1. Brain MR Imaging of Patients with Perinatal Chikungunya Virus Infection
- Author
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F.C.P. de Almeida Di Maio Ferreira, Diogo Goulart Corrêa, Maria Elisabeth Lopes Moreira, J.M. de Andrade Lopes, F.P.P.L. Lopes, L.C.H. da Cruz, F.C. Rueda-Lopes, Heron Werner, and T. A. L. Freddi
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Encephalopathy ,Neuroimaging ,medicine.disease_cause ,Pediatrics ,Virus ,030218 nuclear medicine & medical imaging ,White matter ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Pregnancy ,Rotavirus ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Chikungunya ,biology ,Transmission (medicine) ,business.industry ,Infant, Newborn ,Brain ,medicine.disease ,biology.organism_classification ,Magnetic Resonance Imaging ,Infectious Disease Transmission, Vertical ,medicine.anatomical_structure ,Parechovirus ,Chikungunya Fever ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Since 2005, it has been known that mother-to-child transmission of the chikungunya virus is possible. Transmission generally occurs in the perinatal period. In the present study, we describe the brain lesions seen on MR imaging of 6 cases of perinatal chikungunya infection. Patients who underwent brain MR imaging in the acute phase presented with areas of restricted diffusion in the white matter, suggesting a perivascular distribution, whereas those in the subacute/late phase showed cystic lesions, also with a perivascular distribution, with or without brain atrophy. One patient also presented with scattered hemorrhages in the frontal and parietal lobes. Important differential diagnoses include rotavirus, Parechovirus, herpes simplex infection, and hypoxic-ischemic encephalopathy, depending on the disease phase.
- Published
- 2019
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