lack of standardized pathways for patients with gastrointestinal bleeding may have led to differences in their management and inequity to medical care access. The "Hub & Spoke" model was adopted to fill this gap in many disciplines, but, to our knowledge, no data exist on its efficacy on mortality in GI bleeding. We aimed to evaluate if the "Hub & Spoke" organizational model has an impact on mortality risk from UGIB. Methods: from January 2014 to December 2015, 3324 consecutive patients admitted for UGIB in 50 Italian hospitals were enrolled (1977 patients in hospitals within the "Hub & Spoke" network for digestive hemorrhagic emergency and 1347 in hospitals outside the "Hub & Spoke" network). Clinical, endoscopic and organizational data were recorded. Results: we observed no differences in mortality between patients admitted to hospitals included or not included in the "Hub & Spoke" network (5.2% vs 6.1%, p = 0.3). On multivariate analysis, admission in gastroenterology wards (OR 0.61, p = 0.001) or an academic hospital (OR 0.65, p < 0.056) were independent protective factors while being in "Hub & Spoke" organization system did not affect mortality (OR 1.09, p = 0.57). Conclusion: the "Hub & Spoke" model per sé does not impact on mortality while being treated in academic hospital or gastroenterology wards improved survival.

Published
2021

3. OC.10.1 THE USE OF PRE-ENDOSCOPIC INTRAVENOUS PROTON PUMP INHIBITORS (PPIS) HAD NO IMPACT ON CLINICAL OUTCOMES IN ACUTE UPPER GASTROINTESTINAL BLEEDING: A PROSPECTIVE MULTICENTER ITALIAN COHORT STUDY

Author

A. Andriulli, R. Pumpo, G. Spinzi, L. Amitrano, G. Baldassarre, Marco Soncini, Riccardo Marmo, M. De Matthaeis, C. Londoni, L. Furio, L. Ferraris, S. Metrangolo, A. Balzano, L.G. Cavallaro, G. D'Amico, A. Lauri, E. Buscarini, V. Boarino, A. Merighi, B. Germanà, D. Spotti, P. Di Giorgio, L. Orsini, G. Imperiali, R. Lamanda, F. De Nigris, Alessandra Dell'Era, S. Bargiggia, D. Conte, F. Cipolletta, A. Nucci, P. Cesaro, A. Bizzotto, F.R. De Filippo, A. Anderloni, Maria Elena Riccioni, C. Marmo, A. Repici, A. Paterlini, A. Chirico, G. Napolitano, S. Mangiafico, C. De Fanis, O. Triossi, G. Rotondano, Annalisa Tortora, Guido Costamagna, F. Esposito, P. Borgheresi, L.M. Montalbano, E. Di Giulio, M. Franceschi, Cristina Bucci, R. Bennato, M. Manno, L. Purita, L. Cipolletta, R. Conigliaro, R.M. Zagari, R. De Franchis, A. Zambelli, F. Bazzoli, A. Russo, M.A. Bianco, G. Bresci, M. Parravicini, F. Parente, and S. Segato

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Acute upper gastrointestinal bleeding, business, Cohort study
Published
2020
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4. T01.01.7 THE USE OF A SPECIALIZED BLEEDING-MANAGEMENT TEAM HAD NO IMPACT ON MORTALITY FOR ACUTE UPPER GASTROINTESTINAL BLEEDING: AN ITALIAN PROSPECTIVE MULTICENTER COHORT STUDY

Author

L. Purita, S. Segato, L. Ferraris, G. D'Amico, E. Buscarini, G. Imperiali, L. Orsini, F. Parente, Maria Elena Riccioni, P. Borgheresi, L.M. Montalbano, Annalisa Tortora, Guido Costamagna, G. Spinzi, M. Franceschi, S. Mangiafico, A. Balzano, A. Lauri, C. De Fanis, A. Russo, M.A. Bianco, G. Bresci, R.M. Zagari, C. Londoni, A. Andriulli, R. De Franchis, A. Zambelli, F. Bazzoli, L.G. Cavallaro, S. Bargiggia, R. Bennato, D. Conte, M. Manno, F. Esposito, A. Chirico, S. Metrangolo, A. Anderloni, V. Boarino, D. Spotti, O. Triossi, B. Germanà, R. Lamanda, G. Baldassarre, P. Cesaro, M. Parravicini, Cristina Bucci, L. Cipolletta, R. Conigliaro, F. Cipolletta, Alessandra Dell'Era, A. Repici, A. Paterlini, F. De Nigris, G. Napolitano, R. Pumpo, A. Nucci, Marco Soncini, A. Merighi, Riccardo Marmo, A. Bizzotto, F.R. De Filippo, C. Marmo, G. Rotondano, L. Furio, E. Di Giulio, L. Amitrano, M. De Matthaeis, and P. Di Giorgio

Subjects
medicine.medical_specialty, Hepatology, business.industry, Emergency medicine, Gastroenterology, Medicine, Acute upper gastrointestinal bleeding, business, Cohort study
Published
2020
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5. Lowest Case Fatality Rate for Patients with Acute Pancreatitis Admitted in Gastroenterology Units in Veneto Region, Italy

Author

Luca Frulloni, L.G. Cavallaro, Fabio Farinati, M. Saia, Armando Gabbrielli, Marino Venerito, and Bastianello Germanà

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Hospital unit, Gastroenterology, hospital unit, hospitalization, invasive treatment, length of stay, mortality, volume hospitals, 03 medical and health sciences, Patient Admission, 0302 clinical medicine, Endocrinology, Intensive care, Internal medicine, Case fatality rate, Internal Medicine, Humans, Medicine, Hospital Mortality, Aged, Retrospective Studies, Aged, 80 and over, Hepatology, business.industry, Incidence, Incidence (epidemiology), Retrospective cohort study, Odds ratio, Middle Aged, medicine.disease, Patient Discharge, Confidence interval, Italy, Pancreatitis, 030220 oncology & carcinogenesis, Acute Disease, Acute pancreatitis, Female, 030211 gastroenterology & hepatology, business
Abstract

