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Several planetary formation models have been proposed to explain the observed abundance and variety of compositions of super-Earths and mini-Neptunes. In this context, multitransiting systems orbiting low-mass stars whose planets are close to the radius valley are benchmark systems, which help to elucidate which formation model dominates. We report the discovery, validation, and initial characterization of one such system, TOI-2096, composed of a super-Earth and a mini-Neptune hosted by a mid-type M dwarf located 48 pc away. We first characterized the host star by combining different methods. Then, we derived the planetary properties by modeling the photometric data from TESS and ground-based facilities. We used archival data, high-resolution imaging, and statistical validation to support our planetary interpretation. We found that TOI-2096 corresponds to a dwarf star of spectral type M4. It harbors a super-Earth (R$\sim1.2 R_{\oplus}$) and a mini-Neptune (R$\sim1.90 R_{\oplus}$) in likely slightly eccentric orbits with orbital periods of 3.12 d and 6.39 d, respectively. These orbital periods are close to the first-order 2:1 mean-motion resonance (MMR), which may lead to measurable transit timing variations (TTVs). We computed the expected TTVs amplitude for each planet and found that they might be measurable with high-precision photometry delivering mid-transit times with accuracies of $\lesssim$2 min. Moreover, measuring the planetary masses via radial velocities (RVs) is also possible. Lastly, we found that these planets are among the best in their class to conduct atmospheric studies using the James Webb Space Telescope (JWST). The properties of this system make it a suitable candidate for further studies, particularly for mass determination using RVs and/or TTVs, decreasing the scarcity of systems that can be used to test planetary formation models around low-mass stars., 25 pages, 21 figures. Aceptted for publication in Astronomy & Astrophysics

The CARMENES instrument was conceived to deliver high-accuracy radial velocity (RV) measurements with long-term stability to search for temperate rocky planets around a sample of nearby cool stars. The broad wavelength coverage was designed to provide a range of stellar activity indicators to assess the nature of potential RV signals and to provide valuable spectral information to help characterise the stellar targets. The CARMENES Data Release 1 (DR1) makes public all observations obtained during the CARMENES guaranteed time observations, which ran from 2016 to 2020 and collected 19,633 spectra for a sample of 362 targets. The CARMENES survey target selection was aimed at minimising biases, and about 70% of all known M dwarfs within 10 pc and accessible from Calar Alto were included. The data were pipeline-processed, and high-level data products, including 18,642 precise RVs for 345 targets, were derived. Time series data of spectroscopic activity indicators were also obtained. We discuss the characteristics of the CARMENES data, the statistical properties of the stellar sample, and the spectroscopic measurements. We show examples of the use of CARMENES data and provide a contextual view of the exoplanet population revealed by the survey, including 33 new planets, 17 re-analysed planets, and 26 confirmed planets from transiting candidate follow-up. A subsample of 238 targets was used to derive updated planet occurrence rates, yielding an overall average of 1.44+/-0.20 planets with 1 M_Earth < M sin i < 1000 M_Earth and 1 d < P_orb < 1000 d per star, and indicating that nearly every M dwarf hosts at least one planet. CARMENES data have proven very useful for identifying and measuring planetary companions as well as for additional applications, such as the determination of stellar properties, the characterisation of stellar activity, and the study of exoplanet atmospheres., Published in A&A (https://www.aanda.org/10.1051/0004-6361/202244879), 25 pages, 12 figures, Tables 1 and 2 only available online

Precise measurements of stellar parameters are required in order to develop our theoretical understanding of stellar structure. These measurements enable errors and uncertainties to be quantified in theoretical models and constrain the physical interpretation of observed phenomena, such as the inflated radii of low-mass stars. We use newly-available TESS light curves combined with published radial velocity measurements to improve the characterization of 12 low mass eclipsing binaries composed of an M~dwarf accompanied by a brighter F/G star. We present and analyse ground-based simultaneous four-colour photometry for two targets. Our results include the first measurements of the fundamental properties of two of the systems. Light curve and radial velocity information were converted into the physical parameters of each component of the systems using an isochrone fitting method. We also derive the effective temperatures of the M~dwarfs, almost tripling the number of such measurements. The results are discussed in the context of radius inflation. We find that exquisite precision in the age estimation of young objects is required to determine their inflation status. However, all but three of the objects are securely located among the main sequence, demonstrating radius inflation and the necessity to develop our understanding of the complex physical processes governing the evolution of low-mass stars. We investigated the hypothesis that luminosity is unaffected by the inflation problem but the findings were not conclusive., Comment: 16 pages, 7 figures

