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Context. Accreting planetary-mass objects have been detected at H α, but targeted searches have mainly resulted in non-detections. Accretion tracers in the planetary-mass regime could originate from the shock itself, making them particularly susceptible to extinction by the accreting material. High-resolution (R > 50 000) spectrographs operating at H α should soon enable one to study how the incoming material shapes the line profile. Aims. We calculate how much the gas and dust accreting onto a planet reduce the H α flux from the shock at the planetary surface and how they affect the line shape. We also study the absorption-modified relationship between the H α luminosity and accretion rate. Methods. We computed the high-resolution radiative transfer of the H α line using a one-dimensional velocity–density–temperature structure for the inflowing matter in three representative accretion geometries: spherical symmetry, polar inflow, and magnetospheric accretion. For each, we explored the wide relevant ranges of the accretion rate and planet mass. We used detailed gas opacities and carefully estimated possible dust opacities. Results. At accretion rates of Ṁ ≲ 3 × 10−6 MJ yr−1, gas extinction is negligible for spherical or polar inflow and at most AH α ≲ 0.5 mag for magnetospheric accretion. Up to Ṁ ≈ 3 × 10−4 MJ yr−1, the gas contributes AH α ≲ 4 mag. This contribution decreases with mass. We estimate realistic dust opacities at H α to be κ ~ 0.01–10 cm2 g−1, which is 10–104 times lower than in the interstellar medium. Extinction flattens the LH α –Ṁ relationship, which becomes non-monotonic with a maximum luminosity LH α ~ 10−4 L⊙ towards Ṁ ≈ 10−4 MJ yr−1 for a planet mass ~10 MJ. In magnetospheric accretion, the gas can introduce features in the line profile, while the velocity gradient smears them out in other geometries. Conclusions. For a wide part of parameter space, extinction by the accreting matter should be negligible, simplifying the interpretation of observations, especially for planets in gaps. At high Ṁ, strong absorption reduces the H α flux, and some measurements can be interpreted as two Ṁ values. Highly resolved line profiles (R ~ 105) can provide (complex) constraints on the thermal and dynamical structure of the accretion flow., Astronomy & Astrophysics, 657, ISSN:0004-6361, ISSN:1432-0746

The processes regulating protoplanetary disk evolution are constrained by studying how mass accretion rates scale with stellar and disk properties. The spread in these relations can be used as a constraint to the models of disk evolution, but only if the impact of accretion variability is correctly accounted for. While the effect of variability might be substantial in the embedded phases of star formation, it is often considered limited at later stages. Here we report on the observed large variation in the accretion rate for one target, XX Cha, and we discuss the impact on population studies of classical T Tauri stars. The mass accretion rate determined by fitting the UV-to-near-infrared spectrum in recent X-Shooter observations is compared with the one measured with the same instrument 11 years before. XX Cha displays an accretion variability of almost 2 dex between 2010 and 2021. Although the timescales on which this variability happens are uncertain, XX Cha displays an extreme accretion variability for a classical T Tauri star. If such behavior is common among classical T Tauri stars, possibly on longer timescales than previously probed, it could be relevant for discussing the disk evolution models constrained by the observed spread in accretion rates. Finally, we remark that previous studies of accretion variability based on spectral lines may have underestimated the variability of some targets., Accepted for publication in A&A letters

The evolution of young stars and disks is driven by the interplay of several processes, notably accretion and ejection of material. Critical to correctly describe the conditions of planet formation, these processes are best probed spectroscopically. About five-hundred orbits of the Hubble Space Telescope (HST) are being devoted in 2020-2022 to the ULLYSES public survey of about 70 low-mass (M, Comment: Accepted for publication on Astronomy & Astrophysics. 15 pages + appendix, language edited version

