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1. An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism

Author: Joshua A. Lees, João M. Dias, Francis Rajamohan, Jean-Philippe Fortin, Rebecca O’Connor, Jimmy X. Kong, Emily A. G. Hughes, Ethan L. Fisher, Jamison B. Tuttle, Gabrielle Lovett, Bethany L. Kormos, Rayomand J. Unwalla, Lei Zhang, Anne-Marie Dechert Schmitt, Dahui Zhou, Michael Moran, Kimberly A. Stevens, Kimberly F. Fennell, Alison E. Varghese, Andrew Maxwell, Emmaline E. Cote, Yuan Zhang, and Seungil Han
Subjects: Science
Abstract: Abstract GPR61 is an orphan GPCR related to biogenic amine receptors. Its association with phenotypes relating to appetite makes it of interest as a druggable target to treat disorders of metabolism and body weight, such as obesity and cachexia. To date, the lack of structural information or a known biological ligand or tool compound has hindered comprehensive efforts to study GPR61 structure and function. Here, we report a structural characterization of GPR61, in both its active-like complex with heterotrimeric G protein and in its inactive state. Moreover, we report the discovery of a potent and selective small-molecule inverse agonist against GPR61 and structural elucidation of its allosteric binding site and mode of action. These findings offer mechanistic insights into an orphan GPCR while providing both a structural framework and tool compound to support further studies of GPR61 function and modulation.
Published: 2023
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2. Measurements of neutrino oscillation parameters from the T2K experiment using $$3.6\times 10^{21}$$ 3.6 × 10 21 protons on target

Author: K. Abe, N. Akhlaq, R. Akutsu, A. Ali, S. Alonso Monsalve, C. Alt, C. Andreopoulos, M. Antonova, S. Aoki, T. Arihara, Y. Asada, Y. Ashida, E. T. Atkin, M. Barbi, G. J. Barker, G. Barr, D. Barrow, M. Batkiewicz-Kwasniak, F. Bench, V. Berardi, L. Berns, S. Bhadra, A. Blanchet, A. Blondel, S. Bolognesi, T. Bonus, S. Bordoni, S. B. Boyd, A. Bravar, C. Bronner, S. Bron, A. Bubak, M. Buizza Avanzini, J. A. Caballero, N. F. Calabria, S. Cao, D. Carabadjac, A. J. Carter, S. L. Cartwright, M. G. Catanesi, A. Cervera, J. Chakrani, D. Cherdack, P. S. Chong, G. Christodoulou, A. Chvirova, M. Cicerchia, J. Coleman, G. Collazuol, L. Cook, A. Cudd, C. Dalmazzone, T. Daret, Yu. I. Davydov, A. De Roeck, G. De Rosa, T. Dealtry, C. C. Delogu, C. Densham, A. Dergacheva, F. Di Lodovico, S. Dolan, D. Douqa, T. A. Doyle, O. Drapier, J. Dumarchez, P. Dunne, K. Dygnarowicz, A. Eguchi, S. Emery-Schrenk, G. Erofeev, A. Ershova, G. Eurin, D. Fedorova, S. Fedotov, M. Feltre, A. J. Finch, G. A. Fiorentini Aguirre, G. Fiorillo, M. D. Fitton, J. M. Franco Patiño, M. Friend, Y. Fujii, Y. Fukuda, K. Fusshoeller, L. Giannessi, C. Giganti, V. Glagolev, M. Gonin, J. González Rosa, E. A. G. Goodman, A. Gorin, M. Grassi, M. Guigue, D. R. Hadley, J. T. Haigh, P. Hamacher-Baumann, D. A. Harris, M. Hartz, T. Hasegawa, S. Hassani, N. C. Hastings, Y. Hayato, D. Henaff, A. Hiramoto, M. Hogan, J. Holeczek, A. Holin, T. Holvey, N. T. Hong Van, T. Honjo, F. Iacob, A. K. Ichikawa, M. Ikeda, T. Ishida, M. Ishitsuka, H. T. Israel, K. Iwamoto, A. Izmaylov, N. Izumi, M. Jakkapu, B. Jamieson, S. J. Jenkins, C. Jesús-Valls, J. J. Jiang, P. Jonsson, S. Joshi, C. K. Jung, P. B. Jurj, M. Kabirnezhad, A. C. Kaboth, T. Kajita, H. Kakuno, J. Kameda, S. P. Kasetti, Y. Kataoka, Y. Katayama, T. Katori, M. Kawaue, E. Kearns, M. Khabibullin, A. Khotjantsev, T. Kikawa, H. Kikutani, S. King, V. Kiseeva, J. Kisiel, T. Kobata, H. Kobayashi, T. Kobayashi, L. Koch, S. Kodama, A. Konaka, L. L. Kormos, Y. Koshio, A. Kostin, T. Koto, K. Kowalik, Y. Kudenko, Y. Kudo, S. Kuribayashi, R. Kurjata, T. Kutter, M. Kuze, M. La Commara, L. Labarga, K. Lachner, J. Lagoda, S. M. Lakshmi, M. Lamers James, M. Lamoureux, A. Langella, J.-F. Laporte, D. Last, N. Latham, M. Laveder, L. Lavitola, M. Lawe, Y. Lee, C. Lin, S.-K. Lin, R. P. Litchfield, S. L. Liu, W. Li, A. Longhin, K. R. Long, A. Lopez Moreno, L. Ludovici, X. Lu, T. Lux, L. N. Machado, L. Magaletti, K. Mahn, M. Malek, M. Mandal, S. Manly, A. D. Marino, L. Marti-Magro, D. G. R. Martin, M. Martini, J. F. Martin, T. Maruyama, T. Matsubara, V. Matveev, C. Mauger, K. Mavrokoridis, E. Mazzucato, N. McCauley, J. McElwee, K. S. McFarland, C. McGrew, J. McKean, A. Mefodiev, G. D. Megias, P. Mehta, L. Mellet, C. Metelko, M. Mezzetto, E. Miller, A. Minamino, O. Mineev, S. Mine, M. Miura, L. Molina Bueno, S. Moriyama, P. Morrison, Th. A. Mueller, D. Munford, L. Munteanu, K. Nagai, Y. Nagai, T. Nakadaira, K. Nakagiri, M. Nakahata, Y. Nakajima, A. Nakamura, H. Nakamura, K. Nakamura, K. D. Nakamura, Y. Nakano, S. Nakayama, T. Nakaya, K. Nakayoshi, C. E. R. Naseby, T. V. Ngoc, V. Q. Nguyen, K. Niewczas, S. Nishimori, Y. Nishimura, K. Nishizaki, T. Nosek, F. Nova, P. Novella, J. C. Nugent, H. M. O’Keeffe, L. O’Sullivan, T. Odagawa, T. Ogawa, R. Okada, W. Okinaga, K. Okumura, T. Okusawa, N. Ospina, R. A. Owen, Y. Oyama, V. Palladino, V. Paolone, M. Pari, J. Parlone, S. Parsa, J. Pasternak, M. Pavin, D. Payne, G. C. Penn, D. Pershey, L. Pickering, C. Pidcott, G. Pintaudi, C. Pistillo, B. Popov, K. Porwit, M. Posiadala-Zezula, Y. S. Prabhu, F. Pupilli, B. Quilain, T. Radermacher, E. Radicioni, B. Radics, M. A. Ramírez, P. N. Ratoff, M. Reh, C. Riccio, E. Rondio, S. Roth, N. Roy, A. Rubbia, A. C. Ruggeri, C. A. Ruggles, A. Rychter, K. Sakashita, F. Sánchez, G. Santucci, C. M. Schloesser, K. Scholberg, M. Scott, Y. Seiya, T. Sekiguchi, H. Sekiya, D. Sgalaberna, A. Shaikhiev, F. Shaker, A. Shaykina, M. Shiozawa, W. Shorrock, A. Shvartsman, N. Skrobova, K. Skwarczynski, D. Smyczek, M. Smy, J. T. Sobczyk, H. Sobel, F. J. P. Soler, Y. Sonoda, A. J. Speers, R. Spina, I. A. Suslov, S. Suvorov, A. Suzuki, S. Y. Suzuki, Y. Suzuki, A. A. Sztuc, M. Tada, S. Tairafune, S. Takayasu, A. Takeda, Y. Takeuchi, K. Takifuji, H. K. Tanaka, Y. Tanihara, M. Tani, A. Teklu, V. V. Tereshchenko, N. Teshima, N. Thamm, L. F. Thompson, W. Toki, C. Touramanis, T. Towstego, K. M. Tsui, T. Tsukamoto, M. Tzanov, Y. Uchida, M. Vagins, D. Vargas, M. Varghese, G. Vasseur, C. Vilela, E. Villa, W. G. S. Vinning, U. Virginet, T. Vladisavljevic, T. Wachala, J. G. Walsh, Y. Wang, L. Wan, D. Wark, M. O. Wascko, A. Weber, R. Wendell, M. J. Wilking, C. Wilkinson, J. R. Wilson, K. Wood, C. Wret, J. Xia, Y.-H. Xu, K. Yamamoto, T. Yamamoto, C. Yanagisawa, G. Yang, T. Yano, K. Yasutome, N. Yershov, U. Yevarouskaya, M. Yokoyama, Y. Yoshimoto, N. Yoshimura, M. Yu, R. Zaki, A. Zalewska, J. Zalipska, K. Zaremba, G. Zarnecki, X. Zhao, T. Zhu, M. Ziembicki, E. D. Zimmerman, M. Zito, S. Zsoldos, and T2K Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The T2K experiment presents new measurements of neutrino oscillation parameters using $$19.7(16.3)\times 10^{20}$$ 19.7 ( 16.3 ) × 10 20 protons on target (POT) in (anti-)neutrino mode at the far detector (FD). Compared to the previous analysis, an additional $$4.7\times 10^{20}$$ 4.7 × 10 20 POT neutrino data was collected at the FD. Significant improvements were made to the analysis methodology, with the near-detector analysis introducing new selections and using more than double the data. Additionally, this is the first T2K oscillation analysis to use NA61/SHINE data on a replica of the T2K target to tune the neutrino flux model, and the neutrino interaction model was improved to include new nuclear effects and calculations. Frequentist and Bayesian analyses are presented, including results on $$\sin ^2\theta _{13}$$ sin 2 θ 13 and the impact of priors on the $$\delta _{\textrm{CP}}$$ δ CP measurement. Both analyses prefer the normal mass ordering and upper octant of $$\sin ^2\theta _{23}$$ sin 2 θ 23 with a nearly maximally CP-violating phase. Assuming the normal ordering and using the constraint on $$\sin ^2\theta _{13}$$ sin 2 θ 13 from reactors, $$\sin ^2\theta _{23}=0.561^{+0.021}_{-0.032}$$ sin 2 θ 23 = 0 . 561 - 0.032 + 0.021 using Feldman–Cousins corrected intervals, and $$\varDelta {}m^2_{32}=2.494_{-0.058}^{+0.041}\times 10^{-3}~\text {eV}^2$$ Δ m 32 2 = 2 . 494 - 0.058 + 0.041 × 10 - 3 eV 2 using constant $$\varDelta \chi ^{2}$$ Δ χ 2 intervals. The CP-violating phase is constrained to $$\delta _{\textrm{CP}}=-1.97_{-0.70}^{+0.97}$$ δ CP = - 1 . 97 - 0.70 + 0.97 using Feldman–Cousins corrected intervals, and $$\delta _{\textrm{CP}}=0,\pi $$ δ CP = 0 , π is excluded at more than 90% confidence level. A Jarlskog invariant of zero is excluded at more than $$2\sigma $$ 2 σ credible level using a flat prior in $$\delta _{\textrm{CP}},$$ δ CP , and just below $$2\sigma $$ 2 σ using a flat prior in $$\sin \delta _{\textrm{CP}}.$$ sin δ CP . When the external constraint on $$\sin ^2\theta _{13}$$ sin 2 θ 13 is removed, $$\sin ^2\theta _{13}=28.0^{+2.8}_{-6.5}\times 10^{-3},$$ sin 2 θ 13 = 28 . 0 - 6.5 + 2.8 × 10 - 3 , in agreement with measurements from reactor experiments. These results are consistent with previous T2K analyses.
Published: 2023
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3. Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels

Author: Rachel J. Roth Flach, Eliza Bollinger, Allan R. Reyes, Brigitte Laforest, Bethany L. Kormos, Shenping Liu, Matthew R. Reese, Luis A. Martinez Alsina, Leanne Buzon, Yuan Zhang, Bruce Bechle, Amy Rosado, Parag V. Sahasrabudhe, John Knafels, Samit K. Bhattacharya, Kiyoyuki Omoto, John C. Stansfield, Liam D. Hurley, LouJin Song, Lina Luo, Susanne B. Breitkopf, Mara Monetti, Teresa Cunio, Brendan Tierney, Frank J. Geoly, Jake Delmore, C. Parker Siddall, Liang Xue, Ka N. Yip, Amit S. Kalgutkar, Russell A. Miller, Bei B. Zhang, and Kevin J. Filipski
Subjects: Science
Abstract: Abstract Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which is inhibited by BCKDH kinase (BDK)-mediated phosphorylation. Screening efforts to discover BDK inhibitors led to identification of thiophene PF-07208254, which improved cardiometabolic endpoints in mice. Structure-activity relationship studies led to identification of a thiazole series of BDK inhibitors; however, these inhibitors did not improve metabolism in mice upon chronic administration. While the thiophenes demonstrated sustained branched chain ketoacid (BCKA) lowering and reduced BDK protein levels, the thiazoles increased BCKAs and BDK protein levels. Thiazoles increased BDK proximity to BCKDH-E2, whereas thiophenes reduced BDK proximity to BCKDH-E2, which may promote BDK degradation. Thus, we describe two BDK inhibitor series that possess differing attributes regarding BDK degradation or stabilization and provide a mechanistic understanding of the desirable features of an effective BDK inhibitor.
Published: 2023
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4. Sequential Pattern Mining of Longitudinal Adverse Events After Left Ventricular Assist Device Implant.

Author: Faezeh Movahedi, Robert L. Kormos, Lisa C. Lohmueller, Laura Seese, Manreet K. Kanwar, Srinivas Murali, Yiye Zhang, Rema Padman, and James F. Antaki
Published: 2020
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5. Correction: Understanding and Addressing Variation in Health Care–Associated Infections After Durable Ventricular Assist Device Therapy: Protocol for a Mixed Methods Study

Author: P Paul Chandanabhumma, Michael D Fetters, Francis D Pagani, Preeti N Malani, John M Hollingsworth, Russell J Funk, Keith D Aaronson, Min Zhang, Robert L Kormos, Carol E Chenoweth, Supriya Shore, Tessa M F Watt, Lourdes Cabrera, and Donald S Likosky
Subjects: Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Published: 2022
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6. Measurement of the charged-current electron (anti-)neutrino inclusive cross-sections at the T2K off-axis near detector ND280

Author: The T2K collaboration, K. Abe, N. Akhlaq, R. Akutsu, A. Ali, C. Alt, C. Andreopoulos, L. Anthony, M. Antonova, S. Aoki, A. Ariga, T. Arihara, Y. Asada, Y. Ashida, E. T. Atkin, Y. Awataguchi, S. Ban, M. Barbi, G. J. Barker, G. Barr, D. Barrow, C. Barry, M. Batkiewicz-Kwasniak, A. Beloshapkin, F. Bench, V. Berardi, L. Berns, S. Bhadra, S. Bienstock, A. Blondel, S. Bolognesi, T. Bonus, B. Bourguille, S. B. Boyd, D. Brailsford, A. Bravar, D. Bravo Berguño, C. Bronner, S. Bron, A. Bubak, M. Buizza Avanzini, J. Calcutt, T. Campbell, S. Cao, S. L. Cartwright, M. G. Catanesi, A. Cervera, A. Chappell, C. Checchia, D. Cherdack, N. Chikuma, G. Christodoulou, M. Cicerchia, J. Coleman, G. Collazuol, L. Cook, D. Coplowe, A. Cudd, A. Dabrowska, G. De Rosa, T. Dealtry, P. F. Denner, S. R. Dennis, C. Densham, F. Di Lodovico, N. Dokania, S. Dolan, T. A. Doyle, O. Drapier, J. Dumarchez, P. Dunne, A. Eguchi, L. Eklund, S. Emery-Schrenk, A. Ereditato, P. Fernandez, T. Feusels, A. J. Finch, G. A. Fiorentini, G. Fiorillo, C. Francois, M. Friend, Y. Fujii, R. Fujita, D. Fukuda, R. Fukuda, Y. Fukuda, K. Fusshoeller, C. Giganti, T. Golan, M. Gonin, A. Gorin, M. Guigue, D. R. Hadley, J. T. Haigh, P. Hamacher-Baumann, M. Hartz, T. Hasegawa, S. Hassani, N. C. Hastings, T. Hayashino, Y. Hayato, A. Hiramoto, M. Hogan, J. Holeczek, N. T. Hong Van, T. Honjo, F. Iacob, A. K. Ichikawa, M. Ikeda, T. Ishida, T. Ishii, M. Ishitsuka, K. Iwamoto, A. Izmaylov, N. Izumi, M. Jakkapu, B. Jamieson, S. J. Jenkins, C. Jesús-Valls, M. Jiang, S. Johnson, P. Jonsson, C. K. Jung, X. Junjie, P. B. Jurj, M. Kabirnezhad, A. C. Kaboth, T. Kajita, H. Kakuno, J. Kameda, D. Karlen, S. P. Kasetti, Y. Kataoka, Y. Katayama, T. Katori, Y. Kato, E. Kearns, M. Khabibullin, A. Khotjantsev, T. Kikawa, H. Kikutani, H. Kim, S. King, J. Kisiel, A. Knight, A. Knox, T. Kobata, T. Kobayashi, L. Koch, T. Koga, A. Konaka, L. L. Kormos, Y. Koshio, A. Kostin, K. Kowalik, H. Kubo, Y. Kudenko, N. Kukita, S. Kuribayashi, R. Kurjata, T. Kutter, M. Kuze, L. Labarga, J. Lagoda, M. Lamoureux, D. Last, M. Laveder, M. Lawe, M. Licciardi, T. Lindner, R. P. Litchfield, S. L. Liu, X. Li, A. Longhin, L. Ludovici, X. Lu, T. Lux, L. N. Machado, L. Magaletti, K. Mahn, M. Malek, S. Manly, L. Maret, A. D. Marino, L. Marti-Magro, J. F. Martin, T. Maruyama, T. Matsubara, K. Matsushita, V. Matveev, C. Mauger, K. Mavrokoridis, E. Mazzucato, M. McCarthy, N. McCauley, J. McElwee, K. S. McFarland, C. McGrew, A. Mefodiev, C. Metelko, M. Mezzetto, A. Minamino, O. Mineev, S. Mine, M. Miura, L. Molina Bueno, S. Moriyama, J. Morrison, Th. A. Mueller, L. Munteanu, S. Murphy, Y. Nagai, T. Nakadaira, M. Nakahata, Y. Nakajima, A. Nakamura, K. G. Nakamura, K. Nakamura, Y. Nakano, S. Nakayama, T. Nakaya, K. Nakayoshi, C. Nantais, C. E. R. Naseby, T. V. Ngoc, K. Niewczas, K. Nishikawa, Y. Nishimura, E. Noah, T. S. Nonnenmacher, F. Nova, P. Novella, J. Nowak, J. C. Nugent, H. M. O’Keeffe, L. O’Sullivan, T. Odagawa, T. Ogawa, R. Okada, K. Okumura, T. Okusawa, S. M. Oser, R. A. Owen, Y. Oyama, V. Palladino, J. L. Palomino, V. Paolone, M. Pari, W. C. Parker, S. Parsa, J. Pasternak, P. Paudyal, M. Pavin, D. Payne, G. C. Penn, L. Pickering, C. Pidcott, G. Pintaudi, E. S. Pinzon Guerra, C. Pistillo, B. Popov, K. Porwit, M. Posiadala-Zezula, A. Pritchard, B. Quilain, T. Radermacher, E. Radicioni, B. Radics, P. N. Ratoff, E. Reinherz-Aronis, C. Riccio, E. Rondio, S. Roth, A. Rubbia, A. C. Ruggeri, C. A. Ruggles, A. Rychter, K. Sakashita, F. Sánchez, G. Santucci, C. M. Schloesser, K. Scholberg, J. Schwehr, M. Scott, Y. Seiya, T. Sekiguchi, H. Sekiya, D. Sgalaberna, R. Shah, A. Shaikhiev, F. Shaker, A. Shaykina, M. Shiozawa, W. Shorrock, A. Shvartsman, A. Smirnov, M. Smy, J. T. Sobczyk, H. Sobel, F. J. P. Soler, Y. Sonoda, J. Steinmann, S. Suvorov, A. Suzuki, S. Y. Suzuki, Y. Suzuki, A. A. Sztuc, M. Tada, M. Tajima, A. Takeda, Y. Takeuchi, H. K. Tanaka, H. A. Tanaka, S. Tanaka, Y. Tanihara, M. Tani, N. Teshima, L. F. Thompson, W. Toki, C. Touramanis, T. Towstego, K. M. Tsui, T. Tsukamoto, M. Tzanov, Y. Uchida, M. Vagins, S. Valder, Z. Vallari, D. Vargas, G. Vasseur, C. Vilela, W. G. S. Vinning, T. Vladisavljevic, V. V. Volkov, T. Wachala, J. Walker, J. G. Walsh, Y. Wang, D. Wark, M. O. Wascko, A. Weber, R. Wendell, M. J. Wilking, C. Wilkinson, J. R. Wilson, R. J. Wilson, K. Wood, C. Wret, Y. Yamada, K. Yamamoto, C. Yanagisawa, G. Yang, T. Yano, K. Yasutome, S. Yen, N. Yershov, M. Yokoyama, T. Yoshida, M. Yu, A. Zalewska, J. Zalipska, K. Zaremba, G. Zarnecki, M. Ziembicki, E. D. Zimmerman, M. Zito, S. Zsoldos, and A. Zykova
Subjects: Other experiments, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The electron (anti-)neutrino component of the T2K neutrino beam constitutes the largest background in the measurement of electron (anti-)neutrino appearance at the far detector. The electron neutrino scattering is measured directly with the T2K off-axis near detector, ND280. The selection of the electron (anti-)neutrino events in the plastic scintillator target from both neutrino and anti-neutrino mode beams is discussed in this paper. The flux integrated single differential charged-current inclusive electron (anti-)neutrino cross-sections, dσ/dp and dσ/d cos(θ), and the total cross-sections in a limited phase-space in momentum and scattering angle (p > 300 MeV/c and θ ≤ 45°) are measured using a binned maximum likelihood fit and compared to the neutrino Monte Carlo generator predictions, resulting in good agreement.
Published: 2020
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7. Creation and Validation of a Novel Sex‐Specific Mortality Risk Score in LVAD Recipients

Author: Aditi Nayak, Yingtian Hu, Yi‐An Ko, Rebecca Steinberg, Subrat Das, Anurag Mehta, Chang Liu, John Pennington, Rongbing Xie, James K. Kirklin, Robert L. Kormos, Jennifer Cowger, Marc A. Simon, and Alanna A. Morris
Subjects: left ventricular assist device, mortality, prognosis, risk score, sex disparity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Background Prior studies have shown that women have worse 3‐month survival after receiving a left ventricular assist device compared with men. Currently used prognostic scores, including the Heartmate II Risk Score, do not account for the increased residual risk in women. We used the IMACS (International Society for Heart and Lung Transplantation Mechanically Assisted Circulatory Support) registry to create and validate a sex‐specific risk score for early mortality in left ventricular assist device recipients. Methods and Results Adult patients with a continuous‐flow LVAD from the IMACS registry were randomly divided into a derivation cohort (DC; n=9113; 21% female) and a validation cohort (VC; n=6074; 21% female). The IMACS Risk Score was developed in the DC to predict 3‐month mortality, from preoperative candidate predictors selected using the Akaike information criterion, or significant sex × variable interaction. In the DC, age, cardiogenic shock at implantation, body mass index, blood urea nitrogen, bilirubin, hemoglobin, albumin, platelet count, left ventricular end‐diastolic diameter, tricuspid regurgitation, dialysis, and major infection before implantation were retained as significant predictors of 3‐month mortality. There was significant ischemic heart failure × sex and platelet count × sex interaction. For each quartile increase in IMACS risk score, men (odds ratio [OR], 1.86; 95% CI, 1.74–2.00; P
Published: 2021
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8. Graft Resistance Difference after HVAD to HeartMate 3 Left Ventricular Assist Device Exchange