OBJECTIVES This study aimed to evaluate trends in hospitalizations and outcomes of acute pancreatitis (AP) according to first admitting hospital unit and hospital volumes. METHODS Hospital discharge records of patients with AP admitted in the Veneto Region (Northeast Italy) during the period 2001-2015 were examined. RESULTS A total of 23,389 patients (54% males; mean age, 62.2 years; standard deviation, 19.3 years) were admitted for AP. Both hospitalization (32.4 to 29.5/100,000 inhabitants per year; P < 0.05) and in-hospital mortality (1.41 to 0.79/100,000 inhabitants per year; P < 0.05) decreased over the study period. Case fatality rate was altogether 3.2%. The percentages of patients admitted in surgery, nongastroenterology medical units, gastroenterology, and intensive care were 52%, 30%, 16%, and 2%, respectively. Fewer fatalities were observed in gastroenterology units (1.7%) compared with nongastroenterology medical units (4.3%; odds ratio, 0.37; 95% confidence interval, 0.28-0.49) and surgical units (2.7%; odds ratio, 0.61; 95% confidence interval, 0.47-0.80). Fatalities decreased progressively with increasing hospital volumes from 3.7% to 2.9% (P < 0.05). CONCLUSION In the Veneto Region, both hospitalizations and in-hospital mortality for AP significantly decreased over the last 15 years. Case fatality rate was lowest for patients admitted in gastroenterology units.

Published
2019

6. OC.11.5 TRIGGER AND TARGET TRANSFUSION STRATEGY IN PATIENTS WITH NON-VARICEAL ACUTE UPPER GASTROINTESTINAL BLEEDING (NV-AUGIB): A PROSPECTIVE MULTICENTRE OBSERVATIONAL STUDY

Author

L. Amitrano, C. Spada, L. Purita, R. Pumpo, L. Furio, L. Orsini, S. Metrangolo, M. Parravicini, G. D'Amico, F. Esposito, G. Spinzi, R. Bennato, A. Andriulli, A. Merighi, M. Manno, L. Cipolletta, R. Conigliaro, Alessandra Dell'Era, Maria Elena Riccioni, G. Imperiali, A. Lauri, D. Conte, V. Boarino, Guido Costamagna, G. Napolitano, E. Buscarini, G. Baldassarre, P. Cesaro, Cristina Bucci, R. Lamanda, A. Balzano, A. Anderloni, P. Borgheresi, L.M. Montalbano, S. Mangiafico, C. Londoni, A. Russo, C. De Fanis, F. Cipolletta, L. Ferraris, R. De Franchis, A. Zambelli, M.A. Bianco, F. Bazzoli, G. Bresci, L.G. Cavallaro, A. Repici, A. Chirico, O. Triossi, F. Parente, Marco Soncini, Riccardo Marmo, S. Segato, R.M. Zagari, M. De Matthaeis, P. Di Giorgio, F. De Nigris, A. Nucci, A. Bizzotto, F.R. De Filippo, C. Marmo, E. Di Giulio, B. Germanà, G. Rotondano, S. Bargiggia, P. Gasparini, Annalisa Tortora, and M. Franceschi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Observational study, In patient, Acute upper gastrointestinal bleeding, business
Published
2019
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7. Time trends and outcome of gastrointestinal bleeding in the Veneto Region: A retrospective population based study from 2001 to 2010

Author

Fabio Monica, M. Saia, Bastianello Germanà, R. Marin, Giacomo Carlo Sturniolo, and L.G. Cavallaro

Subjects
Male, Time Factors, Gastroenterology, Cohort Studies, Lower gastrointestinal bleeding, HEMORRHAGE, Case fatality rate, EPIDEMIOLOGY, Hospital Mortality, Child, Aged, 80 and over, Incidence, Incidence (epidemiology), Middle Aged, Hospitalization, Treatment Outcome, Italy, Child, Preschool, Female, Gastrointestinal Hemorrhage, Adult, Gastrointestinal bleeding, medicine.medical_specialty, Adolescent, UNITED-STATES, Young Adult, Internal medicine, MANAGEMENT, medicine, Humans, COHORT, Incidence, Lower gastrointestinal bleeding, Mortality, Upper gastrointestinal bleeding, ROCKALL SCORE, UNITED-STATES, HEMORRHAGE, MORTALITY, MANAGEMENT, CONSENSUS, HOSPITALIZATION, EPIDEMIOLOGY, COHORT, Upper gastrointestinal bleeding, Aged, Retrospective Studies, ROCKALL SCORE, Hepatology, Time trends, business.industry, MORTALITY, Infant, Length of Stay, medicine.disease, Patient admissions, Population based study, Logistic Models, Multivariate Analysis, CONSENSUS, business
Abstract

