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1. Myxoid glioneuronal tumor: Histopathologic, neuroradiologic, and molecular features in a single center series

Author: C. Caporalini, M. Scagnet, L. Giunti, V. Cetica, D. Mei, V. Conti, S. Moscardi, L. Macconi, F. Giordano, L. D'Incerti, L. Genitori, R. Guerrini, and A.M. Buccoliero
Subjects: Myxoid glioneuronal tumor, PDGFRA, Septum pellucidum, Dysembryoplastic neuroepithelial tumors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background: Myxoid glioneuronal tumor (MGT) is a benign glioneuronal neoplasm recently introduced in the World Health Organization (WHO) classification of the central nervous system (CNS) tumors. MGTs are typically located in the septum pellucidum, foramen of Monro or periventricular white matter of the lateral ventricle. They were previously diagnosed as dysembryoplastic neuroepithelial tumors (DNT), showing histological features almost indistinguishable from classical cortical DNT. Despite that, MGTs have been associated with a specific dinucleotide substitution at codon 385 in the platelet-derived growth factor receptor alpha (PDGFRA) gene, replacing a lysine residue with either leucine or isoleucine (p. LysK385Leu/Iso). This genetic variation has never been described in any other CNS tumor. Materials and methods: Thirty-one consecutive tumors, previously diagnosed as DNTs at the Meyer Children's Hospital IRCCS between January 2010 and June 2021 were collected for a comprehensive study of their clinical, imaging, pathological features, and molecular profile. Results: In six out of the thirty-one tumors we had previously diagnosed as DNTs, we identified the recurrent dinucleotide mutation in the PDGFRA. All six tumors were typically located within the periventricular white matter of the lateral ventricle and in the septum pellucidum. We then renamed these lesions as MGT, according to the latest WHO CNS classification. In all patients we observed an indolent clinical course, without recurrence. Conclusion: MGT represent a rare but distinct group of neoplasm with a typical molecular profiling, a characteristic localization, and a relative indolent clinical course.
Published: 2023
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2. Constraining leptonic emission scenarios for the PeVatron candidate HESS J1702-420 with deep XMM-Newton observations

Author: L. Giunti, F. Acero, B. Khélifi, K. Kosack, A. Lemière, R. Terrier, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018), and ANR-17-CE31-0014,PECORA,Rayons Cosmiques au PeV(2017)
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Space and Planetary Science, pulsars: general, FOS: Physical sciences, Astronomy and Astrophysics, gamma rays: general, radiation mechanisms: non-thermal, X-rays: general, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - High Energy Astrophysical Phenomena, methods: data analysis, acceleration of particles
Abstract: The unidentified TeV source HESS J1702-420 has recently been proposed as a new hadronic PeVatron candidate, based on the discovery of a small-scale emission sub-region with extremely hard gamma-ray spectrum up to 100 TeV (named HESS J1702-420A). Given the difficulty to discriminate between a hadronic or leptonic origin of the TeV emission, based on the H.E.S.S. measurement alone, we opted for a multi-wavelength approach. A deep X-ray observation was carried out using the XMM-Newton satellite, with the goal of probing a possible association with a hidden leptonic accelerator. No evidence of a clear counterpart for HESS J1702-420A was found in the X-ray data. After excluding an association with all nearby X-ray point sources, we derived strict upper limits on the diffuse X-ray emission and average magnetic field in the HESS J1702-420A region. We additionally report the serendipitous discovery of a new extended X-ray source, whose association with HESS J1702-420A is not obvious but cannot be ruled out either. A set of scripts dedicated to the multi-wavelength modeling of X-ray and gamma-ray data, based on Gammapy, Naima and Xspec, was developed in the context of this work and is made publicly available along with this paper., Accepted for publication in Astronomy & Astrophysics, 13 pages, 11 figures, 3 tables
Published: 2022

3. P17.13.A Verteporfin inhibits autophagy in glioblastoma cell lines

Author: G Casati, L Giunti, A Iorio, A Marturano, and I Sardi
Subjects: Cancer Research, Oncology, Neurology (clinical)
Abstract: Background Glioblastoma (GBM) is the most common primary brain tumor with a poor prognosis, characterized by a high cellular heterogeneity and invasiveness. Multi-drug resistance (MDR), the blood brain barrier (BEE) and DNA repair systems let the survival of tumor cells, making the treatment with chemo and radiotherapy not effective. Autophagy is a physiological mechanism that allows the recycling of damaged proteins and organelles, in order to protect the correct cell turnover. However, in GBM this process promotes survival and proliferation in stressful conditions such as after a chemo and / or radiotherapy treatment. The Hippo pathway is an extremely important molecular signaling because it is involved in various tumorigenesis processes, for instance the epithelium-mesenchymal transition (EMT), in the increase of stemness, mechanotransduction and chemoresistance. Material and Methods The modulation of autophagy was evaluated in GBM cell lines (U87MG, T98G and A172) exploiting a fluorescent detection that allowed the quantification of the autophagosomal activity present into the cell lines. The rate of autophagy was assessed after the cell lines pharmacological treatment with Hippo pathway inhibitors, Verteporfin 2uM (VP) for 24h, Latrunculin 0,5uM (LAT) for 3h and Cytochalasin 1uM (CIT) for 3h, with Doxorubicin 0,5uM (DOX) for 24h and with the drugs combination (DOX-VP, DOX-LAT and DOX-CIT). Moreover, the expression of the autophagy marker LC3II / I was evaluated in all three GBM cell lines by Western Blotting (WB) experiments. To perform this technique, the cells were treated with DOX and Hippo pathway inhibitors respecting the pharmacological treatment previously used. Then, the proteins were extracted, quantified and finally the WB was performed. Results The results obtained showed that the three GBM cell lines without any drugs were marked by high levels of autophagy, similar to the cells treated with Rapamycin, an autophagy inducer. Moreover, the autophagy rate was definitely reduced after treatment with VP and DOX-VP in all three cell lines, including the chemoresistant T98G. Conversely, the other two Hippo pathway inhibitors (LAT-CIT) and DOX did not significantly change the rate of autophagy. The expression of LC3II / I was particularly low after treatment with VP and DOX-VP in all three cell lines while the other two inhibitors did not significantly change its expression. Conclusion In conclusion, these data demonstrated that the three GBM cell lines (U87MG, T98G and A172) are characterized by high levels of autophagy and the inhibition of the Hippo pathway with VP and especially the combination DOX-VP reduced the activation of this protumoral molecular mechanism in GBM cell lines.
Published: 2022

4. Detection of extended TeV emission around the Geminga pulsar with H.E.S.S

Author: Michael Punch, Christo Venter, Christian Stegmann, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, M. Hörbe, L. Mohrmann, Hassan Abdalla, Albert Seyffert, Michael Backes, Laenita Lorraine Oberholzer, Dieter Horns, K. Nakashima, Tim Holch, K. Bernloehr, Naomi Tsuji, Heinrich J. Völk, Regis Terrier, Carlo Romoli, Gerard Fontaine, Tadayuki Takahashi, M. Fuessling, Hester Schutte, S. Steinmassl, Samuel Timothy Spencer, Sami Caroff, Victor Doroshenko, Frank M. Rieger, Clemens Hoischen, A. A. Zdziarski, P. T. O'Brien, Markus Holler, Q. Remy, Felix Jankowsky, Hannah Dalgleish, German Hermann, Paul Morris, Anne Lemiere, E. Kasai, Louis Du Plessis, Johann van der Walt, Martin Tluczykont, Dan Parsons, Anna Barnacka, D. Malyshev, Nukri Komin, Tom Armstrong, Felix Aharonian, Gilles Maurin, J. F. Glicenstein, David Sanchez, Krzysztof Katarzynski, Victor Barbosa Martins, Ira Jung, C. Arcaro, Sebastian Panny, Gianluca Giavitto, Angel Noel, Bruno Khelifi, Alison Mitchell, Santiago Pita, Werner Hofmann, Gašper Kukec Mezek, Atreyee Sinha, Emma Ona-Wilhelmi, Jonathan Mackey, Carlo van Rensburg, Gerd Puehlhofer, Lei Sun, Laura Olivera-Nieto, Hambeleleni Ndiyavala, Floriane Cangemi, A. Yusafzai, C. Levy, Alexandre Marcowith, Felix Werner, Thomas Lohse, Hend Yassin, Anton Dmytriiev, Manuel Meyer, Arnaud Mares, Manami Sasaki, Mathieu Naurois, Catherine Boisson, Jhilik Majumdar, N. Zywucka, Sumari Hattingh, Takaaki Tanaka, Gavin Rowell, Hector Rueda Ricarte, Mathieu Bony, Oguzhan Anguener, C. Moore, Riaan Steenkamp, Richard White, Kirsty Feijen, Heike Prokoph, Thomas Bylund, Rowan Batzofin, Andreas Zmija, Dorit Glawion, Samuel Zouari, Tomasz Bulik, Robert Brose, Andrea Santangelo, Jacco Vink, Michal Ostrowski, Anna Luashvili, Jacques Muller, Malgorzata Curlo, Marion Spir-Jacob, M. Lemoine-Goumard, Lente Dreyer, David Huber, J.-P. Lenain, Matthieu Renaud, Amid Nayerhoda, Hugh Spackman, Michael Kreter, Justine Devin, Sabrina Casanova, Anu Kundu, Stefan Klepser, V. Sahakian, G. Peron, Alessandro Montanari, Garret Cotter, Vikas Joshi, Zhiqiu Huang, T. Chand, Lott Frans, D. A. Prokhorov, K. Kosack, Sylvia Zhu, P. J. Meintjes, David Berge, Yves Gallant, Lukasz Stawarz, Stefan Ohm, Halim Ashkar, Fabian Leuschner, Jason John Watson, Davit Zargaryan, Arache Djannati-Ataï, Johannes Schaefer, S. J. Fegan, Andreas Quirrenbach, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Stefan Funk, Alicja Wierzcholska, Guillem Marti'i-Devesa, P. Reichherzer, V. Poireau, Jimmy N.S. Shapopi, Jaqueline Catalano, Stefano Gabici, Ramin Marx, M. Panter, Michael Zacharias, Jim Hinton, Jean-Pierre Ernenwein, U. Katz, G. Lamanna, R. Konno, Isak Delberth Davids, Fabian Schüssler, A. Fiasson, Sabrina Einecke, Iryna Lypova, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Roberta Zanin, Emmanuel Moulin, Andrew Taylor, B. Rudak, Kathrin Egberts, Johannes Veh, J. Bolmont, Faical Ait-Benkhali, Kleopas Shiningayamwe, Jacek Niemiec, G. Vasileiadis, Monica Barnard, Yvonne Becherini, Denys Malyshev, Maria Haupt, Olaf Reimer, Edna Ruiz Velasco, Lenka Tomankova, Sébastien Le Stum, Thomas Murach, Christopher van Eldik, Rafal Moderski, Mohanraj Senniappan, Francois Brun, P. Vincent, Heiko Salzmann, Andreas Specovius, Yu Wun Wong, Vincent Marandon, Hannes Thiersen, Vardan Baghmanyan, Celine Armand, Dmitriy Kostunin, L. Giunti, Brian van Soelen, Thomas Tavernier, Markus Boettcher, Michelle Tsirou, M.-H. Grondin, Rachel Simoni, Anita Reimer, Constantin Steppa, Ullrich Schwanke, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Brian Reville, Connor Duffy, James Davies, R. J. Tuffs, B. Bi, Mischa Breuhaus, Pauline Chambery, Marek Jamrozy, Helene Sol, Paolo Marchegiani, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and H.E.S.S.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Astrophysics::High Energy Astrophysical Phenomena, Gamma rays, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, imaging, Astronomy, IACT, Cosmology, Tellurium compounds, Cherenkov counter, gamma ray: emission, Pulsar, HESS, Milagro, TeV, HESS - Abteilung Hinton, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - High Energy Astrophysical Phenomena, HAWC, Cosmic rays, Cherenkov radiation, pulsar
Abstract: Highly extended gamma-ray emission around the Geminga pulsar was discovered by Milagro and verified by HAWC. Despite many observations with Imaging Atmospheric Cherenkov Telescopes (IACTs), detection of gamma-ray emission on angular scales exceeding the IACT field-of-view has proven challenging. Recent developments in analysis techniques have enabled the detection of significant emission around Geminga in archival data with H.E.S.S.. In 2019, further data on the Geminga region were obtained with an adapted observation strategy. Following the announcement of the detection of significant TeV emission around Geminga in archival data, in this contribution we present the detection in an independent dataset. New analysis results will be presented, and emphasis given to the technical challenges involved in observations of highly extended gamma-ray emission with IACTs., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference
Published: 2022

5. Limits on primordial black hole evaporation from H.E.S.S. observations

Author: Hannah Dalgleish, Michael Punch, Samuel Timothy Spencer, Stefan Ohm, Stefan Klepser, M. Fuessling, Constantin Steppa, Markus Holler, Q. Remy, Felix Jankowsky, Alessandro Montanari, Stefano Gabici, Felix Aharonian, Dan Parsons, S. Steinmassl, Sami Caroff, Gianluca Giavitto, Sumari Hattingh, Takaaki Tanaka, Ramin Marx, M. Panter, Laura Olivera-Nieto, A. Yusafzai, M.-H. Grondin, U. Katz, N. Zywucka, Alison Mitchell, Krzysztof Katarzynski, Catherine Boisson, J. Bolmont, Victor Barbosa Martins, Ullrich Schwanke, P. T. O'Brien, Jhilik Majumdar, Markus Boettcher, Faical Ait-Benkhali, Dieter Horns, C. Arcaro, Floriane Cangemi, V. Poireau, Jimmy N.S. Shapopi, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Clemens Hoischen, A. A. Zdziarski, Carlo van Rensburg, Albert Seyffert, Justine Devin, Gavin Rowell, G. Vasileiadis, Johann van der Walt, V. Sahakian, K. Nakashima, Sébastien Le Stum, Denys Malyshev, Regis Terrier, Mathieu Bony, Oguzhan Anguener, Tadayuki Takahashi, Victor Doroshenko, L. Giunti, E. Kasai, Vikas Joshi, Carlo Romoli, Yves Gallant, Frank M. Rieger, Atreyee Sinha, Kirsty Feijen, K. Bernloehr, Samuel Zouari, Andreas Zmija, Christian Stegmann, Michal Ostrowski, Stefan Wagner, J.-P. Lenain, Christo Venter, Hugh Spackman, S. J. Fegan, Andreas Zech, Jason John Watson, Heinrich J. Völk, Jean-Pierre Ernenwein, M. Lemoine-Goumard, Yasunobu Uchiyama, Matthieu Renaud, Mohanraj Senniappan, L. Mohrmann, Lukasz Stawarz, Anton Dmytriiev, German Hermann, Paul Morris, Johannes Veh, Brian Reville, Connor Duffy, James Davies, Stefan Funk, Alicja Wierzcholska, Michelle Tsirou, Michael Kreter, Anne Lemiere, Rachel Simoni, Andreas Quirrenbach, Manami Sasaki, R. J. Tuffs, B. Bi, Guillem Marti'i-Devesa, Jacek Niemiec, M. Hörbe, Andreas Specovius, Andrea Santangelo, Mischa Breuhaus, Pauline Chambery, Olaf Reimer, Michael Zacharias, Emma Ona-Wilhelmi, Martin Tluczykont, Yu Wun Wong, Robert Brose, Michael Backes, Francois Brun, Thomas Lohse, Marek Jamrozy, Jaqueline Catalano, T. Chand, Thomas Murach, Arache Djannati-Ataï, P. Reichherzer, Gašper Kukec Mezek, P. Vincent, Anita Reimer, Laenita Lorraine Oberholzer, Nukri Komin, G. Lamanna, Helene Sol, R. Konno, Monica Barnard, Anna Barnacka, Heiko Salzmann, G. Peron, Vincent Marandon, Hannes Thiersen, Andrew Taylor, Garret Cotter, Tim Holch, Dmitriy Kostunin, Hend Yassin, Isak Delberth Davids, Manuel Meyer, A. Fiasson, Tom Armstrong, Celine Armand, Johannes Schaefer, Roberta Zanin, Zhiqiu Huang, Paolo Marchegiani, Vardan Baghmanyan, Naomi Tsuji, Mathieu Naurois, D. A. Prokhorov, K. Kosack, Gerard Fontaine, Brian van Soelen, David Sanchez, Santiago Pita, Werner Hofmann, Hester Schutte, Hambeleleni Ndiyavala, Gilles Maurin, J. F. Glicenstein, Thomas Tavernier, Kleopas Shiningayamwe, Bruno Khelifi, Edna Ruiz Velasco, Lenka Tomankova, Sabrina Einecke, Iryna Lypova, Yvonne Becherini, Hassan Abdalla, C. Levy, Sylvia Zhu, P. J. Meintjes, David Berge, Richard White, Jacco Vink, Heike Prokoph, Marion Spir-Jacob, David Huber, Amid Nayerhoda, Maria Haupt, Sabrina Casanova, Halim Ashkar, Fabian Leuschner, B. Rudak, Kathrin Egberts, Christopher van Eldik, Rafal Moderski, Anna Luashvili, Lott Frans, Jim Hinton, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Angel Noel, Jonathan Mackey, C. Moore, Dorit Glawion, Davit Zargaryan, Tomasz Bulik, Malgorzata Curlo, Lente Dreyer, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Riaan Steenkamp, Fabian Schüssler, Emmanuel Moulin, Thomas Bylund, Rowan Batzofin, Jacques Muller, Hector Rueda Ricarte, Louis Du Plessis, Anu Kundu, D. Malyshev, Ira Jung, Sebastian Panny, Gerd Puehlhofer, Lei Sun, Alexandre Marcowith, Felix Werner, and Arnaud Mares
Subjects: Physics, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, Gravitational collapse, Evaporation, Order (ring theory), Primordial black hole, Astrophysics, Radiation, Universe, media_common, Hawking radiation
Abstract: Primordial Black Holes are expected to be formed in the early Universe by the gravitational collapse of overdense regions, among other mechanisms. They are also expected to loose their mass over time by the Hawking radiation process. As the rates of this radiation increase with temperature, the PBH evaporation should result in a violent explosion. The current upper limits on explosion rates are on the order of 10$^{4}$ − 10$^{5}$pc$^{-3}$yr$^{-1}$. In this contribution we'll present the results of a search for TeV γ-ray burst within timescale of few seconds, using nearly 5000 hours of H.E.S.S. data. The search algorithm and statistical estimation strategy will be presented as well as cosmological implications of this measurement.
Published: 2022

6. H.E.S.S. ToO program on nearby core-collapse Supernovae : search for very-high energy γ-ray emission towards the SN candidate AT2019krl in M74

Author: German Hermann, Paul Morris, Tadayuki Takahashi, Victor Doroshenko, Ramin Marx, Marek Jamrozy, E. Kasai, Jean-Pierre Ernenwein, Helene Sol, M. Panter, Denys Malyshev, U. Katz, Stefan Klepser, Alessandro Montanari, Markus Boettcher, Jacek Niemiec, Johannes Veh, Olaf Reimer, Regis Terrier, Robert Brose, M.-H. Grondin, Paolo Marchegiani, Matthieu Renaud, Stefan Ohm, Faical Ait-Benkhali, Thomas Murach, Carlo Romoli, Frank M. Rieger, Constantin Steppa, T. Chand, Laura Olivera-Nieto, Mohanraj Senniappan, G. Peron, Stefano Gabici, A. Yusafzai, Garret Cotter, Zhiqiu Huang, D. A. Prokhorov, K. Kosack, Ullrich Schwanke, Johannes Schaefer, Sébastien Le Stum, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Arache Djannati-Ataï, Hannah Dalgleish, P. Reichherzer, Santiago Pita, Justine Devin, Hambeleleni Ndiyavala, Martin Tluczykont, Maria Haupt, J. Bolmont, G. Lamanna, M. Hörbe, Albert Seyffert, Isak Delberth Davids, A. Fiasson, Rachel Simoni, Roberta Zanin, P. T. O'Brien, Samuel Timothy Spencer, Brian Reville, Connor Duffy, C. Levy, James Davies, Dmitriy Kostunin, Gašper Kukec Mezek, Michal Ostrowski, Michael Backes, R. J. Tuffs, B. Bi, J.-P. Lenain, Jaqueline Catalano, Hugh Spackman, Dan Parsons, Halim Ashkar, Fabian Leuschner, Atreyee Sinha, Mathieu Bony, Oguzhan Anguener, S. J. Fegan, Brian van Soelen, N. Zywucka, Mischa Breuhaus, Pauline Chambery, Anton Dmytriiev, Laenita Lorraine Oberholzer, K. Nakashima, Christo Venter, Hend Yassin, Tim Holch, Kirsty Feijen, M. Fuessling, R. Konno, Manami Sasaki, Anna Barnacka, Markus Holler, Q. Remy, Felix Jankowsky, Manuel Meyer, Francois Brun, Andrew Taylor, Vikas Joshi, K. Bernloehr, P. Vincent, Anita Reimer, Krzysztof Katarzynski, Naomi Tsuji, Stefan Funk, Andrea Santangelo, Alicja Wierzcholska, Mathieu Naurois, Thomas Tavernier, Catherine Boisson, Floriane Cangemi, Gerard Fontaine, Anne Lemiere, Felix Aharonian, B. Rudak, V. Poireau, Kathrin Egberts, Jimmy N.S. Shapopi, S. Steinmassl, Sami Caroff, Heiko Salzmann, Hester Schutte, Jhilik Majumdar, Heinrich J. Völk, Andreas Specovius, Lukasz Stawarz, G. Vasileiadis, Richard White, Victor Barbosa Martins, Andreas Zmija, Jacco Vink, M. Lemoine-Goumard, Yu Wun Wong, Alison Mitchell, Jason John Watson, Celine Armand, David Huber, Andreas Quirrenbach, Sabrina Casanova, Emma Ona-Wilhelmi, Michael Kreter, Vincent Marandon, Hannes Thiersen, Guillem Marti'i-Devesa, Nukri Komin, Tom Armstrong, L. Giunti, Vardan Baghmanyan, Michael Zacharias, Christian Stegmann, Thomas Lohse, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, L. Mohrmann, Carlo van Rensburg, C. Arcaro, Christopher van Eldik, Samuel Zouari, Rafal Moderski, V. Sahakian, David Sanchez, Gavin Rowell, Michelle Tsirou, Yves Gallant, Kleopas Shiningayamwe, Werner Hofmann, Sabrina Einecke, Edna Ruiz Velasco, Iryna Lypova, Yvonne Becherini, Lenka Tomankova, Heike Prokoph, Monica Barnard, Marion Spir-Jacob, Amid Nayerhoda, Gilles Maurin, J. F. Glicenstein, Sylvia Zhu, P. J. Meintjes, David Berge, Bruno Khelifi, Jim Hinton, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Hassan Abdalla, Davit Zargaryan, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Fabian Schüssler, Emmanuel Moulin, Gianluca Giavitto, Ira Jung, Sebastian Panny, Louis Du Plessis, Sumari Hattingh, Gerd Puehlhofer, Lei Sun, Thomas Bylund, Rowan Batzofin, Takaaki Tanaka, Alexandre Marcowith, Felix Werner, Jacques Muller, Anna Luashvili, Stuart Ryder, Lott Frans, Arnaud Mares, Hector Rueda Ricarte, Angel Noel, Jonathan Mackey, C. Moore, Dorit Glawion, D. Malyshev, Tomasz Bulik, Riaan Steenkamp, Malgorzata Curlo, Lente Dreyer, Anu Kundu, Michael Punch, Dieter Horns, Clemens Hoischen, A. A. Zdziarski, and Johann van der Walt
Subjects: Core (optical fiber), Physics, Supernova, High energy, Gamma ray, Collapse (topology), Astrophysics
Abstract: While the youngest known supernova remnants (SNRs), such as Cassiopeia A (Cas A), have been proven to be able to accelerate cosmic rays (CRs) only up to ∼ 10$^{14}$ eV at their present evolutionary stages, recent studies have shown that particle energies larger than a few PeV (10$^{15}$ eV) could be reached during the early stages of a core-collapse Supernova (cc-SN), when the high-velocity forward shock expands into the dense circumstellar medium (CSM) shaped by the stellar progenitor wind. Such environments, in particular the type IIn SNe whose progenitors may exhibit mass loss rates as high as 10$^{-2}$ M$_{\bigodot}$ yr$^{-1}$, could thus lead to γ-ray emission from $\pi ^{0}$ decay in hadronic interactions, potentially detectable with current Cherenkov telescopes at very-high energies. Such a detection would provide direct evidence for efficient acceleration of CR protons/nuclei in supernovae, and hence new insights on the long-standing issue of the origin of Galactic Cosmic Rays. In that context, the High Energy Stereoscopic System (H.E.S.S.) has been carrying out a Target of Opportunity program since 2016 to search for such an early very-high-energy γ-ray emission towards nearby core-collapse supernovae and supernova candidates (up to ∼ 10 Mpc), within a few weeks after discovery. After giving an overview of this H.E.S.S. Target of Opportunity program, we present the results obtained from the July 2019 observations towards the transient AT2019krl, originally classified as a type IIn supernova, which occurred in the galaxy M74 at ∼ 9.8 Mpc. Although its nature still remains unclear, the derived H.E.S.S. constraints on this transient are placed in the general context of the expected VHE γ-ray emission from core-collapse supernovae.
Published: 2022

