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151 results on '"L. CUCCURULLO"'

11. A case of centrocytic and centroblastic nodular lymphoma with low malignity and exclusively gingival localisation

Author

FEMIANO, Felice, LAINO, Gregorio, C. BUONAIUTO, L. CUCCURULLO, Femiano, Felice, Laino, Gregorio, C., Buonaiuto, and L., Cuccurullo

Subjects
Lymphoma, non-Hodgkin, diagnosi, hemic and lymphatic diseases, Lymphoma, non-Hodgkin, pathology, Lymphoma, non-Hodgkin, therapy
Abstract

The authors report a case of centrocytic and centroblastic lymphoma with low malignity and a primary and exclusive localisation in a 43 years-old woman. The centrocytic and centroblastic lymphoma is the most frequent variety of non-Hodgkin lymphoma and represents a lymphoproliferative pathology affecting lymphatic structures: lymph nodes, spleen and bone marrow. Cases with an extranodal localisation are not infrequently documented. Histological analysis reveals the structure of the neoplasm in follicular-like nodular formations represented by a dual cell population identifiable in small-sized cell elements (centrocytes) coexisting with voluminous, rounded cells with chromatin positioned behind the nuclear membrane and with a pronounced nucleolus (centroblasts). The authors report a case of centrocytic and centroblastic lymphoma with low malignity and a primary and exclusive localisation in a 43 years-old woman. The centrocytic and centroblastic lymphoma is the most frequent variety of non-Hodgkin lymphoma and represents a lymphoproliferative pathology affecting lymphatic structures: lymph nodes, spleen and bone marrow. Cases with an extranodal localisation are not infrequently documented. Histological analysis reveals the structure of the neoplasm in follicular-like nodular formations represented by a dual cell population identifiable in small-sized cell elements (centrocytes) coexisting with voluminous, rounded cells with chromatin positioned behind the nuclear membrane and with a pronounced nucleolus (centroblasts).

Published
2001

13. An ultrastructural study of the histogenesis of haemangioblastoma

Author

L, Cuccurullo, M E, Prudente, S, Maffia, and M, Accardo

Subjects
Adult, Male, Cell Differentiation, Middle Aged, Lipid Metabolism, Hemangioblastoma, Mesoderm, Humans, Female, Endothelium, Vascular, Stromal Cells, Cerebellar Neoplasms, Pericytes, Aged
Abstract

Seven cases of cerebellar haemangioblastoma, not associated with von Hippel-Lindau disease (sporadic haemangioblastomas), were studied by light and electron transmission microscopy. Morphological features that might provide information about the histogenesis of the tumour were examined. The ultrastructural data indicate both the common ancestry of the different cytotypes that make up the tumour, and the mesenchymal origin of the elements present, which were also documented by their capacity to synthesise lipid droplets in the cytoplasm (a process of lipidization similar to that of pre-adipocytes).

Published
2009

15. ULTRASTRUCTURAL PATHOLOGY OF PEDIATRIC MYOCARDIUM IN ACUTE ISCHEMIA: BIOPTIC STUDY BEFORE AND AFTER TREATMENT WITH CARDIOPLEGIC SOLUTION

Author

C Vosa, M. Accardo, S Esposito, L. Agozzino, L. Cuccurullo, F. Blasi, Cuccurullo, L., Accardo, M., Agozzino, L., Blasi, F., Esposito, S., Vosa, Carlo, Accardo, Marina, Agozzino, Lucio, Vosa, C., Cuccurullo, L, Blasi, F, and Esposito, S

Subjects
Heart Defects, Congenital, pediatric heart surgery, medicine.medical_specialty, Myocardial Ischemia, Ischemia, Celsior cardioplegic solution, Vascular permeability, Ultrastructural Pathology, Pathology and Forensic Medicine, law.invention, Acute ischemia, Capillary Permeability, Necrosis, Microscopy, Electron, Transmission, Structural Biology, law, Internal medicine, Edema, medicine, Cardiopulmonary bypass, Humans, Myocytes, Cardiac, Cardioplegic Solutions, St. Thomas solution, Cardiopulmonary Bypass, business.industry, Myocardium, Infant, Heart, medicine.disease, Interstitial edema, Child, Preschool, Anesthesia, Cardiology, medicine.symptom, business, After treatment
Abstract

Protecting the myocardium from the risk of acute ischemia during heart surgery is still an unsolved problem; the problem is even more open and more pressing in pediatric heart surgery. To meet this greater risk it is advisable to use a cardioplegic solution with a composition that is better suited to the particular morphofunctional conditions of the myocardium in the child, i.e., a solution offering greater protection. To this purpose the authors experimented with Celsior cardioplegic solution during heart surgery in children to evaluate the efficacy compared to the standard St. Thomas solution. In this comparative study 15 children were treated with Celsior cardioplegic solution and 15 others with St. Thomas cardioplegic solution. Each patient underwent 2 biopsies of the myocardium, the first before cardioplegic treatment and the second immediately after reperfusion. In both groups, focal lesions involving both the cardiomyocytes and the vascular-stromal structures were randomly found. The former had undergone a necrotic-regressive process with changes in the myofibrils and the mitochondria. The vascular-stromal structures showed changes in the permeability of the capillary endothelia, with interstitial edema. The results show the lesions to be similar in the 2 groups both on a quality and quantitative level.