For more than two years, we monitored with the HARPS-N spectrograph the 400 Myr-old star HD\,63433, which hosts two close-in (orbital periods $P_b\sim7.1$ and $P_c\sim20.5$ days) sub-Neptunes detected by the TESS space telescope, and it was announced in 2020. Using radial velocities and additional TESS photometry, we aim to provide the first measurement of their masses, improve the measure of their size and orbital parameters, and study the evolution of the atmospheric mass-loss rate due to photoevaporation. We tested state-of-the-art analysis techniques and different models to mitigate the dominant signals due to stellar activity that are detected in the radial velocity time series. We used a hydro-based analytical description of the atmospheric mass-loss rate, coupled with a core-envelope model and stellar evolutionary tracks, to study the past and future evolution of the planetary masses and radii. We derived new measurements of the planetary orbital periods and radii ($P_b=7.10794\pm0.000009$ d, $r_b=2.02^{+0.06}_{-0.05}$ $R_{\oplus}$; $P_c=20.54379\pm0.00002$ d, $r_c=2.44\pm0.07$ $R_{\oplus}$), and determined mass upper limits ($m_b\lesssim$11 $M_{\oplus}$; $m_c\lesssim$31 $M_{\oplus}$; 95$\%$ confidence level), with evidence at a 2.1--2.7$\sigma$ significance level that HD\,63433\,c might be a dense mini-Neptune with a Neptune-like mass. For a grid of test masses below our derived dynamical upper limits, we found that HD\,63433\,b has very likely lost any gaseous H-He envelope, supporting HST-based observations that are indicative of there being no ongoing atmospheric evaporation. HD\,63433\,c will keep evaporating over the next $\sim$5 Gyr if its current mass is $m_c\lesssim$15 $M_{\oplus}$, while it should be hydrodynamically stable for higher masses., Comment: 22 pages, accepted for publication on Astronomy & Astrophysics

Introduction: Health care providers face a multitude of challenges in providing care to patients with diabetes who are experiencing homelessness. Considering the unique circumstance faced by this population, mainstream services must be adapted and tailored to meet patients’ needs. The objective of this study was to explore both the barriers faced by providers and programs in offering comprehensive diabetes care to these patients, and their suggested areas for improvement. Methods: We conducted semi-structured interviews with providers who care for patients who have diabetes and/or who experience homelessness. Participants included primary care providers, specialist physicians, dietitians, shelter staff, outreach workers, and diabetes educators in five Canadian centres (n=96). Responses were analyzed using qualitative thematic analysis. Results: Barriers most frequently cited by providers were a lack of resources for staff. Other challenges included policy barriers (restrictions on billing codes, care professionals’ scope of practice, and the structure of financial support for this population), duplication of services, and alternative priorities of care. Participants identified several strategies to improve care, which targeted the following spheres: location of service provision and coordination of care, policy changes, and extending funding and resources for staff, such as augmented funding to hire allied health professionals in outpatient settings and increasing outreach capabilities. Conclusion: Programs that strive to address the unique needs of clients experiencing homelessness face numerous challenges. Unique potential solutions to these barriers, such as service provision in a convenient location involving social and health services, incorporating allied health care providers in care to a greater extent, and updating policies to reflect the social complexity of the population can improve diabetes care.

We present broad-band photometry of 30 planetary transits of the ultra-hot Jupiter KELT-16b, using five medium-class telescopes. The transits were monitored through standard B, V, R, I filters and four were simultaneously observed from different places, for a total of 36 new light curves. We used these new photometric data and those from the TESS space telescope to review the main physical properties of the KELT-16 planetary system. Our results agree with previous measurements but are more precise. We estimated the mid-transit times for each of these transits and combined them with others from the literature to obtain 69 epochs, with a time baseline extending over more than four years, and searched for transit time variations. We found no evidence for a period change, suggesting a lower limit for orbital decay at 8 Myr, with a lower limit on the reduced tidal quality factor of $Q^{\prime}_{\star}>(1.9 \pm 0.8) \times 10^5$ with $95\%$ confidence. We built up an observational, low-resolution transmission spectrum of the planet, finding evidence of the presence of optical absorbers, although with a low significance. Using TESS data, we reconstructed the phase curve finding that KELT-16b has a phase offset of $25.25 \pm 14.03$ $^{\circ}$E, a day- and night-side brightness temperature of $3190 \pm 61$ K and $2668 \pm 56$ K, respectively. Finally, we compared the flux ratio of the planet over its star at the TESS and Spitzer wavelengths with theoretical emission spectra, finding evidence of a temperature inversion in the planet's atmosphere, the chemical composition of which is preferably oxygen-rich rather than carbon-rich., 17 pages, 16 figures, Accepted for publication in Monthly Notices of the Royal Astronomical Society

OBJECTIVE To investigate the feasibility and pharmacokinetics of cytarabine delivery as a subcutaneous continuous-rate infusion with the Omnipod system. ANIMALS 6 client-owned dogs diagnosed with meningoencephalomyelitis of unknown etiology were enrolled through the North Carolina State University Veterinary Hospital. PROCEDURES Cytarabine was delivered at a rate of 50 mg/m2/hour as an SC continuous-rate infusion over 8 hours using the Omnipod system. Plasma samples were collected at 0, 4, 6, 8, 10, 12, and 14 hours after initiation of the infusion. Plasma cytarabine concentrations were measured by high-pressure liquid chromatography. A nonlinear mixed-effects approach generated population pharmacokinetic parameter estimates. RESULTS The mean peak plasma concentration (Cmax) was 7,510 ng/mL (range, 5,040 to 9,690 ng/mL; SD, 1,912.41 ng/mL), average time to Cmax was 7 hours (range, 4 to 8 hours; SD, 1.67 hours), terminal half-life was 1.13 hours (SD, 0.29 hour), and the mean area under the curve was 52,996.82 hours X μg/mL (range, 35,963.67 to 71,848.37 hours X μg/mL; SD, 12,960.90 hours X μg/mL). Cmax concentrations for all dogs were more than 1,000 ng/mL (1.0 μg/mL) at the 4-, 6-, 8-, and 10-hour time points. CLINICAL RELEVANCE An SC continuous-rate infusion of cytarabine via the Omnipod system is feasible in dogs and was able to achieve a steady-state concentration of more than 1 μg/mL 4 to 10 hours postinitiation of cytarabine and a Cmax of 7,510 ng/mL (range, 5,040 to 9,690 ng/mL; SD, 1,912.41 ng/mL). These are comparable to values reported previously with IV continuous-rate infusion administration in healthy research Beagles and dogs with meningoencephalomyelitis of unknown etiology.

