Search

Floating offshore wind turbines (FOWTs) are subjected to platform motion induced by wind and wave loads. The oscillatory movement trigger vortex instabilities, modifying the wake structure, influencing the flow reaching downstream wind turbines. In this work, the wake of a FOWT is analysed by means of numerical simulations and comparison with linear stability theory. Two simplified models based on the stability of vortices are developed for all degrees of freedom of turbine motion. In our numerical simulations, the wind turbine blades are modeled as actuator lines and a spectral-element method with low dispersion and dissipation is employed to study the evolution of the perturbations. The turbine motion excites vortex instability modes predicted by the linear stability of helical vortices. The flow structures that are formed in the non-linear regime are a consequence of the growth of these modes and preserve some of the characteristics that can be explained and predicted by the linear theory. The number of vortices that interact and the growth rate of disturbances are well predicted by a simple stability model of a two-dimensional row of vortices. For all types of motion, the highest growth rate is observed when the frequency of motion is one and a half the frequency of rotation of the turbine; that induces the out-of-phase vortex pairing mechanism. For lower frequencies of motion, several vortices coalesce to form large flow structures, which cause high amplitude of oscillations in the streamwise velocities, that may increase fatigue or induce high amplitude motion on downstream turbines., 47 pages, 14 figures

The robustness of reinforced concrete (RC) structures is an important ongoing research topic in the civil engineering community. Especially in the last decades, the need for structural robustness assessment methods has become urgent, and several design methods have been proposed in codes and guidelines to mitigate the progressive collapse risk of reinforced concrete structures. The most used approaches are the Tying Force and Alternate Load Path methods. The first is typically applied as an indirect and prescriptive method where the building is considered mechanically tied together and able to enhance continuity and the resistance to progressive collapse. The second is a direct method, where the capacity of the structure to sustain the applied loads is evaluated after the loss of a load-bearing element, most effectively using advanced nonlinear structural analysis methods. In the context of the Tying Force method, the Eurocode is recognised to underestimate the tie force demands required by building structures subject to the loss of a load bearing member, which are better reflected in the USA UFC Guidelines. A new Tying Force method has been proposed by Izzuddin & Sio (2021) for the next generation of the Eurocodes, which addresses the shortcomings of the present Eurocode guidance, and provides a more comprehensive treatment than considered in the UFC code. The present paper is aimed specifically at the validation of the new Simplified Tying Force method (Izzuddin & Sio, 2021) for reinforced concrete structures, considering grillage and combined beam/slab floor systems, and considering the rotational ductility of such structures, which is explicitly considered in the new method.

Summary Gain of 20q11.21 is one of the most common recurrent genomic aberrations in human pluripotent stem cells. Although it is known that overexpression of the antiapoptotic gene Bcl-xL confers a survival advantage to the abnormal cells, their differentiation capacity has not been fully investigated. RNA sequencing of mutant and control hESC lines, and a line transgenically overexpressing Bcl-xL, shows that overexpression of Bcl-xL is sufficient to cause most transcriptional changes induced by the gain of 20q11.21. Moreover, the differentially expressed genes in mutant and Bcl-xL overexpressing lines are enriched for genes involved in TGF-β- and SMAD-mediated signaling, and neuron differentiation. Finally, we show that this altered signaling has a dramatic negative effect on neuroectodermal differentiation, while the cells maintain their ability to differentiate to mesendoderm derivatives. These findings stress the importance of thorough genetic testing of the lines before their use in research or the clinic., Highlights • Bcl-xL overexpression drives the transcriptomic profile of 20q11.21 mutant lines • 20q11.21 mutant lines downregulate CHCHD2, a known TGF-β pathway modulator • Mutant lines differentially express genes involved in TGF-β and SMAD signaling • Mutant lines show impaired ectoderm commitment due to TGF-β signaling deregulation, In this article Spits and colleagues show that Bcl-xL overexpression is the main driver of the distinct transcriptomic profile of human embryonic stem cells with a gain of 20q11.21. The cells have an abnormal TGF-β- and SMAD-mediated signaling, which impairs commitment to neuroectoderm while differentiation to the other lineages remains unaffected.

