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We study the spectral and temporal properties of the black hole X-ray transient binary MAXI J1820+070 during the 2018 outburst with Insight-HXMT observations. The outburst of MAXI J1820+070 can be divided into three intervals. For the two intervals of the outburst, we find that low-energy (below 140 keV) photons lag high-energy (140–170 keV) ones, while in the decay of the outburst, high-energy photons lag low-energy photons, both with a time-scale of the order of days. Based on these results, the canonical hysteresis effect of the ‘q’ shape in the hardness–intensity diagram can be reformed into a roughly linear shape by taking into account the lag corrections between different energy bands. Time analysis shows that the high-frequency break of hard X-rays, derived from the power-density spectrum of the first interval of the outburst, is in general larger and more variable than that of soft X-rays. The spectral fitting shows that the coverage fraction of the hard X-rays drops sharply at the beginning of the outburst to about 0.5, and then increases slightly. The coverage fraction drops to roughly zero once the source steps into soft state and increases gradually to unity when the source returns to low–hard state. We discuss the possible overall evolution scenario of corona hinted from these discoveries.

We studied the 2018 outburst of the black hole transient H 1743 − 322 with a series of Insight-HXMT, NICER, and NuSTAR observations, covering the 1–120 keV band. With our broad-band X-ray spectral modelling, we confirm that the source remained in the low/hard state throughout the month-long outburst, although it became marginally softer at peak flux. We detected Type-C quasi-periodic oscillations (QPOs) and followed the evolution of their properties. The QPO frequency increased from ∼0.1 to ∼0.4 Hz during the rising phase of the outburst and decreased again in the decline. Continuum X-ray flux, power-law photon index, QPO frequency, and QPO root-mean-square amplitude were positively correlated. The QPO amplitude was slightly higher in the soft X-ray band (typical values of 12–16 per cent, compared with 8–10 per cent in the hard band). Our spectral-timing results shed light on the initial rising phase in the low/hard state, which has rarely been monitored with such high cadence, time resolution, and broad-band coverage. Combining spectral and timing properties, we find that ‘failed’ (hard state only) and ‘successful’ outbursts follow the same initial evolutionary track, although the former class of outburst never reaches the threshold for a transition to softer (thermally dominated) accretion regimes.

We investigate systematically four outbursts of black hole system GX 339-4 observed by the Rossi X-ray Timing Explorer (RXTE) in both spectral and timing domains and find that these outbursts have some common properties although they experience different 'q' tracks in the hardness-intensity diagram (HID). While the spectral indices are around 1.5 in low hard state (LHS), 2.4 in soft intermediate state (SIMS) and high soft state (HSS), the spectral parameters of thermal, non-thermal and reflection components vary significantly in transitions from LHS to HIMS. Also the quasi periodic oscillation (QPO) shows a peculiar behavior during the state transition between LHS and HIMS: the RMS drop of type C fundamental QPO is accompanied with showing-up of the second harmonic. Interestingly, the QPO RMS is found to have a similar linear relationship with the non-thermal fraction of emission in different outbursts. These findings provide more clues to our understanding the outburst of the black hole X-ray binary system., 13 papes, 12 figures

GRO J1008-57, as a Be/X-ray transient pulsar, is considered to have the highest magnetic field in known neutron star X-ray binary systems. Observational data of the X-ray outbursts in GRO J1008-57 from 2017 to 2020 were collected by the Insight-HXMT satellite. In this work, the spin period of the neutron star in GRO J1008-57 was determined to be about 93.28 seconds in August 2017, 93.22 seconds in February 2018, 93.25 seconds in June 2019 and 93.14 seconds in June 2020. GRO J1008-57 evolved in the spin-up process with a mean rate of − ( 2.10 ± 0.05 ) × 10−4 s/d from 2009 – 2018, and turned into a spin down process with a rate of ( 6.7 ± 0.6 ) × 10−5 s/d from Feb 2018 to June 2019. During the type II outburst of 2020, GRO J1008-57 had the spin-up torque again. During the torque reversals, the pulse profiles and continuum X-ray spectra did not change significantly, and the cyclotron resonant scattering feature around 80 keV was only detected during the outbursts in 2017 and 2020. Based on the observed mean spin-up rate, we estimated the inner accretion disk radius in GRO J1008-57 (about 1 - 2 times of the Alfven radius) by comparing different accretion torque models of magnetic neutron stars. During the spin-down process, the magnetic torque should dominate over the matter accreting inflow torque, and we constrained the surface dipole magnetic field B ≥ 6 × 10 12 G for the neutron star in GRO J1008-57, which is consistent with the magnetic field strength obtained by cyclotron line centroid energy.

