Search

Thiosemicarbazones are biological active compounds. In this work, five new thiosemicarbazones were prepared and structurally characterized by elemental analysis, 1H NMR and IR spectra, as well as single crystal X-ray diffraction. The compounds were evaluated for their urease inhibitory activities. Among the compounds, those with hydroxyl substituent groups have effective activity with IC50 values of 1.5-2.3 μmol∙L–1. Docking simulation was performed to insert the molecules of the compounds into the crystal structure of Jack bean urease at the active site to determine their probable binding modes.

Three new mononuclear cobalt(III) complexes, [CoL1(4-Brsal)] (1), [CoL3(4-Brsal)] (2), and [Co(L2)2]NO3 (3), where L1, L2, L3 and 4-Brsal are the deprotonated form of N,N'-bis(4-bromosalicylidene)-1,3-propanediamine, N,N'-bis(4-bromosalicylidene)-1,3-pentanediamine, 5-bromo-2-(((3-(methylamino)propyl)imino)methyl)phenol and 4-bromosalicylaldehyde, respectively, were synthesized and characterized by infrared and electronic spectroscopy, as well as single crystal X-ray diffraction. The Schiff base ligands coordinate to the Co atoms through all the O and N atoms. The Co atoms in the complexes are in octahedral coordination. The complexes show effective antimicrobial activity.