7. TeV Emission of Galactic Plane Sources with HAWC and H.E.S.S

Author: Nicola Omodei, Sebastian Panny, A. Sandoval, Q. Piel, S. Raab, Arturo Iriarte, Kirsty Feijen, R. D. Parsons, Michael Newbold, J. Zorn, Michael Schneider, Fernando Garfias, D. Huber, Christo Venter, Jacek Niemiec, Arnaud Mares, Frank M. Rieger, Thomas Weisgarber, A. Dmytriiev, Olaf Reimer, A. Zech, E. Ruiz-Velasco, Thomas Bylund, Y. A. Gallant, David Sánchez, R. López-Coto, Jorge Cotzomi, Jacques Muller, H. León Vargas, Alison Peisker, Justine Devin, Thomas Murach, P. Morris, Harm Schoorlemmer, Jonathan Mackey, Andrea Albert, Samuel Zouari, Pascal Vincent, M. Zacharias, Stefan Ohm, S. Pita, Tadayuki Takahashi, Gilgamesh Luis-Raya, A. Yusafzai, Andreas Quirrenbach, Samuel Timothy Spencer, Stefano Gabici, Regis Terrier, Victor Doroshenko, L. Nellen, Włodek Kluźniak, R. Noriega-Papaqui, E. Kasai, C. Moore, L. Oakes, J. Bolmont, Michal Ostrowski, J.-P. Lenain, Pooja Surajbali, William H. Lee, L. Olivera-Nieto, E. Moulin, Tomasz Bulik, Rhiannon Turner, Lente Dreyer, O. Martinez, Stefan Klepser, Alessandro Montanari, D. J. van der Walt, Fernando Ureña-Mena, J. P. Harding, César Alvarez, Michael DuVernois, A.M. Taylor, J. C. Arteaga-Velézquez, Connor Duffy, Davit Zargaryan, R. J. White, Stefan Funk, Alicja Wierzcholska, Dmitriy Kostunin, J. Damascene Mbarubucyeye, R. Rauth, Maria Magdalena González, Kristi Engel, A. Galván-Gámez, Christoph Deil, Krzysztof Katarzynski, F. Eichhorn, Mohanraj Senniappan, E. Moreno, Michael Punch, Axel Donath, B. Hona, A. W. Chen, S. Steinmassl, Sami Caroff, Domenico Tiziani, D. Malyshev, Catherine Boisson, M. Panter, Mora Durocher, U. Katz, Pedro Miranda-Romagnoli, C. Arcaro, H. Zhou, Michael Backes, S. Coutiño de León, Ernesto Belmont-Moreno, M. de Bony de Lavergne, R. Brose, Petra Hüntemeyer, C. Levy, Francois Brun, R. J. Tuffs, B. Bi, Andreas Specovius, Joachim Hahn, K. P. Arunbabu, Riaan Steenkamp, Gavin Rowell, P. Reichherzer, James E. M. Watson, M. Bryan, E. de Oña Wilhelmi, Łukasz Stawarz, C. van Rensburg, Pierre Brun, Brenda Dingus, V. Marandon, J. A. Morales-Soto, M. Büchele, H. Prokoph, C. De León, A. Marcowith, V. Baghmanyan, J. Schäfer, Nu. Komin, Tim Holch, Q. Remy, H. M. Schutte, Isak Delberth Davids, A. Fiasson, Jean-Pierre Ernenwein, Hassan Abdalla, S. Hernandez, Jim Hinton, V. Sahakian, E. De la Fuente, F. Werner, Mischa Breuhaus, Luis Villaseñor, Yu Wun Wong, Hambeleleni Ndiyavala, D. Avila Rojas, G. Lamanna, K. S. Caballero-Mora, Roberta Zanin, G. Emery, Halim Ashkar, Fabian Leuschner, Heiko Salzmann, A. S. Seyffert, Kwok Lung Fan, M. Hörbe, T. Tavernier, Nissim Illich Fraija, P. T. O'Brien, Johannes Veh, S. Sailer, Dmitry Khangulyan, Gilles Maurin, S. J. Fegan, A. Djannati-Ataï, D. Jankowsky, J. Dyks, Celine Armand, M. Füßling, R. Marx, Dieter Horns, M. Tluczykont, F. Ait Benkhali, J. F. Glicenstein, M. U. Nisa, Marek Jamrozy, Clemens Hoischen, A. A. Zdziarski, A. Jardin-Blicq, E. O. Angüner, R. Diaz Hernandez, N. Shafi, Natalia Żywucka, M. de Naurois, Andrea Santangelo, K. Malone, Gwenael Giacinti, L. Sun, M.-H. Grondin, D. Garcia, M. Seglar-Arroyo, B. Khélifi, A. J. Smith, T. Capistrán, B. van Soelen, G. Hermann, Anna Barnacka, D. Gottschall, Anne Lemiere, B. Rudak, Markus Böttcher, K. Tollefson, Jhilik Majumdar, Helene Sol, T. Chand, C. Brisbois, Andreas Zmija, Tom Armstrong, Elijah Willox, Carlo Romoli, Alison Mitchell, R. Torres-Escobedo, Atreyee Sinha, Manuel Meyer, I. Martinez-Castellanos, Zorawar Wadiasingh, A. Priyana Noel, V. Barbosa Martins, C. van Eldik, M. Lemoine-Goumard, M. Tsirou, Michael Kreter, Anna Lia Longinotti, F. Schüssler, Dezhi Huang, Jose Andres Garcia-Gonzalez, Werner Hofmann, Monica Barnard, Juan Carlos Diaz-Velez, V. Poireau, Jimmy N.S. Shapopi, K. Nakashima, José Serna-Franco, G. Peron, Garret Cotter, Jacco Vink, A. Carraminana, Umberto Cotti, Jim Davies, M. A. Kastendieck, Thomas Lohse, K. Kosack, Paolo Marchegiani, Konrad Bernlöhr, Heinrich J. Völk, Sabrina Casanova, Catalina Espinoza, M. Renaud, D. Berge, G. Vasileiadis, F. Salesa Greus, I. Jung-Richardt, Kleopas Shiningayamwe, Gilles Fontaine, J. T. Linnemann, Lenka Tomankova, M. Mostafá, G. Fichet de Clairfontaine, R. Konno, Gianluca Giavitto, V. Joshi, B. Peyaud, G. Pühlhofer, J. A. Goodman, H. Odaka, A. Reimer, R. W. Ellsworth, R. W. Springer, M. Curyło, F. Hueyotl-Zahuantitla, E. G. Pérez-Pérez, Y. Pérez Araujo, A. Nayerhoda, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, David Kieda, L. Mohrmann, Misao Sasaki, Markus Holler, Felix Jankowsky, Felix Aharonian, D. Glawion, Jesús Martínez-Castro, Segev BenZvi, Constantin Steppa, L. Giunti, D. A. Prokhorov, Ullrich Schwanke, L. Rinchiuso, J. A. Matthews, Ibrahim Torres, Rachel Simoni, A. Carosi, K. Egberts, S. Chandra, Ruben Alfaro, Sabrina Einecke, Iryna Lypova, Daniel Rosa-Gonzalez, Yvonne Becherini, M. Fernández Alonso, L. Dirson, G. Martí-Devesa, C. Trichard, Sylvia Zhu, P. J. Meintjes, J. H. E. Thiersen, Marion Spir-Jacob, Maria Haupt, C. D. Rho, Rafal Moderski, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Collaboration, H.E.S.S., and Collaboration, HAWC
Subjects: High-energy astronomy, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, IACT, Field of view, 030226 pharmacology & pharmacy, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Observatory, 0103 physical sciences, High Energy Stereoscopic System, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, media_common, Physics, [PHYS]Physics [physics], Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, Galactic plane, Space and Planetary Science, Sky, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], High energy astrophysics
Abstract: International audience; The High Altitude Water Cherenkov (HAWC) observatory and the High Energy Stereoscopic System (H.E.S.S.) are two leading instruments in the ground-based very-high-energy γ-ray domain. HAWC employs the water Cherenkov detection (WCD) technique, while H.E.S.S. is an array of Imaging Atmospheric Cherenkov Telescopes (IACTs). The two facilities therefore differ in multiple aspects, including their observation strategy, the size of their field of view, and their angular resolution, leading to different analysis approaches. Until now, it has been unclear if the results of observations by both types of instruments are consistent: several of the recently discovered HAWC sources have been followed up by IACTs, resulting in a confirmed detection only in a minority of cases. With this paper, we go further and try to resolve the tensions between previous results by performing a new analysis of the H.E.S.S. Galactic plane survey data, applying an analysis technique comparable between H.E.S.S. and HAWC. Events above 1 TeV are selected for both data sets, the point-spread function of H.E.S.S. is broadened to approach that of HAWC, and a similar background estimation method is used. This is the first detailed comparison of the Galactic plane observed by both instruments. H.E.S.S. can confirm the γ-ray emission of four HAWC sources among seven previously undetected by IACTs, while the three others have measured fluxes below the sensitivity of the H.E.S.S. data set. Remaining differences in the overall γ-ray flux can be explained by the systematic uncertainties. Therefore, we confirm a consistent view of the γ-ray sky between WCD and IACT techniques.
Published: 2021

8. Is PKS 0625-354 another variable TeV active galactic nucleus?

Author: Halim Ashkar, Fabian Leuschner, Gilles Maurin, Riaan Steenkamp, J. F. Glicenstein, Heike Prokoph, Bruno Khelifi, Floriane Cangemi, Michael Punch, Gianluca Giavitto, Anna Luashvili, Lott Frans, Sumari Hattingh, Martin Tluczykont, Marek Jamrozy, Sabrina Einecke, Takaaki Tanaka, Iryna Lypova, Marion Spir-Jacob, Yvonne Becherini, Helene Sol, Rachel Simoni, Davit Zargaryan, Hannah Dalgleish, Jim Hinton, Gašper Kukec Mezek, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Andreas Zmija, Amid Nayerhoda, M. Lemoine-Goumard, Stefan Klepser, Alessandro Montanari, C. Arcaro, S. J. Fegan, Anu Kundu, B. Rudak, T. Chand, Hend Yassin, Michael Kreter, Paolo Marchegiani, Tadayuki Takahashi, Dmitriy Kostunin, Mathieu Bony, Oguzhan Anguener, Fabian Schüssler, Manuel Meyer, Markus Boettcher, Gavin Rowell, Kathrin Egberts, Maria Haupt, Victor Doroshenko, Emmanuel Moulin, Ira Jung, Brian van Soelen, Sebastian Panny, Mathieu Naurois, E. Kasai, Kirsty Feijen, Samuel Timothy Spencer, Dieter Horns, Vikas Joshi, Thomas Tavernier, Johannes Schaefer, Gerd Puehlhofer, Lei Sun, Constantin Steppa, Jacek Niemiec, Hassan Abdalla, Albert Seyffert, Olaf Reimer, Christian Stegmann, Stefan Wagner, Andreas Zech, Alexandre Marcowith, Regis Terrier, Felix Werner, Yasunobu Uchiyama, K. Nakashima, K. Bernloehr, Carlo Romoli, Hector Rueda Ricarte, Lukasz Stawarz, Frank M. Rieger, Thomas Murach, Kleopas Shiningayamwe, Clemens Hoischen, A. A. Zdziarski, Christopher van Eldik, N. Zywucka, Jaqueline Catalano, L. Mohrmann, Monica Barnard, Rafal Moderski, Heinrich J. Völk, Arnaud Mares, Ullrich Schwanke, Stefan Ohm, Thomas Bylund, Rowan Batzofin, Anita Reimer, Andreas Quirrenbach, Edna Ruiz Velasco, Johann van der Walt, Jhilik Majumdar, Guillem Marti'i-Devesa, R. Konno, Jacques Muller, Dan Parsons, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Lenka Tomankova, Stefano Gabici, Andrew Taylor, Michael Zacharias, Christo Venter, Sylvia Zhu, P. J. Meintjes, David Berge, M. Hörbe, Michael Backes, Robert Brose, V. Poireau, Jimmy N.S. Shapopi, V. Sahakian, Krzysztof Katarzynski, Brian Reville, Connor Duffy, Laenita Lorraine Oberholzer, Tim Holch, Anton Dmytriiev, M. Fuessling, Manami Sasaki, G. Vasileiadis, Catherine Boisson, Arache Djannati-Ataï, P. Reichherzer, J. Bolmont, Jason John Watson, D. Malyshev, Andrea Santangelo, Naomi Tsuji, Matthieu Renaud, Denys Malyshev, Isak Delberth Davids, G. Lamanna, James Davies, A. Fiasson, Roberta Zanin, Yves Gallant, S. Steinmassl, Sami Caroff, R. J. Tuffs, Gerard Fontaine, B. Bi, Santiago Pita, Hambeleleni Ndiyavala, Hester Schutte, Justine Devin, Mohanraj Senniappan, C. Levy, Mischa Breuhaus, Pauline Chambery, Andreas Specovius, Jean-Pierre Ernenwein, Yu Wun Wong, Johannes Veh, Vincent Marandon, Hannes Thiersen, Vardan Baghmanyan, Markus Holler, Q. Remy, Felix Jankowsky, Richard White, Felix Aharonian, Jacco Vink, Alison Mitchell, David Huber, Sabrina Casanova, Louis Du Plessis, Angel Noel, Jonathan Mackey, Anna Barnacka, C. Moore, Victor Barbosa Martins, Dorit Glawion, Carlo van Rensburg, Anne Lemiere, Tomasz Bulik, Malgorzata Curlo, Emma Ona-Wilhelmi, Samuel Zouari, Thomas Lohse, Lente Dreyer, Michal Ostrowski, J.-P. Lenain, Hugh Spackman, Stefan Funk, Alicja Wierzcholska, Ramin Marx, M. Panter, U. Katz, Faical Ait-Benkhali, G. Peron, Garret Cotter, Sébastien Le Stum, Zhiqiu Huang, D. A. Prokhorov, K. Kosack, P. T. O'Brien, Atreyee Sinha, Laura Olivera-Nieto, A. Yusafzai, Nukri Komin, Tom Armstrong, David Sanchez, Werner Hofmann, L. Giunti, Michelle Tsirou, Francois Brun, P. Vincent, Heiko Salzmann, Celine Armand, M.-H. Grondin, German Hermann, and Paul Morris
Subjects: Physics, Brightness, Active galactic nucleus, Astrophysics::High Energy Astrophysical Phenomena, Flux, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Viewing angle, Variable (computer science), symbols.namesake, symbols, Spectral energy distribution, Blazar, Doppler effect, Astrophysics::Galaxy Astrophysics
Abstract: The majority of the active galactic nuclei (AGN) detected at very-high-energies above 100 GeV belong to the class of blazars with a small angle between the jet-axis and the line-of-sight. Only about 10 percent of the gamma-ray AGN are objects with a larger viewing angle resulting in a smaller Doppler boosting of the emission. Originally, it was believed that gamma-ray emission can only be observed from blazars and those are variable in its brightness. Instead, the last years have shown that non-blazar active galaxies also show a fascinating variability behaviour which provide important new insights into the physical processes responsible for the gamma-ray production and especially for flaring events. Here, we report on the observation of gamma-ray variability of the active galaxy PKS 0625−354 detected with the H.E.S.S. telescopes in November 2018. The classification of PKS 0625−354 is a still matter of debate. The H.E.S.S. measurements were performed as part of a flux observing program and showed in the first night of the observation a detection of the object with > 5σ. A denser observation campaign followed for the next nine nights resulting in a decrease of the gamma-ray flux. Those observations were accompanied with Swift in the X-ray and UV/optical band allowing for the reconstruction of a multi-band broad-band spectral energy distribution. We will discuss the implications of the gamma-ray variability of the object.
Published: 2021

9. Search for dark matter annihilation towards the inner Milky Way halo with the H.E.S.S. Inner Galaxy Survey

Author: Clemens Hoischen, A. A. Zdziarski, Robert Brose, Johann van der Walt, Halim Ashkar, Fabian Leuschner, Stefan Ohm, L. Giunti, Albert Seyffert, Davit Zargaryan, Stefan Klepser, Alessandro Montanari, K. Nakashima, Gaëtan Fichet de Clairfontaine, Sabrina Einecke, Axel Donath, A. W. Chen, Iryna Lypova, K. Bernloehr, Heinrich J. Völk, Yvonne Becherini, Stefano Gabici, Michelle Tsirou, Anna Luashvili, Vikas Joshi, J. Bolmont, Fabian Schüssler, M.-H. Grondin, Emmanuel Moulin, Andreas Specovius, Kleopas Shiningayamwe, Anne Lemiere, B. Rudak, Lott Frans, Michael Punch, Edna Ruiz Velasco, Sylvia Zhu, P. J. Meintjes, David Berge, Michael Backes, Matthieu Renaud, German Hermann, Paul Morris, Kathrin Egberts, Constantin Steppa, Tadayuki Takahashi, Laenita Lorraine Oberholzer, Tim Holch, Lukasz Stawarz, Louis Du Plessis, Naomi Tsuji, V. Poireau, Jimmy N.S. Shapopi, Victor Doroshenko, Yu Wun Wong, Emma Ona-Wilhelmi, Riaan Steenkamp, E. Kasai, G. Lamanna, Ullrich Schwanke, Gerard Fontaine, Jim Hinton, Victor Barbosa Martins, Thomas Lohse, Frank M. Rieger, Hester Schutte, Carlo van Rensburg, Francois Brun, P. Vincent, Heiko Salzmann, Mathieu Bony, Oguzhan Anguener, Kirsty Feijen, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Ramin Marx, Dmitriy Kostunin, M. Panter, U. Katz, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Jaqueline Catalano, R. Konno, Hector Rueda Ricarte, T. Chand, Samuel Zouari, P. T. O'Brien, M. Hörbe, Celine Armand, Andreas Quirrenbach, Guillem Marti'i-Devesa, Faical Ait-Benkhali, Andrew Taylor, G. Vasileiadis, Vincent Marandon, Brian van Soelen, Marek Jamrozy, Hannes Thiersen, Dieter Horns, Hassan Abdalla, Thomas Bylund, Rowan Batzofin, Sébastien Le Stum, Thomas Tavernier, Gilles Maurin, Floriane Cangemi, Helene Sol, Christian Stegmann, Jacques Muller, Vardan Baghmanyan, Johannes Schaefer, J. F. Glicenstein, Anu Kundu, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, Monica Barnard, L. Mohrmann, Arache Djannati-Ataï, C. Levy, Atreyee Sinha, Bruno Khelifi, Michal Ostrowski, J.-P. Lenain, Hugh Spackman, Michael Zacharias, Regis Terrier, Hannah Dalgleish, P. Reichherzer, Andreas Zmija, Gianluca Giavitto, Jacek Niemiec, M. Lemoine-Goumard, Paolo Marchegiani, Markus Holler, Carlo Romoli, Isak Delberth Davids, Stefan Funk, Alicja Wierzcholska, Olaf Reimer, Q. Remy, Felix Jankowsky, Michael Kreter, Anna Barnacka, Brian Reville, Connor Duffy, A. Fiasson, Roberta Zanin, Thomas Murach, Heike Prokoph, James Davies, Sumari Hattingh, Felix Aharonian, Richard White, Angel Noel, M. Fuessling, R. J. Tuffs, B. Bi, Christo Venter, Takaaki Tanaka, D. Malyshev, Jonathan Mackey, Jacco Vink, Ira Jung, Sebastian Panny, Alison Mitchell, Anita Reimer, David Huber, Sabrina Casanova, Marion Spir-Jacob, Mischa Breuhaus, Pauline Chambery, Gerd Puehlhofer, C. Arcaro, C. Moore, Jhilik Majumdar, Lei Sun, Santiago Pita, Hambeleleni Ndiyavala, S. Steinmassl, Sami Caroff, Anton Dmytriiev, Dorit Glawion, G. Peron, Garret Cotter, Alexandre Marcowith, Felix Werner, Amid Nayerhoda, Manami Sasaki, Tomasz Bulik, Zhiqiu Huang, Malgorzata Curlo, Maria Haupt, Andrea Santangelo, Arnaud Mares, Lente Dreyer, D. A. Prokhorov, K. Kosack, V. Sahakian, Gavin Rowell, Jean-Pierre Ernenwein, N. Zywucka, Denys Malyshev, Markus Boettcher, Yves Gallant, Christopher van Eldik, Rafal Moderski, Johannes Veh, Samuel Timothy Spencer, Mohanraj Senniappan, Rachel Simoni, Dan Parsons, Krzysztof Katarzynski, Catherine Boisson, Justine Devin, Lenka Tomankova, Martin Tluczykont, Gašper Kukec Mezek, Hend Yassin, Manuel Meyer, Mathieu Naurois, Jason John Watson, S. J. Fegan, Nukri Komin, Tom Armstrong, David Sanchez, Werner Hofmann, Laura Olivera-Nieto, and A. Yusafzai
Subjects: Physics, Annihilation, WIMP, Milky Way, Weakly interacting massive particles, media_common.quotation_subject, Dark matter, Astrophysics::Cosmology and Extragalactic Astrophysics, Halo, Astrophysics, Galaxy, Universe, media_common
Abstract: The presence of dark matter (DM) is suggested by a wealth of astrophysical and cosmological measurements. However, its underlying nature is yet unknown. Among the most promising candidates are weakly interacting massive particles (WIMPs): particles with mass and coupling strength at the electroweak scale and thermally produced in the early universe have a present relic density consistent with that observed today. WIMP self-annihilation would produce Standard Model particles including gamma-rays, which have been long-time recognized as a prime messenger to indirectly detect dark matter signals. The centre of the Milky Way is predicted as the brightest source of DM annihilations. The H.E.S.S. collaboration is currently performing a survey of the inner region of the Milky Way, the Inner Galaxy Survey (IGS), intended to achieve the best sensitivity to faint and diffuse emissions in a region of several degrees around the Galactic Centre. We analyzed 2014-2020 observations taken with the five-telescope array to search for a DM annihilation signal. With the current dataset of about 550 hours, we found no significant excess and therefore derived strong constraints on the velocity-weighted annihilation cross-section. TeV thermal WIMPs can be probed in different annihilation channels.
Published: 2021

10. Revealing x-ray and gamma ray temporal and spectral similarities in the GRB 190829A afterglow

Author: K. Egberts, Davit Zargaryan, Axel Donath, A. W. Chen, G. Pühlhofer, M. de Bony de Lavergne, V. Poireau, P. T. O'Brien, P. A. Evans, Riaan Steenkamp, A. Lemiere, F. Eichhorn, Nu. Komin, J. Schäfer, Włodek Kluźniak, A. S. Seyffert, N. Shafi, Natalia Żywucka, Sebastian Panny, R. J. White, Domenico Tiziani, D. Malyshev, T. Chand, Jhilik Majumdar, V. Baghmanyan, Clemens Hoischen, A. A. Zdziarski, Jacco Vink, Alison Mitchell, Joachim Hahn, M. Füßling, C. van Eldik, J.F. Glicenstein, Lei Sun, P. Reichherzer, Jim Davies, A. Carosi, Zorawar Wadiasingh, Q. Remy, Anna Barnacka, A. Djannati-Ataï, A. Montanari, E. Moulin, M. de Naurois, Alexandre Marcowith, Arnaud Mares, Christoph Deil, Sabrina Casanova, Christo Venter, G. Peron, Garret Cotter, M. Hörbe, Dmitriy Kostunin, E. Ruiz-Velasco, Mohanraj Senniappan, Thomas Bylund, E. O. Angüner, S. Raab, Tadayuki Takahashi, F. Brun, R. J. Tuffs, B. Bi, H. Prokoph, C. van Rensburg, A. Zech, J. Muller, Monica Barnard, B. Peyaud, Kirsty Feijen, R. Rauth, Pierre Brun, Victor Doroshenko, Michael Punch, E. Kasai, Konrad Bernlöhr, M. Curyło, Stefano Gabici, Gianluca Giavitto, Frank M. Rieger, Michael Backes, Stefan Klepser, J.-P. Ernenwein, A. Dmytriiev, Mischa Breuhaus, J. Dyks, G. Emery, L. Olivera-Nieto, Tim Holch, S. Fegan, Samuel Zouari, M.-H. Grondin, L. Mohrmann, Stefan Ohm, I. Jung-Richardt, Markus Böttcher, K. Kosack, A. Reimer, G. Hermann, Marek Jamrozy, Regis Terrier, S. Pita, Markus Holler, Felix Jankowsky, Armelle Jardin-Blicq, E. de Ona Wilhelmi, A.M. Taylor, Carlo Romoli, J. Damascene Mbarubucyeye, Hester Schutte, Dieter Horns, Jonathan Mackey, Tom Armstrong, Helene Sol, Sylvia Zhu, P. J. Meintjes, Hambeleleni Ndiyavala, G. Fontaine, H. Odaka, Felix Aharonian, V. Barbosa Martins, Andreas Specovius, Michal Ostrowski, Johannes Veh, D. J. van der Walt, Yu Wun Wong, L. Oakes, C. Moore, J. Bolmont, D. Jankowsky, M. Seglar-Arroyo, Paolo Marchegiani, Rachel Simoni, R. Marx, S. Steinmassl, D. Glawion, Łukasz Stawarz, Manuel Meyer, Tomasz Bulik, Lente Dreyer, Andreas Quirrenbach, Sabrina Einecke, Iryna Lypova, Constantin Steppa, D. A. Prokhorov, M. Zacharias, Christopher J. Duffy, A. Wierzcholska, M. Tluczykont, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, F. Schüssler, Yvonne Becherini, Jimmy N.S. Shapopi, C. Levy, Werner Hofmann, G. Lamanna, M. A. Kastendieck, James E. M. Watson, Ullrich Schwanke, G. Vasileiadis, Isak Delberth Davids, Misao Sasaki, Bruno Khelifi, M. Büchele, M. Lemoine-Goumard, J. Zorn, Elisabetta Bissaldi, Roberta Zanin, F. Ait Benkhali, L. Rinchiuso, M. Scalici, Y. A. Gallant, J. Devin, Jim Hinton, D. Berge, V. Sahakian, F. Werner, Andrea Santangelo, Stefan Funk, S. Sailer, Dmitry Khangulyan, Michael Kreter, Jacek Niemiec, D. A. Sanchez, A. Priyana Noel, C. Arcaro, Fabian Leuschner, J. H. E. Thiersen, M. Panter, U. Katz, K. Nakashima, Olaf Reimer, G. Martí-Devesa, H. Ashkar, Q. Piel, P. Morris, Gavin Rowell, M. Bryan, Kleopas Shiningayamwe, A. Yusafzai, Thomas Murach, G. Maurin, Maria Haupt, Heinrich J. Völk, M. Renaud, R. D. Parsons, Samuel Timothy Spencer, Lenka Tomankova, T. Tam, G. Fichet de Clairfontaine, A. Sinha, J.-P. Lenain, D. Huber, Rafal Moderski, S. Caroff, B. van Soelen, S. Chandra, R. Konno, L. Dirson, M. Tsirou, B. Rudak, V. Joshi, Thomas Lohse, L. Giunti, A. Nayerhoda, Hassan Abdalla, A. Fiasson, M. Spir-Jacob, V. Marandon, K. Katarzyński, P. Vincent, T. Tavernier, K. L. Page, Heiko Salzmann, Celine Armand, Catherine Boisson, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), H.E.S.S., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), H.E.S.S. Collaboration, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: Photon, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: burst, 01 natural sciences, Luminosity, HESS, 0103 physical sciences, High Energy Stereoscopic System, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, energy: high, Multidisciplinary, X-ray: energy spectrum, 010308 nuclear & particles physics, photon, Gamma ray, trigger, Light curve, redshift, Redshift, Afterglow, collapse, gamma ray: VHE, HESS - Abteilung Hinton, spectral, Astrophysics - High Energy Astrophysical Phenomena, Gamma-ray burst, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], absorption
Abstract: An intrinsic gamma-ray burst afterglow Long gamma-ray bursts (GRBs) are emitted by relativistic jets generated during the collapse of a massive star in a distant galaxy. The GRB itself lasts only a few seconds but is followed by an afterglow that can persist for hours or days. The H.E.S.S. Collaboration observed the afterglow of GRB 190829A, a nearby long GRB. The proximity of this burst allowed it to be detected at tera–electron volt energies that would otherwise be absorbed in the intergalactic medium. By analyzing the spectrum and light curve at x-ray and gamma-ray wavelengths, the authors show that the afterglow cannot be explained by standard models. Science , abe8560, this issue p. 1081
Published: 2021