We report on the Insight-HXMT observations of the new black hole X-ray binary MAXI J1820+070 during its 2018 outburst. Detailed spectral analysis via the continuum fitting method shows an evolution of the inferred spin during its high soft sate. Moreover, the hardness ratio, the non-thermal luminosity and the reflection fraction also undergo an evolution, exactly coincident to the period when the inferred spin transition takes place. The unphysical evolution of the spin is attributed to the evolution of the inner disc, which is caused by the collapse of a hot corona due to condensation mechanism or may be related to the deceleration of a jet-like corona. The studies of the inner disc radius and the relation between the disc luminosity and the inner disc radius suggest that, only at a particular epoch, did the inner edge of the disc reach the innermost stable circular orbit and the spin measurement is reliable. We then constrain the spin of MAXI J1820+070 to be a*=0.2^{+0.2}_{-0.3}. Such a slowly spinning black hole possessing a strong jet suggests that its jet activity is driven mainly by the accretion disc rather than by the black hole spin., Comment: 14 pages, 13 figures, 5 tables, accepted for publication in MNRAS

Fast radio bursts (FRBs) are short pulses observed in radio band from cosmological distances. One class of models invoke soft gamma-ray repeaters (SGRs), or magnetars, as the sources of FRBs. Some radio pulses have been observed from some magnetars, however, no FRB-like events had been detected in association any magnetar burst, including one giant flare. Recently, a pair of FRB-like bursts (FRB 200428 hereafter) separated by milliseconds (ms) were detected from the general direction of the Galactic magnetar SGR J1935+2154. Here we report the detection of a non-thermal X-ray burst in the 1-250 keV energy band with the Insight-HXMT satellite, which we identify as emitted from SGR J1935+2154. The burst showed two hard peaks with a separation of 34 ms, broadly consistent with that of the two bursts in FRB 200428. The delay time between the double radio and X-ray peaks is about 8.57 s, fully consistent with the dispersion delay of FRB 200428. We thus identify the non-thermal X-ray burst is associated with FRB 200428 whose high energy counterpart is the two hard peaks in X-ray. Our results suggest that the non-thermal X-ray burst and FRB 200428 share the same physical origin in an explosive event from SGR J1935+2154., 24 pages, 9 figures, 6 tables; initial submission to a journal on May 9th, 2020. Significant changes include updated localization and detailed spectral evolution of the X-ray burst, and better determination of the two narrow X-ray peaks corresponding to the two radio pulses. Conclusions are strengthened. Nature Astronomy online on Feb. 18, 2021

A black hole X-ray binary produces hard X-ray radiation from its corona and disk when the accreting matter heats up. During an outburst, the disk and corona co-evolves with each other. However, such an evolution is still unclear in both its geometry and dynamics. Here we report the unusual decrease of the reflection fraction in MAXI J1820+070, which is the ratio of the coronal intensity illuminating the disk to the coronal intensity reaching the observer, as the corona is observed to contrast during the decay phase. We postulate a jet-like corona model, in which the corona can be understood as a standing shock where the material flowing through. In this dynamical scenario, the decrease of the reflection fraction is a signature of the corona's bulk velocity. Our findings suggest that as the corona is observed to get closer to the black hole, the coronal material might be outflowing faster., 11 pages, 5 figures; published in Nature Communications; An artist's impression of Figure 5 is updated here, and the animation is available at http://youbei.work/research/

Recently, the system parameters of Cygnus X-1, i.e., the black hole mass M, the orbital inclination i and the source distance D, have been updated. As the input constraints of the continuum-fitting method, it is necessary to refine the spin with these new parameters. The Hard X-ray Modulation Telescope (HXMT, also named Insight) was successfully launched on June 15th, 2017 in China. In this work, we analyzed spectra obtained by the Insight-HXMT during 2017-2018 and re-estimated the spin via the continuum-fitting method. We first re-estimated the spin using old parameters and found the dimensionless spin parameter to be a ⁎ > 0.934 (3σ), which is consistent with previous measurements both from the continuum-fitting and iron-line fitting methods ( Gou et al. 2011 , Gou et al. 2014 ; Fabian et al. 2012 , Walton et al. 2016 , Tomsick et al. 2018 ). Then, when the new parameters were applied, we obtained an increased spin: a ⁎ > 0.967 (3σ), which is also consistent with the recent measurement (Zhao et al. 2020, submitted to ApJ) and also confirms an extreme Kerr black hole lying in this system.

A new black hole X-ray binary (BHXRB) MAXI J1535-571 was discovered by MAXI during its outburst in 2017. Using observations taken by the first Chinese X-ray satellite, the Hard X-ray Modulation Telescope (dubbed as Insight-HXMT), we perform a joint spectral analysis (2-150 keV) in both energy and time domains. The energy spectra provide the essential input for probing the intrinsic Quasi-Periodic Oscillation (QPO) fractional rms spectra (FRS). Our results show that during the intermediate state, the energy spectra are in general consistent with those reported by Swift/XRT and NuSTAR. However, the QPO FRS become harder and the FRS residuals may suggest the presence of either an additional power-law component in the energy spectrum or a turn-over in the intrinsic QPO FRS at high energies.

We study the 2018 outburst of Aql X-1 via the monitor of all sky X-ray image (MAXI) data. We show that the outburst starting in February 2018 is a member of short-low class in the frame of outburst duration and the peak count rate although the outburst morphology is slightly different from the other fast-rise-exponential-decay (FRED) type outbursts with a milder rising stage. We study the partial accretion in the weak propeller stage of Aql X-1 via the MAXI data of the 2018 outburst. We report on the spectral analysis of 3 observations of Aquila X-1 obtained by Insight – hard X-ray modulation telescope (Insight-HXMT) during the late decay stage of the 2018 outburst. We discuss that the data taken by Insight-HXMT is just after the transition to the weak propeller stage. Our analysis shows the necessity of a comptonization component to take into account the existence of an electron cloud resulting photons partly up-scattered.