The association between serum uric acid (SUA) levels and bone mineral density (BMD) is controversial. Fat accumulation is linked to SUA and BMD, thus possibly explaining the mixed results. We found that adiposity drives part of the association between SUA and BMD in women with postmenopausal osteoporosis. Both positive and negative associations between SUA and BMD have been reported. SUA levels and BMD increase with higher body weight and other indices of adiposity; hence, the association between SUA and BMD might be a consequence of the confounding effect of adiposity. We investigated in this cross-sectional study whether the association between SUA and BMD is independent of measures of fat accumulation and other potential confounders. SUA levels, femur BMD, markers of bone metabolism, body mass index (BMI), fat mass (FM), waist circumference (WC), and abdominal visceral fat area were measured in 180 treatment-naive postmenopausal osteoporotic women (mean age 66.3 ± 8.5 years, age range 48–81 years). Women with higher SUA levels (third tertile) had significantly higher femur BMD and lower cross-linked C-terminal telopeptide of type I collagen (CTX) and bone alkaline phosphatase (bALP) levels. SUA levels were positively associated with all indices of adiposity. In multivariable analysis with femur BMD as dependent variable, the association between logarithmic (LG)-transformed SUA levels and BMD (beta = 0.42, p

Purpose After the implantation of a left ventricular assist device (LVAD), many patients continue to experience exercise intolerance . LVAD echo guided optimization (EO) determines a more favorable hemodynamic profile and could provide an improvement on functional capacity (FC). VAFRACT is a prospective randomized trial to evaluate the additional benefit of an EO approach on FC, measured by cardiopulmonary exercise test (CPET) in LVAD optimization free population. Methods Patients were randomized in a 1:1 ratio to EO (EO group) versus standard setting (CONTROL group) after at least 3 months from LVAD implant. Optimal device speed is defined as the one that allows intermittent aortic valve opening and neutral position of the interventricular septum without increasing aortic or tricuspidal regurgitation and preserving right ventricular (RV) function. The primary end point is peak oxygen uptake (VO2 peak) change at 3 months after the EO. The secondary end points are: RV function (fractional area change - FAC); hospital admissions device related; NT pro BNP levels; CPET exercise time (ET); changes in quality of life (QoL) perceived by EuroQoL Scale. At the interim analysis 15 patients have been enrolled and 10 have completed the study. Assuming α = 0.05 and an 80% power, the sample size estimation is 18 patients per group. Results No statistically significant differences have been found in basal characteristics of the two groups. Time of LVAD implantation was about 2.5 years and the most common indication to implant was Bridge to Transplant. Preliminary analysis of data concerning patients who have already completed the study shows a tendential positive impact of EO on VO2 peak, ventilatory anaerobic threshold (VAT), ET and on the QoL (Table 1). Conclusion This is the first prospective randomized trial to evaluate the additional benefit of EO on FC; final results could demonstrate that this approach could lead to improvements in exercise capacity in LVAD supported patients.

Coenzyme Q10 (CoQ10) deficiency has been associated with various clinical phenotypes, including an infantile multisystem disorder. The authors report a 33-month-old boy who presented with corticosteroid-resistant nephrotic syndrome in whom progressive encephalomyopathy later developed. CoQ10 was decreased both in muscle and in fibroblasts. Oral CoQ10 improved the neurologic picture but not the renal dysfunction.

Electrical LC resonators with superconducting coils of ≊3.5 H inductance, operating in the frequency range 250–1500 Hz with quality factors up to Q≊1.6×106 are presented here. The coil has a reduced

Summary. Drug resistance is a major limitation for the long-term efficacy of antiviral therapy with nucleos(t)ide analogues (NAs) in chronic hepatitis B (CHB). Antiviral resistance mutations may pre-exist in the overall viral population of untreated patients. We aimed to assess the prevalence of such hepatitis B virus (HBV) variants in a large cohort of NAs-naive patients with CHB and to explore possible association with viral and host variables. Serum samples from 286 NAs-naive consecutive patients with CHB were tested for serum HBV-DNA, and 255 of them having HBV-DNA > 1000 IU/mL were further analysed for drug resistance mutations by INNO-LiPA HBV DRv2/v3. NAs-naive patients analysed were mainly men (73%), Caucasians (85%), hepatitis B e Antigen (HBeAg) negative (79%) and genotype D (69%), with a mean age of 43.2 ± 13.4 years. HBV mutations associated with antiviral drug resistance were detected in 13 (5%) patients: three patients infected with HBV genotype C had the rtM204V + rtL180M mutations associated with lamivudine (LMV) resistance. Four patients had the rtI233V mutation that may reduce sensitivity to adefovir, and three patients had the rtM250L/V mutation typical of entecavir resistance. LMV compensatory mutations rtL80V and rtV173L were seen in two and one patients, respectively. No relationship was seen between presence of resistant or compensatory mutations and HBV-DNA levels, HBeAg/anti-HBe status or previous IFN therapy. These results confirm that HBV mutations, which confer resistance against currently available anti-HBV NAs, may already exist in patients who have never received the drug.

