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2 results on '"L. Luski"'

1. Mucosal immunity: immune response (PP-066)

Author

N. Lycke, H. Kim, R. Vaicaitiene, M. Lee, J. Chang, H. Fukaya, K. Yamada, R. S. Gilbert, S. Kojima, L. M. Sollid, G. Seo, H. E. Steiner, S. Kimura, R. Chávez-Ramírez, H. Ohno, G. Duménil, Oliver Schulz, H. Okazawa, K. Tani, A. Givoni, P. N. T. Binh, D. Underhill, W. Agace, H. Tlaskalova-Hogenova, T. Kojima, M. Godínez-Victoria, Z. Xiang, P. Nilsson, E. Podack, E. L. Voronov, R. Kobayashi, R. Kvietkauskaite, V. Rivera-Aguilar, K. Soda, T. Kawara, R. Di Niro, N. Ohno, H. León-Chávez, M. T. Cantorna, F. Maruyama, M. Ebisawa, T. Nochi, P. Kim, G. S. Pontes, W. W. Agace, Y. Yoshikai, A. Shiokawa, S. Tsunoda, O. Liesenfeld, M. Yamamoto, T. Kamradt, A. A. Resendiz-Albor, T. Furuya, M. Ikutani, T. Saito, H. Tsutsui, H. Asanuma, T. Eguchi, A. Gómez-Anzures, Y. Yoshioka, I. Takahashi, L. Gram, S. Fukuda, K. E. A. Lundin, P. Marrack, M. Park, M. Sato-Hashimoto, J. Mrazek, S. Arita, M. Kweon, T. Cruz-Hernández, K. Kawana, T. Horikawa, Y. Fang, L. Larsson, H. Muta, C. Camarero, Y. Kinouchi, Y. Tsutsumi, K. Ramírez-Jiménez, M. Kverka, T. Obata, V. Soumelis, W. Ouyang, K. Adachi, S. Yamane, M. Deng, S. Park, H. Wang, M. Bono, D. Liu, R. R. Foshaug, A. Arakawa, K. Usui, Y. Kanazawa, P. Chiang, K. Hase, A. Shibuya, S. Miura, M. Yamazaki, Y. Kurashima, S. Ogawa, T. Kurita-Ochiai, J. Belacek, M. Jang, K. Nagano, M. L. Munoz-Roldan, M. Shimizu, B. C. Sydora, I. M. Arciniega-Martinez, X. Sun, A. Kormanovski-Kovsova, H. Kiyono, H. Kobayashi, I. Nakagawa, K. Kumagai, N. Ziv-Sokolovskaya, S. Kozuma, L. Gapin, P. N. Boyaka, E. Drago-Serrano, R. N. Fedorak, K. Shibata, T. Yoshikawa, D. You, A. De Andrés, Z. Venclikova, N. Itoh, R. Campos-Rodríguez, T. Nagatake, K. Kawano, N. Marín, L. J. DeTolla, Y. Minegishi, K. Shibuya, H. Yamada, H. Yan, Y. Iwakura, J. Bartova, S. Hori, J. Kopecny, M. Chien, K. Oda, Y. Murata, Z. Zakostelska, P. Michea, M. Sasaki, J. Kim, D. Musakhodjaeva, T. Iwamoto, M. H. Young, H. Ohnishi, C. Loddenkemper, T. Worbs, E. J. Albert, A. Kumanogoh, Y. Hanyu, K. Takatsu, T. Nomura, A. Resendiz-Albor, K. Sato, Y. Goto, G. Roy, M. J. Fial, R. Suzuki, M. Sugi, P. C. Wilson, K. Klimesova, M. Totsuka, T. Matozaki, S. Tahara-Hanaoka, K. Kadokura, Y. Abe, A. Bonnegarde, A. D. Keegan, K. Takagaki, S. Chang, M. Kawakami, P. Jiang, E. Stroblova, H. Kamada, Y. Jang, E. K. Persson, N. Takegahara, I. Nishimura, A. Gotoh, N. Zheng, H. Frøkiær, O. Frey, K. Beasley, R. M. White, K. Tomio, R. Iida, S. Kang, Y. Kawano, G. Rinot, S. Hachimura, H. Karasuyama, L. Luski, Y. Yoshizawa, J. Stamnaes, S. Kakuta, K. Tanabe, S. Mirete, R. Uchiyama, Tsuneyasu Kaisho, J. Kunisawa, T. Kouro, H. Cha, S. Kim, X. Liu, K. Nogawa, P. Rossmann, Y. Hamada, R. Apte, S. Honda, O. Pabst, Y. Fukuyama, S. Dotan, T. Hashizume, T. Kawashima, S. Sekine, T. Tobe, T. Shimosegawa, H. Kayamuro, M. Mauricas, Y. Taketani, I. D. Iliev, T. Fukaya, S. Bereswill, T. Mallevaey, H. Takagi, R. Hatano, F. Shamsiev, K. Kataoka, R. Sabat, N. Vynne, T. Fujii, D. Bruce, Y. Saito, N. Fayzullaeva, J. Jee, K. Fujihashi, N. M. Tsuji, Y. Supriatna, E. Smith, S. P. Chapoval, J. Jang, S. Wajima, T. Yokoyama, E. Jaensson, K. Maaetoft-Udsen, K. Wolk, M. M. Heimesaat, J. Pacheco-Yépez, L. Mesin, I. Arciniega-Martínez, and H. Iwamura