Author: Kevin Bourque, Matthew J. Martin, Daniel I. Harjes, David L. Cassidy, Francis D. Pagani, and Robert L. Kormos
Subjects: Heart Failure, Chicago, Pulmonary and Respiratory Medicine, Humans, Surgery, Heart-Assist Devices, Cardiology and Cardiovascular Medicine
Abstract: A likely consequence of the discontinued distribution and sale of the HVAD System (Medtronic, Minneapolis, MN) will be an increase in replacement with the HeartMate 3 (Abbott, Chicago, IL) left ventricular assist device when device exchange is necessary. If part or all of the HVAD 10-mm-diameter outflow graft is retained during replacement, the HeartMate 3 will have to run at a higher speed than it would with its 14-mm-diameter graft.A steady-state, in vitro study was run with 250-mm-long samples of HVAD, HeartMate 3, and half-HVAD/half-HeartMate 3 grafts and additionally 125- and 375-mm-long samples of the HVAD graft. Flows of 3.0, 3.9, 4.3, 4.7, and 6.0 L/min were applied to encompass expected clinical conditions.At typical and high flow rates of 4.3 and 6.0 L/min, HeartMate 3 rotor speeds with the full HVAD graft had to be increased relative to those with the HeartMate 3 graft from 5350 to 5700 and 6350 to 6900 rpm, respectively, with power consumption increases from 3.7 to 4.3 W (16%) and 5.5 to 6.8 W (24%), respectively.The study did not elucidate a severe consequence of using a remnant HVAD graft during pump exchange, but the incremental risks of a higher rotor speed, disadvantage to the patient in battery runtime, and the general benefit of complete conversion to the HeartMate 3 graft should be balanced against other procedural considerations. Complete graft replacement during HVAD-to-HeartMate 3 conversion remains the preferred approach from an engineering point of view.
Published: 2022
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9. An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism

Author: Joshua A. Lees, João M. Dias, Francis Rajamohan, Jean-Philippe Fortin, Rebecca O’Connor, Jimmy X. Kong, Emily Hughes, Ethan L. Fisher, Jamison B. Tuttle, Gabrielle Lovett, Bethany L. Kormos, Rayomand J. Unwalla, Lei Zhang, Anne-Marie Dechert Schmidt, Dahui Zhou, Kimberly A. Stevens, Kimberly F. Fennell, Alison E. Varghese, Andrew Maxwell, Emmaline E. Cote, Yuan Zhang, and Seungil Han
Abstract: GPR61 is a biogenic amine receptor-related orphan GPCR associated with phenotypes relating to appetite and thus, is of interest as a druggable target to treat disorders of metabolism and body weight, such as obesity and cachexia. To date, lack of structural information or a known biological ligand or tool compound has hindered comprehensive efforts to study its structure and function. Here, we report the first ever structural characterization of GPR61, in both its active-like complex with heterotrimeric G protein and in its inactive state. Moreover, we report the discovery of a potent and selective small-molecule inverse agonist against GPR61 and structural elucidation of its unprecedented allosteric site and mode of action. These findings offer key mechanistic insights into an orphan GPCR, while providing both a new structural framework and tool compound to support further studies of GPR61 function and modulation.
Published: 2023
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10. Electromagnetic Interference from Left Ventricular Assist Device (LVAD) Inhibiting the Pacing Function of an Implantable Cardioverter-Defibrillator (ICD) Device

Author: Sebhat Erqou, Robert L. Kormos, Norman C. Wang, Dennis M. McNamara, and Raveen Bazaz
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: There is an increasing prevalence of patients with concomitant implantable cardioverter-defibrillators (ICDs) and left ventricular devices (LVADs). The potential for negative interactions between these continually evolving technologies is a valid concern. Previously reported interactions include inappropriate ICD therapy and interference with ICD telemetry function. Understanding the nature of such interactions and developing a comprehensive strategy to approach such situations are important. In this report, we describe a case of electromagnetic interference from LVAD inhibiting the pacing function of an ICD that was corrected by reprograming the device. We would encourage investigators to review patients with ICD and LVAD in their institutions in order to help assess the frequency and nature of these and other interactions.
Published: 2018
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11. A Classification Approach for Risk Prognosis of Patients on Mechanical Ventricular Assistance.

Author: Yajuan Wang, Carolyn Penstein Rosé, Antonio Ferreira 0002, Dennis M. McNamara, Robert L. Kormos, and James F. Antaki
Published: 2010
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12. Supernova model discrimination with hyper-kamiokande

Author: Y. Nagao, H. Tanaka, A. Minamino, B. Navarro-Garcia, Z. Xie, L. Nascimento Machado, J. Lagoda, M. Shinoki, S. Cuen-Rochin, Arman Esmaili, F. Ballester, S. Parsa, N. McCauley, Jung-Hyun Kim, K. Frankiewicz, L. L. Kormos, Masaki Ishitsuka, M. Malek, V. Valentino, N. Kazarian, T. Wachala, E. Drakopoulou, G. Grella, V. Paolone, L. F. Thompson, A. K. Tomatani-Sánchez, A. Blanchet, R. A. Wendell, John Ellis, J. Y. Kim, N. W. Prouse, O. V. Mineev, M. R. Vagins, T. Boschi, T. Lindner, J. González-Nuevo, Hiroshi Ito, N. Skrobova, M. La Commara, L. Gialanella, F. Orozco-Luna, T. Kumita, A. Garfagnini, S. H. Jeon, A. Dergacheva, Hiroaki Menjo, A. T. Suzuki, K. Okamoto, C. E. R. Naseby, J. F. Martin, T. Iijima, M. Mezzetto, G. Ricciardi, J. R. Wilson, P. Gumplinger, Y. Takemoto, G. Galinski, K. Zaremba, T. Nakadaira, D. Vivolo, A. Carroll, C. Vilela, A. Blondel, A. Rychter, T. A. Doyle, C. Garde, G. De Rosa, A. Oshlianskyi, Hiroyuki Sekiya, R. Matsumoto, G. Pastuszak, P. J. Rajda, F. Monrabal, Yoichi Asaoka, G. Díaz López, K. L. Stankevich, C. D. Shin, Y. Fukuda, Yuto Ashida, Michal Malinský, T. Suganuma, B. Radics, Kohta Murase, Marco Grassi, P. Mehta, F. Cafagna, Ahmed Ali, L. Koerich, Vincenzo Berardi, Etam Noah, F. J. P. Soler, Alan Cosimo Ruggeri, M. Kekic, G. Vasseur, S. Wronka, M. Thiesse, B. Ferrazzi, K. Iwamoto, Yu. Kudenko, Atsushi Takeda, Kendall Mahn, David Hadley, B. Roskovec, M. Bergevin, A. Korzenev, J.J. Gómez-Cadenas, M. Batkiewicz-Kwasniak, M. Tzanov, M. Ikeda, Federico Sanchez, W. Obrębski, H. S. Jo, Y. Takeuchi, Piotr Kalaczyński, S. Chakraborty, J. C. Nugent, S. King, P. Paganini, M. Miura, F. Ameli, D. N. Yeum, C. J. Metelko, Akito Araya, T. Kajita, M. Tanaka, I. T. Lim, L. Mellet, S. Y. Kim, S. Bolognesi, A. Bravar, J. S. Jang, D. Svirida, A. Fiorentini, J. Renner, M. Chabera, L. O'Sullivan, V. Herrero, F. Iacob, K. Nakamura, Ko Okumura, Lukasz Stawarz, N. Ogawa, Laura Bonavera, Y. Maekawa, Takatomi Yano, Ll. Marti, H. J. Rose, S. El Hedri, L. Maret, G. Zarnecki, L. Bernard, S. H. Seo, H. Nakamura, H. Ozaki, A. P. Kryukov, A. Popov, Hisakazu Minakata, M. Buizza Avanzini, P. Sarmah, K. Martens, Sergio Luis Suárez Gómez, Hiroaki Aihara, V. Lezaun, G. A. Cowan, C. Riccio, S. Garode, R. Akutsu, M. Lamers James, T. Nicholls, I. Alekseev, K. Kowalik, J. Kasperek, T. Zakrzewski, S. B. Kim, T. Kutter, Evan O'Connor, B. Jamieson, F. Nova, M. Barbi, Xianguo Lu, Y. Sonoda, M. Friend, Teppei Katori, L. H. V. Anthony, A. Shaikhiev, C. J. Densham, V. Gousy-Leblanc, I. Bandac, J. H. Choi, S. Sano, A. K. Ichikawa, Magda Cicerchia, S. Valder, S. Roth, J. Kameda, M. Zito, A. Vijayvargi, S. Nakai, Y. Kotsar, K. M. Tsui, K. Hoshina, K. K. Joo, C. Pastore, T. Marchi, K. Niewczas, K. Nakayoshi, G. Fiorillo, C. McGrew, P. F. Loverre, S. Playfer, G.D. Barr, L. Labarga, T. Kobayashi, E. S. Pinzon Guerra, André Rubbia, D. Karlen, Th. A. Mueller, L. Koch, F. J. Mora, M. M. Khabibullin, Hidekazu Kakuno, Yoshitaka Itow, H. K. Tanaka, P. Adrich, Jeong-Eun Lee, S. Samani, M. G. Catanesi, M. Yu, M. J. Wilking, Robert Svoboda, P. Mijakowski, N. Kolev, Yu. Onishchuk, A. Kato, J. M. Poutissou, C. Bronner, Yutaka Nakajima, B. Richards, C. Ruggles, M. Needham, P. Jonsson, Y. Hayato, S. Mine, A. Konaka, L. Munteanu, Kunio Inoue, O. Drapier, Kenneth Long, M. McCarthy, T. Kinoshita, G. Tortone, Yuuki Nakano, T. Feusels, N. Izumi, Reetanjali Moharana, T. Dealtry, S. Hassani, G. Pronost, K. Sakashita, J. G. Learned, H. M. O'Keeffe, Shintaro Ito, E. Rondio, Toru Ogitsu, D. A. Patel, Tatiana Ovsiannikova, M. Guigue, Yusuke Koshio, T. Matsubara, S. M. Stellacci, R. J. Wilkes, G. Santucci, S. Y. Suzuki, S. D. Rountree, K. Zietara, A. A. Quiroga, M. Jakkapu, A. Boiano, L. Berns, M. O. Wascko, M. M. Vyalkov, K. Porwit, M. Taani, A. Evangelisti, I. Sashima, Michal Dziewiecki, J. Feng, Y. Seiya, M. Yonenaga, B. Spisso, B. W. Pointon, C. M. Mollo, N. Booth, S. V. Cao, N. Ospina, A. J. Finch, V. Takhistov, E. Radicioni, P. Przewlocki, S. Nakayama, S. Yen, T. Sekiguchi, Yudai Suwa, J. M. Calvo-Mozota, S. Zsoldos, C. Checchia, M. Posiadala-Zezula, E. O'Sullivan, Janusz Marzec, F. Retiere, Jan T. Sobczyk, P. Migliozzi, S. Borjabad, I. Di Palma, John Hill, K. A. Kouzakov, D. L. Wark, L. Cook, D. Sgalaberna, E. W. Miller, M. Lamoureux, M. Y. Pac, S. Russo, S. L. Cartwright, Yasunari Suzuki, D. Bose, B. Zaldivar, D. Martin, Dongsu Ryu, Z. Shan, S. Miki, M. Jiang, J. Kisiel, N. Yershov, M. Matusiak, C. Pea-Garay, K. Sato, Jesús Daniel Santos, Y. Yamaguchi, D. Bravo-Berguo, Chad Finley, T. Tashiro, Lawrence D. Brown, A. Gorin, Hiromasa Tanaka, M. Ziembicki, T. Vladisavljevic, J. Zalipska, J. Insler, C. Yanagisawa, Abinash Medhi, L. Kravchuk, W. Idrissi Ibnsalih, Hirokazu Ishino, J. Bian, K. Magar, S. Cebrian, Philippe Mermod, R. Gornea, Juan Pedro Ochoa-Ricoux, Sergei Fedotov, S. Izumiyama, C. Bozza, R. Esteve, Seiko Hirota, T. Tsukamoto, K. Skwarczynski, E. De la Fuente, T. Kikawa, M. Gonin, J. Xia, Intae Yu, Gareth J. Barker, A. Marinelli, E. Kearns, L. Lavitola, Michal Ostrowski, N. Deshmukh, Y. Kataoka, F. d. M. Blaszczyk, Carsten Rott, C. Mariani, T. Ishida, Roberto Spina, J. W. Seo, Masashi Yokoyama, F. Gramegna, K. Hultqvist, G. Collazuol, P. Spradlin, Gus Sinnis, A. Takenaka, T. Xin, M. Bellato, Yuki Fujii, Mark Scott, J. A. Hernando-Morata, P. Ferrario, A. Buchowicz, S. J. Jenkins, J. Walker, J. Toledo, Pablo Fernandez, Sandhya Choubey, S. Emery, A. Mefodiev, R.P. Kurjata, M. Mongelli, J. Dumarchez, Tsuyoshi Nakaya, M. Antonova, M. Danilov, M. Feely, A. Holin, Ara Ioannisian, B. A. Popov, K Stopa, W. G. S. Vinning, M. L. Sánchez, Masato Shiozawa, L. Ludovici, J. Gao, S. Bhadra, Koji Ishidoshiro, Hiroshi Nunokawa, V. Aushev, M. Hartz, I. Shimizu, C. S. Moon, M. B. Smy, S. Matsuno, I. Anghel, J. Migenda, T. Mondal, F. Di Lodovico, M. Tada, D. J. Payne, M. Kuze, N. C. Hastings, P. Di Meo, Y. Nishimura, M. Inomoto, L. Magaletti, C. Giganti, A. Klekotko, Patrick Dunne, J. Yoo, M. C. Sanchez, A. N. Khotjantsev, Kyujin Kwak, Lars Eklund, M. Lawe, A. Mitra, H. W. Sobel, Jürgen Pozimski, Yasuhiro Makida, A. Bubak, Jaroslaw Pasternak, B. Quilain, R. Leitner, Marco Laveder, J. P. Coleman, N. F. Calabria, H. I. Jang, S. B. Boyd, Moon Moon Devi, M. Fitton, M. Harada, Artur F. Izmaylov, J. McElwee, Shunsaku Horiuchi, P. de Perio, K. Nakagiri, Y. Kano, M. Rescigno, S. Moriyama, Masayuki Nakahata, C. Pidcott, Y. Uchida, V. Palladino, A. Longhin, A. Shaykina, Michelangelo Pari, Akimichi Taketa, Yuichi Oyama, S. Suvorov, R. P. Litchfield, D. H. Moon, Katsuki Hiraide, M. Pavin, M. Koga, R. B. Vogelaar, Enrique Fernandez-Martinez, B. L. Hartfiel, Koji Yamamoto, K. Ohta, K. Abe, Alexander Studenikin, E. Mazzucato, Elisa Bernardini, Abe, K., Adrich, P., Aihara, H., Akutsu, R., Alekseev, I., Ali, A., Ameli, F., Anghel, I., Anthony, L. H. V., Antonova, M., Araya, A., Asaoka, Y., Ashida, Y., Aushev, V., Ballester, F., Bandac, I., Barbi, M., Barker, G. J., Barr, G., Batkiewicz-Kwasniak, M., Bellato, M., Berardi, V., Bergevin, M., Bernard, L., Bernardini, E., Berns, L., Bhadra, S., Bian, J., Blanchet, A., Blaszczyk, F. D. M., Blondel, A., Boiano, A., Bolognesi, S., Bonavera, L., Booth, N., Borjabad, S., Boschi, T., Bose, D., Boyd, S. B., Bozza, C., Bravar, A., Bravo-Berguo, D., Bronner, C., Brown, L., Bubak, A., Buchowicz, A., Buizza Avanzini, M., Cafagna, F. S., Calabria, N. F., Calvo-Mozota, J. M., Cao, S., Cartwright, S. L., Carroll, A., Catanesi, M. G., Cebrian, S., Chabera, M., Chakraborty, S., Checchia, C., Choi, J. H., Choubey, S., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cowan, G., Cuen-Rochin, S., Danilov, M., Diaz Lopez, G., De La Fuente, E., De Perio, P., De Rosa, G., Dealtry, T., Densham, C. J., Dergacheva, A., Deshmukh, N., Devi, M. M., Di Lodovico, F., Di Meo, P., Di Palma, I., Doyle, T. A., Drakopoulou, E., Drapier, O., Dumarchez, J., Dunne, P., Dziewiecki, M., Eklund, L., El Hedri, S., Ellis, J., Emery, S., Esmaili, A., Esteve, R., Evangelisti, A., Feely, M., Fedotov, S., Feng, J., Fernandez, P., Fernandez-Martinez, E., Ferrario, P., Ferrazzi, B., Feusels, T., Finch, A., Finley, C., Fiorentini, A., Fiorillo, G., Fitton, M., Frankiewicz, K., Friend, M., Fujii, Y., Fukuda, Y., Galinski, G., Gao, J., Garde, C., Garfagnini, A., Garode, S., Gialanella, L., Giganti, C., Gomez-Cadenas, J. J., Gonin, M., Gonzalez-Nuevo, J., Gorin, A., Gornea, R., Gousy-Leblanc, V., Gramegna, F., Grassi, M., Grella, G., Guigue, M., Gumplinger, P., Hadley, D. R., Harada, M., Hartfiel, B., Hartz, M., Hassani, S., Hastings, N. C., Hayato, Y., Hernando-Morata, J. A., Herrero, V., Hill, J., Hiraide, K., Hirota, S., Holin, A., Horiuchi, S., Hoshina, K., Hultqvist, K., Iacob, F., Ichikawa, A. K., Idrissi Ibnsalih, W., Iijima, T., Ikeda, M., Inomoto, M., Inoue, K., Insler, J., Ioannisian, A., Ishida, T., Ishidoshiro, K., Ishino, H., Ishitsuka, M., Ito, H., Ito, S., Itow, Y., Iwamoto, K., Izmaylov, A., Izumi, N., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, H. I., Jang, J. S., Jenkins, S. J., Jeon, S. H., Jiang, M., Jo, H. S., Jonsson, P., Joo, K. K., Kajita, T., Kakuno, H., Kameda, J., Kano, Y., Kalaczynski, P., Karlen, D., Kasperek, J., Kataoka, Y., Kato, A., Katori, T., Kazarian, N., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kekic, M., Kim, J. H., Kim, J. Y., Kim, S. B., Kim, S. Y., King, S., Kinoshita, T., Kisiel, J., Klekotko, A., Kobayashi, T., Koch, L., Koga, M., Koerich, L., Kolev, N., Konaka, A., Kormos, L. L., Koshio, Y., Korzenev, A., Kotsar, Y., Kouzakov, K. A., Kowalik, K. L., Kravchuk, L., Kryukov, A. P., Kudenko, Y., Kumita, T., Kurjata, R., Kutter, T., Kuze, M., Kwak, K., La Commara, M., Labarga, L., Lagoda, J., Lamers James, M., Lamoureux, M., Laveder, M., Lavitola, L., Lawe, M., Learned, J. G., Lee, J., Leitner, R., Lezaun, V., Lim, I. T., Lindner, T., Litchfield, R. P., Long, K. R., Longhin, A., Loverre, P., Lu, X., Ludovici, L., Maekawa, Y., Magaletti, L., Magar, K., Mahn, K., Makida, Y., Malek, M., Malinsky, M., Marchi, T., Maret, L., Mariani, C., Marinelli, A., Martens, K., Marti, L., Martin, J. F., Martin, D., Marzec, J., Matsubara, T., Matsumoto, R., Matsuno, S., Matusiak, M., Mazzucato, E., Mccarthy, M., Mccauley, N., Mcelwee, J., Mcgrew, C., Mefodiev, A., Medhi, A., Mehta, P., Mellet, L., Menjo, H., Mermod, P., Metelko, C., Mezzetto, M., Migenda, J., Migliozzi, P., Mijakowski, P., Miki, S., Miller, E. W., Minakata, H., Minamino, A., Mine, S., Mineev, O., Mitra, A., Miura, M., Moharana, R., Mollo, C. M., Mondal, T., Mongelli, M., Monrabal, F., Moon, D. H., Moon, C. S., Mora, F. J., Moriyama, S., Mueller, T. A., Munteanu, L., Murase, K., Nagao, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakai, S., Nakajima, Y., Nakamura, K., Nakamura, K. I., Nakamura, H., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Nascimento Machado, L., Naseby, C. E. R., Navarro-Garcia, B., Needham, M., Nicholls, T., Niewczas, K., Nishimura, Y., Noah, E., Nova, F., Nugent, J. C., Nunokawa, H., Obrebski, W., Ochoa-Ricoux, J. P., O'Connor, E., Ogawa, N., Ogitsu, T., Ohta, K., Okamoto, K., O'Keeffe, H. M., Okumura, K., Onishchuk, Y., Orozco-Luna, F., Oshlianskyi, A., Ospina, N., Ostrowski, M., O'Sullivan, E., O'Sullivan, L., Ovsiannikova, T., Oyama, Y., Ozaki, H., Pac, M. Y., Paganini, P., Palladino, V., Paolone, V., Pari, M., Parsa, S., Pasternak, J., Pastore, C., Pastuszak, G., Patel, D. A., Pavin, M., Payne, D., Pea-Garay, C., Pidcott, C., Pinzon Guerra, E., Playfer, S., Pointon, B. W., Popov, A., Popov, B., Porwit, K., Posiadala-Zezula, M., Poutissou, J. -M., Pozimski, J., Pronost, G., Prouse, N. W., Przewlocki, P., Quilain, B., Quiroga, A. A., Radicioni, E., Radics, B., Rajda, P. J., Renner, J., Rescigno, M., Retiere, F., Ricciardi, G., Riccio, C., Richards, B., Rondio, E., Rose, H. J., Roskovec, B., Roth, S., Rott, C., Rountree, S. D., Rubbia, A., Ruggeri, A. C., Ruggles, C., Russo, S., Rychter, A., Ryu, D., Sakashita, K., Samani, S., Sanchez, F., Sanchez, M. L., Sanchez, M. C., Sano, S., Santos, J. D., Santucci, G., Sarmah, P., Sashima, I., Sato, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Seo, S. H., Sgalaberna, D., Shaikhiev, A., Shan, Z., Shaykina, A., Shimizu, I., Shin, C. D., Shinoki, M., Shiozawa, M., Sinnis, G., Skrobova, N., Skwarczynski, K., Smy, M. B., Sobczyk, J., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Spina, R., Spisso, B., Spradlin, P., Stankevich, K. L., Stawarz, L., Stellacci, S. M., Stopa, K., Studenikin, A. I., Suarez Gomez, S. L., Suganuma, T., Suvorov, S., Suwa, Y., Suzuki, A. T., Suzuki, S. Y., Suzuki, Y., Svirida, D., Svoboda, R., Taani, M., Tada, M., Takeda, A., Takemoto, Y., Takenaka, A., Taketa, A., Takeuchi, Y., Takhistov, V., Tanaka, H., Tanaka, H. A., Tanaka, H. I., Tanaka, M., Tashiro, T., Thiesse, M., Thompson, L. F., Toledo, J., Tomatani-Sanchez, A. K., Tortone, G., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Valder, S., Valentino, V., Vasseur, G., Vijayvargi, A., Vilela, C., Vinning, W. G. S., Vivolo, D., Vladisavljevic, T., Vogelaar, R. B., Vyalkov, M. M., Wachala, T., Walker, J., Wark, D., Wascko, M. O., Wendell, R. A., Wilkes, R. J., Wilking, M. J., Wilson, J. R., Wronka, S., Xia, J., Xie, Z., Xin, T., Yamaguchi, Y., Yamamoto, K., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yeum, D. N., Yokoyama, M., Yonenaga, M., Yoo, J., Yu, I., Yu, M., Zakrzewski, T., Zaldivar, B., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zietara, K., Zito, M., Zsoldos, S., Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Hyper-Kamiokande, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics - Instrumentation and Detectors, 09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación, KAMIOKANDE, Astrophysics, 01 natural sciences, neutrino: flux, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), neutrino, accretion, black hole, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Core-collapse supernovae, neutron star, Monte Carlo, physics.ins-det, 010303 astronomy & astrophysics, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Instrumentation and Detectors (physics.ins-det), 16. Peace & justice, Supernova, neutrino: detector, 07.- Asegurar el acceso a energías asequibles, fiables, sostenibles y modernas para todos, supernova, neutrino astronomy, neutrino physics, Neutrino detector, Neutrino, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, supernova: collapse, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Observable universe, Astrophysics::Cosmology and Extragalactic Astrophysics, Hyper-Kamiokande, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], High energy physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics, hep-ex, 010308 nuclear & particles physics, supernova: model, Astronomy and Astrophysics, Galaxy, Black hole, Neutron star, Space and Planetary Science, neutrino: burst, galaxy, Neutrino astronomy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], astro-ph.IM
Abstract: Autorzy: Abe K., Adrich P., Aihara H., Akutsu, R., Alekseev I., Ali A. , Ameli F., Anghel I., Anthony L. H. V., Antonova M. , Araya A., Asaoka Y., Ashida Y., Aushev V., Ballester F., Bandac I., Barbi M., Barker G. J., Barr G., Batkiewicz-Kwasniak M., Bellato M., Berardi V., Bergevin M., Bernard L., Bernardini E., Berns L., Bhadra S., Bian J., Blanchet A., Blaszczyk F. d. M., Blonde A., Boiano A., Bolognesi S., Bonavera L., Booth N., Borjabad S., Boschi, T., Bose D., Boyd S . B., Bozza C., Bravar A., Bravo-Berguño D., Bronner C., Brown L., Bubak Arkadiusz, Buchowicz A., Buizza Avanzini M., Cafagna F. S., Calabria N. F., Calvo-Mozota J. M., Cao S., Cartwright S.L., Carroll A., Catanesi M. G., Cebriàn, S., Chabera M., Chakraborty, S., Checchia C., Choi J.H., Choubey S., Cicerchia M., Coleman J., Collazuol G., Cook L., Cowan G., Cuen-Rochin, S., Danilov M., Díaz López G., De la Fuente E., de Perio P., De Rosa G., Dealtry T., Densham C. J., Dergacheva A., Deshmukh N., Devi M. M., Di Lodovico F., Di Meo, P., Di Palma I., Doyle T. A., Drakopoulou E., Drapier O., Dumarchez J., Dunne P., Dziewiecki M., Eklund L., El Hedri S., Ellis J., Emery S., Esmaili A., Esteve R., Evangelisti A., Feely M., Fedotov S., Feng J., Fernandez P., Fernández-Martinez E., Ferrario P., Ferrazzi,B., Feusels T., Finch A., Finley C., Fiorentini A., Fiorillo G., Fitton M., Frankiewicz K., Friend M., Fujii Y., Fukuda Y., Galinski G., Gao J., Garde C., Garfagnini A., Garode S., Gialanella L., Giganti C., Gomez-Cadenas J.J., Gonin M., González-Nuevo J., Gorin A., Gornea R., Gousy-Leblanc V. Gramegna F. Grassi M. Grella G. Guigue M. Gumplinger P. Hadley D.R. Harada M., Hartfiel B., Hartz M., Hassani S., Hastings N.C., Hayato Y., Hernando-Morata J.A., Herrero V., Hill J., Hiraide K., Hirota S., Holin A., Horiuchi S., Hoshina K., Hultqvist K., Iacob F., Ichikawa A.K., Idrissi Ibnsalih W., Iijima T., Ikeda M., Inomoto M., Inoue K., Insler J., Ioannisian A., Ishida T., Ishidoshiro K., Ishino H., Ishitsuka M., Ito H., Ito S., Itow Y., Iwamoto K., Izmaylov A., Izumi N., Izumiyama S., Jakkapu M., Jamieson B., Jang H.I., Jang J.S., Jenkins S.J., Jeon S.H., Jiang M., Jo H.S., Jonsson P., Joo K.K., Kajita T., Kakuno H., Kameda J., Kano Y., Kalaczynski P., Karlen D., Kasperek J., Kataoka Y., Kato A., Katori T., Kazarian N., Kearns E., Khabibullin M., Khotjantsev A., Kikawa T., Kekic M., Kim J.H., Kim J.Y., Kim S.B., Kim S.Y., King S., Kinoshita T., Kisiel Jan, Klekotko A., Kobayashi T., Koch L., Koga M., Koerich L., Kolev N., Konaka A., Kormos L.L., Koshio Y., Korzenev A., Kotsar Y., Kouzakov K.A., Kowalik K.L., Kravchuk L., Kryukov A.P., Kudenko Y., Kumita T., Kurjata R., Kutter T., Kuze M., Kwak K., La Commara M., Labarga L., Lagoda J., Lamers James J., Lamoureux M., Laveder M., Lavitola L., Lawe M., Learned J.G., Lee J., Leitner R., Lezaun V., Lim I.T., Lindner T., Litchfield R.P., Long K.R., Longhin A., Loverre P., Lu X., Ludovici L., Maekawa Y., Magaletti L., Magar K., Mahn K., Makida Y., Malek M., Malinský M., Marchi T., Maret L., Mariani C., Marinelli A., Martens K., Marti L., Martin J.F. Martin D., Marzec J., Matsubara T., Matsumoto R., Matsuno S., Matusiak M., Mazzucato E., McCarthy M., McCauley N., McElwee J., McGrew C., Mefodiev A., Medhi A., Mehta P., Mellet L., Menjo H., Mermod P., Metelko C., Mezzetto M., Migenda J., Migliozzi P., Mijakowski P., Miki S., Miller E.W., Minakata H., Minamino A., Mine S., Mineev O., Mitra A., Miura M., Moharana R., Mollo C.M., Mondal T., Mongelli M., Monrabal F., Moon D.H., Moon C.S., Mora F.J., Moriyama S., Mueller Th.A., Munteanu L., Murase K., Nagao Y., Nakadaira T., Nakagiri K., Nakahata M., Nakai S., Nakajima Y., Nakamura K., Nakamura KI., Nakamura H., Nakano Y., Nakaya T., Nakayama S., Nakayoshi K., Nascimento Machado L., Naseby C.E.R., Navarro-Garcia B., Needham M., Nicholls T., Niewczas K., Nishimura Y., Noah E., Nova F., Nugent J.C., Nunokawa H., Obrebski W., Ochoa-Ricoux J.P., O’Connor E., Ogawa N., Ogitsu T., Ohta K., Okamoto K., O’Keeffe H.M., Okumura K., Onishchuk Y., Orozco-Luna F., Oshlianskyi A., Ospina N., Ostrowski M., O’Sullivan E., O’Sullivan L., Ovsiannikova T., Oyama Y., Ozaki H., Pac M.Y., Paganini P., Palladino V., Paolone V., Pari M., Parsa S., Pasternak J., Pastore C., Pastuszak G., Patel D.A., Pavin M., Payne D., Peña-Garay C., Pidcott C., Pinzon Guerra E., Playfer S., Pointon B.W., Popov A., Popov B., Porwit Kamil, Posiadala-Zezula M., Poutissou J.M., Pozimski J., Pronost G., Prouse N.W., Przewlocki P., Quilain B., Quiroga A.A., Radicioni E., Radics B., Rajda P.J., Renner J., Rescigno M., Retiere F., Ricciardi G., Riccio C., Richards B., Rondio E., Rose H.J., Roskovec B., Roth S., Rott C., Rountree S.D., Rubbia A., Ruggeri A.C., Ruggles C., Russo S., Rychter A., Ryu D., Sakashita K., Samani S., Sánchez F., Sánchez M.L., Sanchez M.C., Sano S., Santos J.D., Santucci G., Sarmah P., Sashima I., Sato K., Scott M., Seiya Y., Sekiguchi T., Sekiya H., Seo J.W., Seo S.H., Sgalaberna D., Shaikhiev A., Shan Z., Shaykina A., Shimizu I., Shin C.D., Shinoki M., Shiozawa M., Sinnis G., Skrobova N., Skwarczynski K., Smy M.B., Sobczyk J., Sobel H.W., Soler F. J. P., Sonoda Y., Spina R., Spisso B., Spradlin B., Stankevich K.L., Stawarz L., Stellacci S.M., Stopa K., Studenikin A.I., Suárez Gómez S.L., Suganuma T., Suvorov S., Suwa Y., Suzuki A.T., Suzuki S.Y., Suzuki Y., Svirida D., Svoboda R., Taani M., Tada M., Takeda A., Takemoto Y., Takenaka A., Taketa A., Takeuchi Y., Takhistov V., Tanaka H., Tanaka H.A., Tanaka H.I., Tanaka M., Tashiro T., Thiesse M., Thompson L.F., Toledo J., Tomatani-Sánchez A.K., Tortone G., Tsui K.M., Tsukamoto T., Tzanov M., Uchida Y., Vagins M.R., Valder S., Valentino V., Vasseur G., Vijayvargi A., Vilela C., Vinning W. G. S., Vivolo D., Vladisavljevic T., Vogelaar R.B., Vyalkov M.M., Wachala T., Walker J., Wark D., Wascko M.O., Wendell R.A., Wilkes R.J., Wilking M.J., Wilson M.R., Wronka S., Xia J., Xie Z., Xin T., Yamaguchi Y., Yamamoto K., Yanagisawa C., Yano T., Yen S., Yershov N., Yeum D.N., Yokoyama M., Yonenaga M., Yoo J., Yu I., Yu M., Zakrzewski T., Zaldivar B., Zalipska J., Zaremba K., Zarnecki G., Ziembicki M., Zietara K., Zito M., Zsoldos S., Core-collapse supernovae are among the most magnificent events in the observable universe. They produce many of the chemical elements necessary for life to exist and their remnants-neutron stars and black holes-are interesting astrophysical objects in their own right. However, despite millennia of observations and almost a century of astrophysical study, the explosion mechanism of core-collapse supernovae is not yet well understood. Hyper-Kamiokande is a next-generation neutrino detector that will be able to observe the neutrino flux from the next galactic core-collapse supernova in unprecedented detail. We focus on the first 500 ms of the neutrino burst, corresponding to the accretion phase, and use a newly-developed, high-precision supernova event generator to simulate Hyper-Kamiokandeʼs response to five different supernova models. We show that Hyper-Kamiokande will be able to distinguish between these models with high accuracy for a supernova at a distance of up to 100 kpc. Once the next galactic supernova happens, this ability will be a powerful tool for guiding simulations toward a precise reproduction of the explosion mechanism observed in nature.
Published: 2022
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13. Impact of Pre-Existing Mitral Regurgitation Following Left Ventricular Assist Device Implant