We present a detailed timing study of the brightest persistent X-ray source Sco X-1 using the data collected by the Hard X-ray Modulation Telescope ( I n s i g h t -HXMT) from July 2017 to August 2018. A complete Z-track hardness-intensity diagram (HID) is obtained. The normal branch oscillations (NBOs) at ∼ 6 Hz in the lower part of the normal branch (NB) and the flare branch oscillations (FBOs) at ∼ 16 Hz in the beginning part of the flaring branch (FB) are found in observations with the Low Energy X-ray Telescope (LE) and the Medium Energy X-ray Telescope (ME) of I n s i g h t -HXMT, while the horizontal branch oscillations (HBOs) at ∼ 40 Hz and the kilohertz quasi-periodic oscillations (kHz QPOs) at ∼ 800 Hz are found simultaneously above 20 keV for the first time on the horizontal branch (HB) by the High Energy X-ray Telescope (HE) and ME. We find that for all types of the observed QPOs, the centroid frequencies are independent of energy, while the root mean square (rms) increases with energy; the centroid frequencies of both the HBOs and kHz QPOs increase along the Z-track from the top to the bottom of the HB; and the NBOs show soft phase lags increasing with energy. A continuous QPO transition from the FB to NB in ∼ 200 s are also detected. Our results indicate that the non-thermal emission is the origin of all types of QPOs, the innermost region of the accretion disk is non-thermal in nature, and the corona is nonhomogeneous geometrically.

Recently investigators pay more attention to the relationship between obesity and bronchial asthma (asthma).Obesity is increasingly recognized as a possible risk factor for childhood asthma, and 70% of patients with difficult-to-treat asthma are overweight or obese. In recent years, ketogenic diet, as one of the natural therapies, has been shown to have positive effects on weight loss process; and recent studies showed that ketogenic diet reduced airway inflammation in asthma. This review summarized the mechanisms of associations between obesity and asthma, and described the potential mechanisms of ketogenic diet affecting obese asthma, such as controlling body weight, reducing inflammatory response, regulating intestinal flora and modifying epigenetics, to provide new ideas for the prevention and treatment of obesity asthma.肥胖和支气管哮喘（以下简称哮喘）之间的相关性日益受到关注，70%难治性哮喘患者超重或肥胖，肥胖已成为哮喘的重要危险因素。近年来，生酮饮食作为自然疗法之一，被证实有治疗肥胖症的作用，并且也有研究指出生酮饮食可降低哮喘气道炎症。本文总结了肥胖与哮喘的关联机制，阐述了生酮饮食影响肥胖型哮喘的潜在机制，如控制体重，减轻炎症反应，调节肠道菌群和修饰表观遗传，为肥胖型哮喘的防治提供新的思路。.

We present a spectral study of the black hole candidate MAXI J1348-630 during its 2019 outburst, based on monitoring observations with Insight-HXMT and Swift. Throughout the outburst, the spectra are well fitted with power-law plus disk-blackbody components. In the soft-intermediate and soft states, we observed the canonical relation L ~ T_in^4 between disk luminosity L and peak colour temperature T_in, with a constant inner radius R_in (traditionally identified with the innermost stable circular orbit). At other stages of the outburst cycle, the behaviour is more unusual, inconsistent with the canonical outburst evolution of black hole transients. In particular, during the hard rise, the apparent inner radius is smaller than in the soft state (and increasing), and the peak colour temperature is higher (and decreasing). This anomalous behaviour is found even when we model the spectra with self-consistent Comptonization models, which take into account the up-scattering of photons from the disk component into the power-law component. To explain both those anomalous trends at the same time, we suggest that the hardening factor for the inner disk emission was larger than the canonical value of ~1.7 at the beginning of the outburst. A more physical trend of radii and temperature evolution requires a hardening factor evolving from ~3.5 at the beginning of the hard state to ~1.7 in the hard intermediate state. This could be evidence that the inner disk was in the process of condensing from the hot, optically thin medium and had not yet reached a sufficiently high optical depth for its emission spectrum to be described by the standard optically-thick disk solution., 20 pages, 10 figures, 4 tables, accepted by ApJ

We execute a detailed spectral-timing study of Cygnus X-1 in the low/hard, intermediate and high/soft states with the Hard X-ray Modulation Telescope observations. The broad band energy spectra fit well with the "truncated disk model" with the inner boundary of the accretion disk stays within $\sim$10 \textit R$_{\rm g}$ and moves inward as the source softens. Through studying of PDS, rms and Fourier-frequency component resolved spectroscopy, we find that the X-ray variations are generated in two different regions for each state. We discover that the major role that contributes to the X-ray variation is the hot corona rather than the accretion disk. We suggest a scenario with different corona geometry for each state based on the truncated disk geometry in which the corona wraps up the disk to form a sandwich geometry in the low/hard state, and then gradually moves away from the disk in direction that is perpendicular to the disk until forming a jet-like geometry in the high/soft state., 13 pages, 12 figures, and 3 tables, accepted for publication in ApJ

We report results on the timing analysis of the 2020 giant outburst of 1A 0535+262, using broadband data from Insight-HXMT. The analysis of the pulse profile evolution from the subcritical-luminosity to the supercritical-luminosity regime is presented for the first time. We found that the observed pulse profile exhibits a complex dependence on both energy and luminosity. A dip structure at the energy of the cyclotron resonant scattering features is found for the first time in the pulse fraction–energy relation of 1A 0535+262, when the outburst evolves in a luminosity range from 4.8 × 1037 to 1.0 × 1038 erg s−1. The observed structure is luminosity dependent and appears around the source critical luminosity (∼6.7 × 1037 erg s−1).