11. Deep observations of Kepler's SNR with H.E.S.S

Author: Jason John Watson, Kleopas Shiningayamwe, Edna Ruiz Velasco, Lenka Tomankova, Martin Tluczykont, Gašper Kukec Mezek, Hend Yassin, Manuel Meyer, Mathieu Naurois, Anton Dmytriiev, Manami Sasaki, Riaan Steenkamp, Andrea Santangelo, T. Chand, Gilles Maurin, J. F. Glicenstein, Jhilik Majumdar, Johannes Schaefer, Christian Stegmann, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, Bruno Khelifi, Anu Kundu, Hector Rueda Ricarte, Davit Zargaryan, Jacek Niemiec, L. Mohrmann, Arache Djannati-Ataï, Albert Seyffert, V. Sahakian, Anna Barnacka, P. Reichherzer, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Ira Jung, Olaf Reimer, G. Peron, Christo Venter, Garret Cotter, Sebastian Panny, K. Nakashima, K. Bernloehr, Isak Delberth Davids, Victor Barbosa Martins, A. Fiasson, Roberta Zanin, Yves Gallant, Fabian Schüssler, Michael Backes, Heinrich J. Völk, Gerd Puehlhofer, Lei Sun, Thomas Murach, Jean-Pierre Ernenwein, Emmanuel Moulin, G. Lamanna, V. Poireau, Jimmy N.S. Shapopi, Alexandre Marcowith, Felix Werner, Laenita Lorraine Oberholzer, Tim Holch, Naomi Tsuji, Carlo van Rensburg, Zhiqiu Huang, D. A. Prokhorov, K. Kosack, Tadayuki Takahashi, Markus Holler, Q. Remy, Felix Jankowsky, Victor Doroshenko, Felix Aharonian, Johannes Veh, Gerard Fontaine, E. Kasai, G. Vasileiadis, M.-H. Grondin, Anne Lemiere, Floriane Cangemi, Arnaud Mares, Samuel Zouari, Denys Malyshev, Alison Mitchell, Samuel Timothy Spencer, Hester Schutte, Stefan Klepser, Andreas Specovius, Alessandro Montanari, Andreas Zmija, Clemens Hoischen, A. A. Zdziarski, M. Lemoine-Goumard, Emma Ona-Wilhelmi, Yu Wun Wong, Stefan Ohm, Dan Parsons, Johann van der Walt, Vikas Joshi, Brian Reville, Connor Duffy, Michael Kreter, Gianluca Giavitto, D. Malyshev, Thomas Lohse, Mohanraj Senniappan, James Davies, Vincent Marandon, Hannes Thiersen, R. J. Tuffs, Hannah Dalgleish, Vardan Baghmanyan, P. T. O'Brien, Stefano Gabici, Thomas Bylund, Krzysztof Katarzynski, Michal Ostrowski, B. Bi, J.-P. Lenain, Catherine Boisson, Hugh Spackman, Michael Punch, Lukasz Stawarz, Sumari Hattingh, Monica Barnard, Jaqueline Catalano, Takaaki Tanaka, Rowan Batzofin, Mischa Breuhaus, Pauline Chambery, Stefan Funk, Alicja Wierzcholska, R. Konno, Ramin Marx, M. Panter, Anna Luashvili, Justine Devin, J. Bolmont, U. Katz, Francois Brun, Richard White, Jacques Muller, Andrew Taylor, P. Vincent, N. Zywucka, Andreas Quirrenbach, Laura Olivera-Nieto, A. Yusafzai, Dieter Horns, Guillem Marti'i-Devesa, Hassan Abdalla, Heiko Salzmann, Jacco Vink, Mathieu Bony, Oguzhan Anguener, Michael Zacharias, Celine Armand, Atreyee Sinha, Marek Jamrozy, Kirsty Feijen, Faical Ait-Benkhali, Lott Frans, Robert Brose, Santiago Pita, Hambeleleni Ndiyavala, L. Giunti, David Huber, German Hermann, Paul Morris, M. Hörbe, Helene Sol, Sabrina Casanova, Jim Hinton, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Sébastien Le Stum, Paolo Marchegiani, Michelle Tsirou, Constantin Steppa, Halim Ashkar, Fabian Leuschner, Ullrich Schwanke, C. Arcaro, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Gavin Rowell, Regis Terrier, B. Rudak, Carlo Romoli, Kathrin Egberts, Nukri Komin, Tom Armstrong, Frank M. Rieger, Matthieu Renaud, M. Fuessling, David Sanchez, Heike Prokoph, C. Levy, S. Steinmassl, Sami Caroff, Werner Hofmann, Marion Spir-Jacob, S. J. Fegan, Amid Nayerhoda, Sylvia Zhu, P. J. Meintjes, David Berge, Maria Haupt, Christopher van Eldik, Rafal Moderski, Dmitriy Kostunin, Brian van Soelen, Thomas Tavernier, Markus Boettcher, Sabrina Einecke, Iryna Lypova, Anita Reimer, Yvonne Becherini, Rachel Simoni, Angel Noel, Jonathan Mackey, C. Moore, Dorit Glawion, Tomasz Bulik, Malgorzata Curlo, Lente Dreyer, Louis Du Plessis, Naurois , Mathieu, Ona-Wilhelmi , Emma, and Bony , Mathieu
Subjects: Astrophysics::High Energy Astrophysical Phenomena, atmosphere [Cherenkov counter], VHE [gamma ray], IACT, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Cherenkov counter: atmosphere, Kepler, HESS, supernova, Astrophysics::Solar and Stellar Astrophysics, ddc:530, High Energy Stereoscopic System, cosmic radiation: acceleration, Supernova remnant, Cherenkov radiation, Astrophysics::Galaxy Astrophysics, Physics, energy: high, Astrophysics::Instrumentation and Methods for Astrophysics, imaging, Galaxy, Cassiopeia A, Supernova, gamma ray: VHE, high [energy], acceleration [cosmic radiation], galaxy
Abstract: 37th International Cosmic Ray Conference, ICRC 2021, Berlin, online, Germany, 12 Jul 2021 - 23 Jul 2021; Proceedings of Science / International School for Advanced Studies (ICRC2021), 805 (2021). doi:10.22323/1.395.0805, Kepler��s supernova remnant (SNR) which is produced by the most recent naked-eye supernova in our Galaxy is one of the best studied SNRs, but its gamma-ray detection has eluded us so far. Observations with modern imaging atmospheric Cherenkov telescopes (IACT) have enlarged the knowledge about nearby SNRs with ages younger than 500 years by establishing Cassiopeia A and Tycho��s SNRs as very high energy (VHE) gamma-ray sources and setting a lower limit on the distance to Kepler��s SNR. This SNR is significantly more distant than the other two and expected to be one of the faintest gamma-ray sources within reach of the IACT arrays of this generation. We report strong evidence for a VHE signal from Kepler��s SNR based on deep observations of the High Energy Stereoscopic System (H.E.S.S.) with an exposure of 152 hours, including 122 hours accumulated in 2017-2020. We further discuss implications of this result for cosmic-ray acceleration in young SNRs., Published by SISSA, Trieste
Published: 2021

12. H.e.s.s. And magic observations of a sudden cessation of a very-high-energy γ -ray flare in PKS 1510-089 in May 2016

Author: A. Yusafzai, J. van Scherpenberg, M. Büchele, B. Boccardi, S. Caroff, S. J. Fegan, Daniela Dorner, T. Schweizer, Mosè Mariotti, Gaia Vanzo, Tom Armstrong, Nu. Komin, Pratik Majumdar, M. V. Fonseca, Matteo Cerruti, A. Lemiere, F. Eichhorn, J. Devin, C. Trichard, Michael Punch, Stefano Gabici, M. Palatiello, V. A. Acciari, F. Schüssler, Sylvia Zhu, P. J. Meintjes, Werner Hofmann, Samuel Timothy Spencer, Y. Kajiwara, J. Zorn, D. Dominis Prester, S. Bonnefoy, Constantin Steppa, G. Maurin, Adrian Biland, J. M. Paredes, Antonio Stamerra, U. Barres de Almeida, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, Davide Depaoli, Dmitriy Kostunin, R. Mirzoyan, T. Surić, D. Gottschall, M. Füßling, Moritz Hütten, Lea Heckmann, M. Gaug, J. Herrera, Ullrich Schwanke, C. Arcaro, H. Abdalla, Lorenzo Bellizzi, Thomas P. Krichbaum, Francesco Dazzi, John Hoang, Martin Will, Dominik Baack, L. Maraschi, Elina Lindfors, M. A. Kastendieck, R. Rauth, V. Baghmanyan, D. Ninci, Koji Noda, Michael Backes, S. Raab, Sanae Inoue, Giacomo D'Amico, Manuel Meyer, Q. Remy, L. Olivera-Nieto, Dorota Sobczyńska, Elisa Bernardini, M. Filipovic, Riaan Steenkamp, Davit Zargaryan, Hambeleleni Ndiyavala, Stefan Klepser, G. Vasileiadis, G. Lamanna, S. G. Jorstad, Daniel Mazin, Jacek Niemiec, Kirsty Feijen, Alessandro Montanari, Tim Holch, Seiya Nozaki, Anna Barnacka, M. Hörbe, Giacomo Bonnoli, D. Strom, T. Tavernier, Takeshi Oka, Axel Donath, J. Rico, A. W. Chen, J. Dyks, T. Chand, Jim Hinton, F. Niederwanger, Olaf Reimer, Daniel Kerszberg, Manuel Delfino, Krzysztof Katarzynski, Ivica Puljak, S. Sailer, Dmitry Khangulyan, Christian Fruck, Gavin Rowell, D. A. Sanchez, Maria Haupt, Julian Sitarek, Alan P. Marscher, Stefano Truzzi, Pablo Peñil, E. O. Angüner, Catherine Boisson, S. Ventura, Dieter Horns, M. Bryan, V. Barbosa Martins, L. Sun, Rachel Simoni, Gerard Fontaine, Jacco Vink, P. Reichherzer, Jim Davies, G. Hermann, Regis Terrier, Clemens Hoischen, A. A. Zdziarski, G. Ferrara, Francois Brun, G. Emery, M. de Bony de Lavergne, P. Vincent, Kyoshi Nishijima, Alessandra Lamastra, G. Fichet de Clairfontaine, E. de Oña Wilhelmi, P. Munar-Adrover, Yoshiki Ohtani, Carlo Romoli, Jordi Delgado, Wrijupan Bhattacharyya, L. Di Venere, D. Zarić, Zorawar Wadiasingh, F. Di Pierro, Ž. Bošnjak, Hester Schutte, Isak Delberth Davids, Roberta Zanin, Karl Mannheim, M. Strzys, Łukasz Stawarz, R. J. Tuffs, V. Fallah Ramazani, B. Bi, Marc Ribó, Sabrina Casanova, H. Prokoph, A. Carosi, Stefano Covino, D. J. van der Walt, Thomas Murach, Yating Chai, Saša Mićanović, Jae-Young Kim, V. Vitale, Francesco Longo, R. Konno, Alicia Fattorini, Narek Sahakyan, Y. A. Gallant, R. J. García López, Junko Kushida, Jürgen Besenrieder, Dario Hrupec, P. Da Vela, S. Steinmassl, P. G. Prada Moroni, Jonathan Mackey, Rafal Moderski, Stefan Cikota, Hidetoshi Kubo, Armelle Jardin-Blicq, Monica Barnard, J. Otero-Santos, Mischa Breuhaus, J. Becerra González, Yu. W. Wong, V. Joshi, Samuel Zouari, N. Shafi, Natalia Żywucka, E. Prandini, M. A. Lopez, Gianluca Giavitto, Katsuaki Asano, Mitsunari Takahashi, T. Vuillaume, M. Curyło, P. Morris, K. Egberts, Stefano Ansoldi, M. de Naurois, Pawel Gliwny, L. Pavletić, C. Moore, Alessia Spolon, M. Vazquez Acosta, D. Elsaesser, Tomoki Saito, Giovanni Ceribella, Riccardo Paoletti, Celine Armand, Jhilik Majumdar, Stefan Ohm, G. Busetto, Léa Jouvin, Ana Babić, Frank M. Rieger, A. Dmytriiev, Dorit Glawion, Z. R. Weaver, Włodek Kluźniak, S. Chandra, V. Marandon, A. Djannati-Ataï, E. Moulin, Tomasz Bulik, Alessio Berti, M. Seglar-Arroyo, H. Odaka, Christian Stegmann, Stefan Wagner, C. Perennes, Pierre Brun, Yasunobu Uchiyama, A. Fiasson, U. Colin, David A. Green, Kazuma Ishio, A. Arbet Engels, A. De Angelis, Wlodek Bednarek, Nikola Godinovic, F. Ait Benkhali, Vassil Verguilov, Camilla Maggio, L. Mohrmann, Jean-Pierre Ernenwein, M. Spir-Jacob, M. Karjalainen, Vitaly Neustroev, P. deWilt, M. Scalici, Victoria Moreno, A. Priyana Noel, A. López-Oramas, M. Lemoine-Goumard, N. Torres-Albà, Martin Makariev, C. van Rensburg, Oscar Blanch, S. Pita, Alexander Hahn, V. Sahakian, Yusuke Suda, S. Schwemmer, Thomas Lohse, Misao Sasaki, Daniel Morcuende, Johannes Veh, D. Jankowsky, Michael Kreter, D. Berge, Luca Tosti, R. Marx, F. Werner, V. Poireau, Andrea Santangelo, C. Nigro, Andreas Quirrenbach, Jose Luis Contreras, E. Ruiz-Velasco, Thomas Bylund, M. Tluczykont, V. D'Elia, A. S. Seyffert, Jose Miguel Miranda, Massimo Persic, L. Dirson, Efthalia Traianou, Carlo Vigorito, Sargis Gasparyan, Y. Kobayashi, Jacques Muller, Jeffrey A. Hodgson, Marek Jamrozy, Christoph Deil, I. Jung-Richardt, Joachim Hahn, Mohanraj Senniappan, A. Rugliancich, Marina Manganaro, K. Nakashima, Kleopas Shiningayamwe, Alice Donini, Michelle Tsirou, Yuki Iwamura, G. Maneva, L. A. Antonelli, Juan Cortina, Markus Holler, Michal Ostrowski, Wolfgang Rhode, L. Rinchiuso, Felix Jankowsky, Sebastian Panny, M. I. Martínez, Michael Zacharias, Ferdinando Giordano, Felix Aharonian, Lluis Font, J.-P. Lenain, Merja Tornikoski, B. Machado de Oliveira Fraga, M.-H. Grondin, Lenka Tomankova, Markus Böttcher, Alison Mitchell, Chiara Righi, E. Do Souto Espiñeira, Tomislav Terzić, Alexandre Marcowith, P. Temnikov, Helene Sol, Sabrina Einecke, Iryna Lypova, Toshiaki Inada, Rodolfo Carosi, R. D. Parsons, Yvonne Becherini, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Arnaud Mares, Chaitanya Priyadarshi, Satoshi Fukami, Konstancja Satalecka, Stefan Funk, Johan Bregeon, Sidika Merve Colak, Alicja Wierzcholska, R. J. White, F. Leone, Michele Doro, D. Huber, Carolina Casadio, Anne Lähteenmäki, Masahiro Teshima, Domenico Tiziani, D. Malyshev, M. Panter, U. Katz, Heinrich J. Völk, G. Martí-Devesa, C. Levy, M. Renaud, J. A. Barrio, Kai Phillip Schmidt, L. Oakes, N. Giglietto, Simone Mender, Paolo Marchegiani, Ashot Chilingarian, Tjark Miener, James E. M. Watson, David Paneque, J. Bolmont, Manuela Mallamaci, Halim Ashkar, A. Sinha, Fabrizio Tavecchio, Kari Nilsson, B. van Soelen, B. Rudak, R. Adam, D. Miceli, M. Mohamed, Saverio Lombardi, E. Molina, P. T. O'Brien, E. Colombo, Lab Saha, Luca Foffano, C. van Eldik, G. Peron, Garret Cotter, D. Hadasch, D. A. Prokhorov, K. Kosack, Konrad Bernlöhr, B. Peyaud, I. Vovk, G. Pühlhofer, A. Reimer, J. F. Glicenstein, Bruno Khelifi, Serena Loporchio, I. Snidaric, Abelardo Moralejo, Andreas Specovius, E. Moretti, Bernd Schleicher, M. Minev, B. De Lotto, Andrés Baquero, A.M. Taylor, J. Damascene Mbarubucyeye, Christo Venter, Ciro Bigongiari, A. Zech, M. Garczarczyk, R. López-Coto, Q. Piel, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), H.E.S.S., MAGIC, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Department of Atomic Energy (India), Academy of Finland, University of Tokyo, La Caixa, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, Abdalla, H., Adam, R., Aharonian, F., Ait Benkhali, F., Ang??ner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernl??hr, K., Bi, B., B??ttcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., de Bony de Lavergne, M., Bregeon, J., Breuhaus, M., Brun, F., Brun, P., Bryan, M., B??chele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chandra, S., Chen, A., Cotter, G., Cury??o, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Ata??, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., Fichet de Clairfontaine, G., Filipovic, M., Fontaine, G., Funk, S., F????ling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., H??rbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kastendieck, M. A., Katarzy??ski, K., Katz, U., Khangulyan, D., Kh??lifi, B., Klepser, S., Klu??niak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemi??re, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Mart??-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A. M. W., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O???brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., de Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Priyana Noel, A., Prokhorov, D. A., Prokoph, H., P??hlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Sch??ssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, ??., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., V??lk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., ywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Asano, K., Baack, D., Babi??, A., Baquero, A., Barres de Almeida, U., Barrio, J. A., Becerra Gonz??lez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bo??njak, ??., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D???amico, G., D???elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espi??eira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garc??a L??pez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi??, N., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H??tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L??pez, M., L??pez-Coto, R., L??pez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Mart??nez, M., Mazin, D., Mender, S., Mi??anovi??, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavleti??, L., Pe??il, P., Perennes, C., Persic, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Rib??, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., nidari??, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suri??, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzi??, T., Teshima, M., Torres-Alb??, N., Tosti, L., Truzzi, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zari??, D., Jorstad, S. G., Marscher, A. P., Boccardi, B., Casadio, C., Hodgson, J., Kim, J. -Y., Krichbaum, T. P., L??hteenm??ki, A., Tornikoski, M., Traianou, E., Weaver, Z. R., Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University
Subjects: non-thermal, quasars: individual: PKS 1510−089, galaxies: active, relativistic processes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies [radiation mechanisms], Photon, individual: PKS 1510−089 [quasars], Astrophysics::High Energy Astrophysical Phenomena, Flux, radiation mechanisms: non-thermal / quasars: individual: PKS 1510−089 / galaxies: active / relativistic processes, radiation mechanisms: non-thermal, quasars: individual: PKS 1510-089, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, law.invention, law, 0103 physical sciences, Galaxies: Active, Quasars: Individual: Pks 1510-089, Radiation mechanisms: Non-thermal, Relativistic processes, individual: PKS 1510-089 [quasars], MAGIC (telescope), 010303 astronomy & astrophysics, Physics, [PHYS]Physics [physics], 010308 nuclear & particles physics, Astronomy and Astrophysics, Quasar, Light curve, non-thermal [radiation mechanisms], relativistic processes [radiation mechanisms], Extragalactic background light, Space and Planetary Science, active [galaxies], ddc:520, Física nuclear, quasars: individual: PKS 1510��089, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope, Flare
Abstract: The flat spectrum radio quasar (FSRQ) PKS 1510−089 is known for its complex multiwavelength behaviour and it is one of only a few FSRQs detected in very-high-energy (VHE, E > 100 GeV) γ rays. The VHE γ-ray observations with H.E.S.S. and MAGIC in late May and early June 2016 resulted in the detection of an unprecedented flare, which revealed, for the first time, VHE γ-ray intranight variability for this source. While a common variability timescale of 1.5 h has been found, there is a significant deviation near the end of the flare, with a timescale of ∼20 min marking the cessation of the event. The peak flux is nearly two orders of magnitude above the low-level emission. For the first time, a curvature was detected in the VHE γ-ray spectrum of PKS 1510–089, which can be fully explained by the absorption on the part of the extragalactic background light. Optical R-band observations with ATOM revealed a counterpart of the γ-ray flare, even though the detailed flux evolution differs from the VHE γ-ray light curve. Interestingly, a steep flux decrease was observed at the same time as the cessation of the VHE γ-ray flare. In the high-energy (HE, E > 100 MeV) γ-ray band, only a moderate flux increase was observed with Fermi-LAT, while the HE γ-ray spectrum significantly hardens up to a photon index of 1.6. A search for broad-line region (BLR) absorption features in the γ-ray spectrum indicates that the emission region is located outside of the BLR. Radio very-long-baseline interferometry observations reveal a fast-moving knot interacting with a standing jet feature around the time of the flare. As the standing feature is located ∼50 pc from the black hole, the emission region of the flare may have been located at a significant distance from the black hole. If this is indeed a true correlation, the VHE γ rays must have been produced far down in the jet, where turbulent plasma crosses a standing shock., Astronomy & Astrophysics, 648, ISSN:0004-6361, ISSN:1432-0746
Published: 2021

13. Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign

Author: Masanori Nakamura, R. Shang, Abelardo Moralejo, A. Rugliancich, Marina Manganaro, Jun Liu, Monika Moscibrodzka, Andreas Specovius, V. Ramakrishnan, S. O'Brien, Michal Ostrowski, Luis C. Ho, Sera Markoff, D. Depaoli, I. Jung-Richardt, Manel Errando, Chiara Righi, S. Panny, Toshiaki Inada, Alexandra J. Tetarenko, Daniela Dorner, Norbert Wex, Nimesh A. Patel, Olivier Hervet, C. Arcaro, Alasdair E. Gent, Yu Wun Wong, Gaia Vanzo, Pierre Brun, Konstancja Satalecka, Stefan Funk, Lorenzo Bellizzi, Michael Lindqvist, Michele Doro, Felix Jankowsky, P. Kaaret, Nicholas R. MacDonald, Lang Cui, P. Temnikov, S. Patel, Sabrina Einecke, Manuel Artero, E. Moretti, Hope Boyce, M. Gaug, Charles F. Gammie, Iryna Lypova, Gisela N. Ortiz-León, Felix Aharonian, Colin J. Lonsdale, Buell T. Jannuzi, Gavin Rowell, M. Bryan, Yvonne Becherini, Aleksandar Popstefanija, M. Pohl, A. Marcowith, Jean-Pierre Ernenwein, H. Alyson Ford, Wystan Benbow, Karen E. Williamson, Daryl Haggard, Hambeleleni Ndiyavala, Tod R. Lauer, Arnaud Mares, Chaitanya Priyadarshi, Michael Punch, Helge Rottmann, J. Zorn, D. Dominis Prester, Bernd Schleicher, M. Minev, Hector Olivares, Ciriaco Goddi, S. Pita, J. Herrera, Alessia Spolon, Léa Jouvin, Na Wang, G. Martí-Devesa, Tomohiko Oka, Kirsty Feijen, E. Do Souto Espiñeira, Ralph Eatough, Johannes Veh, Stefano Gabici, Tomislav Terzić, D. Glawion, Gilles Fontaine, Bradford Benson, C. B. Rulten, Jenni Jormanainen, Jason SooHoo, Michael Titus, Jose Miguel Delgado, Marcos López-Moya, Freek Roelofs, Wlodek Bednarek, M. Lundy, Richard Anantua, Alessandra Lamastra, P. T. Reynolds, Vassil Verguilov, M. Lemoine-Goumard, G. Fichet de Clairfontaine, L. Di Venere, Michael Kreter, Jose Miguel Miranda, Alan L. Roy, Yating Chai, A. López-Oramas, M. Tluczykont, Jacek Niemiec, R. Konno, Tyler Trent, Olaf Reimer, Heino Falcke, Amanpreet Kaur, M. Panter, Narek Sahakyan, Kasper B. Schmidt, A. Carosi, K. Egberts, L. Maraschi, Stefan Cikota, V. Joshi, Koji Noda, Elisa Bernardini, Ye-Fei Yuan, Garrett K. Keating, Fumie Tazaki, Pawel Gliwny, M. Vazquez Acosta, Nicola Giglietto, M. Capasso, Vincent Piétu, Satoshi Fukami, Roman Gold, Elina Lindfors, Satoki Matsushita, A. Lemiere, F. Eichhorn, U. Katz, Yoshinori Yonekura, N. Shafi, Natalia Żywucka, Michael Kramer, M. Palatiello, Daniel Mazin, Samuel Timothy Spencer, Victoria Moreno, Oliver Porth, Julian Sitarek, Kazi L.J. Rygl, Wen Ping Lo, Geoffrey C. Bower, Ilje Cho, S. Fegan, Samuel Zouari, J. M. Paredes, V. Fallah Ramazani, Thomas Murach, Jim Hinton, R. J. White, F. Leone, S. Loporchio, M. de Naurois, Ed Fomalont, Bart Ripperda, Dominique Broguiere, J. Becerra González, Joseph R. Farah, Q. Feng, Andreas Quirrenbach, Taehyun Jung, C. Trichard, Masahiro Teshima, Domenico Tiziani, D. Malyshev, Richard Plambeck, Lynn D. Matthews, Avery E. Broderick, S. Kumar, T. J. Williamson, M. K. Daniel, Sylvia Zhu, P. J. Meintjes, Tjark Miener, Jodi Christiansen, Roger Brissenden, S. Sailer, Dmitry Khangulyan, David Paneque, Thomas P. Krichbaum, Sergey S. Savchenko, Angelo Ricarte, Riaan Steenkamp, T. Chand, J. Dyks, Francesco Dazzi, V. Baghmanyan, Zorawar Wadiasingh, Kazunori Akiyama, Stefan Ohm, C. Levy, Giovanna Ferrara, Makoto Inoue, Jhilik Majumdar, Nobuyuki Sakai, Dieter Horns, Jorge A. Preciado-López, Cornelia Müller, G. Hermann, Regis Terrier, A. J. Chromey, Dominic W. Pesce, Felix M. Pötzl, Mark Gurwell, Alejandro Cruz-Osorio, Ivan Marti-Vidal, Ben Prather, Tom Armstrong, Jongho Park, Matteo Cerruti, Ziri Younsi, Amy Furniss, Chih-Wei Locutus Huang, Lijing Shao, A. Djannati-Ataï, Shoko Koyama, D. Gottschall, P. Vincent, A. Brill, Kenji Toma, Antonios Nathanail, M. Nievas-Rosillo, M. Seglar-Arroyo, C. Delgado Mendez, Mahito Sasada, G. Busetto, Maciek Wielgus, Marcos Santander, Doosoo Yoon, D. A. Sanchez, Hiroki Okino, Christo Venter, Christiaan D. Brinkerink, James Ryan, S. Mićanović, Raquel Fraga-Encinas, Mark G. Rawlings, G. H. Sembroski, G. Principe, Xiang Liu, Karl Friedrich Schuster, Ronald Hesper, L. Sun, Ciro Bigongiari, Ramesh Narayan, M. Strzys, L. Mohrmann, Daniel R. van Rossum, Y. Ohtani, Wu Jiang, Luciano Rezzolla, Nu. Komin, V. A. Acciari, Katherine L. Bouman, Jürgen Besenrieder, Clemens Hoischen, A. A. Zdziarski, Antonio Tutone, Hung Yi Pu, A. Arbet Engels, J.-P. Lenain, A. De Angelis, Tomoya Hirota, R. J. García López, Carlo Romoli, Werner Hofmann, Tuomas Savolainen, Neil M. Nagar, Minfeng Gu, M. Karjalainen, Vitaly Neustroev, A. N. Otte, John F. C. Wardle, Tomoaki Oyama, Jongsoo Kim, Monica Barnard, J. Otero-Santos, R. D. Parsons, Pierre Christian, A. Priyana Noel, A. S. Seyffert, Shami Chatterjee, E. O. Angüner, David A. Green, Ramesh Karuppusamy, Zhiyuan Li, J. Devin, Dominik Elsaesser, F. Giordano, Santiago Ubach, Michael A. Nowak, Y. Kobayashi, F. Di Pierro, Iniyan Natarajan, A. Zech, M. Garczarczyk, Dmitriy Kostunin, Michael Janssen, Giacomo Bonnoli, Mariafelicia De Laurentis, Kuo Liu, G. Emery, Yutaro Kofuji, Antxon Alberdi, Marco Toliman Lucchini, R. A. Ong, Catherine Boisson, Daniel C. M. Palumbo, Stefan Klepser, Stefano Covino, Motoki Kino, Daniel Kerszberg, C. Armand, Maria Haupt, D. Zarić, K. Pfrang, R. López-Coto, M. Zacharias, Jae-Young Kim, Sheperd S. Doeleman, U. Barres de Almeida, Pratik Majumdar, M. V. Fonseca, Mosè Mariotti, G. Lamanna, Alexander Hahn, Sidika Merve Colak, R. J. Tuffs, B. Bi, Juan-Carlos Algaba, L. Oakes, D. Jankowsky, Y. Kajiwara, R. Marx, Bošnjak, John E. Barrett, Kotaro Niinuma, F. D'Ammando, Qingwen Wu, A. Yusafzai, Christian M. Fromm, Chi-kwan Chan, B. De Lotto, M. Kertzman, Manuela Mallamaci, H. Prokoph, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, E. Kasai, Lea Heckmann, Bong Won Sohn, Francesco Gabriele Saturni, Shiro Ikeda, T. Vuillaume, Laurent Loinard, G. Maurin, M. Füßling, Martin Will, Yi Chen, Gianluca Giavitto, Remo P. J. Tilanus, M. Spir-Jacob, Alessandro Montanari, Thomas Lohse, Tihomir Surić, J. van Scherpenberg, Per Friberg, He Sun, Luca Tosti, Kiyoaki Wajima, E. Ruiz-Velasco, Thomas Bylund, M. Balokovic, Feng Yuan, S. Nozaki, Mischa Breuhaus, Peter Galison, Y. A. Gallant, L. Olivera-Nieto, Dorota Sobczyńska, Maria-Isabel Bernardos, R. Rauth, Izumi Mizuno, Vincent L. Fish, S. G. Jorstad, Tomoki Saito, Giovanni Ceribella, Jacques Muller, J. P. Finley, Stefano Ansoldi, Boris Georgiev, Marcello Giroletti, Arturo I. Gómez-Ruiz, Karl M. Menten, Aristeidis Noutsos, P. deWilt, Junhan Kim, Alejandro Mus Mejías, Q. Remy, Dong-Jin Kim, P. G. Prada Moroni, Robert Wharton, Riccardo Paoletti, R. R. Prado, Zhi-Qiang Shen, S. Paiano, S. Chandra, Andrés Baquero, Anna Barnacka, Lucy Fortson, Wrijupan Bhattacharyya, Marc Ribó, E. de Ona Wilhelmi, Paul T. P. Ho, Yan-Rong Li, Derek Ward-Thompson, M. Scalici, G. Maneva, Constantin Steppa, Dimitrios Psaltis, A.M. Taylor, J. Damascene Mbarubucyeye, Daniel P. Marrone, Karl Mannheim, W. Boland, P. Morris, D. A. Prokhorov, M. Mohamed, Katsuaki Asano, Gernot Maier, Kotaro Moriyama, H. Odaka, M. Büchele, E. Pueschel, Kazuyoshi Nishijima, Christopher J. Duffy, H. M. Schutte, Camilla Maggio, Mark Kettenis, V. D'Elia, Saverio Lombardi, Ramprasad Rao, Ivica Puljak, R. Mirzoyan, V. Sahakian, Guang Yao Zhao, Adrian Biland, F. Werner, Rafal Moderski, Olivier Gentaz, Ullrich Schwanke, James M. Moran, S. Komossa, Yuzhu Cui, A. Jiménez-Rosales, Arash Roshanineshat, S. Ventura, Lindy Blackburn, David J. James, G. Hughes, Hidetoshi Kubo, Mansour Karami, José L. Gómez, P. Reichherzer, Davit Zargaryan, Paul Tiede, Koushik Chatterjee, Chunchong Ni, Roger Deane, Axel Donath, J. Rico, A. W. Chen, A. Fiasson, Jun Yi Koay, T. B. Humensky, Satoko Sawada-Satoh, Isak Delberth Davids, Alan P. Marscher, Alan E. E. Rogers, Rebecca Azulay, Kazuma Ishio, Paul M. Chesler, D. M. Strom, Carlo Vigorito, Marek Jamrozy, G. Pühlhofer, M. de Bony de Lavergne, Roberta Zanin, T. Schweizer, Elisa Prandini, Helene Sol, Rodolfo Carosi, M. Hörbe, T. Tavernier, Mareki Honma, M. Holler, Gordon T. Richards, Armelle Jardin-Blicq, Paolo Marchegiani, Sang-Sung Lee, D. Huber, Ashot Chilingarian, Nikola Godinovic, F. Ait Benkhali, Jason Dexter, Do-Young Byun, Anton Dmytriiev, Massimo Persic, Alicia Fattorini, L. Dirson, Cosimo Nigro, E. Roache, Sargis Gasparyan, S. Schwemmer, Sara Issaoun, Jessica Dempsey, Andrea Santangelo, Włodek Kluźniak, Mel Rose, Huib Jan van Langevelde, D. J. van der Walt, Elisabetta Liuzzo, A. Stamerra, John Hoang, Michelle Tsirou, Wolfgang Rhode, Tomohisa Kawashima, L. A. Antonelli, Carolin Wunderlich, Keiichi Asada, David A. Williams, Joachim Hahn, P. Moriarty, T. M. Crawford, P. Da Vela, L. Rinchiuso, E. Molina, F. Peter Schloerb, Lovro Pavletić, S. Steinmassl, Des Small, Christoph Deil, Stefano Menchiari, Dan Bintley, K. Nakashima, Alice Donini, David H. Hughes, Heinrich J. Völk, Mohanraj Senniappan, K. A. Farrell, M. Renaud, J. A. Barrio, Miriam Lucio Martinez, Rachel Simoni, P. T. O'Brien, E. Colombo, V. Barbosa Martins, M. Orienti, Efthalia Traianou, Lluis Font, B. Machado de Oliveira Fraga, Y. Suda, J. Neilsen, John Conway, Eduardo Ros, Gibwa Musoke, Tarek M. Hassan, J. Bolmont, A. Sinha, Halim Ashkar, M.-H. Grondin, Daniel Nieto, Lab Saha, Fabrizio Tavecchio, Hyunwook Ro, Michael H. Hecht, Markus Böttcher, Antonio Fuentes, Simone Mender, Moritz Hütten, Ue-Li Pen, Yosuke Mizuno, Gopal Narayanan, Lei Huang, H. Abdalla, M. A. Kastendieck, Nicola Marchili, I. Snidaric, S. Sánchez, G. Vasileiadis, Kari Nilsson, Alexander W. Raymond, Greg Lindahl, Gregory Desvignes, Sascha Trippe, Sanae Inoue, Giacomo D'Amico, W. Jin, B. van Soelen, Andrew Chael, Anne Kathrin Baczko, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Walter Alef, Jamie Holder, Stefano Truzzi, Pablo Peñil, M. J. Lang, Francois Brun, Frank M. Rieger, V. Vitale, George N. Wong, Jirong Mao, S. Caroff, J. Kushida, André Young, Ru-Sen Lu, Daniel Morcuende, Jose Luis Contreras, Kazuhiro Hada, Juan Cortina, C. van Eldik, Pablo Torne, Raymond Blundell, Jarred Gershon Green, C. B. Adams, James M. Cordes, Jonathan Weintroub, Q. Piel, A. Berti, James E. M. Watson, G. Peron, Ken Young, Garret Cotter, Dario Hrupec, Jonathan Mackey, K. Ragan, John E. Carlstrom, Michael Backes, Tim Holch, D. Hadasch, Stawarz, F. Niederwanger, Feryal Özel, Lia Medeiros, A. Weinstein, Mitsunari Takahashi, Manuel Delfino, C. Y. Kuo, Aviad Levis, Francesco Longo, K. Kosack, Konrad Bernlöhr, Jacco Vink, C. Moore, Michael Bremer, Jim Davies, Jadyn Anczarski, Patrick M. Koch, Sabrina Casanova, Ming-Tang Chen, B. Peyaud, Christian Stegmann, Stefan Wagner, C. Perennes, Yasunobu Uchiyama, David Kieda, Chet Ruszczyk, Hiroshi Nagai, M. Curyło, Andrei Lobanov, Ana Babić, E. Moulin, Tomasz Bulik, Britton Jeter, I. Vovk, Martin Makariev, C. van Rensburg, Oscar Blanch, Rocco Lico, Silke Britzen, Misao Sasaki, A. Reimer, V. Poireau, R. Adam, David Ball, Mark Reynolds, D. Miceli, John L. Quinn, Roberto Garcia, J. F. Glicenstein, D. Ribeiro, A. Wierzcholska, Geoffrey B. Crew, Bruno Khelifi, David Sánchez-Arguelles, Ilse van Bemmel, Michael D. Johnson, J. Anton Zensus, Dominik Baack, Manuel Meyer, E. V. Kravchenko, I. Jiménez, Thomas Bronzwaer, Reshmi Mukherjee, D. Berge, C. Giuri, Kleopas Shiningayamwe, Shan Shan Zhao, Yuki Iwamura, A. D. Falcone, Lenka Tomankova, Carsten Kramer, Jan Wagner, Christian Fruck, B. Rudak, Jordy Davelaar, V. Marandon, K. Katarzyński, Roberto Neri, The EHT MWL Science Working Group, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Instituto de RadioAstronomía Milimétrica (IRAM), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Groupe de Physique des Solides (GPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL), Event Horizon Telescope, Fermi-LAT, H.E.S.S., MAGIC, VERITAS, EAVN, High Energy Astrophys. & Astropart. Phys (API, FNWI), API Other Research (FNWI), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Algaba, Jc, Anczarski, J, Asada, K, Balokovic, M, Chandra, S, Cui, Yz, Falcone, Ad, Giroletti, M, Goddi, C, Hada, K, Haggard, D, Jorstad, S, Kaur, A, Kawashima, T, Keating, G, Kim, Jy, Kino, M, Komossa, S, Kravchenko, Ev, Krichbaum, Tp, Lee, S, Lu, R, Lucchini, M, Markoff, S, Neilsen, J, Nowak, Ma, Park, J, Principe, G, Ramakrishnan, V, Reynolds, Mt, Sasada, M, Savchenko, S, Williamson, Ke, Longo, F, Et, Al., University of Michigan, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Algaba, J. C., Anczarski, J., Asada, K., Balokovic, M., Chandra, S., Cui, Y. -Z., Falcone, A. D., Giroletti, M., Goddi, C., Hada, K., Haggard, D., Jorstad, S., Kaur, A., Kawashima, T., Keating, G., Kim, J. -Y., Kino, M., Komossa, S., Kravchenko, E. V., Krichbaum, T. P., Lee, S. -S., Lu, R. -S., Lucchini, M., Markoff, S., Neilsen, J., Nowak, M. A., Park, J., Principe, G., Ramakrishnan, V., Reynolds, M. T., Sasada, M., Savchenko, S. S., Williamson, K. E., Akiyama, K., Alberdi, A., Alef, W., Anantua, R., Azulay, R., Baczko, A. -K., Ball, D., Barrett, J., Bintley, D., Benson, B. A., Blackburn, L., Blundell, R., Boland, W., Bouman, K. L., Bower, G. C., Boyce, H., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Byun, D. -Y., Carlstrom, J. E., Chael, A., Chan, C. -K., Chatterjee, S., Chatterjee, K., Chen, M. -T., Chen, Y., Chesler, P. M., Cho, I., Christian, P., Conway, J. E., Cordes, J. M., Crawford, T. M., Crew, G. B., Cruz-Osorio, A., Davelaar, J., De Laurentis, M., Deane, R., Dempsey, J., Desvignes, G., Dexter, J., Doeleman, S. S., Eatough, R. P., Falcke, H., Farah, J., Fish, V. L., Fomalont, E., Ford, H. A., Fraga-Encinas, R., Friberg, P., Fromm, C. M., Fuentes, A., Galison, P., Gammie, C. F., Garcia, R., Gentaz, O., Georgiev, B., Gold, R., Gomez, J. L., Gomez-Ruiz, A. I., Gu, M., Gurwell, M., Hecht, M. H., Hesper, R., Ho, L. C., Ho, P., Honma, M., Huang, C. -W. L., Huang, L., Hughes, D. H., Ikeda, S., Inoue, M., Issaoun, S., James, D. J., Jannuzi, B. T., Janssen, M., Jeter, B., Jiang, W., Jimenez-Rosales, A., Johnson, M. D., Jung, T., Karami, M., Karuppusamy, R., Kettenis, M., Kim, D. -J., Kim, J., Koay, J. Y., Kofuji, Y., Koch, P. M., Koyama, S., Kramer, M., Kramer, C., Kuo, C. -Y., Lauer, T. R., Levis, A., Li, Y. -R., Li, Z., Lindqvist, M., Lico, R., Lindahl, G., Liu, J., Liu, K., Liuzzo, E., Lo, W. -P., Lobanov, A. P., Loinard, L., Lonsdale, C., Macdonald, N. R., Mao, J., Marchili, N., Marrone, D. P., Marscher, A. P., Marti-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Mizuno, I., Mizuno, Y., Moran, J. M., Moriyama, K., Moscibrodzka, M., Muller, C., Musoke, G., Mejias, A. M., Nagai, H., Nagar, N. M., Nakamura, M., Narayan, R., Narayanan, G., Natarajan, I., Nathanail, A., Neri, R., Ni, C., Noutsos, A., Okino, H., Olivares, H., Ortiz-Leon, G. N., Oyama, T., Ozel, F., Palumbo, D. C. M., Patel, N., Pen, U. -L., Pesce, D. W., Pietu, V., Plambeck, R., Popstefanija, A., Porth, O., Potzl, F. M., Prather, B., Preciado-Lopez, J. A., Psaltis, D., Pu, H. -Y., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ricarte, A., Ripperda, B., Roelofs, F., Rogers, A., Ros, E., Rose, M., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruszczyk, C., Rygl, K. L. J., Sanchez, S., Sanchez-Arguelles, D., Savolainen, T., Schloerb, F. P., Schuster, K. -F., Shao, L., Shen, Z., Small, D., Sohn, B. W., Soohoo, J., Sun, H., Tazaki, F., Tetarenko, A. J., Tiede, P., Tilanus, R. P. J., Titus, M., Toma, K., Torne, P., Trent, T., Traianou, E., Trippe, S., Van Bemmel, I., Van Langevelde, H. J., Van Rossum, D. R., Wagner, J., Ward-Thompson, D., Wardle, J., Weintroub, J., Wex, N., Wharton, R., Wielgus, M., Wong, G. N., Wu, Q., Yoon, D., Young, A., Young, K., Younsi, Z., Yuan, F., Yuan, Y. -F., Zensus, J. A., Zhao, G. -Y., Zhao, S. -S., D'Ammando, F., Orienti, M., Abdalla, H., Adam, R., Aharonian, F., Benkhali, F. A., Anguner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlohr, K., Bi, B., Bottcher, M., Boisson, C., Bolmont, J., De Bony De Lavergne, M., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Buchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chen, A., Cotter, G., Curylo, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., De Clairfontaine, G. F., Fontaine, G., Funk, S., Fussling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzynski, K., Katz, U., Khangulyan, D., Khelifi, B., Klepser, S., Kluzniak, W., Komin, N., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., De Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., De Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. P., Prokhorov, D. A., Prokoph, H., Puhlhofer, G., Punch, M., Quirrenbach, A., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., Van Der Walt, D. J., Van Eldik, C., Van Rensburg, C., Van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Volk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Y. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., Zywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. A., Artero, M., Asano, K., Baack, D., Babic, A., Baquero, A., De Almeida, U. B., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jimenez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez-Coto, R., Lopez-Moya, M., Lopez-Oramas, A., Loporchio, S., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Menchiari, S., Mender, S., Micanovic, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletic, L., Penil, P., Perennes, C., Persic, M., Moroni, P. G. P., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zaric, D., Adams, C. B., Benbow, W., Brill, A., Capasso, M., Christiansen, J. L., Chromey, A. J., Daniel, M. K., Errando, M., Farrell, K. A., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Gent, A., Giuri, C., Hassan, T., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Jin, W., Kaaret, P., Kertzman, M., Kieda, D., Kumar, S., Lang, M. J., Lundy, M., Maier, G., Moriarty, P., Mukherjee, R., Nieto, D., Nievas-Rosillo, M., O'Brien, S., Ong, R. A., Otte, A. N., Patel, S., Pfrang, K., Pohl, M., Prado, R. R., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Ribeiro, D., Richards, G. T., Roache, E., Rulten, C., Ryan, J. L., Santander, M., Sembroski, G. H., Shang, R., Weinstein, A., Williams, D. A., Williamson, T. J., Hirota, T., Cui, L., Niinuma, K., Ro, H., Sakai, N., Sawada-Satoh, S., Wajima, K., Wang, N., Liu, X., Yonekura, Y., German Research Foundation, Istituto Nazionale di Fisica Nucleare, Swiss National Science Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Department of Atomic Energy (India), University of Tokyo, Japan Society for the Promotion of Science, Ministry of Education and Scientific Research (Romania), Academy of Finland, La Caixa, Croatian Science Foundation, Generalitat de Catalunya, Polish National Agency for Academic Exchange, University of Rijeka, Department of Energy (US), Smithsonian Institution, Astronomy, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: Accretion, 010504 meteorology & atmospheric sciences, Astronomy, Flux, Astrophysics, 7. Clean energy, 01 natural sciences, Active galactic nuclei, Radio cores, Low-luminosity active galactic nuclei, High energy astrophysics, Astrophysical black holes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, Radio core, Accretion (meteorology), 520 Astronomie und zugeordnete Wissenschaften, Low-luminosity, active galactic nuclei, Astrophysical black hole, astro-ph.CO, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Active galactic nucleus, High-energy astronomy, astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, F500, Astrophysics::Cosmology and Extragalactic Astrophysics, High energy astrophysic, 0103 physical sciences, Very-long-baseline interferometry, ddc:530, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Event Horizon Telescope, Supermassive black hole, Astronomy and Astrophysics, 530 Physik, Galaxy, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), ddc:520, HESS - Abteilung Hinton, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Full list of authors: EHT MWL Science Working Group; Algaba, J. C.; Anczarski, J.; Asada, K.; Baloković, M.; Chandra, S.; Cui, Y. -Z.; Falcone, A. D.; Giroletti, M.; Goddi, C.; Hada, K.; Haggard, D.; Jorstad, S.; Kaur, A.; Kawashima, T.; Keating, G.; Kim, J. -Y.; Kino, M.; Komossa, S.; Kravchenko, E. V.; Krichbaum, T. P.; Lee, S. -S.; Lu, R. -S.; Lucchini, M.; Markoff, S.; Neilsen, J.; Nowak, M. A.; Park, J.; Principe, G.; Ramakrishnan, V.; Reynolds, M. T.; Sasada, M.; Savchenko, S. S.; Williamson, K. E.; Event Horizon Telescope Collaboration; Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Anantua, Richard; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Barrett, John; Bintley, Dan; Benson, Bradford A.; Blackburn, Lindy; Blundell, Raymond; Boland, Wilfred; Bouman, Katherine L.; Bower, Geoffrey C.; Boyce, Hope; Bremer, Michael; Brinkerink, Christiaan D.; Brissenden, Roger; Britzen, Silke; Broderick, Avery E.; Broguiere, Dominique; Bronzwaer, Thomas; Byun, Do-Young; Carlstrom, John E.; Chael, Andrew; Chan, Chi-Kwan; Chatterjee, Shami; Chatterjee, Koushik; Chen, Ming-Tang; Chen, Yongjun; Chesler, Paul M.; Cho, Ilje; Christian, Pierre; Conway, John E.; Cordes, James M.; Crawford, Thomas M.; Crew, Geoffrey B.; Cruz-Osorio, Alejandro; Davelaar, Jordy; de Laurentis, Mariafelicia; Deane, Roger; Dempsey, Jessica; Desvignes, Gregory; Dexter, Jason; Doeleman, Sheperd S.; Eatough, Ralph P.; Falcke, Heino; Farah, Joseph; Fish, Vincent L.; Fomalont, Ed; Ford, H. Alyson; Fraga-Encinas, Raquel; Friberg, Per; Fromm, Christian M.; Fuentes, Antonio; Galison, Peter; Gammie, Charles F.; García, Roberto; Gentaz, Olivier; Georgiev, Boris; Gold, Roman; Gómez, José L.; Gómez-Ruiz, Arturo I.; Gu, Minfeng; Gurwell, Mark; Hecht, Michael H.; Hesper, Ronald; Ho, Luis C.; Ho, Paul; Honma, Mareki; Huang, Chih-Wei L.; Huang, Lei; Hughes, David H.; Ikeda, Shiro; Inoue, Makoto; Issaoun, Sara; James, David J.; Jannuzi, Buell T.; Janssen, Michael; Jeter, Britton; Jiang, Wu; Jiménez-Rosales, Alejandra; Johnson, Michael D.; Jung, Taehyun; Karami, Mansour; Karuppusamy, Ramesh; Kettenis, Mark; Kim, Dong-Jin; Kim, Jongsoo; Kim, Junhan; Koay, Jun Yi; Kofuji, Yutaro; Koch, Patrick M.; Koyama, Shoko; Kramer, Michael; Kramer, Carsten; Kuo, Cheng-Yu; Lauer, Tod R.; Levis, Aviad; Li, Yan-Rong; Li, Zhiyuan; Lindqvist, Michael; Lico, Rocco; Lindahl, Greg; Liu, Jun; Liu, Kuo; Liuzzo, Elisabetta; Lo, Wen-Ping; Lobanov, Andrei P.; Loinard, Laurent; Lonsdale, Colin; MacDonald, Nicholas R.; Mao, Jirong; Marchili, Nicola; Marrone, Daniel P.; Marscher, Alan P.; Martí-Vidal, Iván; Matsushita, Satoki; Matthews, Lynn D.; Medeiros, Lia; Menten, Karl M.; Mizuno, Izumi; Mizuno, Yosuke; Moran, James M.; Moriyama, Kotaro; Moscibrodzka, Monika; Müller, Cornelia; Musoke, Gibwa; Mejías, Alejandro Mus; Nagai, Hiroshi; Nagar, Neil M.; Nakamura, Masanori; Narayan, Ramesh; Narayanan, Gopal; Natarajan, Iniyan; Nathanail, Antonios; Neri, Roberto; Ni, Chunchong; Noutsos, Aristeidis; Okino, Hiroki; Olivares, Héctor; Ortiz-León, Gisela N.; Oyama, Tomoaki; Özel, Feryal; Palumbo, Daniel C. M.; Patel, Nimesh; Pen, Ue-Li; Pesce, Dominic W.; Piétu, Vincent; Plambeck, Richard; Popstefanija, Aleksandar; Porth, Oliver; Pötzl, Felix M.; Prather, Ben; Preciado-López, Jorge A.; Psaltis, Dimitrios; Pu, Hung-Yi; Rao, Ramprasad; Rawlings, Mark G.; Raymond, Alexander W.; Rezzolla, Luciano; Ricarte, Angelo; Ripperda, Bart; Roelofs, Freek; Rogers, Alan; Ros, Eduardo; Rose, Mel; Roshanineshat, Arash; Rottmann, Helge; Roy, Alan L.; Ruszczyk, Chet; Rygl, Kazi L. J.; Sánchez, Salvador; Sánchez-Arguelles, David; Savolainen, Tuomas; Schloerb, F. Peter; Schuster, Karl-Friedrich; Shao, Lijing; Shen, Zhiqiang; Small, Des; Sohn, Bong Won; Soohoo, Jason; Sun, He; Tazaki, Fumie; Tetarenko, Alexandra J.; Tiede, Paul; Tilanus, Remo P. J.; Titus, Michael; Toma, Kenji; Torne, Pablo; Trent, Tyler; Traianou, Efthalia; Trippe, Sascha; van Bemmel, Ilse; van Langevelde, Huib Jan; van Rossum, Daniel R.; Wagner, Jan; Ward-Thompson, Derek; Wardle, John; Weintroub, Jonathan; Wex, Norbert; Wharton, Robert; Wielgus, Maciek; Wong, George N.; Wu, Qingwen; Yoon, Doosoo; Young, André; Young, Ken; Younsi, Ziri; Yuan, Feng; Yuan, Ye-Fei; Zensus, J. Anton; Zhao, Guang-Yao; Zhao, Shan-Shan; Fermi Large Area Telescope Collaboration; Principe, G.; Giroletti, M.; D'Ammando, F.; Orienti, M.; H. E. S. S. Collaboration; Abdalla, H.; Adam, R.; Aharonian, F.; Benkhali, F. Ait; Angüner, E. O.; Arcaro, C.; Armand, C.; Armstrong, T.; Ashkar, H.; Backes, M.; Baghmanyan, V.; Barbosa Martins, V.; Barnacka, A.; Barnard, M.; Becherini, Y.; Berge, D.; Bernlöhr, K.; Bi, B.; Böttcher, M.; Boisson, C.; Bolmont, J.; de Lavergne, M. De Bony; Breuhaus, M.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Bylund, T.; Caroff, S.; Carosi, A.; Casanova, S.; Chand, T.; Chen, A.; Cotter, G.; Curyło, M.; Damascene Mbarubucyeye, J.; Davids, I. D.; Davies, J.; Deil, C.; Devin, J.; Dewilt, P.; Dirson, L.; Djannati-Ataï, A.; Dmytriiev, A.; Donath, A.; Doroshenko, V.; Duffy, C.; Dyks, J.; Egberts, K.; Eichhorn, F.; Einecke, S.; Emery, G.; Ernenwein, J. -P.; Feijen, K.; Fegan, S.; Fiasson, A.; de Clairfontaine, G. Fichet; Fontaine, G.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Giavitto, G.; Giunti, L.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M. -H.; Hahn, J.; Haupt, M.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Hörbe, M.; Horns, D.; Huber, D.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jardin-Blicq, A.; Joshi, V.; Jung-Richardt, I.; Kasai, E.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Khangulyan, D.; Khélifi, B.; Klepser, S.; Kluźniak, W.; Komin, Nu.; Konno, R.; Kosack, K.; Kostunin, D.; Kreter, M.; Lamanna, G.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J. -P.; Levy, C.; Lohse, T.; Lypova, I.; Mackey, J.; Majumdar, J.; Malyshev, D.; Malyshev, D.; Marandon, V.; Marchegiani, P.; Marcowith, A.; Mares, A.; Martí-Devesa, G.; Marx, R.; Maurin, G.; Meintjes, P. J.; Meyer, M.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Montanari, A.; Moore, C.; Morris, P.; Moulin, E.; Muller, J.; Murach, T.; Nakashima, K.; Nayerhoda, A.; de Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Olivera-Nieto, L.; de Ona Wilhelmi, E.; Ostrowski, M.; Panter, M.; Panny, S.; Parsons, R. D.; Peron, G.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Noel, A. Priyana; Prokhorov, D. A.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Rauth, R.; Reichherzer, P.; Reimer, A.; Reimer, O.; Remy, Q.; Renaud, M.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Ruiz-Velasco, E.; Sahakian, V.; Sailer, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Scalici, M.; Schutte, H. M.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Senniappan, M.; Seyffert, A. S.; Shafi, N.; Shiningayamwe, K.; Simoni, R.; Sinha, A.; Sol, H.; Specovius, A.; Spencer, S.; Spir-Jacob, M.; Stawarz, Ł.; Sun, L.; Steenkamp, R.; Stegmann, C.; Steinmassl, S.; Steppa, C.; Takahashi, T.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tiziani, D.; Tluczykont, M.; Tomankova, L.; Trichard, C.; Tsirou, M.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Vincent, P.; Vink, J.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Watson, J.; Werner, F.; White, R.; Wierzcholska, A.; Wong, Yu Wun; Yusafzai, A.; Zacharias, M.; Zanin, R.; Zargaryan, D.; Zdziarski, A. A.; Zech, A.; Zhu, S. J.; Zorn, J.; Zouari, S.; Żywucka, N.; MAGIC Collaboration; Acciari, V. A.; Ansoldi, S.; Antonelli, L. A.; Engels, A. Arbet; Artero, M.; Asano, K.; Baack, D.; Babić, A.; Baquero, A.; de Almeida, U. Barres; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bellizzi, L.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Biland, A.; Blanch, O.; Bonnoli, G.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colak, S. M.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; di Pierro, F.; di Venere, L.; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Dorner, D.; Doro, M.; Elsaesser, D.; Ramazani, V. Fallah; Fattorini, A.; Ferrara, G.; Fonseca, M. V.; Font, L.; Fruck, C.; Fukami, S.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Inoue, S.; Ishio, K.; Iwamura, Y.; Jiménez, I.; Jormanainen, J.; Jouvin, L.; Kajiwara, Y.; Karjalainen, M.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Neustroev, V.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Perennes, C.; Persic, M.; Moroni, P. G. Prada; Prandini, E.; Priyadarshi, C.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Saha, L.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schleicher, B.; Schmidt, K.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Zarić, D.; VERITAS Collaboration; Adams, C. B.; Benbow, W.; Brill, A.; Capasso, M.; Christiansen, J. L.; Chromey, A. J.; Daniel, M. K.; Errando, M.; Farrell, K. A.; Feng, Q.; Finley, J. P.; Fortson, L.; Furniss, A.; Gent, A.; Giuri, C.; Hassan, T.; Hervet, O.; Holder, J.; Hughes, G.; Humensky, T. B.; Jin, W.; Kaaret, P.; Kertzman, M.; Kieda, D.; Kumar, S.; Lang, M. J.; Lundy, M.; Maier, G.; Moriarty, P.; Mukherjee, R.; Nieto, D.; Nievas-Rosillo, M.; O'Brien, S.; Ong, R. A.; Otte, A. N.; Patel, S.; Pfrang, K.; Pohl, M.; Prado, R. R.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Ribeiro, D.; Richards, G. T.; Roache, E.; Rulten, C.; Ryan, J. L.; Santander, M.; Sembroski, G. H.; Shang, R.; Weinstein, A.; Williams, D. A.; Williamson, T. J.; Eavn Collaboration; Hirota, Tomoya; Cui, Lang; Niinuma, Kotaro; Ro, Hyunwook; Sakai, Nobuyuki; Sawada-Satoh, Satoko; Wajima, Kiyoaki; Wang, Na; Liu, Xiang; Yonekura, Yoshinori, In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded., The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovacion (MICINN) (FPA2017-87859-P, FPA2017-85668-P, FPA2017- 82729-C6-5-R, FPA2017-90566-REDC, PID2019-104114RBC31, PID2019-104114RB-C32, PID2019-105510GB-C31,PID 2019-107847RB-C41, PID2019-107847RB-C42, PID2019- 107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-268/16.12.2019 and the Academy of Finland grant No. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and CEX2019- 000920-S, and “Maria de Maeztu” CEX2019-000918-M, the Unidad de Excelencia “Maria de Maeztu” MDM-2015-0509- 18-2 and the “la Caixa” Foundation (fellowship LCF/BQ/ PI18/11630012) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq, and FAPERJ. This research is supported by grants from the U.S. Department of Energy Office of Science, the U.S. National Science Foundation and the Smithsonian Institution, by NSERC in Canada, and by the Helmholtz Association in Germany. This research used resources provided by the Open Science Grid, which is supported by the National Science Foundation and the U.S. Department of Energy’s Office of Science, and resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under Contract No. DE-AC02-05CH11231. We acknowledge the excellent work of the technical support staff at the Fred Lawrence Whipple Observatory and at the collaborating institutions in the construction and operation of the instrument.
Published: 2021

