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1. Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model

Author: Marcos K. Andrade, Leonardo C. Souza, Evellyn M. Azevedo, Ellen L. Bail, Silvio M. Zanata, Roberto Andreatini, and Maria A.B.F. Vital
Subjects: History, Polymers and Plastics, General Neuroscience, Business and International Management, Industrial and Manufacturing Engineering
Published: 2023
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2. Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer’s Disease

Author: Leonardo C. Souza, Marcos K. Andrade, Evellyn M. Azevedo, Daniele C. Ramos, Ellen L. Bail, and Maria A. B. F. Vital
Subjects: General Neuroscience, Toxicology
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder clinically manifested by a gradual cognitive decline. Intracerebroventricular injection (ICV) of streptozotocin (STZ), a model of Sporadic AD (sAD), shows many aspects of sAD abnormalities (i.e., neuroinflammation, oxidative stress, protein aggregation) resulting in memory impairment. Andrographolide (ANDRO), a natural diterpene lactone, has numerous bioactivities including anti-inflammatory and antioxidant properties. Studies in rodents revealed that ANDRO has neuroprotective properties and restores cognitive impairment. In the present study, we investigated the effects of ANDRO in the ICV-STZ model relative to short-term spatial memory (Object location test (OLT) and Y maze test), short-term recognition memory (Object recognition test (ORT)), locomotor activity (Open field test (OFT)), expression of amyloid precursor protein (APP), and activation of astrocytes (glial fibrillary acidic protein (GFAP) expression) and microglia (ionized calcium-binding adapter molecule-1 (Iba-1) immunohistochemistry) in the prefrontal cortex (PFC) and hippocampus (HIP). Wistar rats were injected ICV with STZ (3 mg/kg) or vehicle and treated with ANDRO (2 mg/kg, i.p.; three times per week). After four weeks, ANDRO attenuated the impairments of the Y maze and ORT performances, and the increase of the astrocyte activation in the PFC induced by the ICV-STZ model. In addition, ANDRO decreased the number of activated microglia cells in the HIP of STZ-injected rats. The APP expression was not altered, neither by the STZ nor ANDRO. ANDRO showed a beneficial effect on memory impairment and neuroinflammation in the STZ model of AD.
Published: 2022
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3. Measurement of neutrino oscillation parameters with the first six detection units of KM3NeT/ORCA

Author: The KM3NeT collaboration, S. Aiello, A. Albert, A. R. Alhebsi, M. Alshamsi, S. Alves Garre, A. Ambrosone, F. Ameli, M. Andre, L. Aphecetche, M. Ardid, S. Ardid, H. Atmani, J. Aublin, F. Badaracco, L. Bailly-Salins, Z. Bardačová, B. Baret, A. Bariego-Quintana, Y. Becherini, M. Bendahman, F. Benfenati, M. Benhassi, M. Bennani, D. M. Benoit, E. Berbee, V. Bertin, S. Biagi, M. Boettcher, D. Bonanno, A. B. Bouasla, J. Boumaaza, M. Bouta, M. Bouwhuis, C. Bozza, R. M. Bozza, H. Brânzaş, F. Bretaudeau, M. Breuhaus, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, D. Calvo, A. Capone, F. Carenini, V. Carretero, T. Cartraud, P. Castaldi, V. Cecchini, S. Celli, L. Cerisy, M. Chabab, A. Chen, S. Cherubini, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, A. Condorelli, R. Coniglione, P. Coyle, A. Creusot, G. Cuttone, R. Dallier, A. De Benedittis, B. De Martino, G. De Wasseige, V. Decoene, I. Del Rosso, L. S. Di Mauro, I. Di Palma, A. F. Díaz, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, E. Drakopoulou, D. Drouhin, J.-G. Ducoin, R. Dvornický, T. Eberl, E. Eckerová, A. Eddymaoui, T. van Eeden, M. Eff, D. van Eijk, I. El Bojaddaini, S. El Hedri, V. Ellajosyula, A. Enzenhöfer, G. Ferrara, M. D. Filipović, F. Filippini, D. Franciotti, L. A. Fusco, S. Gagliardini, T. Gal, J. García Méndez, A. Garcia Soto, C. Gatius Oliver, N. Geißelbrecht, E. Genton, H. Ghaddari, L. Gialanella, B. K. Gibson, E. Giorgio, I. Goos, P. Goswami, S. R. Gozzini, R. Gracia, C. Guidi, B. Guillon, M. Gutiérrez, C. Haack, H. van Haren, A. Heijboer, L. Hennig, J. J. Hernández-Rey, W. Idrissi Ibnsalih, G. Illuminati, D. Joly, M. de Jong, P. de Jong, B. J. Jung, G. Kistauri, C. Kopper, A. Kouchner, Y. Y. Kovalev, V. Kueviakoe, V. Kulikovskiy, R. Kvatadze, M. Labalme, R. Lahmann, M. Lamoureux, G. Larosa, C. Lastoria, A. Lazo, S. Le Stum, G. Lehaut, V. Lemaître, E. Leonora, N. Lessing, G. Levi, M. Lindsey Clark, F. Longhitano, F. Magnani, J. Majumdar, L. Malerba, F. Mamedov, J. Mańczak, A. Manfreda, M. Marconi, A. Margiotta, A. Marinelli, C. Markou, L. Martin, M. Mastrodicasa, S. Mastroianni, J. Mauro, G. Miele, P. Migliozzi, E. Migneco, M. L. Mitsou, C. M. Mollo, L. Morales-Gallegos, A. Moussa, I. Mozun Mateo, R. Muller, M. R. Musone, M. Musumeci, S. Navas, A. Nayerhoda, C. A. Nicolau, B. Nkosi, B. Ó Fearraigh, V. Oliviero, A. Orlando, E. Oukacha, D. Paesani, J. Palacios González, G. Papalashvili, V. Parisi, E. J. Pastor Gomez, A. M. Păun, G. E. Păvălaş, S. Peña Martínez, M. Perrin-Terrin, V. Pestel, R. Pestes, P. Piattelli, A. Plavin, C. Poirè, V. Popa, T. Pradier, J. Prado, S. Pulvirenti, C. A. Quiroz-Rangel, N. Randazzo, S. Razzaque, I. C. Rea, D. Real, G. Riccobene, J. Robinson, A. Romanov, E. Ros, A. Šaina, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, S. Sanfilippo, M. Sanguineti, D. Santonocito, P. Sapienza, J. Schnabel, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, Y. Shitov, F. Šimkovic, A. Simonelli, A. Sinopoulou, B. Spisso, M. Spurio, D. Stavropoulos, I. Štekl, S. M. Stellacci, M. Taiuti, Y. Tayalati, H. Thiersen, S. Thoudam, I. Tosta e Melo, B. Trocmé, V. Tsourapis, A. Tudorache, E. Tzamariudaki, A. Ukleja, A. Vacheret, V. Valsecchi, V. Van Elewyck, G. Vannoye, G. Vasileiadis, F. Vazquez de Sola, A. Veutro, S. Viola, D. Vivolo, A. van Vliet, E. de Wolf, I. Lhenry-Yvon, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, and N. Zywucka
Subjects: Neutrino Detectors and Telescopes (experiments), Oscillation, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract KM3NeT/ORCA is a water Cherenkov neutrino detector under construction and anchored at the bottom of the Mediterranean Sea. The detector is designed to study oscillations of atmospheric neutrinos and determine the neutrino mass ordering. This paper focuses on an initial configuration of ORCA, referred to as ORCA6, which comprises six out of the foreseen 115 detection units of photo-sensors. A high-purity neutrino sample was extracted, corresponding to an exposure of 433 kton-years. The sample of 5828 neutrino candidates is analysed following a binned log-likelihood method in the reconstructed energy and cosine of the zenith angle. The atmospheric oscillation parameters are measured to be sin 2 θ 23 = 0.51 − 0.05 + 0.04 $$ {\sin}^2{\theta}_{23}={0.51}_{-0.05}^{+0.04} $$ , and Δ m 31 2 = 2.18 − 0.35 + 0.25 × 10 − 3 eV 2 ∪ − 2.25 − 1.76 × 10 − 3 $$ \Delta {m}_{31}^2={2.18}_{-0.35}^{+0.25}\times {10}^{-3}{\textrm{eV}}^2\cup \left\{-2.25,-1.76\right\}\times {10}^{-3} $$ eV2 at 68% CL. The inverted neutrino mass ordering hypothesis is disfavoured with a p-value of 0.25.
Published: 2024
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4. Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trialResearch in context

Author: O. Abani, A. Abbas, F. Abbas, J. Abbas, K. Abbas, M. Abbas, S. Abbasi, H. Abbass, A. Abbott, N. Abdallah, A. Abdelaziz, M. Abdelfattah, B. Abdelqader, A. Abdul, B. Abdul, S. Abdul, A. Abdul Rasheed, A. Abdulakeem, R. Abdul-Kadir, A. Abdullah, A. Abdulmumeen, R. Abdul-Raheem, N. Abdulshukkoor, K. Abdusamad, Y. Abed El Khaleq, M. Abedalla, A. Abeer Ul Amna, L. Abel, K. Abernethy, M. Abeywickrema, C. Abhinaya, A. Abidin, A. Aboaba, A. Aboagye-Odei, C. Aboah, H. Aboelela, H. Abo-Leyah, K. Abouelela, A. Abou-Haggar, M. Abouibrahim, A. Abousamra, M. Abouzaid, M. Abraham, T. Abraham, A. Abraheem, J. Abrams, R. Abrams, H.J. Abu, A. Abu-Arafeh, S.M. Abubacker, A. Abung, Y. Abusamra, Y. Aceampong, A. Achara, D. Acharya, F. Acheampong, P. Acheampong, S. Acheampong, J. Acheson, S. Achieng, A. Acosta, R. Acquah, C. Acton, J. Adabie-Ankrah, P. Adair, A.S. Adam, F. Adam, M. Adam, H. Adamali, M. Adamczyk, C. Adams, D. Adams, K. Adams, L. Adams, N. Adams, R. Adams, T. Adams, L. Adamu-Ikeme, K. Adatia, K. Adcock, L. Addai-Boampong, A. Addo, O. Adeagbo, A. Adebiyi, O. Adedeji, Y. Adegeye, K. Adegoke, V. Adell, S. Adenwalla, F.W. Adeoye, O.A. Adesemoye, E.O. Adewunmi, A. Adeyanju, J. Adeyemi, T. Adeyemo, B. Adhikari, S.A. Adhikari, R. Adhikary, A. Aditya, P. Adjepong, G. Adkins, A. Adnan, M. Adriaanse, J. Aeron-Thomas, D. Affleck, C. Afnan, M. Afridi, P. Afrim, F.A. Afriyie, Z.A. Aftab, A. Afum-Adjei Awuah, M. Agarwal, P.N. Agasiya, R. Agbeko, C. Agbo, S. Aggarwal, A. Aghababaie, L. Aguilar Jimenez, J.A. Agyekum, K. Agyen, E.K. Ahadome, S. Ahamed Sadiq, M.H. Ahammed Nazeer, M. Ahmad, S. Ahmad, A. Ahmed, B.A.R. Ahmed, B. Ahmed, F. Ahmed, H. Ahmed, I. Ahmed, K. Ahmed, L. Ahmed, M. Ahmed, M.C. Ahmed, M.S. Ahmed, N. Ahmed, O. Ahmed, R.A. Ahmed, R. Ahmed, S. Ahmed, S.G. Ahmed, S.H. Ahmed, R. Ahmed Ali, B. Ahmed Mohamud, S. Ahmer, A. Ahonia, C. Aidoo, C. Aiken, D. Ail, M. Ainsworth, M. Aissa, L. Aitken, B. Ajay, A. Ajibode, A. Ajmi, N. Akhtar, S. Akili, B. Akinbiyi, O. Akindolie, Y. Akinfenwa, O. Akinkugbe, I. Akinpelu, M. Akram, O. Aktinade, U. Akudi, A.S.A.R. Al Aaraj, A. Al Balushi, M. Al Dakhola, A. Al Swaifi, E. Al-Abadi, A. Alabi, N. Aladangady, M. Alafifi, A. Alam, S. Alam, A. Al-Asadi, K. Alatzoglou, P. Albert, A. Albertus, L. Albon, A. Alcala, G. Alcorn, S. Alcorn, A. Aldana, D. Alderdice, A. Aldesouki, R. Aldouri, J. Aldridge, N. Aldridge, R. Ale, R.M. Ale, A. Alegria, A. Alexander, C. Alexander, J. Alexander, P.D.G. Alexander, J. Al-fori, L. Alghazawi, O. Alhabsha, B. Al-Hakim, R. Alhameed, M. Al-Hayali, S. Al-Hity, A. Ali, F.R. Ali, J. Ali, M. Ali, M.S. Ali, N. Ali, O. Ali, R. Ali, S. Ali, E. Aliberti, J. Alin, A. Alina, A. Alipustain, B. Alisjahbana, F. Aliyuda, K. Alizadeh, M. Al-Jibury, S. Al-Juboori, M. Al-Khalil, A. Alkhudhayri, M. Alkhusheh, F. Allan, N. Allan, A. Allanson, R. Allcock, E. Allen, J. Allen, K. Allen, L. Allen, P. Allen, R. Allen, S. Allen, T. Allen, A. Alli, K. Allison, B. Allman, H.K. Allsop, L. Allsop, D. Allsup, A.F.T. Almahroos, H. Al-Moasseb, M. Al-Obaidi, L. Alomari, A. Al-Rabahi, B. Al-Ramadhani, Z. Al-Saadi, R. Al-Sammarraie, I. Alshaer, R. Al-Shahi Salman, W. Al-Shamkhani, F. Alsheikh, B. Al-Sheklly, S. Altaf, A. Alty, M. Alvarez, M. Alvarez Corral, E. Alveyn, M. Alzetani, S. Amamou, N. Amar, S. Ambalavanan, R. Ambrogetti, C. Ambrose, A. Ameen, A. Amelia Ganefianty, K. Ames, M.R. Amezaga, A. Amin, K. Amin, S. Amin, T. Amin, B. Amit, A. Amjad, N. Amjad, J. Amoah-Dankwa, A. Amoako-Adusei, V. Amosun, M. Amsal, K. Amsha, J. Amuasi, N. Amutio Martin, P. Amy, A. Anada, A. Anand, S. Anandappa, S.D. Anantapatnaikuni, N.K.N. Andari, E. Anderson, J. Anderson, L. Anderson, M. Anderson, N. Anderson, R. Anderson, S. Anderson, W. Anderson, P. Andreou, A. Andrews, J. Andrews, K. Aneke, A. Ang, W.W. Ang, T. Angel, A. Angela, P. Angelini, L. Anguvaa, O. Anichtchik, M. Anim-Somuah, K. Aniruddhan, J. Annett, L. Anning, M. Ansah, P.J. Anstey, R. Anstey, A. Anthony, A. Anthony-Pillai, P. Antill, Z. Antonina, V. Anu, M. Anwar, S. Anwar, E. Apetri, A. Apostolopoulos, S. Appleby, D. Appleyard, M.F. Aquino, B. Araba, S. Aransiola, M. Araujo, A. Archer, D. Archer, S. Archer, D. Arcoria, C. Ardley, G. Arhin-Sam, A.-M. Arias, O. Aribike, R. Arimoto, N.L.P.E. Arisanti, C. Arkley, C. Armah, I. Armata, J. Armistead, A. Armitage, C. Armstrong, M. Armstrong, S. Armstrong, W. Armstrong, P. Armtrong, H. Arndt, C. Arnison-Newgass, D. Arnold, R. Arnold, A. Arnott, D. Arora, K. Arora, P. Arora, R. Arora, A. Arter, A. Arthur, N.M. Artini, A. Arumaithurai, A. Arya, R. Arya, D. Aryal, D. Asandei, G.A. Asare, A. Asghar, M. Asghar, A. Ashab, C. Ashbrook-Raby, H. Ashby, J. Ashcroft, S. Ashcroft, G. Asher, Z. Ashfak, A. Ashfaq, H.A. Asiamah, A. Ashish, D. Ashley, S. Ashman-Flavell, S. Ashok, A.-E.-A. Ashour, M.Z. Ashraf, S. Ashraf, M.B. Ashraq, D. Ashton, S. Ashton, A. Ashworth, F.J. Ashworth, R. Ashworth, A. Aslam, I. Aslam, S. Aslam, L. Aslett, H. Asogan, A. Asrar, O. Assaf, R. Astin-Chamberlain, Y.E. Atabudzi, P. Athavale, D. Athorne, B. Atkins, C. Atkins, S. Atkins, J. Atkinson, V. Atkinson, A. Atomode, B. Atraskiewicz, A.A. Attia, E. Attubato, M. Attwood, P. Aubrey, Z. Auer, A. Aujayeb, A.T. Aung, H. Aung, H.W.W. Aung, K.K. Aung, K.T. Aung, N. Aung, Y. Aung, Z.M. Aung, E. Austin, K. Austin, A. Auwal, M. Avari, M. Avery, N. Aveyard, J. Avis, G. Aviss, C. Avram, P. Avram, A. Awadelkareem, G. Awadzi, M. Awaly, A. Awan, S. Awisi, A. Aya, E. Ayaz, J.M. Ayerh, A. Ayers, J. Azam, A. Azeem, M. Azharuddin, A. Aziz, G. Aziz, I. Aziz, N. Aziz, A. Azkoul, A. Azman Shah, G. Azzopardi, H. Azzoug, F. Babatunde, M. Babi, B. Babiker, G. Babington, M. Babirecki, M. Babores, A.O. Babs-Osibodu, T. Bac, S. Bacciarelli, R. Bachar, M.-E. Bachour, A. Bachti, G. Bacon, J. Bacon, B. Badal, A. Badat, M. Bader, G.R. Badhan, S. Badhrinarayanan, J.P. Bae, A. Baggaley, A. Baggott, G. Bagley, D. Bagmane, L. Bagshaw, K. Bahadori, Y. Bahurupi, A. Bailey, J. Bailey, K. Bailey, L. Bailey, M.A. Bailey, M. Bailey, P. Bailey, S. Bailey, H. Baillie, J.K. Baillie, J. Bain, V. Bains, D. Baird, E. Baird, K. Baird, S. Baird, T. Baird, Y. Baird, A. Bajandouh, M. Bajracharya, D.C. Baker, E. Baker, J. Baker, K. Baker, M. Baker, R. Baker, T.-A. Baker, V. Baker, H. Bakere, N. Bakerly, M. Baker-Moffatt, A. Bakhai, N. Bakhtiar, P. Bakoulas, D. Bakthavatsalam, N. Balachandran, A. Balan, P. Balasingam, T. Balaskas, M. Balasubramaniam, N. Balatoni, A. Balcombe, A. Baldwin, C. Baldwin, D. Baldwin, F. Baldwin, R. Baldwin-Jones, N. Bale, J. Balfour, M. Ball, Ro Ball, K. Ballard, I. Balluz, C. Balmforth, E. Balogh, A. Baltmr, A. Baluwala, G. Bambridge, A. Bamford, P. Bamford, A. Bamgboye, E. Bancroft, H. Bancroft, J. Banda, K. Bandaru, S. Bandi, N. Bandla, S. Bandyopadhyam, A. Banerjee, R. Banerjee, P. Bang, S. Baniya, O. Bani-Saad, H. Banks, L. Banks, P. Banks, C. Bann, H. Bannister, O. Bannister, L. Banton, D.G. Bao, T. Bao, M. Baptist, T. Baqai, A.M. Baral, S.C. Baral, D. Baramova, R. Barber, E. Barbon, M. Barbosa, J. Barbour, A. Barclay, C. Barclay, G. Bardsley, S. Bareford, S. Bari, M. Barimbing, A. Barker, D. Barker, E. Barker, H. Barker, J. Barker, L. Barker, O. Barker, K. Barker-Williams, S. Barkha, J. Barla, G. Barlow, R. Barlow, V. Barlow, J. Barnacle, A. Barnard, D. Barnes, N. Barnes, R. Barnes, T. Barnes, C. Barnetson, A. Barnett, A. Barnett-Vanes, P.G. Barning, W. Barnsley, A. Barr, D. Barr, J. Barr, C. Barr, N. Barratt, S. Barratt, M. Barrera, A. Barrett, Fi Barrett, J. Barrett, S. Barrett, E. Barrow, J. Bartholomew, M.S. Barthwal, C. Bartlett, G. Bartlett, J. Bartlett, L. Bartlett, S. Bartley, S. Bartolmeu-Pires, A. Barton, G. Barton, J. Barton, L. Barton, R. Barton, R. Baruah, S. Baryschpolec, H. Bashir, A. Bashyal, B. Basker, S. Basnet, B. Basnyat, A. Basoglu, A. Basran, J. Bassett, G. Bassett, C. Bassford, B. Bassoy, V. Bastion, A. Bastola, A. Basumatary, P. Basvi, J.A. Batac, V.R. Bataduwaarachchi, T. Bate, H.J. Bateman, K. Bateman, V. Bateman, E. Bates, H. Bates, M. Bates, S. Bates, S. Batham, A. Batista, A. Batla, D. Batra, H. Batty, T. Batty, A. Batty, M. Baum, R. Baumber, C. Bautista, F. Bawa, T. Bawa, F.S. Bawani, S. Bax, M. Baxter, N. Baxter, Z. Baxter, H. Bayes, L.-A. Bayo, F. Bazari, R. Bazaz, A. Bazli, L. Beacham, W. Beadles, K. Beadon, P. Beak, A. Beale, K. Beard, J. Bearpark, A. Beasley, S. Beattie, K. Beaumont, D. Beaumont-Jewell, T. Beaver, S. Beavis, C. Beazley, S. Beck, V. Beckett, R. Beckitt, S. Beckley, H. Beddall, S. Beddows, D. Beeby, S. Beeby, G. Beech, M. Beecroft, N. Beer, Sa Beer, J. Beety, G. Bega, A. Begg, S. Begg, S. Beghini, A. Begum, S. Begum, T. Behan, R. Behrouzi, J. Beishon, C. Beith, J. Belcher, H. Belfield, K. Belfield, A. Belgaumkar, D. Bell, G. Bell, J. Bell, L. Bell, N. Bell, P. Bell, S. Bell, J. Bellamu, M. Bellamy, T. Bellamy, A. Bellini, A. Bellis, F. Bellis, L. Bendall, N. Benesh, N. Benetti, S.A. Bengu, L. Benham, G. Benison-Horner, S. Benkenstein, T. Benn, A. Bennett, C. Bennett, D. Bennett, G. Bennett, K. Bennett, L. Bennett, M.R. Bennett, S. Bennett, K. Bennion, G. Benoy, V. Benson, A. Bentley, J. Bentley, I. Benton, E. Beranova, M. Beresford, C. Bergin, M. Bergstrom, J. Bernatoniene, T. Berriman, Z. Berry, F. Best, K. Best, A.-M. Bester, Y. Beuvink, E. Bevan, S. Bevins, T. Bewick, A. Bexley, S. Beyatli, F. Beynon, A. Bhadi, S. Bhagani, S. Bhakta, R. Bhalla, K. Bhandal, A. Bhandari, L. Bhandari, L.N. Bhandari, S. Bhandari, J. Bhanich Supapol, A. Bhanot, R. Bhanot, S. Bhasin, A. Bhat, P. Bhat, R. Bhatnagar, K. Bhatt, J. Bhayani, D. Bhojwani, P. Bhuie, M.S. Bhuiyan, S. Bhuiyan, A. Bibby, F. Bibi, N. Bibi, S. Bibi, T. Bicanic, S. Bidgood, J. Bigg, S. Biggs, A. Biju, A. Bikov, S. Billingham, J. Billings, P. Binh, A. Binns, M. BinRofaie, O. Bintcliffe, C. Birch, J. Birch, K. Birchall, S. Bird, M. Birt, C. Bishop, K. Bishop, L. Bishop, K. Bisnauthsing, N. Biswas, M. Bittaye, S. Biuk, K. Blachford, E. Black, H. Black, K. Black, M. Black, P. Black, V. Black, H. Blackgrove, B. Blackledge, J. Blackler, S. Blackley, H. Blackman, C. Blackstock, C. Blair, F. Blakemore, H. Blamey, A. Bland, S. Blane, S. Blankley, P. Blaxill, K. Blaylock, J. Blazeby, N. Blencowe, B. Bloom, J. Bloomfield, A. Bloss, A. Blowers, S. Blows, H. Bloxham, S. Blrd, L. Blundell, A. Blunsum, M. Blunt, T. Blunt, I. Blyth, K. Blyth, A. Blythe, K. Blythe, K.A. Boahen, M. Boampoaa, S. Board, E. Boatemah, B. Bobie, K. Bobruk, P.N. Bodalia, N. Bodasing, M. Boden, T. Bodenham, G. Boehmer, M. Boffito, K. Bohanan, K. Bohmova, N. Bohnacker, S. Bokhandi, M. Bokhar, S. Bokhari, S.O. Bokhari, I. Bokobza, A. Boles, C. Bolger, C. Bonaconsa, C. Bond, H. Bond, S. Bond, T. Bond, A. Bone, G. Boniface, J. Bonney, L. Bonney, L. Booker, S. Boot, M. Boothroyd, J. Borbone, N. Borman, S. Bosence, K. Bostock, N. Botting, F. Bottrill, H. Bouattia, L. Bough, H. Boughton, Z. Boult, T. Boumrah, M. Bourke, S. Bourke, M. Bourne, R. Bousfield, L. Boustred, A. Bowes, P. Bowker, T. Bowker, H. Bowler, L. Bowman, S. Bowman, R. 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Subjects: COVID-19, Corticosteroid, Dexamethasone, Mortality, Clinical trial, Medicine (General), R5-920
Abstract: Summary: Background: Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients. We have previously reported that higher dose corticosteroids cause harm in patients with clinical hypoxia but not receiving ventilatory support (the combination of non-invasive mechanical ventilation, including high-flow nasal oxygen, continuous positive airway pressure and bilevel positive airway pressure ventilation, and invasive mechanical ventilation or extra-corporeal membrane oxygenation), but the balance of efficacy and safety in patients receiving ventilatory support is uncertain. Methods: This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) assessed multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients receiving ventilatory support were randomly allocated (1:1) to either usual care with higher dose corticosteroids (dexamethasone 20 mg once daily for 5 days followed by 10 mg once daily for 5 days or until discharge if sooner) or usual standard of care alone (which includes dexamethasone 6 mg once daily for 10 days or until discharge if sooner). The primary outcome was 28-day mortality; secondary outcomes were duration of hospitalisation and (among participants not on invasive mechanical ventilation at baseline) the composite of invasive mechanical ventilation or death. Recruitment closed on 31 March 2024 when funding for the trial ended. The RECOVERY trial is registered with ISRCTN (50189673) and clinicaltrials.gov (NCT04381936). Findings: Between 25 May 2021 and 9 January 2024, 477 COVID-19 patients receiving ventilatory support were randomly allocated to receive usual care plus higher dose corticosteroids vs. usual care alone (of whom 99% received corticosteroids during the follow-up period). Of those randomised, 221 (46%) were in Asia, 245 (51%) in the UK and 11 (2%) in Africa. 143 (30%) had diabetes mellitus. Overall, 86 (35%) of 246 patients allocated to higher dose corticosteroids vs. 86 (37%) of 231 patients allocated to usual care died within 28 days (rate ratio [RR] 0.87; 95% CI 0.64–1.18; p = 0.37). There was no significant difference in the proportion of patients discharged from hospital alive within 28 days (128 [52%] in the higher dose corticosteroids group vs. 120 [52%] in the usual care group; RR 1.04, 0.81–1.33]; p = 0.78). Among those not on invasive mechanical ventilation at baseline, there was no clear reduction in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (76 [37%] of 206 vs. 93 [45%] of 205; RR 0.79 [95% CI 0.63–1.00]; p = 0.05). Interpretation: In patients hospitalised for COVID-19 receiving ventilatory support, we found no evidence that higher dose corticosteroids reduced the risk of death compared to usual care, which included low dose corticosteroids. Funding: UK Research and Innovation (Medical Research Council) and National Institute for Health Research (Grant ref: MC_PC_19056), and Wellcome Trust (Grant Ref: 222406/Z/20/Z).
Published: 2025
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5. Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort studyResearch in context

