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Aim of review. To analyze the options of application of Lactobacillus reuteri DSMZ17648 (Pylopass™) within Helicobacter pylori eradication. Summary. H. pylori eradication therapy is considered as one of the optional spheres for clinical application of probiotic medications. According to available data certain strains of probiotics are effective in decreasing of gastrointestinal adverse effects rates, associated with eradication therapy while the other can potentiate the efficacy of H. pylori eradication itself. L. reuteri strain DSM17648 which was chosen from over 700 wildtype strains of Lactobacillus spp. possess the ability for selective adhesion to H. pylori in vivo in the gastric media. DSM17648 strain of L. reuteri form coaggregates with various H. pylori strains and serotypes both in vivo and in vitro. It was revealed that lyophilizate of this strain (PylopassTM) blocks adhesion of H. pylori to epithelial cells as well. Clinical trials demonstrate the effect of PylopassTMon gastric mucosa colonization by H. pylori according to the 13C urea breath test data and as well the increase in H. pylori eradication rate when the productis added the to triple therapy modes. Conclusion. Potential of PylopassTM combination to various H. pylori eradication therapy modes is a subject offutnet multicenter randomized clinical trials for assessment of optimal combination to antibiotic drugs, treatment duration and adverse effect rates. The value of monotherapy by this metabiotic at chronic H. pyloriassociated gastritis is a subject of further studies.

This study presents an analysis of the content of handwritten records from Muslim metric books of the mid-19th century at the Komarovskaya Yurt Mosque in Tobolsk Province. The analysis focuses on the second part, which includes information on marriages and divorces. Building upon previous research analyzing birth data from the first part of mosque records, this work introduces, for the first time, data on marriages and divorces of residents of Western Siberia belonging to a single ethnic group: the mosque’s parishioners were Bukharans — migrants from Central Asia. A total of 116 marriage records and six divorce records were analyzed. The statistics suggest that the institution of marriage was stable. The study reveals the ages of those getting married, marriage conditions, dowry amounts paid, reasons for divorce, and polygamy practices. It is proven that despite the lack of surnames among the Tatar population in the 19th century, recording the names of marrying individuals, their fathers, witnesses, and social status in mosque records allows for the identification of each individual. Interfaith marriage contacts were not recorded during the analyzed period. The relevance of this research lies in providing new insights into Muslim marriage customs and social processes in a specific territory during the specified period.