We present results of our study of the close pre-main sequence spectroscopic binary CVSO 104 in Ori OB1, based on data obtained within the PENELLOPE legacy program. We derive, for the first time, the orbital elements of the system and the stellar parameters of the two components. The system is composed of two early M-type stars and has an orbital period of about 5 days and a mass ratio of 0.92, but contrarily to expectations does not appear to have a tertiary companion. Both components have been (quasi-)synchronized, but the orbit is still very eccentric. The spectral energy distribution clearly displays a significant infrared excess compatible with a circumbinary disk. The analysis of HeI and Balmer line profiles, after the removal of the composite photospheric spectrum, reveals that both components are accreting at a similar level. We also observe excess emission in H$\alpha$ and H$\beta$, which appears redshifted or blueshifted by more than 100 km/s with respect to the mass center of the system depending on the orbital phase. This additional emission could be connected with accretion structures, such as funnels of matter from the circumbinary disk. We also analyze the optical companion located at about 2".4 from the spectroscopic binary. This companion, that we named CVSO 104B, turns out to be a background Sun-like star not physically associated with the PMS system and not belonging to Ori OB1., Comment: Accepted for publication in Astronomy and Astrophysics; 16 pages, 18 figures

Context. NGC 2264 is a young cluster whose accretion properties can be investigated in detail by taking advantage of the FLAMES data in the context of the Gaia-ESO Survey. In fact, the analysis of the Hα emission line profile can provide us with information about the accretion and ejection activity of young stars. However, a strong nebular emission that contributes to the Hα emission can alter the profiles, with consequences for their physical interpretation. Aims. Our study is aimed at investigating the accretion and ejection properties of NGC 2264 by applying a proper treatment of the sky contribution to the Hα and forbidden emission lines (FELs; [SII] and [NII] doublets). Methods. We developed a tool, the OHαNA-method, to handle the strong nebular contribution and spectra with spurious profiles of the Hα and FELs, namely altered Hα profiles or absorption features artificially created where emission lines (FELs) are expected. We derived the quantitative measurements of relevant parameters to describe the accretion and ejection processes in young members of NGC 2264, focusing on reliable quantities derived from the width of the lines, which is relatively unaffected by the nebular emission, unlike the intensity peak, which can be altered significantly. Results. We derive the quantitative measurements related to the Hα emission line and discuss the comparison between the original and sky-subtracted spectra. We thus reveal possible profile alterations with consequences for their physical interpretation. Furthermore, we show the analysis of the variability for multi-epoch observations, also deriving the velocity of the infalling and outflowing plasma from the wings of the broad Hα emission line (in accreting stars). We also explore the mass accretion rate versus full width at zero intensity of the Hα line, namely Ṁ versus FWZI(Hα), a correlation based on the width of the emission line, which is expected to be more robust with respect to any measurement derived from the peak (e.g., Hα10%) and possibly altered by the nebular contribution. Conclusions. We are able to ascertain that more than 20% of the confirmed accretors, which have already been identified in NGC 2264, are affected by the alteration of their line profiles due to the contribution of the nebular emission. Therefore, this is an important issue to consider when investigating accretion and ejection processes in young stellar clusters. While a small fraction of spectra can be unequivocally classified as either unaffected by nebular emission or dominated by nebular emission, the majority (> 90%) represent intermediate cases whose spectral features have to be investigated in detail to derive reliable measurements of the relevant parameters and their physical implications.

We report on the discovery of periodic dips in the multiband lightcurve of ISO-ChaI 52, a young stellar object in the Chamaeleon I dark cloud. This is one among the peculiar objects that display very low or negligible accretion both in their UV continuum and spectral lines, although they present a remarkable infrared excess emission characteristic of optically-thick circumstellar disks. We have analyzed a VLT/X-Shooter spectrum with the tool ROTFIT to determine the stellar parameters. The latter, along with photometry from our campaign with the REM telescope and from the literature, have allowed us to model the spectral energy distribution and to estimate the size and temperature of the inner and outer disk. From the rotational period of the star/disk system of 3.45 days we estimate a disk inclination of 36$^\circ$. The depth of the dips in different bands has been used to gain information about the occulting material. A single extinction law is not able to fit the observed behavior, while a two-component model of a disk warp composed of a dense region with a gray extinction and an upper layer with an ISM-type extinction provides a better fit of the data., 11 pages, 11 figures; accepted for publication in Astronomy & Astrophysics