We report the energy-resolved broadband timing analysis of the black hole X-ray transient MAXI J1631-479 during its 2019 outburst from February 11 to April 9, using data from the Insight-Hard X-ray Modulation Telescope (Insight-HXMT), which caught the source from its hard intermediate state to the soft state. Thanks to the large effective area of Insight-HXMT at high energies, we are able to present the energy dependence of fast variability up to ~100 keV. Type-C quasi-periodic oscillations (QPOs) with frequency varying between 4.9 Hz and 6.5 Hz are observed in the 1-100 keV energy band. While the QPO fractional rms increases with photon energy from 1 keV to ~10 keV and remains more or less constant from ~10 keV to ~100 keV, the rms of the flat-top noise first increases from 1 keV to ~8 keV then drops to less than 0.1% above ~30 keV. We suggest that the disappearance of the broadband variability above 30 keV could be caused by the non-thermal acceleration in the Comptonizing plasma. At the same time, the QPOs could be produced by the precession of either a small-scale jet or a hot inner flow model., To be published in The Astrophysical Journal

The evidences for the influence of thermonuclear (type-I) X-ray bursts upon the surrounding environments in neutron star low-mass X-ray binaries (LMXB) were detected previously via spectral and timing analyses. Benefitting from a broad energy coverage of Insight-HXMT, we analyze one photospheric radius expansion (PRE) burst, and find an emission excess at soft X-rays. Our spectral analysis shows that, such an excess is not likely relevant to the disk reflection induced by the burst emission and can be attributed to an enhanced pre-burst/persistent emission. We find that the burst and enhanced persistent emissions sum up to exceed Eddington luminosity by ∼ 40 percentages. We speculate that the enhanced emission is from a region beyond the PRE radius, or through the Comptonization of the corona.

In this paper, we presented a detailed timing analysis of a prominent outburst of 4U 0115+63 detected by \textit{Insight}-HXMT in 2017 August. The spin period of the neutron star was determined to be $3.61398\pm 0.00002$ s at MJD 57978. We measured the period variability and extract the orbital elements of the binary system. The angle of periastron evolved with a rate of $0.048\pm0.003$ $yr^{-1}$. The light curves are folded to sketch the pulse profiles in different energy ranges. A multi-peak structure in 1-10 keV is clearly illustrated. We introduced wavelet analysis into our data analysis procedures to study QPO signals and perform a detailed wavelet analysis in many different energy ranges. Through the wavelet spectra, we report the discovery of a QPO at the frequency $\sim 10$ mHz. In addition, the X-ray light curves showed multiple QPOs in the period of $\sim 16-32 $ s and $\sim 67- 200 $ s. We found that the $\sim100$ s QPO was significant in most of the observations and energies. There exist positive relations between X-ray luminosity and their Q-factors and S-factors, while the QPO periods have no correlation with X-ray luminosity. In wavelet phase maps, we found that the pulse phase of $\sim 67- 200 $ s QPO drifting frequently while the $\sim 16-32 $ s QPO scarcely drifting. The dissipation of oscillations from high energy to low energy was also observed. These features of QPOs in 4U 0115+63 provide new challenge to our understanding of their physical origins., 14 pages, 9 figures, and 6 tables. This work has been submitted to MNRAS after the referee's report

We report on a detailed spectral analysis of the transient X-ray pulsar 1A~0535+262, which underwent the brightest giant outburst ever recorded for this source from November to December 2020 with a peak luminosity of $1.2$ $\times10^{38}\ \rm erg\ s^{-1}$. Thanks to the unprecedented energy coverage and high cadence observations provided by Insight-HXMT, we were able to find for the first time evidence for a transition of the accretion regime. At high luminosity, above the critical luminosity $6.7\times10^{37}$ erg s$^{-1}$, the cyclotron absorption line energy anti-correlates with luminosity. Below the critical luminosity, a positive correlation is observed. The 1A~0535+262 becomes, therefore, the second source after V~0332+53, which clearly shows an anti-correlation above and transition between correlation and anti-correlation around the critical luminosity. The evolution of both the observed CRSF line energy and broadband X-ray continuum spectrum throughout the outburst exhibits significant differences during the rising and fading phases: that is, for a similar luminosity the spectral parameters take different values which results in hysteresis patterns for several spectral parameters including the cyclotron line energy. We argue that, similarly to V~0332+53, these changes might be related to different geometry of the emission region in rising and declining parts of the outburst, probably due to changes in the accretion disk structure and its interaction with the magnetosphere of the neutron star.

Based on Insight-HXMT data, we report on the pulse fraction evolution during the 2017–2018 outburst of the newly discovered first Galactic ultraluminous X-ray (ULX) source Swift J0243.6+6124. The pulse fractions of 19 observation pairs selected in the rising and fading phases with similar luminosity are investigated. The results show a general trend of the pulse fraction increasing with luminosity and energy at supercritical luminosity. However, the relative strength of the pulsation between each pair evolves strongly with luminosity. The pulse fraction in the rising phase is larger at luminosity below 7.71 × 1038 erg s−1, but smaller at above. A transition luminosity is found to be energy independent. Such a phenomenon is first confirmed by Insight-HXMT observations and we speculate that it may have relation with the radiation-pressure-dominated accretion disc.