SUMMARY. Insulin resistance (IR) reduces response to pegylated-interferon (PEG-IFN)/ribavirin in chronic hepatitis C (CHC), but the mechanisms are still undefined. We examined the relationship between baseline insulin levels, the main component affecting homeostasis model of assessment ‐ insulin resistance (HOMA-IR) for assessment of IR in non-diabetic patients, and the ! acute" virological response to PEG-IFN measured 24 h after the first injection and taken as correlate of intracellular interferon signalling. In 62 patients treated with PEG-IFN/Ribavirin, serum insulin and HOMA-IR were assessed at baseline, while hepatitis C virus (HCV)-RNA was measured at baseline and 24 h, 1, 2, 4 and 12 weeks after treatment initiation. Sustained virological response was examined 24 weeks after therapy discontinuation. Mean baseline insulin was 11.52 ± 8.51 U/L and mean HOMA-IR was 2.65 ± 2.01 both being significantly higher with advanced liver fibrosis. Hepatitis C virus-RNA decay observed 24 h after the first injection of PEG-IFN was significantly lower (0.7 ± 0.8 log) in patients with HOMA ‡3 compared with those with HOMA

The pre- and protohistoric archaeological heritage is a fragile and threatened cultural resource. Its protection, its preservation and its valorization are indispensable for studying it, for interpreting it and for spreading its knowledge. Valorization is an economic and cultural development factor for society, and also, allows protecting the heritage, if done within the respect of this one. The current state of the Corsican archaeological heritage valorization is negative and worrying, unlike Sardinia which turns out to be a good model in this field. However, the situation is induced to evolve and we can draw up some tracks.

In order to compare the efficacy of nifedipine gastrointestinal therapeutic system (GITS) with diltiazem, 99 patients with chronic stable angina were studied in a parallel-group randomised trial. According to the results of the two exercise tolerance tests (ETTs) performed during the placebo run-in, patients were divided into a fixed threshold group if the variability in time to 1 mm ST-segment depression was 20%, or a variable threshold group if it was higher. Efficacy was assessed by comparing the time to 1 mm ST-depression on a bicycle ETT after 4 weeks of treatment, adjusting for the baseline value. The adjusted means were 7.44 min for nifedipine GITS and 7.68 min for diltiazem; the difference was -0.24 min, with a lower 90% confidence limit of -0.90, which is within the stated interval for equivalence. The same result was confirmed by the 'intention-to-treat' analysis, and comparable results were obtained both in fixed and in variable threshold groups. The incidence of side effects was 12% with nifedipine GITS and 8.2% with diltiazem. Nifedipine GITS and diltiazem were found to be equally effective in increasing exercise tolerance in chronic stable angina patients.

A twelve-years-old boy developed fever, pharyngitis and acute migrant polyarthralgia. An increasing ASO titre was observed, so that rheumatic fever was firstly diagnosed. Finally splenomegaly and positive IgG and IgM against Epstein Barr virus led to the diagnosis of acute EBV infection with polyarthritis. EBV infection should be considered into the differential diagnosis of migrant polyarthritis.

The aim of the present study is to establish the role of ultrasound examination (US) in the diagnosis of acute pancreatitis and its ability in differentiating mild or edematous acute pancreatitis (EAP) from severe or necrotizing acute pancreatitis (NAP) in order to indicate further diagnostic procedures and appropriate therapy. Forty patients with clinical suspect of acute pancreatitis were examined with US. All of them were followed-up clinically and with laboratory tests. Nineteen patients underwent a CT examination with contrast media and one without. In 28 cases US diagnosed acute pancreatitis in agreement with clinical and laboratory data. US identified 19 patients with EAP and 9 with NAP. CT, performed in 20 cases on the basis of clinical and US findings, confirmed US diagnosis in 19 cases while in 1 patient CT identified a NAP instead of the EAP suggested by US. According to our results, US is an easy-to-perform and accurate method for the diagnosis of acute pancreatitis and effective in differentiating EAP from NAP; it is also useful in suggesting further diagnostic procedures such as contrast-enhanced CT required in patients with NAP to assess the extension of peripancreatic fluid-collections and possible complications.