Author: Christopher M. Sciortino, Kristen M. Ruppert, Brian R. Pierce, William E. Katz, Garrett N. Coyan, Zachary J. Rhinehart, Arman Kilic, and Robert L. Kormos
Subjects: Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, Aftercare, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, otorhinolaryngologic diseases, Clinical endpoint, Humans, Medicine, Retrospective Studies, Intra-aortic balloon pump, Heart Failure, Mitral regurgitation, Ejection fraction, business.industry, technology, industry, and agriculture, Mitral Valve Insufficiency, General Medicine, equipment and supplies, Patient Discharge, respiratory tract diseases, Treatment Outcome, medicine.anatomical_structure, 030228 respiratory system, Ventricular assist device, Vascular resistance, Cardiology, Surgery, Heart-Assist Devices, Implant, Transthoracic echocardiogram, Cardiology and Cardiovascular Medicine, business
Abstract: Objectives: Optimal management of significant mitral regurgitation (SMR) during left ventricular assist device (LVAD) placement remains uncertain. This study evaluates the effect of untreated preop SMR on outcomes following LVAD implant. Methods: Adults undergoing primary LVAD placement from April 2004 to May 2017 were included. Most recent preop transthoracic echocardiogram (TTE) was used to divide patients into an SMR group with moderate or greater regurgitation, and a group without SMR. Patients underwent LVAD implant without correction of SMR. Primary endpoint was 3-year postoperative survival, with secondary endpoints of length of stay (LOS), resolution of SMR following LVAD on postdischarge (30 day) TTE, and 1-year TTE. Results: LVAD placement was performed in 270 patients, 172 (63.7%) without SMR and 98 (36.3%) with SMR. There were no differences in comorbidities including diabetes, hypertension, and renal disease. Preop ejection fraction was similar, but a higher pulmonary vascular resistance was recorded in the SMR group (3.6 vs 3.0 Wood Units, P = 0.048). There was no difference in 3-year mortality between the 2 cohorts (log-rank P = 0.0.803). The SMR group had decreased LOS (median 19.5 vs 22 days, P = 0.009). Of the 98 SMR patients, 91 (92.9%) had resolution of SMR to less than moderate at 30 days. At 1 year, 15% of those with preoperative SMR had recurrent SMR. Conclusions: Patients undergoing LVAD placement with preop SMR experience no differences in mortality, and a majority experience resolution of MR after implant. Longer-term SMR recurrence and need for mitral intervention with LVAD implant warrant further investigation.
Published: 2021
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14. Improved search for invisible modes of nucleon decay in water with the SNO+ detector

Author: SNO+ Collaboration, A. Allega, M. R. Anderson, S. Andringa, M. Askins, D. J. Auty, A. Bacon, N. Barros, F. Barão, R. Bayes, E. W. Beier, T. S. Bezerra, A. Bialek, S. D. Biller, E. Blucher, E. Caden, E. J. Callaghan, S. Cheng, M. Chen, O. Chkvorets, B. Cleveland, D. Cookman, J. Corning, M. A. Cox, R. Dehghani, C. Deluce, M. M. Depatie, J. Dittmer, K. H. Dixon, F. Di Lodovico, E. Falk, N. Fatemighomi, R. Ford, K. Frankiewicz, A. Gaur, O. I. González-Reina, D. Gooding, C. Grant, J. Grove, A. L. Hallin, D. Hallman, J. Hartnell, W. J. Heintzelman, R. L. Helmer, J. Hu, R. Hunt-Stokes, S. M. A. Hussain, A. S. Inácio, C. J. Jillings, T. Kaptanoglu, P. Khaghani, H. Khan, J. R. Klein, L. L. Kormos, B. Krar, C. Kraus, C. B. Krauss, T. Kroupová, I. Lam, B. J. Land, I. Lawson, L. Lebanowski, J. Lee, C. Lefebvre, J. Lidgard, Y. H. Lin, V. Lozza, M. Luo, A. Maio, S. Manecki, J. Maneira, R. D. Martin, N. McCauley, A. B. McDonald, M. Meyer, C. Mills, I. Morton-Blake, S. Naugle, L. J. Nolan, H. M. O'Keeffe, G. D. Orebi Gann, J. Page, W. Parker, J. Paton, S. J. M. Peeters, L. Pickard, P. Ravi, A. Reichold, S. Riccetto, R. Richardson, M. Rigan, J. Rose, J. Rumleskie, I. Semenec, P. Skensved, M. Smiley, R. Svoboda, B. Tam, J. Tseng, E. Turner, S. Valder, J. G. C. Veinot, C. J. Virtue, E. Vázquez-Jáuregui, J. Wang, M. Ward, J. J. Weigand, J. D. Wilson, J. R. Wilson, A. Wright, J. P. Yanez, S. Yang, M. Yeh, S. Yu, T. Zhang, Y. Zhang, K. Zuber, and A. Zummo
Subjects: High Energy Physics - Experiment (hep-ex), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, High Energy Physics - Experiment
Abstract: This paper reports results from a search for single and multinucleon disappearance from the O16 nucleus in water within the SNO+ detector using all of the available data. These so-called “invisible” decays do not directly deposit energy within the detector but are instead detected through their subsequent nuclear deexcitation and gamma-ray emission. New limits are given for the partial lifetimes: τ(n→inv)>9.0×1029 years, τ(p→inv)>9.6×1029 years, τ(nn→inv)>1.5×1028 years, τ(np→inv)>6.0×1028 years, and τ(pp→inv)>1.1×1029 years at 90% Bayesian credibility level (with a prior uniform in rate). All but the (nn→inv) results improve on existing limits by a factor of about 3.
Published: 2022
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15. Correction: Understanding and Addressing Variation in Health Care–Associated Infections After Durable Ventricular Assist Device Therapy: Protocol for a Mixed Methods Study (Preprint)

Author: P Paul Chandanabhumma, Michael D Fetters, Francis D Pagani, Preeti N Malani, John M Hollingsworth, Russell J Funk, Keith D Aaronson, Min Zhang, Robert L Kormos, Carol E Chenoweth, Supriya Shore, Tessa M F Watt, Lourdes Cabrera, and Donald S Likosky
Abstract: UNSTRUCTURED This is a corrigendum of original article ms# 14701.
Published: 2022
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16. Outcomes With Phosphodiesterase-5 Inhibitor Use After Left Ventricular Assist Device: An STS-INTERMACS Analysis

Author: E. Wilson Grandin, Gaurav Gulati, Jose I. Nunez, Kevin Kennedy, J. Eduardo Rame, Pavan Atluri, Francis D. Pagani, James K. Kirklin, Robert L. Kormos, Jeffrey Teuteberg, and Michael S. Kiernan
Subjects: Adult, Cyclic Nucleotide Phosphodiesterases, Type 5, Heart Failure, Phosphodiesterase Inhibitors, Heart Ventricles, Ventricular Dysfunction, Right, Phosphodiesterase 5 Inhibitors, Article, Treatment Outcome, Heart Transplantation, Humans, Registries, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, Retrospective Studies
Abstract: Background: Elevated right ventricular afterload following continuous-flow left ventricular assist device (CF-LVAD) may contribute to late right heart failure (LRHF). PDE5i (phosphodiesterase-5 inhibitors) are used to treat pulmonary hypertension and right heart dysfunction after CF-LVAD, but their impact on outcomes is uncertain. Methods: We queried Interagency Registry for Mechanically Assisted Circulatory Support from 2012 to 2017 for adults receiving a primary CF-LVAD and surviving ≥30 days from index discharge. Patients receiving early PDE5i (ePDE5i) at 1 month were propensity-matched 1:1 with controls. The primary outcome was the cumulative incidence of LRHF, defined using prevailing Interagency Registry for Mechanically Assisted Circulatory Support criteria; secondary outcomes included all-cause mortality and major bleeding. Results: Among 9627 CF-LVAD recipients analyzed, 2463 (25.6%) received ePDE5i and 1600 were propensity-matched 1:1 with controls. Before implant, ePDE5i patients had more severe RV dysfunction (13.1% versus 9.6%) and higher pulmonary vascular resistance (2.8±2.7 versus 2.2±2.4 WU), both P P =0.07); mortality 38.6% versus 35.8% (hazard ratio, 0.99 [95% CI, 0.86–1.15]; P =0.93); major bleeding 51.2% versus 46.0% (hazard ratio, 1.12 [95% CI, 0.99–1.27]; P =0.06). Conclusions: Compared with propensity-matched controls, adult CF-LVAD patients receiving ePDE5i had similar rates of LRHF, mortality, and major bleeding. While intrinsic patient risk factors likely account for more adverse outcomes with ePDE5i in the unmatched cohort, there is no obvious benefit of ePDE5i in the LVAD population.
Published: 2022
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17. Prognosis of Right Ventricular Failure in Patients With Left Ventricular Assist Device Based on Decision Tree With SMOTE.

Author: Yajuan Wang, Marc A. Simon, Pramod Bonde, Bronwyn U. Harris, Jeffrey J. Teuteberg, Robert L. Kormos, and James F. Antaki
Published: 2012
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18. Current Status and Future Prospects of the SNO+ Experiment

Author: S. Andringa, E. Arushanova, S. Asahi, M. Askins, D. J. Auty, A. R. Back, Z. Barnard, N. Barros, E. W. Beier, A. Bialek, S. D. Biller, E. Blucher, R. Bonventre, D. Braid, E. Caden, E. Callaghan, J. Caravaca, J. Carvalho, L. Cavalli, D. Chauhan, M. Chen, O. Chkvorets, K. Clark, B. Cleveland, I. T. Coulter, D. Cressy, X. Dai, C. Darrach, B. Davis-Purcell, R. Deen, M. M. Depatie, F. Descamps, F. Di Lodovico, N. Duhaime, F. Duncan, J. Dunger, E. Falk, N. Fatemighomi, R. Ford, P. Gorel, C. Grant, S. Grullon, E. Guillian, A. L. Hallin, D. Hallman, S. Hans, J. Hartnell, P. Harvey, M. Hedayatipour, W. J. Heintzelman, R. L. Helmer, B. Hreljac, J. Hu, T. Iida, C. M. Jackson, N. A. Jelley, C. Jillings, C. Jones, P. G. Jones, K. Kamdin, T. Kaptanoglu, J. Kaspar, P. Keener, P. Khaghani, L. Kippenbrock, J. R. Klein, R. Knapik, J. N. Kofron, L. L. Kormos, S. Korte, C. Kraus, C. B. Krauss, K. Labe, I. Lam, C. Lan, B. J. Land, S. Langrock, A. LaTorre, I. Lawson, G. M. Lefeuvre, E. J. Leming, J. Lidgard, X. Liu, Y. Liu, V. Lozza, S. Maguire, A. Maio, K. Majumdar, S. Manecki, J. Maneira, E. Marzec, A. Mastbaum, N. McCauley, A. B. McDonald, J. E. McMillan, P. Mekarski, C. Miller, Y. Mohan, E. Mony, M. J. Mottram, V. Novikov, H. M. O’Keeffe, E. O’Sullivan, G. D. Orebi Gann, M. J. Parnell, S. J. M. Peeters, T. Pershing, Z. Petriw, G. Prior, J. C. Prouty, S. Quirk, A. Reichold, A. Robertson, J. Rose, R. Rosero, P. M. Rost, J. Rumleskie, M. A. Schumaker, M. H. Schwendener, D. Scislowski, J. Secrest, M. Seddighin, L. Segui, S. Seibert, T. Shantz, T. M. Shokair, L. Sibley, J. R. Sinclair, K. Singh, P. Skensved, A. Sörensen, T. Sonley, R. Stainforth, M. Strait, M. I. Stringer, R. Svoboda, J. Tatar, L. Tian, N. Tolich, J. Tseng, H. W. C. Tseung, R. Van Berg, E. Vázquez-Jáuregui, C. Virtue, B. von Krosigk, J. M. G. Walker, M. Walker, O. Wasalski, J. Waterfield, R. F. White, J. R. Wilson, T. J. Winchester, A. Wright, M. Yeh, T. Zhao, and K. Zuber
Subjects: Physics, QC1-999
Abstract: SNO+ is a large liquid scintillator-based experiment located 2 km underground at SNOLAB, Sudbury, Canada. It reuses the Sudbury Neutrino Observatory detector, consisting of a 12 m diameter acrylic vessel which will be filled with about 780 tonnes of ultra-pure liquid scintillator. Designed as a multipurpose neutrino experiment, the primary goal of SNO+ is a search for the neutrinoless double-beta decay (0νββ) of 130Te. In Phase I, the detector will be loaded with 0.3% natural tellurium, corresponding to nearly 800 kg of 130Te, with an expected effective Majorana neutrino mass sensitivity in the region of 55–133 meV, just above the inverted mass hierarchy. Recently, the possibility of deploying up to ten times more natural tellurium has been investigated, which would enable SNO+ to achieve sensitivity deep into the parameter space for the inverted neutrino mass hierarchy in the future. Additionally, SNO+ aims to measure reactor antineutrino oscillations, low energy solar neutrinos, and geoneutrinos, to be sensitive to supernova neutrinos, and to search for exotic physics. A first phase with the detector filled with water will begin soon, with the scintillator phase expected to start after a few months of water data taking. The 0νββ Phase I is foreseen for 2017.
Published: 2016
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19. Gender Differences in Mortality After Left Ventricular Assist Device Implant: A Causal Mediation Analysis Approach