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846–031 during its outburst in 2019 with the observations of Insight-HXMT, NICER and MAXI. This outburst can be classified roughly into four different states. Type-C quasi-periodic oscillations (QPOs) observed by NICER (about 0.1–6 Hz) and Insight-HXMT (about 0.7–8 Hz) are also reported in this work. Meanwhile, we study various physical quantities related to QPO frequency. The QPO rms–frequency relationship in the energy band 1–10 keV indicates that there is a turning pointing in frequency around 2 Hz, which is similar to that of GRS 1915+105. A possible hypothesis for the relationship above may be related to the inclination of the source, which may require a high inclination to explain it. The relationships between QPO frequency and QPO rms, hardness, total fractional rms and count rate have also been found in other transient sources, which can indicate that the origin of type–C QPOs is non-thermal.

Low-frequency quasi-periodic oscillations (LFQPOs) are commonly found in black hole X-ray binaries, and their origin is still under debate. The properties of LFQPOs at high energies (above 30 keV) are closely related to the nature of the accretion flow in the innermost regions, and thus play a crucial role in critically testing various theoretical models. The Hard X-ray Modulation Telescope (Insight-HXMT) is capable of detecting emissions above 30 keV, and is therefore an ideal instrument to do so. Here we report the discovery of LFQPOs above 200 keV in the new black hole MAXI J1820+070 in the X-ray hard state, which allows us to understand the behaviours of LFQPOs at hundreds of kiloelectronvolts. The phase lag of the LFQPO is constant around zero below 30 keV, and becomes a soft lag (that is, the high-energy photons arrive first) above 30 keV. The soft lag gradually increases with energy and reaches ~0.9s in the 150-200 keV band. The detection at energies above 200 keV, the large soft lag and the energy-related behaviors of the LFQPO pose a great challenge for most currently existing models, but suggest that the LFQPO probably originates from the precession of a small-scale jet., 36 pages, 12 figures, 3 tables; published in Nature Astronomy

We study the evolution of the temporal properties of MAXI 1820+070 during the 2018 outburst in its hard state from MJD 58190 to 58289 with Insight-HXMT in a broad energy band 1-150 keV. We find different behaviors of the hardness ratio, the fractional rms and time lag before and after MJD 58257, suggesting a transition occurred at around this point. The observed time lags between the soft photons in the 1-5 keV band and the hard photons in higher energy bands, up to 150 keV, are frequency-dependent: the time lags in the low-frequency range, 2-10 mHz, are both soft and hard lags with a timescale of dozens of seconds but without a clear trend along the outburst; the time lags in the high-frequency range, 1-10 Hz, are only hard lags with a timescale of tens of milliseconds; first increase until around MJD 58257 and decrease after this date. The high-frequency time lags are significantly correlated to the photon index derived from the fit to the quasi-simultaneous NICER spectrum in the 1-10 keV band. This result is qualitatively consistent with a model in which the high-frequency time lags are produced by Comptonization in a jet., Comment: Accepted for publication in ApJ

As China's first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band (1-250 keV) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 MeV. It was designed to perform pointing, scanning and gamma-ray burst (GRB) observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed. Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results., 29 pages, 40 figures, 6 tables, to appear in Sci. China-Phys. Mech. Astron. arXiv admin note: text overlap with arXiv:1910.04434

We report on our analysis of the 2019 outburst of the X-ray accreting pulsar 4U 1901+03 observed with Insight-HXMT and NICER. Both spectra and pulse profiles evolve significantly in the decaying phase of the outburst. Dozens of flares are observed throughout the outburst. They are more frequent and brighter at the outburst peak. We find that the flares, which have a duration from tens to hundreds of seconds, are generally brighter than the persistent emission by a factor of $\sim$ 1.5. The pulse profile shape during the flares can be significantly different than that of the persistent emission. In particular, a phase shift is clearly observed in many cases. We interpret these findings as direct evidence of changes of the pulsed beam pattern, due to transitions between the sub- and super-critical accretion regimes on a short time scale. We also observe that at comparable luminosities the flares' pulse profiles are rather similar to those of the persistent emission. This indicates that the accretion on the polar cap of the neutron star is mainly determined by the luminosity, i.e., the mass accretion rate., 11 pages, 8 figures, accepted for publication in MNRAS

No robust detection of prompt electromagnetic counterparts to fast radio bursts (FRBs) has yet been obtained, in spite of several multi-wavelength searches carried out so far. Specifically, X/gamma-ray counterparts are predicted by some models. We planned on searching for prompt gamma-ray counterparts in the Insight-Hard X-ray Modulation Telescope (Insight-HXMT) data, taking advantage of the unique combination of large effective area in the keV-MeV energy range and of sub-ms time resolution. We selected 39 FRBs that were promptly visible from the High-Energy (HE) instrument aboard Insight-HXMT. After calculating the expected arrival times at the location of the spacecraft, we searched for a significant excess in both individual and cumulative time profiles over a wide range of time resolutions, from several seconds down to sub-ms scales. Using the dispersion measures in excess of the Galactic terms, we estimated the upper limits on the redshifts. No convincing signal was found and for each FRB we constrained the gamma-ray isotropic-equivalent luminosity and the released energy as a function of emission timescale. For the nearest FRB source, the periodic repeater FRB180916.J0158+65, we find $L_{\gamma,iso}, Comment: 15 pages, 3 figures, 6 tables, accepted by A&A