Subjects
Immune system, business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, Acquired immune system, business, Mucosal immunity
Published
2010

2. Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice.

Author

Bersudsky M, Luski L, Fishman D, White RM, Ziv-Sokolovskaya N, Dotan S, Rider P, Kaplanov I, Aychek T, Dinarello CA, Apte RN, and Voronov E

Subjects
Animals, Colitis chemically induced, Colitis pathology, Colon drug effects, Colon pathology, Colon physiopathology, Dextran Sulfate pharmacology, Disease Models, Animal, Interleukin-1 agonists, Intestinal Mucosa drug effects, Intestinal Mucosa pathology, Intestinal Mucosa physiopathology, Leukemic Infiltration physiopathology, Mice, Mice, Inbred C57BL, Mice, Knockout, T-Lymphocytes physiology, Colitis physiopathology, Interleukin-1alpha physiology, Interleukin-1beta physiology
Abstract

Objective: The differential role of the IL-1 agonists, IL-1α, which is mainly cell-associated versus IL-1β, which is mostly secreted, was studied in colon inflammation., Design: Dextran sodium sulfate (DSS) colitis was induced in mice globally deficient in either IL-1α or IL-1β, and in wild-type mice, or in mice with conditional deletion of IL-1α in intestinal epithelial cells (IECs). Bone marrow transplantation experiments were performed to assess the role of IL-1α or IL-1β of myeloid versus colon non-hematopoietic cells in inflammation and repair in acute colitis., Results: IL-1α released from damaged IECs acts as an alarmin by initiating and propagating colon inflammation, as IL-1α deficient mice exhibited mild disease symptoms with improved recovery. IL-1β is involved in repair of IECs and reconstitution of the epithelial barrier during the resolution of colitis; its deficiency correlates with disease exacerbation. Neutralisation of IL-1α in control mice during acute colitis led to alleviation of clinical and histological manifestations, whereas treatment with rIL-1Ra or anti-IL-1β antibodies was not effective. Repair after colitis correlated with accumulation of CD8 and regulatory T cells in damaged crypts., Conclusions: The role of IL-1α and IL-1β differs in DSS-induced colitis in that IL-1α, mainly of colon epithelial cells is inflammatory, whereas IL-1β, mainly of myeloid cell origin, promotes healing and repair. Given the dissimilar functions of each IL-1 agonistic molecule, an IL-1 receptor blockade would not be as therapeutically effective as specific neutralising of IL-1α, which leaves IL-1β function intact.

Published
2014
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