a b s t r a c t Background: Gastrointestinal bleeding is the most frequent emergency for gastroenterologists. Despite advances in management, an improvement in mortality is still not evident. Aim: Determining time trends of gastrointestinal bleeding hospitalization and outcomes from 2001 to 2010 in the Veneto Region (Italy). Patients and methods: Data of patients admitted with gastrointestinal bleeding from Veneto regional discharge records were retrospectively evaluated. Chi-squared and multivariate logistic regression model were used. Results: Overall, 44,343 patients (mean age 64.2 ± 8.6 years) with gastrointestinal bleeding were analysed: 23,450 (52.9%) had upper, 13,800 (31.1%) lower, and 7093 (16%) undefined gastrointestinal bleeding. Admission rate decreased from 108.0 per 100,000 in 2001 to 80.7 in 2010, mainly owing to a decrease in upper gastrointestinal bleeding (64.4 to 35.9 per 100,000, p < 0.05). Reductions in hospital fatality rate (from 5.3% to 3%, p < 0.05), length of hospital stay (from 9.3 to 8.7 days, p < 0.05), and need for surgery (from 5.6% to 5%, p < 0.05) were observed. Surgery (OR: 2.97, 95% CI: 2.59-3.41) and undefined gastrointestinal bleeding (OR: 2.89, 95% CI: 2.62-3.19) were found to be risk factors for mortality. Conclusions: Patient admissions for gastrointestinal bleeding decreased significantly over the years, owing to a decrease in upper gastrointestinal bleeding. Improved outcomes could be related to regional dedi- cated clinical gastroenterological management.

Published
2014
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8. OC.14.2 PREDICTIVE FACTORS OF MORTALITY IN ACUTE GASTROINTESTINAL BLEEDING IN ITALY (AUGIB): A NEW PRE-ENDOSCOPY PROGNOSTIC MODEL FROM A MULTICENTER STUDY

Author

R. Bennato, M. Manno, S. Segato, M. De Matthaeis, L.G. Cavallaro, E. Buscarini, G. D'Amico, P. Di Giorgio, A. Balzano, G. Imperiali, R. De Franchis, A. Zambelli, F. Bazzoli, Guido Costamagna, F. De Nigris, F. Esposito, A. Andriulli, G. Spinzi, A. Nucci, B. Germanà, L. Ferraris, A. Bizzotto, F.R. De Filippo, V. Boarino, Cristina Bucci, C. Marmo, L. Amitrano, L. Orsini, Marco Soncini, Riccardo Marmo, P. Cesaro, R.M. Zagari, F. Parente, Maria Elena Riccioni, R. Lamanda, A. Anderloni, P. Borgheresi, L.M. Montalbano, E. Di Giulio, A. Lauri, S. Mangiafico, A. Russo, S. Metrangolo, R. Pumpo, C. De Fanis, M.A. Bianco, L. Purita, G. Bresci, A. Chirico, O. Triossi, F. Cipolletta, L. Cipolletta, R. Conigliaro, C. Londoni, A. Repici, A. Paterlini, A. Merighi, M. Parravicini, D. Conte, G. Baldassarre, L. Furio, G. Napolitano, A. Dell'Eera, G. Rotondano, Annalisa Tortora, M. Franceschi, S. Bargiggia, and P. Gasparini

Subjects
medicine.medical_specialty, Hepatology, Multicenter study, medicine.diagnostic_test, Acute gastrointestinal bleeding, business.industry, Internal medicine, Gastroenterology, Prognostic model, medicine, business, Endoscopy
Published
2018
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9. P.10.8: Mortality from Acute Upper Gastrointestinal Bleeding (UGIB): The Role of the Organizational and Health Care Course: A Prospective Multicentre Observational Study in Italy

Author

L. Purita, L. Orsini, S. Mangiafico, S. Segato, C. De Fanis, Maria Elena Riccioni, M. Parravicini, L. Furio, F. De Nigris, Cristina Bucci, A. Andriulli, C. Londoni, Guido Costamagna, E. Buscarini, A. Russo, M.A. Bianco, G. Baldassarre, A. Merighi, L. Ferraris, F. Zingone, A. Nucci, B. Germanà, G. Bresci, R. Pumpo, F. Cipolletta, S. Bargiggia, A. Bizzotto, F.R. De Filippo, C. Marmo, A. Repici, F. Esposito, P. Gasparini, R. Bennato, M. Manno, Marco Soncini, A. Chirico, G. Rotondano, G. Spinzi, A. Anderloni, Riccardo Marmo, D. Conte, G. D'Amico, O. Triossi, V. Boarino, A. Lauri, P. Cesaro, S. Metrangolo, A. Balzano, G. Imperiali, P. Borgheresi, L.M. Montalbano, L.G. Cavallaro, M. De Matthaeis, Alessandra Dell'Era, Annalisa Tortora, M. Guardascione, R.M. Zagari, M. Franceschi, L. Cipolletta, R. Conigliaro, P. Di Giorgio, G. Napolitano, R. De Franchis, A. Zambelli, F. Bazzoli, R. Lamanda, and F. Parente

Subjects
medicine.medical_specialty, Hepatology, business.industry, Health care, Gastroenterology, medicine, Observational study, Acute upper gastrointestinal bleeding, Intensive care medicine, business
Published
2017
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10. P.10.10: Mortality Causes from Acute Upper Gastrointestinal Bleeding: A Prospective Multicentre Observational Study

Author

S. Segato, M. De Matthaeis, F. Cipolletta, V. Boarino, A. Repici, A. Paterlini, G. Spinzi, P. Di Giorgio, L. Orsini, P. Cesaro, G. D'Amico, L. Cipolletta, R. Conigliaro, F. De Nigris, G. Imperiali, R. Bennato, A. Lauri, A. Anderloni, Maria Elena Riccioni, Alessandra Dell'Era, A. Nucci, A. Bizzotto, F.R. De Filippo, B. Germanà, M. Manno, C. Marmo, F. Esposito, Guido Costamagna, G. Napolitano, R. Pumpo, R.M. Zagari, A. Russo, L. Furio, A. Balzano, L. Ferraris, M.A. Bianco, E. Di Giulio, G. Bresci, S. Mangiafico, F. Parente, C. De Fanis, L. Purita, S. Bargiggia, Marco Soncini, G. Rotondano, Riccardo Marmo, A. Merighi, M. Parravicini, P. Borgheresi, L.M. Montalbano, M. Guardascione, P. Gasparini, R. De Franchis, A. Zambelli, F. Bazzoli, E. Buscarini, S. Metrangolo, D. Conte, R. Lamanda, G. Baldassarre, Annalisa Tortora, M. Franceschi, A. Andriulli, L.G. Cavallaro, C. Londoni, Cristina Bucci, A. Chirico, and O. Triossi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Observational study, Acute upper gastrointestinal bleeding, business
Published
2017
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11. P.15.3 INCREASED PERFORMANCE OF AN UPDATED ROCKALL SCORE IN ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING: A PROSPECTIVE MULTICENTRE ITALIAN STUDY