Aim: We aim to refine the orbital and physical parameters and determine the sky-projected planet orbital obliquity of five eccentric transiting planetary systems: HAT-P-15, HAT-P-17, HAT-P-21, HAT-P-26, and HAT-P-29. Each of the systems hosts a hot Jupiter, except for HAT-P-26 which hosts a Neptune-mass planet. Methods: We observed transit events of these planets with the HARPS-N spectrograph, obtaining high-precision radial velocity measurements that allow us to measure the Rossiter-McLaughlin effect for each of the target systems. We used these new HARPS-N spectra and archival data, including those from Gaia, to better characterise the stellar atmospheric parameters. The photometric parameters for four of the hot Jupiters were recalculated using 17 new transit light curves, obtained with an array of medium-class telescopes, and data from the TESS space telescope. HATNet time-series photometric data were checked for the signatures of rotation periods of the target stars and their spin axis inclination. Results: From the analysis of the Rossiter-McLaughlin effect, we derived a sky-projected obliquity of 13, -26.3, -0.7, -26 degree for HAT-P-15b, HAT-P-17b, HAT-P-21b and HAT-P-29b, respectively. Due to the quality of the data, we were not able to well constrain the sky-projected obliquity for HAT-P-26b, although a prograde orbit is favoured. The stellar activity of HAT-P-21 indicates a rotation period of 15.88 days, which allowed us to determine its true misalignment angle (25 degree). Our new analysis of the physical parameters of the five exoplanetary systems returned values compatible with those existing in the literature. Using TESS and the available transit light curves, we reviewed the orbital ephemeris for the five systems and confirmed that the HAT-P-26 system shows transit timing variations, which may tentatively be attributed to the presence of a third body., 31 pages, 16 figures, Accepted for publication in Astronomy & Astrophysics

Soccer is becoming an increasingly popular sport amongst women. Common movements during play, such as jumping and cutting, require rapid acceleration and deceleration of multiple lower-limb joints. The anterior cruciate ligament (ACL), which contributes to stabilization of the knee, is often injured during these events. ACL injury typically requires costly surgery, extended time away from sports, and jeopardizes long-term joint health. Due to sex-specific factors such as menstruation and anatomical disadvantages, women are more susceptible to tearing their ACL. Injury often occurs in non-contact scenarios during rapid acceleration or deceleration movements. Research has examined these movements and established several kinematic and kinetic mechanisms as well as muscle activation patterns that frequently occur at the time of injury, however results tend to vary based on population. This article summarizes recent and relevant literature of ACL injury mechanisms and highlights the lack of specific research in the high-risk female soccer athlete population. Due to inconclusive risk factors, injury prevention programs within this population have been inconsistent. ACL injury risk for female soccer athletes should be closer examined so that more specific injury risks can be established, and effective protective measures can be taken. Raised awareness of this need may capture attention in the research and medical communities and potentially stimulate the development of strategies that limit future ACL injury and thus the challenges it brings to the high-risk female soccer athlete.

Scope. The aim of the study was to evaluate how the Covid–19 state of emergency affected the activity of the Syncope Unit (SU). During the lockdown, the outpatient activities of the SU were suspended(1). Materials. From March 2020 to March 2021, approximately 95 patients booked for the Tilt–up test were medically evaluated by teleconsultation and televiewer. Vasovagal syncope (VVS) (61%), orthostatic hypotension (OH) (5%) was diagnosed. The patients were trained, through television and video tutorials, in the use of counter pressure maneuvers (PCM) and tilt training, while dietary indications were provided and the importance of adequate oral hydration and the need to take, as recommended by the guidelines, 2–3l of water per day. We retrospectively observed the result at the end of the lockdown period: patients with VVS and OH called by the SU no longer needed to perform tilt up tests because they had obtained a significant reduction in syncope in 90% of cases. Discussion Reflex syncope is the most frequent, representing 21% of all types of syncope (2). Accurate history and physical examination are necessary for the diagnosis, sometimes a guided path in the SU in the unexplained forms. The indicated therapy is non–pharmacological (increase the salt and water content in the diet, avoid triggers, tilt training)(2) and, especially in young people, has been shown to prevent recurrences(2). Back pressure maneuvers (PCM) are effective in preventing syncope(3); oral hydration increases blood volume and improves symptoms(4). Conclusions The Covid–19 state of emergency, through the use of telemedicine tools, has made it possible to reach the diagnosis of reflex syncope through an accurate anamnestic evaluation, has allowed patients to be reassured about the benignity of the events and has motivated patients to implement the recommended non–pharmacological therapies. This has made it possible to reduce the number of tilt tests to be performed when the SU reopens.