We investigate ongoing accretion activity in young stars in the TW Hydrae association (TWA, ~8-10 Myr), an ideal target to probe the final stages of disk accretion down to brown dwarf masses. Our sample comprises eleven TWA members with infrared excess, amounting to 85% of the total TWA population with disks, with spectral types between M0 and M9, and masses between 0.58 and 0.02 Msol. We employed homogeneous spectroscopic data from 300 to 2500 nm, obtained with X-shooter, to derive individual extinction, stellar parameters, and accretion parameters simultaneously. We then examined Balmer lines and forbidden emission lines to probe the physics of the star-disk interaction environment. We detected signatures of ongoing accretion for 70% of our TWA targets. This implies a fraction of accretors of 13-17% across the entire TWA (accounting for potentially accreting members not included in our survey). The spectral emission associated with these stars reveals a more evolved stage of these accretors compared to younger PMS populations: (i) a large fraction (~50%) exhibit nearly symmetric, narrow H_alpha line profiles; (ii) over 80% exhibit Balmer decrements consistent with moderate accretion and optically thin emission; (iii) less than a third exhibit forbidden line emission in [O I] 6300A, indicative of winds and outflows activity. However, the distribution in accretion rates (Mdot) derived for the TWA sample follows closely that of younger regions for Mstar~0.1-0.3 Msun. An overall correlation between Mdot and Mstar is detected, best reproduced by Mdot~Mstar^(2.1+/-0.5). At least in the lowest Mstar regimes, stars that still retain a disk at ages ~8-10 Myr are found to exhibit statistically similar, albeit moderate, accretion levels as those measured around younger objects. This slow Mdot evolution may be associated with longer evolutionary timescales of disks around low-mass stars., 27 pages (19 in the main text plus Appendices), 7 tables, 19 figures. Accepted for publication in Astronomy & Astrophysics. Abstract shortened for the arXiv listing

We aim to test a purely photometric approach to statistically identify a young clustered population embedded in a large population of field stars, with no prior knowledge on the nature of stars in the field. We conducted our blind test study on the NGC 2264 region, which hosts a well-known young cluster. We selected a large (4 sq. deg.) area around the NGC 2264 cluster, and assembled an extensive r,i,J catalog of the field from pre-existing large-scale surveys. We then mapped the stellar color locus on the (i-J, r-i) diagram to select M-type stars, which: i) comprise a significant fraction of the Galactic stellar population; ii) exhibit the strongest luminosity evolution from the PMS to the MS; iii) have r,i,J color properties that provide a direct and empirical estimate of A_V. A comparative analysis of the photometric and spatial properties of M-type stars as a function of A_V enabled us to probe the structure and stellar content of our field. We could identify two distinct populations: a diffuse field population and a clustered population. The presence of occulting material, spatially associated with the clustered population, allowed us to derive an estimate of its distance (800-900 pc) and age (~0.5-5 Myr), consistent with the literature parameters for the NGC 2264 star-forming region. The extracted clustered population exhibits a hierarchical structure, in excellent agreement with the NGC 2264 subregions reported in the literature. Our selection of clustered members is coherent with the literature census of the NGC 2264 cluster for about 95% of the objects in the inner regions of the field, where the contamination rate by field stars in our sample is only 2%. The method tested here can be readily applied to surveys like Pan-STARRS and the future LSST to undertake a first complete census of low-mass, young star populations down to distances of several kpc across the Galactic plane., 19 pages, 22 figures; accepted for publication in Astronomy & Astrophysics; abstract shortened for the ArXiv listing