Author: Anurag Mehta, Yi-An Ko, Alanna A. Morris, Rongbing Xie, Aditi Nayak, Marc A. Simon, Robert L. Kormos, Jennifer A Cowger, Chang Liu, John Pennington, Yingtian Hu, and James K. Kirklin
Subjects: Adult, Male, medicine.medical_specialty, Ventricular Dysfunction, Right, medicine.medical_treatment, Biomedical Engineering, Biophysics, Bioengineering, 030204 cardiovascular system & hematology, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Risk of mortality, Humans, Lung transplantation, Causal mediation, Aged, Proportional Hazards Models, Heart Failure, Sex Characteristics, Mediation Analysis, business.industry, Proportional hazards model, Hazard ratio, General Medicine, Middle Aged, 030228 respiratory system, Ventricular assist device, Circulatory system, Cardiology, Female, Heart-Assist Devices, Implant, business
Abstract: We used the International Society for Heart and Lung Transplantation (ISHLT) Registry for Mechanically Assisted Circulatory Support (IMACS) database to examine 1) gender differences in post-left ventricular assist device (LVAD) mortality in the contemporary era and 2) preimplant clinical factors that might mediate any observed differences. Adults who received continuous-flow (CF)-LVAD from January 2013 to September 2017 (n = 9,565, age: 56.2 ± 13.2 years, 21.6% female, 31.1% centrifugal pumps) were analyzed. An inverse probability weighted Cox proportional hazards model was used to estimate association of female gender with all-cause mortality, adjusting for known covariates. Causal mediation analysis was performed to test plausible preimplant mediators mechanistically underlying any association between female gender and mortality. Females had higher mortality after LVAD (adjusted hazard ratio [HR]: 1.36; p < 0.0001), with significant gender × time interaction (p = 0.02). An early period of increased risk was identified, with females experiencing a higher risk of mortality during the first 4 months after implant (adjusted HR: 1.74; p < 0.0001), but not after (adjusted HR: 1.18; p = 0.16). More severe tricuspid regurgitation and smaller left ventricular end-diastolic diameter at baseline mediated ≈21.9% of the increased early hazard of death in females; however, most of the underlying mechanisms remain unexplained. Therefore, females have increased mortality only in the first 4 months after LVAD implantation, partially driven by worsening right ventricular dysfunction and LV-LVAD size mismatch.
Published: 2020
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20. Evaluation of a Health Care Performance Improvement Initiative to Facilitate Optimal Clinical Outcomes in Patients Receiving Ventricular Assist Device Support

Author: Robert L. Kormos, Donald A. Severyn, Michael McCall, Amanda Pearsol, Douglas Lohmann, Mary Amanda Dew, Brian Morelli, Christopher M. Sciortino, R. Schaub, N. Kunz, Kathleen L. Lockard, E. Dunn, and Jeffrey J. Teuteberg
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, Certification, 030230 surgery, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Health care, Ventricular Dysfunction, medicine, Humans, Prealbumin, In patient, Cardiac Surgical Procedures, Intensive care medicine, Physical Therapy Modalities, Aged, Retrospective Studies, Transplantation, business.industry, Incidence, Length of Stay, Middle Aged, Quality Improvement, United States, Treatment Outcome, Ventricular assist device, Practice Guidelines as Topic, Female, Heart-Assist Devices, Performance improvement, business
Abstract: Background: Ventricular assist device (VAD) patients are at high risk for morbidities and mortality. One potentially beneficial component of the Joint Commission VAD Certification process is the requirement that individual VAD programs select 4 performance measures to improve and optimize patients’ clinical outcomes. Problem Statement: Review of patient data after our program’s first certification visit in 2008 showed that, compared to national recommendations and published reports, our patients had suboptimal outcomes in 4 areas after device implantation: length of hospital stay, receipt of early (Methods: Plan-Do-Study-Act processes were implemented to shorten length of stay, increase patient receipt of early physical therapy, decrease driveline infection incidence, and improve nutritional status. With 2008 as our baseline, we deployed interventions for each outcome area across 2009 to 2017. Performance improvement activities included staff, patient, and family didactic, one-on-one, and hands-on education; procedural changes; and outcomes monitoring with feedback to staff on progress. Descriptive and inferential statistics were examined to document change in the outcomes. Outcomes: Across the performance improvement period, length of stay decreased from 40 to 23 days; physical therapy consults increased from 87% to 100% of patients; 1-year driveline infection incidence went from 38% to 23.5%; and the percentage of patients with prealbumin within the normal range increased from 84% to 90%. Implications: Performance improvement interventions may enhance ventricular assist device patient outcomes. Interventions’ sustainability should be evaluated to ensure that gains are not lost over time.
Published: 2020
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21. Aortic Insufficiency After Left Ventricular Assist Device Implantation: Predictors and Outcomes

Author: Robert L. Kormos, Edgar Aranda-Michel, Hiroshi Kagawa, Yisi Wang, Arman Kilic, Michael A. Mathier, Gavin Hickey, and Mary E. Keebler
Subjects: Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Aortic Valve Insufficiency, Group ii, Treatment outcome, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, medicine, Humans, Survival rate, Retrospective Studies, Heart Failure, business.industry, Incidence, Incidence (epidemiology), Disease progression, Retrospective cohort study, Middle Aged, equipment and supplies, Surgery, Survival Rate, Treatment Outcome, 030228 respiratory system, Echocardiography, Ventricular assist device, Disease Progression, Female, Heart-Assist Devices, Implant, Cardiology and Cardiovascular Medicine, business
Abstract: The aim of this study was to evaluate the incidence, risk factors, and clinical impact of progression of aortic insufficiency (AI) after left ventricular assist device (LVAD) implantation.Patients undergoing primary durable LVAD implantation between 2004 and 2018 were included. Significant AI was defined as more than mild AI. Clinical and echocardiographic data were collected. Patients were stratified by degree of pre-LVAD AI into 3 groups: no AI, group I; trace AI, group II; and mild AI, group III.Three hundred sixteen eligible patients underwent LVAD implant, 229 patients (72.5%) in group I, 54 (17.1%) in group II, and 33 (10.4%) in group III. Median follow-up was 469 days. Forty-two patients (13.3%) progressed to significant AI during follow-up. Group III patients had the highest rate of developing significant AI (I, 10.0%; II, 13.0%; III, 36.4%; P = .002). Freedom from significant AI at 1 year after LVAD implant was 94.5% in group I, 86.1% in group II, and 62.4% in group III (P.001). Predictors of developing significant AI included mild preoperative AI, ischemic cardiomyopathy, and shorter duration of LVAD support. Patients with significant AI after LVAD implantation had higher mortality compared with those without (59.5% vs 37.2%; P = .006).Although some patients supported with an LVAD develop significant AI, this risk is increased in those with mild AI preoperatively. This finding, in conjunction with the increased mortality risk once significant AI develops, suggests that closer follow-up and management of LVAD patients with mild preoperative AI may be prudent.
Published: 2020
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22. The Preimplantation Psychosocial Evaluation and Prediction of Clinical Outcomes During Mechanical Circulatory Support: What Information Is Most Prognostic?

Author: N. Kunz, Dennis M. McNamara, Mary E. Keebler, Kathleen L. Lockard, Robert L. Kormos, Mary Amanda Dew, Gavin Hickey, Ravi Ramani, Michael A. Mathier, Arman Kilic, Laura Liliana Obregon, Jennifer Hollenberger, Christopher M. Sciortino, and Marc A. Simon
Subjects: Heart transplantation, Transplantation, medicine.medical_specialty, business.industry, medicine.medical_treatment, Hazard ratio, MEDLINE, Odds ratio, Mental health, Internal medicine, medicine, business, Psychosocial, Destination therapy
Abstract: Background Psychosocial evaluations are required for long-term mechanical circulatory support (MCS) candidates, no matter whether MCS will be destination therapy (DT) or a bridge to heart transplantation. Although guidelines specify psychosocial contraindications to MCS, there is no comprehensive examination of which psychosocial evaluation domains are most prognostic for clinical outcomes. We evaluated whether overall psychosocial risk, determined across all psychosocial domains, predicted outcomes, and which specific domains appeared responsible for any effects. Methods A single-site retrospective analysis was performed for adults receiving MCS between April 2004 and December 2017. Using an established rating system, we coded psychosocial evaluations to identify patients at low, moderate, or high overall risk. We similarly determined risk within each of 10 individual psychosocial domains. Multivariable analyses evaluated whether psychosocial risk predicted clinical decisions about MCS use (DT versus bridge), and postimplantation mortality, transplantation, rehospitalization, MCS pump exchange, and standardly defined adverse medical events (AEs). Results In 241 MCS recipients, greater overall psychosocial risk increased the likelihood of a DT decision (odds ratio, 1.76; P = 0.017); and postimplantation pump exchange and occurrence of AEs (hazard ratios [HRs] ≥ 1.25; P ≤ 0.042). The individual AEs most strongly predicted were cardiac arrhythmias and device malfunctions (HRs ≥ 1.39; P ≤ 0.032). The specific psychosocial domains predicting at least 1 study outcome were mental health problem severity, poorer medical adherence, and substance use (odds ratios and HRs ≥ 1.32; P ≤ 0.010). Conclusions The psychosocial evaluation predicts not only clinical decisions about MCS use (DT versus bridge) but important postimplantation outcomes. Strategies to address psychosocial risk factors before or soon after implantation may help to reduce postimplantation clinical risks.
Published: 2020
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23. Challenges in the development and implementation of a healthcare system based extracorporeal cardiopulmonary resuscitation (ECPR) program for the treatment of out of hospital cardiac arrest

Author: Christopher M. Sciortino, Meshe Chonde, Penny L. Sappington, Anson J. Conrad Smith, Frank X Guyette, Mark Schmidhofer, Jeremiah Escajeda, Jonathan Elmer, Robert L. Kormos, Arthur J. Boujoukos, and Clifton W. Callaway
Subjects: Adult, Emergency Medical Services, medicine.medical_specialty, Adolescent, 030204 cardiovascular system & hematology, Emergency Nursing, Out of hospital cardiac arrest, Young Adult, 03 medical and health sciences, Extracorporeal Membrane Oxygenation, 0302 clinical medicine, Emergency medical services, Humans, Medicine, Extracorporeal cardiopulmonary resuscitation, High probability, business.industry, 030208 emergency & critical care medicine, Shockable rhythm, EMS dispatch, Middle Aged, Cardiopulmonary Resuscitation, Checklist, Emergency medicine, Emergency Medicine, Cardiology and Cardiovascular Medicine, business, Delivery of Health Care, Out-of-Hospital Cardiac Arrest, Healthcare system
Abstract: Introduction Extracorporeal cardiopulmonary resuscitation (ECPR) can treat cardiac arrest refractory to conventional therapies. Many institutions are interested in developing their own ECPR program. However, there may be challenges in logistics and implementation. Aims The aim of our protocol was to demonstrate that an ECPR team was feasible within our healthcare system and that the identification of UPMC Presbyterian as a receiving center allowed for successful treatment within 30 min from EMS dispatch. Methods We developed out of hospital cardiac arrest (OHCA) ECPR protocols for Emergency Medical Services (EMS), EMS communications, and our in-hospital ECPR team. Inclusion criteria indentified patients with a potentially reversible arrest etiology and high probability of recoverable brain injury using a simple checklist: witnessed collapse, layperson CPR, initial shockable rhythm, and age 18–60 years. We trained local EMS crews to screen patients and reviewed the criteria with a Medic Command Physician prior to transport to our hospital. Results From October 2015 to March 31st 2018, EMS treated 1165 EMS OHCA cases, transported 664 (57%) to a local hospital, and transported 120 (10%) to our institution. Of these, five (4.1%) patients underwent ECPR. Among excluded cases, 64 (53%) had nonshockable rhythms, 48 (40%) were unwitnessed arrests, 50 (42%) were over age 60 and the remaining 20 (17%) had no documented reasons for exclusion. For ECPR cases, median pre-hospital CPR duration was 26 [IQR 25–40] min. Four patients (80%) received mechanical CPR. Interval from arrest to arrival on scene was 5 [IQR 4–6] min and interval from radio call to activation of ECPR was 13 [IQR 7–21] min. Interval from EMS dispatch to departure from scene was 20 [IQR 19–21] min. Time from EMS dispatch to initiation of ECPR was 63 [IQR 59–69] min. Conclusions ECPR is an infrequent occurrence in EMS practice. Most apparently eligible patients did not get ECPR, highlighting the need for ongoing programmatic development, provider education, and qualitative work exploring barriers to implementation.
Published: 2020
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24. Updated definitions of adverse events for trials and registries of mechanical circulatory support: A consensus statement of the mechanical circulatory support academic research consortium

Author: Christiaan F J Antonides, Paul Mohacsi, Josef Stehlik, J. Eduardo Rame, Mark S. Slaughter, Francis D. Pagani, Steve C. Koenig, Heinrich Schima, Vivek Rao, Evgenij V. Potapov, Robert L. Kormos, David N. Rosenthal, Kadir Caliskan, Steven R. Messé, Jeffrey J. Teuteberg, Daniel J. Goldstein, Jennifer A Cowger, James K. Kirklin, Susan M. Joseph, Martha L. Mooney, Randall C. Starling, Cardiothoracic Surgery, and Cardiology
Subjects: Heart Failure, Pulmonary and Respiratory Medicine, Clinical Trials as Topic, Transplantation, medicine.medical_specialty, Consensus, business.industry, Statement (logic), MEDLINE, Humans, Medicine, Surgery, Heart-Assist Devices, Registries, Cardiology and Cardiovascular Medicine, business, Intensive care medicine, Adverse effect
Published: 2020
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25. Center Variability in Patient Outcomes Following HeartMate 3 Implantation: An Analysis of the MOMENTUM 3 Trial

Author: MANREET K. Kanwar, FRANCIS D. PAGANI, MANDEEP R. MEHRA, JERRY D. ESTEP, SEAN P. PINNEY, SCOTT C. SILVESTRY, NIR URIEL, DANIEL J. GOLDSTEIN, JAMES LONG, JOSEPH C. CLEVELAND, ROBERT L. KORMOS, AIJIA WANG, JOYCE CHUANG, and JENNIFER A. COWGER
Subjects: Heart Failure, Male, Survival Rate, Treatment Outcome, Humans, Female, Heart-Assist Devices, Cardiology and Cardiovascular Medicine
Abstract: As left ventricular assist device (LVAD) survival rates continue to improve, evaluating site-specific variability in outcomes can facilitate identifying targets for quality-improvement initiative opportunities in the field.Deidentified center-specific outcomes were analyzed for HeartMate 3 (HM3) patients enrolled in the MOMENTUM 3 pivotal and continued access protocol trials. Centers25th percentile for HM3 volumes were excluded. Variability in risk-adjusted center mortality was assessed at 90 days and 2 years (conditional upon 90-day survival). Adverse event (AE) rates were compared across centers.In the 48 included centers (1958 patients), study-implant volumes ranged between 17 and 106 HM3s. Despite similar trial-inclusion criteria, patient demographics varied across sites, including age quartile ((Q)1-Q3:57-62 years), sex (73%-85% male), destination therapy intent (60%-84%), and INTERMACS profile 1-2 (16%-48%). Center mortality was highly variable, nadiring at ≤ 3.6% (≤ 25th percentile) and peaking at ≥ 10.4% (≥ 75th percentile) at 90 days and ≤ 10.2% and ≥ 18.7%, respectively, at 2 years. Centers with low mortality rates tended to have lower 2-year AE rates, but no center was a top performer for all AEs studied.Mortality and AEs were highly variable across MOMENTUM 3 centers. Studies are needed to improve our understanding of the drivers of outcome variability and to ascertain best practices associated with high-performing centers across the continuum of intraoperative to chronic stages of LVAD support.
Published: 2022

26. Special Considerations for Durable Left Ventricular Assist Device Use in Small Patients

Author: Kevin Bourque, Catherine E. Fraser, Angela Lorts, Ezequiel J. Molina, Robert L. Kormos, Yoshifumi Naka, Farooq H. Sheikh, Nir Y. Uriel, and David L.S. Morales
Subjects: Biomaterials, Heart Failure, Treatment Outcome, Biomedical Engineering, Biophysics, Humans, Bioengineering, General Medicine, Heart-Assist Devices, Ventricular Function, Left, Retrospective Studies
Published: 2022

27. Hospitalization Patterns and Impact of a Magnetically-Levitated Left Ventricular Assist Device in the MOMENTUM 3 Trial

Author: Himabindu Vidula, Koji Takeda, Jerry D. Estep, Scott C. Silvestry, Carmelo Milano, Joseph C. Cleveland, Daniel J. Goldstein, Nir Uriel, Robert L. Kormos, Nicholas Dirckx, and Mandeep R. Mehra
Subjects: Heart Failure, Hospitalization, Male, Time Factors, Treatment Outcome, Humans, Heart-Assist Devices, Cardiology and Cardiovascular Medicine
Abstract: In the MOMENTUM 3 (Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3) pivotal trial, the HeartMate 3 (HM3) fully magnetically levitated left ventricular assist device (LVAD) demonstrated superiority over the axial-flow HeartMate II (HMII) LVAD. The patterns and predictors of hospitalizations with the HM3 LVAD have not been characterized.This study sought to determine causes, predictors, and impact of hospitalizations during LVAD support.Patients discharged after LVAD implantation were analyzed. In the pivotal trial, 485 recipients of HM3 were compared with 471 recipients of HMII. The pivotal trial HM3 group was also compared to 949 recipients of HM3 in the postapproval phase within the trial portfolio. Predictors of cause-specific rehospitalization were analyzed.The rates of rehospitalization were lower with HM3 LVAD than with HMII LVAD in the pivotal trial (225.7 vs 246.4 events per 100 patient-years; P 0.05). Overall, rehospitalization rates and duration were similar in the HM3 postapproval phase and pivotal trial but prolonged hospitalizations (7 days) were less frequent (rate ratio: 0.90 [95% CI: 0.80-0.98]; P 0.05). In HM3 recipients, the most frequent causes of rehospitalization included infection, heart failure (HF)-related events, and bleeding. First rehospitalization caused by HF-related event versus other causes was associated with reduced survival (HR: 2.2 [95% CI: 1.3-3.9]; P = 0.0014). Male sex, non-White race, presence of cardiac resynchronization therapy/implantable cardioverter-defibrillator, obesity, higher right atrial pressure, smaller LV size, longer duration of index hospitalization, and lower estimated glomerular filtration rate at index discharge predicted HF hospitalizations.Contemporary support with the HM3 fully magnetically levitated LVAD is associated with a lower hospitalization burden than with prior pumps; however, rehospitalizations for infection, HF, and bleeding remain important challenges for progress in the patient journey. (MOMENTUM 3 IDE Clinical Study, NCT02224755; MOMENTUM 3 Continued Access Protocol [MOMENTUM 3 CAP], NCT02892955).
Published: 2022

28. Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors

Author: Shenping Liu, Bethany L. Kormos, John D. Knafels, Parag V. Sahasrabudhe, Amy Rosado, Ruth F. Sommese, Allan R. Reyes, Jessica Ward, Rachel J. Roth Flach, Xiaochun Wang, Leanne M. Buzon, Matthew R. Reese, Samit K. Bhattacharya, Kiyoyuki Omoto, and Kevin J. Filipski
Subjects: Cell Biology, Molecular Biology, Biochemistry
Published: 2023
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29. Primary Graft Dysfunction in Heart Transplant Recipients-Risk Factors and Longitudinal Outcomes

Author: Gavin Hickey, Michael V. Genuardi, Robert L. Kormos, Arman Kilic, Sina Salehi Omran, Edward T. Horn, Mary E. Keebler, Christopher M. Sciortino, and Nicholas F. Smith
Subjects: Inotrope, Adult, medicine.medical_specialty, medicine.medical_treatment, Biomedical Engineering, Biophysics, Primary Graft Dysfunction, Bioengineering, Amiodarone, Logistic regression, Biomaterials, Risk Factors, Internal medicine, medicine, Lung transplantation, Humans, Retrospective Studies, business.industry, Incidence (epidemiology), General Medicine, Perioperative, respiratory system, Transplant Recipients, Heart Transplantation, lipids (amino acids, peptides, and proteins), business, Body mass index, medicine.drug, Lung Transplantation
Abstract: Before the 33rd Annual International Society for Heart and Lung Transplantation conference, there was significant intercenter variability in definitions of primary graft dysfunction (PGD). The incidence, risk factors, and outcomes of consensus-defined PGD warrant further investigation. We retrospectively examined 448 adult cardiac transplant recipients at our institution from 2005 to 2017. Patient and procedural characteristics were compared between PGD cases and controls. Multivariable logistic regression was used to model PGD and immediate postoperative high-inotrope requirement for hypothesized risk factors. Patients were followed for a mean 5.3 years to determine longitudinal mortality. The incidence of PGD was 16.5%. No significant differences were found with respect to age, sex, race, body mass index, predicted heart mass mismatch, pretransplant amiodarone therapy, or pretransplant mechanical circulatory support (MCS) between recipients with PGD versus no PGD. Each 10 minute increase in ischemic time was associated with 5% greater odds of PGD (OR = 1.05 [95% CI, 1.00-1.10]; p = 0.049). Pretransplant MCS, predicted heart mass mismatch ≥30%, and pretransplant amiodarone therapy were associated with high-immediate postoperative inotropic requirement. The 30 day, 1 year, and 5 year mortality for patients with PGD were 28.4%, 38.0%, and 45.8%, respectively, compared with 1.9%, 7.1%, and 21.5% for those without PGD (log-rank, p < 0.0001). PGD heralded high 30 day, 1 year, and 5 year mortality. Pretransplant MCS, predicted heart mass mismatch, and amiodarone exposure were associated with high-inotrope requirement, while prolonged ischemic time and multiple perioperative transfusions were associated with consensus-defined PGD, which may have important clinical implications under the revised United Network for Organ Sharing allocation system.
Published: 2021

30. Artificial Lungs: Current Status and Future Directions

Author: Arturo J. Cardounel, Robert L. Kormos, Ryan A. Orizondo, and Pablo G. Sanchez
Subjects: Transplantation, Hepatology, business.industry, medicine.medical_treatment, Immunology, respiratory system, 030230 surgery, Wearable systems, Artificial lung, 03 medical and health sciences, 0302 clinical medicine, Risk analysis (engineering), Nephrology, Proof of concept, Lung disease, Biomimetic Devices, Medicine, Lung transplantation, 030211 gastroenterology & hepatology, Surgery, business, Destination therapy
Abstract: Although lung transplantation can be used to treat lung failure, limited donor organ availability creates a pressing need for improved artificial lung technology. This review discusses recent developments and future research pathways for respiratory assist devices and regenerative therapies intended to treat advanced lung disease. Hollow fiber membrane gas exchangers can be used to bridge lung failure patients to transplantation. Engineering improvements to such devices are on the verge of enabling longer term wearable systems that simplify and improve support. Progress with microchannel-based devices provides hope of smaller, more biomimetic devices that may even enable implantation; however, further development and testing are needed. Advances in cell-based technologies and tissue engineering have enabled early proof of concept of bioartificial lungs with properties similar to the native organ. Recent progress with artificial lungs has enabled better treatment as a bridge therapy. Continued advances in both engineering and biology will be necessary to achieve a truly implantable artificial lung capable of destination therapy.
Published: 2019
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31. Risk Assessment in Patients with a Left Ventricular Assist Device Across INTERMACS Profiles Using Bayesian Analysis