We report on the observation of the accreting pulsar GRO J1008-57 performed by Insight-HXMT at the peak of the source's 2017 outburst. Pulsations are detected with a spin period of 93.283(1) s. The pulse profile shows double peaks at soft X-rays, and only one peak above 20 keV. The spectrum is well described by the phenomenological models of X-ray pulsars. A cyclotron resonant scattering feature is detected with very high statistical significance at a centroid energy of $E_{\rm cyc}=90.32_{-0.28}^{+0.32}$ keV, for the reference continuum and line models, HIGHECUT and GABS respectively. Detection is very robust with respect to different continuum models. The line energy is significantly higher than what suggested from previous observations, which provided very marginal evidence for the line. This establishes a new record for the centroid energy of a fundamental cyclotron resonant scattering feature observed in accreting pulsars. We also discuss the accretion regime of the source during the Insight-HXMT observation., Comment: 8 pages, 3 figures, accepted for publication in ApJL

A link between magnetars and fast radio burst (FRB) sources has finally been established. In this context, one of the open issues is whether/which sources of extra galactic FRBs exhibit X/gamma-ray outbursts and whether it is correlated with radio activity. We aim to constrain possible X/gamma-ray burst activity from one of the nearest extragalactic FRB sources currently known over a broad energy range, by looking for bursts over a range of timescales and energies that are compatible with being powerful flares from extragalactic magnetars. We followed up the as-yet nearest extragalactic FRB source at a mere 149 Mpc distance, the periodic repeater FRB180916.J0158+65, during the active phase on February 4-7, 2020, with the Insight-Hard X-ray Modulation Telescope (HXMT). Taking advantage of the combination of broad band, large effective area, and several independent detectors available, we searched for bursts over a set of timescales from 1 ms to 1.024 s with a sensitive algorithm, that had previously been characterised and optimised. Moreover, through simulations we studied the sensitivity of our technique in the released energy-duration phase space for a set of synthetic flares and assuming different energy spectra. We constrain the possible occurrence of flares in the 1-100 keV energy band to E, 10 pages, 3 figures, accepted by A&A

We investigate the absorption and emission features in observations of GX 301-2 detected with Insight-HXMT/LE in 2017-2019. At different orbital phases, we found prominent Fe Kalpha, Kbeta and Ni Kalpha lines, as well as Compton shoulders and Fe K-shell absorption edges. These features are due to the X-ray reprocessing caused by the interaction between the radiation from the source and surrounding accretion material. According to the ratio of iron lines Kalpha and Kbeta, we infer the accretion material is in a low ionisation state. We find an orbital-dependent local absorption column density, which has a large value and strong variability around the periastron. We explain its variability as a result of inhomogeneities of the accretion environment and/or instabilities of accretion processes. In addition, the variable local column density is correlated with the equivalent width of the iron Kalpha lines throughout the orbit, which suggests that the accretion material near the neutron star is spherically distributed., Comment: 10 pages, 5 figures, 2 tables, accepted for publication in MNRAS

Glitches correspond to sudden jumps of rotation frequency ($\nu$) and its derivative ($\dot{\nu}$) of pulsars, the origin of which remains not well understood yet, partly because the jump processes of most glitches are not well time-resolved. There are three large glitches of the Crab pulsar, detected in 1989, 1996 and 2017, which were found to have delayed spin-up processes before the normal recovery processes. Here we report two additional glitches of the Crab pulsar occurred in 2004 and 2011 for which we discovered delayed spin up processes, and present refined parameters of the largest glitch occurred in 2017. The initial rising time of the glitch is determined as $, Comment: 25 pages, 8 figures

The hard X-ray transient source Swift J1845.7-0037 was discovered in 2012 by Swift/BAT. However, at that time no dedicated observations of the source were performed. On Oct 2019 the source became active again, and X-ray pulsations with a period of ~199s were detected with Swift/XRT. This triggered follow-up observations with NuSTAR. Here we report on the timing and spectral analysis of the source properties using NuSTAR and Swift/XRT. The main goal was to confirm pulsations and search for possible cyclotron lines in the broadband spectrum of the source to probe its magnetic field. Despite highly significant pulsations with period of 207.379(2) were detected, no evidence for a cyclotron line was found in the spectrum of the source. We therefore discuss the strength of the magnetic field based on the source flux and the detection of the transition to the "cold-disc" accretion regime during the 2012 outburst. Our conclusion is that, most likely, the source is a highly magnetized neutron star with B 1e13G at a large distance of d~10 kpc. The latter one consistent with the non-detection of a cyclotron line in the NuSTAR energy band., submitted to A&A

We report on analysis of observations of the bright transient X-ray pulsar \src obtained during its 2017-2018 giant outburst with Insight-HXMT, \emph{NuSTAR}, and \textit{Swift} observatories. We focus on the discovery of a sharp state transition of the timing and spectral properties of the source at super-Eddington accretion rates, which we associate with the transition of the accretion disk to a radiation pressure dominated (RPD) state, the first ever directly observed for magnetized neutron star. This transition occurs at slightly higher luminosity compared to already reported transition of the source from sub- to super-critical accretion regime associate with onset of an accretion column. We argue that this scenario can only be realized for comparatively weakly magnetized neutron star, not dissimilar to other ultra-luminous X-ray pulsars (ULPs), which accrete at similar rates. Further evidence for this conclusion is provided by the non-detection of the transition to the propeller state in quiescence which strongly implies compact magnetosphere and thus rules out magnetar-like fields., Submitted to MNRAS