Author: Safoora Gharibzadeh, Ash Routen, Cameron Razieh, Francesco Zaccardi, Claire Lawson, Clare Gillies, Simon Heller, Melanie Davies, Helen Atkins, Stephen C. Bain, Nazir L. Lone, Krisnah Poinasamy, Tunde Peto, Elizabeth Robertson, Bob Young, Desmond Johnston, Jennifer Quint, Jonathan Valabhji, Khalida Ismail, Michael Marks, Alex Horsley, Annemarie Docherty, Ewen Harrison, James Chalmers, Ling-Pei Ho, Betty Raman, Chris Brightling, Omer Elneima, Rachel Evans, Neil Greening, Victoria C. Harris, Linzy Houchen-Wolloff, Marco Sereno, Aarti Shikotra, Amisha Singapuri, Louise Wain, Claudia Langenberg, John Dennis, John Petrie, Naveed Sattar, Olivia Leavy, Mattew Richardson, Ruth M. Saunders, Anne McArdle, Hamish McASuley, Tom Yates, Kamlesh Khunti, C.E. Brightling, R.A. Evans, L.V. Wain, J.D. Chalmers, V.C. Harris, L.P. Ho, A. Horsley, M. Marks, K. Poinasamy, B. Raman, A. Shikotra, A. Singapuri, R. Dowling, C. Edwardson, O. Elneima, S. Finney, N.J. Greening, B. Hargadon, L. Houchen--Wolloff, O.C. Leavy, H.J.C. McAuley, C. Overton, T. Plekhanova, R.M. Saunders, M. Sereno, C. Taylor, S. Terry, C. Tong, B. Zhao, D. Lomas, E. Sapey, C. Berry, C.E. Bolton, N. Brunskill, E.R. Chilvers, R. Djukanovic, Y. Ellis, D. Forton, N. French, J. George, N.A. Hanley, N. Hart, L. McGarvey, N. Maskell, H. McShane, M. Parkes, D. Peckham, P. Pfeffer, A. Sayer, A. Sheikh, A.A.R. Thompson, N. Williams, W. Greenhalf, M.G. Semple, M. Ashworth, H.E. Hardwick, L. Lavelle-Langham, W. Reynolds, V. Shaw, B. Venson, A.B. Docherty, E.M. Harrison, J.K. Baillie, L. Daines, R. Free, S. Kerr, N.I. Lone, D. Lozano-Rojas, K. Ntotsis, R. Pius, J. Quint, M. Richardson, M. Thorpe, M. Halling-Brown, F. Gleeson, J. Jacob, S. Neubauer, S. Siddiqui, J.M. Wild, S. Aslani, G. Baxter, M. Beggs, C. Bloomfield, M.P. Cassar, A. Chiribiri, E. Cox, D.J. Cuthbertson, V.M. Ferreira, L. Finnigan, S. Francis, P. Jezzard, G.J. Kemp, H. Lamlum, E. Lukaschuk, C. Manisty, G.P. McCann, C. McCracken, K. McGlynn, R. 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Barker, D. Cristiano, N. Dormand, M. Gummadi, S. Kon, K. Liyanage, C.M. Nolan, S. Patel, O. Polgar, P. Shah, J.A. Walsh, H. Jarvis, S. Mandal, S. Ahmad, S. Brill, L. Lim, D. Matila, O. Olaosebikan, C. Singh, L. Garner, C. Johnson, J. Mackie, A. Michael, J. Pack, K. Paques, H. Parfrey, J. Parmar, N. Diar Bakerly, P. Dark, D. Evans, E. Hardy, A. Harvey, D. Holgate, S. Knight, N. Mairs, N. Majeed, L. McMorrow, J. Oxton, J. Pendlebury, C. Summersgill, R. Ugwuoke, S. Whittaker, W. Matimba-Mupaya, S. Strong-Sheldrake, J. Bagshaw, M. Begum, K. Birchall, R. Butcher, H. Carborn, F. Chan, K. Chapman, Y. Cheng, L. Chetham, C. Clark, Z. Coburn, J. Cole, M. Dixon, A. Fairman, J. Finnigan, H. Foot, D. Foote, A. Ford, R. Gregory, K. Harrington, L. Haslam, L. Hesselden, J. Hockridge, A. Holbourn, B. Holroyd-Hind, L. Holt, A. Howell, E. Hurditch, F. Ilyas, C. Jarman, E. Lee, J.-H. Lee, R. Lenagh, A. Lye, I. Macharia, M. Marshall, A. Mbuyisa, J. McNeill, S. Megson, J. Meiring, L. Milner, S. Misra, H. Newell, T. Newman, C. Norman, L. Nwafor, D. Pattenadk, M. Plowright, P. Ravencroft, C. Roddis, J. Rodger, P. Saunders, J. Sidebottom, J. Smith, L. Smith, N. Steele, G. Stephens, R. Stimpson, B. Thamu, N. Tinker, K. Turner, H. Turton, P. Wade, J. Watson, I. Wilson, A. Zawia, M. Ali, A. Dunleavy, N. Msimanga, M. Mencias, T. Samakomva, S. Siddique, J. Teixeira, V. Tavoukjian, J. Hutchinson, L. Allsop, K. Bennett, P. Buckley, M. Flynn, M. Gill, C. Goodwin, M. Greatorex, H. Gregory, C. Heeley, L. Holloway, M. Holmes, J. Kirk, W. Lovegrove, T.A. Sewell, S. Shelton, D. Sissons, K. Slack, S. Smith, D. Sowter, S. Turner, V. Whitworth, I. Wynter, L. Warburton, S. Painter, J. Tomlinson, C. Vickers, T. Wainwright, D. Redwood, J. Tilley, S. Palmer, G.A. Davies, L. Connor, A. Cook, T. Rees, F. Thaivalappil, C. Thomas, A. Butt, M. Coulding, S. Kilroy, J. McCormick, J. McIntosh, H. Savill, V. Turner, J. Vere, E. Fraile, J. Ugoji, S.S. Kon, H. Lota, G. Landers, M. Nasseri, S. Portukhay, A. Hormis, A. Daniels, J. Ingham, L. Zeidan, M. Chablani, L. Osborne, N. Ahwireng, B. Bang, D. Basire, A. Checkley, R. Evans, M. Heightman, T. Hillman, S. Janes, R. Jastrub, M. Lipman, S. Logan, M. Merida Morillas, H. Plant, J.C. Porter, K. Roy, E. Wall, B. Williams, N. Ahmad Haider, C. Atkin, R. Baggott, M. Bates, A. Botkai, A. Casey, B. Cooper, J. Dasgin, K. Draxlbauer, N. Gautam, J. Hazeldine, T. Hiwot, S. Holden, K. Isaacs, V. Kamwa, D. Lewis, S. Madathil, C. McGhee, K. Mcgee, A. Neal, A. Newton Cox, J. Nyaboko, Z. Peterkin, H. Qureshi, L. Ratcliffe, J. Short, T. Soulsby, J. Stockley, Z. Suleiman, T. Thompson, M. Ventura, S. Walder, C. Welch, S. Yasmin, K.P. Yip, P. Beckett, C. Dickens, U. Nanda, M. Aljaroof, H. Arnold, H. Aung, M. Bakali, M. Bakau, M. Bingham, M. Bourne, C. Bourne, P. Cairns, L. Carr, A. Charalambou, C. Christie, S. Diver, S. Edwards, H. Evans, J. Finch, S. Glover, N. Goodman, B. Gootpu, K. Hadley, P. Haldar, W. Ibrahim, L. Ingram, A. Lea, D. Lee, P. McCourt, T. Mcnally, A. Moss, W. Monteiro, M. Pareek, S. Parker, A. Rowland, A. Prickett, I.N. Qureshi, R. Russell, N. Samani, M. Sharma, J. Skeemer, M. Soares, E. Stringer, T. Thornton, M. Tobin, E. Turner, T.J.C. Ward, F. Woodhead, J. Wormleighton, A. Yousuf, C. Childs, S. Fletcher, M. Harvey, E. Marouzet, B. Marshall, R. Samuel, T. Sass, T. Wallis, H. Wheeler, R. Dharmagunawardena, E. Bright, P. Crisp, M. Stern, A. Wight, L. Bailey, A. Reddington, A. Ashish, J. Cooper, E. Robinson, A. Broadley, K. Howard, L. Barman, C. Brookes, K. Elliott, L. Griffiths, Z. Guy, D. Ionita, H. Redfearn, C. Sarginson, A. Turnbull, K. Holmes, and K. Lewis
Subjects: Diabetes, Covid-19, Long Covid, Medicine (General), R5-920
Abstract: Summary: Background: People with diabetes are at increased risk of hospitalisation, morbidity, and mortality following SARS-CoV-2 infection. Long-term outcomes for people with diabetes previously hospitalised with COVID-19 are, however, unknown. This study aimed to determine the longer-term physical and mental health effects of COVID-19 in people with and without diabetes. Methods: The PHOSP-COVID study is a multicentre, long-term follow-up study of adults discharged from hospital between 1 February 2020 and 31 March 2021 in the UK following COVID-19, involving detailed assessment at 5 and 12 months after discharge. The association between diabetes status and outcomes were explored using multivariable linear and logistic regressions. Findings: People with diabetes who survived hospital admission with COVID-19 display worse physical outcomes compared to those without diabetes at 5- and 12-month follow-up. People with diabetes displayed higher fatigue (only at 5 months), frailty, lower physical performance, and health-related quality of life and poorer cognitive function. Differences in outcomes between diabetes status groups were largely consistent from 5 to 12-months. In regression models, differences at 5 and 12 months were attenuated after adjustment for BMI and presence of other long-term conditions. Interpretation: People with diabetes reported worse physical outcomes up to 12 months after hospital discharge with COVID-19 compared to those without diabetes. These data support the need to reduce inequalities in long-term physical and mental health effects of SARS-CoV-2 infection in people with diabetes. Funding: UK Research and Innovation and National Institute for Health Research. The study was approved by the Leeds West Research Ethics Committee (20/YH/0225) and is registered on the ISRCTN Registry (ISRCTN10980107).
Published: 2025
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6. Astronomy potential of KM3NeT/ARCA