Author: Jeffrey J. Teuteberg, James F. Antaki, Manreet Kanwar, Colleen K. McIlvennan, Srinivas Murali, Stephen H. Bailey, Lisa C. Lohmueller, Raymond L. Benza, JoAnn Lindenfeld, Joseph G. Rogers, and Robert L. Kormos
Subjects: Male, medicine.medical_specialty, Databases, Factual, Heart Ventricles, International Cooperation, medicine.medical_treatment, Biomedical Engineering, Biophysics, Bioengineering, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Risk Assessment, Article, Biomaterials, 03 medical and health sciences, Bayes' theorem, 0302 clinical medicine, Internal medicine, medicine, Risk of mortality, Humans, Registries, Retrospective Studies, Heart Failure, Receiver operating characteristic, business.industry, Area under the curve, Bayes Theorem, Retrospective cohort study, Equipment Design, General Medicine, Middle Aged, United States, ROC Curve, 030228 respiratory system, Area Under Curve, Ventricular assist device, Cardiology, Female, Heart-Assist Devices, Risk assessment, business, Algorithms, Destination therapy
Abstract: Current risk stratification models to predict outcomes after a left ventricular assist device (LVAD) are limited in scope. We assessed the performance of Bayesian models to stratify post-LVAD mortality across various International Registry for Mechanically Assisted Circulatory Support (INTERMACS or IM) Profiles, device types, and implant strategies. We performed a retrospective analysis of 10,206 LVAD patients recorded in the IM registry from 2012 to 2016. Using derived Bayesian algorithms from 8,222 patients (derivation cohort), we applied the risk-prediction algorithms to the remaining 2,055 patients (validation cohort). Risk of mortality was assessed at 1, 3, and 12 months post implant according to disease severity (IM profiles), device type (axial versus centrifugal) and strategy (bridge to transplantation or destination therapy). Fifteen percentage (n = 308) were categorized as IM profile 1, 36% (n = 752) as profile 2, 33% (n = 672) as profile 3, and 15% (n = 311) as profile 4-7 in the validation cohort. The Bayesian algorithms showed good discrimination for both short-term (1 and 3 months) and long-term (1 year) mortality for patients with severe HF (Profiles 1-3), with the receiver operating characteristic area under the curve (AUC) between 0.63 and 0.74. The algorithms performed reasonably well in both axial and centrifugal devices (AUC, 0.68-0.74), as well as bridge to transplantation or destination therapy indication (AUC, 0.66-0.73). The performance of the Bayesian models at 1 year was superior to the existing risk models. Bayesian algorithms allow for risk stratification after LVAD implantation across different IM profiles, device types, and implant strategies.
Published: 2019
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32. First T2K measurement of transverse kinematic imbalance in the muon-neutrino charged-current single- π+ production channel containing at least one proton

Author: T. Arihara, Y. Hayato, J. R. Wilson, L. Ludovici, S. V. Cao, M. Gonin, T. Honjo, S. Moriyama, S. Roth, D. G. Payne, A. Nakamura, W. C. Parker, L. Molina Bueno, R. Zaki, C. E. R. Naseby, G. D. Megias, S. K. Lin, C. Alt, J. Parlone, M. Tzanov, J. Kisiel, K. Matsushita, M. Zito, Hidekazu Kakuno, G. Yang, N. Izumi, A. K. Ichikawa, K. Niewczas, Patrick Dunne, J. Kameda, A. Eguchi, C. Touramanis, Antonio Ereditato, N. Yershov, C. Giganti, S. Kuribayashi, R. Okada, B. Jamieson, A. Zalewska, C. Jesús-Valls, Kevin Scott McFarland, D. Cherdack, S. Valder, K. Abe, S. Suvorov, R. P. Litchfield, P. Hamacher-Baumann, K. Yasutome, A. Shvartsman, N. Teshima, D. Bravo Berguño, G. Pintaudi, Y. Fujii, C. Mauger, S. Manly, Federico Sanchez, C. McGrew, L. Koch, C. Andreopoulos, Masato Shiozawa, S. R. Dennis, C. M. Schloesser, Xianguo Lu, M. J. Wilking, Gareth J. Barker, A. Beloshapkin, A. Takeda, B. A. Popov, D. Vargas, M. Grassi, T. A. Doyle, E. Radicioni, Vincenzo Berardi, D. Barrow, Etam Noah, F. J. P. Soler, Alexander Finch, J. Chakrani, A. Hiramoto, T. Hasegawa, A. Gorin, J. Dumarchez, K. Fusshoeller, R.P. Kurjata, S. P. Kasetti, T. Ogawa, L. Munteanu, M. Tajima, Yusuke Koshio, A. T. Suzuki, Y. Nagai, C. K. Jung, Alan Cosimo Ruggeri, A. Kostin, André Rubbia, T. Matsubara, T. Vladisavljevic, L. Magaletti, S. Bhadra, L. Cook, F. Iacob, L. Berns, Yuuki Nakano, R. Fukuda, D. L. Wark, Y. Tanihara, G. C. Penn, G. Vasseur, Y. Kataoka, Th. A. Mueller, Thorsten Lux, A. Maurel, F. Di Lodovico, M. Hartz, A. Bubak, C. Pistillo, Kate Scholberg, T. Sekiguchi, Y. Asada, M. Tada, M. Jakkapu, Shigeki Aoki, M. M. Khabibullin, E. A.G. Goodman, E. T. Atkin, R. Akutsu, T. Okusawa, K. Iwamoto, W. Shorrock, Jaroslaw Pasternak, G. Fiorillo, T. Kikawa, C. Vilela, J. Xia, S. Parsa, M. Ishitsuka, Yu. G. Kudenko, N. C. Hastings, H. K. Tanaka, D. A. Harris, K. Nishizaki, Marco Laveder, C. Yanagisawa, Y. Takeuchi, J. P. Coleman, P. B. Jurj, L. Wan, V. Paolone, Oleg Mineev, A. Dergacheva, Y. Nishimura, T. Yano, H. Nakamura, W. G. S. Vinning, C. Riccio, T. Dealtry, T. Nakadaira, S. Dolan, K. Wood, L. Pickering, E. Mazzucato, Y. Oyama, T. Kobayashi, M. Ziembicki, H. Kikutani, Y. Nakajima, C. Densham, A. Cudd, C. C. Delogu, J. C. Nugent, S. King, G. Zarnecki, A. D. Marino, G. De Rosa, J. G. Walsh, J. Lagoda, Yoshihiro Suzuki, M. Buizza Avanzini, R. A. Owen, N. Thamm, T. Maruyama, Samira Hassani, T. V. Ngoc, A. Cervera, K. Yamamoto, M. Hogan, L. Maret, G.D. Barr, K. Nakamura, Yufeng Wang, D. R. Hadley, A. C. Weber, J. A. Nowak, F. Bench, T. Ishida, T. Odagawa, A. Bravar, Ahmed Ali, A. Shaikhiev, P. N. Ratoff, T. Kutter, A. A. Sztuc, M. Batkiewicz-Kwasniak, T. Wachala, K. Zaremba, M. Tani, L. S.M. Lakshmi, L. Mellet, N. Akhlaq, M. Lawe, Jan T. Sobczyk, Lars Eklund, C. Bronner, T. Bonus, T. Kobata, Teppei Katori, M. B. Smy, L. N. Machado, R. Wendell, A. Rychter, M. Posiadala-Zezula, M. Kabirnezhad, C. Wret, K. Mavrokoridis, G. Collazuol, S. B. Boyd, T. Towstego, C. Francois, E. Rondio, P. Jonsson, B. Quilain, N. McCauley, A. Konaka, D. Munford, L. Labarga, J. McElwee, K. Skwarczynski, A. Minamino, Mark Scott, Stephanie Bron, L. O'Sullivan, T. Yoshida, K. Porwit, C. Wilkinson, C. Ruggles, G. Santucci, Y. Awataguchi, Hiroyuki Sekiya, F. Nova, S. L. Liu, A. Blondel, M. Malek, J. Holeczek, Kendall Mahn, A. Izmaylov, T. Radermacher, M. Cicerchia, Lester D.R. Thompson, M. Mezzetto, K. Kowalik, M. Yu, Masashi Yokoyama, M. Vagins, N. T. Hong Van, A. N. Khotjantsev, J. Zalipska, S. Mine, J. Walker, M. Guigue, M. Miura, K. M. Tsui, S. L. Cartwright, Tsuyoshi Nakaya, M. G. Catanesi, D. Coplowe, Roberto Spina, L. Marti-Magro, H. Sobel, T. S. Nonnenmacher, J. J. Jiang, A. Blanchet, M. Lamoureux, S. Zsoldos, V. Palladino, S. Nakayama, Y. Seiya, A. Longhin, M. Friend, A. Shaykina, Michelangelo Pari, Y. H. Xu, M. Pavin, S. J. Jenkins, T. Tsukamoto, Y. Ashida, Y. Fukuda, G. Christodoulou, K. Sakashita, M. Kuze, Masayuki Nakahata, C. Pidcott, Y. Uchida, Y. Yoshimoto, D. Sgalaberna, M. Reh, L. L. Kormos, B. Radics, B. Bourguille, A. Mefodiev, M. Ikeda, K. Nakayoshi, Kimihiro Okumura, S. Bolognesi, Sy Suzuki, M. Antonova, Y. Katayama, S. Emery-Schrenk, D. Douqa, W. Toki, H. M. O'Keeffe, Y. Sonoda, V. Q. Nguyen, M. O. Wascko, E. Kearns, and D. Pershey
Subjects: Physics, Proton, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, Monte Carlo method, T2K experiment, 01 natural sciences, 7. Clean energy, Nuclear physics, Transverse plane, 0103 physical sciences, Muon neutrino, Neutrino, 010306 general physics, Event (particle physics), Charged current
Abstract: This paper reports the first T2K measurement of the transverse kinematic imbalance in the single-$\pi^+$ production channel of neutrino interactions. We measure the differential cross sections in the muon-neutrino charged-current interaction on hydrocarbon with a single $\pi^+$ and at least one proton in the final state, at the ND280 off-axis near detector of the T2K experiment. The extracted cross sections are compared to the predictions from different neutrino-nucleus interaction event generators. Overall, the results show a preference for models which have a more realistic treatment of nuclear medium effects including the initial nuclear state and final-state interactions.
Published: 2021
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33. Creation and Validation of a Novel Sex‐Specific Mortality Risk Score in LVAD Recipients

Author: John Pennington, Yi-An Ko, Anurag Mehta, Subrat Das, Rebecca Steinberg, James K. Kirklin, Jennifer A Cowger, Aditi Nayak, Marc A. Simon, Yingtian Hu, Rongbing Xie, Chang Liu, Alanna A. Morris, and Robert L. Kormos
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, risk score, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Risk Factors, Internal medicine, left ventricular assist device, medicine, Humans, sex disparity, Registries, 030212 general & internal medicine, Sex Distribution, Original Research, Aged, Retrospective Studies, Heart Failure, Cardiovascular Surgery, Framingham Risk Score, Receiver operating characteristic, business.industry, Cardiogenic shock, Odds ratio, Middle Aged, medicine.disease, mortality, United States, Survival Rate, Residual risk, ROC Curve, Quartile, Ventricular assist device, Cardiology, Female, prognosis, Heart-Assist Devices, Mortality/Survival, Cardiology and Cardiovascular Medicine, business, Body mass index, Follow-Up Studies
Abstract: Background Prior studies have shown that women have worse 3‐month survival after receiving a left ventricular assist device compared with men. Currently used prognostic scores, including the Heartmate II Risk Score, do not account for the increased residual risk in women. We used the IMACS (International Society for Heart and Lung Transplantation Mechanically Assisted Circulatory Support) registry to create and validate a sex‐specific risk score for early mortality in left ventricular assist device recipients. Methods and Results Adult patients with a continuous‐flow LVAD from the IMACS registry were randomly divided into a derivation cohort (DC; n=9113; 21% female) and a validation cohort (VC; n=6074; 21% female). The IMACS Risk Score was developed in the DC to predict 3‐month mortality, from preoperative candidate predictors selected using the Akaike information criterion, or significant sex × variable interaction. In the DC, age, cardiogenic shock at implantation, body mass index, blood urea nitrogen, bilirubin, hemoglobin, albumin, platelet count, left ventricular end‐diastolic diameter, tricuspid regurgitation, dialysis, and major infection before implantation were retained as significant predictors of 3‐month mortality. There was significant ischemic heart failure × sex and platelet count × sex interaction. For each quartile increase in IMACS risk score, men (odds ratio [OR], 1.86; 95% CI, 1.74–2.00; P P P Conclusions A sex‐specific risk score provides excellent risk prediction in LVAD recipients.
Published: 2021
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34. Measurements of ν̅ μ and ν̅ μ + ν μ charged-current cross-sections without detected pions or protons on water and hydrocarbon at a mean anti-neutrino energy of 0.86 GeV

Author: M. Barbi, T. Vladisavljevic, A. Longhin, A. Shaykina, M. Lawe, Michelangelo Pari, A. Blanchet, Thorsten Lux, Y. Sonoda, L. Molina Bueno, T. Kikawa, S. Parsa, V. Q. Nguyen, H. W. Sobel, M. Gonin, J. Xia, A. T. Suzuki, A. Dergacheva, C. E. R. Naseby, J. F. Martin, N. Kukita, M. Licciardi, T. Feusels, Y. Tanihara, C. Alt, T. Nakadaira, Shuji Tanaka, R. Shah, J. Lagoda, R. J. Wilson, M. Pavin, S. J. Jenkins, J. R. Wilson, D. Fukuda, L. O'Sullivan, Jochen Steinmann, Xianguo Lu, M. R. Vagins, H. Kikutani, J. G. Walsh, A. Bubak, P. Jonsson, R. A. Owen, P. Novella, K. Iwamoto, K. Niewczas, André Rubbia, Jaroslaw Pasternak, Y. Yoshimoto, M. Batkiewicz-Kwasniak, M. Miura, Marco Laveder, A. Zykova, J. P. Coleman, T. Hayashino, Yuto Ashida, A. J. Finch, R. Fukuda, C. Wret, A. Knox, T. Arihara, T. Sekiguchi, R. Akutsu, J. Morrison, N. McCauley, M. Guigue, A. Pritchard, P. B. Jurj, A. A. Sztuc, J. L. Palomino, G. Zarnecki, Patrick Dunne, P. Paudyal, A. Blondel, T. Koga, B. A. Popov, T. Honjo, A. Rychter, P. Hamacher-Baumann, Oleg Mineev, C. Pistillo, M. Jakkapu, M. Buizza Avanzini, B. Jamieson, G. Christodoulou, K. Nakamura, T. A. Doyle, E. Reinherz-Aronis, Keigo Nakamura, Takaaki Kajita, E. Rondio, B. Quilain, C. J. Densham, K. Yasutome, K. Fusshoeller, Hiroyuki Sekiya, S. L. Cartwright, F. Shaker, W. Uno, C. M. Nantais, F. Nova, K. Porwit, P. F. Denner, R. Fujita, Y. Fukuda, Kendall Mahn, A. K. Ichikawa, V. Paolone, Akitaka Ariga, Ko Okumura, G. Pintaudi, S. Moriyama, Kate Scholberg, D. Cherdack, M. Ziembicki, S. Roth, J. Kameda, J. Zalipska, C. Vilela, S. Kuribayashi, E. S. Pinzon Guerra, Th. A. Mueller, B. Radics, M. Ikeda, A. Zalewska, Federico Sanchez, B. Bourguille, Yousuke Kataoka, Z. Vallari, Y. Takeuchi, K. Wood, R.P. Kurjata, L. F. Thompson, S. Valder, T. Ogawa, T. Golan, M. Hartz, E. D. Zimmerman, C. McGrew, Masayuki Nakahata, C. Pidcott, L. Koch, Y. Asada, A. Gorin, G. A. Fiorentini, A. Knight, A. Shvartsman, N. Teshima, C. Checchia, A. Bravar, Vladimir Volkov, Y. Uchida, Shigeki Aoki, Yuichi Oyama, A. Nakamura, S. Suvorov, R. P. Litchfield, Takatomi Yano, Y. Hayato, C. Andreopoulos, R. A. Wendell, S. Bolognesi, H. M. O'Keeffe, J. Holeczek, S. Hassani, G. Fiorillo, T. Radermacher, Thomas B. Campbell, Yuki Fujii, K. Nakayoshi, D. Bravo Berguño, E. Radicioni, T. Kobata, W. H. Toki, Hiromasa Tanaka, V. A. Matveev, M. B. Smy, T. Towstego, L. Maret, P. N. Ratoff, T. Kutter, Koji Yamamoto, M. McCarthy, M. Zito, Hidekazu Kakuno, Pablo Fernandez, M. O. Wascko, S. Mine, G. Yang, E. Mazzucato, K. Kowalik, Laura Gutermuth Anthony, M. Yu, D. L. Wark, F. Di Lodovico, Yutaka Nakajima, Jan Kisiel, T. Bonus, M. Friend, Teppei Katori, Yanbin Wang, M. Tada, D. J. Payne, K. Abe, T. Okusawa, Jungsang Kim, S. Y. Suzuki, N. Izumi, D. Vargas, J. Dumarchez, N. Chikuma, Vincenzo Berardi, D. Barrow, Etam Noah, C. Bronner, Steven C. Johnson, S. Nakayama, F. J. P. Soler, L. L. Kormos, W. Shorrock, Masaki Ishitsuka, Yoshihiro Suzuki, M. Kuze, T. Tsukamoto, K. Skwarczynski, L. Labarga, A. Eguchi, K. Sakashita, S. M. Oser, L. Berns, S. Yen, M. Hogan, T. Kobayashi, N. C. Hastings, M. Antonova, R. Okada, T. Odagawa, Yoshikazu Yamada, A. N. Khotjantsev, Alan Cosimo Ruggeri, J. Schwehr, D. Karlen, T. Yoshida, Y. Seiya, A. Minamino, Hidetoshi Kubo, A. D. Marino, Hyun-Chul Kim, A. Izmaylov, L. Pickering, Y. Nishimura, S. Manly, S. Ban, S. Bienstock, K. M. Tsui, K. S. McFarland, F. Bench, A. C. Weber, Y. Katayama, G. Vasseur, C. Jesús-Valls, C. Ruggles, G. Santucci, O. Drapier, D. A. Harris, S. Emery-Schrenk, H. K. Tanaka, T. Wachala, T. Ishida, S. P. Kasetti, N. Akhlaq, M. M. Khabibullin, S. L. Liu, M. Posiadala-Zezula, M. G. Catanesi, M. Malek, L. Magaletti, C. Giganti, N. Dokania, S. Berkman, Roberto Spina, A. C. Kaboth, A. Cervera, G. Collazuol, Mark Scott, M. Kabirnezhad, K. Mavrokoridis, J. A. Nowak, A. Chappell, Lars Eklund, T. S. Nonnenmacher, C. Barry, S. Murphy, C. Riccio, C. Mauger, T. Dealtry, E. T. Atkin, M. Cicerchia, Alexei Yu. Smirnov, Yuta Kato, K. Nishikawa, M. Lamoureux, L. N. Machado, J. T. Haigh, S. Zsoldos, V. Palladino, S. B. Boyd, L. Marti-Magro, K. Zaremba, Jan T. Sobczyk, Stephanie Bron, Atsushi Takeda, J. McElwee, D. Sgalaberna, Ahmed Ali, C. Francois, Y. Awataguchi, Xiao-yan Li, W. G. S. Vinning, C. Wilkinson, T. V. Ngoc, C. Yanagisawa, Gareth J. Barker, Yuuki Nakano, D. Coplowe, T. Ishii, A. Hiramoto, T. Hasegawa, Takahiko Matsubara, S. V. Cao, C. Touramanis, M. J. Wilking, M. Jiang, Antonio Ereditato, N. Yershov, T. Maruyama, K. Gameil, J. C. Nugent, G.D. Barr, S. King, F. Iacob, M. Mezzetto, D. R. Hadley, Y. Nagai, W. C. Parker, M. Tani, E. Kearns, G. C. Penn, Masashi Yokoyama, M. Tzanov, C. J. Metelko, Yu.A. Kudenko, A. Dabrowska, K. Matsushita, D. Brailsford, N. T. Hong Van, J. Walker, A. Mefodiev, S. Dolan, T. Lindner, A. Cudd, S. R. Dennis, Tsuyoshi Nakaya, C. M. Schloesser, C. K. Jung, Masato Shiozawa, L. Ludovici, A. Kostin, S. Bhadra, L. Cook, A. Beloshapkin, G. De Rosa, J. Calcutt, A. Shaikhiev, A. Konaka, L. Munteanu, M. Tajima, and Yusuke Koshio
Subjects: chemistry.chemical_classification, Physics, Particle physics, Muon, Proton, 010308 nuclear & particles physics, General Physics and Astronomy, 01 natural sciences, Hydrocarbon, Pion, chemistry, 0103 physical sciences, 010306 general physics, Nucleon, Energy (signal processing), Charged current, Bar (unit)
Abstract: We report measurements of the flux-integrated ν̅μ and ν̅μ + νμ charged-current cross-sections on water and hydrocarbon targets using the T2K anti-neutrino beam with a mean beam energy of 0.86 GeV. The signal is defined as the (anti-)neutrino charged-current interaction with one induced $\mu^\pm$ and no detected charged pion or proton. These measurements are performed using a new WAGASCI module recently added to the T2K setup in combination with the INGRID Proton Module. The phase space of muons is restricted to the high-detection efficiency region, $p_{\mu}>400~{\rm MeV}/c$ and $\theta_{\mu}200~{\rm MeV}/c$, $\theta_{\pi}600~{\rm MeV}/c$, $\theta_{\rm p}
Published: 2021
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35. Clinical outcomes and healthcare expenditures in the real world with left ventricular assist devices - The CLEAR-LVAD study

Author: Scott C. Silvestry, JoAnn Lindenfeld, Francis D. Pagani, Gregory J. Roberts, Douglas A. Horstmanshof, Nirav Dalal, Mandeep R. Mehra, Joseph G. Rogers, Robert L. Kormos, Joseph C. Cleveland, Rupinder Bharmi, Pavan Atluri, and Jennifer A Cowger
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Waiting Lists, Heart Ventricles, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Health care, Medicine, Humans, 030212 general & internal medicine, Propensity Score, Aged, Retrospective Studies, Heart Failure, Transplantation, business.industry, Proportional hazards model, Hazard ratio, Middle Aged, United States, Clinical trial, Survival Rate, Treatment Outcome, Emergency medicine, Cohort, Propensity score matching, Heart Transplantation, Surgery, Observational study, Female, Heart-Assist Devices, Health Expenditures, Cardiology and Cardiovascular Medicine, business, Cohort study, Follow-Up Studies
Abstract: BACKGROUND Several distinctly engineered left ventricular assist devices (LVADs) are in clinical use. However, contemporaneous real world comparisons have not been conducted, and clinical trials were not powered to evaluate differential survival outcomes across devices. OBJECTIVES Determine real world survival outcomes and healthcare expenditures for commercially available durable LVADs. METHODS Using a retrospective observational cohort design, Medicare claims files were linked to manufacturer device registration data to identify de-novo, durable LVAD implants performed between January 2014 and December 2018, with follow-up through December 2019. Survival outcomes were compared using a Cox proportional hazards model stratified by LVAD type and validated using propensity score matching. Healthcare resource utilization was analyzed across device types by using nonparametric bootstrap analysis methodology. Primary outcome was survival at 1-year and total Part A Medicare payments. RESULTS A total of 4,195 de-novo LVAD implants were identified in fee-for-service Medicare beneficiaries (821 HeartMate 3; 1,840 HeartMate II; and 1,534 Other-VADs). The adjusted hazard ratio for mortality at 1-year (confirmed in a propensity score matched analysis) for the HeartMate 3 vs HeartMate II was 0.64 (95% CI; 0.52-0.79, p< 0.001) and for the HeartMate 3 vs Other-VADs was 0.51 (95% CI; 0.42-0.63, p < 0.001). The HeartMate 3 cohort experienced fewer hospitalizations per patient-year vs Other-VADs (respectively, 2.8 vs 3.2 EPPY hospitalizations, p < 0.01) and 6.1 fewer hospital days on average (respectively, 25.2 vs 31.3 days, p < 0.01). The difference in Medicare expenditures, conditional on survival, for HeartMate 3 vs HeartMate II was -$10,722, p < 0.001 (17.4% reduction) and for HeartMate 3 vs Other-VADs was -$17,947, p < 0.001 (26.1% reduction). CONCLUSIONS In this analysis of a large, real world, United States. administrative dataset of durable LVADs, we observed that the HeartMate 3 had superior survival, reduced healthcare resource use, and lower healthcare expenditure compared to other contemporary commercially available LVADs.
Published: 2020