14. Very high energy γ-ray emission from two blazars of unknown redshift and upper limits on their distance

Author: Johan Bregeon, J. Devin, D. Gottschall, Zorawar Wadiasingh, Tadayuki Takahashi, R. J. White, Łukasz Stawarz, V. Barbosa Martins, H.M. Schutte, Maria Haupt, Thomas Lohse, Victor Doroshenko, Domenico Tiziani, M. Lemoine-Goumard, C. Arcaro, Michal Ostrowski, J.-P. Lenain, M. Panter, U. Katz, Michael Kreter, Jim Hinton, A. Lemiere, F. Eichhorn, M. de Naurois, R. Adam, Stefan Ohm, James Davies, Stefan Funk, Alicja Wierzcholska, Michael Punch, S. Sailer, Dmitry Khangulyan, D. A. Sanchez, H. Abdalla, M. Zacharias, M. A. Kastendieck, Stefano Gabici, T. Vuillaume, Rafal Moderski, R. J. Tuffs, N. Shafi, Natalia Żywucka, A. Fiasson, Samuel Timothy Spencer, M. Spir-Jacob, M. Seglar-Arroyo, Alexandre Marcowith, A. Santangelo, V. Baghmanyan, Nu. Komin, T. Chand, Jhilik Majumdar, J. Dyks, V. Joshi, P. deWilt, F. Ait Benkhali, L. Oakes, J. Bolmont, Mischa Breuhaus, Heike Prokoph, E. O. Angüner, G. Lamanna, Anton Dmytriiev, Davit Zargaryan, Ruizhi Yang, Q. Piel, Dmitriy Kostunin, Krzysztof Katarzynski, Catherine Boisson, Axel Donath, A. W. Chen, S. Caroff, V. Sahakian, F. Werner, G. Pühlhofer, Arnaud Mares, D. Jankowsky, R. Marx, M. Füßling, S. Schwemmer, Q. Remy, R. Rauth, Dieter Horns, G. Maurin, Y. A. Gallant, Marek Jamrozy, Clemens Hoischen, A. A. Zdziarski, A.S. Seyffert, R. Konno, M. Barnard, S. Nakashima, Anna Barnacka, Gavin Rowell, M. Mohamed, Riaan Steenkamp, M. Bryan, Helene Sol, A. Carosi, M. Hörbe, Sylvia Zhu, P. J. Meintjes, Michelle Tsirou, Christian Stegmann, Stefan Wagner, E. de Oña Wilhelmi, D. Malyshev, S. Raab, Yasunobu Uchiyama, J. Zorn, L. Rinchiuso, Isak Delberth Davids, Kirsty Feijen, Frank M. Rieger, Pierre Brun, R. D. Parsons, T. Tavernier, Jean-Pierre Ernenwein, I. Jung-Richardt, Jason John Watson, Roberta Zanin, L. Mohrmann, V. Poireau, Gianluca Giavitto, C. van Rensburg, S. Pita, Johannes Veh, K. Bernlöhr, H. Yoneda, Paolo Marchegiani, M. Tluczykont, D. J. van der Walt, A. Djannati-Ataï, Francois Brun, P. Vincent, Markus Holler, Misao Sasaki, Felix Jankowsky, Jacek Niemiec, V. Marandon, C. Trichard, H. Odaka, Felix Aharonian, Olaf Reimer, S. Bonnefoy, Constantin Steppa, Garret Cotter, Celine Armand, Michael Backes, E. Ruiz-Velasco, Thomas Bylund, D. Huber, M.-H. Grondin, Tim Holch, E. Leser, Thomas Murach, Joachim Hahn, J. Muller, G. Hermann, Regis Terrier, D. A. Prokhorov, K. Kosack, C. Levy, Ullrich Schwanke, Naomi Tsuji, Carlo Romoli, Angel Noel, Jonathan Mackey, D. Berge, Gerard Fontaine, B. Peyaud, Iryna Lypova, S. Chandra, L. Giunti, M. Katsuragawa, Yvonne Becherini, C. Moore, Dorit Glawion, K. Egberts, E. Moulin, A. Reimer, Tomasz Bulik, Halim Ashkar, Andreas Quirrenbach, M. Böttcher, Paul J. Morris, Kleopas Shiningayamwe, P. T. O'Brien, Lenka Tomankova, C. van Eldik, L. Dirson, J. F. Glicenstein, Tom Armstrong, Matteo Cerruti, H. Ndiyavala, B. van Soelen, B. Rudak, F. Schüssler, Werner Hofmann, M. Büchele, S. J. Fegan, F. Niederwanger, Bruno Khelifi, Jacco Vink, Sabrina Casanova, M. Curyło, Rachel Simoni, Masanori Arakawa, M. Scalici, G. Martí-Devesa, H. Iwasaki, G. Vasileiadis, Włodek Kluźniak, Christoph Deil, Mohanraj Senniappan, G. Emery, S. Saito, Armelle Jardin-Blicq, K. Nakashima, Heinrich J. Völk, M. Renaud, A. Sinha, Christo Venter, A. Zech, A.M. Taylor, Andreas Specovius, Stefan Klepser, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), H.E.S.S., German Research Foundation, Alexander von Humboldt Foundation, Centre National de la Recherche Scientifique (France), Japan Society for the Promotion of Science, Science and Technology Facilities Council (UK), Fundación 'la Caixa', National Aeronautics and Space Administration (US), H.E.S.S. Collaboration, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 30366755 - Chand, Tej B., 31125417 - Chandra, Sunil, 33379009 - Kreter, Michael, 26403366 - Ndiyavala, Hambeleleni, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 10060499 - Van der Walt, Diederick Johannes, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, and 34208968 - Zywucka-Hejzner, Natalia
Subjects: individual [BL Lacertae objects], Swift Gamma-Ray Burst Mission, VHE [gamma ray], satellite, Resolved and unresolved sources as a function of wavelength, Astrophysics, 01 natural sciences, GLAST, blazar, high-redshift [Galaxies], galaxies: high-redshift, 5/3, HESS, 0103 physical sciences, Atom, High Energy Stereoscopic System, Spectroscopy, Blazar, 010303 astronomy & astrophysics, BL Lacertae objects: individual, Astroparticle physics, Physics, general [Gamma-rays], energy: high, 010308 nuclear & particles physics, Astronomy and Astrophysics, gamma-rays: general, redshift, Redshift, gamma ray: VHE, 13. Climate action, Space and Planetary Science, ddc:520, high [energy], HESS - Abteilung Hinton, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract: H.E.S.S. Collaboration: et al., We report on the detection of very high energy (VHE; E > 100 GeV) γ-ray emission from the BL Lac objects KUV 00311−1938 and PKS 1440−389 with the High Energy Stereoscopic System (H.E.S.S.). H.E.S.S. observations were accompanied or preceded by multiwavelength observations with Fermi/LAT, XRT and UVOT onboard the Swift satellite, and ATOM. Based on an extrapolation of the Fermi/LAT spectrum towards the VHE γ-ray regime, we deduce a 95 per cent confidence level upper limit on the unknown redshift of KUV 00311−1938 of z < 0.98 and of PKS 1440−389 of z < 0.53. When combined with previous spectroscopy results, the redshift of KUV 00311−1938 is constrained to 0.51 ≤ z < 0.98 and of PKS 1440−389 to 0.14 ⪅ z < 0.53., The support of the Namibian authorities and of the University of Namibia in facilitating the construction and operation of H.E.S.S. is gratefully acknowledged, as is the support by the German Ministry for Education and Research (BMBF), the Max Planck Society, the German Research Foundation (DFG), the Helmholtz Association, the Alexander von Humboldt Foundation, the French Ministry of Higher Education, Research and Innovation, the Centre National de la Recherche Scientifique (CNRS/IN2P3 and CNRS/INSU), the Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA), the U.K. Science and Technology Facilities Council (STFC), the Knut and Alice Wallenberg Foundation, the National Science Centre, Poland grant no. 2016/22/M/ST9/00382, the South African Department of Science and Technology and National Research Foundation, the University of Namibia, the National Commission on Research, Science and Technology of Namibia (NCRST), the Austrian Federal Ministry of Education, Science and Research and the Austrian Science Fund (FWF), the Australian Research Council (ARC), the Japan Society for the Promotion of Science, and the University of Amsterdam. We appreciate the excellent work of the technical support staff in Berlin, Zeuthen, Heidelberg, Palaiseau, Paris, Saclay, Tubingen, and in Namibia in the construction and operation of the equipment. This work benefited from services provided by the H.E.S.S. Virtual Organisation, supported by the national resource providers of the EGI Federation. The H.E.S.S. and Fermi/LAT analysis computations were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) at Lunarc. Tomas Bylund and Yvonne Becherini wish to acknowledge the support of the Data Intensive Sciences and Applications (DISA) centre at Linnaeus University. Matteo Cerruti has received financial support through the Postdoctoral Junior Leader Fellowship Programme from “la Caixa” Foundation (LCF/BQ/PI18/11630012). This research made use of the NASA/IPAC Extragalactic Database (NED) and of the SIMBAD Astronomical Database, of data products from the Wide-field Infrared Survey Explorer, which is a joint project of the University of California, Los Angeles, and the Jet Propulsion Laboratory/California Institute of Technology, funded by the National Aeronautics and Space Administration. We acknowledge the use of public data from the Swift data archive. This research made use of Gammapy, a community- developed core Python package for gamma-ray astronomy (Deil et al. 2017). This research has made use of data and software provided by the Fermi Science Support Center, managed by the HEASARC at the Goddard Space Flight Center. Part of this work is based on archival data, software or online services provided by the Space Science Data Center - ASI. This research has made use of the VizieR catalogue access tool, CDS, Strasbourg, France (doi:10.26093/cds/vizier). The original description of the VizieR service was published in A&AS 143, 23. This research has made use of the NASA/IPAC Infrared Science Archive, which is funded by the National Aeronautics and Space Administration and operated by the California Institute of Technology.
Published: 2020

15. Detection of very-high-energy γ -ray emission from the colliding wind binary η Car with H.E.S.S

Author: E. O. Angüner, Ramin Marx, M. Panter, U. Katz, G. Heinzelmann, Iryna Lypova, S. Nakashima, Yvonne Becherini, G. Martí-Devesa, Stefan Klepser, H. Yoneda, A. Fiasson, L. Giunti, P. deWilt, J. King, R. Adam, I. Jung-Richardt, James Davies, F. Eichhorn, Michael Punch, Maria Haupt, R. J. Tuffs, Michal Ostrowski, J.-P. Lenain, Stefan Ohm, Łukasz Stawarz, J. F. Glicenstein, Frank M. Rieger, Markus Holler, Michelle Tsirou, C. Levy, S. Pita, S. Colafrancesco, L. Rinchiuso, Q. Remy, Felix Jankowsky, J. Zorn, M.-H. Grondin, Mischa Breuhaus, C. Arcaro, Stefano Gabici, F. Niederwanger, Jacco Vink, Sabrina Casanova, Halim Ashkar, M. Curyło, Stefan Funk, Alicja Wierzcholska, Gavin Rowell, M. Bryan, Felix Aharonian, N. Shafi, R. D. Parsons, H. Ndiyavala, B. van Soelen, B. Rudak, Dmitriy Kostunin, K. Nakashima, Nu. Komin, Natalia Żywucka, M. de Naurois, T. Chand, Jhilik Majumdar, L. Oakes, A. Lemière, Heinrich J. Völk, M. Renaud, R. Rauth, Axel Donath, A. W. Chen, M. Büchele, S. Eschbach, M. Barnard, Marek Jamrozy, J. Bolmont, Gianluca Giavitto, K. Bernlöhr, Helene Sol, V. Poireau, H. Odaka, M. Füßling, Jacek Niemiec, Rafal Moderski, C. Perennes, K. Egberts, Dieter Horns, Olaf Reimer, M. Lemoine-Goumard, J. Dyks, Ruizhi Yang, Francois Brun, Reinhard Schlickeiser, Zorawar Wadiasingh, M. Böttcher, Michael Kreter, S. Chandra, Paolo Marchegiani, P. Vincent, S. J. Fegan, A. Djannati-Ataï, V. Barbosa Martins, S. Raab, L. Dirson, F. Gaté, Kirsty Feijen, S. Bonnefoy, Constantin Steppa, Alexandre Marcowith, M. Zacharias, Rachel Simoni, Masanori Arakawa, Celine Armand, Thomas Murach, Joachim Hahn, T. Vuillaume, A. Schulz, Clemens Hoischen, A. A. Zdziarski, Ullrich Schwanke, V. Joshi, V. Sahakian, A. Carosi, F. Werner, F. Ait Benkhali, E. de Oña Wilhelmi, Anton Dmytriiev, Isak Delberth Davids, S. Schwemmer, Arnaud Mares, Andrea Santangelo, Jim Hinton, Roberta Zanin, C. Trichard, S. Sailer, Dmitry Khangulyan, P. J. Meintjes, Tom Armstrong, Matteo Cerruti, D. A. Sanchez, M. Seglar-Arroyo, P.-O. Petrucci, Johan Bregeon, R. J. White, J. Devin, F. Schüssler, M. Scalici, A. Priyana Noel, Domenico Tiziani, D. Malyshev, Tadayuki Takahashi, A.M. Taylor, Werner Hofmann, Michael Backes, Jonathan Mackey, Victor Doroshenko, Gilles Henri, Heike Prokoph, C. Moore, Q. Piel, Dorit Glawion, Tim Holch, E. Moulin, Tomasz Bulik, S. Caroff, D. Huber, Marion Spir-Jacob, G. Maurin, H. Iwasaki, A.S. Seyffert, Naomi Tsuji, D. Jankowsky, Gerard Fontaine, M. Katsuragawa, Andreas Quirrenbach, Hester Schutte, Riaan Steenkamp, Andreas Specovius, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, L. Mohrmann, C. van Rensburg, Misao Sasaki, D. J. van der Walt, M. Hörbe, T. Tavernier, E. Leser, P. T. O'Brien, B. Khélifi, G. Hermann, Regis Terrier, Carlo Romoli, Christo Venter, Y. A. Gallant, Atreyee Sinha, C. van Eldik, A. Zech, M. Mohamed, Garret Cotter, D. A. Prokhorov, K. Kosack, B. Peyaud, G. Pühlhofer, A. Reimer, Pierre Brun, Jean-Pierre Ernenwein, Johannes Veh, R. Blackwell, E. Ruiz-Velasco, G. Emery, S. Saito, Thomas Bylund, M. Tluczykont, Armelle Jardin-Blicq, Jacques Muller, Samuel Timothy Spencer, H. Abdalla, M. A. Kastendieck, G. Vasileiadis, Włodek Kluźniak, Krzysztof Katarzynski, Catherine Boisson, Christoph Deil, Mohanraj Senniappan, D. Berge, Paul J. Morris, Kleopas Shiningayamwe, Lenka Tomankova, Jason John Watson, V. Marandon, D. Gottschall, Thomas Lohse, G. Lamanna, Alexander von Humboldt Foundation, Southern California Earthquake Center, EGI Foundation, Science and Technology Facilities Council (UK), Australian Research Council, German Research Foundation, Japan Society for the Promotion of Science, University of Amsterdam, Federal Ministry of Education and Research (Germany), Austrian Science Fund, Knut and Alice Wallenberg Foundation, Max Planck Society, National Science Centre (Poland), Centre National de la Recherche Scientifique (France), Commissariat à l'Ènergie Atomique et aux Ènergies Alternatives (France), Helmholtz Association, National Commission on Research Science and Technology (Namibia), University of Namibia, Federal Ministry of Education, Science and Research (Austria), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), H.E.S.S., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, H.E.S.S. Collaboration, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: individual: η CarStars: Wolf-Rayet [Stars], Photon, stars: individual: η Car, Astrophysics::High Energy Astrophysical Phenomena, Flux, Cosmic ray, Astrophysics, 01 natural sciences, cosmic rays, 0103 physical sciences, individual: η Car [stars], High Energy Stereoscopic System, 010303 astronomy & astrophysics, Cosmic rays, Colliding-wind binary, Astroparticle physics, Physics, Spectral index, non-thermal [Radiation mechanisms], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], general [Binaries], 010308 nuclear & particles physics, Astronomy and Astrophysics, radiation mechanisms: non-thermal, Wolf-Rayet [stars], binaries: general, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], astroparticle physics, ddc:520, HESS - Abteilung Hinton, stars: Wolf-Rayet, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Stars: individual: η CarStars: Wolf-Rayet, Noise (radio)
Abstract: Aims. Colliding wind binary systems have long been suspected to be high-energy (HE; 100 MeV < E < 100 GeV) {\gamma}-ray emitters. {\eta} Car is the most prominent member of this object class and is confirmed to emit phase-locked HE {\gamma} rays from hundreds of MeV to ~100 GeV energies. This work aims to search for and characterise the very-high-energy (VHE; E >100 GeV) {\gamma}-ray emission from {\eta} Car around the last periastron passage in 2014 with the ground-based High Energy Stereoscopic System (H.E.S.S.). Methods. The region around {\eta} Car was observed with H.E.S.S. between orbital phase p = 0.78 - 1.10, with a closer sampling at p {\approx} 0.95 and p {\approx} 1.10 (assuming a period of 2023 days). Optimised hardware settings as well as adjustments to the data reduction, reconstruction, and signal selection were needed to suppress and take into account the strong, extended, and inhomogeneous night sky background (NSB) in the {\eta} Car field of view. Tailored run-wise Monte-Carlo simulations (RWS) were required to accurately treat the additional noise from NSB photons in the instrument response functions. Results. H.E.S.S. detected VHE {\gamma}-ray emission from the direction of {\eta} Car shortly before and after the minimum in the X-ray light-curve close to periastron. Using the point spread function provided by RWS, the reconstructed signal is point-like and the spectrum is best described by a power law. The overall flux and spectral index in VHE {\gamma} rays agree within statistical and systematic errors before and after periastron. The {\gamma}-ray spectrum extends up to at least ~400 GeV. This implies a maximum magnetic field in a leptonic scenario in the emission region of 0.5 Gauss. No indication for phase-locked flux variations is detected in the H.E.S.S. data., Comment: 9 pages, 4 figures, 3 tables, in press with A&A
Published: 2020

16. A very-high-energy component deep in the $\gamma$-ray burst afterglow

Author: H. Abdalla, R. Adam, F. Aharonian, F. Ait Benkhali, E. O. Angüner, M. Arakawa, C. Arcaro, C. Armand, H. Ashkar, M. Backes, V. Barbosa Martins, M. Barnard, Y. Becherini, D. Berge, K. Bernlöhr, E. Bissaldi, R. Blackwell, M. Böttcher, C. Boisson, J. Bolmont, S. Bonnefoy, J. Bregeon, M. Breuhaus, F. Brun, P. Brun, M. Bryan, M. Büchele, T. Bulik, T. Bylund, M. Capasso, S. Caroff, A. Carosi, S. Casanova, M. Cerruti, T. Chand, S. Chandra, A. Chen, S. Colafrancesco, M. Curyło, I. D. Davids, C. Deil, J. Devin, P. deWilt, L. Dirson, A. Djannati-Ataï, A. Dmytriiev, A. Donath, V. Doroshenko, J. Dyks, K. Egberts, G. Emery, J.-P. Ernenwein, S. Eschbach, K. Feijen, S. Fegan, A. Fiasson, G. Fontaine, S. Funk, M. Füßling, S. Gabici, Y. A. Gallant, F. Gaté, G. Giavitto, L. Giunti, D. Glawion, J. F. Glicenstein, D. Gottschall, M.-H. Grondin, J. Hahn, M. Haupt, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, W. Hofmann, C. Hoischen, T. L. Holch, M. Holler, D. Horns, D. Huber, H. Iwasaki, M. Jamrozy, D. Jankowsky, F. Jankowsky, A. Jardin-Blicq, I. Jung-Richardt, M. A. Kastendieck, K. Katarzyński, M. Katsuragawa, U. Katz, D. Khangulyan, B. Khélifi, J. King, S. Klepser, W. Kluźniak, Nu. Komin, K. Kosack, D. Kostunin, M. Kreter, G. Lamanna, A. Lemière, M. Lemoine-Goumard, J.-P. Lenain, E. Leser, C. Levy, T. Lohse, I. Lypova, J. Mackey, J. Majumdar, D. Malyshev, V. Marandon, A. Marcowith, A. Mares, C. Mariaud, G. Martí-Devesa, R. Marx, G. Maurin, P. J. Meintjes, A. M. W. Mitchell, R. Moderski, M. Mohamed, L. Mohrmann, C. Moore, E. Moulin, J. Muller, T. Murach, S. Nakashima, M. de Naurois, H. Ndiyavala, F. Niederwanger, J. Niemiec, L. Oakes, P. O’Brien, H. Odaka, S. Ohm, E. de Ona Wilhelmi, M. Ostrowski, I. Oya, M. Panter, R. D. Parsons, C. Perennes, P.-O. Petrucci, B. Peyaud, Q. Piel, S. Pita, V. Poireau, A. Priyana Noel, D. A. Prokhorov, H. Prokoph, G. Pühlhofer, M. Punch, A. Quirrenbach, S. Raab, R. Rauth, A. Reimer, O. Reimer, Q. Remy, M. Renaud, F. Rieger, L. Rinchiuso, C. Romoli, G. Rowell, B. Rudak, E. Ruiz-Velasco, V. Sahakian, S. Sailer, S. Saito, D. A. Sanchez, A. Santangelo, M. Sasaki, R. Schlickeiser, F. Schüssler, A. Schulz, H. M. Schutte, U. Schwanke, S. Schwemmer, M. Seglar-Arroyo, M. Senniappan, A. S. Seyffert, N. Shafi, K. Shiningayamwe, R. Simoni, A. Sinha, H. Sol, A. Specovius, M. Spir-Jacob, Ł. Stawarz, R. Steenkamp, C. Stegmann, C. Steppa, T. Takahashi, T. Tavernier, A. M. Taylor, R. Terrier, D. Tiziani, M. Tluczykont, C. Trichard, M. Tsirou, N. Tsuji, R. Tuffs, Y. Uchiyama, D. J. van der Walt, C. van Eldik, C. van Rensburg, B. van Soelen, G. Vasileiadis, J. Veh, C. Venter, P. Vincent, J. Vink, H. J. Völk, T. Vuillaume, Z. Wadiasingh, S. J. Wagner, R. White, A. Wierzcholska, R. Yang, H. Yoneda, M. Zacharias, R. Zanin, A. A. Zdziarski, A. Zech, A. Ziegler, J. Zorn, N. Żywucka, F. de Palma, M. Axelsson, O. J. Roberts, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Abdalla, H., Adam, R., Aharonian, F., Ait Benkhali, F., Anguner, E. O., Arakawa, M., Arcaro, C., Armand, C., Ashkar, H., Backes, M., Barbosa Martins, V., Barnard, M., Becherini, Y., Berge, D., Bernlohr, K., Bissaldi, E., Blackwell, R., Bottcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., Bregeon, J., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Buchele, M., Bulik, T., Bylund, T., Capasso, M., Caroff, S., Carosi, A., Casanova, S., Cerruti, M., Chand, T., Chandra, S., Chen, A., Colafrancesco, S., Curylo, M., Davids, I. D., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Emery, G., Ernenwein, J. -P., Eschbach, S., Feijen, K., Fegan, S., Fiasson, A., Fontaine, G., Funk, S., Fussling, M., Gabici, S., Gallant, Y. A., Gate, F., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Heinzelmann, G., Henri, G., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horns, D., Huber, D., Iwasaki, H., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Jung-Richardt, I., Kastendieck, M. A., Katarzynski, K., Katsuragawa, M., Katz, U., Khangulyan, D., Khelifi, B., King, J., Klepser, S., Kluzniak, W., Komin, N., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P., Leser, E., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marcowith, A., Mares, A., Mariaud, C., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Mitchell, A. M. W., Moderski, R., Mohamed, M., Mohrmann, L., Moore, C., Moulin, E., Muller, J., Murach, T., Nakashima, S., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., de Ona Wilhelmi, E., Ostrowski, M., Oya, I., Panter, M., Parsons, R. D., Perennes, C., Petrucci, P. -O., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Priyana Noel, A., Prokhorov, D. A., Prokoph, H., Puhlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Saito, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Schlickeiser, R., Schussler, F., Schulz, A., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spir-Jacob, M., Stawarz, L., Steenkamp, R., Stegmann, C., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Trichard, C., Tsirou, M., Tsuji, N., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Volk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., White, R., Wierzcholska, A., Yang, R., Yoneda, H., Zacharias, M., Zanin, R., Zdziarski, A. A., Zech, A., Ziegler, A., Zorn, J., Zywucka, N., de Palma, F., Axelsson, M., Roberts, O. J., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 30366755 - Chand, Tej B., 31125417 - Chandra, Sunil, 26403366 - Ndiyavala, Hambeleleni, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 10060499 - Van der Walt, Diederick Johannes, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, 34208968 - Zywucka-Hejzner, Natalia, 33379009 - Kreter, Michael, Faculty of Science, and High Energy Astrophys. & Astropart. Phys (API, FNWI)
Subjects: electron, Brightness, Photon, Astrophysics::High Energy Astrophysical Phenomena, brightness, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Radiation, gamma ray: burst, 7. Clean energy, 01 natural sciences, VHE, Transient astrophysical phenomena, 0103 physical sciences, synchrotron, ddc:530, 010303 astronomy & astrophysics, X-ray: flux, Astrophysics::Galaxy Astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Range (particle radiation), Multidisciplinary, 010308 nuclear & particles physics, particle: energy, photon, Gamma ray, Time-domain astronomy, Institut für Physik und Astronomie, Afterglow, High-energy astrophysics, Automatic Keywords, gamma ray: UHE, Orders of magnitude (time), 13. Climate action, Gamma-ray burst, Particle astrophysics, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Gamma-ray bursts (GRBs) are brief flashes of gamma rays, considered to be the most energetic explosive phenomena in the Universe. The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow -- produced by the interaction between the ejected matter and the circumburst medium -- slows down, and a gradual decrease in brightness is observed. GRBs typically emit most of their energy via gamma-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments. However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elussive. Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow -ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and gamma-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies., Comment: Preprint version of Nature paper. Contacts: E.Ruiz-Velasco, F. Aharonian, E.Bissaldi, C.Hoischen, R.D Parsons, Q.Piel, A.Taylor, D.Khangulyan
Published: 2019