We present a study of timing properties of the accreting pulsar 2S 1417-624 observed during its 2018 outburst, based on Swift/BAT, Fermi/GBM, Insight-HXMT and NICER observations. We report a dramatic change of the pulse profiles with luminosity. The morphology of the profile in the range 0.2-10.0keV switches from double to triple peaks at $\sim2.5$ $\rm \times 10^{37}{\it D}_{10}^2\ erg\ s^{-1}$ and from triple to quadruple peaks at $\sim7$ $\rm \times 10^{37}{\it D}_{10}^2\ erg\ s^{-1}$. The profile at high energies (25-100keV) shows significant evolutions as well. We explain this phenomenon according to existing theoretical models. We argue that the first change is related to the transition from the sub to the super-critical accretion regime, while the second to the transition of the accretion disc from the gas-dominated to the radiation pressure-dominated state. Considering the spin-up as well due to the accretion torque, this interpretation allows to estimate the magnetic field self-consistently at $\sim7\times 10^{12}$G., 7 pages, 4 figures, 1 tables, accepted for publication in MNRAS

LS 5039 is a well-known $\gamma$-ray binary system which consists of an unknown compact object and a massive companion O star. It shows rather stable emissions at high energies over years and hence serves as an ideal laboratory to investigate the emission mechanism for such peculiar systems which emit prominent $\gamma$-rays. To this end, we take the orbital phase resolved energy spectrum as observed by \fermi over 10 years. We divide the orbit into four orbital phases, each with an orbital phase range of 0.25, centered at 0.00, 0.25, 0.50 and 0.75 respectively, where the phase 0.0 is the periastron and phase 0.5 is the apastron. The phases around 0.25 and 0.75 are symmetric and hence are supposed to have identical local acceleration environment. The spectral analysis shows that, the \fermi spectra are largely different from these two symmetric orbital phases: the emission from orbital phase 0.25 turns out to be significantly stronger than that from 0.75. This result does not fit a scenario that $\gamma$-rays are Doppler boosted emission from bow shock tails if LS 5039 has a shock configuration similar to PSR B1259-63, and indicates that the inverse Compton scatterings between the shock accelerated plasma and the stellar particle environment is the underline procedure. We also find that the previous report for a disappearance of the orbital modulation at 3--20 GeV is due to the similar spectral turn-over energies of the different orbital phases. The spectral properties of periastron and apastron regions are addressed in the context of the measurements in phase regions around 0.25 and 0.75., Comment: 7 pages, 3 figures. Published in RAA

We present the analysis of the brightest flare that was recorded in the \emph{Insight}-HMXT data set, in a broad energy range (2$-$200 keV) from the microquasar GRS~1915+105 during an unusual low-luminosity state. This flare was detected by \emph{Insight}-HXMT among a series of flares during 2 June 2019 UTC 16:37:06 to 20:11:36, with a 2-200 keV luminosity of 3.4$-$7.27$\times10^{38}$ erg s$^{-1}$. Basing on the broad-band spectral analysis, we find that the flare spectrum shows different behaviors during bright and faint epochs. The spectrum of the flare can be fitted with a model dominated by a power-law component. Additional components show up in the bright epoch with a hard tail and in the faint epoch with an absorption line $\sim$ 6.78 keV. The reflection component of the latter is consistent with an inner disk radius $\sim$ 5 times larger than that of the former. These results on the giant flare during the "unusual" low-luminosity state of GRS~1915+105 may suggest that the source experiences a possible fast transition from a jet-dominated state to a wind-dominated state. We speculate that the evolving accretion disk and the large-scale magnetic field may play important roles in this peculiar huge flare.

PSR B1259-63 is a $\gamma$-ray emitting high mass X-ray binary system, in which the compact object is a millisecond pulsar. The system has an orbital period of 1236.7 d and shows peculiar $\gamma$-ray flares when the neutron star moves out of the stellar disk of the companion star. The $\gamma$-ray flare events were firstly discovered by using Fermi-LAT around the 2010 periastron passage, which was repeated for the 2014 and 2017 periastron passages. We analyze the Fermi-LAT data for all the three periastron passages and found that in each flare the energy spectrum can be represented well by a simple power law. The $\gamma$-ray light curves show that in 2010 and 2014 after each periastron there are two main flares, but in 2017 there are four flares including one precursor about 10 d after the periastron passage. The first main flares in 2010 and 2014 are located at around 35 d after the periastron passage, and the main flare in 2014 is delayed by roughly 1.7 d with respect to that in 2010. In the 2017 flare, the source shows a precursor about 10 d after the periastron passage, but the following two flares become weaker and lag behind those in 2010 by roughly 5 d. The strongest flares in 2017 occurred 58 d and 70 d after the periastron passage. These results challenge the previous models., Comment: 8 pages, 3 figures, accepted for publication in RAA