Background A careful and integrated follow up after hospitalization for heart failure (HF) may represent a feasible strategy to optimize the adherence to ESC guidelines and reduce the occurrence of adverse events (mortality, re–hospitalizations). Methods A strict integration between hospital and local health district proximity office cardiologist through an integrated clinical data sharing software has been implemented in Apulia region, Italy, in order to optimize the management of the HF patient after an hospitalization: the PONTE (PDTA FOR INTEGRATED FOLLOW–UP TERRITORY HOSPITAL OF THE PATIENT WITH CARDIAC HEART FAILURE) (bridge) project. As until December 2021, 1200 patients with HF have been enrolled in the project, both with reduced (HFrEF) and preserved ejection fraction (HFpEF). Adherence to ESC HF guidelines in HFrEF patients before vs after December 2020 was compared. Results In the HFrEF population (56%) the mean age was 63 years, 38% were hypertensive, 15% diabetic, 40% had ischemic heart disease, 42% were previously treated with coronary angioplasty, 56% had an ICD/CRT, 22% had atrial fibrillation. Mean NYHA class was 2.2, mean LVEF 30%, mean NT–proBNP values 4027 pg/mL, mean serum creatinine 1 mg/dL, 91% were taking beta–blockers (BB), 86% mineral corticoid receptor antagonists (MRA), 98% ACE–inhibitors/angiotensin–receptor–antagonists/neprilysin and angiotensin receptor antagonists (ACE/ARB/ARNI), and 13% ARNI. Compared to patients enrolled before 2020, ARNI prescription increased in 2021 (60% vs 13%, p Conclusions The implementation the PONTE project shows an improved adherence to ESC HF guidelines.

Background Patients discharged after acute coronary syndrome (ACS) deserve a tight follow–up in order to optimize long–term pharmacological treatments and prevent the occurrence of adverse events. The aim of the PONTE–ACS Project was to evaluate the impact of a dedicated cooperative program between hospital and outpatient structures on the persistance on recommended therapies and long–term outcome occurrence in patients discharged after ACS. Materials and Methods This was a prospective, longitudina, cohort study. We enrolled patients who were discharged after ACS and/or after coronary revascularization in the HUB centres of ASL Bari. Patients underwent cardiologic evaluation and laboratory examination at 30 days, 3–, 6–, and 12–months from the index event. The following endpoint were considered: all–cause mortality, ACS recurrence/cardiac ischemia/angina, restenosis/intrastent thrombosis, stroke/transient ischemic attack (TIA), heart failure, any bleeding. Adherence and persistence to therapies were evalauted as well as the percentage of patients who reached the recommended goals. Results We enrolled 2476 patients (77.4% male, mean age: 67.2±12.0 yrs). After one–year follow–up, 99.5% (p Conclusions The PONTE–ACS Project was able to improve the management of patients after ACS, to manage a structured follow–up protocol for patients discharged after ACS and/or coronary revascularization, thus improving adhesion to recommended therapies and keeping lower the incidence of major cardiovascular and bleeding events.

Background Heart rate is able to impact on the prognosis if patients with cardiovascular diseases. The aim of this study was to evaluate the impact of heart rate at discharge of patients with ACS and/or coronary revascularization on long–term follow–up Methods This was a subanalysis of the PONTE ACS study. The PONTE ACS study is a prospective, longitudinal, cohort study which enrolled patients who were discharged from HUB centres of ASL BARI after coronary revascularization and/or ACS. They underwent clinical evaluation at 30 days, 3, 6 and 1 year–follow–up. The data were collected after including the data in the electronic medical record of the PONTE ACS study. Anthropometric, clinical and pharmacological parameters, instrumental and laboratory examinations were included. Data were computed in order to evaluate the major determinants of all–cause mortality at one–year follow–up. Results We finally enrolled 2476 patients (77.4% male, mean age: 67.2±12.0 years). Pharmacological treatments were optimized during the follow–up visits. Heart rate at discharge was 65.5 ± 11.3 bpm. At univariate regression analysis, age, systolic and diastolic arterial pressure, body mass index, smoke habit, diabetes, hypertension, high–density lipoprotein and total cholesterol, creatinine, haemoglobin, fasting glycemia, left ventricle ejection fraction, heart rate, use of ACEi/sartans, statins, dual/triple anti–thrombotics were all related to all–cause mortality. Nevertheless, at multivariate Cox regression analysis, age (β coefficient: 0.07117 ± 0.01942, p = 0.0002), history of hypertension (1.4823 ± 0.7476, p = 0.0474), and heart rate (0.04409 ± 0.01278, p = 0.0006) remained related to the primary endpoint. Conclusions Heart rate confirmed to act as a long–term predictor of all–cause death in patients with ACS.