17. Combined Dark Matter searches towards dwarf spheroidal galaxies with Fermi-LAT, HAWC, HESS, MAGIC and VERITAS

Author: Dirk Lennarz, Luis Villaseñor, Gernot Maier, Anne Lemiere, Daniel Rosa-Gonzalez, Samuel Timothy Spencer, Wystan Benbow, Victor Barbosa Martins, Raul Prado, Arache Djannati-Ataï, Regis Terrier, Dan Parsons, Francisco Salesa Greus, Dmitriy Kostunin, Joshua Wood, Carlo Romoli, César Alvarez, Carlo van Rensburg, Massimo Capasso, Sajan Kumar, P. Reichherzer, Anton Dmytriiev, Stefan Ohm, Chiara Giuri, Brian van Soelen, G. Peron, Christian Stegmann, Emma Ona-Wilhelmi, S. J. Fegan, Alison Peisker, Hawc, Garret Cotter, Gary Gillanders, Zhiqiu Huang, Krzysztof Katarzynski, Filiberto Hueyotl-Zahuantitla, Ian Herzog, D. A. Prokhorov, K. Kosack, Halim Ashkar, Fabian Leuschner, Manami Sasaki, Michael Schneider, Joe Lundeen, Markus Boettcher, Brian Humensky, Isak Delberth Davids, A. Fiasson, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, David Kieda, Michael DuVernois, Albert Seyffert, Gianluca Giavitto, Qi Feng, Andreas Specovius, Andrew James Smith, Catherine Boisson, L. Mohrmann, Roberta Zanin, Marek Jamrozy, Tomás Capistrán Rojas, K. Nakashima, Jamie Holder, Hao Zhou, Thomas Lohse, Mireia Nievas-Rosillo, Samuel Zouari, Ira Jung, Sebastian Panny, K. Bernloehr, Deivid Ribeiro, Andrea Santangelo, Kristi Engel, Josefa Becerra Gonzalez, Thomas Tavernier, Ke Fang, Rishi Babu, Yu Wun Wong, Gerd J. Kunde, Jean-Pierre Ernenwein, Henrike Fleischhack, P. T. O'Brien, Clemens Hoischen, A. A. Zdziarski, Kelly Malone, Helene Sol, Markus Holler, Manel Errando, Atreyee Sinha, Francois Brun, Heinrich J. Völk, Sumari Hattingh, Kirsten Tollefson, Johann van der Walt, Q. Remy, Felix Jankowsky, Samridha Kunwar, Johannes Veh, M. Fuessling, P. Vincent, Harm Schoorlemmer, Stefano Gabici, Miguel Mostafa, Tyler Williamson, Jacek Niemiec, Michal Ostrowski, J.-P. Lenain, Israel Martinez Castellanos, Felix Aharonian, Tadayuki Takahashi, Gerd Puehlhofer, Lei Sun, Jesús Martínez-Castro, Pooja Surajbali, Andrés Sandoval, Hugh Spackman, Takaaki Tanaka, Segev BenZvi, Alexandre Marcowith, Felix Werner, Olaf Reimer, Vincent Marandon, Alberto Carramiñana, S. Steinmassl, Mary Kertzman, Hannes Thiersen, Victor Doroshenko, Michael Backes, Hannah Jhee, G. Lamanna, Marcos Santander, Angel Noel, W. Jin, Gus Sinnis, B. Rudak, Alasdair E. Gent, Kathrin Egberts, Jonathan Mackey, Fernando Ureña-Mena, Paolo Marchegiani, Sonal Ramesh Patel, Laenita Lorraine Oberholzer, Tim Holch, Sami Caroff, Heiko Salzmann, E. Kasai, Alison Mitchell, Gregory Foote, Nukri Komin, Tom Armstrong, Michelle Hui, Ruo-Yu Shang, Binita Hona, Raquel Diaz Hernandez, Vardan Baghmanyan, Celine Armand, Alejandro Lara, David Berley, Hector Rueda Ricarte, Nissim Illich Fraija, Naomi Tsuji, Gaurang Yodh, Stefan Funk, Alicja Wierzcholska, Conor McGrath, Gerard Fontaine, C. Moore, Vikas Joshi, Dorit Glawion, T. Chand, M. U. Nisa, M.-H. Grondin, Arnaud Mares, David Sanchez, Ernesto Belmont-Moreno, Thomas Murach, Eucario Gonzalo Pérez Pérez, Paul Reynolds, Ignacio Taboada, Xiaojie Wang, Lucy Fortson, Martin Tluczykont, Thomas Brian Humensky, Juan de Dios Álvarez Romero, Robert Ellsworth, Hester Schutte, Justine Devin, Constantin Steppa, Richard White, Rachel Simoni, Karen S. Caballero Mora, Elisa Pueschel, Jason Fan, Tomasz Bulik, Lukas Nellen, Malgorzata Curlo, Lente Dreyer, J. Patrick Harding, Gilles Maurin, Humberto Martínez Huerta, Riaan Steenkamp, Arnulfo Zepeda, Johannes Schaefer, Werner Hofmann, Jim Hinton, Michael Punch, S. Sailer, Dmitry Khangulyan, Sergio Hernández Cadena, Charles Thorpe-Morgan, M. Hörbe, Stephan O'Brien, Ramin Marx, John L. Quinn, J. F. Glicenstein, V. Sahakian, M. Panter, Mora Durocher, U. Katz, Jacco Vink, Umberto Cotti, Tobias Kleiner, Petra Hüntemeyer, David Huber, Ullrich Schwanke, Diego Garcia Aguilar, Vladimir Vassiliev, Oscar Martinez, J. Bolmont, Cederik León de León, Brian Fick, Laura Olivera-Nieto, A. Yusafzai, David Hanna, James Buckley, Lorenzo Diaz, Yves Gallant, Guillermo García-Torales, Arun Babu Kollamparambil, James Ryan, Kayla Farrell, Sabrina Casanova, Bruno Khelifi, María Catalina Espinoza Hernández, Jorge Antonio Morales Soto, Mateo Fernandez Alonso, Matthew Lundy, Faical Ait-Benkhali, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Jorge Luis Flores, Ibrahim Torres, Jordan A. Goodman, Anita Reimer, Adam Otte, Eduardo Moreno Barbosa, M. J. Lang, Frank M. Rieger, Elijah Willox, Colin Adams, Pedro Miranda-Romagnoli, Louis Du Plessis, Andrea Albert, Orel Gueta, Anna Barnacka, Brenda Dingus, Gašper Kukec Mezek, Hazal Goksu, Jorge Cotzomi, William H. Lee, Ruben Alfaro, Glenn Sembroski, David A. Williams, Eduardo de la Fuente, Anu Kundu, Dezhi Huang, Brian Reville, Connor Duffy, Edna Ruiz-Velasco, Anna Luashvili, Alisha Chromey, Konstantin Pfrang, L. Giunti, Philip Kaaret, Maria Magdalena González, Olivier Hervet, Hermes Leon Vargas, Sébastien Le Stum, Amanda Weinstein, Aryeh Brill, James Davies, Ken Ragan, Santiago Pita, Juan Carlos Arteaga Velazquez, Jason Lee, Sabrina Einecke, Lukasz Stawarz, Iryna Lypova, Julie McEnery, Sara Coutiño de Leon, Dieter Horns, R. J. Tuffs, Christo Venter, Meghan Tanner, Monica Barnard, B. Bi, Yvonne Becherini, Colas Rivière, Iftach Sadeh, Lott Frans, Mischa Breuhaus, Pauline Chambery, C. Levy, Jose Luis García-Luna, Michelle Tsirou, D. Malyshev, Ramiro Torres Escobedo, Hassan Abdalla, Hambeleleni Ndiyavala, Chang Dong Rho, Jhilik Majumdar, Martin Pohl, Mathieu Bony, Oguzhan Anguener, Hend Yassin, Gwenael Giacinti, Manuel Meyer, Arturo Iriarte, John Matthews, Kirsty Feijen, Ahron S. Barber, Floriane Cangemi, Fernando Garfias, R. A. Ong, Thomas Weisgarber, Thomas Bylund, Gilgamesh Luis-Raya, Rowan Batzofin, Mathieu Naurois, Jacques Muller, Avery Archer, Andreas Quirrenbach, Anushka Udara Abeysekara, José Serna-Franco, Hugo Alberto Ayala Solares, Davit Zargaryan, Rubén López-Coto, Reshmi Mukherjee, Andreas Zmija, Guillem Marti'i-Devesa, Sameer Patel, M. Lemoine-Goumard, Roberto Noriega-Papaqui, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Michael Kreter, Yunior Pérez Araujo, Anna Lia Longinotti, Michael Zacharias, Kleopas Shiningayamwe, Robert Brose, Fabian Schüssler, Emmanuel Moulin, Patrick Moriarty, Edna Ruiz Velasco, Michael Newbold, Oscar Chaparro-Amaro, J. T. Linnemann, Lenka Tomankova, Jodi Christiansen, Jaqueline Catalano, Ian James Watson, R. Konno, Andrew Taylor, C. Arcaro, Jason John Watson, Gavin Rowell, Daniel Omar Avila Rojas, Denys Malyshev, Emmet Roache, Rhiannon Turner, Chad Brisbois, Mohanraj Senniappan, José Roberto Angeles Camacho, Daniel Nieto, V. Poireau, Jimmy N.S. Shapopi, G. Vasileiadis, Hannah Dalgleish, donggeun tak, Juan Carlos Díaz Vélez, Armelle Jardin-Blicq, N. Zywucka, Abe Falcone, Nicola Omodei, Matthieu Renaud, German Hermann, Paul Morris, Maria Haupt, Stefan Klepser, Christopher van Eldik, Rafal Moderski, Alessandro Montanari, Amy Furniss, Sylvia Zhu, P. J. Meintjes, David Berge, Jose Andres Garcia-Gonzalez, Humberto Ibarguen Salazar, Wayne Robert Springer, Heike Prokoph, Marion Spir-Jacob, Amid Nayerhoda, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire d'Annecy de Physique des Particules (LAPP), Fermi-LAT, HAWC, H.E.S.S., MAGIC, and VERITAS
Subjects: Cherenkov detector, air, Cherenkov counter: water, Physics beyond the Standard Model, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, satellite, FOS: Physical sciences, IACT, Astrophysics, 01 natural sciences, GLAST, dark matter, law.invention, law, HESS, 0103 physical sciences, 010306 general physics, Cherenkov radiation, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Annihilation, 010308 nuclear & particles physics, background, new physics, imaging, sensitivity, MAGIC, Galaxy, Automatic Keywords, annihilation, VERITAS, galaxy, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], statistical, HAWC, Fermi Gamma-ray Space Telescope
Abstract: 36th International Cosmic Ray Conference, ICRC2019, Madison, USA, 24 Jul 2019 - 1 Aug 2019; 9 pages (2019)., The search for Dark Matter (DM) has great potential to reveal physics beyond the Standard Model. As such, searches for evidence of DM particles are being carried out using a wide range of techniques, such as direct searches for DM particles, searches for DM produced with colliders, and indirect searches for the Standard Model annihilation products of DM. Dwarf spheroidal galaxies (dSphs) are excellent targets for indirect Dark Matter searches due to their relatively high DM content and negligible expected astrophysical background. A collaboration was formed to maximise the sensitivity of DM searches towards dSphs by combining for the first time dSph data from three imaging air Cherenkov telescope (IACT) arrays: HESS, MAGIC, and VERITAS; the Fermi-LAT satellite, and the water Cherenkov detector HAWC. Due to the diverse nature of the instruments involved, each experiment will analyse their individual datasets from multiple targets and then the results will be combined at the likelihood level. For consistency of the likelihoods across the five experiments, a common approach is used to treat the astrophysical factor (J-Factor) for each target and an agreed set of annihilation channels are considered. We also agree on a common statistical approach and treatment of instrumental systematic uncertainties. The results are presented in terms of constraints on the velocity-weighted cross section for DM self-annihilation as a function of the DM particle mass.
Published: 2019
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18. P11.07 BRAF V600E mutation: has it a role in pediatric gliomas?

Author: L Giunti and Milena Guidi
Subjects: Cancer Research, education.field_of_study, business.industry, Population, medicine.disease, Malignancy, Genetic analysis, Therapeutic approach, Oncology, Glioma, medicine, Mutation testing, Cancer research, Neurology (clinical), business, education, Survival rate, POSTER PRESENTATIONS, Anaplastic astrocytoma
Abstract: Introduction: Pediatric high-grade gliomas (HGGs) represent a malignancy with a low survival rate. The genetic analysis of these tumors has identified useful mutations for an improved prognostic framing, as well as potential targets for new generation drugs. Previous studies have shown that the presence of BRAF V600E mutation in 23% of all pediatric gliomas reaching about 10% in WHO-grades III and IV, suggesting this alteration is one of the most common gene alterations in pediatric gliomas. BRAF mutation may help to differentiate indolent cancer from aggressive ones; tumors with BRAF V600E have a strong trend toward an increased risk for progression, developing a second cancer with anaplastic evolution. Moreover, BRAF mutation is a possible target for improved adjuvant treatment of residual or recurrent tumors. Materials and Methods: We performed a retrospective analysis of a population of pediatric patients with HGGs. Mutation analysis was carried out on DNA from each tumor sample. Portions coding and their flanking regions were amplified by PCR. The data were obtained after the purification of the samples and analysis by means of specific software. Results: We retrospectively evaluated 41 cases of pediatric HGGs. The median age at diagnosis was 7 years (range 0-32). The histological samples included: 9 cases of glioblastoma multiforme, 28 cases of anaplastic astrocytoma (AA), 3 glioneuronal tumor with neuropil-like islands (GTNI) and 1 glioma with mist components (2,45%). BRAF V600E mutation was analyzed in 27 samples: 21 patients did not have the mutation (77.77%), 6 patients showed the mutation (22,22). Four of 6 AA patients derived from a previous low grade tumor (3LGGs, and 1 GTNI) (p: 0.001). The BRAF V600E mutation seems therefore associated with increased risk of anaplastic progression. Finally, we have valuated the correlation between the presence of BRAF mutation and the tumor histology without statistically significant results (p: 0.12). Conclusions: The genetic analysis of tumor samples from children with HGGs represents an essential contribution to the prognostic stratification for each new diagnosis. BRAFV600E mutation is a negative prognostic factor in pediatric gliomas and a potential target of specific inhibitors. Considering the high rate of recurrence of these tumors and the limited impact on disease control of the following treatments, BRAF V600E detection is essential for a new therapeutic approach of poor responsive diseases.
Published: 2017

19. BIOLOGY

Author: J. H. Kim, H. B. Song, D. H. Kim, K. D. Park, B. J. Lee, S. Khatua, E. Kalkan, R. Brown, M. Pearlman, T. Vats, L. Abela, G. Fiaschetti, T. Shalaby, E. Grunder, M. Ma, J. Grahlert, M. Baumgartner, U. Siler, N. Nonoguchi, H. Ohgaki, M. Grotzer, J.-i. Adachi, T. Suzuki, K. Fukuoka, T. Yanagisawa, K. Mishima, T. Koga, M. Matsutani, R. Nishikawa, I. Sardi, L. Giunti, C. Bresci, S. Cardellicchio, M. Da Ros, A. M. Buccoliero, S. Farina, M. Arico, L. Genitori, M. Massimino, L. Filippi, A. Erdreich-Epstein, H. Zhou, X. Ren, M. Schur, T. B. Davidson, L. Ji, R. Sposto, S. Asgharzadeh, Y. Tong, E. White, M. Murugesan, B. Nimmervoll, M. Wang, D. Marino, D. Ellison, D. Finkelstein, S. Pounds, D. Malkin, R. Gilbertson, C. Eden, B. Ju, T. Phoenix, H. Poppleton, C. Lessman, M. Taylor, G. la Marca, S. Malvagia, V. Fratoni, M. G. Giovannini, F. Giangaspero, M. Badiali, V. Gleize, S. Paris, L. Moi, S. Elhouadani, A. Arcella, R. Morace, M. Antonelli, F. Buttarelli, K. Mokhtari, M. Sanson, S. Smith, J. Ward, M. Wilson, C. Rahman, F. Rose, A. Peet, D. Macarthur, R. Grundy, R. Rahman, S. Venkatraman, D. Birks, I. Balakrishnan, I. Alimova, P. Harris, P. Patel, N. Foreman, R. Vibhakar, H. Wu, Q. Zhou, D. Wang, G. Wang, D. Dang, E. Pencreach, A. Nguyen, E. Guerin, C. Lasthaus, D. Guenot, N. Entz-Werle, R. Unland, S. Schlosser, N. Farwick, T. Plagemann, G. Richter, H. Juergens, M. Fruehwald, C.-L. Chien, Y.-H. Lee, C.-I. Lin, J.-Y. Hsieh, S.-C. Lin, T.-T. Wong, D. M.-T. Ho, H.-W. Wang, S. Lagah, I.-L. Tan, S. Malcolm, Y. Majani, D. G. van Vuurden, E. Aronica, L. E. Wedekind, E. Hulleman, D. Biesmans, M. Bugiani, W. P. Vandertop, G. J. L. Kaspers, T. Wurdinger, D. P. Noske, P. M. Van der Stoop, S. Shukla, G. K. Kuipers, B. J. Slotman, J. Cloos, T. Sun, N. Warrington, J. Luo, S. Ganzhorn, U. Tabori, T. Druley, D. Gutmann, J. Rubin, P. Castelo-Branco, S. Choufani, S. Mack, D. Galagher, C. Zhang, T. Lipman, N. Zhukova, D. Martin, D. Merino, J. Wasserman, C. Samuel, N. Alon, J. Hitzler, J. C. Y. Wang, G. Keller, P. B. Dirks, S. Pfister, M. D. Taylor, R. Weksberg, P. Leblond, S. Meignan, A. Dewitte, F. Le Tinier, N. Wattez, E. Lartigau, A. Lansiaux, R. Hanson, I. Gordon, S. Zhao, K. Camphausen, K. Warren, N. M. Warrington, D. H. Gutmann, J. B. Rubin, M. Jaillet, Z. Kovacs, E. Martin-Fiori, M. Bernasconi, B. Werner, C. Dyberg, N. Baryawno, J. Milosevic, M. Wickstrom, P. A. Northcott, M. Kool, P. Kogner, J. I. Johnsen, G. Reynolds, N. Davies, T. Arvanitis, A. Zoghbi, M. Meisterernst, M. C. Fruehwald, K. Kerl, B. Orr, M. Haffner, W. Nelson, S. Yegnasubramanian, C. Eberhart, A. Fotovati, S. Abu-Ali, P.-S. Wang, L. Deleyrolle, C. Lee, J. Triscott, J. Chen, S. Franciosi, Y. Nakamura, Y. Sugita, T. Uchiumi, M. Kuwano, B. Leavitt, S. Singh, A. Jury, C. Jones, H. Wakimoto, B. Reynolds, C. Pallen, S. Dunn, S. Fletcher, J. Levine, M. Li, N. Kagawa, R. Hirayama, Y. Chiba, N. Kijima, H. Arita, M. Kinoshita, N. Hashimoto, S. Izumoto, M. Maruno, and T. Yoshimine
Subjects: Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published: 2012

20. Fuzzy predictive control for nitrogen removal in biological wastewater treatment

Author: Stefano Marsili-Libelli and L. Giunti
Subjects: Engineering, Environmental Engineering, Adaptive control, Denitrification, business.industry, Environmental engineering, Fuzzy control system, Fuzzy logic, Model predictive control, Wastewater, Process control, Sewage treatment, business, Water Science and Technology
Abstract: Whenever the carbon/nitrogen ratio of a domestic wastewater is too low, full denitrification is difficult to obtain and an additional source of organic carbon has to be provided. Since loading conditions may vary appreciably over the diurnal cycle, depending on the weather and sewage conditions, dosing should be controlled by an adaptive regulator to keep into account the time-varying process dynamics. A fuzzy predictive controller is proposed in this paper and its performance is tested through numerical simulations. The new aspects brought forward are the use of an improved model for denitrification, the use of benchmark (i.e. thoroughly tested and standardised) input files and the conclusion about regulator performance in overall plant performance, in terms of carbon saving and discharge compliance.
Published: 2002

21. ATYPICAL TERATOID RHABDOID TUMOR (ATRT)

Author: M. Hasselblatt, U. Kordes, J. Wolff, A. Jeibmann, M. Fruhwald, W. Paulus, S. Isken, R. Siebert, R. Schneppenheim, M. Benesch, G. Fleischhack, B. Gruhn, P.-G. Schlegel, O. Witt, W. Holter, A. Reiter, C. Urban, M. C. Fruhwald, L. Lafay-Cousin, A. Huang, C. Hawkins, C. Fryer, E. Bouffet, C. Kruchko, J. Propp, B. McCarthy, T. Dolecek, K. Kerl, R. Unland, H. Jurgens, M. W. Kieran, C. W. M. Roberts, J. A. Biegel, L. E. MacConaill, B. E. Rich, K. L. Ligon, S. Chi, A. Kondo, K. Shimoji, I. Ogino, F. Junya, S. Sakaguchi, M. Miyajima, H. Arai, I. Alimova, J. Knipstein, P. Harris, S. Venkataraman, V. Marquez, D. Birks, N. Foreman, R. Vibhakar, K. Bartelheim, M. Warmuth-Metz, R.-D. Kortmann, J. Gerss, D. Rizzo, P. Freneaux, H. Brisse, B. Parfait, F. Doz, C. Dufour, J.-L. Stephan, C. Edan, D. Ranchere-Vince, M. Peuchmaur, O. Delattre, F. Bourdeaut, S. Y. Soh, M. Y. Chan, W. T. Seow, K. Chang, W. H. Ng, A. M. Tan, K. Yamasaki, C. Tanaka, K. Okada, H. Fujisaki, Y. Osugi, J. Hara, Y. Matsusaka, H. Sakamoto, T. Inoue, P. Batchelder, B. K. DeMasters, M. Handler, D. Sumerauer, P. Vasovcak, A. Puchmajerova, M. Zapotocky, A. Vicha, M. Kyncl, J. Zamecnik, Z. Sedlacek, R. Kodet, O. Geludkova, E. Kumirova, A. Korshunov, Y. Kushel, A. Melikyan, L. Shishkina, M. Ryzhova, V. Ozerova, S. Gorbatyh, V. Popov, E. Pavlova, O. Scherbenko, I. Borodina, A. Donson, C. Dunham, E. Algar, D. Popovski, A. Muscat, D. Ashley, P. Modena, I. Sardi, M. Brenca, L. Giunti, R. Maestro, A. M. Buccoliero, B. Pollo, L. Genitori, F. Giangaspero, M. Massimino, V. Amani, A. Griesinger, L. Bemis, S. Schittone, D. Puccetti, D. Wargowski, L. Messiaen, N. Patel, S. Salamat, D. Rusinak, B. Iskandar, X. Lun, A. Jayanthan, P. Forsyth, and A. Narendran
Subjects: Cancer Research, Pathology, medicine.medical_specialty, Abstracts, Oncology, business.industry, Atypical teratoid rhabdoid tumor, medicine, Neurology (clinical), business, medicine.disease
Published: 2012

22. Subtyping mtDNA haplogroup H by SNaPshot minisequencing and its application in forensic individual identification

Author: Sarah Gino, Adriano Tagliabracci, Pierangela Grignani, G. Peloso, L Giunti, Chiara Turchi, Milena Alù, Carlo Previderè, Giovanni Beduschi, Carlo Robino, Ugo Ricci, and Alessandro Achilli
Subjects: Forensic Genetics, Mitochondrial DNA, Haplogroup H, MtDNA, primer extension methods, Single-nucleotide polymorphism, Biology, DNA, Mitochondrial, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Haplogroup, Pathology and Forensic Medicine, Humans, Multiplex, SNPs, haplogroups, HVS, DNA Primers, Genetics, mtDNA, Haplotype, Sequence Analysis, DNA, Complementarity Determining Regions, Subtyping, Forensic identification, Haplotypes, Italy, Primer extension methods, Haplogroups
Abstract: Sequence variation of the hypervariable segments (HVS) I/II of mitochondrial DNA (mtDNA) and the haplogroup affiliation were determined in a sample of 271 Italian subjects. This analysis showed that 42% of the individuals could be ascribed to H, the most frequent haplogroup in European Caucasian populations. This fraction was then screened for specific single nucleotide polymorphisms located in the coding region to identify H subclades H1-H15. We set up two multiplex polymerase chain reactions and specific SNaPshot assays to investigate the frequency distribution of these subgroups in our population sample and to examine their usefulness in discriminating among commonly shared HVS I/II sequences. This allowed the assignment of a large portion of the mtDNAs ( approximately 70%) to specific subhaplogroups, with H1 and H5 being the most represented. About two-thirds of the individuals sharing common HVS I/II sequences were subdivided and ascribed to specific H subhaplogroups with a significant reduction of the frequencies of the most common mtDNA haplotypes. Haplogroup H subtyping could thus be extremely useful in forensic identification when many samples have to be analysed and compared, avoiding excessive time-consuming and labor-intensive sequencing analysis.
Published: 2006