Author: KM3NeT Collaboration, S. Aiello, A. Albert, M. Alshamsi, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, E. Androutsou, M. Anguita, L. Aphecetche, M. Ardid, S. Ardid, H. Atmani, J. Aublin, F. Badaracco, L. Bailly-Salins, Z. Bardačová, B. Baret, A. Bariego-Quintana, A. Baruzzi, S. Basegmez du Pree, Y. Becherini, M. Bendahman, F. Benfenati, M. Benhassi, D. M. Benoit, E. Berbee, V. Bertin, S. Biagi, M. Boettcher, D. Bonanno, J. Boumaaza, M. Bouta, M. Bouwhuis, C. Bozza, R. M. Bozza, H. Brânzaş, F. Bretaudeau, M. Breuhaus, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, D. Calvo, S. Campion, A. Capone, F. Carenini, V. Carretero, T. Cartraud, P. Castaldi, V. Cecchini, S. Celli, L. Cerisy, M. Chabab, M. Chadolias, A. Chen, S. Cherubini, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, R. Coniglione, P. Coyle, A. Creusot, G. Cuttone, R. Dallier, Y. Darras, A. De Benedittis, B. De Martino, V. Decoene, R. Del Burgo, I. Del Rosso, L. S. Di Mauro, I. Di Palma, A. F. Díaz, C. Diaz, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, E. Drakopoulou, D. Drouhin, J.-G. Ducoin, R. Dvornický, T. Eberl, E. Eckerová, A. Eddymaoui, T. van Eeden, M. Eff, D. van Eijk, I. El Bojaddaini, S. El Hedri, A. Enzenhöfer, G. Ferrara, M. D. Filipović, F. Filippini, D. Franciotti, L. A. Fusco, J. Gabriel, S. Gagliardini, T. Gal, J. García Méndez, A. Garcia Soto, C. Gatius Oliver, N. Geißelbrecht, H. Ghaddari, L. Gialanella, B. K. Gibson, E. Giorgio, I. Goos, P. Goswami, D. Goupilliere, S. R. Gozzini, R. Gracia, K. Graf, C. Guidi, B. Guillon, M. Gutiérrez, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J. J. Hernández-Rey, W. Idrissi Ibnsalih, G. Illuminati, M. de Jong, P. de Jong, B. J. Jung, P. Kalaczyński, O. Kalekin, U. F. Katz, G. Kistauri, C. Kopper, A. Kouchner, V. Kueviakoe, V. Kulikovskiy, R. Kvatadze, M. Labalme, R. Lahmann, G. Larosa, C. Lastoria, A. Lazo, S. Le Stum, G. Lehaut, E. Leonora, N. Lessing, G. Levi, M. Lindsey Clark, F. Longhitano, F. Magnani, J. Majumdar, L. Malerba, F. Mamedov, J. Mańczak, A. Manfreda, M. Marconi, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J. A. Martínez-Mora, F. Marzaioli, M. Mastrodicasa, S. Mastroianni, S. Miccichè, G. Miele, P. Migliozzi, E. Migneco, M. L. Mitsou, C. M. Mollo, L. Morales-Gallegos, M. Morga, A. Moussa, I. Mozun Mateo, R. Muller, M. R. Musone, M. Musumeci, S. Navas, A. Nayerhoda, C. A. Nicolau, B. Nkosi, B. Ó Fearraigh, V. Oliviero, A. Orlando, E. Oukacha, D. Paesani, J. Palacios González, G. Papalashvili, V. Parisi, E. J. Pastor Gomez, A. M. Păun, G. E. Păvălaş, I. Pelegris, S. Peña Martínez, M. Perrin-Terrin, J. Perronnel, V. Pestel, R. Pestes, P. Piattelli, C. Poirè, V. Popa, T. Pradier, J. Prado, S. Pulvirenti, C. A. Quiroz-Rangel, U. Rahaman, N. Randazzo, R. Randriatoamanana, S. Razzaque, I. C. Rea, D. Real, G. Riccobene, J. Robinson, A. Romanov, A. Šaina, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, S. Sanfilippo, M. Sanguineti, C. Santonastaso, D. Santonocito, P. Sapienza, J. Schnabel, J. Schumann, H. M. Schutte, J. Seneca, N. Sennan, B. Setter, I. Sgura, R. Shanidze, A. Sharma, Y. Shitov, F. Šimkovic, A. Simonelli, A. Sinopoulou, M. V. Smirnov, B. Spisso, M. Spurio, D. Stavropoulos, I. Štekl, M. Taiuti, Y. Tayalati, H. Thiersen, I. Tosta e Melo, E. Tragia, B. Trocmé, V. Tsourapis, A. Tudorache, E. Tzamariudaki, A. Vacheret, A. Valer Melchor, V. Valsecchi, V. Van Elewyck, G. Vannoye, G. Vasileiadis, F. Vazquez de Sola, C. Verilhac, A. Veutro, S. Viola, D. Vivolo, J. Wilms, E. de Wolf, H. Yepes-Ramirez, G. Zarpapis, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, and N. Zywucka
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The KM3NeT/ARCA neutrino detector is currently under construction at 3500 m depth offshore Capo Passero, Sicily, in the Mediterranean Sea. The main science objectives are the detection of high-energy cosmic neutrinos and the discovery of their sources. Simulations were conducted for the full KM3NeT/ARCA detector, instrumenting a volume of 1 km $$^3$$ 3 , to estimate the sensitivity and discovery potential to point-like neutrino sources. This paper covers the reconstruction of track- and shower-like signatures, as well as the criteria employed for neutrino event selection. With an angular resolution below 0.1 $$^\circ $$ ∘ for tracks and under 2 $$^\circ $$ ∘ for showers, the sensitivity to point-like neutrino sources surpasses existing observed limits across the entire sky.
Published: 2024
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7. Atmospheric muons measured with the KM3NeT detectors in comparison with updated numeric predictions

Author: KM3NeT Collaboration, S. Aiello, A. Albert, M. Alshamsi, S. Alves Garre, A. Ambrosone, F. Ameli, M. Andre, E. Androutsou, M. Anguita, L. Aphecetche, M. Ardid, S. Ardid, A. Arsenic, H. Atmani, J. Aublin, F. Badaracco, L. Bailly-Salins, Z. Bardačová, B. Baret, A. Bariego-Quintana, S. Basegmez du Pree, Y. Becherini, M. Bendahman, F. Benfenati, M. Benhassi, D. M. Benoit, E. Berbee, V. Bertin, S. Biagi, M. Boettcher, D. Bonanno, J. Boumaaza, M. Bouta, M. Bouwhuis, C. Bozza, R. M. Bozza, H. Brânzaş, F. Bretaudeau, M. Breuhaus, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, D. Calvo, S. Campion, A. Capone, F. Carenini, V. Carretero, T. Cartraud, P. Castaldi, V. Cecchini, S. Celli, L. Cerisy, M. Chabab, M. Chadolias, A. Chen, S. Cherubini, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, A. Condorelli, R. Coniglione, P. Coyle, A. Creusot, G. Cuttone, R. Dallier, Y. Darras, A. De Benedittis, B. De Martino, V. Decoene, R. Del Burgo, I. Del Rosso, L. S. Di Mauro, I. Di Palma, A. F. Díaz, C. Diaz, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, E. Drakopoulou, D. Drouhin, J.-G. Ducoin, R. Dvornický, T. Eberl, E. Eckerová, A. Eddymaoui, T. van Eeden, M. Eff, D. van Eijk, I. El Bojaddaini, S. El Hedri, A. Enzenhöfer, G. Ferrara, M. D. Filipović, F. Filippini, D. Franciotti, L. A. Fusco, S. Gagliardini, T. Gal, J. García Méndez, A. Garcia Soto, C. Gatius Oliver, N. Geißelbrecht, H. Ghaddari, L. Gialanella, B. K. Gibson, E. Giorgio, I. Goos, P. Goswami, S. R. Gozzini, R. Gracia, K. Graf, C. Guidi, B. Guillon, M. Gutiérrez, C. Haack, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J. J. Hernández-Rey, W. Idrissi Ibnsalih, G. Illuminati, D. Joly, M. de Jong, P. de Jong, B. J. Jung, P. Kalaczyński, O. Kalekin, U. F. Katz, A. Khatun, G. Kistauri, C. Kopper, A. Kouchner, V. Kueviakoe, V. Kulikovskiy, R. Kvatadze, M. Labalme, R. Lahmann, G. Larosa, C. Lastoria, A. Lazo, S. Le Stum, G. Lehaut, E. Leonora, N. Lessing, G. Levi, F. Longhitano, F. Magnani, J. Majumdar, L. Malerba, F. Mamedov, J. Mańczak, A. Manfreda, M. Marconi, A. Margiotta, A. Marinelli, C. Markou, L. Martin, F. Marzaioli, M. Mastrodicasa, S. Mastroianni, S. Miccichè, G. Miele, P. Migliozzi, E. Migneco, M. L. Mitsou, C. M. Mollo, L. Morales-Gallegos, G. Moretti, A. Moussa, I. Mozun Mateo, R. Muller, M. R. Musone, M. Musumeci, S. Navas, A. Nayerhoda, C. A. Nicolau, B. Nkosi, B. Ó. Fearraigh, V. Oliviero, A. Orlando, E. Oukacha, D. Paesani, J. Palacios González, G. Papalashvili, V. Parisi, E. J. Pastor Gomez, A. M. Păun, G. E. Păvălaş, I. Pelegris, S. Peña Martínez, M. Perrin-Terrin, J. Perronnel, V. Pestel, R. Pestes, P. Piattelli, C. Poirè, V. Popa, T. Pradier, J. Prado, S. Pulvirenti, C. A. Quiroz-Rangel, U. Rahaman, N. Randazzo, S. Razzaque, I. C. Rea, D. Real, G. Riccobene, J. Robinson, A. Romanov, A. Šaina, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, S. Sanfilippo, M. Sanguineti, C. Santonastaso, D. Santonocito, P. Sapienza, J. Schnabel, J. Schumann, H. M. Schutte, J. Seneca, N. Sennan, B. Setter, I. Sgura, R. Shanidze, A. Sharma, Y. Shitov, F. Šimkovic, A. Simonelli, A. Sinopoulou, M. V. Smirnov, B. Spisso, M. Spurio, D. Stavropoulos, I. Štekl, M. Taiuti, Y. Tayalati, H. Thiersen, I. Tosta e Melo, E. Tragia, B. Trocmé, V. Tsourapis, A. Tudorache, E. Tzamariudaki, A. Vacheret, A. Valer Melchor, V. Valsecchi, V. Van Elewyck, G. Vannoye, G. Vasileiadis, F. Vazquez de Sola, A. Veutro, S. Viola, D. Vivolo, J. Wilms, E. de Wolf, H. Yepes-Ramirez, I. Yvon, G. Zarpapis, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, and N. Zywucka
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The measurement of the flux of muons produced in cosmic ray air showers is essential for the study of primary cosmic rays. Such measurements are important in extensive air shower detectors to assess the energy spectrum and the chemical composition of the cosmic ray flux, complementary to the information provided by fluorescence detectors. Detailed simulations of the cosmic ray air showers are carried out, using codes such as CORSIKA, to estimate the muon flux at sea level. These simulations are based on the choice of hadronic interaction models, for which improvements have been implemented in the post-LHC era. In this work, a deficit in simulations that use state-of-the-art QCD models with respect to the measurement deep underwater with the KM3NeT neutrino detectors is reported. The KM3NeT/ARCA and KM3NeT/ORCA neutrino telescopes are sensitive to TeV muons originating mostly from primary cosmic rays with energies around 10 TeV. The predictions of state-of-the-art QCD models show that the deficit with respect to the data is constant in zenith angle; no dependency on the water overburden is observed. The observed deficit at a depth of several kilometres is compatible with the deficit seen in the comparison of the simulations and measurements at sea level.
Published: 2024
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8. Predicción de los resultados clínicos en el tratamiento personalizado con yodo radiactivo de la enfermedad de Graves, mediante gammagrafía tiroidea con 99mTc-pertecnetato

Author: L Zhao, Y Xin, L Bail, F Guan, W Zhang, B Ji Bin, and Q Wen
Subjects: Gynecology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, medicine, 030209 endocrinology & metabolism, Radiology, Nuclear Medicine and imaging, business, 030218 nuclear medicine & medical imaging
Abstract: espanolObjetivo El objetivo de este estudio fue, en primer lugar, la comprobacion de la eficacia de la terapia con yodo radiactivo (TIR) en la enfermedad de Graves (EG) basandonos en un regimen de calculo de dosis y, en segundo lugar, determinar el valor de la gammagrafia tiroidea con 99mTc-pertecnetato a la hora de predecir los resultados clinicos de la TIR. Metodos Evaluamos retrospectivamente a 139 pacientes consecutivos con EG tratados mediante TIR utilizando un metodo de calculo de dosis en nuestro hospital desde enero del 2015 hasta septiembre del 2015. La dosis de yodo radiactivo se calculo utilizando la formula de Marinelli. Se evaluaron la captacion de 99mTc-pertecnetato, edad, sexo, masa tiroidea, duracion de la enfermedad, tratamiento previo con antitiroideos, niveles sericos de TSH, FT3 Y FT4, tasa positiva de TPOAb y anti-TRAb, dosis de yodo radiactivo y seguimiento, como factores potenciales de interferencia para el exito de la TIR. Resultados El tratamiento fue exitoso en 108 pacientes con EG (77,7%), incluyendo 71 pacientes eutiroideos (51,1%) y 37 hipotiroideos (26,6%), aunque 31 pacientes (22,3%) siguieron siendo hipertiroideos (fracaso terapeutico). Encontramos diferencias significativas entre el grupo de tratamiento exitoso y el grupo de fracaso terapeutico en cuanto a captacion de 99mTc-pertecnetato (p Conclusion Nuestro estudio ha reflejado que el calculo de dosis de yodo radiactivo es eficaz para el tratamiento de los pacientes con EG, lo que redunda en una tasa baja de hipotiroidismo. Un porcentaje de captacion de 99mTc-pertecnetato superior al 18,4% constituye un factor predictivo significativo de fracaso terapeutico, por lo que los pacientes deberian recibir una dosis superior de yodo radiactivo en este caso. EnglishObjective The aim of this study was, first, to ascertain the efficacy of radioiodine therapy (RIT) for Graves’ disease (GD) based on a calculated-dose regime and, second, to determine the value of 99mTc-pertechnetate thyroid scintigraphy in predicting the clinical outcomes of RIT. Methods One hundred and thirty 9 consecutive GD patients who underwent RIT using a calculated-dose method in our hospital from January 2015 to September 2015 were retrospectively evaluated. Radioiodine dose was calculated based on the Marinelli's formula. 99mTc-pertechnetate uptake, age, gender, thyroid mass, duration of the disease, previous antithyroid drugs treatment, serum levels of TSH, FT3 and FT4, a positive rate of TPOAb and Anti-TRAb, radioiodine dose and follow-up were evaluated as potential interference factors for RIT success. Results One hundred and 8 (77.7%) GD patients including 71 (51.1%) euthyroid and 37 (26.6%) hypothyroid were successful, but 31 (22.3%) remained hyperthyroid (treatment failure). Significant differences were found between the treatment success group and the failure group in 99mTc-pertechnetate uptake (p Conclusion Our study has shown that a calculated radioiodine dose is effective in treating GD patients with a consequent low rate of hypothyroid. A 99mTc-pertechnetate uptake above 18.4% is a significant predictor of treatment failure and these patients should receive a higher radioiodine dose in this scenario.
Published: 2018
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9. Original Insights Into Rock Slope Damage Processes Until Collapse From Passive Seismic Monitoring

Author: P. Bottelin and L. Baillet
Subjects: passive seismic monitoring, unstable rock slope, rockfall, slope damaging, early warning system, Geophysics. Cosmic physics, QC801-809
Abstract: Abstract We performed a passive seismic monitoring of the La Praz ∼14,000 m3 unstable slope (French Alps) spanning over 10 years. During the last 6 months prior to collapse, we detected a clear 24% decrease in the slope's fundamental resonance frequency, f0, caused by a reduction in overall rock mass stiffness. The combined study of f0 and slope deformation suggested the alternating importance of sudden brittle failure processes versus more ductile phases with possible sliding. Seismic monitoring revealed slope damage that remained ambiguous or undetected with ground surface deformation monitoring, and highlighted critical periods with intense damage. Only some of these critical damage periods could be related to clear external forcing factors such as intense rainfall episodes. These new insights into rock slope's structural condition at depth represent an asset for future monitoring systems. Surface deformation and passive seismic stiffness tracking combined could reveal active slopes with ongoing damage processes.
Published: 2024
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10. Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID

Author: Omer Elneima, John R. Hurst, Carlos Echevarria, Jennifer K. Quint, Samantha Walker, Salman Siddiqui, Petr Novotny, Paul E. Pfeffer, Jeremy S. Brown, Manu Shankar-Hari, Hamish J.C. McAuley, Olivia C. Leavy, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Matthew Richardson, Ruth M. Saunders, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Ewen M. Harrison, Annemarie B. Docherty, Nazir I. Lone, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Rachael A. Evans, Louise V. Wain, Aziz Sheikh, Chris E. Brightling, Anthony De Soyza, Liam G. Heaney, J.K. Baillie, N.I. Lone, E. Pairo-Castineira, N. Avramidis, K. Rawlik, S Jones, L. Armstrong, B. Hairsine, H. Henson, C. Kurasz, A. Shaw, L. Shenton, H. Dobson, A. Dell, S. Fairbairn, N. Hawkings, J. Haworth, M. Hoare, V. Lewis, A. Lucey, G. Mallison, H. Nassa, C. Pennington, A. Price, C. Price, A. Storrie, G. Willis, S. Young, K. Poinasamy, S. Walker, I. Jarrold, A. Sanderson, K. Chong-James, C. David, W.Y. James, P. Pfeffer, O. Zongo, A. Martineau, C. Manisty, C. Armour, V. Brown, J. Busby, B. Connolly, T. Craig, S. Drain, L.G. Heaney, B. King, N. Magee, E. Major, D. McAulay, L. McGarvey, J. McGinness, T. Peto, R. Stone, A. Bolger, F. Davies, A. Haggar, J. Lewis, A. Lloyd, R. Manley, E. McIvor, D. Menzies, K. Roberts, W. Saxon, D. Southern, C. Subbe, V. Whitehead, A. Bularga, N.L. Mills, J. Dawson, H. El-Taweel, L. Robinson, L. Brear, K. Regan, D. Saralaya, K. Storton, S. Amoils, A. Bermperi, I. Cruz, K. Dempsey, A. Elmer, J. Fuld, H. Jones, S. Jose, S. Marciniak, M. Parkes, C. Ribeiro, J. Taylor, M. Toshner, L. Watson, J. Worsley, L. Broad, T. Evans, M. Haynes, L. Jones, L. Knibbs, A. McQueen, C. Oliver, K. Paradowski, R. Sabit, J. Williams, I. Jones, L. Milligan, E. Harris, C. Sampson, E. Davies, C. Evenden, A. Hancock, K. Hancock, C. Lynch, M. Rees, L. Roche, N. Stroud, T. Thomas-Woods, S. Heller, T. Chalder, K. Shah, E. Robertson, B. Young, M. Babores, M. Holland, N. Keenan, S. Shashaa, H. Wassall, L. Austin, E. Beranova, T. Cosier, J. Deery, T. Hazelton, H. Ramos, R. Solly, S. Turney, H. Weston, M. Ralser, L. Pearce, S. Pugmire, W. Stoker, A. Wilson, W. McCormick, E. Fraile, J. Ugoji, L. Aguilar Jimenez, G. Arbane, S. Betts, K. Bisnauthsing, A. Dewar, N. Hart, G. Kaltsakas, H. Kerslake, M.M. Magtoto, P. Marino, L.M. Martinez, M. Ostermann, J. Rossdale, T.S. Solano, M. Alvarez Corral, A. Arias, E. Bevan, D. Griffin, J. Martin, J. Owen, S. Payne, A. Prabhu, A. Reed, W. Storrar, N. Williams, C. Wrey Brown, T. Burdett, J. Featherstone, C. Lawson, A. Layton, C. Mills, L. Stephenson, Y. Ellis, P. Atkin, K. Brindle, M.G. Crooks, K. Drury, N. Easom, R. Flockton, L. Holdsworth, A. Richards, D.L. Sykes, S. Thackray-Nocera, C. Wright, S. Coetzee, K. Davies, R. Hughes, R. Loosley, H. McGuinness, A. Mohamed, L. O'Brien, Z. Omar, E. Perkins, J. Phipps, G. Ross, A. Taylor, H. Tench, R. Wolf-Roberts, L. Burden, E. Calvelo, B. Card, C. Carr, E.R. Chilvers, D. Copeland, P. Cullinan, P. Daly, L. Evison, T. Fayzan, H. Gordon, S. Haq, R.G. Jenkins, C. King, O. Kon, K. March, M. Mariveles, L. McLeavey, N. Mohamed, S. Moriera, U. Munawar, J. Nunag, U. Nwanguma, L. Orriss-Dib, A. Ross, M. Roy, E. Russell, K. Samuel, J. Schronce, N. Simpson, L. Tarusan, D.C. Thomas, C. Wood, N. Yasmin, D. Altmann, L.S. Howard, D. Johnston, A. Lingford-Hughes, W.D-C. Man, J. Mitchell, P.L. Molyneaux, C. Nicolaou, D.P. O'Regan, L. Price, J. Quint, D. Smith, R.S. Thwaites, J. Valabhji, S. Walsh, C.M. Efstathiou, F. Liew, A. Frankel, L. Lightstone, S. McAdoo, M. Wilkins, M. Willicombe, R. Touyz, A-M. Guerdette, M. Hewitt, R. Reddy, K. Warwick, S. White, A. McMahon, M. Malim, K. Bramham, M. Brown, K. Ismail, T. Nicholson, C. Pariante, C. Sharpe, S. Wessely, J. Whitney, O. Adeyemi, R. Adrego, H. Assefa-Kebede, J. Breeze, S. Byrne, P. Dulawan, A. Hoare, C.J. Jolley, A. Knighton, S. Patale, I. Peralta, N. Powell, A. Ramos, K. Shevket, F. Speranza, A. Te, A. Shah, A. Chiribiri, C. O'Brien, A. Hayday, A. Ashworth, P. Beirne, J. Clarke, C. Coupland, M. Dalton, C. Favager, J. Glossop, J. Greenwood, L. Hall, T. Hardy, A. Humphries, J. Murira, D. Peckham, S. Plein, J. Rangeley, G. Saalmink, A.L. Tan, E. Wade, B. Whittam, N. Window, J. Woods, G. Coakley, L. Turtle, L. Allerton, A.M. Allt, M. Beadsworth, A. Berridge, J. Brown, S. Cooper, A. Cross, S. Defres, S.L. Dobson, J. Earley, N. French, W. Greenhalf, K. Hainey, H.E. Hardwick, J. Hawkes, V. Highett, S. Kaprowska, A.L. Key, L. Lavelle-Langham, N. Lewis-Burke, G. Madzamba, F. Malein, S. Marsh, C. Mears, L. Melling, M.J. Noonan, L. Poll, J. Pratt, E. Richardson, A. Rowe, M.G. Semple, V. Shaw, K.A. Tripp, L.O. Wajero, S.A. Williams-Howard, D.G. Wootton, J. Wyles, S.N. Diwanji, S. Gurram, P. Papineni, S. Quaid, G.F. Tiongson, E. Watson, A. Briggs, M. Marks, C. Hastie, N. Rogers, N. Smith, D. Stensel, L. Bishop, K. McIvor, P. Rivera-Ortega, B. Al-Sheklly, C. Avram, J. Blaikely, M. Buch, N. Choudhury, D. Faluyi, T. Felton, T. Gorsuch, N.A. Hanley, A. Horsley, T. Hussell, Z. Kausar, N. Odell, R. Osbourne, K. Piper Hanley, K. Radhakrishnan, S. Stockdale, T. Kabir, J.T. Scott, P.J.M. Openshaw, I.D. Stewart, D. Burn, A. Ayoub, G. Burns, G. Davies, A. De Soyza, C. Echevarria, H. Fisher, C. Francis, A. Greenhalgh, P. Hogarth, J. Hughes, K. Jiwa, G. Jones, G. MacGowan, D. Price, A. Sayer, J. Simpson, H. Tedd, S. Thomas, S. West, M. Witham, S. Wright, A. Young, M.J. McMahon, P. Neill, D. Anderson, N. Basu, H. Bayes, A. Brown, A. Dougherty, K. Fallon, L. Gilmour, D. Grieve, K. Mangion, A. Morrow, R. Sykes, C. Berry, I.B. McInnes, K. Scott, F. Barrett, A. Donaldson, E.K. Sage, D. Bell, R. Hamil, K. Leitch, L. Macliver, M. Patel, J. Quigley, A. Smith, B. Welsh, G. Choudhury, S. Clohisey, A. Deans, A.B. Docherty, J. Furniss, E.M. Harrison, S. Kelly, A. Sheikh, J.D. Chalmers, D. Connell, C. Deas, A. Elliott, J. George, S. Mohammed, J. Rowland, A.R. Solstice, D. Sutherland, C.J. Tee, J. Bunker, R. Gill, R. Nathu, K. Holmes, H. Adamali, D. Arnold, S. Barratt, A. Dipper, S. Dunn, N. Maskell, A. Morley, L. Morrison, L. Stadon, S. Waterson, H. Welch, B. Jayaraman, T. Light, I. Vogiatzis, P. Almeida, C.E. Bolton, A. Hosseini, L. Matthews, R. Needham, K. Shaw, A.K. Thomas, J. Bonnington, M. Chrystal, C. Dupont, P.L. Greenhaff, A. Gupta, W. Jang, S. Linford, A. Nikolaidis, S. Prosper, A. Burns, N. Kanellakis, V.M. Ferreira, C. Nikolaidou, C. Xie, M. Ainsworth, A. Alamoudi, A. Bloss, P. Carter, M. Cassar, J. Chen, F. Conneh, T. Dong, R.I. Evans, E. Fraser, J.R. Geddes, F. Gleeson, P. Harrison, M. Havinden-Williams, L.P. Ho, P. Jezzard, I. Koychev, P. Kurupati, H. McShane, C. Megson, S. Neubauer, D. Nicoll, G. Ogg, E. Pacpaco, M. Pavlides, Y. Peng, N. Petousi, J. Pimm, N.M. Rahman, B. Raman, M.J. Rowland, K. Saunders, M. Sharpe, N. Talbot, E.M. Tunnicliffe, A. Korszun, S. Kerr, R.E. Barker, D. Cristiano, N. Dormand, P. George, M. Gummadi, S. Kon, K. Liyanage, C.M. Nolan, B. Patel, S. Patel, O. Polgar, P. Shah, S. Singh, J.A. Walsh, M. Gibbons, S. Ahmad, S. Brill, J. Hurst, H. Jarvis, L. Lim, S. Mandal, D. Matila, O. Olaosebikan, C. Singh, C. Laing, H. Baxendale, L. Garner, C. Johnson, J. Mackie, A. Michael, J. Newman, J. Pack, K. Paques, H. Parfrey, J. Parmar, A. Reddy, M. Halling-Brown, P. Dark, N. Diar-Bakerly, D. Evans, E. Hardy, A. Harvey, D. Holgate, S. Knight, N. Mairs, N. Majeed, L. McMorrow, J. Oxton, J. Pendlebury, C. Summersgill, R. Ugwuoke, S. Whittaker, W. Matimba-Mupaya, S. Strong-Sheldrake, P. Chowienczyk, J. Bagshaw, M. Begum, K. Birchall, R. Butcher, H. Carborn, F. Chan, K. Chapman, Y. Cheng, L. Chetham, C. Clark, Z. Coburn, J. Cole, M. Dixon, A. Fairman, J. Finnigan, H. Foot, D. Foote, A. Ford, R. Gregory, K. Harrington, L. Haslam, L. Hesselden, J. Hockridge, A. Holbourn, B. Holroyd-Hind, L. Holt, A. Howell, E. Hurditch, F. Ilyas, C. Jarman, A. Lawrie, J-H. Lee, E. Lee, R. Lenagh, A. Lye, I. Macharia, M. Marshall, A. Mbuyisa, J. McNeill, S. Megson, J. Meiring, L. Milner, S. Misra, H. Newell, T. Newman, C. Norman, L. Nwafor, D. Pattenadk, M. Plowright, J. Porter, P. Ravencroft, C. Roddis, J. Rodger, S.L. Rowland-Jones, P. Saunders, J. Sidebottom, J. Smith, L. Smith, N. Steele, G. Stephens, R. Stimpson, B. Thamu, A.A.R. Thompson, N. Tinker, K. Turner, H. Turton, P. Wade, J. Watson, I. Wilson, A. Zawia, L. Allsop, K. Bennett, P. Buckley, M. Flynn, M. Gill, C. Goodwin, M. Greatorex, H. Gregory, C. Heeley, L. Holloway, M. Holmes, J. Hutchinson, J. Kirk, W. Lovegrove, T.A. Sewell, S. Shelton, D. Sissons, K. Slack, S. Smith, D. Sowter, S. Turner, V. Whitworth, I. Wynter, J. Tomlinson, L. Warburton, S. Painter, S. Palmer, D. Redwood, J. Tilley, C. Vickers, T. Wainwright, G. Breen, M. Hotopf, R. Aul, D. Forton, M. Ali, A. Dunleavy, M. Mencias, N. Msimanga, T. Samakomva, S. Siddique, V. Tavoukjian, J. Teixeira, R. Ahmed, R. Francis, L. Connor, A. Cook, G.A. Davies, T. Rees, F. Thaivalappil, C. Thomas, M. McNarry, K.E. Lewis, M. Coulding, S. Kilroy, J. McCormick, J. McIntosh, V. Turner, J. Vere, A. Butt, H. Savill, S.S. Kon, G. Landers, H. Lota, S. Portukhay, M. Nasseri, A. Daniels, A. Hormis, J. Ingham, L. Zeidan, M. Chablani, L. Osborne, S. Aslani, A. Banerjee, R. Batterham, G. Baxter, R. Bell, A. David, E. Denneny, A.D. Hughes, W. Lilaonitkul, P. Mehta, A. Pakzad, B. Rangelov, B. Williams, J. Willoughby, M. Xu, N. Ahwireng, D. Bang, D. Basire, J.S. Brown, R.C. Chambers, A. Checkley, R. Evans, M. Heightman, T. Hillman, J. Jacob, R. Jastrub, M. Lipman, S. Logan, D. Lomas, M. Merida Morillas, H. Plant, J.C. Porter, K. Roy, E. Wall, T. Treibel, N. Ahmad Haider, C. Atkin, R. Baggott, M. Bates, A. Botkai, A. Casey, B. Cooper, J. Dasgin, C. Dawson, K. Draxlbauer, N. Gautam, J. Hazeldine, T. Hiwot, S. Holden, K. Isaacs, T. Jackson, V. Kamwa, D. Lewis, J.M. Lord, S. Madathil, C. McGhee, K. McGee, A. Neal, A. Newton-Cox, J. Nyaboko, D. Parekh, Z. Peterkin, H. Qureshi, L. Ratcliffe, E. Sapey, J. Short, T. Soulsby, J. Stockley, Z. Suleiman, T. Thompson, M. Ventura, S. Walder, C. Welch, D. Wilson, S. Yasmin, K.P. Yip, N. Chaudhuri, C. Childs, R. Djukanovic, S. Fletcher, M. Harvey, M.G. Jones, E. Marouzet, B. Marshall, R. Samuel, T. Sass, T. Wallis, H. Wheeler, R. Steeds, P. Beckett, C. Dickens, U. Nanda, M. Aljaroof, N. Armstrong, H. Arnold, H. Aung, M. Bakali, M. Bakau, E. Baldry, M. Baldwin, C. Bourne, M. Bourne, C.E. Brightling, N. Brunskill, P. Cairns, L. Carr, A. Charalambou, C. Christie, M.J. Davies, E. Daynes, S. Diver, R. Dowling, S. Edwards, C. Edwardson, O. Elneima, H. Evans, R.A. Evans, J. Finch, S. Finney, S. Glover, N. Goodman, B. Gooptu, N.J. Greening, K. Hadley, P. Haldar, B. Hargadon, V.C. Harris, L. Houchen-Wolloff, W. Ibrahim, L. Ingram, K. Khunti, A. Lea, D. Lee, H.J.C. McAuley, G.P. McCann, P. McCourt, T. McNally, G. Mills, W. Monteiro, M. Pareek, S. Parker, A. Prickett, I.N. Qureshi, A. Rowland, R. Russell, M. Sereno, A. Shikotra, S. Siddiqui, A. Singapuri, S.J. Singh, J. Skeemer, M. Soares, E. Stringer, S. Terry, T. Thornton, M. Tobin, T.J.C. Ward, F. Woodhead, T. Yates, A.J. Yousuf, B. Guillen Guiio, O.C. Leavy, L.V. Wain, M. Broome, P. McArdle, D. Thickett, R. Upthegrove, D. Wilkinson, P. Moss, D. Wraith, J. Evans, E. Bullmore, J.L. Heeney, C. Langenberg, W. Schwaeble, C. Summers, J. Weir McCall, D. Adeloye, D.E. Newby, R. Pius, I. Rudan, M. Shankar-Hari, C.L. Sudlow, M. Thorpe, S. Walmsley, B. Zheng, L. Allan, C. Ballard, A. McGovern, J. Dennis, J. Cavanagh, S. MacDonald, K. O'Donnell, J. Petrie, N. Sattar, M. Spears, E. Guthrie, M. Henderson, R.J. Allen, M. Bingham, T. Brugha, R. Free, D. Jones, L. Gardiner, A.J. Moss, E. Mukaetova-Ladinska, P. Novotny, C. Overton, J.E. Pearl, T. Plekhanova, M. Richardson, N. Samani, J. Sargent, M. Sharma, M. Steiner, C. Taylor, C. Tong, E. Turner, J. Wormleighton, B. Zhao, K. Ntotsis, R.M. Saunders, D. Lozano-Rojas, D. Cuthbertson, G. Kemp, A. McArdle, B. Michael, W. Reynolds, L.G. Spencer, B. Vinson, M. Ashworth, K. Abel, H. Chinoy, B. Deakin, M. Harvie, C.A. Miller, S. Stanel, P. Barran, D. Trivedi, H. McAllister-Williams, S. Paddick, A. Rostron, J.P. Taylor, D. Baguley, C. Coleman, E. Cox, L. Fabbri, S. Francis, I. Hall, E. Hufton, S. Johnson, F. Khan, P. Kitterick, R. Morriss, N. Selby, L. Wright, C. Antoniades, A. Bates, M. Beggs, K. Bhui, K. Breeze, K.M. Channon, D. Clark, X. Fu, M. Husain, X. Li, E. Lukaschuk, C. McCracken, K. McGlynn, R. Menke, K. Motohashi, T.E. Nichols, G. Ogbole, S. Piechnik, I. Propescu, J. Propescu, A.A. Samat, Z.B. Sanders, L. Sigfrid, M. Webster, L. Kingham, P. Klenerman, H. Lamlum, G. Carson, M. Taquet, L. Finnigan, L.C. Saunders, J.M. Wild, P.C. Calder, N. Huneke, G. Simons, D. Baldwin, S. Bain, L. Daines, E. Bright, P. Crisp, R. Dharmagunawardena, M. Stern, L. Bailey, A. Reddington, A. Wight, A. Ashish, J. Cooper, E. Robinson, A. Broadley, L. Barman, C. Brookes, K. Elliott, L. Griffiths, Z. Guy, K. Howard, D. Ionita, H. Redfearn, C. Sarginson, and A. Turnbull
Subjects: Medicine
Abstract: Background The long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown. Methods Adult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5 months and 1 year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (i.e., asthma, COPD or bronchiectasis) were compared to the non-airways group. Results A total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1 year, the airways group participants were less likely to feel fully recovered (20.4% versus 33.2%, p
Published: 2024
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11. A Comprehensive Seismic Monitoring of the Pillar Threatening the World Cultural Heritage Site Chauvet‐Pont d'Arc Cave, Toward Rock Damage Assessment