We report the discovery and characterization of the transiting extrasolar planet TOI-1710$\:$b. It was first identified as a promising candidate by the Transiting Exoplanet Survey Satellite (TESS). Its planetary nature was then established with SOPHIE and HARPS-N spectroscopic observations via the radial-velocity method. The stellar parameters for the host star are derived from the spectra and a joint Markov chain Monte-Carlo (MCMC) adjustment of the spectral energy distribution and evolutionary tracks of TOI-1710. A joint MCMC analysis of the TESS light curve and the radial-velocity evolution allows us to determine the planetary system properties. From our analysis, TOI-1710$\:$b is found to be a massive warm super-Neptune ($M_{\rm p}=28.3\:\pm\:4.7\:{\rm M}_{\rm Earth}$ and $R_{\rm p}=5.34\:\pm\:0.11\:{\rm R}_{\rm Earth}$) orbiting a G5V dwarf star ($T_{\rm eff}=5665\pm~55\mathrm{K}$) on a nearly circular 24.3-day orbit ($e=0.16\:\pm\:0.08$). The orbital period of this planet is close to the estimated rotation period of its host star $P_{\rm rot}=22.5\pm2.0~\mathrm{days}$ and it has a low Keplerian semi-amplitude $K=6.4\pm1.0~\mathrm{m\:s^{-1}}$; we thus performed additional analyses to show the robustness of the retrieved planetary parameters. With a low bulk density of $1.03\pm0.23~\mathrm{g\:cm^{-3}}$ and orbiting a bright host star ($J=8.3$, $V=9.6$), TOI-1710$\:$b is one of the best targets in this mass-radius range (near the Neptunian desert) for atmospheric characterization via transmission spectroscopy, a key measurement in constraining planet formation and evolutionary models of sub-Jovian planets., 18 pages, 16 figures, 5 tables, A&A in press

The COVID-19 pandemic created delays in surgical care. The population with obesity has a high risk of death from COVID-19. Prior literature shows the most effective way to combat obesity is by weight loss surgery. At different times throughout the COVID-19 pandemic, elective inpatient surgeries have been halted due to bed availability. Recognizing that major complications following bariatric surgery are extremely low (bleeding 0-4%, anastomotic leaks 0.8%), we felt outpatient bariatric surgery would be safe for low-risk patients. Complications such as DVT, PE, infection, and anastomotic leaks typically present after 7 days postoperatively, well outside the usual length of stay. Bleeding events, severe postoperative nausea, and dehydration typically occur in the first few days postoperatively. We designed a pathway focused on detecting and preventing these early post-op complications to allow safe outpatient bariatric surgery.We used a preoperative evaluation tool to risk stratify bariatric patients. During a 16-month period, 89 patients were identified as low risk for outpatient surgery. We designed a postoperative protocol that included IV hydration and PO intake goals to meet a safe discharge. We sent patients home with a pulse oximeter and had them self-monitor their pulse and oxygen saturation. We called all patients at 10 pm for a postoperative assessment and report of their vitals. Patients returned to clinic the following day and were seen by a provider, received IV hydration, and labs were drawn.80 of 89 patients (89.8%) were successfully discharged on POD 0. 3 patients were readmitted within 30 days. We had zero deaths in our study cohort and no morbidity that would have been prevented with postoperative admission.We demonstrate that by identifying low-risk patients for outpatient bariatric surgery and by implementing remote monitoring of vitals early outpatient follow-up, we were able to safely perform outpatient bariatric surgery.

We study the transit timings of 10 exoplanets in order to investigate potential transit timing variations in them. We model their available ground-based light curves, some presented here and others taken from the literature, and homogeneously measure the mid-transit times. We statistically compare our results with published values and find that the measurement errors agree. However, in terms of recovering the possible frequencies, homogeneous sets can be found to be more useful, of which no statistically relevant example has been found for the planets in our study. We corrected the ephemeris information of all 10 planets we studied and provide these most precise light elements as references for future transit observations with space-borne and ground-based instruments. We found no evidence for secular or periodic changes in the orbital periods of the planets in our sample, including the ultra-short period WASP-103 b, whose orbit is expected to decay on an observable time-scale. Therefore, we derive the lower limits for the reduced tidal quality factors (Q$^{\prime }_{\star }$) for the host stars based on best-fitting quadratic functions to their timing data. We also present a global model of all available data for WASP-74 b, which has a Gaia parallax-based distance value ∼25 per cent larger than the published value.

Funding: LM acknowledges support from the University of Rome Tor Vergata through ‘Mission: Sustainability 2017’ fund. ChH and GH gratefully acknowledge the support of the European Research Council (ERC) Starting Grant no. 257431. We present the results of 14 nights of I-band photometric monitoring ofthe nearby brown dwarf binary, ɛ Indi Ba,Bb. Observations were acquired over 2 months, and total close to 42 hours of coverage at a typically high cadence of 1.4 minutes. At a separation of just 0.7″, we do not resolve the individual components, and so effectively treat the binary as if it were a single object. However, ɛ Indi Ba (spectral type T1) is the brightest known T-type brown dwarf, and is expected to dominate the photometric signal. We typically find no strong variability associated with the target during each individual night of observing, but see significant changes in mean brightness - by as much as 0.10 magnitudes - over the 2 months of the campaign. This strong variation is apparent on a timescale of at least 2 days. We detect no clear periodic signature, which suggests we may be observing the T1 brown dwarf almost pole-on, and the days-long variability in mean brightness is caused by changes in the large-scale structure of the cloud coverage. Dynamic clouds will very likely produce lightning, and complementary high cadence V-band and Hα images were acquired to search for the emission signatures associated with stochastic 'strikes'. We report no positive detections for the target in either of these passbands. Publisher PDF