Author

E. Masci, S. De Stefano, S. Segato, A. Russo, D. Conte, L.G. Cavallaro, M. Martorano, M.A. Bianco, R.M. Zagari, L. Cipolletta, G. Bresci, R. Marin, G. Spinzi, A. Andreloni, Cristina Bucci, S. Metrangolo, G. Baldassarre, R. Lamanda, A. Lauri, L. Amitrano, G. D'Amico, L. Ferraris, A. Merighi, A. Chirico, C. De Fanis, R. De Franchis, O. Triossi, G. Imperiali, F. Cipolletta, G. Coccia, A. Repici, A. Paterlini, B. Germanà, S. Antoniazzi, E. Buscarini, Alessandra Dell'Era, Annalisa Tortora, M. Franceschi, L. Furio, G. Rotondano, S. Bargiggia, A. Maringhini, P. Gasparini, M. De Matthaeis, P. Di Giorgio, F. De Nigris, A. Nucci, F. Politi, A. Bizzotto, M. Parravicini, P. Borgheresi, L.M. Montalbano, C. Marmo, L. Purita, E. Di Giulio, R. Pumpo, R. Bennato, A. Balzano, Marco Soncini, Riccardo Marmo, V. Boarino, P. Cesaro, F. Parente, and Maria Elena Riccioni

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Gastro intestinal bleeding, business, Rockall score
Published
2016
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12. P.10.9: Outpatient Management of Patients with Glasgow-Blatchford Bleeding Score Low-Risk Upper-Gastrointestinal Hemorrhage: A Multicenter Validation Study in Italy

Author

F. De Nigris, A. Nucci, F. Cipolletta, R. Bennato, A. Bizzotto, F.R. De Filippo, C. Marmo, M. Manno, A. Repici, A. Paterlini, M. De Matthaeis, P. Di Giorgio, S. Segato, E. Di Giulio, R. Lamanda, G. Spinzi, G. Rotondano, M. Guardascione, G. Baldassarre, S. Bargiggia, A. Balzano, S. Mangiafico, L.G. Cavallaro, L. Ferraris, C. De Fanis, P. Gasparini, A. Merighi, R. Pumpo, A. Lauri, S. Metrangolo, Marco Soncini, Riccardo Marmo, L. Furio, A. Chirico, M. Parravicini, B. Germanà, D. Conte, R.M. Zagari, O. Triossi, F. Esposito, Annalisa Tortora, Alessandra Dell'Era, M. Franceschi, V. Boarino, A. Andriulli, R. De Franchis, A. Zambelli, F. Bazzoli, L. Cipolletta, C. Londoni, R. Conigliaro, L. Purita, E. Buscarini, P. Cesaro, G. Napolitano, Cristina Bucci, L. Orsini, P. Borgheresi, L.M. Montalbano, Maria Elena Riccioni, Guido Costamagna, G. D'Amico, G. Imperiali, A. Russo, M.A. Bianco, G. Bresci, A. Anderloni, and F. Parente

Subjects
medicine.medical_specialty, Validation study, Hepatology, business.industry, Gastroenterology, medicine, Upper gastrointestinal, Outpatient management, Intensive care medicine, business
Published
2017
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13. P.10.3: Mortality in Upper Gastrointestinal Bleeding in Italy: Data from National Survey

Author

A. Chirico, O. Triossi, Cristina Bucci, C. Londoni, S. Mangiafico, Guido Costamagna, M. De Matthaeis, C. De Fanis, F. Cipolletta, G. Baldassarre, A. Andriulli, A. Balzano, A. Repici, A. Paterlini, F. Parente, V. Boarino, R. Lamanda, A. Russo, P. Di Giorgio, S. Segato, M.A. Bianco, R. Bennato, G. Bresci, P. Cesaro, M. Manno, G. D'Amico, G. Spinzi, E. Di Giulio, G. Imperiali, L. Orsini, F. De Nigris, L. Cipolletta, R. Conigliaro, A. Nucci, A. Lauri, A. Bizzotto, F.R. De Filippo, C. Marmo, Maria Elena Riccioni, F. Esposito, L. Amitrano, C. Tomba, D. Conte, L.G. Cavallaro, B. Germanà, A. Anderloni, S. Metrangolo, A. Merighi, E. Buscarini, R. Pumpo, R.M. Zagari, Marco Soncini, Riccardo Marmo, R. De Franchis, A. Zambelli, F. Bazzoli, M. Parravicini, L. Ferraris, L. Purita, P. Borgheresi, L.M. Montalbano, S. Bargiggia, L. Furio, P. Gasparini, Annalisa Tortora, M. Franceschi, Alessandra Dell'Era, G. Napolitano, and G. Rotondano

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, General surgery, Gastroenterology, medicine, Upper gastrointestinal bleeding, medicine.disease, business
Published
2017
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14. P.10.1: Transfusion Strategy and Death Risk in Patients with Acute Non-Variceal Upper Gastro Intestinal Bleeding (NV-UGIB) in Italy: A Prospective Multicenter Observational Study