Author: A. Guillemot, L. Audin, É. Larose, L. Baillet, P. Guéguen, S. Jaillet, and J.‐J. Delannoy
Subjects: environmental seismology, rock column, resonance frequency, thermal forcings, acoustoelasticity, rock damage, Astronomy, QB1-991, Geology, QE1-996.5
Abstract: Abstract Fragile geological features must undergo frequent structural health assessments to prevent catastrophic failure events. The mechanical behavior of natural sites is largely guided by vibrations of the earth and environmental exposure, but damage is rarely assessed, except empirically. The Chauvet‐Pont d’Arc cave, a UNESCO World Heritage Site, represents a shining example of fragility that would benefit from monitoring. It is overhung by a rock column known as Abraham's pillar that extends out from the cliff like a natural tuning fork. For this study, we monitored dancing movements of this pillar for over 2 years to analyze its elastic response to weather conditions. Using ambient‐seismic‐noise‐based methods, we identified the pillar's first two natural resonance modes. Through extensive monitoring of the site, we observed the striking temporal evolution of these two resonance frequencies on hourly, daily, seasonal, and pluriannual scales in response to changes in air temperature and insolation. Based on thermo‐acousto‐elastic modeling with a simplified 3D geometric structure, we determined how thermally‐induced stress stiffening affects the rock material, by applying convective and radiative heat fluxes to the model. From the results obtained, we suggest a novel quantitative method based on daily observations that can estimate the level of damage within the rock material. Our work provides a foundation for distinguishing between reversible processes and damage for hazard studies in the frame of climate change. Such knowledge is crucial not only for the preservation of heritage sites but also for enhancing risk assessment protocols and informing conservation efforts worldwide.
Published: 2024
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12. Monitoring snow water equivalent using the phase of RFID signals

Author: M. Le Breton, É. Larose, L. Baillet, Y. Lejeune, and A. van Herwijnen
Subjects: Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract: The amount of water contained in a snowpack, known as snow water equivalent (SWE), is used to anticipate the amount of snowmelt that could supply hydroelectric power plants, fill water reservoirs, or sometimes cause flooding. This work introduces a wireless, non-destructive method for monitoring the SWE of a dry snowpack. The system is based on an array of low-cost passive radiofrequency identification (RFID) tags, placed under the snow and read at 865–868 MHz by a reader located above the snow. The SWE was deduced from the phase delay of the tag's backscattered response, which increases with the amount of snow traversed by the radiofrequency wave. Measurements taken in the laboratory, during snowfall events and over 4.5 months at the Col de Porte test field, were consistent with reference measurements of cosmic rays, precipitation and snow pits. SWE accuracy was ±18 kg m−2 throughout the season (averaged over three tags) and ±3 kg m−2 during dry snowfall events (averaged over data from two antennas and four or five tags). The overall uncertainty compared to snow weighing was ±10 % for snow density in the range 61–390 kg m−3. The main limitations observed were measurement bias caused by wet snow (biased data were discarded) and the need for phase unwrapping. The method has a number of advantages: it allows for continuous measurement (1 min sampling rate in dry snow), it can provide complementary measurement of tag temperature, it does not require the reception of external data, and it opens the way towards spatialized measurements. The results presented also demonstrate that RFID propagation-based sensing can remotely monitor the permittivity of a low-loss dielectric material with scientific-level accuracy.
Published: 2023
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13. Investigating Subglacial Water‐Filled Cavities by Spectral Analysis of Ambient Seismic Noise: Results on the Polythermal Tête‐Rousse Glacier (Mont Blanc, France)

Author: A. Guillemot, N. Bontemps, E. Larose, D. Teodor, S. Faller, L. Baillet, S. Garambois, E. Thibert, O. Gagliardini, and C. Vincent
Subjects: glaciers, instruments and techniques, V/H spectral ratio, ambient seismic noise, subglacial cavities, basal melting, Geophysics. Cosmic physics, QC801-809
Abstract: Abstract Polythermal glaciers can trap considerable volumes of liquid water with the potential to generate devastating outburst floods. This study aims to identify water‐filled subglacial reservoirs from ambient seismic noise collected by moderate‐cost surveys. The horizontal‐to‐vertical spectral ratio technique is highly sensitive to impedance contrasts at interfaces, thus commonly used to estimate glacier thickness. Here, we focus on the inverse ratio, that is, the V/H spectral ratio (VHSR), whose high values indicate a low impedance volume beneath the surface, suggesting subglacial cavities. We analyze VHSR peaks from a seismic array of 60 nodes installed on the Tête‐Rousse Glacier (Mont Blanc massif, French Alps); data were gathered over 15 days. Mapping the VHSR amplitude over the free surface reveals the main cavity locations and the basal areas affected by melting within the glacier. Results obtained in the field are supported by a conceptual model based on 3D finite‐element simulations.
Published: 2024
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14. (Meta)-Analysis of Safety and Efficacy Following Edge-to-Edge Mitral Valve Repair Using the MitraClip System

Author: Dorothee H. L. Bail
Subjects: Mitral regurgitation, Mitral valve repair, medicine.medical_specialty, business.industry, medicine.medical_treatment, MitraClip, MEDLINE, Nyha class, Surgery, law.invention, Randomized controlled trial, law, Meta-analysis, medicine, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, Adverse effect, business
Abstract: Objectives The authors investigated safety and efficacy of the MitraClip-System (MCS) using a systematic analysis. Background The safety and efficacy of the MCS continues to be debated, and randomized trials are still lacking. Method A systematic literature search was conducted using common medical and scientific databases. The following kinds of data were obtained: at baseline, 30 days, 6 and 12 month post-procedure. For safety and efficacy mortality-rate (survival), mitral regurgitation
Published: 2015
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15. First observation of the cosmic ray shadow of the Moon and the Sun with KM3NeT/ORCA

Author: S. Aiello, A. Albert, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, M. Anghinolfi, M. Anguita, M. Ardid, S. Ardid, J. Aublin, C. Bagatelas, L. Bailly-Salins, B. Baret, S. Basegmez du Pree, Y. Becherini, M. Bendahman, F. Benfenati, E. Berbee, V. Bertin, S. Biagi, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, M. Bouwhuis, C. Bozza, H. Brânzaş, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, D. Calvo, S. Campion, A. Capone, F. Carenini, V. Carretero, P. Castaldi, S. Celli, L. Cerisy, M. Chabab, N. Chau, A. Chen, R. Cherkaoui El Moursli, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, R. Coniglione, P. Coyle, A. Creusot, A. Cruz, G. Cuttone, R. Dallier, Y. Darras, A. De Benedittis, B. De Martino, R. Del Burgo, I. Di Palma, A. F. Dìaz, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, E. Drakopoulou, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, M. Eff, D. van Eijk, I. El Bojaddaini, S. El Hedri, A. Enzenhöfer, V. Espinosa, G. Ferrara, M. D. Filipović, F. Filippini, L. A. Fusco, J. Gabriel, T. Gal, J. García Méndez, A. Garcia Soto, F. Garufi, C. Gatius Oliver, N. Geißelbrecht, L. Gialanella, E. Giorgio, A. Girardi, I. Goos, S. R. Gozzini, R. Gracia, K. Graf, D. Guderian, C. Guidi, B. Guillon, M. Gutiérrez, L. Haegel, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J. J. Hernández-Rey, F. Huang, W. Idrissi Ibnsalih, G. Illuminati, C. W. James, D. Janezashvili, M. de Jong, P. de Jong, B. J. Jung, P. Kalaczyński, O. Kalekin, U. F. Katz, N. R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, V. Kulikovskiy, M. Labalme, R. Lahmann, A. Lakhal, M. Lamoureux, G. Larosa, C. Lastoria, A. Lazo, R. Le Breton, S. Le Stum, G. Lehaut, E. Leonora, N. Lessing, G. Levi, S. Liang, M. Lindsey Clark, F. Longhitano, L. Maderer, J. Majumdar, J. Mańczak, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J. A. Martínez-Mora, A. Martini, F. Marzaioli, M. Mastrodicasa, S. Mastroianni, K. W. Melis, S. Miccichè, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, C. M. Mollo, L. Morales-Gallegos, C. Morley-Wong, A. Moussa, R. Muller, M. R. Musone, M. Musumeci, L. Nauta, S. Navas, C. A. Nicolau, B. Nkosi, B. Ó. Fearraigh, A. Orlando, E. Oukacha, J. Palacios González, G. Papalashvili, R. Papaleo, E. J. Pastor Gomez, A. M. Păun, G. E. Păvălaş, C. Pellegrino, S. Peña Martínez, M. Perrin-Terrin, J. Perronnel, V. Pestel, P. Piattelli, O. Pisanti, C. Poirè, V. Popa, T. Pradier, S. Pulvirenti, G. Quéméner, U. Rahaman, N. Randazzo, S. Razzaque, I. C. Rea, D. Real, S. Reck, G. Riccobene, J. Robinson, A. Romanov, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, M. Sanguineti, C. Santonastaso, D. Santonocito, P. Sapienza, A. Sathe, J. Schnabel, M. F. Schneider, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, A. Simonelli, A. Sinopoulou, M. V. Smirnov, B. Spisso, M. Spurio, D. Stavropoulos, S. M. Stellacci, M. Taiuti, K. Tavzarashvili, Y. Tayalati, H. Tedjditi, H. Thiersen, S. Tsagkli, V. Tsourapis, E. Tzamariudaki, V. Van Elewyck, G. Vannoye, G. Vasileiadis, F. Versari, S. Viola, D. Vivolo, H. Warnhofer, J. Wilms, E. de Wolf, H. Yepes-Ramirez, T. Yousfi, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, and N. Zywucka
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract This article reports the first observation of the Moon and the Sun shadows in the sky distribution of cosmic-ray induced muons measured by the KM3NeT/ORCA detector. The analysed data-taking period spans from February 2020 to November 2021, when the detector had 6 Detection Units deployed at the bottom of the Mediterranean Sea, each composed of 18 Digital Optical Modules. The shadows induced by the Moon and the Sun were detected at their nominal position with a statistical significance of 4.2 $$\sigma $$ σ and 6.2 $$\sigma $$ σ , and an angular resolution of $$\sigma _{res}=0.49^\circ $$ σ res = 0 . 49 ∘ and $$\sigma _{res}=0.66^\circ $$ σ res = 0 . 66 ∘ , respectively, consistent with the prediction of $$0.53^\circ $$ 0 . 53 ∘ from simulations. This early result confirms the effectiveness of the detector calibration, in time, position and orientation and the accuracy of the event direction reconstruction. This also demonstrates the performance and the competitiveness of the detector in terms of pointing accuracy and angular resolution.
Published: 2023
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16. Probing invisible neutrino decay with KM3NeT/ORCA

Author: The KM3NeT collaboration, S. Aiello, A. Albert, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, M. Anghinolfi, M. Anguita, M. Ardid, S. Ardid, J. Aublin, C. Bagatelas, L. Bailly-Salins, B. Baret, S. Basegmez du Pree, Y. Becherini, M. Bendahman, F. Benfenati, E. Berbee, V. Bertin, S. Biagi, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, M. Bouwhuis, C. Bozza, H. Brânzaş, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, D. Calvo, S. Campion, A. Capone, F. Carenini, V. Carretero, P. Castaldi, S. Celli, L. Cerisy, M. Chabab, N. Chau, A. Chen, R. Cherkaoui El Moursli, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, R. Coniglione, P. Coyle, A. Creusot, A. Cruz, G. Cuttone, R. Dallier, Y. Darras, A. De Benedittis, B. De Martino, V. Decoene, R. Del Burgo, I. Di Palma, A. F. Díaz, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, E. Drakopoulou, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, M. Eff, D. van Eijk, I. El Bojaddaini, S. El Hedri, A. Enzenhöfer, V. Espinosa, G. Ferrara, M. D. Filipović, F. Filippini, L. A. Fusco, J. Gabriel, T. Gal, J. García Méndez, A. Garcia Soto, F. Garufi, C. Gatius Oliver, N. Geißelbrecht, L. Gialanella, E. Giorgio, A. Girardi, I. Goos, S. R. Gozzini, R. Gracia, K. Graf, D. Guderian, C. Guidi, B. Guillon, M. Gutiérrez, L. Haegel, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J. J. Hernández-Rey, F. Huang, W. Idrissi Ibnsalih, G. Illuminati, C. W. James, D. Janezashvili, M. de Jong, P. de Jong, B. J. Jung, P. Kalaczyński, O. Kalekin, U. F. Katz, N. R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, V. Kulikovskiy, M. Labalme, R. Lahmann, A. Lakhal, M. Lamoureux, G. Larosa, C. Lastoria, A. Lazo, R. Le Breton, S. Le Stum, G. Lehaut, E. Leonora, N. Lessing, G. Levi, S. Liang, M. Lindsey Clark, F. Longhitano, L. Maderer, J. Majumdar, J. Mańczak, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J. A. Martínez-Mora, A. Martini, F. Marzaioli, M. Mastrodicasa, S. Mastroianni, K. W. Melis, S. Miccichè, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, C. M. Mollo, L. Morales-Gallegos, C. Morley-Wong, A. Moussa, R. Muller, M. R. Musone, M. Musumeci, L. Nauta, S. Navas, C. A. Nicolau, B. Nkosi, B. Ó Fearraigh, A. Orlando, E. Oukacha, J. Palacios González, G. Papalashvili, R. Papaleo, E. J. Pastor Gomez, A. M. Păun, G. E. Păvălaş, C. Pellegrino, S. Peña Martínez, M. Perrin-Terrin, J. Perronnel, V. Pestel, P. Piattelli, O. Pisanti, C. Poirè, V. Popa, T. Pradier, S. Pulvirenti, G. Quéméner, U. Rahaman, N. Randazzo, S. Razzaque, I. C. Rea, D. Real, S. Reck, G. Riccobene, J. Robinson, A. Romanov, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, M. Sanguineti, C. Santonastaso, D. Santonocito, P. Sapienza, A. Sathe, J. Schnabel, M. F. Schneider, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, A. Simonelli, A. Sinopoulou, M. V. Smirnov, B. Spisso, M. Spurio, D. Stavropoulos, S. M. Stellacci, M. Taiuti, K. Tavzarashvili, Y. Tayalati, H. Tedjditi, T. Thakore, H. Thiersen, S. Tsagkli, V. Tsourapis, E. Tzamariudaki, V. Van Elewyck, G. Vannoye, G. Vasileiadis, F. Versari, S. Viola, D. Vivolo, H. Warnhofer, J. Wilms, E. de Wolf, H. Yepes-Ramirez, T. Yousfi, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, and N. Zywucka
Subjects: Beyond Standard Model, Neutrino Detectors and Telescopes (experiments), Oscillation, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract In the era of precision measurements of the neutrino oscillation parameters, upcoming neutrino experiments will also be sensitive to physics beyond the Standard Model. KM3NeT/ORCA is a neutrino detector optimised for measuring atmospheric neutrinos from a few GeV to around 100 GeV. In this paper, the sensitivity of the KM3NeT/ORCA detector to neutrino decay has been explored. A three-flavour neutrino oscillation scenario, where the third neutrino mass state ν 3 decays into an invisible state, e.g. a sterile neutrino, is considered. We find that KM3NeT/ORCA would be sensitive to invisible neutrino decays with 1/α 3 = τ 3 /m 3 < 180 ps/eV at 90% confidence level, assuming true normal ordering. Finally, the impact of neutrino decay on the precision of KM3NeT/ORCA measurements for θ 23, Δ m 31 2 $$ \Delta {m}_{31}^2 $$ and mass ordering have been studied. No significant effect of neutrino decay on the sensitivity to these measurements has been found.
Published: 2023
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17. Fatigue mechanisms of a closed cell elastomeric foam: A mechanical and microstructural study using ex situ X-ray microtomography

Author: C. Aimar, L. Orgéas, S. Rolland du Roscoat, L. Bailly, and D. Ferré Sentis
Subjects: Closed cell elastomeric foams, Fatigue, Compression test, Damage mechanisms, X-ray microtomography, Memory effects, Polymers and polymer manufacture, TP1080-1185
Abstract: The degradation of mechanical properties of closed-cell elastomeric foams in fatigue and its link with the cellular structure is still poorly understood. To clarify this, we performed interrupted and continuous cyclic compression tests on EVA closed-cell foams used in running shoes. The 3D cellular structures of tested samples was analyzed before, during and after fatigue tests using X-ray microtomography and digital volume correlation. Interrupting the cycling allows the observation of the cell flattening along the compression axis with both plastic bending and an increase of tears/holes of cell walls. These two fatigue-induced defects are suspected to play a strong contribution on the fatigue properties of the foam at the sample scale and may explain the partial recovery of the initial mechanical property of foams while restarting cycling.
Published: 2023
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18. Treatment of functional mitral regurgitation by percutaneous annuloplasty using the Carillon Mitral Contour System-Currently available data state