Corona cooling was detected previously from stacking a series of short type-I bursts occurred during the low/had state of atoll outburst. Type-I bursts are hence regarded as sharp probe to our better understanding on the basic property of the corona. The launch of the first Chinese X-ray satellite Insight-HXMT has large detection area at hard X-rays which provide almost unique chance to move further in this research field. We report the first detection of the corona cooling by Insight-HXMT from single short type-I burst showing up during {\bf flare} of 4U 1636-536. This type-I X-ray burst has a duration of $\sim$13 seconds and hard X-ray shortage is detected with significance 6.2~$\sigma$ in 40-70 keV. A cross-correlation analysis between the lightcurves of soft and hard X-ray band, shows that the corona shortage lag the burst emission by 1.6 $\pm$1.2~s. These results are consistent with those derived previously from stacking a large amount of bursts detected by RXTE/PCA within a series of {\bf flares} of 4U 1636-536. Moreover, the broad bandwidth of Insight-HXMT allows as well for the first time to infer the burst influence upon the continuum spectrum via performing the spectral fitting of the burst, which ends up with the finding that hard X-ray shortage appears at around 40 keV in the continuum spectrum. These results suggest that the evolution of the corona along with the outburst{\bf /flare} of NS XRB may be traced via looking into a series of embedded type-I bursts by using Insight-HXMT., Comment: published in 2018, ApJL,864, L30

To investigate the effects of Processing on antioxidation of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati.The oxygen free radicals generation system and mouse liver homogenate lipid peroxidation in vitro were used.The processed products of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati could scavenge superoxide radical (O2-.) generated through hypoxanthine-oxidase system and (.OH) generated through Fenton action, and inhibit lipid peroxidation induced by hydroxyl radical generation system, respectively. There existed significant differences among the different processed products.After Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati were processed, their effects became weaker.

To investigate the effects of different processing products of Cortex Phellodendri on scavenging oxygen free radicals and anti-lipid peroxidation.The oxygen free radicals generation system and mouse liver homogenate lipid peroxidation in vitro were used.The aqueous and 80% alcohol extracts of raw, stir-fried, stir-fried with salt, stir-fried with yellow alcohol products of Cortex Phellodendri could scavenge superoxide radical(O2-.) generated through hypoxanthine-oxidase system and(.OH) generated through Fenton action, and inhibit lipid peroxidation induced by hydroxyl radical generation system, respectively. But the carbonized product has no effect. There are differences among these processed products.80% alcohol extract of stir-fried with yellow alcohol products of Cortex Phellodendri was more intense.

To study the inhibition of liquiritigenin (1) and isoliquiritigenin (2) isolated from Sinofranchetia chinensis on rat monoamine oxidase A and B (MAO A and B).Rat brain mitochondrial fraction, prepared by differential centrifugation, was utilized as a source of MAO activity. MAO activity was determined radiochemically with [14C]5-hydroxytryptamine (5-HT) and [14C]beta-phenylethylamine (beta-PEA) used as MAO A or B specific radiolabled substrates, respectively. The Ki and KI values were obtained from Lineweaver-Burk plot using linear regression analysis.Liquiritigenin and isoliquiritigenin were found to be inhibitory against both MAO A and B in a dose-dependent manner. IC50 (95% of confidence limits) of liquiritigenin and isoliquiritigenin were 32 (26-36) and 13.9 (12.8-15.6) mumol/L for the inhibition of MAO A, and 104.6 (89.0-118.9) and 47.2 (39.5-54.5) mumol/L for that of MAO B, respectively. Lineweaver-Burk transformation of the MAO A inhibition data indicated that the inhibition was non-competitive for both liquiritigenin and isoliquiritigenin whereas their inhibition of MAO B was of mixed type. Regarding MAO A inhibition, the Ki values of liquiritigenin and isoliquiritigenin were 31.5 mumol/L and 14.3 mumol/L, respectively. As to the inhibition of MAO B, the Ki and KI data for liquiritigenin were 164.7 and 15.2 mumol/L, and those for isoliquiritigenin were 62.2 and 9.3 mumol/L, respectively.Liquiritigenin and isoliquiritigen inhibited the activity of MAO A and B in rat brain mitochondria, and the latter was more active than the former.

As a kind of anti-inflammatory protein fractionated and purified from the larva of parasa sinica, CCP (ip) has a significant anti-inflammatory effect on ear odema induced by croton oil in mice. Its ID50 is 1.6mg/kg, but a dose of 2.5mg/kg can also significantly inhibit the rat ankle odema induced by carrageenan and egg white.

It has been shown that StE can significantly shorten PT, TT, KPTT and RT of experimental animals and has an antiheparin function in the body. Meanwhile, it can significantly shorten ELT and strengthen FA. Its hemostatic action is accomplished through promoting coagulation and inhibiting fibrinolysis. 3P test and EG test were negative, it is thus impossible for a large dosage of StE to lead to DIC.

It has been shown that the fatsoluble extract SeE from carbonized Schizonepeta tenuifolia has an obvious hemostatic action. In a given range of dose there is a significant linear correlation between the logarithms of its doses and the reciprocal of the bleeding and coagulating times in mice. Obvious hemostatic action was observed after mice had been administered in ip and po respectively for 0.5h and 1h. The hemostatic time of the former was 6h and the latter 12h. The LD50 of StE in po was 2.652 +/- 0.286 g/kg, while in ip 1.945 4/- 0.207 g/kg.