23. [Epigenetic study of Rett's syndrome as an adequate model for autistic disorders]

Author: I Iu, Iurov, S G, Vorsanova, V Iu, Voinova-Ulas, L, Villard, I A, Demidova, L, Giunti, M L, Guivabyccu-Uzielli, A V, Budilov, A K, Beresheva, P V, Novikov, and Iu V, Iurov
Subjects: Chromosomes, Human, X, Chromosomal Proteins, Non-Histone, Methyl-CpG-Binding Protein 2, DNA Mutational Analysis, Mutation, Missense, Mothers, Polymerase Chain Reaction, Pedigree, DNA-Binding Proteins, Repressor Proteins, Receptors, Androgen, Dosage Compensation, Genetic, Rett Syndrome, Humans, Point Mutation, Female, Child, Software
Abstract: Rett's syndrome (RTT) is a severe hereditary disorder of the nervous system. MECP2 gene mutations are considered as a primary cause of the disease. In the present study, we have found MECP2 mutations in 33 (84.6%) out of 39 RTT females. We have also studied X-inactivation patterns in 70 girls with RTT. A frequency of skewed X-inactivation was 37% (26 patients), being significantly higher (p0.001) than that in the controls. The investigation of inactivated X chromosome origin revealed that about 33% pairs had preferentially the inactivated maternal X chromosome. An abnormal type of chromosome X inactivation was observed in all RTT females. Thus, we conclude that skewed X-inactivation may be considered as a common feature of RTT. There is unambiguous evidence that epigenetic alterations in RTT are associated with MECP2 mutations. MeCP2 protein also appears to be involved in transcriptional regulation of chromosome X genes. RTT in females without MECP2 mutations is related to the epigenetic alterations. We suggest X chromosome inactivation study in RTT females and their mothers to be informative for investigation of genetic processes in RTT girls, even in case MECP2 mutations have not been found. RTT could be considered as an appropriate model for studying epigenetic abnormalities in relation to autistic spectrum disorders.
Published: 2005

24. Fuzzy predictive control for nitrogen removal in biological wastewater treatment

Author: S, Marsili-Libelli and L, Giunti
Subjects: Automation, Fuzzy Logic, Nitrogen, Computer Simulation, Pilot Projects, Carbon, Water Purification
Abstract: Whenever the carbon/nitrogen ratio of a domestic wastewater is too low, full denitrification is difficult to obtain and an additional source of organic carbon has to be provided. Since loading conditions may vary appreciably over the diurnal cycle, depending on the weather and sewage conditions, dosing should be controlled by an adaptive regulator to keep into account the time-varying process dynamics. A fuzzy predictive controller is proposed in this paper and its performance is tested through numerical simulations. The new aspects brought forward are the use of an improved model for denitrification, the use of benchmark (i.e. thoroughly tested and standardised) input files and the conclusion about regulator performance in overall plant performance, in terms of carbon saving and discharge compliance.
Published: 2002

25. Creation of Silicon-Vacancy Color Centers in Diamond by Ion Implantation

Author: S. Lagomarsino, A. M. Flatae, H. Kambalathmana, F. Sledz, L. Hunold, N. Soltani, P. Reuschel, S. Sciortino, N. Gelli, M. Massi, C. Czelusniak, L. Giuntini, and M. Agio
Subjects: diamond color centers, ion implantation, quantum emitters, single-photon sources, quantum sensors, nano-thermometry, Physics, QC1-999
Abstract: Silicon-vacancy (SiV) centers in diamond are gaining an increased interest for application, such as in quantum technologies and sensing. Due to the strong luminescence concentrated in its sharp zero-phonon line at room temperature, SiV centers are being investigated as single-photon sources for quantum communication, and also as temperature probes for sensing. Here, we discussed strategies for the fabrication of SiV centers in diamond based on Si-ion implantation followed by thermal activation. SiV color centers in high-quality single crystals have the best optical properties, but polycrystalline micro and nanostructures are interesting for applications in nano-optics. Moreover, we discuss the photoluminescence properties of SiV centers in phosphorous-doped diamond, which are relevant for the creation of electroluminescent devices, and nanophotonics strategies to improve the emission characteristics of the SiV centers. Finally, the optical properties of such centers at room and high temperatures show the robustness of the center and give perspectives for temperature-sensing applications.
Published: 2021
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26. Subtyping mtDNA haplogroup H by SNaPshot minisequencing and its application in forensic individual identification.

Author: P. Grignani, G. Peloso, A. Achilli, C. Turchi, A. Tagliabracci, M. Alù, G. Beduschi, U. Ricci, L. Giunti, C. Robino, S. Gino, and C. Previderè
Abstract: Sequence variation of the hypervariable segments (HVS) I/II of mitochondrial DNA (mtDNA) and the haplogroup affiliation were determined in a sample of 271 Italian subjects. This analysis showed that 42% of the individuals could be ascribed to H, the most frequent haplogroup in European Caucasian populations. This fraction was then screened for specific single nucleotide polymorphisms located in the coding region to identify H subclades H1–H15. We set up two multiplex polymerase chain reactions and specific SNaPshot assays to investigate the frequency distribution of these subgroups in our population sample and to examine their usefulness in discriminating among commonly shared HVS I/II sequences. This allowed the assignment of a large portion of the mtDNAs (∼70%) to specific subhaplogroups, with H1 and H5 being the most represented. About two-thirds of the individuals sharing common HVS I/II sequences were subdivided and ascribed to specific H subhaplogroups with a significant reduction of the frequencies of the most common mtDNA haplotypes. Haplogroup H subtyping could thus be extremely useful in forensic identification when many samples have to be analysed and compared, avoiding excessive time-consuming and labor-intensive sequencing analysis. [ABSTRACT FROM AUTHOR]
Published: 2006

27. Refractive index variation in a free-standing diamond thin film induced by irradiation with fully transmitted high-energy protons

Author: S. Lagomarsino, S. Calusi, M. Massi, N. Gelli, S. Sciortino, F. Taccetti, L. Giuntini, A. Sordini, M. Vannoni, F. Bosia, D. Gatto Monticone, P. Olivero, B. A. Fairchild, P. Kashyap, A. D. C. Alves, M. A. Strack, S. Prawer, and A. D. Greentree
Subjects: Medicine, Science
Abstract: Abstract Ion irradiation is a widely employed tool to fabricate diamond micro- and nano-structures for applications in integrated photonics and quantum optics. In this context, it is essential to accurately assess the effect of ion-induced damage on the variation of the refractive index of the material, both to control the side effects in the fabrication process and possibly finely tune such variations. Several partially contradictory accounts have been provided on the effect of the ion irradiation on the refractive index of single crystal diamond. These discrepancies may be attributable to the fact that in all cases the ions are implanted in the bulk of the material, thus inducing a series of concurrent effects (volume expansion, stress, doping, etc.). Here we report the systematic characterization of the refractive index variations occurring in a 38 µm thin artificial diamond sample upon irradiation with high-energy (3 MeV and 5 MeV) protons. In this configuration the ions are fully transmitted through the sample, while inducing an almost uniform damage profile with depth. Therefore, our findings conclusively identify and accurately quantify the change in the material polarizability as a function of ion beam damage as the primary cause for the modification of its refractive index.
Published: 2017
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28. Preoperative distraction in children: hand-held videogames vs clown therapy

Author: M. Messina, F. Molinaro, D. Meucci, R. Angotti, L. Giuntini, E. Cerchia, A.L. Bulotta, and E. Brandigi
Subjects: clowntherapy, children, surgery, videogames, Pediatrics, RJ1-570, Surgery, RD1-811
Abstract: Anxiety in children undergoing surgery is characterized by feelings of tension, apprehension, nervousness and fear which may manifest differently. Postoperative behavioural changes such as nocturnal enuresis, feeding disorders, apathy, and sleep disturbances may stem from postoperative anxiety. Some Authors pointed out that over 60% of children undergoing surgery are prone to developing behavioural alterations 2 weeks after surgery. Variables such as age, temperament and anxiety both in children and parents are considered predictors of such changes.1 Studies were published describing how psycho-behavioural interventions based on play, learning and entertainment in preparing children for surgery, may reduce preoperative anxiety. Clown-therapy is applied in the most important paediatric facilities and has proved to diminish children’s emotional distress and sufferance, as well as consumption of both analgesics and sedatives and to facilitate the achievement of therapeutic goals. The aim of our study was to evaluate the efficacy of clown-therapy during the child’s hospital stay, with a view to optimizing treatment and care, preventing behavioural alterations and enhancing the child’s overall life quality.
Published: 2014
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29. L'opposizione al Tav in Val di Susa

Author: Roccato M., MANNARINI, MINI, Mercalli L., Giunti L., Roccato, M., and Mannarini, Mini
Published: 2015

30. Generation of a human induced pluripotent stem cell line from a patient with GM3 synthase deficiency using self-replicating RNA vector.

Author: Tonin R, Feo F, Falliano S, Giunti L, Calamai M, Procopio E, Mari F, Sciruicchio V, Conti V, Fanelli I, Bambi F, Guerrini R, and Morrone A
Subjects: Humans, Female, Adolescent, Cell Line, RNA metabolism, RNA genetics, Genetic Vectors metabolism, Cell Differentiation, Induced Pluripotent Stem Cells metabolism, Sialyltransferases deficiency, Sialyltransferases genetics, Sialyltransferases metabolism
Abstract: GM3 synthase deficiency (GM3SD) is caused by biallelic variants in the ST3GAL5 gene. Early clinical features of GM3SD include infantile onset of severe irritability and feeding difficulties, early intractable seizures, growth failure, hypotonia, sensorineural hearing impairment. We describe the generation and characterization the human induced pluripotent stem cell (hiPSC) line derived from fibroblasts of a 13-year-old girl with GM3 synthase deficiency resulted compound heterozygous for two new variants in the ST3GAL5 gene, c.1166A > G (p.His389Arg) and the c.1024G > A (p.Gly342Ser). The generated hiPSC line shows a normal karyotype, expresses pluripotency markers, and is able to differentiate into the three germ layers., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)
Published: 2024
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31. Case report: complete long-lasting response to multimodal third line treatment with neurosurgical resection, carmustine wafer implantation and dabrafenib plus trametinib in a BRAFV600E mutated high-grade glioma.

Author: Castelli B, Tellini M, Guidi M, Di Nicola M, Giunti L, Buccoliero AM, Censullo ML, Iacono A, Desideri I, Genitori L, Sardi I, and Fonte C
Abstract: Dabrafenib plus trametinib is a promising new therapy for patients affected by BRAFV600E -mutant glioma, with high overall response and manageable toxicity. We described a complete and long-lasting response in a case of recurrent anaplastic pleomorphic xanthoastrocytoma CNS WHO-grade 3 BRAFV600E mutated. Due to very poor prognosis, there are a few described cases of high-grade glioma (HGG) patients treated with the combined target therapy as third-line treatment. The emergence of optimized sequencing strategies and targeted agents, including multimodal and systemic therapy with dabrafenib plus trametinib, will continue to broaden personalized therapy in HGG improving patient outcomes., Competing Interests: CF took part in the Advisory Board financed by Novartis on September 5th 2022 and she took part as principal investigator in CDRB436G2201 NCT02684058 study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Castelli, Tellini, Guidi, Di Nicola, Giunti, Buccoliero, Censullo, Iacono, Desideri, Genitori, Sardi and Fonte.)
Published: 2024
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32. Generation of human induced pluripotent stem cell line (AOUMEYi001-A) from a patient affected by Congenital disorders of glycosylation (ALG8-CDG) using self-replicating RNA vector.

Author: Tonin R, Feo F, Falliano S, Ferri L, Giunti L, Calamai M, Procopio E, Mari F, Conti V, Fanelli I, Bambi F, Guerrini R, and Morrone A
Subjects: Male, Humans, Adolescent, Glycosylation, Glucosyltransferases genetics, Mutation, Congenital Disorders of Glycosylation genetics, Induced Pluripotent Stem Cells metabolism
Abstract: Congenital Disorders of Glycosylation (CDG) are rare inherited metabolic diseases caused by genetic defects in the glycosylation of proteins and lipids. In this study, we describe the generation and characterization of one human induced pluripotent stem cell (hiPSC) line from a 15-year-old male patient with CDG. The patient carried three variants, one (c.122G > A; p.Arg41Gln) inherited from his father and two (c.445 T > G; p.Leu149Arg and the novel c.980C > G; p.Thr327Arg) inherited from his mother in the ALG8 gene (OMIM #608103). The generated hiPSC line shows a normal karyotype, expresses pluripotency markers, and is able to differentiate into the three germ layers., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)
Published: 2023
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33. Brief report: pediatric high-grade gliomas treated with vinorelbine and valproic acid added to temozolomide.

Author: Guidi M, Giunti L, Buccoliero AM, Fonte C, Scoccianti S, Censullo ML, Caporalini C, Tellini M, Di Nicola M, Castelli B, Greto D, Giordano F, Genitori L, and Sardi I
Abstract: Children and young adult with high grade gliomas (HGG) have dismal prognoses and treatment options remain limited. We present 19 patients diagnosed with anaplastic astrocytoma (AA) or glioblastoma (GBM) treated with concomitant and adjuvant 20-30 mg/m 2 /dose of vinorelbine and 30 mg/kg/day valproic acid (VA) in combination to consolidated TMZ and focal RT after maximal surgery. We evaluated the feasibility of treating children diagnosed with HGG. The median follow-up time was 51.4 months (range, 6.2-106.6 months). The 5-year OS was 57.9% (CI 95%, 33.2-76.3) and the 5-year PFS was 57.9% (CI 95%, 33.2-76.3). Eight patients (42.1%) have progressed so far, with a median time to progression of 9 months from diagnosis (range, 4.6-34.7 months). All of them died for disease progression. At time of analysis, 11 patients were still alive with no evidence of disease. It is notable that all events occurred within 35 months from the start of therapy. All 19 treated patients reported low-grade drug-related adverse events (AEs). The treatment was well tolerated in our limited cohort of patients without significant toxicity. Further studies of the efficacy and safety of combination of vinorelbine/VA to consolidated RT/TMZ therapy in children with HGG are underway in a clinical trial setting., Competing Interests: None., (AJCR Copyright © 2023.)
Published: 2023

34. A diamond detector based dosimetric system for instantaneous dose rate measurements in FLASH electron beams.

Author: Marinelli M, di Martino F, Del Sarto D, Pensavalle JH, Felici G, Giunti L, De Liso V, Kranzer R, Verona C, and Verona Rinati G
Subjects: Reproducibility of Results, Radiometry methods, Calibration, Diamond, Electrons
Abstract: Objective. A reliable determination of the instantaneous dose rate (I-DR) delivered in FLASH radiotherapy treatments is believed to be crucial to assess the so-called FLASH effect in preclinical and biological studies. At present, no detectors nor real-time procedures are available to do that in ultra high dose rate (UH-DR) electron beams, typically consisting of μ s pulses characterized by I-DRs of the order of MGy/s. A dosimetric system is proposed possibly overcoming the above reported limitation, based on the recently developed flashDiamond (fD) detector (model 60025, PTW-Freiburg, Germany). Approach. A dosimetric system is proposed, based on a flashDiamond detector prototype, properly modified and adapted for very fast signal transmission. It was used in combination with a fast transimpedance amplifier and a digital oscilloscope to record the temporal traces of the pulses delivered by an ElectronFlash linac (SIT S.p.A., Italy). The proposed dosimetric systems was investigated in terms of the temporal characteristics of its response and the capability to measure the absolute delivered dose and instantaneous dose rate (I-DR). A 'standard' flashDiamond was also investigated and its response compared with the one of the specifically designed prototype. Main results . Temporal traces recorded in several UH-DR irradiation conditions showed very good signal to noise ratios and rise and decay times of the order of a few tens ns, faster than the ones obtained by the current transformer embedded in the linac head. By analyzing such signals, a calibration coefficient was derived for the fD prototype and found to be in agreement within 1% with the one obtained under reference 60 Co irradiation. I-DRs as high as about 2 MGy s -1 were detected without any undesired saturation effect. Absolute dose per pulse values extracted by integrating the I-DR signals were found to be linear up to at least 7.13 Gy and in very good agreement with the ones obtained by connecting the fD to a UNIDOS electrometer (PTW-Freiburg, Germany). A good short term reproducibility of the linac output was observed, characterized by a pulse-to-pulse variation coefficient of 0.9%. Negligible differences were observed when replacing the fD prototype with a standard one, with the only exception of a somewhat slower response time for the latter detector type. Significance. The proposed fD-based system was demonstrated to be a suitable tool for a thorough characterization of UH-DR beams, providing accurate and reliable time resolved I-DR measurements from which absolute dose values can be straightforwardly derived., (Creative Commons Attribution license.)
Published: 2023
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35. SMARCE1-related meningiomas: A clear example of cancer predisposing syndrome.

Author: Fiorentini E, Giunti L, Di Rita A, Peraio S, Fonte C, Caporalini C, Buccoliero AM, Censullo ML, Gori G, Noris A, Pasquariello R, Battini R, Pavone R, Giordano F, Giglio S, and Rinaldi B
Subjects: Adolescent, Female, Humans, Chromosomal Proteins, Non-Histone genetics, DNA-Binding Proteins genetics, Germ-Line Mutation, Loss of Heterozygosity, Transcription Factors genetics, Meningeal Neoplasms genetics, Meningeal Neoplasms diagnosis, Meningeal Neoplasms pathology, Meningioma genetics, Meningioma diagnosis, Meningioma pathology
Abstract: We report the case of a 16-year-old girl presenting with spinal clear-cell multiple meningiomas (CCMs). In view of this presentation, we sequenced a bioinformatic panel of genes associated with susceptibility to meningioma, identifying a germline heterozygous variant in SMARCE1. Somatic DNA investigations in the CCM demonstrated the deletion of the wild-type allele (loss of heterozygosity, LOH), supporting the causative role of this variant. Family segregation study detected the SMARCE1 variant in the asymptomatic father and in the asymptomatic sister who, nevertheless, presents 2 spinal lesions. Germline heterozygous loss-of-function (LoF) variants in SMARCE1, encoding a protein of the chromatin-remodeling complex SWI/SNF, have been described in few familial cases of susceptibility to meningioma, in particular the CCM subtype. Our case confirms the role of NGS in investigating predisposing genes for meningiomas (multiple or recurrent), with specific regard to SMARCE1 in case of pediatric CCM. In addition to the age of onset, the presence of familial clustering or the coexistence of multiple synchronous meningiomas also supports the role of a genetic predisposition that deserves a molecular assessment. Additionally, given the incomplete penetrance, it is of great importance to follow a specific screening or follow-up program for symptomatic and asymptomatic carriers of pathogenic variants in SMARCE1., (Copyright © 2023 Elsevier Masson SAS. All rights reserved.)
Published: 2023
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36. Myxoid glioneuronal tumor: Histopathologic, neuroradiologic, and molecular features in a single center series.

Author: Caporalini C, Scagnet M, Giunti L, Cetica V, Mei D, Conti V, Moscardi S, Macconi L, Giordano F, D'Incerti L, Genitori L, Guerrini R, and Buccoliero AM
Subjects: Child, Humans, Magnetic Resonance Imaging, Septum Pellucidum pathology, Mutation, Receptor Protein-Tyrosine Kinases genetics, Disease Progression, Brain Neoplasms pathology
Abstract: Background: Myxoid glioneuronal tumor (MGT) is a benign glioneuronal neoplasm recently introduced in the World Health Organization (WHO) classification of the central nervous system (CNS) tumors. MGTs are typically located in the septum pellucidum, foramen of Monro or periventricular white matter of the lateral ventricle. They were previously diagnosed as dysembryoplastic neuroepithelial tumors (DNT), showing histological features almost indistinguishable from classical cortical DNT. Despite that, MGTs have been associated with a specific dinucleotide substitution at codon 385 in the platelet-derived growth factor receptor alpha (PDGFRA) gene, replacing a lysine residue with either leucine or isoleucine (p. LysK385Leu/Iso). This genetic variation has never been described in any other CNS tumor., Materials and Methods: Thirty-one consecutive tumors, previously diagnosed as DNTs at the Meyer Children's Hospital IRCCS between January 2010 and June 2021 were collected for a comprehensive study of their clinical, imaging, pathological features, and molecular profile., Results: In six out of the thirty-one tumors we had previously diagnosed as DNTs, we identified the recurrent dinucleotide mutation in the PDGFRA. All six tumors were typically located within the periventricular white matter of the lateral ventricle and in the septum pellucidum. We then renamed these lesions as MGT, according to the latest WHO CNS classification. In all patients we observed an indolent clinical course, without recurrence., Conclusion: MGT represent a rare but distinct group of neoplasm with a typical molecular profiling, a characteristic localization, and a relative indolent clinical course., Competing Interests: Declaration of Competing Interest None., (Copyright © 2023. Published by Elsevier Inc.)
Published: 2023
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37. Placental growth factor as a predictive marker of preeclampsia - PREBIO study - PREeclampsia BIOchemical study.

Author: Giardini V, Rovelli R, Algeri P, Giunti L, Lazzarin S, Callegari C, Roncaglia N, and Vergani P
Subjects: Biomarkers, Female, Humans, Placenta, Placenta Growth Factor, Predictive Value of Tests, Pregnancy, Prospective Studies, Vascular Endothelial Growth Factor Receptor-1, Pre-Eclampsia diagnosis
Abstract: Introduction: To evaluate the clinical utility of placental growth factor (PlGF) for the prediction of preeclampsia (PE)., Materials and Methods: This prospective cohort study included women divided into three groups: (1) pregnancies without preconceptional risk of developing PE; (2) pregnancies with a preconceptional and/or current risk of developing PE; (3) PE-complicated pregnancies (control group). Blood samples were collected every 4-5 weeks or during hospitalization from early second trimester until delivery in the group 1 and 2, at the diagnosis of PE in the group 3. Plasma levels of PlGF were measured using The Triage PlGF test (Alere) and considered pathological under the 5th centile for gestational age. Sensitivity (Sn), specificity (Sp), positive and negative predictive value (PPV, NPV) were calculated., Results: In group 1, 30% of women (3/10) had pathological test but none of them developed PE (Sp 70%, NPV 100%). In group 2 ( n = 75), none of the patients with normal test developed PE (0/24), while 39% of women with PlGF < 5th centile (20/51) developed PE (Sn 100%, Sp 44%, PPV 39%, NPV 100%). In group 3 ( n = 11) all women except one had a pathological PlGF test (Sn 90%, PPV 100%)., Conclusions: Our data support recent studies which identify PlGF as a biochemical marker not only of PE, but also of placental dysfunction. In fact, it is useful for ruling out PE in women at risk because of the high Sn and high NPV: a normal PlGF is related with a positive pregnancy outcome. Therefore, the measurement of this biomarker would simplify PE clinical management and would reduce costs.
Published: 2022
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38. Time-resolved hadronic particle acceleration in the recurrent nova RS Ophiuchi.

Author: Aharonian F, Ait Benkhali F, Angüner EO, Ashkar H, Backes M, Baghmanyan V, Barbosa Martins V, Batzofin R, Becherini Y, Berge D, Bernlöhr K, Bi B, Böttcher M, Boisson C, Bolmont J, de Bony de Lavergne M, Breuhaus M, Brose R, Brun F, Caroff S, Casanova S, Cerruti M, Chand T, Chen A, Cotter G, Damascene Mbarubucyeye J, Djannati-Ataï A, Dmytriiev A, Doroshenko V, Duffy C, Egberts K, Ernenwein JP, Fegan S, Feijen K, Fiasson A, Fichet de Clairfontaine G, Fontaine G, Füßling M, Funk S, Gabici S, Gallant YA, Ghafourizadeh S, Giavitto G, Giunti L, Glawion D, Glicenstein JF, Grondin MH, Hermann G, Hinton JA, Hörbe M, Hofmann W, Hoischen C, Holch TL, Holler M, Horns D, Huang Z, Jamrozy M, Jankowsky F, Jung-Richardt I, Kasai E, Katarzyński K, Katz U, Khangulyan D, Khélifi B, Klepser S, Kluźniak W, Komin N, Konno R, Kosack K, Kostunin D, Le Stum S, Lemière A, Lemoine-Goumard M, Lenain JP, Leuschner F, Lohse T, Luashvili A, Lypova I, Mackey J, Malyshev D, Malyshev D, Marandon V, Marchegiani P, Marcowith A, Martí-Devesa G, Marx R, Maurin G, Meyer M, Mitchell A, Moderski R, Mohrmann L, Montanari A, Moulin E, Muller J, Murach T, Nakashima K, de Naurois M, Nayerhoda A, Niemiec J, Priyana Noel A, O'Brien P, Ohm S, Olivera-Nieto L, de Ona Wilhelmi E, Ostrowski M, Panny S, Panter M, Parsons RD, Peron G, Pita S, Poireau V, Prokhorov DA, Prokoph H, Pühlhofer G, Punch M, Quirrenbach A, Reichherzer P, Reimer A, Reimer O, Renaud M, Reville B, Rieger F, Rowell G, Rudak B, Rueda Ricarte H, Ruiz-Velasco E, Sahakian V, Sailer S, Salzmann H, Sanchez DA, Santangelo A, Sasaki M, Schäfer J, Schüssler F, Schutte HM, Schwanke U, Senniappan M, Shapopi JNS, Simoni R, Sinha A, Sol H, Specovius A, Spencer S, Stawarz Ł, Steinmassl S, Steppa C, Takahashi T, Tanaka T, Taylor AM, Terrier R, Thorpe-Morgan C, Tsirou M, Tsuji N, Tuffs R, Uchiyama Y, Unbehaun T, van Eldik C, van Soelen B, Veh J, Venter C, Vink J, Wagner SJ, Werner F, White R, Wierzcholska A, Wong YW, Yusafzai A, Zacharias M, Zargaryan D, Zdziarski AA, Zech A, Zhu SJ, Zouari S, and Żywucka N
Abstract: Recurrent novae are repeating thermonuclear explosions in the outer layers of white dwarfs, due to the accretion of fresh material from a binary companion. The shock generated when ejected material slams into the companion star's wind can accelerate particles. We report very-high-energy (VHE; [Formula: see text]) gamma rays from the recurrent nova RS Ophiuchi, up to 1 month after its 2021 outburst, observed using the High Energy Stereoscopic System (H.E.S.S.). The temporal profile of VHE emission is similar to that of lower-energy giga-electron volt emission, indicating a common origin, with a 2-day delay in peak flux. These observations constrain models of time-dependent particle energization, favoring a hadronic emission scenario over the leptonic alternative. Shocks in dense winds provide favorable environments for efficient acceleration of cosmic rays to very high energies.
Published: 2022
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39. Pediatric High Grade Glioma Classification Criteria and Molecular Features of a Case Series.

