1. Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery
- Author
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L. I. Sgaramella, A. Pasculli, M. Moschetta, F. Puntillo, P. Dicillo, L. Clemente, M. Maruccia, M. G. Mastropasqua, M. Piombino, N. Resta, G. Rubini, F. P. Prete, G. Serio, L. S. Stucci, G. Giudice, M. Testini, Angela Gurrado, and BCU PoliBa Working Group
- Subjects
Breast cancer ,Breast conserving surgery ,Early complications ,Breast oedema ,Breast seroma ,Post-surgical pain ,Medicine ,Science - Abstract
Abstract Aim of study is to analyze Bromelain’ effects on the most common early complications after BCS (oedema and seroma). From January 2021 to December 2023 a double-blind randomized placebo-controlled trial was performed on 114 candidates for BCS at our Academic Unit. Group A received a supplement of Casperome™—Boswellia Phytosome® + Bromelain (CBB) in combination with alpha-lipoic acid + superoxide dismutase + B and D vitamins + centella asiatica. Group B received a supplement of CBB + placebo. Group C received placebo. The therapies were administrated for 30 days. On GEE logistic regression, drugs combination in A seems to be associated with statistical fewer oedema compared with C (P = 0.018 at 1 day and P = 0.002 after 1 month). Comparing B to C, B gained a significative value after 1 month (P = 0.007). On GEE logistic regression, the drugs combination in A has been associated with statistical fewer seroma compared with C (P = 0.009 at 15thpostoperative day and P
- Published
- 2025
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