Published
2006

17. Trauma midollare dorsale in ratti. Studio sperimentale preliminare

Author

C. PARLATO, ACCARDO, Marina, V. CERVELLI, M. MORACI, BARBARISI, Manlio, L. CIUFFI, G. FASANO, M. GIORDANO, L. COLUMBANO, C. GRAGNANIELLO, M.A. SCAFURO, RS PARLATO, D. SQUILLANTE, L. FRASCADORE, A. MORACI, L. CUCCURULLO, F.A. CIOFFI, Parlato, C., Accardo, Marina, Cervelli, V., Moraci, M., Barbarisi, Manlio, Ciuffi, L., Fasano, G., Giordano, M., Columbano, L., Gragnaniello, C., Scafuro, M. A., Parlato, R, Squillante, D., Frascadore, L., Moraci, A., Cuccurullo, L., and Cioffi, F. A.

Published
2005

22. Gastroprotection by 4-methylpyrazole against ethanol in humans

Author

G, Iaquinto, M, Del Tacca, L, Cuccurullo, M C, Parodi, N, Giardullo, V, D'onofrio, G, Natale, D, Carignani, F, Ferraraccio, S, Szabo, Iaquinto, G, DEL TACCA, M, Cuccurullo, L, Parodi, Mc, Giardullo, N, D'Onofrio, V, Natale, G, Carignani, D, Ferraraccio, Franca, and Szabo, S.

Subjects
Adult, Fomepizole, Male, Ethanol, Biopsy, Premedication, Alcohol Dehydrogenase, Rats, Gastric Acid, Rats, Sprague-Dawley, Mucus, Gastric Mucosa, Animals, Humans, Pyrazoles, Lipid Peroxidation, Enzyme Inhibitors
Abstract

4-Methylpyrazole (4-MP), a specific inhibitor of alcohol dehydrogenase, exerts gastroprotection of unusually long duration in rats. We tested the hypothesis that pretreatment with 4-MP might protect the human gastric mucosa against alcohol-induced acute injury. Fourteen healthy volunteers received pretreatment with either 4-MP, 15 mg/kg body weight dissolved in 50 ml of orange juice, or placebo and 2 hr later 100 ml of 40% ethanol. The endoscopic appearance of the gastric mucosa was evaluated and scored (scale 0-5) and mucosal biopsies were obtained just before pretreatment and 30 min after ethanol for histologic examination and prostaglandin E2 measurement. In the 4-MP group the mean endoscopic injury score was significantly lower than that in placebo group, in both the body and the antrum. Histologically, 4-MP significantly reduced disruption of surface epithelium and completely prevented the deep hemorrhagic mucosal lesions. In the 4-MP group no changes in gastric mucosal PGE2 levels were detected. In rats, 4-MP did not inhibit gastric acid output, whereas it markedly increased the adherent gastric mucus evaluated by the alcian blue recovery method. When lipid peroxidation was induced by carbon tetrachloride in hepatic microsomes, 4-MP caused significant inhibition of malondialdehyde generation. We conclude that 4-MP provides significant protection of the human stomach against alcohol-induced acute mucosal injury. 4-MP, besides inhibiting the conversion of alcohol to acetaldehyde, might protect the gastric mucosa by increasing adherent gastric mucus and by scavenging free radicals.

Published
1998

24. Effect of ethanol on serum histamine levels in humans

Author

S. Szabo, F. Masucci, Nicola Giardullo, Italo Sorrentini, L. Pasquale, M.C. Parodi, F. Ferraraccio, V. D'Onofrio, L. Cuccurullo, C.A. De Vita, W. Taccone, and Gaetano Iaquinto

Subjects
chemistry.chemical_compound, Ethanol, Hepatology, chemistry, business.industry, Gastroenterology, Medicine, Pharmacology, business, Histamine
Published
2000

25. The May-Hegglin Anomaly

Author

Volpe E, G.P. Jori, Buonanno G, L. Cuccurullo, and Valente A

Subjects
Pathology, medicine.medical_specialty, business.industry, Stimulation, Hematology, General Medicine, medicine.disease, Coagulation, Hemostasis, May–Hegglin anomaly, Ultrastructure, Medicine, Platelet, Abnormality, business, Leukocyte inclusions
Abstract

A patient with the May-Hegglin anomaly is described with a clinical course characterized by spontaneous hemorrhages. Several studies on coagulation, hemostasis, and platelet functions did not reveal any abnormality. Cytochemical investigations were in good keeping with previous observations, and ultrastructural studies performed on platelets before and after ADP stimulation yielded normal results.

Published
1974

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