Author

A. Balzano, R. Bennato, M. Manno, S. Mangiafico, C. De Fanis, F. Esposito, F. De Nigris, R. De Franchis, A. Zambelli, F. Bazzoli, V. Boarino, Annalisa Tortora, A. Nucci, M. Franceschi, R. Lamanda, A. Bizzotto, F.R. De Filippo, S. Segato, C. Marmo, A. Andriulli, P. Cesaro, E. Buscarini, F. Zingone, A. Chirico, L. Amitrano, S. Mastrangelo, P. Borgheresi, L.M. Montalbano, L.G. Cavallaro, E. Di Giulio, O. Triossi, S. Bargiggia, A. Merighi, F. Parente, C. Londoni, M. De Matthaeis, G. D'Amico, R. Lauri, F. Cipolletta, P. Gasparini, G. Imperiali, Guido Costamagna, P. Di Giorgio, A. Repici, A. Paterlini, A. Anderloni, R.M. Zagari, Cristina Bucci, A. Russo, L. Ferraris, M.A. Bianco, R. Pumpo, G. Baldassarre, G. Bresci, D. Conte, L. Cipolletta, R. Conigliaro, B. Germanà, Marco Soncini, Riccardo Marmo, L. Orsini, Maria Elena Riccioni, Alessandra Dell'Era, G. Napolitano, L. Furio, M. Parravicini, L. Purita, and G. Spinzi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Death risk, Emergency medicine, Gastroenterology, medicine, In patient, Observational study, Gastro intestinal bleeding, Intensive care medicine, business
Published
2017
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17. P.15.9 TRANSFUSION STRATEGY AND DEATH RISK IN PATIENTS WITH ACUTE NON VARICEAL UPPER GASTRO INTESTINAL BLEEDING (NV-UGIB) IN ITALY: A PROSPECTIVE MULTICENTER OBSERVATIONAL STUDY

Author

R. Marmo, M. Soncini, L. Cipolletta, F. Parente, A. Paterlini, R. Bennato, F. Cipolletta, L. Orsini, S. Bargiggia, P. Cesaro, A. Bizzotto, A. Dell'Era, B. Germanà, L.G. Cavallaro, M.E. Riccioni, C. Marmo, A. Tortora, S. Segato, M. Parravicini, L. Purita, A. Chirico, G. Spinzi, G. Imperiali, A. Maringhi, V. Boarino, G. Bresci, S. Metrangolo, C. Bucci, G. Baldassarre, M. Franceschi, A. Nucci, F. De Nigris, E. Masci, R. Marin, S. Antoniazzi, L. Ferraris, A. Repici, A. Andreloni, M.A. Bianco, G. Rotondano, M. De Matthaeis, A. Lauri, C. De Fanis, P. Borgheresi, S. De Stefano, R. Lamanda, L. Furio, A. Russo, P. Di Giorgio, F. Politi, R. Pumpo, O. Triossi, G. Coccia, L.M. Montalbano, R.M. Zagari, A. Balzano, E. Buscarini, D. Conte, G. D'Amico, E. Di Giulio, P. Gasparini, and R. De Franchis

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Death risk, Gastroenterology, medicine, Observational study, In patient, Gastro intestinal bleeding, business
Published
2016
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18. Non-invasive tests in gastric diseases

Author

L.G. Cavallaro and F. Di Mario

Subjects
Gastritis, Atrophic, medicine.medical_specialty, Pathology, Atrophic gastritis, Stomach Diseases, Gastroenterology, Diagnosis, Differential, Atrophy, Stomach Neoplasms, Internal medicine, Gastrins, medicine, Gastric mucosa, CagA, Humans, Evidence-Based Medicine, Hepatology, Pepsinogens, business.industry, digestive, oral, and skin physiology, Interleukin-8, Intestinal metaplasia, Cancer, medicine.disease, digestive system diseases, Ghrelin, medicine.anatomical_structure, Gastric Mucosa, Cytokines, Gastritis, medicine.symptom, business, Gastric Neoplasm, Biomarkers
Abstract

Although the gastric cancer incidence is decreasing, this neoplasia remains one of the major causes of oncological mortality. Because of an insidious development, gastric cancer is often diagnosed in an advanced stage and consequently with a poor prognosis. Accurate non-invasive tests should be extremely useful in order to detect gastric neoplasm in an early phase. In clinical practice, there is no reliable bio-marker for detecting this malignant disease. However, intestinal as well as diffuse types of gastric cancer are preceded by gastric mucosa inflammation. Furthermore, the intestinal type of the neoplasia is, generally, related to chronic atrophic gastritis, especially if associated with intestinal metaplasia. In particular, the risk of the neoplasm is linked to both extension and severity of gastric atrophy. Serological parameters such as serum pepsinogens I (PGI) and II (PGII), gastrin-17 (G-17) cytokines (e.g. IL-8), antiparietal cells, IgG anti-Hp and CagA antibodies and lastly ghrelin supply information about either atrophic or inflammatory conditions characterising gastric mucosa. Low PGI and PGI/PGII ratio levels, especially if combined with high G-17 levels, are recognised bio-markers of corpus atrophic gastritis. Low G-17 levels could be, also, suggestive of antral atrophic gastritis. Furthermore, plasmatic ghrelin levels seem to be also a bio-marker of corpus atrophy. Anti-Hp IgG and CagA antibodies as well as PGII levels are able to detect gastric inflammation. Serological parameters could select subjects at risk for gastric mucosa alterations such as inflammation or atrophy, rather than gastric cancer itself. This review analyses the information derived from serological bio-markers as well as the involved clinical studies.

Published
2008

19. Are there useful biomarkers for gastric cancer?

Author

Angelo Franzè, L.G. Cavallaro, Giulia Martina Cavestro, F. Di Mario, Di Mario, F, Cavallaro, Lg, Cavestro, GIULIA MARTINA, and Franzé, A.

