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2 results on '"L. Doregatti"'

1. Piperacillin versus cefotetan as single-dose prophylaxis in abdominal hysterectomy: a prospective, randomized, multicenter study

Author

V. Meregalli, F. Quaglia, Rodolfo Milani, L. Negri, L. Archetti, F. Rampinelli, L. Doregatti, E. Demaria, R. Conturso, G. Alegente, Gc. Zanella, F. De Lalla, F. Pollini, S. Scalambrino, A. Tramarin, Pg. Tassi, A. Lojacono, R Nicolin, Delalla, F, Tassi, P, Conturso, R, Archetti, L, Zanella, G, Meregalli, V, Milani, R, Quaglia, F, Nicolin, R, Scalambrino, S, Alegente, G, Doregatti, L, Pollini, F, Demaria, E, Negri, L, Rampinelli, F, Lojacono, A, and Tramarin, A

Subjects
Adult, medicine.medical_specialty, medicine.drug_class, Cefotetan, medicine.medical_treatment, Premedication, Antibiotics, Uterus, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Hysterectomy, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Surgical Wound Infection, Pharmacology (medical), Prospective Studies, Prophylaxi, Pharmacology, Piperacillin, Chemotherapy, Abdominal hysterectomy, business.industry, Middle Aged, medicine.disease, Surgery, Infectious Diseases, medicine.anatomical_structure, Oncology, Anesthesia, Bacteremia, Female, business, medicine.drug, Subcutaneous tissue
Abstract

ive hundred and sixty-six women, consecutively admitted to nine different hospitals for elective abdominal hysterectomy, were randomized to receive a single 2 g i.v. dose of either cefotetan or piperacillin at induction of anesthesia. Five patients were excluded and 561 (287 given cefotetan and 274 given piperacillin) could be evaluated. In 10 patients (5 for each drug) the concentrations of either cefotetan or piperacillin in serum and subcutaneous tissue at the beginning and at the end of surgery andin uterus, salpinx and ovary samples, were microbiologically assessed. Adverse events to prophylactic drugs were never observed. No significant differences could be found between cefotetan and piperacilin groups for any of the considered infectious complications (bacteremia, wound or vaginal cuff infection, pelvic cellulitis and febrile morbidity) nor for the pooled data (cefotetan group: 4.9%, piperacillin group: 5.8%, p:NS). As for the concentrations of prophylactic drugs, serum levels throughout surgery were found to be adequate

Published
1993

2. Piperacillin versus cefotetan as single-dose prophylaxis in abdominal hysterectomy: a prospective, randomized, multicenter study.

Author

de Lalla F, Scalambrino S, Tassi PG, Alegente G, Conturso R, Doregatti L, Archetti L, Pollini F, Zanella GC, and Demaria E

Subjects
Adult, Female, Humans, Middle Aged, Prospective Studies, Surgical Wound Infection prevention & control, Cefotetan therapeutic use, Hysterectomy methods, Piperacillin therapeutic use, Premedication
Abstract

Five hundred and sixty-six women, consecutively admitted to nine different hospitals for elective abdominal hysterectomy, were randomized to receive a single 2 g i.v. dose of either cefotetan or piperacillin at induction of anesthesia. Five patients were excluded and 561 (287 given cefotetan and 274 given piperacillin) could be evaluated. In 10 patients (5 for each drug) the concentrations of either cefotetan or piperacillin in serum and subcutaneous tissue at the beginning and at the end of surgery and in uterus, salpinx and ovary samples, were microbiologically assessed. No significant differences could be found between cefotetan and piperacillin groups for any of the considered infectious complications (bacteremia, wound or vaginal cuff infection, pelvic cellulitis and febrile morbidity) nor for the pooled data (cefotetan group: 4.9%, piperacillin group: 5.8%, p:NS). As for the concentrations of prophylactic drugs, serum levels throughout surgery were found to be adequate.

Published
1993
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