36. Abstract 14251: Creation and Validation of a Novel Sex-specific Mortality Risk Score in LVAD Patients

Author: Anurag Mehta, Aditi Nayak, Chang Liu, Marc A. Simon, John Pennington, Alanna A. Morris, Rebecca Steinberg, James K. Kirklin, Jennifer A Cowger, Yi-An Ko, Yingtian Hu, Subrat Das, Robert L. Kormos, and Rongbing Xie
Subjects: medicine.medical_specialty, Framingham Risk Score, Heartmate ii, business.industry, Physiology (medical), Internal medicine, Medicine, Specific mortality, Cardiology and Cardiovascular Medicine, business
Abstract: Introduction: Prior studies have shown that females have worse 3-month survival post-LVAD. Currently used prognostic scores including the Heartmate II Risk Score (HMRS), were developed in >75% male cohorts, and may not account for the increased residual risk in females. Hypothesis: A sex-specific risk score will predict post-LVAD mortality in females, and perform better than HMRS. Methods: Adult CF-LVAD patients from the ISHLT Mechanically Assisted Circulatory Support (IMACS) registry (Implant years: Jan 2013 - Sep 2017, age: 56 ± 13 yrs, 21% female, 36% centrifugal pumps) were randomly divided into derivation (DC, n=9113, 21% female) and validation cohorts (VC, n=6074, 21% female). Primary outcome of interest was 3-month mortality. IMACS risk score (IMACS-RS) was developed in the DC, from pre-operative candidate predictors selected using Akaike Information Criterion, or significant sex*variable interaction. Results: There were 1,466 deaths (9.7%) within 3 months after implant. In the DC, age, cardiogenic shock at implant, Body Mass Index, Blood Urea Nitrogen, bilirubin, hemoglobin, albumin, platelet count, LV End Diastolic Diameter, Tricuspid Regurgitation, dialysis and major infection pre-implant were retained as significant predictors of 3-month mortality. There was a significant ischemic HF*sex and platelet count*sex interaction. For each quartile increase in IMACS-RS, females had 93% increased odds (p Conclusions: A sex-specific risk score provides excellent risk prediction in LVAD patients. Future prognostic studies in advanced HF should present sex-specific secondary outcomes.
Published: 2020
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37. Moving teaching online during the COVID-19 pandemic

Author: Stan Zochowski, L. L. Kormos, Alison Voice, J. A. Nowak, Helen Vaughan, and David Sands
Subjects: 2019-20 coronavirus outbreak, Geography, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pandemic, General Physics and Astronomy, Virology
Published: 2020
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38. Search for hep solar neutrinos and the diffuse supernova neutrino background using all three phases of the Sudbury Neutrino Observatory

Author: C. E. Okada, Ilan Levine, David A. Sinclair, D. Chauhan, J. Wendland, J. F. Wilkerson, B. Beltran, F. B. Descamps, Jocelyn Monroe, M. H. Schwendener, N. Gagnon, M. Jerkins, T. Sonley, F. Zhang, N. S. Oblath, G. D. Orebi Gann, H. Deng, B. Aharmim, J. R. Leslie, L. C. Stonehill, R. W. Ollerhead, J. Law, A. L. Hallin, B. T. Cleveland, B. C. Robertson, E. Blucher, Bei Cai, Ryuta Hazama, G. Doucas, K. Boudjemline, N. Tolich, M. Huang, H. Wan Chan Tseung, S. Habib, S. Majerus, Yuen-Dat Chan, K. Graham, T. Kutter, T. J. Winchester, Alain Bellerive, D. L. Wark, M. L. Miller, J. Heise, S. M. Oser, M. Bergevin, L. L. Kormos, R. D. Martin, Andrew Hime, N. McCauley, P. Jagam, S. R. Elliott, G. T. Ewan, C. Kraus, A. Krüger, Keith Rielage, R. G. H. Robertson, S. D. Reitzner, S. N. Ahmed, M. Kos, J. C. Loach, O. Simard, R. Van Berg, P. L. Drouin, K. Gilje, R. L. Hahn, I. Lawson, R. J. Ford, Monica Dunford, C. J. Virtue, E. W. Beier, A. J. Noble, J. Maneira, A. W. P. Poon, J. Caravaca, F. Fleurot, B. L. Wall, A. E. Anthony, Christopher C. M. Kyba, P. J. Doe, G. Prior, N. West, W. J. Heintzelman, Hal Evans, S. J. M. Peeters, C. Howard, J. Farine, H. M. O'Keeffe, K. T. Lesko, S. D. Biller, R. A. Ott, Bernie G. Nickel, P. J. Harvey, Jochen Klein, K. J. Keeter, E. Guillian, H. B. Mak, Minfang Yeh, G. Tešić, N. A. Jelley, S. McGee, J. Tm. Goon, N. Barros, A. B. McDonald, E. D. Hallman, R. MacLellan, T. Tsui, S. R. Seibert, Min Chen, C. B. Krauss, B. A. VanDevender, P. Skensved, D. Waller, B. Jamieson, R. Bonventre, James R. Wilson, B. J. Land, X. Dai, J. A. Secrest, J. A. Detwiler, G. A. Cox, R. Lange, Benjamin Monreal, A. Mastbaum, H. Fergani, R. L. Helmer, Kai Zuber, A. Wright, M. G. Boulay, A. LaTorre, E. J. Callaghan, K. Labe, and Joseph A. Formaggio
Subjects: Physics, Standard solar model, Sudbury Neutrino Observatory, 010308 nuclear & particles physics, Solar neutrino, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Supernova, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Neutrino, 010306 general physics, Nuclear Experiment
Abstract: A search has been performed for neutrinos from two sources, the $hep$ reaction in the solar $pp$ fusion chain and the $��_e$ component of the diffuse supernova neutrino background (DSNB), using the full dataset of the Sudbury Neutrino Observatory with a total exposure of 2.47 kton-years after fiducialization. The $hep$ search is performed using both a single-bin counting analysis and a likelihood fit. We find a best-fit flux that is compatible with solar model predictions while remaining consistent with zero flux, and set a one-sided upper limit of $��_{hep} < 30\times10^{3}~\mathrm{cm}^{-2}~\mathrm{s}^{-1}$ [90% credible interval (CI)]. No events are observed in the DSNB search region, and we set an improved upper bound on the $��_e$ component of the DSNB flux of $��^\mathrm{DSNB}_{��_e} < 19~\textrm{cm}^{-2}~\textrm{s}^{-1}$ (90% CI) in the energy range $22.9 < E_��< 36.9$~MeV., 11 pages, 6 figures
Published: 2020

39. A comparison of air-cell and gel surgical table pads and an evaluation of the influence of pressure distribution and other factors on pressure injury prevention

Author: Ana Luiza Caltabiano Allegretti, Robert L. Kormos, Sandra Guzman, and David M. Brienza
Subjects: Adult, Male, Peak pressure, medicine.medical_treatment, Operative Time, Dentistry, Operating Tables, Dermatology, Beds, Pathology and Forensic Medicine, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Interface pressure, medicine, Pressure, Humans, Aged, Monitoring, Physiologic, Pressure Ulcer, Tissue deformation, 030504 nursing, Pressure injury, business.industry, Middle Aged, Operating table, Ventricular assist device, Air cell, Female, 0305 other medical science, business
Abstract: Guidelines for pressure injury prevention consider the use of pressure-redistributing pads to prevent tissue deformation. However, limited research exists to assess the pressure distribution provided by the operating tables and the effectiveness of pressure-redistributing pads in preventing pressure injuries. In this study, we compared the pressure distribution properties of two surgical table pads and identified parameters influencing pressure injury outcomes after a lengthy surgical procedure. Twenty-seven patients undergoing left ventricular assist device implantation surgery participated in the study. Participants were randomly assigned to use either an air cell-based pad or a gel pad. Interface pressure was recorded during the surgery. We analyzed the effect of surgical table pad type, interface pressure distribution and pressure injury outcomes and analyzed what characteristics of the patients and the interface pressure are most influential for the development of pressure injuries. Comparing the interface pressure parameters between the air-cell group and the gel group, only the peak pressure index x time was significantly different (p 0.05). We used univariate logistic regression analysis to identify significant predictors for the pressure injury outcome. The support surface was not significant. And, among patient characteristics, only age and BMI were significant (p ≤ 0.05). Among the interface pressure parameters, pressure density maxima, peak pressure index x time, and coefficient of variation were significant for pressure injury outcome (p ≤ 0.05). Peak pressure index, average pressure, and the surgery length were not statistically significant for pressure injury outcomes.
Published: 2020

40. The Hyper-Kamiokande Experiment -- Snowmass LOI

Author: Hyper-Kamiokande Collaboration, K. Abe, P. Adrich, H. Aihara, R. Akutsu, I. Alekseev, A. Ali, F. Ameli, L. H. V. Anthony, A. Araya, Y. Asaoka, V. Aushev, I. Bandac, M. Barbi, G. Barr, M. Batkiewicz-Kwasniak, M. Bellato, V. Berardi, L. Bernard, E. Bernardini, L. Berns, S. Bhadra, J. Bian, A. Blanchet, A. Blondel, A. Boiano, S. Bolognesi, L. Bonavera, S. Borjabad, T. Boschi, D. Bose, S . B. Boyd, C. Bozza, A. Bravar, C. Bronner, A. Bubak, A. Buchowicz, M. Buizza Avanzini, F. S. Cafagna, N. F. Calabria, J. M. Calvo-Mozota, S. Cao, M. G. Catanesi, S. Chakraborty, J. H. Choi, S. Choubey, M. Cicerchia, J. Coleman, G. Collazuol, S. Cuen-Rochin, M. Danilov, E. De la Fuente, P. de Perio, G. De Rosa, T. Dealtry, C. J. Densham, A. Dergacheva, N. Deshmukh, M. M. Devi, F. Di Lodovico, P. Di Meo, I. Di Palma, T. A. Doyle, E. Drakopoulou, O. Drapier, J. Dumarchez, L. Eklund, S. El Hedri, J. Ellis, S. Emery, A. Esmaili, S. Fedotov, J. Feng, E. Fernández-Martinez, P. Ferrario, B. Ferrazzi, A. Finch, C. Finley, G. Fiorillo, M. Fitton, M. Friend, Y. Fujii, Y. Fukuda, G. Galinski, J. Gao, C. Garde, A. Garfagnini, S. Garode, L. Gialanella, C. Giganti, J. J. Gomez-Cadenas, M. Gonin, J. González-Nuevo, A. Gorin, R. Gornea, F. Gramegna, M. Grassi, G. Grella, M. Guigue, D. R. Hadley, M. Harada, M. Hartz, S. Hassani, N. C. Hastings, Y. Hayato, K. Hiraide, K. Hoshina, K. Hultqvist, F. Iacob, A. K. Ichikawa, W. Idrissi Ibnsalih, M. Ikeda, M. Inomoto, A. Ioannisian, T. Ishida, K. Ishidoshiro, H. Ishino, M. Ishitsuka, H. Ito, S. Ito, Y. Itow, K. Iwamoto, N. Izumi, S. Izumiyama, M. Jakkapu, B. Jamieson, J. S. Jang, H. S. Jo, P. Jonsson, K. K. Joo, T. Kajita, H. Kakuno, J. Kameda, Y. Kano, D. Karlen, Y. Kataoka, A. Kato, T. Katori, N. Kazarian, M. Khabibullin, A. Khotjantsev, T. Kikawa, J. Y. Kim, S. B. Kim, S. King, T. Kinoshita, J. Kisiel, A. Klekotko, T. Kobayashi, L. Koerich, N. Kolev, A. Konaka, L. L. Kormos, Y. Koshio, Y. Kotsar, K. A. Kouzakov, K. L. Kowalik, L. Kravchuk, A. P. Kryukov, Y. Kudenko, T. Kumita, R. Kurjata, T. Kutter, M. Kuze, K. Kwak, M. La Commara, L. Labarga, J. Lagoda, M. Lamoureux, M. Laveder, L. Lavitola, J. Lee, R. Leitner, V. Lezaun, I. T. Lim, T. Lindner, R. P. Litchfield, K. R. Long, A. Longhin, P. Loverre, X. Lu, L. Ludovici, Y. Maekawa, L. Magaletti, K. Magar, Y. Makida, M. Malek, M. Malinský, T. Marchi, C. Mariani, A. Marinelli, K. Martens, Ll. Marti, J. F. Martin, D. Martin, J. Marzec, T. Matsubara, R. Matsumoto, N. McCauley, A. Medhi, P. Mehta, L. Mellet, H. Menjo, M. Mezzetto, J. Migenda, P. Migliozzi, S. Miki, A. Minamino, S. Mine, O. Mineev, A. Mitra, M. Miura, R. Moharana, C. M. Mollo, T. Mondal, M. Mongelli, F. Monrabal, D. H. Moon, C. S. Moon, S. Moriyama, T. Mueller, Y. Nagao, T. Nakadaira, K. Nakagiri, M. Nakahata, S. Nakai, Y. Nakajima, K. Nakamura, KI. Nakamura, H. Nakamura, Y. Nakano, T. Nakaya, S. Nakayama, K. Nakayoshi, L. Nascimento Machado, C. E. R. Naseby, B. Navarro-Garcia, M. Needham, K. Niewczas, Y. Nishimura, F. Nova, J. C. Nugent, H. Nunokawa, W. Obrebski, J. P. Ochoa-Ricoux, E. O'Connor, N. Ogawa, T. Ogitsu, K. Okamoto, H. M. O'Keeffe, K. Okumura, Y. Onishchuk, F. Orozco-Luna, A. Oshlianskyi, N. Ospina, M. Ostrowski, E. O'Sullivan, Y. Oyama, H. Ozaki, M. Y. Pac, P. Paganini, V. Palladino, M. Pari, J. Pasternak, C. Pastore, G. Pastuszak, D. A. Patel, M. Pavin, D. Payne, C. Peña-Garay, C. Pidcott, S. Playfer, B. W. Pointon, A. Popov, B. Popov, K. Porwit, M. Posiadala-Zezula, G. Pronost, N. W. Prouse, B. Quilain, A. A. Quiroga, E. Radicioni, B. Radics, P. J. Rajda, M. Rescigno, G. Ricciardi, B. Richards, E. Rondio, B. Roskovec, S. Roth, C. Rott, A. Rubbia, A. C. Ruggeri, S. Russo, A. Rychter, D. Ryu, K. Sakashita, S. Samani, F. Sánchez, M. L. Sánchez, S. Sano, J. D. Santos, G. Santucci, P. Sarmah, K. Sato, M. Scott, Y. Seiya, T. Sekiguchi, H. Sekiya, J. W. Seo, D. Sgalaberna, A. Shaykina, I. Shimizu, C. D. Shin, M. Shinoki, M. Shiozawa, N. Skrobova, K. Skwarczynski, M. B. Smy, J. Sobczyk, H. W. Sobel, F. J. P. Soler, Y. Sonoda, R. Spina, B. Spisso, P. Spradlin, K. L. Stankevich, L. Stawarz, S. M. Stellacci, A. I. Studenikin, S. L. Suárez Gómez, T. Suganuma, S. Suvorov, Y. Suwa, A. T. Suzuki, S. Suzuki, Y. Suzuki, D. Svirida, M. Taani, M. Tada, A. Takeda, Y. Takemoto, A. Takenaka, A. Taketa, Y. Takeuchi, H. Tanaka, H. I. Tanaka, M. Tanaka, T. Tashiro, M. Thiesse, L. F. Thompson, A. K. Tomatani-Sánchez, G. Tortone, K. M. Tsui, T. Tsukamoto, M. Tzanov, Y. Uchida, M. R. Vagins, S. Valder, V. Valentino, G. Vasseur, A. Vijayvargi, W. G. S. Vinning, D. Vivolo, R. B. Vogelaar, M. M. Vyalkov, T. Wachala, J. Walker, D. Wark, M. O. Wascko, R. A. Wendell, J. R. Wilson, S. Wronka, J. Xia, Y. Yamaguchi, K. Yamamoto, T. Yano, N. Yershov, M. Yokoyama, J. Yoo, I. Yu, T. Zakrzewski, B. Zaldivar, J. Zalipska, K. Zaremba, G. Zarnecki, M. Ziembicki, K. Zietara, M. Zito, S. Zsoldos, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Hyper-Kamiokande, HEP, INSPIRE, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Collaboration, Hyper-Kamiokande, Abe, K., Adrich, P., Aihara, H., Akutsu, R., Alekseev, I., Ali, A., Ameli, F., Anthony, L. H. V., Araya, A., Asaoka, Y., Aushev, V., Bandac, I., Barbi, M., Barr, G., Batkiewicz-Kwasniak, M., Bellato, M., Berardi, V., Bernard, L., Bernardini, E., Berns, L., Bhadra, S., Bian, J., Blanchet, A., Blondel, A., Boiano, A., Bolognesi, S., Bonavera, L., Borjabad, S., Boschi, T., Bose, D., Boyd, S . B., Bozza, C., Bravar, A., Bronner, C., Bubak, A., Buchowicz, A., Buizza Avanzini, M., Cafagna, F. S., Calabria, N. F., Calvo-Mozota, J. M., Cao, S., Catanesi, M. G., Chakraborty, S., Choi, J. H., Choubey, S., Cicerchia, M., Coleman, J., Collazuol, G., Cuen-Rochin, S., Danilov, M., De la Fuente, E., de Perio, P., De Rosa, G., Dealtry, T., Densham, C. J., Dergacheva, A., Deshmukh, N., Devi, M. M., Di Lodovico, F., Di Meo, P., Di Palma, I., Doyle, T. A., Drakopoulou, E., Drapier, O., Dumarchez, J., Eklund, L., El Hedri, S., Ellis, J., Emery, S., Esmaili, A., Fedotov, S., Feng, J., Fernández-Martinez, E., Ferrario, P., Ferrazzi, B., Finch, A., Finley, C., Fiorillo, G., Fitton, M., Friend, M., Fujii, Y., Fukuda, Y., Galinski, G., Gao, J., Garde, C., Garfagnini, A., Garode, S., Gialanella, L., Giganti, C., Gomez-Cadenas, J. J., Gonin, M., González-Nuevo, J., Gorin, A., Gornea, R., Gramegna, F., Grassi, M., Grella, G., Guigue, M., Hadley, D. R., Harada, M., Hartz, M., Hassani, S., Hastings, N. C., Hayato, Y., Hiraide, K., Hoshina, K., Hultqvist, K., Iacob, F., Ichikawa, A. K., Idrissi Ibnsalih, W., Ikeda, M., Inomoto, M., Ioannisian, A., Ishida, T., Ishidoshiro, K., Ishino, H., Ishitsuka, M., Ito, H., Ito, S., Itow, Y., Iwamoto, K., Izumi, N., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, J. S., Jo, H. S., Jonsson, P., Joo, K. K., Kajita, T., Kakuno, H., Kameda, J., Kano, Y., Karlen, D., Kataoka, Y., Kato, A., Katori, T., Kazarian, N., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kim, J. Y., Kim, S. B., King, S., Kinoshita, T., Kisiel, J., Klekotko, A., Kobayashi, T., Koerich, L., Kolev, N., Konaka, A., Kormos, L. L., Koshio, Y., Kotsar, Y., Kouzakov, K. A., Kowalik, K. L., Kravchuk, L., Kryukov, A. P., Kudenko, Y., Kumita, T., Kurjata, R., Kutter, T., Kuze, M., Kwak, K., La Commara, M., Labarga, L., Lagoda, J., Lamoureux, M., Laveder, M., Lavitola, L., Lee, J., Leitner, R., Lezaun, V., Lim, I. T., Lindner, T., Litchfield, R. P., Long, K. R., Longhin, A., Loverre, P., Lu, X., Ludovici, L., Maekawa, Y., Magaletti, L., Magar, K., Makida, Y., Malek, M., Malinský, M., Marchi, T., Mariani, C., Marinelli, A., Martens, K., Marti, Ll., Martin, J. F., Martin, D., Marzec, J., Matsubara, T., Matsumoto, R., Mccauley, N., Medhi, A., Mehta, P., Mellet, L., Menjo, H., Mezzetto, M., Migenda, J., Migliozzi, P., Miki, S., Minamino, A., Mine, S., Mineev, O., Mitra, A., Miura, M., Moharana, R., Mollo, C. M., Mondal, T., Mongelli, M., Monrabal, F., Moon, D. H., Moon, C. S., Moriyama, S., Mueller, T., Nagao, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakai, S., Nakajima, Y., Nakamura, K., Nakamura, Ki., Nakamura, H., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Nascimento Machado, L., Naseby, C. E. R., Navarro-Garcia, B., Needham, M., Niewczas, K., Nishimura, Y., Nova, F., Nugent, J. C., Nunokawa, H., Obrebski, W., Ochoa-Ricoux, J. P., O'Connor, E., Ogawa, N., Ogitsu, T., Okamoto, K., O'Keeffe, H. M., Okumura, K., Onishchuk, Y., Orozco-Luna, F., Oshlianskyi, A., Ospina, N., Ostrowski, M., O'Sullivan, E., Oyama, Y., Ozaki, H., Pac, M. Y., Paganini, P., Palladino, V., Pari, M., Pasternak, J., Pastore, C., Pastuszak, G., Patel, D. A., Pavin, M., Payne, D., Peña-Garay, C., Pidcott, C., Playfer, S., Pointon, B. W., Popov, A., Popov, B., Porwit, K., Posiadala-Zezula, M., Pronost, G., Prouse, N. W., Quilain, B., Quiroga, A. A., Radicioni, E., Radics, B., Rajda, P. J., Rescigno, M., Ricciardi, G., Richards, B., Rondio, E., Roskovec, B., Roth, S., Rott, C., Rubbia, A., Ruggeri, A. C., Russo, S., Rychter, A., Ryu, D., Sakashita, K., Samani, S., Sánchez, F., Sánchez, M. L., Sano, S., Santos, J. D., Santucci, G., Sarmah, P., Sato, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Sgalaberna, D., Shaykina, A., Shimizu, I., Shin, C. D., Shinoki, M., Shiozawa, M., Skrobova, N., Skwarczynski, K., Smy, M. B., Sobczyk, J., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Spina, R., Spisso, B., Spradlin, P., Stankevich, K. L., Stawarz, L., Stellacci, S. M., Studenikin, A. I., Suárez Gómez, S. L., Suganuma, T., Suvorov, S., Suwa, Y., Suzuki, A. T., Suzuki, S., Suzuki, Y., Svirida, D., Taani, M., Tada, M., Takeda, A., Takemoto, Y., Takenaka, A., Taketa, A., Takeuchi, Y., Tanaka, H., Tanaka, H. I., Tanaka, M., Tashiro, T., Thiesse, M., Thompson, L. F., Tomatani-Sánchez, A. K., Tortone, G., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Valder, S., Valentino, V., Vasseur, G., Vijayvargi, A., Vinning, W. G. S., Vivolo, D., Vogelaar, R. B., Vyalkov, M. M., Wachala, T., Walker, J., Wark, D., Wascko, M. O., Wendell, R. A., Wilson, J. R., Wronka, S., Xia, J., Yamaguchi, Y., Yamamoto, K., Yano, T., Yershov, N., Yokoyama, M., Yoo, J., Yu, I., Zakrzewski, T., Zaldivar, B., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zietara, K., Zito, M., and Zsoldos, S.
Subjects: nucleon: decay, Physics - Instrumentation and Detectors, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], Cherenkov counter: water, Physics::Instrumentation and Detectors, J-PARC Lab, High Energy Physics::Phenomenology, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), KAMIOKANDE, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], upgrade, High Energy Physics::Experiment, Physics - Instrumentation and Detector, neutrino: oscillation, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], activity report
Abstract: Hyper-Kamiokande is the next generation underground water Cherenkov detector that builds on the highly successful Super-Kamiokande experiment. The detector which has an 8.4~times larger effective volume than its predecessor will be located along the T2K neutrino beamline and utilize an upgraded J-PARC beam with 2.6~times beam power. Hyper-K's low energy threshold combined with the very large fiducial volume make the detector unique, that is expected to acquire an unprecedented exposure of 3.8~Mton$\cdot$year over a period of 20~years of operation. Hyper-Kamiokande combines an extremely diverse science program including nucleon decays, long-baseline neutrino oscillations, atmospheric neutrinos, and neutrinos from astrophysical origins. The scientific scope of this program is highly complementary to liquid-argon detectors for example in sensitivity to nucleon decay channels or supernova detection modes. Hyper-Kamiokande construction has started in early 2020 and the experiment is expected to start operations in 2027. The Hyper-Kamiokande collaboration is presently being formed amongst groups from 19 countries including the United States, whose community has a long history of making significant contributions to the neutrino physics program in Japan. US physicists have played leading roles in the Kamiokande, Super-Kamiokande, EGADS, K2K, and T2K programs., 6 pages, prepared as Snowmass2021 LOI
Published: 2020