Subjects
medicine.medical_specialty, Atrophic gastritis, Autoimmune Gastritis, Population, Chronic gastritis, Gastroenterology, Helicobacter Infections, Stomach Neoplasms, Internal medicine, Pepsinogen A, Gastric mucosa, Medicine, Humans, education, Autoantibodies, education.field_of_study, Hepatology, business.industry, Stomach, Cancer, medicine.disease, digestive system diseases, medicine.anatomical_structure, Gastritis, medicine.symptom, business, Biomarkers
Abstract

In spite of a remarkable decrease of gastric cancer incidence [1], the neoplasia of the stomach represents the second most frequent cause of cancer mortality in the world [2], mainly, because of a late diagnosis. In the management of malignant gastric diseases, the challenge consists in selecting the high-risk population for which strategies could be developed for gastric cancer prevention. For this purpose, it is important to know both the histopathological sequence and aetio-pathogenetic mechanisms underlying gastric cancer. Both diffuse and intestinal gastric cancer arise in the setting of chronic inflammation and are strongly associated with Helicobacter pylori infection as shown in recent studies A minimal quantity of pepsinogen back-flows into the circulation. Both serological pepsinogen levels increase with H. pylori chronic inflammation, although PGII seems to be more reliable marker of gastric inflammation than PGI [7–9]. In the presence of severe corpus atrophic gastritis, significantly reduced serological PGI levels are observed. This condition is indirectly confirmed by increased gastrin17 levels (which is almost totally produced in the antrum) due to the negative antrum/corpus feed-back [10,11]. H. pylori infection is the major cause of chronic gastritis, peptic ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer. Specific antibodies against [3]. Thus, the evaluation of gastric inflammation is, indeed, quite important from the perspective of cancer prevention or screening. The gold standard to the diagnosis of chronic gastritis is based on histology. However, tissue from gastric biopsy could not reflect the whole gastric mucosa, though the conventional 4–5 samples. Furthermore, inter-observer discrepancies between pathologists could be present also applying the validated and diffused Updated Sydney System Classification [4]. Recently, different biomarkers were applied and/or validated in order to detect subjects or dyspeptic the bacterium are easily detected in the serum. Otherwise, H. pylori may also induce antibodies that react with gastric mucosa [12]. This infection is sometimes associated with the occurrence of parietal cell auto-antibodies (APCA). These auto-antibodies, namely, against and -subunits of protonic pump, are typically associated with autoimmune gastritis (the so-called type A gastritis). Furthermore, they can also develop in H. pylori positive patients due to a molecular mimicry between human Lewis antigens expressed on gastric mucosa and H. pylori lipopolysaccha

Published
2006

20. Efficacy of mesalazine in the treatment of symptomatic diverticular disease

Author

F. Di Mario, G. Comparato, Veronica Iori, G. Nervi, C. Carloni, Giovanni Aragona, M. Maino, S. Liatopoulou, Angelo Franzè, L.G. Cavallaro, L. Fanigliulo, A. Gnocchi, and Giulia Martina Cavestro

Subjects
Adult, Male, medicine.medical_specialty, Physiology, Nausea, Administration, Oral, Diverticulum, Colon, Gastroenterology, Risk Assessment, Severity of Illness Index, Drug Administration Schedule, Rifaximin, Statistics, Nonparametric, Diverticulitis, Colonic, chemistry.chemical_compound, Bloating, Mesalazine, Internal medicine, medicine, Dysuria, Humans, Single-Blind Method, Prospective Studies, Intestinal Mucosa, Mesalamine, Antibacterial agent, Aged, Probability, Aged, 80 and over, Analysis of Variance, Hepatology, Dose-Response Relationship, Drug, business.industry, Diverticulitis, Middle Aged, medicine.disease, Rifamycins, Treatment Outcome, chemistry, Anesthesia, Diverticular disease, Female, medicine.symptom, business, Follow-Up Studies
Abstract

We aimed to improve symptoms by means of mesalazine in symptomatic colonic diverticular disease patients. One hundred seventy outpatients (98 M, 72 F; age, 67.1 years; range, 39–84 years) were assigned to four different schedules: rifaximin, 200 mg bid (Group R1: 39 pts), rifaximin, 400 mg bid (Group R2: 43 pts), mesalazine, 400 mg bid (Group M1: 40 pts), and mesalazine, 800 mg bid (Group M2: 48 pts), for 10 days per month. At baseline and after 3 months we recorded 11 clinical variables (upper/lower abdominal pain/discomfort, bloating, tenesmus, diarrhea, abdominal tenderness, fever, general illness, nausea, emesis, dysuria), scored from 0 = no symptoms to 3 = severe. The global symptomatic score was the sum of all symptom scores. After 3 months in all schedules but Group R1, 3 of the 11 symptoms improved (P < 0.03); the global score decreased in all groups but Group R1 (P < 0.0001). Mesalazine-treated patients had the lowest global score at 3 months (P < 0.001). Mesalazine is as effective as rifaximin (higher dosage schedule) for diminishing some symptoms, but it appears to be better than rifaximin for improving the global score in those patients.