Author: Dorothee H. L. Bail
Subjects: Male, medicine.medical_specialty, Percutaneous, Mitral Valve Annuloplasty, 030204 cardiovascular system & hematology, Effective Regurgitant Orifice Area, law.invention, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Randomized controlled trial, law, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Functional mitral regurgitation, Mitral Annuloplasty, Aged, Mitral regurgitation, Vena contracta, business.industry, Mitral Valve Insufficiency, Middle Aged, Surgery, Treatment Outcome, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Objective The purpose of this study is to provide a systematic review of currently available data about the percutaneous trans-coronary-venous mitral annuloplasty with the Carillon Mitral Contour System. Method A systematic literature search was conducted using the common medical and scientific databases. The documented parameters included among others grade of mitral regurgitation (MR), vena contracta (VC), effective regurgitant orifice area (EROA), 6 minute-walk-test (6MWT), NYHA-classification, and Quality of Life (QoL) at baseline, 30 days and in the long-term follow-up. Results The exact total number of successfully implantations with available data remains unclear because so many publications are either of the same institution or study group, or they present overlapping results. Reduction of functional mitral regurgitation (FMR) was associated with significant inverse left-ventricular (LV)) remodeling, improvement in 6MWT, QoL and NYHA-class during the 12-month follow-up. In almost half of the enrolled patients, the Carillon System could not be implanted or had to be removed due to coronary compromission. Adverse advent rate (AE) ranged between 2.8–39%. Conclusions Results with regard to reduction of MR and inverse LV remodeling have been remarkable. Indication and selection criteria for suitable patients, the expected complications, and the long-term results with regard to survival and quality of life still remain unclear. The available results do not establish superiority of the Carillon Mitral Contour System and support the lack of a clear benefit. The approach with the Carillon Mitral Contour System should be limited to participants of prospective and randomized trials.
Published: 2016

19. A notched coupon approach for tensile testing of braided composites

Author: Jonathan A. Salem, Wieslaw K. Binienda, Justin L. Bail, Gary D. Roberts, Lee W. Kohlman, and Richard E. Martin
Subjects: Transverse plane, Materials science, Mechanics of Materials, Tension (physics), Ultimate tensile strength, Ceramics and Composites, Braid, Biaxial tensile test, Composite material, Edge (geometry), Tensile testing, Stress concentration
Abstract: A notched coupon geometry was evaluated as a method for tensile testing of 2D triaxial braid composites. Edge initiated shear failure has been observed in transverse tension tests using straight-sided coupons based on ASTM D3039. The notched coupon was designed to reduce the effects of edge initiated failure and produce the desired tensile failure. A limited set of tests were performed with partial pressurization of tubes to determine the transverse tensile strength in the absence of edge initiated failure. The transverse strength measured with the notched coupons was considerably higher than the straight-sided coupons, comparable to the tube results, and closer to the maximum possible strength based on maximum fiber strain. Further investigations of the effects of the observed biaxial stress state and stress concentrations in the notched geometry are needed.
Published: 2012
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20. Effects of hygrothermal cycling on the chemical, thermal, and mechanical properties of 862/W epoxy resin

Author: Sandi G. Miller, Wieslaw K. Binienda, Gary D. Roberts, Justin L. Bail, and Lee W. Kohlman
Subjects: Materials science, Polymers and Plastics, Organic Chemistry, Epoxy, Dynamic mechanical analysis, Brittleness, Differential scanning calorimetry, visual_art, Ultimate tensile strength, Materials Chemistry, visual_art.visual_art_medium, Composite material, Ductility, Embrittlement, Chemical decomposition
Abstract: The hygrothermal aging characteristics of an epoxy resin were characterized over 1 year, which included 908 temperature and humidity cycles. The epoxy resin quickly showed evidence of aging through color change and increased brittleness. The influence of aging on the material s glass transition temperature (Tg) was evaluated by Differential Scanning Calorimetry (DSC) and Dynamic Mechanical Analysis (DMA). The Tg remained relatively constant throughout the year long cyclic aging profile. The chemical composition was monitored by Fourier Transform Infrared Spectroscopy (FTIR) where evidence of chemical aging and advancement of cure was noted. The tensile strength of the resin was tested as it aged. This property was severely affected by the aging process in the form of reduced ductility and embrittlement. Detailed chemical evaluation suggests many aging mechanisms are taking place during exposure to hygrothermal conditions. This paper details the influence of processes such as: advancement of cure, chemical degradation, and physical aging on the chemical and physical properties of the epoxy resin.
Published: 2012
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21. Das Entrapment-Syndrom der Arteria poplitea bei einem älteren Patienten: Diagnose nach erfolgloser laserassistierter perkutaner transluminaler Angioplastie

Author: W. Schneider, S. Duda, and D. H. L. Bail
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, General Medicine, Digital subtraction angiography, medicine.disease, Popliteal artery, Surgery, body regions, Gastrocnemius muscle, Stenosis, medicine.anatomical_structure, Oscillography, medicine.artery, Internal medicine, Angiography, medicine, Cardiology, Ankle, business, Artery
Abstract: HISTORY AND FINDINGS A 52-year-old patient complained of progressively increasing pain in his left leg when walking. The pain-free walking distance was 50-100 m. He was smoking about 20 cigarettes daily. No pulses were palpable in the left leg below the inguinal fossa. Recapillarisation time was normal in both legs and there were no trophic changes. INVESTIGATIONS The Doppler perfusion pressure values were up to 40 mm Hg less in the left than the right leg. Ankle oscillography record showed a definite stenosis curve on the left. Digital subtraction angiography of the left leg showed a short occlusion of the popliteal artery with many collaterals and atypical medical deviation of the artery. The findings were interpreted as indicating peripheral arterial vascular disease. TREATMENT AND COURSE Laser-assisted percutaneous transluminal angioplasty with balloon dilatation merely achieved a narrow lumen which again closed on plantar flexion of the left foot. The reversible occlusion suggested popliteal artery entrapment. At operation the popliteal artery coursed atypically over the dorsal medial aspect of the medial head of the gastrocnemius muscle. The arterial segment in the stenotic area was replaced by an autologous venous graft and the gastrocnemius muscle fixed laterally. The patients no longer experienced any impairment on walking and repeat angiography showed unimpeded flow through the graft even on plantar flexion. CONCLUSION Popliteal artery entrapment is rare in the elderly and may be overlooked without provocation test and complete visualisation of the leg and pelvic arteries.
Published: 2008
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22. Brain Natriuretic Peptide (BNP) in Patients Undergoing Coronary Artery Bypass Grafting

Author: M. Kofler, D. H. L. Bail, and G. Ziemer
Subjects: Male, Pulmonary and Respiratory Medicine, Inotrope, medicine.medical_specialty, Hemodynamics, Ventricular Function, Left, Coronary artery disease, Internal medicine, Natriuretic Peptide, Brain, medicine, Humans, Postoperative Period, cardiovascular diseases, Coronary Artery Bypass, Aged, business.industry, Extracorporeal circulation, Perioperative, Middle Aged, Brain natriuretic peptide, medicine.disease, medicine.anatomical_structure, Heart failure, cardiovascular system, Cardiology, Female, Surgery, Cardiology and Cardiovascular Medicine, business, human activities, hormones, hormone substitutes, and hormone antagonists, Artery
Abstract: BACKGROUND: This study was designed to examine plasma concentrations of BNP and its relation to hemodynamic parameters in patients (pts.) with coronary artery disease (CAD) undergoing coronary artery bypass grafting (CABG). METHODS: 21 pts. with CAD undergoing CABG were examined. The pts. were divided into two groups. Group I: normal left ventricular function (LVF); Group II: reduced LVF. Pre-, intra- and postoperative BNP and hemodynamic parameters were measured. The perioperative administration of inotropic drugs was documented. RESULTS: In both groups postoperative BNP increased to a peak 24 h postoperatively; although BNP concentrations were high 24 h postoperatively hemodynamic parameters were improved in both groups. In Group I the BNP peak did not correlate with any hemodynamic parameter nor with the use of inotropic drugs. In Group II the BNP peak was inversely correlated with CO and CI and positively correlated with the PCWP. There was no correlation with inotropic support. CONCLUSION: Postoperative peak of BNP after 24 h does not reflect a state of acute perioperative heart failure or myocardial damage. These results suggest that the gene expression, metabolism and biological activity of BNP may be altered after extracorporeal circulation. Further studies are warranted to reveal the actual triggers for BNP increase early after CABG.
Published: 2004
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23. Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort studyResearch in context

Author: Hamish J.C. McAuley, Rachael A. Evans, Charlotte E. Bolton, Christopher E. Brightling, James D. Chalmers, Annemarie B. Docherty, Omer Elneima, Paul L. Greenhaff, Ayushman Gupta, Victoria C. Harris, Ewen M. Harrison, Ling-Pei Ho, Alex Horsley, Linzy Houchen-Wolloff, Caroline J. Jolley, Olivia C. Leavy, Nazir I. Lone, William D-C Man, Michael Marks, Dhruv Parekh, Krisnah Poinasamy, Jennifer K. Quint, Betty Raman, Matthew Richardson, Ruth M. Saunders, Marco Sereno, Aarti Shikotra, Amisha Singapuri, Sally J. Singh, Michael Steiner, Ai Lyn Tan, Louise V. Wain, Carly Welch, Julie Whitney, Miles D. Witham, Janet Lord, Neil J. Greening, K. Abel, H. Adamali, D. Adeloye, O. Adeyemi, R. Adrego, L.A. Aguilar Jimenez, S. Ahmad, N. Ahmad Haider, R. Ahmed, N. Ahwireng, M. Ainsworth, B. Al-Sheklly, A. Alamoudi, M. Ali, M. Aljaroof, A.M. All, L. Allan, R.J. Allen, L. Allerton, L. Allsop, P. Almeida, D. Altmann, M. Alvarez Corral, S. Amoils, D. Anderson, C. Antoniades, G. Arbane, A. Arias, C. Armour, L. Armstrong, N. Armstrong, D. Arnold, H. Arnold, A. Ashish, A. Ashworth, M. Ashworth, S. Aslani, H. Assefa-Kebede, C. Atkin, P. Atkin, R. Aul, H. Aung, L. Austin, C. Avram, A. Ayoub, M. Babores, R. Baggott, J. Bagshaw, D. Baguley, L. Bailey, J.K. Baillie, S. Bain, M. Bakali, M. Bakau, E. Baldry, D. Baldwin, M. Baldwin, C. Ballard, A. Banerjee, B. Bang, R.E. Barker, L. Barman, S. Barratt, F. Barrett, D. Basire, N. Basu, M. Bates, A. Bates, R. Batterham, H. Baxendale, H. Bayes, M. Beadsworth, P. Beckett, M. Beggs, M. Begum, P. Beirne, D. Bell, R. Bell, K. Bennett, E. Beranova, A. Bermperi, A. Berridge, C. Berry, S. Betts, E. Bevan, K. Bhui, M. Bingham, K. Birchall, L. Bishop, K. Bisnauthsing, J. Blaikely, A. Bloss, A. Bolger, C.E. Bolton, J. Bonnington, A. Botkai, C. Bourne, M. Bourne, K. Bramham, L. Brear, G. Breen, J. Breeze, A. Briggs, E. Bright, C.E. Brightling, S. Brill, K. Brindle, L. Broad, A. Broadley, C. Brookes, M. Broome, A. Brown, J. Brown, J.S. Brown, M. Brown, V. Brown, T. Brugha, N. Brunskill, M. Buch, P. Buckley, A. Bularga, E. Bullmore, L. Burden, T. Burdett, D. Burn, G. Burns, A. Burns, J. Busby, R. Butcher, A. Butt, S. Byrne, P. Cairns, P.C. Calder, E. Calvelo, H. Carborn, B. Card, C. Carr, L. Carr, G. Carson, P. Carter, A. Casey, M. Cassar, J. Cavanagh, M. Chablani, T. Chalder, J.D. Chalmers, R.C. Chambers, F. Chan, K.M. Channon, K. Chapman, A. Charalambou, N. Chaudhuri, A. Checkley, J. Chen, Y. Cheng, L. Chetham, C. Childs, E.R. Chilvers, H. Chinoy, A. Chiribiri, K. Chong-James, G. Choudhury, N. Choudhury, P. Chowienczyk, C. Christie, M. Chrystal, D. Clark, C. Clark, J. Clarke, S. Clohisey, G. Coakley, Z. Coburn, S. Coetzee, J. Cole, C. Coleman, F. Conneh, D. Connell, B. Connolly, L. Connor, A. Cook, B. Cooper, J. Cooper, S. Cooper, D. Copeland, T. Cosier, M. Coulding, C. Coupland, E. Cox, T. Craig, P. Crisp, D. Cristiano, M.G. Crooks, A. Cross, I. Cruz, P. Cullinan, D. Cuthbertson, L. Daines, M. Dalton, P. Daly, A. Daniels, P. Dark, J. Dasgin, A. David, C. David, E. Davies, F. Davies, G. Davies, G.A. Davies, K. Davies, M.J. Davies, J. Dawson, E. Daynes, A. De Soyza, B. Deakin, A. Deans, C. Deas, J. Deery, S. Defres, A. Dell, K. Dempsey, E. Denneny, J. Dennis, A. Dewar, R. Dharmagunawardena, N. Diar-Bakerly, C. Dickens, A. Dipper, S. Diver, S.N. Diwanji, M. Dixon, R. Djukanovic, H. Dobson, S.L. Dobson, A.B. Docherty, A. Donaldson, T. Dong, N. Dormand, A. Dougherty, R. Dowling, S. Drain, K. Draxlbauer, K. Drury, H.J.C. Drury, P. Dulawan, A. Dunleavy, S. Dunn, C. Dupont, J. Earley, N. Easom, C. Echevarria, S. Edwards, C. Edwardson, H. El-Taweel, A. Elliott, K. Elliott, Y. Ellis, A. Elmer, O. Elneima, D. Evans, H. Evans, J. Evans, R. Evans, R.A. Evans, R.I. Evans, T. Evans, C. Evenden, L. Evison, L. Fabbri, S. Fairbairn, A. Fairman, K. Fallon, D. Faluyi, C. Favager, T. Fayzan, J. Featherstone, T. Felton, J. Finch, S. Finney, J. Finnigan, L. Finnigan, H. Fisher, S. Fletcher, R. Flockton, M. Flynn, H. Foot, D. Foote, A. Ford, D. Forton, E. Fraile, C. Francis, R. Francis, S. Francis, A. Frankel, E. Fraser, R. Free, N. French, X. Fu, J. Fuld, J. Furniss, L. Garner, N. Gautam, J.R. Geddes, J. George, P. George, M. Gibbons, M. Gill, L. Gilmour, F. Gleeson, J. Glossop, S. Glover, N. Goodman, C. Goodwin, B. Gooptu, H. Gordon, T. Gorsuch, M. Greatorex, P.L. Greenhaff, W. Greenhalf, A. Greenhalgh, N.J. Greening, J. Greenwood, H. Gregory, R. Gregory, D. Grieve, D. Griffin, L. Griffiths, A.-M. Guerdette, B. Guillen Guio, M. Gummadi, A. Gupta, S. Gurram, E. Guthrie, Z. Guy, H.H. Henson, K. Hadley, A. Haggar, K. Hainey, B. Hairsine, P. Haldar, I. Hall, L. Hall, M. Halling-Brown, R. Hamil, A. Hancock, K. Hancock, N.A. Hanley, S. Haq, H.E. Hardwick, E. Hardy, T. Hardy, B. Hargadon, K. Harrington, E. Harris, V.C. Harris, E.M. Harrison, P. Harrison, N. Hart, A. Harvey, M. Harvey, M. Harvie, L. Haslam, M. Havinden-Williams, J. Hawkes, N. Hawkings, J. Haworth, A. Hayday, M. Haynes, J. Hazeldine, T. Hazelton, L.G. Heaney, C. Heeley, J.L. Heeney, M. Heightman, S. Heller, M. Henderson, L. Hesselden, M. Hewitt, V. Highett, T. Hillman, T. Hiwot, L.P. Ho, A. Hoare, M. Hoare, J. Hockridge, P. Hogarth, A. Holbourn, S. Holden, L. Holdsworth, D. Holgate, M. Holland, L. Holloway, K. Holmes, M. Holmes, B. Holroyd-Hind, L. Holt, A. Hormis, A. Horsley, A. Hosseini, M. Hotopf, L. Houchen-Wolloff, K. Howard, L.S. Howard, A. Howell, E. Hufton, A.D. Hughes, J. Hughes, R. Hughes, A. Humphries, N. Huneke, E. Hurditch, J. Hurst, M. Husain, T. Hussell, J. Hutchinson, W. Ibrahim, F. Ilyas, J. Ingham, L. Ingram, D. Ionita, K. Isaacs, K. Ismail, T. Jackson, J. Jacob, W.Y. James, W. Jang, C. Jarman, I. Jarrold, H. Jarvis, R. Jastrub, B. Jayaraman, R.G. Jenkins, P. Jezzard, K. Jiwa, C. Johnson, S. Johnson, D. Johnston, C.J. Jolley, D. Jones, G. Jones, H. Jones, I. Jones, L. Jones, M.G. Jones, S. Jones, S. Jose, T. Kabir, G. Kaltsakas, V. Kamwa, N. Kanellakis, S. Kaprowska, Z. Kausar, N. Keenan, S. Kelly, G. Kemp, S. Kerr, H. Kerslake, A.L. Key, F. Khan, K. Khunti, S. Kilroy, B. King, C. King, L. Kingham, J. Kirk, P. Kitterick, P. Klenerman, L. Knibbs, S. Knight, A. Knighton, O. Kon, S. Kon, S.S. Kon, S. Koprowska, A. Korszun, I. Koychev, C. Kurasz, P. Kurupati, C. Laing, H. Lamlum, G. Landers, C. Langenberg, D. Lasserson, L. Lavelle-Langham, A. Lawrie, C. Lawson, A. Layton, A. Lea, O.C. Leavy, D. Lee, J.-H. Lee, E. Lee, K. Leitch, R. Lenagh, D. Lewis, J. Lewis, K.E. Lewis, V. Lewis, N. Lewis-Burke, X. Li, T. Light, L. Lightstone, W. Lilaonitkul, L. Lim, S. Linford, A. Lingford-Hughes, M. Lipman, K. Liyanage, A. Lloyd, S. Logan, D. Lomas, N.I. Lone, R. Loosley, J.M. Lord, H. Lota, W. Lovegrove, A. Lucey, E. Lukaschuk, A. Lye, C. Lynch, S. MacDonald, G. MacGowan, I. Macharia, J. Mackie, L. Macliver, S. Madathil, G. Madzamba, N. Magee, M.M. Magtoto, N. Mairs, N. Majeed, E. Major, F. Malein, M. Malim, G. Mallison, W. D-C Man, S. Mandal, K. Mangion, C. Manisty, R. Manley, K. March, S. Marciniak, P. Marino, M. Mariveles, M. Marks, E. Marouzet, S. Marsh, B. Marshall, M. Marshall, J. Martin, A. Martineau, L.M. Martinez, N. Maskell, D. Matila, W. Matimba-Mupaya, L. Matthews, A. Mbuyisa, S. McAdoo, H. McAllister-Williams, A. McArdle, P. McArdle, D. McAulay, G.P. McCann, J. McCormick, W. McCormick, P. McCourt, L. McGarvey, C. McGee, K. Mcgee, J. McGinness, K. McGlynn, A. McGovern, H. McGuinness, I.B. McInnes, J. McIntosh, E. McIvor, K. McIvor, L. McLeavey, A. McMahon, M.J. McMahon, L. McMorrow, T. Mcnally, M. McNarry, J. McNeill, A. McQueen, H. McShane, C. Mears, C. Megson, S. Megson, P. Mehta, J. Meiring, L. Melling, M. Mencias, D. Menzies, M. Merida Morillas, A. Michael, C. Miller, L. Milligan, C. Mills, G. Mills, N.L. Mills, L. Milner, S. Misra, J. Mitchell, A. Mohamed, N. Mohamed, S. Mohammed, P.L. Molyneaux, W. Monteiro, S. Moriera, A. Morley, L. Morrison, R. Morriss, A. Morrow, A.J. Moss, P. Moss, K. Motohashi, N. Msimanga, E. Mukaetova-Ladinska, U. Munawar, J. Murira, U. Nanda, H. Nassa, M. Nasseri, A. Neal, R. Needham, P. Neill, S. Neubauer, D.E. Newby, H. Newell, T. Newman, J. Newman, A. Newton-Cox, T. Nicholson, D. Nicoll, A. Nikolaidis, C.M. Nolan, M.J. Noonan, C. Norman, P. Novotny, J. Nunag, L. Nwafor, U. Nwanguma, J. Nyaboko, C. O'Brien, K. O'Donnell, D. O'Regan, L. O’Brien, N. Odell, G. Ogg, O. Olaosebikan, C. Oliver, Z. Omar, P.J.M. Openshaw, L. Orriss-Dib, L. Osborne, R. Osbourne, M. Ostermann, C. Overton, J. Owen, J. Oxton, J. Pack, E. Pacpaco, S. Paddick, S. Painter, A. Pakzad, S. Palmer, P. Papineni, K. Paques, K. Paradowski, M. Pareek, D. Parekh, H. Parfrey, C. Pariante, S. Parker, M. Parkes, J. Parmar, S. Patale, B. Patel, M. Patel, S. Patel, D. Pattenadk, M. Pavlides, S. Payne, L. Pearce, J.E. Pearl, D. Peckham, J. Pendlebury, Y. Peng, C. Pennington, I. Peralta, E. Perkins, Z. Peterkin, T. Peto, N. Petousi, J. Petrie, P. Pfeffer, J. Phipps, J. Pimm, K. Piper Hanley, R. Pius, H. Plant, S. Plein, T. Plekhanova, M. Plowright, K. Poinasamy, O. Polgar, L. Poll, J.C. Porter, J. Porter, S. Portukhay, N. Powell, A. Prabhu, J. Pratt, A. Price, C. Price, D. Price, L. Price, A. Prickett, J. Propescu, S. Prosper, S. Pugmire, S. Quaid, J. Quigley, J. Quint, H. Qureshi, I.N. Qureshi, K. Radhakrishnan, N.M. Rahman, M. Ralser, B. Raman, A. Ramos, H. Ramos, J. Rangeley, B. Rangelov, L. Ratcliffe, P. Ravencroft, A. Reddington, R. Reddy, A. Reddy, H. Redfearn, D. Redwood, A. Reed, M. Rees, T. Rees, K. Regan, W. Reynolds, C. Ribeiro, A. Richards, E. Richardson, M. Richardson, P. Rivera-Ortega, K. Roberts, E. Robertson, E. Robinson, L. Robinson, L. Roche, C. Roddis, J. Rodger, A. Ross, G. Ross, J. Rossdale, A. Rostron, A. Rowe, A. Rowland, J. Rowland, M.J. Rowland, S.L. Rowland-Jones, K. Roy, M. Roy, I. Rudan, R. Russell, E. Russell, G. Saalmink, R. Sabit, E.K. Sage, T. Samakomva, N. Samani, C. Sampson, K. Samuel, R. Samuel, A. Sanderson, E. Sapey, D. Saralaya, J. Sargant, C. Sarginson, T. Sass, N. Sattar, K. Saunders, R.M. Saunders, P. Saunders, L.C. Saunders, H. Savill, W. Saxon, A. Sayer, J. Schronce, W. Schwaeble, J.T. Scott, K. Scott, N. Selby, M.G. Semple, M. Sereno, T.A. Sewell, A. Shah, K. Shah, P. Shah, M. Shankar-Hari, M. Sharma, C. Sharpe, M. Sharpe, S. Shashaa, A. Shaw, K. Shaw, V. Shaw, A. Sheikh, S. Shelton, L. Shenton, K. Shevket, A. Shikotra, J. Short, S. Siddique, S. Siddiqui, J. Sidebottom, L. Sigfrid, G. Simons, J. Simpson, N. Simpson, A. Singapuri, C. Singh, S. Singh, S.J. Singh, D. Sissons, J. Skeemer, K. Slack, A. Smith, D. Smith, S. Smith, J. Smith, L. Smith, M. Soares, T.S. Solano, R. Solly, A.R. Solstice, T. Soulsby, D. Southern, D. Sowter, M. Spears, L.G. Spencer, F. Speranza, L. Stadon, S. Stanel, N. Steele, M. Steiner, D. Stensel, G. Stephens, L. Stephenson, M. Stern, I. Stewart, R. Stimpson, S. Stockdale, J. Stockley, W. Stoker, R. Stone, W. Storrar, A. Storrie, K. Storton, E. Stringer, S. Strong-Sheldrake, N. Stroud, C. Subbe, C.L. Sudlow, Z. Suleiman, C. Summers, C. Summersgill, D. Sutherland, D.L. Sykes, R. Sykes, N. Talbot, A.L. Tan, L. Tarusan, V. Tavoukjian, A. Taylor, C. Taylor, J. Taylor, A. Te, H. Tedd, C.J. Tee, J. Teixeira, H. Tench, S. Terry, S. Thackray-Nocera, F. Thaivalappil, B. Thamu, D. Thickett, C. Thomas, D.C. Thomas, S. Thomas, A.K. Thomas, T. Thomas-Woods, T. Thompson, A.A.R. Thompson, T. Thornton, M. Thorpe, R.S. Thwaites, J. Tilley, N. Tinker, G.F. Tiongson, M. Tobin, J. Tomlinson, C. Tong, M. Toshner, R. Touyz, K.A. Tripp, E. Tunnicliffe, A. Turnbull, E. Turner, S. Turner, V. Turner, K. Turner, S. Turney, L. Turtle, H. Turton, J. Ugoji, R. Ugwuoke, R. Upthegrove, J. Valabhji, M. Ventura, J. Vere, C. Vickers, B. Vinson, E. Wade, P. Wade, L.V. Wain, T. Wainwright, L.O. Wajero, S. Walder, S. Walker, E. Wall, T. Wallis, S. Walmsley, J.A. Walsh, S. Walsh, L. Warburton, T.J.C. Ward, K. Warwick, H. Wassall, S. Waterson, E. Watson, L. Watson, J. Watson, J. Weir McCall, C. Welch, H. Welch, B. Welsh, S. Wessely, S. West, H. Weston, H. Wheeler, S. White, V. Whitehead, J. Whitney, S. Whittaker, B. Whittam, V. Whitworth, A. Wight, J. Wild, M. Wilkins, D. Wilkinson, B. Williams, N. Williams, J. Williams, S.A. Williams-Howard, M. Willicombe, G. Willis, J. Willoughby, A. Wilson, D. Wilson, I. Wilson, N. Window, M. Witham, R. Wolf-Roberts, C. Wood, F. Woodhead, J. Woods, D.G. Wootton, J. Wormleighton, J. Worsley, D. Wraith, C. Wrey Brown, C. Wright, L. Wright, S. Wright, J. Wyles, I. Wynter, M. Xu, N. Yasmin, S. Yasmin, T. Yates, K.P. Yip, B. Young, S. Young, A. Young, A.J. Yousuf, A. Zawia, L. Zeidan, B. Zhao, B. Zheng, and O. Zongo
Subjects: COVID-19, Physical frailty, Long-COVID, Fried's frailty phenotype, Hospitalisation, Medicine (General), R5-920
Abstract: Summary: Background: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. Methods: This prospective cohort study recruited adults who had survived hospitalisation with clinically diagnosed COVID-19 across 35 sites in the UK (PHOSP-COVID). The burden of frailty was objectively measured using Fried's Frailty Phenotype (FFP). The primary outcome was the prevalence of each FFP group—robust (no FFP criteria), pre-frail (one or two FFP criteria) and frail (three or more FFP criteria)—at 5 months and 1 year after discharge from hospital. For inclusion in the primary analysis, participants required complete outcome data for three of the five FFP criteria. Longitudinal changes across frailty domains are reported at 5 months and 1 year post-hospitalisation, along with risk factors for frailty status. Patient-perceived recovery and health-related quality of life (HRQoL) were retrospectively rated for pre-COVID-19 and prospectively rated at the 5 month and 1 year visits. This study is registered with ISRCTN, number ISRCTN10980107. Findings: Between March 5, 2020, and March 31, 2021, 2419 participants were enrolled with FFP data. Mean age was 57.9 (SD 12.6) years, 933 (38.6%) were female, and 429 (17.7%) had received invasive mechanical ventilation. 1785 had measures at both timepoints, of which 240 (13.4%), 1138 (63.8%) and 407 (22.8%) were frail, pre-frail and robust, respectively, at 5 months compared with 123 (6.9%), 1046 (58.6%) and 616 (34.5%) at 1 year. Factors associated with pre-frailty or frailty were invasive mechanical ventilation, older age, female sex, and greater social deprivation. Frail participants had a larger reduction in HRQoL compared with before their COVID-19 illness and were less likely to describe themselves as recovered. Interpretation: Physical frailty and pre-frailty are common following hospitalisation with COVID-19. Improvement in frailty was seen between 5 and 12 months although two-thirds of the population remained pre-frail or frail. This suggests comprehensive assessment and interventions targeting pre-frailty and frailty beyond the initial illness are required. Funding: UK Research and Innovation and National Institute for Health Research.
Published: 2023
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24. Effect of snowfall on changes in relative seismic velocity measured by ambient noise correlation