We re-evaluated the cases of 436 children with minor head injury admitted in the paediatric department of Modena University Hospital in the years 1991-1995 in order to revise diagnostic and therapeutic protocols. The external lesions, the presence of loss consciousness, vomiting, vegetative reactions, late complications, skull X ray, TC scan and EEG were considered. Signs and symptoms at admission have been faced with instrumental findings and eventual late complications to evaluate the prognostic significance. External lesions and vomiting did not correspond to TC scan and EEG positivity or significant sequelae. A more close connection to these parameters was found when an history of immediate loss of consciousness after trauma, or presence of vegetative reactions. Skull X ray appeared useless both to judge the seriousness of the lesion and to formulate a prognosis. EEG appeared a sensible tool to evaluate the gravity of the trauma and its late consequences. TC has confirmed to be the unique instrument able to solve any diagnostic or prognostic doubt. When symptoms suggest a bad prognosis, diagnostic procedures should be limited to TC and EEG. By our point of view, patients that at admission have a normal neurological examination at the Glasgow Coma Scale, no significant symptoms and signs, an history of a minor impact dynamic and no signs of child abuse, can be discharged from the emergency department; in this case parents should be instructed how to do an observation at home in order to evaluate eventual complications.

Frey syndrome (gustatory sweating, auricolotemporal syndrome) is a complication of parotidectomy, probably caused by misdirection of regenerating fibers in the auricolotemporal nerve. The authors review the pathophysiology and describe the treatment used in this entity.

Between January and December 1992 an epidemiological survey on the risk factors for cardiovascular disease in eighteen-year old boys during call-up has been performed in Verona. The study involved 3426 subjects: 100% of the boys coming from the metropolitan area and 65% of those coming from the non-metropolitan areas. A family history of hypertension was found in 9.54% of the subjects and a family history of myocardial infarction or sudden death was found in 4.54% of the subjects. 0.18% of the population reported diabetes and 2% hypertension. Prevalence of smoke addiction was 39.1% and in this group 17.54% smokedor = 20 cigarettes/day. Prevalence of smoke addiction was significantly greater in the boys having one or both smoking parents (p0.001), in working people in respect to students (p0.001), in boys from metropolitan in respect to those from non-metropolitan areas (p = 0.033), and among those not practising sport activity (p0.001). Mean systolic and diastolic blood pressure were 130.16 +/- 13/74.48 +/- 9 mm Hg and 90th percentile was 149/87 mm Hg. Systolic and diastolic blood pressure were significantly lower in boys from metropolitan in respect to those from non-metropolitan areas and in smokers in respect to non smokers. A body mass indexor = 30 was found in 3.04% of the subjects, the body mass index being directly related to systolic and diastolic blood pressure (p0.001). Total cholesterol performed on a voluntary basis from capillary blood samples by Reflotron System was determined in 80.06% of the subjects. Mean blood cholesterol was 139.1 +/- 28 mg/dL and 90th percentile's value was 182 mg/dL. Mean blood cholesterol was significantly lower in non-metropolitan in respect to metropolitan areas (p = 0.033). 44.48% of the subjects had one or more risk factors, 5.22% had two risk factors and 0.67% three or more risk factors for cardiovascular disease. This study shows that 1) in this population of young people a significant part is exposed to one or more cardiovascular risk factors; 2) social and environmental factors affect, sometimes deeply, the prevalence of cardiovascular risk factors; 3) The visit for call-up appears to be important in the setting-up of a strategy of primary prevention for cardiovascular disease.

Short-term outcome after coronary angioplasty is mainly determined by restenosis, while long-term outcome is determined by new events due to incomplete revascularization, by atherosclerosis progression and by late-restenosis. The aim of this study is to assess if correctly treated coronary risk factors are predictors of poor prognosis after coronary angioplasty. Two-hundred and twenty six patients (209 males, 17 females, mean age 56 +/- 9 years) with successful coronary angioplasty were treated for coronary risk factors. New events (death, myocardial infarction, repeat angioplasty, bypass surgery) were recorded. Ischemia was evaluated by serial exercise tests. The mean follow-up was 31 +/- 12 months. Survival was 99.5% at 1 year and 97.4% after 5 years; "event free survival" was 84.6% at 1 year and 65.9% after 5 years; "ischemia free survival" was 84.6% at 1 year and 44.8% after 5 years. "Ischemia free survival" was higher in patients with single coronary angioplasty and in patients with infarct-related vessel angioplasty. Smoke addiction, diabetes, hypercholesterolemia and hypertension were not significantly correlated with "ischemia free survival". Smokers and diabetics had a trend towards a less favorable 5 year outcome, but without statistical differences. In conclusion, this study shows that correctly treated coronary risk factors do not worsen prognosis after coronary angioplasty.