41. First measurement of the charged current ν¯μ double differential cross section on a water target without pions in the final state

Author: J. R. Wilson, Jochen Steinmann, T. Koga, D. Cherdack, S. Valder, C. McGrew, Y. Hayato, C. Andreopoulos, A. Longhin, A. Shaykina, T. Vladisavljevic, Yoshikazu Yamada, Thorsten Lux, M. Gonin, L. Molina Bueno, F. Bench, W. G. S. Vinning, E. Kearns, A. T. Suzuki, M. Pavin, S. J. Jenkins, T. V. Ngoc, A. Knox, J. F. Martin, C. Alt, T. Sekiguchi, T. Nakadaira, Hiroyuki Sekiya, F. Nova, T. Tsukamoto, Masashi Yokoyama, Yasunari Suzuki, Keigo Nakamura, R. Fujita, Y. Fukuda, Kendall Mahn, N. T. Hong Van, Hyun-Chul Kim, G. Christodoulou, J. Walker, Y. Takeuchi, Xianguo Lu, A. Mefodiev, K. Niewczas, L. H. V. Anthony, André Rubbia, S. Moriyama, Masayuki Nakahata, C. Pidcott, T. Ishida, Tsuyoshi Nakaya, J. L. Palomino, Y. Uchida, C. K. Jung, A. Cervera, L. Maret, M. Kabirnezhad, T. S. Nonnenmacher, Masato Shiozawa, C. Barry, S. Murphy, L. Ludovici, P. N. Ratoff, T. Kutter, T. Golan, A. Shvartsman, K. Zaremba, Yuki Fujii, S. Bhadra, L. Cook, R. Akutsu, M. Lamoureux, M. Friend, Teppei Katori, Pablo Fernandez, K. Kowalik, N. Chikuma, D. Vargas, C. Pistillo, Atsushi Takeda, J. Dumarchez, J. Schwehr, D. Brailsford, E. Reinherz-Aronis, G. Fiorillo, S. Bolognesi, B. Quilain, V. Palladino, M. M. Khabibullin, Yuichi Oyama, A. Shaikhiev, Alessandro Ruggeri, R.P. Kurjata, O. Drapier, Y. Nakajima, M. McCarthy, S. R. Dennis, S. Suvorov, R. P. Litchfield, C. M. Schloesser, S. Nakayama, J. T. Haigh, F. Di Lodovico, C. Wilkinson, M. Tada, D. J. Payne, Koji Yamamoto, M. Kuze, M. Mezzetto, N. C. Hastings, A. Zykova, K. Sakashita, S. M. Oser, L. Berns, A. Nakamura, L. Pickering, W. C. Parker, D. Coplowe, Yanbin Wang, Y. Nishimura, S. Manly, C. Riccio, K. Abe, Asher Kaboth, Y. Seiya, L. Magaletti, C. Giganti, Jan Kisiel, M. Tzanov, T. Okusawa, T. Kobayashi, J. A. Nowak, C. Yanagisawa, Jungsang Kim, S. Y. Suzuki, A. Chappell, Lars Eklund, Yuta Kato, C. J. Metelko, K. Matsushita, T. Hayashino, R. Fukuda, S. Berkman, M. Zito, Gareth J. Barker, A. Beloshapkin, E. T. Atkin, S. B. Boyd, T. Wachala, Artur F. Izmaylov, G. De Rosa, S. Ban, J. Calcutt, C. Vilela, T. Ishii, N. Dokania, G. A. Fiorentini, A. Konaka, L. Munteanu, Ahmed Ali, W. H. Toki, M. B. Smy, Xiao-yan Li, E. Mazzucato, Yusuke Koshio, F. Shaker, D. Karlen, S. L. Liu, E. Rondio, N. McCauley, C. M. Nantais, J. Morrison, A. Pritchard, K. Porwit, G. Zarnecki, C. Checchia, M. Buizza Avanzini, Vladimir Volkov, Lester D.R. Thompson, B. Jamieson, Shuji Tanaka, J. Holeczek, T. Radermacher, Thomas B. Campbell, K. Nakayoshi, M. Hogan, Yu. Kudenko, A. A. Sztuc, C. Densham, S. Zsoldos, Patrick Dunne, M. Vagins, M. Barbi, A. N. Khotjantsev, P. F. Denner, K. M. Tsui, N. Kukita, M. Licciardi, M. Lawe, H. W. Sobel, T. Feusels, T. Matsubara, K. Iwamoto, M. G. Catanesi, Marco Laveder, J. P. Coleman, A. Gorin, P. Hamacher-Baumann, Takaaki Kajita, K. Yasutome, A. Zalewska, Federico Sanchez, A. Bravar, Vincenzo Berardi, F. J. P. Soler, S. Bienstock, G. Vasseur, V. Paolone, Z. Vallari, K. Wood, E. D. Zimmerman, R. A. Wendell, T. Maruyama, G.D. Barr, S. V. Cao, M. J. Wilking, C. Touramanis, M. Jiang, Antonio Ereditato, N. Yershov, K. Gameil, A. Hiramoto, T. Hasegawa, A. Minamino, C. Jesús-Valls, G. C. Penn, T. Dealtry, K. Mavrokoridis, A. Dabrowska, M. Malek, A. J. Finch, J. Lagoda, H. A. Tanaka, R. J. Wilson, Akitaka Ariga, B. Bourguille, S. Dolan, T. Lindner, Shigeki Aoki, A. Cudd, M. Guigue, V. Matveev, J. C. Nugent, S. King, Y. Awataguchi, P. Paudyal, B. Radics, Alexei Yu. Smirnov, Hidekazu Kakuno, S. Mine, G. Yang, A. K. Ichikawa, K. Nishikawa, S. L. Cartwright, F. Iacob, Jan T. Sobczyk, M. Ziembicki, M. Ikeda, Kimihiro Okumura, S. Roth, J. Kameda, K. Nakamura, J. Zalipska, Hidetoshi Kubo, D. R. Hadley, C. Francois, A. C. Weber, Y. Nagai, Yousuke Kataoka, E. S. Pinzon Guerra, Th. A. Mueller, D. Fukuda, O. V. Mineev, M. Posiadala-Zezula, A. Knight, R. Shah, G. Collazuol, Mark Scott, J. G. Walsh, L. O'Sullivan, R. A. Owen, P. Novella, M. Batkiewicz-Kwasniak, H. M. O'Keeffe, M. Miura, C. Wret, L. Koch, B. A. Popov, L. L. Kormos, Masaki Ishitsuka, M. O. Wascko, M. Yu, C. Bronner, Kate Scholberg, T. Yoshida, Steven C. Johnson, S. Yen, K. S. McFarland, M. Antonova, M. Hartz, H. K. Tanaka, S. Emery-Schrenk, Yuto Ashida, D. Sgalaberna, A. Blondel, A. Rychter, W. Uno, E. Radicioni, D. L. Wark, W. Shorrock, T. Yano, A. D. Marino, Y. Sonoda, P. Jonsson, and L. Labarga
Subjects: Physics, Scattering cross-section, 010308 nuclear & particles physics, 0103 physical sciences, media_common.cataloged_instance, Library science, Christian ministry, Early career, European union, 010306 general physics, 01 natural sciences, media_common
Abstract: We thank the J-PARC staff for superb accelerator performance. We thank the CERN NA61/SHINE Collaboration for providing valuable particle production data. We acknowledge the support of MEXT, Japan; NSERC (Grant No. SAPPJ-2014-00031), the NRC and CFI, Canada; the CEA and CNRS/IN2P3, France; the DFG, Germany; the INFN, Italy; the National Science Centre and Ministry of Science and Higher Education, Poland; the RSF (Grant No. 19-12-00325) and the Ministry of Science and Higher Education, Russia; MINECO and ERDF funds, Spain; the SNSF and SERI, Switzerland; the STFC, UK; and the DOE, USA. We also thank CERN for the UA1/NOMAD magnet, DESY for the HERA-B magnet mover system, NII for SINET4, the WestGrid and SciNet consortia in Compute Canada, and GridPP in the United Kingdom. In addition, participation of individual researchers and institutions has been further supported by funds from the ERC (FP7), “la Caixa” Foundation (ID 100010434, fellowship code LCF/BQ/IN17/11620050), the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska- Curie Grants Agreement No. 713673 and No. 754496, and H2020 Grant No. RISE-GA822070-JENNIFER2 2020 and No. RISE-GA872549-SK2HK; the JSPS, Japan; the Royal Society, UK; French ANR Grant No. ANR-19- CE31-0001; and the DOE Early Career programme, USA.
Published: 2020
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42. Authorship Correction: Understanding and Addressing Variation in Health Care–Associated Infections After Durable Ventricular Assist Device Therapy: Protocol for a Mixed Methods Study

Author: Tessa M.F. Watt, Donald S. Likosky, Min Zhang, P Paul Chandanabhumma, Lourdes Cabrera, Russell J. Funk, Robert L. Kormos, Francis D. Pagani, Keith D. Aaronson, John M. Hollingsworth, Supriya Shore, Carol E. Chenoweth, Michael D. Fetters, and Preeti N. Malani
Subjects: Protocol (science), medicine.medical_specialty, business.industry, medicine.medical_treatment, Computer applications to medicine. Medical informatics, MEDLINE, R858-859.7, General Medicine, Health care associated, Corrigenda and Addenda, Variation (linguistics), Ventricular assist device, medicine, Medicine, Intensive care medicine, business
Published: 2020

43. NMR spectroscopy: the swiss army knife of drug discovery

Author: Reto Horst, Kathleen A. Farley, Jane M. Withka, and Bethany L. Kormos
Subjects: 0301 basic medicine, Models, Molecular, Drug discovery, Chemistry, Fragment-based lead discovery, Molecular Conformation, Computational biology, Nuclear magnetic resonance spectroscopy, 010402 general chemistry, Crystallography, X-Ray, Ligands, 01 natural sciences, Biochemistry, Small molecule, 0104 chemical sciences, High-Throughput Screening Assays, Small Molecule Libraries, Solutions, 03 medical and health sciences, 030104 developmental biology, Drug Design, Drug Discovery, Nuclear Magnetic Resonance, Biomolecular, Spectroscopy, Protein Binding
Abstract: Nuclear magnetic resonance (NMR) spectroscopy has evolved into a powerful tool within drug discovery over the last two decades. While traditionally being used by medicinal chemists for small molecule structure elucidation, it can also be a valuable tool for the identification of small molecules that bind to drug targets, for the characterization of target-ligand interactions and for hit-to-lead optimization. Here, we describe how NMR spectroscopy is integrated into the Pfizer drug discovery pipeline and how we utilize this approach to identify and validate initial hits and generate leads.
Published: 2020

44. Outcomes of the First 1300 Adult Heart Transplants in the United States After the Allocation Policy Change

Author: Gavin Hickey, Thomas G. Gleason, Michael A. Mathier, Ibrahim Sultan, Robert L. Kormos, Mary E. Keebler, and Arman Kilic
Subjects: Adult, Male, medicine.medical_specialty, Time Factors, Tissue and Organ Procurement, Waiting Lists, medicine.medical_treatment, Treatment outcome, Clinical Decision-Making, MEDLINE, Risk Assessment, Risk Factors, Physiology (medical), medicine, Humans, Intensive care medicine, Policy Making, Aged, Heart transplants, Heart transplantation, business.industry, Middle Aged, medicine.disease, United States, Treatment Outcome, Heart failure, Disease Progression, Resource allocation, Heart Transplantation, Female, Cardiology and Cardiovascular Medicine, business
Published: 2020

45. The Preimplantation Psychosocial Evaluation and Prediction of Clinical Outcomes During Mechanical Circulatory Support: What Information Is Most Prognostic?

Author: Mary Amanda, Dew, Jennifer C, Hollenberger, Laura L, Obregon, Gavin W, Hickey, Christopher M, Sciortino, Kathleen L, Lockard, Nicole M, Kunz, Michael A, Mathier, Ravi N, Ramani, Arman, Kilic, Dennis M, McNamara, Marc A, Simon, Mary E, Keebler, and Robert L, Kormos
Subjects: Heart Failure, Male, Time Factors, Heart Transplantation, Humans, Female, Heart-Assist Devices, Middle Aged, Prognosis, Follow-Up Studies, Retrospective Studies
Abstract: Psychosocial evaluations are required for long-term mechanical circulatory support (MCS) candidates, no matter whether MCS will be destination therapy (DT) or a bridge to heart transplantation. Although guidelines specify psychosocial contraindications to MCS, there is no comprehensive examination of which psychosocial evaluation domains are most prognostic for clinical outcomes. We evaluated whether overall psychosocial risk, determined across all psychosocial domains, predicted outcomes, and which specific domains appeared responsible for any effects.A single-site retrospective analysis was performed for adults receiving MCS between April 2004 and December 2017. Using an established rating system, we coded psychosocial evaluations to identify patients at low, moderate, or high overall risk. We similarly determined risk within each of 10 individual psychosocial domains. Multivariable analyses evaluated whether psychosocial risk predicted clinical decisions about MCS use (DT versus bridge), and postimplantation mortality, transplantation, rehospitalization, MCS pump exchange, and standardly defined adverse medical events (AEs).In 241 MCS recipients, greater overall psychosocial risk increased the likelihood of a DT decision (odds ratio, 1.76; P = 0.017); and postimplantation pump exchange and occurrence of AEs (hazard ratios [HRs] ≥ 1.25; P ≤ 0.042). The individual AEs most strongly predicted were cardiac arrhythmias and device malfunctions (HRs ≥ 1.39; P ≤ 0.032). The specific psychosocial domains predicting at least 1 study outcome were mental health problem severity, poorer medical adherence, and substance use (odds ratios and HRs ≥ 1.32; P ≤ 0.010).The psychosocial evaluation predicts not only clinical decisions about MCS use (DT versus bridge) but important postimplantation outcomes. Strategies to address psychosocial risk factors before or soon after implantation may help to reduce postimplantation clinical risks.
Published: 2020

46. Identifying Temporal Relationships Between In-Hospital Adverse Events After Implantation of Durable Left Ventricular Assist Devices

Author: Robert L. Kormos, Laura Seese, Arman Kilic, and Francis D. Pagani
Subjects: Adult, Male, medicine.medical_specialty, Time Factors, Databases, Factual, complications, medicine.medical_treatment, heart failure, 030204 cardiovascular system & hematology, Risk Assessment, Ventricular Function, Left, Prosthesis Implantation, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Risk Factors, Internal medicine, left ventricular assist device, Medicine, Humans, 030212 general & internal medicine, Registries, Renal Insufficiency, Adverse effect, Aged, Retrospective Studies, Original Research, Aged, 80 and over, Cardiovascular Surgery, business.industry, Incidence, Middle Aged, medicine.disease, Treatment Outcome, Ventricular assist device, Heart failure, North America, Cardiology, Female, Heart-Assist Devices, Mortality/Survival, Cardiology and Cardiovascular Medicine, business, Respiratory Insufficiency
Abstract: Background This study evaluated the impact of adverse events (AEs) on the development of subsequent AEs after left ventricular assist device (LVAD) surgery. Methods and Results The INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) was used to identify primary durable LVADs implanted between 2006 and 2016. The temporal relationships between AEs occurring during the index hospitalization were evaluated using separate risk‐adjusted Cox proportional hazard models. LVADs were implanted in 18 763 patients. The strongest positive relationships were renal failure leading to hepatic dysfunction (hazard ratio [HR], 6.62; 95% CI, 5.12–8.54; P P P P P P Conclusions Most in‐hospital AEs after LVAD implantation have a significant association with the development of subsequent AEs, with the most profound impact associated with primary renal or respiratory failure, which are also associated with the lowest 1‐year survival. Targeting the reduction of renal or respiratory failure as the primary AE after LVAD surgery would likely yield the greatest reductions in overall AE burden and subsequent mortality.
Published: 2020

47. Measurement of the muon neutrino charged-current single π+ production on hydrocarbon using the T2K off-axis near detector ND280

Author: Rosario Castillo, B. A. Popov, Alexei Yu. Smirnov, K. Nishikawa, C. K. Jung, M. Ikeda, Masato Shiozawa, L. Ludovici, H. Kakuno, Kate Scholberg, L. Zambelli, Jan T. Sobczyk, S. Bhadra, M. Antonova, D. Hansen, T. Feusels, P. Novella, M. M. Khabibullin, J. C. Nugent, O. Drapier, S. King, E. Kearns, W. G. S. Vinning, M. McCarthy, Masashi Yokoyama, W. Shorrock, N. T. Hong Van, J. Walker, T. V. Ngoc, A. Mefodiev, C. Francois, K. Mavrokoridis, D. R. Hadley, T. Ishida, Tsuyoshi Nakaya, A. D. Marino, A. Hiramoto, T. Hasegawa, S. Tobayama, T. Lou, M. Lawe, J. Harada, H. W. Sobel, J. T. Haigh, Ryuji Tamura, F. Iacob, Gareth J. Barker, F. Nova, A. Shaikhiev, R. G. Calland, S. Bordoni, S. Yamasu, J. Holeczek, T. Radermacher, Thomas B. Campbell, K. Nakamura, P. Hamacher-Baumann, J. P. Coleman, K. Nakayoshi, L. Molina Bueno, A. T. Suzuki, F. Gizzarelli, F. Shaker, T. Tomura, B. Quilain, Vincenzo Berardi, A. Zalewska, Y. Nagai, J. F. Martin, N. D. Patel, F. J. P. Soler, Marco Laveder, T. Nakadaira, S. Valder, T. Shirahige, E. Radicioni, M. Ziembicki, J. Zalipska, J. Insler, F. Sanchez, Shin Sasaki, R. M. Berner, Yufeng Wang, K. Sakashita, S. M. Oser, S. Bienstock, J. L. Palomino, G. Vasseur, L. Berns, M. Posiadala-Zezula, T. Inoue, S. Zsoldos, T.S. Nonnenmacher, A. Ali, K. Iwamoto, Y. Nishimura, D. Shaw, W. H. Toki, Y. Takeuchi, A. Blondel, A. Rychter, Y. Kataoka, Akitaka Ariga, Ko Okumura, L. Pickering, G. Fiorillo, M. Hartz, M. Barbi, Alyssa Garcia, B. Bourguille, T. Kajita, K. Zaremba, P. Stowell, S. Mine, K. M. Tsui, Shigeki Aoki, C. Alt, Yutaka Nakajima, D. Karlen, Atsushi Takeda, G. Yang, S. V. Cao, L. Maret, K. Yasutome, Yoshihiro Suzuki, V. Matveev, A. Bravar, S. L. Liu, P. N. Ratoff, Alessandro Ruggeri, N. Kukita, M. Licciardi, W. Uno, M. Lamoureux, T. Thakore, T. Kutter, T. Matsubara, Hidetoshi Kubo, A. C. Weber, C. Touramanis, M. Friend, M. Jiang, Antonio Ereditato, N. Yershov, Y. Petrov, C. Wilkinson, T. Maruyama, S. Ban, T. Wachala, K. Kowalik, Teppei Katori, M. Hogan, G.D. Barr, G. Collazuol, N. Chikuma, Mark Scott, S. Berkman, T. Ishii, N. Dokania, P. P. Koller, A. Minamino, S. Bolognesi, C. Jesús-Valls, N. McCauley, M. Malek, J. Morrison, T. Golan, V. Paolone, T. Yano, Yoshikazu Yamada, Z. J. Liptak, Y. Awataguchi, Z. Vallari, C. W. Walter, Patrick Dunne, A. Shvartsman, W. Y. Ma, H. J. Kim, A. Pritchard, Yuki Fujii, A. N. Khotjantsev, E. D. Zimmerman, S. J. Jenkins, Todd D. Stewart, M. J. Wilking, Pablo Fernandez, D. Vargas, M. A. M. Rayner, G. Zarnecki, P. F. Denner, A. Knox, J. Dumarchez, J. Schwehr, T. Sekiguchi, M. Buizza Avanzini, Hiroyuki Sekiya, R. Fujita, F. Bench, C. Pistillo, B. Jamieson, Y. Fukuda, Kendall Mahn, Keigo Nakamura, D. Coplowe, D. Brailsford, K. Gameil, Y. Sonoda, C. J. Densham, L. Cook, I. Lamont, A. Cervera, C. Nielsen, M. Kabirnezhad, G. C. Penn, T. Hayashino, R. Fukuda, A. Dabrowska, S. R. Dennis, T. Koga, Per Jönsson, C. M. Schloesser, Shuji Tanaka, Davide Sgalaberna, T. Okusawa, R. Akutsu, Y. Seiya, D. Cherdack, M. R. Vagins, S. Y. Suzuki, K. Abe, C. McGrew, S. Dolan, T. Lindner, L. Koch, Y. Hayato, C. Andreopoulos, A. Cudd, A. C. Kaboth, T. Vladisavljevic, J. Y. Kim, E. Mazzucato, Thorsten Lux, Seiko Hirota, M. Gonin, Y. Ashida, W. Oryszczak, K. S. Wood, G. Christodoulou, M. Mezzetto, M. Zito, Y. Nakanishi, S. Moriyama, Yuichi Oyama, S. Suvorov, R. P. Litchfield, Masayuki Nakahata, C. Pidcott, Y. Uchida, M. Tzanov, C. J. Metelko, A. Longhin, A. Shaykina, Giovanni Fiorentini, K. Matsushita, Yu. Kudenko, E. T. Atkin, A. Beloshapkin, R. A. Intonti, G. De Rosa, Koji Yamamoto, M. Pavin, J. Calcutt, Masaki Ishitsuka, A. Konaka, L. Munteanu, Yusuke Koshio, Leïla Haegel, Takahiro Hiraki, O. V. Mineev, James R. Wilson, Yusuke Suda, C. Vilela, R. Shah, E. Rondio, R. A. Owen, A. Gorin, M. Batkiewicz-Kwasniak, M. Miura, C. Wret, C. M. Nantais, K. E. Duffy, H.A. Tanaka, S. Murphy, Xianguo Lu, M. Yu, J. M. Poutissou, C. Bronner, K. Niewczas, M. Guigue, P. Paudyal, J. Walsh, J. P. Lopez, J. Imber, L. H. V. Anthony, André Rubbia, S. L. Cartwright, K. Huang, K. Porwit, S. Manly, Xiao-yan Li, L. L. Kormos, W. Parker, P. Przewlocki, P. Lasorak, S. Martynenko, David A. Wark, J. Lagoda, R. J. Wilson, C. Checchia, Vladimir Volkov, A. Nakamura, Lester D.R. Thompson, R. Tacik, D. Fukuda, C. Riccio, M. G. Catanesi, L. O'Sullivan, T. Yoshida, K. S. McFarland, Jan Kisiel, L. Labarga, T. Kobayashi, H. K. Tanaka, A. Zykova, J. Amey, Alexander Finch, T. Dealtry, A. Missert, B. Radics, P. Martins, F. Di Lodovico, M. Tada, D. J. Payne, M. Kuze, N. C. Hastings, Steven C. Johnson, S. Nakayama, R. A. Wendell, S. Yen, S. Emery-Schrenk, T. Tsukamoto, A. K. Ichikawa, S. Roth, J. Kameda, Y. Azuma, E. S. Pinzon Guerra, Th. A. Mueller, A. Knight, J. Steinmann, H. M. O'Keeffe, T. Ovsyannikova, M. O. Wascko, C. Barry, B. Rossi, C. Yanagisawa, L. Magaletti, C. Giganti, V. Palladino, J. A. Nowak, E. Iwai, A. Chappell, A. A. Sztuc, E. Reinherz-Aronis, E. Scantamburlo, R.P. Kurjata, F. Hosomi, M. B. Smy, Lars Eklund, Yuta Kato, A. Hillairet, L. N. Machado, S. B. Boyd, and Artur F. Izmaylov
Subjects: Physics, Muon, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, 7. Clean energy, 01 natural sciences, Nuclear physics, Cross section (physics), Pion, 0103 physical sciences, High Energy Physics::Experiment, Muon neutrino, Production (computer science), Neutrino, Nuclear Experiment, 010306 general physics, Nucleon, Charged current
Abstract: We report the measurements of single and double differential cross section of muon neutrino charged-current interactions on carbon with a single positively charged pion in the final state at the T2K off-axis near detector using $5.56\times10^{20}$ protons on target. The analysis uses data control samples for the background subtraction and the cross section signal, defined as a single negatively charged muon and a single positively charged pion exiting from the target nucleus, is extracted using an unfolding method. The model dependent cross section, integrated over the T2K off-axis neutrino beam spectrum peaking at $0.6$~GeV, is measured to be $\sigma = (11.76 \pm 0.44 \text{(stat)} \pm 2.39 \text{(syst)}) \times 10^{-40} \text{cm}^2$~$\text{nucleon}^{-1}$. Various differential cross sections are measured, including the first measurement of the Adler angles for single charged pion production in neutrino interactions with heavy nuclei target.
Published: 2020
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48. Measurement of neutron-proton capture in the SNO+ water phase