Author: A. Guillemot, A. van Herwijnen, E. Larose, S. Mayer, and L. Baillet
Subjects: Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract: In mountainous, cold temperate and polar sites, the presence of snow cover can affect relative seismic velocity changes (dV/V) derived from ambient noise correlation, but this relation is relatively poorly documented and ambiguous. In this study, we analyzed raw seismic recordings from a snowy flat field site located above Davos (Switzerland), during one entire winter season (from December 2018 to June 2019). We identified three snowfall events with a substantial response of dV/V measurements (drops of several percent between 15 and 25 Hz), suggesting a detectable change in elastic properties of the medium due to the additional fresh snow. To better interpret the measurements, we used a physical model to compute frequency-dependent changes in the Rayleigh wave velocity computed before and after the events. Elastic parameters of the ground subsurface were obtained from a seismic refraction survey, whereas snow cover properties were obtained from the snow cover model SNOWPACK. The decrease in dV/V due to a snowfall was well reproduced, with the same order of magnitude as observed values, confirming the importance of the effect of fresh and dry snow on seismic measurements. We also observed a decrease in dV/V with snowmelt periods, but we were not able to reproduce those changes with our model. Overall, our results highlight the effect of the snow cover on seismic measurements, but more work is needed to accurately model this response, in particular for the presence of liquid water in the snowpack.
Published: 2021
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25. Brain natriuretic peptide (BNP) measurement during the first year after coronary artery bypass grafting

Author: D. H. L. Bail, Gerhard Ziemer, and Tobias Walker
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.anatomical_structure, Bypass grafting, business.industry, Internal medicine, Cardiology, medicine, Surgery, Cardiology and Cardiovascular Medicine, Brain natriuretic peptide, business, Artery
Published: 2012
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26. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author: H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. 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Valalentino, D. Guidetti, B. Buchwald, C. H. Lücking, D. Gauvreau, F. Pfaff, A. Ben Younes-Chennoufi, R. Kiefer, R. Massot, K. A. Hossmann, L. Werdelin, P. J. Baxter, U. Ziflo, S. Allaria, C. D. Marsden, M. Cabaret, S. P. Mueller, E. Calabrese, R. Colao, S. I. Bekkelund, M. Yilmaz, O. Oktem-Tanor, R. Gine, M. E. Scheulen, J. Beuuer, A. Melo, Z. Gulay, M. D. Have, C. Frith, D. Liberati, J. Gozlan, P. Rondot, Ch. Brunholzl, M. Pocchiari, J. Pena, L. Moiola, C. Salvadori, A. Cabello, T. Catarci, S. Webb, C. Dettmers, N. A. Gregson, Alexandra Durr, F. Iglesias, U. Knorr, L. Ferrini-Strambi, F. Kruggel, P. Allard, A. Coquerel, P. Genet, F. Vinuels, C. Oberwittler, A. Torbicki, P. Leffers, B. Renault, B. Fauser, C. Ciano, G. Uziel, J. M. Gibson, F. Anaya, C. Derouesné, C. N. Anagnostou, M. Kaido, W. Eickhoff, G. Talerico, M. L. Berthier, A. Capdevila, M. Alons, D. Rezek, E. Wondrusch, U. Kauerz, D. Mateo, M. A. Chornet, Holon, N. Pinsard, I. Doganer, E. Paoino, H. Strenge, C. Diaz, J. R. Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg
Subjects: Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published: 1994
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27. Transparent large-strain thermoplastic polyurethane magnetoactive nanocomposites

Author: Mitra Yoonessi, John A. Peck, Justin L. Bail, Richard B. Rogers, Bradley A. Lerch, and Michael A. Meador
Subjects: General Materials Science
Abstract: Organically modified superparamagnetic MnFe(2)O(4)/thermoplastic polyurethane elastomer (TPU) nanocomposites (0.1-8 wt %) were prepared by solvent mixing followed by solution casting. Linear aliphatic alkyl chain modification of spherical MnFe(2)O(4) provided compatibility with the TPU containing a butanediol extended polyester polyol-MDI. All MnFe(2)O(4)/TPU nanocomposite films were superparamagnetic and their saturation magnetization, σ(s), increased with increasing MnFe(2)O(4) content. All nanocomposite films exhibited large deformations (10 mm) under a magneto-static field. This is the first report of large actuation of magnetic nanoparticle nanocomposites at low-loading levels of 0.1 wt % (0.025 vol %). The maximum actuation deformation of the MnFe(2)O(4)/TPU nanocomposite films increased exponentially with increasing nanoparticle concentration. An empirical correlation between the maximum displacement, saturation magnetization, and magnetic nanoparticle loading is proposed. The cyclic deformation actuation of a 6 wt % surface modified MnFe(2)O(4)/TPU, in a low magnetic field 151B(y)303 Oe, exhibited excellent reproducibility and controllability. MnFe(2)O(4)/TPU nanocomposite films (0.1-2 wt %) were transparent and semitransparent over the wavelengths from 350 to 700 nm.
Published: 2011

28. Antimicrobial use prior as a risk factor for developing extended-spectrum beta-lactamse-producing Klebsiella spp. in South Brazil

Author: V Bian, C Busato, L Bail, Carmen Antonia Sanches Ito, da Rocha, C da Silva, and T Ostroski
Subjects: Veterinary medicine, business.industry, medicine.drug_class, lcsh:R, Antibiotics, lcsh:Medicine, General Medicine, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, General Biochemistry, Genetics and Molecular Biology, Klebsiella spp, Antimicrobial use, Poster Presentation, polycyclic compounds, bacteria, Medicine, lcsh:Q, Risk factor, lcsh:Science, business, Pathogen
Abstract: Extended-spectrum beta-lactamase-producing (ESBL) Klebsiella spp. is a problematic nosocomical pathogen around the world. In the present study, we aimed to evaluate the previous use of antibiotics as a risk factor for isolation of ESBL Klebsiella spp.
Published: 2011
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29. Deployment of national criteria for prevention of infection in surgical site in Ponta Grossa, Parana, Brazil

Author: Wddo Collares, Maria Dagmar da Rocha Gaspar, Cld Silva, Cas Ito, L Bail, Crb Grden, and AM Pipino
Subjects: medicine.medical_specialty, Pathology, business.industry, Hospitalized patients, lcsh:R, lcsh:Medicine, General Medicine, General Biochemistry, Genetics and Molecular Biology, Family medicine, Poster Presentation, Health care, Public hospital, Surgical site, medicine, lcsh:Q, lcsh:Science, business, Surgical site infection
Abstract: The Surgical Site Infection (SSI) is one of the chief aggravation related to health care in Brazil, occupying the third position among all infections with a prevalence of 14% to 16% of those found in hospitalized patients. This is a prospective, qualitative and descriptive study whose aim was to implement preventive measures to control SSI at a Public Hospital, Ponta Grossa-PR, 2010.
Published: 2011
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30. PP 7.4 – 00016 Acquisition of SARS-CoV-2 infection during an HIV cure study with an ATI period

Author: I. Mcgowan, L. Bailon, S. Devi, C. Brander, and J.R. Arribas
Subjects: Microbiology, QR1-502, Public aspects of medicine, RA1-1270
Published: 2022
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31. OP 8.3 – 00028 HIV-vaccine induced, broad and polyfunctional CD4 and CD8 T cell responses are associated with prolonged time off ART and lower pVL at the end of ATI in the AELIX-002 therapeutic vaccine trial

Author: B. Mothe, L. Bailon, A. Llano, Y. Alarcon-Soto, and C. Brander
Subjects: Microbiology, QR1-502, Public aspects of medicine, RA1-1270
Published: 2022
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32. PP 1.19 – 00109 Differential decay dynamics of the inducible pool of HIV-1 infected CD4+ T cells and proviral DNA upon ART initiation revealed by the novel VIP-SPOT assay

Author: M.C. Puertas, M.C. Garcia-Guerrero, L. Bailón, B. Mothe, P. Coll, J. Moltó, and J. Martinez-Picado
Subjects: Microbiology, QR1-502, Public aspects of medicine, RA1-1270
Published: 2022
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33. Bridging anticoagulation after prosthetic heart valve replacement – can it be that simple?