Twenty patients (12 males, 8 females, mean age 51 +/- 10 years) with mild to moderate arterial hypertension were treated with nitrendipine (mean daily dose 17 mg) during a 6 month period. Patients were evaluated with blood measurement and with 24-hour ambulatory blood pressure monitoring. In 16 patients who completed the study, systolic and diastolic blood pressure decreased of 13-15% and 18-20% respectively after at least 1 month of therapy. Mean 24-hour blood pressure was reduced of 9.7% (p0.01) at the end of the third month and of 13.9% (p0.01) at the end of the sixth month. Both systolic and diastolic 24-hour blood pressure were significantly reduced. Nitrendipine was active on day time and night time pressure. Only 1 patient had edema of the legs. Heart rate was not increased by the drug. Total cholesterol and LDL cholesterol were reduced.

Patients with ischemic heart disease are often affected by a mixed hyperlipoproteinemia, where a hypercholesterolemia of various severity is accompanied by slight or moderate hypertriglyceridemia (type IIb dyslipidemia). Current epidemiologic evidence suggests that hypertriglyceridemia has not to be disregarded, particularly in certain subgroups of patients. We evaluated the effect of the association of simvastatin 10 mg/day [an hydroxymethyl-glutaryl-CoA (HMG-CoA) reductase inhibitor] and omega-3 polyunsaturated fatty acids (n3-PUFA) in comparison with simvastatin 10 mg/day alone. The subjects undergoing the study were affected by coronary artery disease and showed hypercholesterolemia (LDL-cholesterol160 mg/dl) and moderate hypertriglyceridemia (serum triglycerides 200-400 mg/dl) after 2 months of moderate dietary therapy for hyperlipidemia (Step 1 of the National Cholesterol Education Program [NCEP]). Thirty-nine patients were randomized to have 1 of 2 scheduled treatments. At the same time the patients underwent severe dietary therapy for hyperlipidemia (Step 2 of the NCEP). After 3 months of treatment, total-cholesterol, LDL-cholesterol, and triglycerides were significantly lower than basal values in both groups (p0.05). Total-cholesterol, LDL-cholesterol, and triglycerides were lower in the group treated with n3-PUFA and simvastatin compared to simvastatin alone. However, only for triglycerides was the difference significant (-39.99% in patients treated with n3-PUFA and simvastatin versus -25.65% in patients treated with simvastatin alone, particularly in the first group of 35.85%; p0.05). With regard to HDL-cholesterol, the differences between the basal values and the 2 groups of treatments were non significant. Remarkable side effects were not observed in the 2 groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Because of the existing relation between myocardial blood flow and systolic function, various noninvasive techniques, capable of assessing regional and global left ventricular function, especially two-dimensional echocardiography, have been used in patients with chest pain, ECG evidence of myocardial ischemia and/or reduced coronary flow reserve and angiographically detected normal coronary vessels. The results, however, have been contradictory, while only few of them have reported stress-induced regional or global left ventricular dysfunction combined with ST-segment depression and/or angina. The reason for such discrepancy could be due to a diffuse but patchy distribution of myocardial ischemia, or to a non-ischemic origin of the clinical and instrumental features of this syndrome, relying on the effect of algogenic mediators, as suggested from recent metabolic studies. Even if the most recent theories agree on the functional involvement of the small coronary vessels, many points on microvascular angina remain confused. An agreement on the nosological classification of this syndrome would be welcome, given the high technological cost required for the study of coronary microcirculation.

When HCVpp lacking the HVR were used (or when SRB1 was inhibited by BLT-4) serum enhancement was lost, particularly in HIV coinfected patients. In HIV patients, neutralization was positively and independently related to CD4 count (p < 0.01) and to antiretroviral therapy (p < 0.001). Selective pressure on HVR was higher in immunocompetent subjects and was related to the neutralization observed with serum immunoglobulin fraction. Conclusion: The sera of patients coinfected by HIV or liver transplanted are poorly neutralizing and facilitate the entry of HCVpp mainly through HVR and SRB1. Our findings are the first to show that low neutralization/high facilitation is related to the immune status and could be involved in the severity of HCV in immunocompromized subjects.

