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Your search keyword '"L. F. Courtney"' showing total 9 results
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9 results on '"L. F. Courtney"'

1. Asymmetric synthesis of a key ring A synthon for 1α-hydroxy-19-nor vitamin D

Author

Peter Michael Wovkulich, Meinolf Lange, Milan R. Uskokovic, and L. F. Courtney

Subjects
Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Synthon, Enantioselective synthesis, Substrate (chemistry), Regioselectivity, Ring (chemistry), Biochemistry, Ene reaction
Abstract

A diasteroselective carbonyl ene reaction on a substrate obtained from a regioselective propiolate ene reaction is described for the synthesis of 19-nor A-ring synthon 3.

Published
1998
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2. ChemInform Abstract: Synthesis of Tetrahydrolipstatin

Author

Andrew D. Batcho, Charles M. Cook, L. F. Courtney, Milan R. Uskokovic, P. C. Tang, Naresh Chadha, and Peter M. Wovkulich

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Hydroboration, Cyclopentadiene, chemistry, Stereochemistry, Enantioselective synthesis, Regioselectivity, Organic chemistry, Alcohol, General Medicine, Lactone
Abstract

An asymmetric synthesis of tetrahydrolipstatin (4) is described. Application of our previously described in situ cyclopentadiene alkylation-asymmetric hydroboration protocol provided the key chiral alcohol 9. In the course of this work, the presence of a free hydroxyl group was found to exert a strong directing effect on the regioselectivity of a Baeyer-Villiger reaction (16→17). Subsequent transformations of lactone 17 produced tetrahydrolipstatin (4)

Published
2010
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3. ChemInform Abstract: Asymmetric Synthesis of a Key Ring A Synthon for 1α-Hydroxy-19-nor Vitamin D

Author

Peter Michael Wovkulich, L. F. Courtney, Meinolf Lange, and Milan R. Uskokovic

Subjects
Chemistry, Stereochemistry, Synthon, Enantioselective synthesis, Substrate (chemistry), Regioselectivity, General Medicine, Ring (chemistry), Ene reaction
Abstract

A diasteroselective carbonyl ene reaction on a substrate obtained from a regioselective propiolate ene reaction is described for the synthesis of 19-nor A-ring synthon 3.

Published
2010
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4. Synthesis of tetrahydrolipstatin

Author

P. C. Tang, Naresh Chadha, Andrew D. Batcho, L. F. Courtney, Charles M. Cook, Milan R. Uskokovic, and Peter M. Wovkulich

Subjects
chemistry.chemical_classification, Hydroboration, chemistry.chemical_compound, Cyclopentadiene, chemistry, Stereochemistry, Organic Chemistry, Enantioselective synthesis, Regioselectivity, Alcohol, Lactone
Abstract

An asymmetric synthesis of tetrahydrolipstatin (4) is described. Application of our previously described in situ cyclopentadiene alkylation-asymmetric hydroboration protocol provided the key chiral alcohol 9. In the course of this work, the presence of a free hydroxyl group was found to exert a strong directing effect on the regioselectivity of a Baeyer-Villiger reaction (16→17). Subsequent transformations of lactone 17 produced tetrahydrolipstatin (4)

Published
1991
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9. Stereochemistry of acetic acid formation from 5-methyltetrahydrofolate by Clostridium thermoaceticum

Author

L. D. Zydowsky, Helmut Simon, L. F. Courtney, K. Lee, H. G. Floss, Stephen J. Benkovic, and Herbert Lebertz

Subjects
biology, Stereochemistry, Clostridiales, General Chemistry, Metabolism, biology.organism_classification, Biochemistry, Catalysis, chemistry.chemical_compound, Acetic acid, Colloid and Surface Chemistry, chemistry, Carbon dioxide, biology.protein, Organic chemistry, Clostridiaceae, Bacteria, Carbon monoxide, Carbon monoxide dehydrogenase
Published
1987
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