Author: K. Frankiewicz, C. Grant, A. LaTorre, M. Nirkko, Joshua R. Klein, G. Prior, C. J. Virtue, P. M. Rost, H. M. O'Keeffe, A. Reichold, D. Chauhan, T. Zhang, Mark Guy Boulay, J. Grove, I. Lam, S. Riccetto, N. McCauley, Y. Zhang, P. Khaghani, I. Semenec, F. Shaker, A. Mastbaum, R. D. Martin, V. Fischer, T. Kaptanoglu, A. S. Inácio, L. L. Kormos, J. Wang, J. Dittmer, Jonathan G. C. Veinot, C. B. Krauss, B. Liggins, L. J. Nolan, M. Rigan, K. Gilje, Robert Svoboda, D. Gooding, R. L. Helmer, B. J. Land, S. C. Walton, Kai Zuber, S. D. Biller, Y. Liu, M. A. Cox, S. Maguire, P. J. Harvey, L. Tian, S. Manecki, Jan J. Weigand, A. Zummo, I. Lawson, A. Maio, A. Wright, A. Bialek, G. D. Orebi Gann, J. Rose, E. J. Leming, E. Falk, E. J. Callaghan, A. Li, M. I. Stringer, B. Krar, L. Lebanowski, R. Van Berg, R. Bayes, B. Hreljac, B. T. Cleveland, J. P. Yanez, P. Woosaree, J. Paton, C. J. Jillings, M. Smiley, F. Barao, L. Pickard, M. L. Chen, P. Mekarski, E. Vázquez-Jáuregui, E. Blucher, F. Di Lodovico, O. Chkvorets, M. Luo, B. Tam, M. J. Parnell, D. J. Auty, E. Turner, T. Kroupova, N. Fatemighomi, V. Lozza, Sofia Andringa, I. Morton-Blake, S. J. M. Peeters, A. L. Hallin, R. Ford, M. Askins, E. W. Beier, A. D. Earle, J. Caravaca, J. Rumleskie, W. J. Heintzelman, E. Caden, J. C.L. Tseng, C. Kraus, J. Hu, E. Marzec, J. Maneira, C. Mills, R. Knapik, R. Bonventre, S. Hans, J. Lidgard, A. S. M. Hussain, Richard Rosero, E. Fletcher, A. B. McDonald, K. Singh, Munish K. Sharma, M. R. Anderson, R. Richardson, J. R. Wilson, T. Pershing, M. M. Depatie, J. Hartnell, N. Barros, Martin Ward, M. Meyer, D. Hallman, Minfang Yeh, D. Horne, P. Skensved, S. Nae, and Y. H. Lin
Subjects: Physics - Instrumentation and Detectors, Proton, Hydrogen, Cherenkov detector, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, Analytical chemistry, chemistry.chemical_element, FOS: Physical sciences, 01 natural sciences, 7. Clean energy, law.invention, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), law, 0103 physical sciences, Neutron detection, Neutron, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, Cherenkov radiation, Physics, 010308 nuclear & particles physics, Detector, Instrumentation and Detectors (physics.ins-det), Neutron capture, chemistry
Abstract: The SNO+ experiment collected data as a low-threshold water Cherenkov detector from September 2017 to July 2019. Measurements of the 2.2-MeV $\gamma$ produced by neutron capture on hydrogen have been made using an Am-Be calibration source, for which a large fraction of emitted neutrons are produced simultaneously with a 4.4-MeV $\gamma$. Analysis of the delayed coincidence between the 4.4-MeV $\gamma$ and the 2.2-MeV capture $\gamma$ revealed a neutron detection efficiency that is centered around 50% and varies at the level of 1% across the inner region of the detector, which to our knowledge is the highest efficiency achieved among pure water Cherenkov detectors. In addition, the neutron capture time constant was measured and converted to a thermal neutron-proton capture cross section of $336.3^{+1.2}_{-1.5}$ mb. info:eu-repo/semantics/publishedVersion
Published: 2020
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49. Measurement of the charged-current electron (anti-)neutrino inclusive cross-sections at the T2K off-axis near detector ND280

Author: M. Gonin, Lars Eklund, C. Bronner, T. Vladisavljevic, E. Rondio, N. McCauley, C. M. Nantais, Thorsten Lux, K. Porwit, A. Eguchi, C. Touramanis, M. Jiang, Antonio Ereditato, N. Yershov, M. McCarthy, T. Lindner, T. Kikawa, Kevin Scott McFarland, S. Suvorov, R. P. Litchfield, S. Ban, M. Barbi, P. Hamacher-Baumann, L. Molina Bueno, B. Radics, B. Bourguille, A. Mefodiev, Vladimir Volkov, S. R. Johnson, J. Morrison, J. McElwee, C. E. R. Naseby, Lester D.R. Thompson, M. Mezzetto, N. Dokania, S. M. Oser, G. Pintaudi, Y. Ashida, A. Gorin, M. Ikeda, K. Nakayoshi, Kimihiro Okumura, M. J. Wilking, C. Alt, N. Teshima, A. T. Suzuki, Y. Nagai, Y. Fukuda, G. Christodoulou, P. B. Jurj, G. Zarnecki, M. Buizza Avanzini, F. Iacob, L. Berns, T. Towstego, S. Murphy, S. Bolognesi, C. K. Jung, B. Quilain, J. Kameda, T. Okusawa, Alexander N. Smirnov, K. Nakamura, K. Sakashita, M. Kuze, G.D. Barr, K. Niewczas, M. M. Khabibullin, R. Wendell, Y. Tanihara, Th. A. Mueller, N. Kukita, M. Licciardi, T. Feusels, T. Hayashino, R. Fukuda, C. Wilkinson, C. Giganti, S. Kuribayashi, R. Akutsu, M. Vagins, M. Yu, T. Kobata, S. Mine, D. Brailsford, T. Radermacher, A. Bubak, K. Iwamoto, A. Knox, T. Arihara, Y. Hayato, L. Ludovici, S. Parsa, J. Steinmann, T. Honjo, Y. Nakajima, G. Fiorillo, Hiroyuki Sekiya, F. Nova, Y. Oyama, Hyun-Chul Kim, V. Paolone, P. Novella, Jaroslaw Pasternak, K. Mavrokoridis, Y. Fujii, A. Konaka, J. L. Palomino, R. Fujita, D. Karlen, L. Pickering, C. Ruggles, G. Santucci, S. L. Liu, Z. Vallari, K. Wood, Masayuki Nakahata, C. Pidcott, Y. Uchida, E. D. Zimmerman, E. Mazzucato, A. Takeda, J. C. Nugent, Keigo Nakamura, C. Vilela, Kendall Mahn, A. Rychter, C. Checchia, A. Longhin, M. Friend, A. Shaykina, J. Lagoda, S. R. Dennis, Yoshihiro Suzuki, K. M. Tsui, C. M. Schloesser, Robert Wilson, C. Barry, A. Hiramoto, R.P. Kurjata, Marco Laveder, S. King, A. Izmaylov, A. C. Kaboth, S. P. Kasetti, J. Zalipska, R. Shah, T. Kobayashi, M. G. Catanesi, T. Hasegawa, A. Blondel, D. Sgalaberna, C. Jesús-Valls, Alexander Finch, L. N. Machado, J. Holeczek, Michelangelo Pari, Shuji Tanaka, G. De Rosa, J. G. Walsh, Y. Takeuchi, R. A. Owen, X. Junjie, H. Kikutani, A. Cervera, K. Yamamoto, D. R. Hadley, L. Marti-Magro, F. Bench, K. Zaremba, J. T. Haigh, O. Drapier, S. Yen, D. Cherdack, Y. Kato, S. Valder, A. Pritchard, T. Campbell, Y. Kataoka, M. Batkiewicz-Kwasniak, E. T. Atkin, K. Yasutome, V. A. Matveev, C. Metelko, C. Wret, T. Nakadaira, N. Akhlaq, T. Kajita, M. Lawe, T. Wachala, L. Maret, M. Tani, T. Sekiguchi, Stephanie Bron, C. Riccio, T. Dealtry, K. Abe, C. McGrew, M. Pavin, S. J. Jenkins, L. Koch, M. Guigue, T. Tsukamoto, Akitaka Ariga, D. Coplowe, A. Beloshapkin, M. Miura, F. Di Lodovico, A. A. Sztuc, Federico Sanchez, E. S. Pinzon Guerra, M. Tada, Vincenzo Berardi, G. A. Fiorentini, P. Paudyal, A. Bravar, M. Kabirnezhad, C. Andreopoulos, A. Zykova, W. Toki, Y. Awataguchi, D. Barrow, T. Ishii, P. N. Ratoff, Yu. G. Kudenko, Etam Noah, F. J. P. Soler, T. Kutter, S. L. Cartwright, T. Bonus, N. C. Hastings, D. G. Payne, H. Kubo, A. Nakamura, S. Nakayama, J. Calcutt, Y. Asada, Hiromasa Tanaka, P. Jonsson, Ahmed Ali, M. Hogan, Shigeki Aoki, G. C. Penn, L. Labarga, Alan Cosimo Ruggeri, Y. Nishimura, Gareth J. Barker, M. B. Smy, A. Knight, Y. Seiya, L. Munteanu, H. Sobel, T. Ishida, T. Odagawa, Xiao-yan Li, T. S. Nonnenmacher, S. Bienstock, M. Tajima, Yusuke Koshio, Teppei Katori, L. L. Kormos, H. M. O'Keeffe, E. Radicioni, M. Lamoureux, Y. Sonoda, J. P. Coleman, Laura Gutermuth Anthony, K. Kowalik, S. Zsoldos, S. Roth, C. Pistillo, A. Dabrowska, F. Shaker, T. Matsubara, D. L. Wark, G. Vasseur, V. Palladino, Patrick Dunne, N. Chikuma, J. A. Nowak, W. C. Parker, M. O. Wascko, A. Chappell, E. Kearns, Sy Suzuki, A. N. Khotjantsev, A. K. Ichikawa, J. F. Martin, M. Tzanov, M. Jakkapu, J. R. Wilson, M. Ishitsuka, W. Shorrock, J. Kisiel, Yuuki Nakano, S. Manly, P. F. Denner, A. Minamino, T. Yano, M. Antonova, K. Matsushita, A. D. Marino, R. Okada, T. Ogawa, Y. Katayama, S. Emery-Schrenk, M. Malek, S. Moriyama, Samira Hassani, T. A. Doyle, Jan T. Sobczyk, S. Dolan, C. Densham, A. Cudd, T. Koga, Oleg Mineev, C. Francois, M. Ziembicki, Yufeng Wang, M. Zito, Hidekazu Kakuno, Y. Yamada, G. Yang, S. B. Boyd, N. Izumi, B. A. Popov, B. Jamieson, A. Zalewska, T. Golan, A. Shvartsman, K. Fusshoeller, D. Bravo Berguño, Pablo Fernandez, Kate Scholberg, H. K. Tanaka, D. Vargas, A. C. Weber, J. Dumarchez, J. Schwehr, M. Posiadala-Zezula, G. Collazuol, Mark Scott, T. Yoshida, M. Cicerchia, W. G. S. Vinning, T. Maruyama, T. V. Ngoc, A. Shaikhiev, E. Reinherz-Aronis, K. Nishikawa, Masashi Yokoyama, N. T. Hong Van, J. Walker, Tsuyoshi Nakaya, C. Mauger, Masato Shiozawa, A. Kostin, D. Fukuda, S. Bhadra, L. Cook, L. O'Sullivan, Xianguo Lu, M. Hartz, André Rubbia, L. Magaletti, C. Yanagisawa, S. V. Cao, Ministerio de Economía y Competitividad (España), Abe, K., Akutsu, R., Ali, A., Alt, C., Andreopoulos, C., Anthony, L., Antonova, M., Aoki, S., Ariga, A., Ashida, Y., Atkin, E. T., Awataguchi, Y., Ban, S., Barbi, M., Barker, G. J., Barr, G., Barry, C., Batkiewicz-Kwasniak, M., Beloshapkin, A., Bench, F., Berardi, V., Berkman, S., Berns, L., Bhadra, S., Bienstock, S., Blondel, A., Bolognesi, S., Bourguille, B., Boyd, S. B., Brailsford, D., Bravar, A., Berguno, D. Bravo, Bronner, C., Bubak, A., Avanzini, M. Buizza, Calcutt, J., Campbell, T., Cao, S., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chappell, A., Checchia, C., Cherdack, D., Chikuma, N., Christodoulou, G., Coleman, J., Collazuol, G., Cook, L., Coplowe, D., Cudd, A., Dabrowska, A., De Rosa, G., Dealtry, T., Denner, P. F., Dennis, S. R., Densham, C., Di Lodovico, F., Dokania, N., Dolan, S., Drapier, O., Dumarchez, J., Dunne, P., Eklund, L., Emery-Schrenk, S., Ereditato, A., Fernandez, P., Feusels, T., Finch, A. J., Fiorentini, G. A., Fiorillo, G., Francois, C., Friend, M., Fujii, Y., Fujita, R., Fukuda, D., Fukuda, R., Fukuda, Y., Gameil, K., Giganti, C., Golan, T., Gonin, M., Gorin, A., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Hartz, M., Hasegawa, T., Hastings, N. C., Hayashino, T., Hayato, Y., Hiramoto, A., Hogan, M., Holeczek, J., Hong Van, N. T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishii, T., Ishitsuka, M., Iwamoto, K., Izmaylov, A., Jamieson, B., Jenkins, S. J., Jesus-Valls, C., Jiang, M., Johnson, S., Jonsson, P., Jung, C. K., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Karlen, D., Kasetti, S. P., Kataoka, Y., Katori, T., Kato, Y., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kim, H., Kim, J., King, S., Kisiel, J., Knight, A., Knox, A., Kobayashi, T., Koch, L., Koga, T., Konaka, A., Kormos, L. L., Koshio, Y., Kowalik, K., Kubo, H., Kudenko, Y., Kukita, N., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., Labarga, L., Lagoda, J., Lamoureux, M., Laveder, M., Lawe, M., Licciardi, M., Lindner, T., Litchfield, R. P., Liu, S. L., Li, X., Longhin, A., Ludovici, L., Lu, X., Lux, T., Nascimento Machado, L., Magaletti, L., Mahn, K., Malek, M., Manly, S., Maret, L., Marino, A. D., Martin, J. F., Maruyama, T., Matsubara, T., Matsushita, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., Mccarthy, M., Mccauley, N., Mcfarland, K. S., Mcgrew, C., Mefodiev, A., Metelko, C., Mezzetto, M., Minamino, A., Mineev, O., Mine, S., Miura, M., Bueno, L. Molina, Moriyama, S., Morrison, J., Mueller, Th. A., Munteanu, L., Murphy, S., Nagai, Y., Nakadaira, T., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K. G., Nakamura, K., Nakayama, S., Nakaya, T., Nakayoshi, K., Nantais, C., Ngoc, T. V., Niewczas, K., Nishikawa, K., Nishimura, Y., Nonnenmacher, T. S., Nova, F., Novella, P., Nowak, J., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Okumura, K., Okusawa, T., Oser, S. M., Owen, R. A., Oyama, Y., Palladino, V., Palomino, J. L., Paolone, V., Parker, W. C., Paudyal, P., Pavin, M., Payne, D., Penn, G. C., Pickering, L., Pidcott, C., Guerra, E. S. Pinzon, Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Pritchard, A., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ratoff, P. N., Reinherz-Aronis, E., Riccio, C., Rondio, E., Roth, S., Rubbia, A., Ruggeri, A. C., Rychter, A., Sakashita, K., Sanchez, F., Schloesser, C. M., Scholberg, K., Schwehr, J., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shah, R., Shaikhiev, A., Shaker, F., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Smirnov, A., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Steinmann, J., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Tajima, M., Takeda, A., Takeuchi, Y., Tanaka, H. K., Tanaka, H. A., Tanaka, S., Thompson, L. F., Toki, W., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Uno, W., Vagins, M., Valder, S., Vallari, Z., Vargas, D., Vasseur, G., Vilela, C., Vinning, W. G. S., Vladisavljevic, T., Volkov, V. V., Wachala, T., Walker, J., Walsh, J. G., Wang, Y., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wilson, R. J., Wood, K., Wret, C., Yamada, Y., Yamamoto, K., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yen, S., Yershov, N., Yokoyama, M., Yoshida, T., Yu, M., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zimmerman, E. D., Zito, M., Zsoldos, S., Zykova, A., Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), T2K, Science and Technology Facilities Council (STFC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), and ANR-19-CE31-0001,SUNCORE,Incertitudes systématiques dans les combinaisons de résultats d'oscillations de neutrinos(2019)
Subjects: electron, Physics::Instrumentation and Detectors, Monte Carlo method, far detector, Electron, KAMIOKANDE, antineutrino/mu: secondary beam, Other experiments, antineutrino/e: particle identification, 01 natural sciences, neutrino: flux, High Energy Physics - Experiment, charged current, High Energy Physics - Experiment (hep-ex), secondary beam [neutrino/mu], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], neutrino/e: particle identification, measured [total cross section], detector [neutrino], Charged current, Physics, 0105 Mathematical Physics, J-PARC Lab, Detector, Monte Carlo [numerical calculations], Nuclear & Particles Physics, angular dependence, neutrino: detector, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, Neutrino, numerical calculations: Monte Carlo, Particle Physics - Experiment, scattering [neutrino], Nuclear and High Energy Physics, 530 Physics, Astrophysics::High Energy Astrophysical Phenomena, particle identification [antineutrino/e], FOS: Physical sciences, momentum dependence, secondary beam [antineutrino/mu], Nuclear physics, Momentum, differential cross section: measured, phase space, near detector, measured [differential cross section], 0103 physical sciences, neutrino: scattering, ddc:530, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, 010306 general physics, 0206 Quantum Physics, hep-ex, 010308 nuclear & particles physics, Scattering, particle identification [neutrino/e], background, Computer Science::Information Retrieval, High Energy Physics::Phenomenology, scintillation counter: target, flux [neutrino], neutrino/mu: secondary beam, total cross section: measured, target [scintillation counter], lcsh:QC770-798, High Energy Physics::Experiment, Electron neutrino, experimental results
Abstract: The electron (anti-)neutrino component of the T2K neutrino beam constitutes the largest background in the measurement of electron (anti-)neutrino appearance at the far detector. The electron neutrino scattering is measured directly with the T2K off-axis near detector, ND280. The selection of the electron (anti-)neutrino events in the plastic scintillator target from both neutrino and anti-neutrino mode beams is discussed in this paper. The flux integrated single differential charged-current inclusive electron (anti-)neutrino cross-sections, dσ/dp and dσ/d cos(θ), and the total cross-sections in a limited phase-space in momentum and scattering angle (p > 300 MeV/c and θ ≤ 45°) are measured using a binned maximum likelihood fit and compared to the neutrino Monte Carlo generator predictions, resulting in good agreement., Journal of High Energy Physics, 2020 (10), ISSN:1126-6708, ISSN:1029-8479
Published: 2020
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50. Interpreting Neurologic Outcomes in a Changing Trial Design Landscape: An Analysis of HeartWare Left Ventricular Assist Device Using a Hybrid Intention to Treat Population

Author: M. Jacoski, David A. D'Alessandro, Scott C. Silvestry, Jennifer A Cowger, Robert L. Kormos, Erin Coglianese, Duc Thinh Pham, Nahush A. Mokadam, Claudius Mahr, Muhammad F. Masood, Michael S. Kiernan, and Jeffrey J. Teuteberg
Subjects: medicine.medical_specialty, medicine.medical_treatment, Population, Biomedical Engineering, Biophysics, MEDLINE, Bioengineering, 030204 cardiovascular system & hematology, Brief Communication, law.invention, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Randomized controlled trial, law, medicine, left ventricular assist device, Humans, education, Stroke, Heart Failure, Clinical Trials as Topic, education.field_of_study, Intention-to-treat analysis, business.industry, General Medicine, medicine.disease, Device Usage, advanced heart failure, Intention to Treat Analysis, Clinical trial, Treatment Outcome, 030228 respiratory system, Ventricular assist device, Heart-Assist Devices, business
Abstract: Randomized controlled trials can provide optimal clinical evidence to assess the benefits of new devices, and it is these data that often shape device usage in real-world practice. However, individual clinical trial results sometimes appear discordant for the same device, and alternative devices are sometimes not employed in similar patient populations. To make sound evidence-based decisions, clinicians routinely rely on cross-trial comparisons from different trials of similar but not identical patient populations to assess competing technology when head-to-head randomized comparisons are unavailable.
Published: 2018

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