Published
2005

21. PA.28 SERUM PEPSINOGEN I AS NON INVASIVE MARKER OF GASTRIC ACID SECRETION

Author

R. Merli, A. Iori, Angelo Franzè, Carmelo Scarpignato, A. Cirillo, F. Di Mario, A. Bertelè, L.G. Cavallaro, E. Morana, Andrea Pilotto, Loredana Guida, J. Franzè, Marilisa Franceschi, Massimo Rugge, and M. Curlo

Subjects
Gastric chief cell, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Non invasive, Gastroenterology, Medicine, Gastric acid, Secretion, Serum pepsinogen, business
Published
2008
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22. PA.6 GASTRIN-17 (G-17): A SEROLOGICAL BIO-MARKER FOR DIAGNOSIS OF GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD)

Author

Angelo Franzè, R. Merli, E. Morana, J. Franzè, L.G. Cavallaro, M. Curlo, Loredana Guida, Raffaella Alessia Zuppardo, Iva Pelosini, F. Di Mario, A. Iori, A. Cirillo, Giulia Martina Cavestro, Carmelo Scarpignato, and A. Maini

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, GERD, Medicine, Gastro-esophageal reflux disease, business, medicine.disease, Gastrin, Serology
Published
2008
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24. P.26 DIAGNOSTIC ACCURACY OF SERUM PEPSINOGENS AND GASTRIN IN THE FOLLOW-UP OF HELICOBACTER PYLORI INFECTION: A PILOT STUDY

Author

Giulia Martina Cavestro, Carmelo Scarpignato, Peraldo Mario, Angelo Franzè, Luigi Gatta, Massimo Rugge, L.G. Cavallaro, Dolores Vaira, and F. Di Mario

Subjects
Helicobacter pylori infection, medicine.medical_specialty, Hepatology, medicine.drug_class, business.industry, Antibiotics, Gastroenterology, Diagnostic accuracy, Metronidazole, Levofloxacin, Clarithromycin, Internal medicine, medicine, Serum pepsinogen, business, medicine.drug, Gastrin
Abstract

ture was available for the 92% of the infected patients. Resistance to: M was found in 61% of the strains, C in 47.1% of the strains, and L in 18.3% of the strains. Double resistance to: C+M was found in 36.5% of the strains; C+L in 11.3% of the strains; and M+L in 14.7%. 10.2% of the strains were resistant to M+C+L. Considering resistance to a single antibiotic, resistance to M was more frequent in women (p

Published
2010
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25. P.10 'GASTROPANEL TEST' IN THE CLINICAL OUTCOME OF GERD: PROSPECTIVE SIX MONTHS CLINICAL STUDY

Author

F. Di Mario, Vincenzo Savarino, P. Perazzo, Dolores Vaira, L.G. Cavallaro, Angelo Franzè, Simone Bertolini, Massimo Rugge, Giulia Martina Cavestro, Carmelo Scarpignato, Luigi Gatta, Loredana Guida, and E. Morana

Subjects
Clinical study, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, GERD, business, medicine.disease, Test (assessment)
Abstract

“GASTROPANEL TEST” IN THE CLINICAL OUTCOME OF GERD: PROSPECTIVE SIX MONTHS CLINICAL STUDY L. Guida∗ ,1, P. Perazzo1 , S. Bertolini 1 , E. Morana1, D. Vaira2, C. Scarpignato1 , V. Savarino3 , L. Gatta1, L. Cavallaro4 , G. Cavestro1, M. Rugge3, A. Franze5, F. Di Mario1 1Universita di Parma, Parma; 2Universita di Bologna, Bologna; 3Universita di Padova, Padova; 4Ospedale di Belluno, Belluno; 5Ospedale Maggiore di Parma, Parma

Published
2010
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26. 'GASTROPANEL TEST' IN THE CLINICAL OUTCOME OF GERD

Author

Giulia Martina Cavestro, A. Iori, Vincenzo Savarino, Angelo Franzè, L.G. Cavallaro, Massimo Rugge, M. Curlo, F. Di Mario, E. Morana, and Loredana Guida

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, GERD, business, medicine.disease, Outcome (game theory), Test (assessment)
Published
2009
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27. INFLUENCE OF BMI ON GASTRIC ACID SECRETION IN ACID RELATED DISEASE

Author

Vincenzo Savarino, M. Caputo, Angelo Franzè, F. De Caro, Andrea Pilotto, Loredana Guida, A. Ianniello, E. Morana, N. Dal Bò, M. Curlo, L.G. Cavallaro, and F. Di Mario

Subjects
medicine.medical_specialty, Endocrinology, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Gastric acid, Secretion, Disease, business
Published
2009
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28. OC1.09.3 USEFULNESS OF GASTROPANEL FOR SCREENING OF ATROPHIC GASTRITIS IN PATIENTS WITH AUTOIMMUNE THYROID DISEASES

Author

E. Morana, L.G. Cavallaro, Cesare Bordi, Giulia Martina Cavestro, A. Bertelè, F. Di Mario, Roberta Minelli, Loredana Guida, A. Maini, Angelo Franzè, A. Iori, R. Merli, Antonio Nouvenne, and M. Curlo

Subjects
medicine.medical_specialty, medicine.anatomical_structure, Hepatology, business.industry, Atrophic gastritis, Internal medicine, Thyroid, Gastroenterology, medicine, In patient, business, medicine.disease
Published
2008
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29. OC3.07.1 CURCUMIN VS DOMPERIDON IN FUNCTIONAL DYSPEPSIA: BETTER THE PROKINETIC OR AN AGONIST OF VANILLOID RECEPTOR?