Author: Tobias Walker, Thorsten Walles, D. H. L. Bail, Godehard Friedel, D. Graf, Gerhard Ziemer, and Volker Steger
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Bridging (networking), Valve replacement, business.industry, medicine.medical_treatment, medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Prosthetic heart, Simple (philosophy)
Published: 2009
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34. Non-Destructive Investigation & FEA Correlation on an Aircraft Sandwich Composite Structure

Author: Justin L. Bail
Subjects: Engineering, business.industry, Internal pressure, Structural engineering, Aerodynamics, Radome, Fixture, Finite element method, law.invention, Stress (mechanics), Vibration, Shearography, law, business
Abstract: As a result of the increase in use of composites in the Aircraft Industry, use a better knowledge and behavioral prediction is desired. This can be done through computational models and/or physical testing. Numerous FEA programs are used to aid in the design process and to predict the performance and behavior of composite structures. There are also many non destructive methods of investigation (NDI) which are used in both quality control and behavioral observations. A composite flight structure common to many airplanes is a radome, which can be defined as a structural enclosure used to protect an antenna from the environment which includes the aerodynamic loading and weather. FEA model validation is performed by comparison to vibration testing as well as internal pressure testing. Shearography allows us to measure the surface deformation of an object when under a stress. Shearography was completed to determine any possible defects caused in manufacturing (or transporting) the radome. De -lami nation will possibly cause unpredicted response in the vibration or pressure tests. Areas of different construction as well as defects will deflect non -uniformly. There were no flaws detected in the composite radome tested. Laser Doppler Vibrometry (LDV) is a non -contact vibration measurement that is used to determine the natural frequencies and mode shapes of the Composite Radome Structure. The vibration testing was completed using a few different boundary conditions which include approximately free -fre e BC’s and fixed BC’s. The testing has corresponded accurately in comparison to the FEA model however; it is suspected that there is some slight error caused by the fixed fixture for vibration testing.
Published: 2008
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35. Challenging the advanced: cardiac surgery without awareness of a pheochromocytoma

Author: Tobias Walker, D. H. L. Bail, Gerhard Ziemer, E. Schmid, L. Haeberle, and H. Kuehne
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Hemodynamics, Pheochromocytoma, Anastomosis, law.invention, law, medicine, Cardiopulmonary bypass, Humans, Coronary Artery Bypass, Intraoperative Complications, Aged, Cardiopulmonary Bypass, business.industry, Coronary Stenosis, medicine.disease, Surgery, Cardiac surgery, Blood pressure, Bypass surgery, Hemostasis, Anesthesia, Hypertension, Cardiology and Cardiovascular Medicine, business
Abstract: We report the case of a 75-year-old male patient who underwent bypass surgery. Intraoperatively unstable hemodynamics with excessive arterial blood pressure was observed. This resulted in the tearing of an anastomosis, which subsequently required hemostasis for repeated bleeding. Postoperatively, laboratory findings and diagnostic imaging confirmed the diagnosis made intraoperatively of a pheochromocytoma. Any surgery without awareness of the possibility of a pheochromocytoma will dramatically increase intraoperative and postoperative morbidity and mortality, especially in cardiac surgery. The uncontrolled release of catecholamines raises arterial blood pressure which can become life-threatening and lead to serious intraoperative complications, as well as cerebrovascular and cardiac comorbidity.
Published: 2006

36. Successfull reduction ascending aortoplasty – a question of right indication or right technique?

Author: Tobias Walker, M. Gruler, D. H. L. Bail, and Gerhard Ziemer
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, medicine.medical_treatment, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Reduction (orthopedic surgery)
Published: 2006
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37. Modal sensitivity of rock glaciers to elastic changes from spectral seismic noise monitoring and modeling

Author: A. Guillemot, L. Baillet, S. Garambois, X. Bodin, A. Helmstetter, R. Mayoraz, and E. Larose
Subjects: Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract: Among mountainous permafrost landforms, rock glaciers are mostly abundant in periglacial areas, as tongue-shaped heterogeneous bodies. Passive seismic monitoring systems have the potential to provide continuous recordings sensitive to hydro-mechanical parameters of the subsurface. Two active rock glaciers located in the Alps (Gugla, Switzerland, and Laurichard, France) have been instrumented with seismic networks. Here, we analyze the spectral content of ambient noise to study the modal sensitivity of rock glaciers, which is directly linked to the system's elastic properties. For both sites, we succeed in tracking and monitoring resonance frequencies of specific vibrating modes of the rock glaciers over several years. These frequencies show a seasonal pattern characterized by higher frequencies at the end of winters and lower frequencies in warm periods. We interpret these variations as the effect of the seasonal freeze–thawing cycle on elastic properties of the medium. To assess this assumption, we model both rock glaciers in summer, using seismic velocities constrained by active seismic acquisitions, while bedrock depth is constrained by ground-penetrating radar surveys. The variations in elastic properties occurring in winter due to freezing were taken into account thanks to a three-phase Biot–Gassmann poroelastic model, where the rock glacier is considered a mixture of a solid porous matrix and pores filled by water or ice. Assuming rock glaciers to be vibrating structures, we numerically compute the modal response of such mechanical models by a finite-element method. The resulting modeled resonance frequencies fit well the measured ones over seasons, reinforcing the validity of our poroelastic approach. This seismic monitoring allows then a better understanding of the location, intensity and timing of freeze–thawing cycles affecting rock glaciers.
Published: 2021
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38. Book Review

Author: Paul L. Bail
Subjects: Law, General Psychology, Pathology and Forensic Medicine
Published: 1993
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39. Feasibility of enhancing well‐child visits with family nutrition and physical activity risk assessment on body mass index

Author: L. Bailey‐Davis, S. M. R. Kling, G. C. Wood, W. J. Cochran, J. W. Mowery, J. S. Savage, R. A. Stametz, and G. J. Welk
Subjects: BMI, paediatrics, prevention, primary care, Internal medicine, RC31-1245
Abstract: Summary Objective Integration of behavioural risk assessment into well‐child visits is recommended by clinical guidelines, but its feasibility and impact is unknown. Methods A quasi‐experimental study evaluated the feasibility and effectiveness of risk assessment on body mass index (BMI) at 1‐year follow‐up. Children with assessments (intervention) were compared with those who did not complete assessments (non‐respondent) and those who received standard care (non‐exposed). Results Analyses included 10,647 children aged 2–9 years (2,724 intervention, 3,324 non‐respondent and 4,599 non‐exposed). Forty‐five per cent of parents completed the assessments. Intervention and non‐respondent groups differed in change in BMI z‐score at 1 year by −0.05 (confidence interval [CI]: −0.08, −0.02; P = 0.0013); no difference was observed with non‐exposed children. The intervention group had a smaller increase in BMI z‐score (0.07 ± 0.63) than non‐respondent group (0.13 ± 0.63). For children with normal weight at baseline, intervention versus non‐respondent groups differed in BMI z‐score change by −0.06 (CI: −0.10, −0.02; P = 0.0025). However, children with overweight at baseline in the intervention versus the non‐exposed group differed in BMI z‐score change (0.07 [CI: 0.02, 0.14]; P = 0.016). When analysed by age, results were similar for 2‐ to 5‐year‐olds, but no differences were found for 6‐ to 9‐year‐olds. Conclusion Automating risk assessment in paediatric care is feasible and effective in promoting healthy weight among preschool but not older children.
Published: 2019
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40. Personality disorder not otherwise specified heterogeneity and its implication in psychiatric residential treatment

Author: L. Bailo, P. Vimercati, M. Caslini, S. Damiano, and E. Pellegrini
Subjects: PDNOS, Therapeutic Community, Diagnostic agreement, Psychiatry, RC435-571
Abstract: Introduction Villa Ratti is a therapeutic community dedicated to the treatment of Personality Disorder with a particular focus on Borderline Personality Disorder (BPD), but this diagnosis may manifest in very different clinical conditions (Bayer & Parker, 2017; Scott, 2017). Objectives Since the second most common diagnosis we encounter from referring psychiatrists is Personality Disorder Not Otherwise Specified (PDNOS) (26,4%) and this diagnosis serves sometimes as a skeleton key for complex or unclear diagnostic scenarios (Verheul & Widiger, 2004), our main goal is to investigate how the variability within this category is reflected in terms of diagnostic accuracy, different development of the therapeutic and rehabilitative course, and of different outcomes at the end of the treatment. Methods To reach this goal, we collected data on all patients referred with a PDNOS diagnosis and compared their treatment program. scenarios. Results Our data showed how a PDNOS diagnosis hid in most cases complex personality disorders and comorbidities that reflected different specific difficulties and interventions during their treatment and, consequently, resulted in different outcomes. Conclusions Our experience led us to give additional attention to referred PDNOS diagnosis and to observe how much a clear diagnostic picture of a patient is crucial to correctly plan a treatment program and adapt local service interventions both for personality disorder and comorbidity
Published: 2021
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41. Determination of medial temporal lobe atrophy In early Alzheimer's disease with computed tomography

Author: J.P. Pruvo, Florence Lebert, Florence Pasquier, Henri Petit, and L. Bail
Subjects: Text mining, medicine.diagnostic_test, business.industry, Medial temporal atrophy, medicine, Computed tomography, General Medicine, Disease, Anatomy, business
Published: 1994
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42. Administration of brain natriuretic peptide improves cardiac function following operations using extracorporeal circulation in an animal model.

Author: Dorothee H. L. Bail, Volker Steger, Uli Heinzelmann, Sandra Schiller, Anita I. Geim, Benjamin Brüllmann, and Gerhard Ziemer
Subjects: *ATRIAL natriuretic peptides, *PEPTIDE hormones, *ARTIFICIAL blood circulation, *HEART function tests
Abstract: The critical phase during cardiosurgical procedures is weaning the diseased heart from the ECC (extracorporeal circulation). Post-ischaemic heart failure sometimes requires the administration of inotropic and/or vasconstrictive agents. The natriuretic peptides influence pre- and after-load through their natriuretic, diuretic and vasodilating actions. To date, there are only a few reports describing the therapeutic effect of BNP (brain natriuretic peptide) administration during cardiosurgical procedures. The aim of the present study was to evaluate the effect of BNP administration following ECC in an animal model. Surgery was performed on 20 pigs using ECC. A 30-min ischaemic episode was simulated. Following de-clamping, BNP was administered to the BNP group (n=10) by an i.v. (intravenous) bolus at 0.3 μg·kg−1 of body weight·min−1, followed by an infusion at a rate of 0.015 μg·kg−1 of body weight·min−1 for 60 min. The animals in the control group (n=10) received a saline solution instead of BNP. Haemodynamic and clinical chemistry parameters as well as the amount of catecholamines that were required were measured. All of the animals in the BNP group had a significantly better cardiac output and cardiac index at the end of the experiment. Seven out of 10 animals from the control group required catecholamines, whereas only one animal from the BNP group did. Creatine kinase levels were significantly lower in the BNP group. Systemic vascular resistance was markedly lower in the BNP group. In conclusion, administration of BNP is highly effective in treating post-ischaemic heart failure following ECC. Haemodynamics are greatly improved, and there is almost no need for pharmacological support. [ABSTRACT FROM AUTHOR]
Published: 2007
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43. Brain Natriuretic Peptide (BNP) in Patients Undergoing Coronary Artery Bypass Grafting.

Author: D. H. L. Bail
Published: 2004

44. Low viral reservoir treated individuals show unusual HIV latency distribution

Author: C. Gálvez, V. Urrea, S. Benet, B. Mothe, L. Bailón, J. Dalmau, L. Leal, F. García, J. Martinez-Picado, and M. Salgado
Subjects: Microbiology, QR1-502, Public aspects of medicine, RA1-1270
Published: 2019
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45. Evaluation of behaviour in stabled draught horse foals fed diets with two protein levels

Author: C. Sartori, N. Guzzo, S. Normando, L. Bailoni, and R. Mantovani
Subjects: behaviour, dietary protein, draught horse, foals, video recording, Animal culture, SF1-1100
Abstract: The present work is aimed at evaluating the behaviour of Italian Heavy Draught Horse (IHDH) foals reared in semi-covered stables and fed two isoenergetic total mixed rations with different dietary protein levels (13.2% and 10.6% of CP on dry matter). The study was prompted by the restrictions for nitrate emissions in farms of the European Nitrate Directive. One suggested solution is to reduce dietary protein while maintaining normal performance and welfare, but there is a lack of literature in studies of horses. The behaviours of 20 foals of 437±60 kg of BW, aged 379±37 days and stabled in four pens by sex (S) and diet (D) were video recorded and analysed to build a suitable ethogram including 18 behaviours in six categories: ingestion, resting, maintenance, movement, social activities, other. The percentage of the daily time spent in each behavioural category and single behaviours was analysed via a single traits GLM including S, D and their interaction. Daily activity was consistent with existing literature: foals spent about 33% of the day in ingestion activities and 41% in resting, whereas social interactions constituted 8% of the time and individual maintenance
Published: 2017
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46. Influence of meteorological factors on rockfall occurrence in a middle mountain limestone cliff

Author: J. D'Amato, D. Hantz, A. Guerin, M. Jaboyedoff, L. Baillet, and A. Mariscal
Subjects: Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract: The influence of meteorological conditions on rockfall occurrence has been often highlighted, but knowledge of it is still not sufficient due to the lack of exhaustive and precise rockfall databases. In this study, rockfalls have been detected in a limestone cliff by annual terrestrial laser scanning, and dated by photographic survey over a period of 2.5 years. A near-continuous survey (one photo every 10 min) with a wide-angle lens has made it possible to date 214 rockfalls larger than 0.1 m3, and a monthly survey with a telephoto lens has dated 854 rockfalls larger than 0.01 m3. Analysis of the two databases shows that the rockfall frequency can be multiplied by a factor as high as 7 during freeze–thaw episodes and 26 when the mean rainfall intensity (since the beginning of the rainfall episode) is higher than 5 mmh−1. Based on these results, a three-level scale has been proposed for predicting the temporal variations of rockfall frequency. The more precise database and freeze–thaw episode definition make it possible to distinguish different phases in freeze–thaw episodes: negative temperature cooling periods, negative temperature warming periods and thawing periods. It appears that rockfalls occur more frequently during warming and thawing periods than during cooling periods. It can be inferred that rockfalls are caused by thermal ice dilatation rather than by dilatation due to the phase transition. But they may occur only when the ice melts, because the cohesion of the ice–rock interface can be sufficient to hold the rock compartment which has been cut.
Published: 2016
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47. Seismic and mechanical studies of the artificially triggered rockfall at Mount Néron (French Alps, December 2011)

Author: P. Bottelin, D. Jongmans, D. Daudon, A. Mathy, A. Helmstetter, V. Bonilla-Sierra, H. Cadet, D. Amitrano, V. Richefeu, L. Lorier, L. Baillet, P. Villard, and F. Donzé
Subjects: Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract: The eastern limestone cliff of Mount Néron (French Alps) was the theater for two medium-size rockfalls between summer and winter 2011. On 14 August 2011, a ~2000 m3 rock compartment detached from the cliff, fell 100 m below and propagated down the slope. Although most of the fallen rocks deposited on the upper part of the slope, some blocks of about 15 m in size were stopped by a ditch and an earthen barrier after a run-out of 800 m. An unstable overhanging ~2600 m3 compartment remained attached to the cliff and was blasted on 13 December 2011. During this artificially triggered event, 7 blocks reached the same ditch, with volumes ranging from 0.8 to 12 m3. A semi-permanent seismic array located about 2.5 km from the site recorded the two events, providing a unique opportunity to understand and to compare the seismic phases generated during natural and artificially triggered rockfalls. Both events have signal duration of ~100 s with comparable maximum amplitudes recorded at large distances (computed local magnitude of 1.14 and 1.05, respectively), most of the energy lying below 20 Hz. Remote sensing techniques (photogrammetry and lidar) were employed before and after the provoked rockfall, allowing the volume and fracturing to be characterized. This event was filmed by two video cameras, and the generated ground motions were recorded using two temporary 3C seismic sensors and three seismic arrays deployed at the slope toe. Videos and seismogram processing provided estimates of the propagation velocity during the successive rockfall phases, which ranges from 12 to 30 m s−1. The main seismic phases were obtained from combined video and seismic signal analyses. The two most energetic phases are related to the ground impact of fallen material after free fall, and to individual rock block impacts into the ditch and the earthen barrier. These two phases are characterized by similar low-frequency content but show very different particle motions. The discrete element technique allowed reproducing the key features of the rockfall dynamics, yielding propagation velocities compatible with experimental observations.
Published: 2014
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48. Proceedings: Searching for human tumor antigens

Author: N G, Anderson, D W, Holladay, J E, Caton, E L, Candler, P J, Dierlam, J W, Eveleigh, F L, Bail, J W, Holleman, J P, Breillatt, and J H, Coggin
Subjects: Antigens, Neoplasm, Immune Sera, Neoplasms, Protein Biosynthesis, Cell Membrane, Immunologic Techniques, Humans, Antigen-Antibody Complex, Cell Fractionation, Kidney, Autoantigens, Chromatography, Affinity, Culture Media
Published: 1974

49. [Blood relapses and modifications of the pre-erythrocytic shizonts of Plasmodium yoelii using ethionine]

Author: I, Landau, Y, Boulard, F, Miltgen, and O L, Bail
Subjects: Cell Nucleus, Central African Republic, Cytoplasm, Plasmodium, Blood, Time Factors, Liver, Animals, Rodentia, Ethionine
Abstract: Injections of DL-ethionine during the preerythrocytic period of Plasmodium yoeli in Thammomys were followed by: 1. A delayed prepatent period; 2. A relapsing parasitaemia with alternatively positive and negative blood at subinoculation of clean mice; 3. A peculiar morphology of the exoerythrocytic schizonts which remain small with a scanty cytoplasm and very few large nuclei. Although the authors consider the origin of the relapses to be the rupture of delayed hepatic schizonts under the influence of ethionine, none were found after the 5th day.
Published: 1975

50. Relationship between pasture and nutritional aspects of Fontina cheese manufactured in alpine farms

Author: A. Chatel, M. Bassignana, R. Mantovani, and L. Bailoni
Subjects: Fontina cheese, alpine pasture, CLA, heavy metals, Animal culture, SF1-1100
Abstract: In recent years consumers have markedly increased their attention to the quality of foods, as a results of an amplified requirement of safety in all agricultural products, including those of animal origin. As a consequence, there has been a growing interest for the so called functional foods, for foods from the organic agriculture and for the DOP (Protected Origin Denomination) brand products. Fontina cheese is one of the Italian cheeses qualified as DOP, and it is produced exclusively in Valle d’Aosta with raw and whole milk from Valdostana cows. During the summer the cheese is directly manufactured in Alpine farms located in different valleys, and where cows are grazed and moved progressively to higher altitudes.....
Published: 2011
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