In July 1987 a prehospital emergency medical service (EMS) was activated in Verona (Italy) and a broad educational campaign was introduced. Prehospital care is delivered by emergency physicians and/or qualified nursing staff, who travel by ambulance or helicopter and have radio contact with the hospital alarm centre. During a 1-year period before the activation of the EMS, 476 patients with acute myocardial infarction (AMI) were admitted to the coronary care unit (CCU) of Verona, with a median delay time of 4 hours. In the period between July 1990 and June 1991, 412 patients were admitted, with a median delay time of 3 hours. Age, gender, previous AMI and infarct location were not related to delay time. In the second period, 34% patients used the EMS, while 66% used their own transport. In patients who used the EMS, median delay time was 2 hours (1 hour and 20 min shorter, p0.01, than in patients who did not). The time between symptoms onset and reaching the decision that medical care should be sought (1 hour and 18 min) was the longest component of the total delay time. The time from EMS call to hospital arrival was 25 min and the time which elapsed in the Emergency Department before reaching the CCU was 15 min. In these patients, decision time and Emergency Department time were significantly shorter (p0.01) than in patients who did not use the EMS. We conclude that the EMS is effective in reducing delay time in patients with AMI.

A case of lithiasis due to indwelling double J ureteral stent is described. Pathogenesis and possibilities of prevention are discussed.

With the aim of investigating the functional result of the coronary angioplasty (PTCA) and verifying the predictive value of the exercise test for detecting restenosis, 165 patients who underwent successful PTCA were evaluated through exercise stress tests performed 10, 75 and 165 days after PTCA and through coronary angiography performed 5 to 6 months after PTCA. The percentage of negative tests and the rate-pressure product (RPP) increased significantly with respect to the tests performed before PTCA, both in patients with single-vessel and those with multivessel disease. Maximal ST segment depression and ST/HR were significantly reduced only in patients with complete revascularization. The percentage of positive tests 10 days after PTCA was lower in patients with single-vessel than in those with multivessel disease (2.5% versus 10.8%) and, of the latter, in patients with complete rather than incomplete revascularization (0% versus 13.5%). In patients with complete revascularization, the mean exercise time rose significantly (703 s versus 538 s). The percentage of positive tests increased progressively with time, in accordance with probable increasing restenosis. In comparison with the results of angiography, sensitivity of the exercise stress test proved to be poor (59%), especially in patients with single-vessel disease (45%), while the specificity was very high (98%). The predictive value of a negative test was 77% in patients with multi-vessel and 87% in patients with single-vessel disease. The predictive value of a positive test was over 90% in both groups of patients.

A low noise high frequency r.f. SQUID is used for detecting the current flowing in a superconducting inductance coupled to a capacitive resonant displacement-voltage transducer. The SQUID output power spectrum for the whole system shows a noise performance only a factor two worse than in the uncoupled configuration. An upper limit for the predicted SQUID negative resistance has been found.

AURIGA is a resonant gravitational wave detector under development at the INFN laboratories of Legnaro, Italy. Its main liquid Helium cryostat houses vibration isolation stages, the dilution refrigerator, the 2.3 tons cylindrical antenna and the resonant displacement transducer, in a design derived from NAUTILUS, the other INFN ultracryogenic antenna. The expected working temperature of the antenna, transducer and inner vibration isolation stage is about 50 mK. We implemented additional features to increase the long term reliability of AURIGA, particularly in the dilution refrigerator. The design provides also for a separate cryostat with short thermal cycle, which will house the signal amplification stage. This allows independent temperature control of the cryogenic electronics and helps its optimization and maintenance.

In a random trial on 40 patients undergoing extraction of the third lower molar 0.125 mg of triazolam were administered sublingually to 20 patients and placebo (lactulose solution 66.7%) to 20 patients. The sedative and amnesic effect rapidly appeared after triazolam while the anxiolytic effect was less pronounced. The recovery of psychomotor functions measured by standard psychomotor tests occurred rapidly and all patients were discharged after about 120 min from the end of the surgery. The judgment of the surgeon was positive as far as the anxiolytic and relaxing effects of triazolam was concerned. The patients treated with triazolam moreover appreciated the sedation induced by the drug. No cardiocirculatory complication was observed and the patients showed a considerable stability from the circulatory stand point. The results show that triazolam may represent a safe alternative to the use of other anxiolytic and sedative drugs in the minor surgery of the oral cavity.