Author

M. Curlo, Mario Martelli, Antonio Nouvenne, Angelo Franzè, L.G. Cavallaro, A. Iori, Giulia Martina Cavestro, Carmelo Scarpignato, A. Maini, E. Morana, R. Merli, F. Di Mario, Iva Pelosini, Laura Martelli, and Loredana Guida

Subjects
Agonist, chemistry.chemical_compound, Domperidon, Hepatology, chemistry, medicine.drug_class, business.industry, Gastroenterology, medicine, Curcumin, Pharmacology, Receptor, business
Published
2008
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30. CS1.1 EFFICACY OF MESALAMINE AND THE ASSOCIATION OF MESALAMINE AND PROBIOTICS VERSUS RIFAXIMIN IN THE TREATMENT OF SYMPTOMATIC DIVERTICULAR DISEASE

Author

Paolo Bacchin, L.G. Cavallaro, Nadia Altavilla, R. Marin, F. Fedrizzi, L. Fanigliulo, M. Curlo, G. Tafner, Giovanni Aragona, N. Dal Bò, G. Comparato, V. Marcon, R. De Bastiani, Angelo Franzè, and F. Di Mario

Subjects
medicine.medical_specialty, chemistry.chemical_compound, Hepatology, chemistry, business.industry, Internal medicine, Gastroenterology, medicine, Diverticular disease, business, Rifaximin
Published
2008
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32. PA.77 FACTORS PREDICTING SURVIVAL IN HEPATOCELLULAR CARCINOMA: MONOCENTRIC ANALYSIS OF 402 PATIENTS IN NORTH ITALY

Author

M. Di Stasi, P. Tansini, L.G. Cavallaro, Fabio Fornari, G. Marinone, G. Comparato, Giovanni Aragona, F. Giangregorio, G. Sbolli, L. Fanigliulo, and G. Leandro

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Hepatocellular carcinoma, Gastroenterology, medicine, medicine.disease, business
Published
2008
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33. PA.7 CLINICAL VARIABILITY IN THE PRESENTATION OF THE GASTROESOPHAGEAL REFLUX DISEASE BEFORE THE HP ERA (STUDY FROM 1975 TO 1995)

Author

A. Iori, J. Franzè, Marilisa Franceschi, N. Stefani, Massimo Rugge, L.G. Cavallaro, M. Curlo, F. Di Mario, A. Maini, Andrea Pilotto, N. Dal Bò, Giulia Martina Cavestro, E. Morana, Angelo Franzè, and Loredana Guida

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Reflux, Medicine, Disease, Presentation (obstetrics), business
Published
2008
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35. MCP1 GENOTYPE IN ACUTE PANCREATITIS

Author

Mario Sianesi, Giulia Martina Cavestro, Angelo Franzè, A. Protti, S. Okolicsanyi, Luca Frulloni, Simone Bertolini, L.G. Cavallaro, Giuliana Sereni, G. Cavallini, P. Zanelli, Elena Masselli, F. Di Mario, and P. Del Rio

Subjects
medicine.medical_specialty, Endocrinology, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, Genotype, Internal Medicine, medicine, Acute pancreatitis, medicine.disease, business, Gastroenterology
Published
2006
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37. Gastro panel® for detection of atrophic gastritis: The 'Parma model'

Author

A. Bertelè, Angelo Franzè, Giancarlo Colla, M. Maino, S. Liatopoulou, F. Marencci, Veronica Iori, P. Muzzetto, F. Di Mario, E. Morana, Giulia Martina Cavestro, L.G. Cavallaro, G. Nervi, A. Gnocchi, V. Corrente, and R. Merli

Subjects
medicine.medical_specialty, Hepatology, Atrophic gastritis, business.industry, Gastro, Internal medicine, Gastroenterology, medicine, medicine.disease, business
Published
2006
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38. Quality of life in uncomplicated diverticular disease: Is it another good reason for the treatment?

Author

Angelo Franzè, Giovanni Aragona, F. Di Mario, Veronica Iori, S. Liatopoulou, L. Fanigliulo, P. Muzzetto, Giulia Martina Cavestro, G. Nervi, G. Comparato, L.G. Cavallaro, C. Carloni, and M. Maino

Subjects
medicine.medical_specialty, Quality of life (healthcare), Hepatology, business.industry, General surgery, Gastroenterology, Medicine, Uncomplicated diverticular disease, business, Surgery
Published
2006
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39. Gastrin-17 (G-17) as a sensitive serological bio-marker for diagnosis of gastro-esophageal reflux disease (GERD) independently of H. pylori status

Author

Giulia Martina Cavestro, A. Maini, Angelo Franzè, Mario Plebani, Veronica Iori, G. Nervi, R. Merli, M. Maino, L.G. Cavallaro, Antonio Nouvenne, L. Faniglinlo, F. Di Mario, and Daniela Basso

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, GERD, Medicine, Gastro-esophageal reflux disease, business, medicine.disease, Serology, Gastrin
Published
2006
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41. A new curcumin-based one week therapy for eradication of H. pylori infection

Author

Mario Martelli, G. Nervi, Angelo Franzè, Giulia Martina Cavestro, Veronica Iori, N. Dal Bò, L.G. Cavallaro, N. Stefani, M. Maino, F. Di Mario, and Laura Martelli

Subjects
chemistry.chemical_compound, medicine.medical_specialty, Hepatology, chemistry, business.industry, Internal medicine, Gastroenterology, Curcumin, medicine, business, H pylori infection
Published
2006
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42. Clinical presentation of 324 patients with hepatocellular carcinoma (HCC) in a single center of North Italy

Author

Fabio Fornari, Angelo Franzè, G. Sbolli, M. Di Stasi, L.G. Cavallaro, Giovanni Aragona, M.G. Marinone, F. Giangregorio, and F. Di Mario

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Hepatocellular carcinoma, Gastroenterology, medicine, Presentation (obstetrics), Single Center, business, medicine.disease
Published
2006
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45. A prospective therapeutical one-year study with Pantoprazole for patients with oropharingeal picture of GERD

Author

L.G. Cavallaro, A. Pioltto, C. Guatti-Zuliant, G. Leandro, Giulia Martina Cavestro, Giuseppe Battaglia, B. Gemarnà, N. Dal Bò, G. Mastropaolo, Marilisa Franceschi, and F. Di Mario

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, GERD, medicine, medicine.disease, business, Pantoprazole, medicine.drug
Published
2001
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