Pre-main sequence stars are variable sources. In diskless stars this variability is mainly due to the rotational modulation of dark photospheric spots and active regions, as in main sequence stars even if associated with a stronger magnetic activity. Aims. We aim at analyzing the simultaneous optical and X-ray variability in these stars to unveil how the activity in the photosphere is connected with that in the corona, to identify the dominant surface magnetic activity, and to correlate our results with stellar properties, such as rotation and mass. Methods. We analyzed the simultaneous optical and X-ray variability in stars without inner disks (e.g., class III objects and stars with transition disks) in NGC 2264 from observations obtained with Chandra/ACIS-I and CoRoT as part of the Coordinated Synoptic Investigation of NGC 2264. We searched for those stars whose optical and X-ray variability is correlated, anti-correlated, or not correlated by sampling their optical and X-ray light curves in suitable time intervals and studying the correlation between the flux observed in optical and in X-rays. We then studied how this classification is related with stellar properties. Results. Starting from a sample of 74 class III/transition disk (TD) stars observed with CoRoT and detected with Chandra with more than 60 counts, we selected 16 stars whose optical and X-ray variability is anti-correlated, 11 correlated, and 17 where there is no correlation. The remaining stars did not fall in any of these groups. We interpreted the anti-correlated optical and X-ray variability as typical of spot-dominated sources, due to the rotational modulation of photospheric spots spatially coincident to coronal active regions, and correlated variability typical of faculae-dominated sources, where the brightening due to faculae is dominant over the darkening due to spots. [Conclusions not shown in the pre-print], Comment: Accepted for publication on Astronomy & Astrophysics. Appendices are not included in this preprint

Most stars born in clusters and recent results suggest that star formation (SF) preferentially occurs in subclusters. Studying the morphology and SF history of young clusters is crucial to understanding early SF. We identify the embedded clusters of young stellar objects (YSOs) down to M stars, in the HII regions RCW33, RCW32 and RCW27 of the Vela Molecular Ridge. Our aim is to characterise their properties, such as morphology and extent of the clusters in the three HII regions, derive stellar ages and the connection of the SF history with the environment. Through public photometric surveys such as Gaia, VPHAS, 2MASS and Spitzer/GLIMPSE, we identify YSOs with IR, Halpha and UV excesses, as signature of circumstellar disks and accretion. In addition, we implement a method to distinguish M dwarfs and giants, by comparing the reddening derived in several optical/IR color-color diagrams, assuming suitable theoretical models. Since this diagnostic is sensitive to stellar gravity, the procedure allows us to identify pre-main sequence stars. We find a large population of YSOs showing signatures of circumstellar disks with or without accretion. In addition, with the new technique of M-type star selection, we find a rich population of young M stars with a spatial distribution strongly correlated to the more massive population. We find evidence of three young clusters, with different morphology. In addition, we identify field stars falling in the same region, by securely classifying them as giants and foreground MS stars. We identify the embedded population of YSOs, down to about 0.1 Msun, associated with the HII regions RCW33, RCW32 and RCW27 and the clusters Vela T2, Cr197 and Vela T1, respectively, showing very different morphologies. Our results suggest a decreasing SF rate in Vela T2 and triggered SF in Cr197 and Vela T1., Comment: Accepted for publication in A&A; 20 pages, 22 figures, 6 tables

Pre-main sequence stars are variable sources. In stars with disks, this variability is related to the morphology of the inner circumstellar region (, Accepted for publication by Astronomy & Astrophysics

Background: The main consequences of neurogenic bladder dysfunction are renal damage related to high intravesical pressure, vesicoureteral reflux (VUR) and urinary tract infections (UTIs). Neurologic impairment, UTIs and VUR are known to be linked with a potential for renal scarring. Of paramount importance as predisposing conditions for UTIs in neurogenic bladder are poor bladder drainage and detrusor-sphincter dyssynergy which cause further abnormalities on the internal bladder surface and, consequently, a bladder wall rich in glycosaminoglycans (GAGs). Materials and Methods: The aim of this study is to investigate the correlation between GAG excretion and bladder wall degeneration in 43 patients affected by spina bifida (SB) and 40 healthy age-matched control children. Results: The amounts of GAGs excreted vary greatly in SB patients aged from 0 to 5 years, and values are comparable to those observed in normal controls. They are significantly higher in children over 5 years of age. Conclusion: The increased excretion of GAGs in older SB patients is an important parameter in the evaluation of the physiopathological condition of the bladder wall and hence may be considered a possible marker for monitoring the beginning of bladder damage.