Mitochondria exist in a complex network that is constantly remodeling via the processes of fission and fusion in response to intracellular conditions and extracellular stimuli. Excessive fragmentation of the mitochondrial network because of an imbalance between fission and fusion reduces the cells’ capacity to generate ATP and can be a forerunner to cell death. Given the critical roles mitochondria play in cellular homeostasis and innate immunity, it is not surprising that many microbial pathogens can disrupt mitochondrial activity. Here we note the putative contribution of mitochondrial dysfunction to gut disease and review data showing that infection with microbial pathogens can alter the balance between mitochondrial fragmentation and fusion, preventing normal remodeling (i.e., dynamics) and can lead to cell death. Current data indicate that infection of epithelia or macrophages with microbial pathogens will ultimately result in excessive fragmentation of the mitochondrial network. Concerted research efforts are required to elucidate fully the processes that regulate mitochondrial dynamics, the mechanisms by which microbes affect epithelial mitochondrial fission and/or fusion, and the implications of this for susceptibility to infectious disease. We speculate that the commensal microbiome of the gut may be important for normal epithelial mitochondrial form and function. Drugs designed to counteract the effect of microbial pathogen interference with mitochondrial dynamics may be a new approach to infectious disease at mucosal surfaces.

Background & Aims Mitochondria exist in a constantly remodelling network, and excessive fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric inflammation, but any contribution of altered mitochondrial dynamics (ie, fission/fusion) to gut inflammation is unknown. We hypothesized that perturbed mitochondrial dynamics would contribute to colitis. Methods Quantitative polymerase chain reaction for markers of mitochondrial fission and fusion was applied to tissue from dextran sodium sulfate (DSS)-treated mice. An inhibitor of mitochondrial fission, P110 (prevents dynamin related protein [Drp]-1 binding to mitochondrial fission 1 protein [Fis1]) was tested in the DSS and di-nitrobenzene sulfonic acid (DNBS) models of murine colitis, and the impact of DSS ± P110 on intestinal epithelial and macrophage mitochondria was assessed in vitro. Results Analysis of colonic tissue from mice with DSS-colitis revealed increased mRNA for molecules associated with mitochondrial fission (ie, Drp1, Fis1) and fusion (optic atrophy factor 1) and increased phospho-Drp1 compared with control. Systemic delivery of P110 in prophylactic or treatment regimens reduced the severity of DSS- or DNBS-colitis and the subsequent hyperalgesia in DNBS-mice. Application of DSS to epithelial cells or macrophages caused mitochondrial fragmentation. DSS-evoked perturbation of epithelial cell energetics and mitochondrial fragmentation, but not cell death, were ameliorated by in vitro co-treatment with P110. Conclusions We speculate that the anti-colitic effect of systemic delivery of the anti-fission drug, P110, works at least partially by maintaining enterocyte and macrophage mitochondrial networks. Perturbed mitochondrial dynamics can be a feature of intestinal inflammation, the suppression of which is a potential novel therapeutic direction in inflammatory bowel disease.

The hot Jupiter WASP-80b has been identified as a possible excellent target for detecting and measuring HeI absorption in the upper atmosphere. We observed 4 primary transits of WASP-80b in the optical and near-IR using the HARPS-N and GIANO-B high-resolution spectrographs, focusing on the HeI triplet. We further employed a three-dimensional hydrodynamic aeronomy model to understand the observational results. We did not find any signature of planetary absorption at the position of the HeI triplet with an upper limit of 0.7% (i.e. 1.11 planetary radii; 95% confidence level). We re-estimated the stellar high-energy emission that we combined with a stellar photospheric model to generate the input for the hydrodynamic modelling. We obtained that, assuming a solar He to H abundance ratio, HeI absorption should have been detected. Considering a stellar wind 25 times weaker than solar, we could reproduce the non-detection only assuming a He to H abundance ratio about 16 times smaller than solar. Instead, considering a stellar wind 10 times stronger than solar, we could reproduce the non-detection only with a He to H abundance ratio about 10 times smaller than solar. We attempted to understand this result by collecting all past HeI measurements looking for correlations with stellar high-energy emission and planetary gravity, but without finding any. WASP-80b is not the only planet with a sub-solar estimated He to H abundance ratio, suggesting the presence of efficient physical mechanisms (e.g. phase separation, magnetic fields) capable of significantly modifying the He to H content in the upper atmosphere of hot Jupiters. The planetary macroscopic properties and the shape of the stellar spectral energy distribution are not sufficient for predicting the presence or absence of detectable metastable He in a planetary atmosphere, as also the He abundance appears to play a major role., Comment: Accepted for publication on A&A

HATS-18b is a transiting planet with a large mass and a short orbital period, and is one of the best candidates for the detection of orbital decay induced by tidal effects. We present extensive photometry of HATS-18 from which we measure 27 times of mid-transit. Two further transit times were measured from data from the Transiting Exoplanet Survey Satellite (TESS) and three more taken from the literature. The transit timings were fitted with linear and quadratic ephemerides and an upper limit on orbital decay was determined. This corresponds to a lower limit on the modified stellar tidal quality factor of $Q_\star^{\,\prime} > 10^{5.11 \pm 0.04}$. This is at the cusp of constraining the presence of enhanced tidal dissipation due to internal gravity waves. We also refine the measured physical properties of the HATS-18 system, place upper limits on the masses of third bodies, and compare the relative performance of TESS and the 1.54-m Danish Telescope in measuring transit times for this system., Accepted for publication in MNRAS. 12 pages, 4 tables, 6 figures. This is the authors' version of the accepted paper