This study has been carried out with the aim of assessing the incidence and other features of Infective Endocarditis in the region Veneto (Italy) in the years 1975-84, with particular regard to the patients admitted to the hospitals in Verona. Of the 692 patients admitted in hospitals of Veneto, 629 were resident in the region (an incidence equal to 1.6/100,000 inhabitants per year). The age range was from 8 to 72 (55 +/- 9). All social classes were affected, although retired, disabled and unemployed subjects were in the majority. The average stay in hospitals was 27.6 days. In 7.6% of the cases surgical therapy was required; the over-all mortality rate was 10%. Of the 80 patients admitted to the hospitals in Verona, 79% were suffering from pre-existing cardiopathy (40% rheumatic heart disease, 25% valvular prosthesis, 7.5% congenital heart disease, 5% prolapsing mitral valve, 1.2% obstructive hypertrophic cardiomyopathy); 54% of the cases had been exposed to bacteriological infections in the preceding months: bronchopulmonary, oropharyngeal, genitourinary or gall bladder infections processes or oral surgery or heart surgery or drug addiction. Only in 19% of these cases a correct antibiotic prophylaxis had been carried out. The responsible germ was identified in 50 patients (67% of the cases in which blood cultures had been performed): Streptococcus in 22%, Staphylococcus in 20%, Gram-negative in 12%, Corynebacterium in 4%, polymicrobial associations in 9% of the cases. These data stress the need for an improvement in antibiotic drug regimen (both in prophylaxis and treatment) and the diffusion of norms of hygiene aimed to the reduction of skin and mucous sources of bacteremia and interpersonal transmission of infections disease.

A superconducting electrical LC resonator has been developed operating at 2 KHz and 4.2 K with a quality factor Q of 105 and a coil inductance of 1.6 H. The experimental set-up has been accurately designed to reduce stray losses as much as possible. As detector of the oscillation has been used a commercial r.f. SQUID which permits very high Q measurements without adding losses. Applications to a resonant ultracryogenic gravitational wave antenna and future development are discussed.

Quantitative ultrasound (QUS) techniques based on the parameterization of the backscatter coefficient (BSC) generally assume that the tissue under consideration is homogeneous and isotropic. However, tissues such as flowing blood aggregates and biceps muscles exhibit anisotropy in the BSC and/or attenuation coefficient. Recent works have proposed the measurement of anisotropic QUS parameters by using the reference phantom method when performing conventional imaging modalities, i.e. beamsteering or plane wave, with linear array transducers. One limitation remains the maximal angle to which the BSC can be measured, which is determined by the probe steering capability that depends on element directivity (array design) and crosstalk (transducer technology). The aim of this work is to compare the performance of a Capacitive Micromachined Ultrasonic Transducer (CMUT) and a piezoelectric probe in measuring backscatter anisotropy. Ultrasonic experiments were conducted on two comparable probes, i.e. the commercial piezoelectric probe LA435 (ESAOTE, Florence, Italy) (fc=12.5 MHz, 80% FBW, pitch=0.2 mm), and the HF3 CMUT prototype probe (fc=12.5 MHz, 100% FBW, pitch=0.2 mm), using the ULA-OP open ultrasonic system. In vitro measurements of the BSC using the focused beam steering imaging strategy were performed on an anisotropic tissue-mimicking phantom at different insonification angles ranging from 0° to 20°. The results show how the limited steering capabilities of linear probes could affect the measurement of BSC, and in general the anisotropic QUS parameters, bringing into discussion their consideration in the development of experimental strategies for the assessment of tissue anisotropy.

Femicide, defined as the killing of females by males because they are females, is be-coming recognized worldwide as an im-portant ongoing manifestation of gender inequality. Actual or imminent separation, abuser’s access to firearms, prior threats with a weapon, prior threats to kill the victim, a stepchild in the household, prob-lematic alcohol and illicit drug use, as well as mental health problems, are associated with a substantially higher risk of femi-cide. Little is known about the number of orphaned children who have instantane-ously lost both parents. Sparse attention has been focused on children whose moth-er was murdered: these are difficult cases for child psychiatry teams. Decisions about protection could be made by judges, the police, social workers or officers that at-tend victims, on the basis of empirical data and not merely by using intuitive criteria.