This paper evaluates the performance of an optical packet switching architecture that uses the wavelength conversion technique to solve the packet contention problem. The architecture, referred to as shared per node (SPN), is equipped with limited-range wavelength converters shared per node. We evaluate for this architecture the performance of the optimum scheduling algorithm by resolving an integer linear programming problem. Unfortunately the optimum scheduling algorithm has a high time complexity and it cannot be adopted for optical packet switches requiring packet scheduling time in the order of 10/100 ns. For this reason we propose some scheduling algorithms allowing the best optimum scheduling performance to be reached in low computation time. In particular an algorithm, based on heuristic rules, is proposed able to reach good performance with a complexity O(M),M being the number of wavelengths used

Hyperprolactinemia is one of the causes of sterility. Cabergoline is indicated in cases resistant to bromocriptine, but, usually, its administration is interrupted at the beginning of the pregnancy. A case of prolonged treatment with cabergoline during pregnancy is reported, without teratogenic effects on the fetus.

The pathogenic mechanism of neural tube defects may involve genetic polymorphisms and nutritional factors related to homocysteine metabolism. We evaluated the association of polymorphisms of three genes affecting vitamin B12-dependent remethylation of homocysteine, transcobalamin (TC), methionine synthase (MTR) and MTR reductase (MTRR), combined or not with methylenetetrahydrofolate reductase (MTHFR), with the risk of having neural tube defect in 40 children with spina bifida and 58 matched controls from South Italy. MTR 2756 AG/GG, TC 777 CG/GG /MTHFR 677 CC and MTRR 66 GG /MTHFR 677 CC genotypes increased the risk with odds ratios of 2.6 (P=0.046), 2.4 (P=0.028) and 4.5 (P=0.023), respectively. In contrast, MTHFR 677 TT was protective (odds ratio=0.11, P=0.009). In conclusion, genetic determinants affecting the cellular availability or MTRR-dependent reduction of B12 may increase the risk of spina bifida.

A preliminary open study showed that intranasal immunotherapy can be administered with a constant dosage scheduling, with good safety and efficacy. In the present study the efficacy of constant dosage intranasal immunotherapy has been evaluated on 43 grass-allergic rhinitis patients according to a double-blind placebo-controlled design. The product employed for the study had a formulation in powder, and was administrated by a nasal insufflator. Clinical efficacy was evaluated for each symptom, taking into consideration the severity of the symptom in relation to its frequency. Sneezing, rhinorrea, nasal blockage, eyes itching, and drug consumption were significantly improved in active-treated patients compared to placebo-treated. The safety of this treatment was good, the only adverse events observed being some local and mild symptoms. This immunotherapy was well-tolerated and easy to handle by the patients by self-administration.

The pathophysiological events regarding the atherosclerotic processes are present already in early childhood. Various clinical trials confirm tight correlation between dyslipidemia and cardiac and cerebrovascular complications. Over the clinical dyslipidemia genetically determined, various systemic diseases can lead to anomalies of the lipidic metabolism. The determination and analysis of the lipidic pattern is essential during childhood and in particular in patients with renal disease for the increased risk of progressive failure of renal function and for the central role of kidney in lipidic homeostasis. Cardiovascular event is the most important cause of mortality in patients with end-stage renal disease. In children with nephrotic syndrome, renal failure, hemodialysis or after renal transplantation, an increase of the serum values of triglycerides, cholesterol, LDL, VLDL is generally observed. The presence of anomalies in lipidic pattern must be considered during the course of renal disease for preventing the progression of renal damage. Thus, the pharmacological therapy and diet permit to prevent the atherosclerotic events.