The field of exo-atmospheric characterisation is progressing at an extraordinary pace. Atmospheric observations are now available for tens of exoplanets, mainly hot and warm inflated gas giants, and new molecular species continue to be detected revealing a richer atmospheric composition than previously expected. Thanks to its warm equilibrium temperature (963$\pm$18~K) and low-density (0.219$\pm$0.031~g cm$^{-3}$), the close-in gas giant WASP-69b represents a golden target for atmospheric characterization. With the aim of searching for molecules in the atmosphere of WASP-69b and investigating its properties, we performed high-resolution transmission spectroscopy with the GIANO-B near-infrared spectrograph at the Telescopio Nazionale Galileo. We observed three transit events of WASP-69b. During a transit, the planetary lines are Doppler-shifted due to the large change in the planet's radial velocity, allowing us to separate the planetary signal from the quasi-stationary telluric and stellar spectrum. Considering the three nights together, we report the detection of CH$_4$, NH$_3$, CO, C$_2$H$_2$, and H$_2$O, at more than $3.3\sigma$ level. We did not identify the presence of HCN and CO$_2$ with confidence level higher than 3$\sigma$. This is the first time that five molecules are simultaneously detected in the atmosphere of a warm giant planet. These results suggest that the atmosphere of WASP-69b is possibly carbon-rich and characterised by the presence of disequilibrium chemistry., Comment: 10 pages, 5 figures. Accepted for publication in Astronomy & Astrophysics

Context. Exoplanetary properties strongly depend on stellar properties: to know the planet with accuracy and precision it is necessary to know the star as accurately and precisely as possible. Aims. Our immediate aim is to characterize in a homogeneous and accurate way a sample of 27 transiting planet-hosting stars observed within the Global Architecture of Planetary System program. For the wide visual binary XO-2, we considered both components (N: hosting a transiting planet; S: without a known transiting planet). Our final goal is to widely analyze the sample by deriving several stellar properties, abundances of many elements, kinematic parameters, and discuss them in the context of planetary formation. Methods. We determined the stellar parameters (effective temperature, surface gravity, rotational velocity) and abundances of 26 elements (Li, C, N, O, Na, Mg, Al, Si, S, Ca, Sc, Ti, V, Cr, Fe, Mn, Co, Ni, Cu, Zn, Y, Zr, Ba, La, Nd, Eu). Our study is based on high-resolution HARPS-N at TNG and FEROS at ESO spectra and uniform techniques. Depending on stellar parameters and chemical elements, we used line equivalent widths or spectral synthesis methods. We derived kinematic properties taking advantage of Gaia data and for the first time in exoplanet host stars we estimated ages using elemental ratios as chemical clocks. Results. The effective temperature of our stars is ~4400–6700 K, while the iron abundance [Fe/H] is within −0.3 and 0.4 dex. Lithium is present in seven stars. The [X/H] and [X/Fe] abundances versus [Fe/H] are consistent with the Galactic chemical evolution. The dependence of [X/Fe] with the condensation temperature is critically analyzed with respect to stellar and kinematic properties. All targets with measured C and O abundances show C/O < 0.8, compatible with Si present in rock-forming minerals. Mean C/O and [C/O] values are slightly lower than for the Sun. Most of targets show 1.0 < Mg/Si < 1.5, compatible with Mg distributed between olivine and pyroxene, and mean Mg/Si lower than for the Sun. HAT-P-26, the target hosting the lowest-mass planet, shows the highest Mg/Si ratio. From our chemodynamical analysis we find agreement between ages and position within the Galactic disk. Finally, we note a tendency for higher-density planets to be around metal-rich stars and hints of higher stellar abundances of some volatiles (e.g., O) for lower-mass planets. We cannot exclude that part of our results could be also related to the location of the stars within the Galactic disk. Conclusions. We try to trace the planetary migration scenario from the composition of the planets related to the chemical composition of the hosting stars. This kind of study will be useful for upcoming space mission data to get more insights into the formation-migration mechanisms.

Sequential digital dermoscopy (SDD) enables the diagnosis of a subgroup of slow-growing melanomas that lack suspicious features at baseline examination but exhibit detectable change on follow-up. The combined use of total-body photography and SDD is recommended in high-risk subjects by current guidelines. To establish the usefulness of SDD for low-risk individuals, we conducted a retrospective study using electronic medical records of low-risk patients with a histopathological diagnosis of cutaneous melanoma between 1 January 2016 and 31 December 2019, who had been referred and monitored for long-term follow-up of clinically suspicious melanocytic nevi. We sought to compare the distribution of “early” cutaneous melanoma, defined as melanoma in situ and pT1a melanoma, between SDD and periodical handheld dermoscopy in low-risk patients. A total of 621 melanomas were diagnosed in a four-year timespan; 471 melanomas were diagnosed by handheld dermoscopy and 150 by digital dermoscopy. Breslow tumor thickness was significantly higher for melanomas diagnosed by handheld compared to digital dermoscopy (0.56 ± 1.53 vs. 0.26 ± 0.84, p = 0.030, with a significantly different distribution of pT stages between the two dermoscopic techniques. However, no significant difference was found with respect to the distribution of pT stages, mean Breslow tumor thickness, ulceration, and prevalence of associated melanocytic nevus in tumors diagnosed on periodical handheld dermoscopy compared to SDD. Our results confirm that periodical dermoscopic examination enables the diagnosis of cutaneous melanoma at an earlier stage compared to first-time examination as this was associated in our patients with better prognostic features. However, in our long-term monitoring of low-risk subjects, Breslow tumor thickness and pT stage distribution did not differ between handheld periodical dermoscopy and SDD.