Author: Buccoliero AM, Giunti L, Moscardi S, Castiglione F, Provenzano A, Sardi I, Scagnet M, Genitori L, and Caporalini C
Subjects: Child, Humans, Glioma genetics, Glioma pathology
Abstract: Pediatric high-grade gliomas (pHGGs) encompass a heterogeneous group of tumors. Three main molecular types (H3.3 mutant, IDH mutant, and H3.3/IDH wild-type) and a number of subtypes have been identified. We provide an overview of pHGGs and present a mono-institutional series. We studied eleven non-related pHGG samples through a combined approach of routine diagnostic tools and a gene panel. TP53 and H3F3A were the most mutated genes (six patients each, 54%). The third most mutated gene was EGFR (three patients, 27%), followed by PDGFRA and PTEN (two patients each, 18%). Variants in the EZHIP, MSH2, IDH1, IDH2, TERT, HRAS, NF1, BRAF, ATRX, and PIK3CA genes were relatively infrequent (one patient each, 9%). In one case, gene panel analysis documented the presence of a pathogenic IDH2 variant (c.419G>A, p.Arg140Gln) never described in gliomas. More than one-third of patients carry a variant in a gene associated with tumor-predisposing syndromes. The absence of constitutional DNA did not allow us to identify their constitutional origin.
Published: 2022
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40. STOP Pain Project-Opioid Response in Pediatric Cancer Patients and Gene Polymorphisms of Cytokine Pathways.

Author: Crescioli G, Lombardi N, Vagnoli L, Bettiol A, Giunti L, Cetica V, Coniglio ML, Provenzano A, Giglio S, Bonaiuti R, Mugelli A, Aricò M, Messeri A, Vannacci A, and Maggini V
Abstract: Moderate to severe cancer pain treatment in children is based on the use of weak and strong opioids. Pharmacogenetics play a central role in developing personalized pain therapies, as well as avoiding treatment failure and/or intolerable adverse drug reactions. This observational study aimed to investigate the association between IL-6, IL-8, and TNFα genetic single nucleotide polymorphisms (SNPs) and response to opioid therapy in a cohort of pediatric cancer patients. Pain intensity before treatment (PIt0) significantly differed according to IL-6 rs1800797 SNP, with a higher PI for A/G and G/G individuals (p = 0.017), who required a higher dose of opioids (p = 0.047). Moreover, compared to G/G subjects, heterozygous or homozygous individuals for the A allele of IL-6 rs1800797 SNP had a lower risk of having a PIt0 > 4. Dose24h and Dosetot were both higher in G/G individuals for TNFα rs1800629 (p = 0.010 and p = 0.031, respectively), while risk of having a PIt0 > 4 and a ∆VAS > 2 was higher for G/G subjects for IL-6 rs1800795 SNP compared to carriers of the C allele. No statistically significant association between genotypes and safety outcomes was found. Thus, IL-6 and TNFα SNPs could be potential markers of baseline pain intensity and opioid dose requirements in pediatric cancer patients.
Published: 2022
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41. Clinical-pathological study of 28 glial and mixed neuronal-glial tumors diagnosed within the first year of life.

Author: Buccoliero AM, Caporalini C, Moscardi S, Spacca B, Scagnet M, Castiglione F, Sardi I, Giunti L, and Genitori L
Subjects: Adolescent, Child, Humans, Astrocytoma diagnosis, Astrocytoma genetics, Brain Neoplasms diagnosis, Brain Neoplasms genetics, Ganglioglioma diagnosis, Ganglioglioma genetics, Glioblastoma, Glioma diagnosis, Glioma genetics
Abstract: Our purpose was to investigate the incidence of gliomas and neuronal-glial tumors, their outcome, and H3.3K27M, BRAFV600E, and IDH status in children within 1 year of age affected by CNS tumor. We collected 28 consecutive gliomas and mixed tumors. Immunohistochemistry and/or molecular analyses were performed on formalin-fixed/paraffin-embedded specimens. 24 (86%) tumors were supratentorial. 15 (54%) tumors were astrocytomas (5 glioblastomas, 1 anaplastic astrocytoma, 1 pilocytic astrocytoma, 3 pilomixoid astrocytomas, 2 subependymal giant cell astrocytomas, 3 astrocytomas not otherwise specified (NOS)), 4 (14%) were anaplastic ependymomas, and 9 (32%) were mixed tumors (5 gangliogliomas, 2 gangliocytomas, 2 desmoplastic infantile gangliogliomas (DIGs)). Alive patients were: 4 (67%) affected by high-grade astrocytoma (mean follow-up 64 months), 4 (67%) affected by low-grade astrocytoma (mean follow-up 83 months), 2 (67%) affected by astrocytoma NOS (mean follow-up 60 months), 1 (25%) affected by anaplastic ependymoma (follow-up 12 months), and 9 (100%) affected by mixed tumors (mean follow-up 74 months). H3.3K27M and IDH were not-mutated in any tumor (100%). BRAFV600E mutation was documented in 6 (21%) tumors (4 gangliogliomas, 1 gangliocytoma, and 1 astrocytoma NOS resulted as anaplastic pleomorphic xanthoastrocytoma 8 years later). Gliomas and mixed tumors diagnosed within 1 year of age are morphologically heterogeneous. Moreover, analogously to those affecting older children, they are IDH1-2 and H3.3K27M (when located outside midline) not-mutated while BRAFV600E mutation is typical of gangliogliomas/gangliocytomas and pleomorphic xanthoastrocytomas. High-grade astrocytomas have a more favorable prognosis compared with the same lesions occurring later in life while ependymomas have a poorer outcome.
Published: 2022
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42. Hippo Pathway in Regulating Drug Resistance of Glioblastoma.

Author: Casati G, Giunti L, Iorio AL, Marturano A, Galli L, and Sardi I
Subjects: Humans, Drug Resistance, Neoplasm genetics, Glioblastoma genetics, Glioblastoma metabolism, Glioblastoma pathology, Hippo Signaling Pathway genetics, Neoplasm Proteins genetics, Neoplasm Proteins metabolism
Abstract: Glioblastoma (GBM) represents the most common and malignant tumor of the Central Nervous System (CNS), affecting both children and adults. GBM is one of the deadliest tumor types and it shows a strong multidrug resistance (MDR) and an immunosuppressive microenvironment which remain a great challenge to therapy. Due to the high recurrence of GBM after treatment, the understanding of the chemoresistance phenomenon and how to stimulate the antitumor immune response in this pathology is crucial. The deregulation of the Hippo pathway is involved in tumor genesis, chemoresistance and immunosuppressive nature of GBM. This pathway is an evolutionarily conserved signaling pathway with a kinase cascade core, which controls the translocation of YAP (Yes-Associated Protein)/TAZ (Transcriptional Co-activator with PDZ-binding Motif) into the nucleus, leading to regulation of organ size and growth. With this review, we want to highlight how chemoresistance and tumor immunosuppression work in GBM and how the Hippo pathway has a key role in them. We linger on the role of the Hippo pathway evaluating the effect of its de-regulation among different human cancers. Moreover, we consider how different pathways are cross-linked with the Hippo signaling in GBM genesis and the hypothetical mechanisms responsible for the Hippo pathway activation in GBM. Furthermore, we describe various drugs targeting the Hippo pathway. In conclusion, all the evidence described largely support a strong involvement of the Hippo pathway in gliomas progression, in the activation of chemoresistance mechanisms and in the development of an immunosuppressive microenvironment. Therefore, this pathway is a promising target for the treatment of high grade gliomas and in particular of GBM.
Published: 2021
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43. Revealing x-ray and gamma ray temporal and spectral similarities in the GRB 190829A afterglow.

Author: Abdalla H, Aharonian F, Ait Benkhali F, Angüner EO, Arcaro C, Armand C, Armstrong T, Ashkar H, Backes M, Baghmanyan V, Barbosa Martins V, Barnacka A, Barnard M, Becherini Y, Berge D, Bernlöhr K, Bi B, Bissaldi E, Böttcher M, Boisson C, Bolmont J, de Bony de Lavergne M, Breuhaus M, Brun F, Brun P, Bryan M, Büchele M, Bulik T, Bylund T, Caroff S, Carosi A, Casanova S, Chand T, Chandra S, Chen A, Cotter G, Curyło M, Damascene Mbarubucyeye J, Davids ID, Davies J, Deil C, Devin J, Dirson L, Djannati-Ataï A, Dmytriiev A, Donath A, Doroshenko V, Dreyer L, Duffy C, Dyks J, Egberts K, Eichhorn F, Einecke S, Emery G, Ernenwein JP, Feijen K, Fegan S, Fiasson A, Fichet de Clairfontaine G, Fontaine G, Funk S, Füßling M, Gabici S, Gallant YA, Giavitto G, Giunti L, Glawion D, Glicenstein JF, Grondin MH, Hahn J, Haupt M, Hermann G, Hinton JA, Hofmann W, Hoischen C, Holch TL, Holler M, Hörbe M, Horns D, Huber D, Jamrozy M, Jankowsky D, Jankowsky F, Jardin-Blicq A, Joshi V, Jung-Richardt I, Kasai E, Kastendieck MA, Katarzyński K, Katz U, Khangulyan D, Khélifi B, Klepser S, Kluźniak W, Komin N, Konno R, Kosack K, Kostunin D, Kreter M, Lamanna G, Lemière A, Lemoine-Goumard M, Lenain JP, Leuschner F, Levy C, Lohse T, Lypova I, Mackey J, Majumdar J, Malyshev D, Malyshev D, Marandon V, Marchegiani P, Marcowith A, Mares A, Martí-Devesa G, Marx R, Maurin G, Meintjes PJ, Meyer M, Mitchell A, Moderski R, Mohrmann L, Montanari A, Moore C, Morris P, Moulin E, Muller J, Murach T, Nakashima K, Nayerhoda A, de Naurois M, Ndiyavala H, Niemiec J, Oakes L, O'Brien P, Odaka H, Ohm S, Olivera-Nieto L, de Ona Wilhelmi E, Ostrowski M, Panny S, Panter M, Parsons RD, Peron G, Peyaud B, Piel Q, Pita S, Poireau V, Priyana Noel A, Prokhorov DA, Prokoph H, Pühlhofer G, Punch M, Quirrenbach A, Raab S, Rauth R, Reichherzer P, Reimer A, Reimer O, Remy Q, Renaud M, Rieger F, Rinchiuso L, Romoli C, Rowell G, Rudak B, Ruiz-Velasco E, Sahakian V, Sailer S, Salzmann H, Sanchez DA, Santangelo A, Sasaki M, Scalici M, Schäfer J, Schüssler F, Schutte HM, Schwanke U, Seglar-Arroyo M, Senniappan M, Seyffert AS, Shafi N, Shapopi JNS, Shiningayamwe K, Simoni R, Sinha A, Sol H, Specovius A, Spencer S, Spir-Jacob M, Stawarz Ł, Sun L, Steenkamp R, Stegmann C, Steinmassl S, Steppa C, Takahashi T, Tam T, Tavernier T, Taylor AM, Terrier R, Thiersen JHE, Tiziani D, Tluczykont M, Tomankova L, Tsirou M, Tuffs R, Uchiyama Y, van der Walt DJ, van Eldik C, van Rensburg C, van Soelen B, Vasileiadis G, Veh J, Venter C, Vincent P, Vink J, Völk HJ, Wadiasingh Z, Wagner SJ, Watson J, Werner F, White R, Wierzcholska A, Wong YW, Yusafzai A, Zacharias M, Zanin R, Zargaryan D, Zdziarski AA, Zech A, Zhu SJ, Zorn J, Zouari S, Żywucka N, Evans P, and Page K
Abstract: Gamma-ray bursts (GRBs), which are bright flashes of gamma rays from extragalactic sources followed by fading afterglow emission, are associated with stellar core collapse events. We report the detection of very-high-energy (VHE) gamma rays from the afterglow of GRB 190829A, between 4 and 56 hours after the trigger, using the High Energy Stereoscopic System (H.E.S.S.). The low luminosity and redshift of GRB 190829A reduce both internal and external absorption, allowing determination of its intrinsic energy spectrum. Between energies of 0.18 and 3.3 tera-electron volts, this spectrum is described by a power law with photon index of 2.07 ± 0.09, similar to the x-ray spectrum. The x-ray and VHE gamma-ray light curves also show similar decay profiles. These similar characteristics in the x-ray and gamma-ray bands challenge GRB afterglow emission scenarios., (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Published: 2021
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44. Genetic signature and treatment of pediatric high-grade glioma.

Author: Guidi M, Giunti L, Buccoliero AM, Caporalini C, Censullo ML, Galli L, Genitori L, and Sardi I
Abstract: Pediatric high-grade glioma (HGG) is a type of malignancy that carries a poor prognosis. The genetic analysis of HGGs has previously identified useful mutations, the targeting of which has improved prognosis. Thus, further research into the more common mutations, such as H3 histone variants (HIST1H3B and H3F3A) and BRAF V600E, may be useful in identifying tumors with different prognoses, as the mutations are considered to drive two distinct oncogenic programs. The present study performed a retrospective analysis of pediatric HGGs. In total, 42 cases of HGG, including 32 cases (76.1%) of anaplastic astrocytoma and 10 cases (23.8%) of glioblastoma multiforme (GBM), were assessed. The median age of the patients was 7 years (range, 0-32 years). Mutations on histone H3, in particular the K27M and G34R mutations in the distinct variants HIST1H3B and H3F3A, in addition to the presence of the BRAF V600E mutation, were analyzed in 24 patients. The H3F3A K27M mutation was identified in 7 patients (29.1%), while the HIST1H3B K27M mutation was only observed in 1 patient with GBM. In addition, 5 patients harbored a BRAF V600E mutation (21%), while the H3F3A G34R mutation was not recorded in any of the patients. The overall survival of the wild-type patients at 20 months was 68% [confidence interval (CI): 38-85%] compared with 28% (CI: 0.4-60%) in patients with the H3F3A K27M mutation. These results suggested that patients with the H3F3A K27M mutation had a worse prognosis compared with wild-type patients (P=0.0045). Moreover, 3/5 patients with the BRAF V600E mutation had HGGs that were derived from a previous low-grade glioma (LGG; P=0.001). In conclusion, these results suggested that histone H3 mutations may help predict the outcome in patients with HGG. In addition, the BRAF V600E mutation was found to be associated with an increased risk of anaplastic progression. The novel data of the present study may help better define the clinical and radiological characteristics of glioma., Competing Interests: The authors declare that they have no competing interests., (Copyright © 2020, Spandidos Publications.)
Published: 2021
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45. Leonardo spaceborne infrared payloads for Earth observation: SLSTRs for Copernicus Sentinel 3 and PRISMA hyperspectral camera for PRISMA satellite.

Author: Coppo P, Brandani F, Faraci M, Sarti F, Dami M, Chiarantini L, Ponticelli B, Giunti L, Fossati E, and Cosi M
Abstract: Leonardo has been involved in the realization of several infrared payloads for Earth observation since 1990. Among the currently in-orbit operative instruments are the two Sea and Land Surface Temperature Radiometers (SLSTRs) and PRISMA (PRecursore IperSpettrale della Missione Applicativa, meaning Hyperspectral Italian Pre-cursor of Operational mission). The SLSTRs are high-accuracy radiometers that provide sea surface temperature data continuity with respect to previous (A)ATSRs in order to serve climatology over the next 20 years, and exist within the framework of the European Space Agency Sentinel-3 mission, which is part of the Copernicus program. The PRISMA program is the first Agenzia Spaziale Italiana optical hyperspectral mission for Earth observation. It is based on a high spectral resolution spectrometer operating in the visible-short wave infrared channels optically integrated with a panchromatic camera.
Published: 2020
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46. Use of High-Dose Chemotherapy in Front-Line Therapy of Infants Aged Less Than 12 Months Treated for Aggressive Brain Tumors.

Author: Guidi M, Giunti L, Buccoliero AM, Santi M, Spacca B, De Masi S, Genitori L, and Sardi I
Abstract: Introduction: Malignant brain tumors in infants less than 12 months of age are extremely rare, and they have poor prognosis. We evaluated genetic characteristics and response rates of infants with congenital brain tumors subjected to high-dose chemotherapy and autologous stem cell transplant after gross total tumor resection. Materials and Methods: In total, 10 infants, aged less than 12 months, were enrolled in this study. The median age was 56 days (range: 1-279 days). Pathological examination demonstrated the following: four anaplastic astrocytomas, two glioblastomas, two central nervous system (CNS) embryonal tumors, not otherwise specified (NOS), and two atypical teratoid/rhabdoid tumors. Results: All patients were exposed to induction chemotherapy regimen, two high-dose chemotherapy courses, and autologous stem cell transplant after maximal surgery. At 1-3-5 years, the global overall survival (OS) was 90, 70, and 70% and the progression-free survival (PFS) was 80-60 and 60%. In all the patients, the copy number variants (CNVs) profile was analyzed using the SNP/CGH array approach. To investigate the clinical relevance of germline SMARCB1 mutation in AT/RT patients, we performed sequence analysis of the coding regions. The two patients with AT/RT were found to have germline SMARCB1 mutations. No BRAF mutations were found, and only NTRK gene fusion was present in one patient. We also have examined the association with OS and PFS and different histological subtypes of infant CNS proving that high-grade astrocytoma has better overall survival than other tumor types ( p : 0.007 and p : 0.0590). Conclusion: High-dose chemotherapy regimen represents a valid therapeutic approach for congenital brain tumors with a high rate of response. The molecular analysis has to be analyzed in all infants' brain tumor types. High-grade gliomas are characterized by a better prognosis than other histologies of infant CNS., (Copyright © 2020 Guidi, Giunti, Buccoliero, Santi, Spacca, De Masi, Genitori and Sardi.)
Published: 2020
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47. A very-high-energy component deep in the γ-ray burst afterglow.

Author: Abdalla H, Adam R, Aharonian F, Ait Benkhali F, Angüner EO, Arakawa M, Arcaro C, Armand C, Ashkar H, Backes M, Barbosa Martins V, Barnard M, Becherini Y, Berge D, Bernlöhr K, Bissaldi E, Blackwell R, Böttcher M, Boisson C, Bolmont J, Bonnefoy S, Bregeon J, Breuhaus M, Brun F, Brun P, Bryan M, Büchele M, Bulik T, Bylund T, Capasso M, Caroff S, Carosi A, Casanova S, Cerruti M, Chand T, Chandra S, Chen A, Colafrancesco S, Curyło M, Davids ID, Deil C, Devin J, deWilt P, Dirson L, Djannati-Ataï A, Dmytriiev A, Donath A, Doroshenko V, Dyks J, Egberts K, Emery G, Ernenwein JP, Eschbach S, Feijen K, Fegan S, Fiasson A, Fontaine G, Funk S, Füßling M, Gabici S, Gallant YA, Gaté F, Giavitto G, Giunti L, Glawion D, Glicenstein JF, Gottschall D, Grondin MH, Hahn J, Haupt M, Heinzelmann G, Henri G, Hermann G, Hinton JA, Hofmann W, Hoischen C, Holch TL, Holler M, Horns D, Huber D, Iwasaki H, Jamrozy M, Jankowsky D, Jankowsky F, Jardin-Blicq A, Jung-Richardt I, Kastendieck MA, Katarzyński K, Katsuragawa M, Katz U, Khangulyan D, Khélifi B, King J, Klepser S, Kluźniak W, Komin N, Kosack K, Kostunin D, Kreter M, Lamanna G, Lemière A, Lemoine-Goumard M, Lenain JP, Leser E, Levy C, Lohse T, Lypova I, Mackey J, Majumdar J, Malyshev D, Marandon V, Marcowith A, Mares A, Mariaud C, Martí-Devesa G, Marx R, Maurin G, Meintjes PJ, Mitchell AMW, Moderski R, Mohamed M, Mohrmann L, Moore C, Moulin E, Muller J, Murach T, Nakashima S, de Naurois M, Ndiyavala H, Niederwanger F, Niemiec J, Oakes L, O'Brien P, Odaka H, Ohm S, de Ona Wilhelmi E, Ostrowski M, Oya I, Panter M, Parsons RD, Perennes C, Petrucci PO, Peyaud B, Piel Q, Pita S, Poireau V, Priyana Noel A, Prokhorov DA, Prokoph H, Pühlhofer G, Punch M, Quirrenbach A, Raab S, Rauth R, Reimer A, Reimer O, Remy Q, Renaud M, Rieger F, Rinchiuso L, Romoli C, Rowell G, Rudak B, Ruiz-Velasco E, Sahakian V, Sailer S, Saito S, Sanchez DA, Santangelo A, Sasaki M, Schlickeiser R, Schüssler F, Schulz A, Schutte HM, Schwanke U, Schwemmer S, Seglar-Arroyo M, Senniappan M, Seyffert AS, Shafi N, Shiningayamwe K, Simoni R, Sinha A, Sol H, Specovius A, Spir-Jacob M, Stawarz Ł, Steenkamp R, Stegmann C, Steppa C, Takahashi T, Tavernier T, Taylor AM, Terrier R, Tiziani D, Tluczykont M, Trichard C, Tsirou M, Tsuji N, Tuffs R, Uchiyama Y, van der Walt DJ, van Eldik C, van Rensburg C, van Soelen B, Vasileiadis G, Veh J, Venter C, Vincent P, Vink J, Völk HJ, Vuillaume T, Wadiasingh Z, Wagner SJ, White R, Wierzcholska A, Yang R, Yoneda H, Zacharias M, Zanin R, Zdziarski AA, Zech A, Ziegler A, Zorn J, Żywucka N, de Palma F, Axelsson M, and Roberts OJ
Abstract: Gamma-ray bursts (GRBs) are brief flashes of γ-rays and are considered to be the most energetic explosive phenomena in the Universe 1 . The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow-produced by the interaction between the ejected matter and the circumburst medium-slows down, and a gradual decrease in brightness is observed 2 . GRBs typically emit most of their energy via γ-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments 3 . However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elusive 4 . Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow-ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and γ-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies.
Published: 2019
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48. A microRNA profile of pediatric glioblastoma: The role of NUCKS1 upregulation.

Author: Giunti L, Da Ros M, De Gregorio V, Magi A, Landini S, Mazzinghi B, Buccoliero AM, Genitori L, Giglio S, and Sardi I
Abstract: MicroRNAs (miRNAs/miRs) are a novel class of gene regulators that may be involved in tumor chemoresistance. Recently, specific miRNA expression profiles have been identified in adult glioblastoma (aGBM), but there are only limited data available on the role of miRNAs in pediatric GBM (pGBM). In the present study, the expression profile of miRNAs was examined in seven pGBMs and three human GBM cell lines (U87MG, A172 and T98G), compared with a non-tumoral pool of pediatric cerebral cortex samples by microarray analysis. A set of differentially expressed miRNAs was identified, including miR-490, miR-876-3p, miR-876-5p, miR-448 and miR-137 (downregulated), as well as miR-501-3p (upregulated). Through bioinformatics analysis, a series of target genes was predicted. In addition, similar gene expression patterns in pGBMs and cell lines was confirmed. Of note, drug resistant T98G cells had upregulated nuclear casein kinase and cyclin-dependent kinase substrate 1 ( NUCKS1 ) expression, a protein overexpressed in many tumors that serves an important role in cell proliferation and progression. On the basis of the present preliminary report, it could be intriguing to further investigate the relationship between each of the identified differentially expressed miRNAs and NUCKS1, in order to clarify their involvement in the multi-drug resistance mechanism of pGBMs.
Published: 2019
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49. Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review.

Author: Lucenteforte E, Vannacci A, Crescioli G, Lombardi N, Vagnoli L, Giunti L, Cetica V, Coniglio ML, Pugi A, Bonaiuti R, Aricò M, Giglio S, Messeri A, Barale R, Giovannelli L, Mugelli A, and Maggini V
Subjects: Adolescent, Analgesics, Opioid blood, Child, Child, Preschool, Cohort Studies, Dose-Response Relationship, Drug, Female, Genotype, Humans, Infant, Infant, Newborn, Italy, Male, Morphine blood, Pain Measurement statistics & numerical data, Polymorphism, Single Nucleotide, Analgesics, Opioid administration & dosage, Cancer Pain drug therapy, Cancer Pain genetics, Catechol O-Methyltransferase genetics, Morphine administration & dosage
Abstract: Background: Genetic polymorphisms in genes involved in pain modulation have been reported to be associated to opioid efficacy and safety in different clinical settings., Methods: The association between COMT Val158Met polymorphism (rs4680) and the inter-individual differences in the response to opioid analgesic therapy was investigated in a cohort of 87 Italian paediatric patients receiving opioids for cancer pain (STOP Pain study). Furthermore, a systematic review of the association between opioid response in cancer patients and the COMT polymorphism was performed in accordance with the Cochrane Handbook and the Prisma Statement., Results: In the 87 paediatric patients, pain intensity (total time needed to reach the lowest possible level) was significantly higher for G/G than A/G and A/A carriers (p-value = 0.042). In the 60 patients treated only with morphine, the mean of total dose to reach the same pain intensity was significantly higher for G/G than A/G and A/A carriers (p-value = 0.010). Systematic review identified five studies on adults, reporting that opioid dose (mg after 24 h of treatment from the first pain measurement) was higher for G/G compared to A/G and A/A carriers., Conclusions: Present research suggests that the A allele in COMT polymorphism could be a marker of opioid sensitivity in paediatric cancer patients (STOP Pain), as well as in adults (Systematic Review), indicating that the polymorphism impact could be not age-dependent in the cancer pain context., Trial Registration: Registration number: CRD42017057831 .
Published: 2019
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50. Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier.

Author: Da Ros M, De Gregorio V, Iorio AL, Giunti L, Guidi M, de Martino M, Genitori L, and Sardi I
Subjects: Animals, Blood-Brain Barrier drug effects, Brain Neoplasms pathology, Glioblastoma pathology, Humans, Antineoplastic Agents administration & dosage, Blood-Brain Barrier physiopathology, Brain Neoplasms drug therapy, Drug Resistance, Neoplasm, Glioblastoma drug therapy, Tumor Microenvironment drug effects
Abstract: For glioblastoma, the tumor microenvironment (TME) is pivotal to support tumor progression and therapeutic resistance. TME consists of several types of stromal, endothelial and immune cells, which are recruited by cancer stem cells (CSCs) to influence CSC phenotype and behavior. TME also promotes the establishment of specific conditions such as hypoxia and acidosis, which play a critical role in glioblastoma chemoresistance, interfering with angiogenesis, apoptosis, DNA repair, oxidative stress, immune escape, expression and activity of multi-drug resistance (MDR)-related genes. Finally, the blood brain barrier (BBB), which insulates the brain microenvironment from the blood, is strongly linked to the drug-resistant phenotype of glioblastoma, being a major physical and physiological hurdle for the delivery of chemotherapy agents into the brain. Here, we review the features of the glioblastoma microenvironment, focusing on their involvement in the phenomenon of chemoresistance; we also summarize recent advances in generating systems to modulate or bypass the BBB for drug delivery into the brain. Genetic aspects associated with glioblastoma chemoresistance and current immune-based strategies, such as checkpoint inhibitor therapy, are described too.
Published: 2018
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