Intestinal homeostasis is highly dependent on optimal epithelial barrier function and permeability. Intestinal epithelial cells (IEC) regulate these properties acting as cellular gatekeepers by selectively absorbing nutrients and controlling the passage of luminal bacteria. These functions are energy demanding processes that are presumably met through mitochondrial-based processes. Routine methods for examining IEC mitochondrial function remain sparse, hence, our objective is to present standardized methods for quantifying mitochondrial energetics in an immortalized IEC line. Employing the murine IEC4.1 cell line, we present adapted methods and protocols to examine mitochondrial function using two well-known platforms: the Seahorse Extracellular Flux Analyzer and Oxygraph-2 k. To demonstrate the applicability of these protocols and instruments, IEC were treated with and without the murine colitogenic agent, dextran sulfate sodium (DSS, 2% w/v). Profound impairments with DSS treatment were found with both platforms, however, the Oxygraph-2 k allowed greater resolution of affected pathways including short-chain fatty acid metabolism. Mitochondrial functional analysis is a novel tool to explore the relationship between IEC energetics and functional consequences within the contexts of health and disease. The outlined methods offer an introductory starting point for such assessment and provide the investigator with insights into platform-specific capabilities.

O objetivo deste trabalho e apresentar um sistema para acompanhamento de investimentos realizados para aumentar a produtividade ou reducao de custos das lavouras de cana-de-acucar, assim como, nos processos produtivos para producao de etanol, com o intuito de proporcionar maior facilidade no acesso aos dados de desempenho desses investimentos, dando seguranca e transparencia aos usineiros e investidores e, assim, fortalecer a sustentabilidade do setor sucroenergetico.

Background: Cytarabine (CA) is used to treat dogs with meningoencephalitis of unknown etiology (MUE) by subcutaneous or intravenous administration. Aim: The objective was to investigate transdermal iontophoresis and rectal administration as alternative routes of CA delivery. Methods: Two client-owned dogs with MUE were studied. The ActivaPatch® IONTOGOTM 12.0 iontophoresis drug delivery system delivered 200 mg/m2 CA transdermally. Blood samples were collected by sparse sampling technique after initiation of the device. At another visit, 100 mg/m2 CA was administered rectally. Blood samples were collected by sparse sampling technique after administration. Plasma CA concentrations were measured by high-pressure liquid chromatography. Results: The concentration of plasma CA after transdermal and rectal administration was below the limits of quantification (0.1 μg/ml) in all samples suggesting inadequate bioavailability with transdermal and rectal administration. Conclusion: Transdermal and rectal CA administration are not reasonable alternative routes of delivery.

Very high cycle fatigue fracture is often associated with internal crack propagation and one major problem to study the initiation and the propagation of this internal crack is to detect its initiation and quantify its propagation rate. The objective of the present work is to develop an experimental methodology to follow the initiation and propagation of the internal crack. The experimental technique presented here is based on temperature field measurement on the specimen surface during an ultrasonic fatigue test using infrared thermography. Indeed, plasticity in the reverse cyclic plastic zone near the crack front generates heat sources due to the dissipation of plastic energy rate and thus an increase of the temperature which propagates through the specimen thanks to heat conduction. By considering the heat source located in the reverse cyclic plastic zone and the geometry of the crack obtained by tomographic observations, finite element simulation of the heat transfer problem enables us to establish a relationship between the internal crack growth and the temperature field evolution on the specimen surface. The results obtained for a cast aluminum alloy are presented and analyzed. ANR-16-CE08-0039

We present and analyze 58 transit light curves of TrES-3b and 98 transit light curves of Qatar-1b observed by Transiting Exoplanet Survey Satellite (TESS), plus two transit light curves of Qatar-1b observed by us using a ground-based 1.23\,m telescope. These light curves are combined with the best-quality light curves taken from the Exoplanet Transit Database (ETD) and literature. The precisely determined mid-transit times from these light curves enable us to obtain the refined orbital ephemerides with improved precision for both hot Jupiters. From the timing analysis, we find an indication for the presence of transit timing variations (TTVs) in both systems. Since the observed TTVs are unlikely to be short-term and periodic, the possibility of additional planets in the orbits close to TrES-3b and Qatar-1b are ruled out. Possible causes of long-term TTVs such as orbital decay, apsidal precession, the Applegate mechanism and line-of-sight acceleration are also examined. However, none of these possibilities are found to explain the observed TTV of TrES-3b. In contrast to this, the line-of-sight acceleration appears to be a plausible explanation for the observed TTV of Qatar-1b. In order to confirm these findings, further high-precision transit and RV observations of both systems would be worthwhile., Comment: 38 pages, 16 figures, 8 tables, accepted for publication in AJ