98 results on '"L Lahlou"'
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2. Clinical predictive factors of histological chorioamnionitis: case-control study
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H. Zaidi, N. Lamalmi, L. Lahlou, M. Slaoui, A. Barkat, S. Alamrani, and Z. Alhamany
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Pathology ,Women's health ,Obstetrics & gynecology ,Pregnancy ,Placenta ,Anatomical examination ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Introduction: Histological chorioamnionitis or ''intrauterine inflammation or infection'' (Triple I) it is an acute inflammation of amniotic membrane, chorionic plate and umbilical cord. Subject: To assess in the event of the clinical predictive factors associated to histological chorioamnionitis. Methods: Prospective examination of 50 placentas from aberrant pregnancies, and 50 placentas from 'normal' deliveries. The Placentas analyzed by the conventional histopathology method, and the severity of chorioamnionitis was classified histologically according to the intensity and the topography of placental inflammation.The clinical and histopathological features of the study groups were introduced into the SPSS 13 database (License University Mohammed V-Rabat). Results: 36/50 placentas of aberrant pregnancies showed a histological chorioamnionitis often associated to a funisitis, and 11/50 normal placentas have shown some lesions of histological chorioamnionitis mainly grade one without funisitis.On the other hand we noted a statistically significant association between histological chorioamnionitis and premature rupture of the membranes (PROM) over than 12h (p < 0.001). Conclusions: Our study confirmed the predominance of histological chorioamnionitis lesions in clinically suspected cases of chorioamnionitis with 72% versus 22% in the controls group.Among the clinical parameters studied, only the premature rupture of the Membranes was shown a statistically significant association with the appearance of histological signs of chorioamnionitis.In conclusion, chorioamnionitis is sometimes clinically silent. Morphological placental study could be a confirmation of this pathology, which is predominantly associated to PROM over than 12 h.
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- 2020
- Full Text
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3. Ischemic stroke in Morocco: Prehospital delay and associated factors
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Ahmed Kharbach, J. Aasfara, Abderrahmane Achbani, Kenza Hassouni, Rachid Razine, L. Lahlou, and Majdouline Obtel
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Emergency Medical Services ,medicine.medical_specialty ,Time Factors ,Epidemiology ,Cross-sectional study ,Disease ,030501 epidemiology ,Logistic regression ,Brain Ischemia ,03 medical and health sciences ,medicine ,Humans ,Prospective Studies ,Stroke ,Ischemic Stroke ,business.industry ,Medical record ,Public Health, Environmental and Occupational Health ,Emergency department ,medicine.disease ,Morocco ,Cross-Sectional Studies ,Public hospital ,Emergency medicine ,Observational study ,Emergency Service, Hospital ,0305 other medical science ,business - Abstract
Objectives This study aimed to estimate prehospital delay and to identify the factors associated with the late arrival of patients with ischemic stroke at the Souss Massa Regional Hospital Center in Morocco. Patients and methods An observational, prospective, cross-sectional study was conducted from March 2019 to September 2019 in the Souss Massa regional hospital center, which is a public hospital structure. A questionnaire was administered to patients with ischemic stroke and to bystanders (family or others), while clinical and paraclinical data were collected from medical records. Univariate and multivariate logistic regression analyses were used to identify the factors associated with delayed arrival at emergency department. Results A total of 197 patients and 197 bystanders who fulfilled the criteria for the study were included. The median time from symptom onset to hospital arrival was 6 hours (IQR, 4–16). Multiple regression analysis showed that illiteracy (OR 38.58; CI95%: 3.40–437.27), waiting for symptoms to disappear (patient behavior) (OR 11.24; CI95%: 1.57–80.45), deciding to go directly to the hospital (patient behavior) (OR 0.07; CI95%: 0.01–0.57), bystander's knowledge that stroke is a disease requiring urgent care within a limited therapeutic window (OR 0.005; CI95%: 0.00–0.36), and direct admission without reference (OR 0.005; CI95%: 0.00–0.07), were independently associated with late arrival (> 4.5 hours) of patients with acute ischemic stroke. In addition, illiteracy (OR 24.62; CI95%: 4.37–138.69), vertigo and disturbance of balance or coordination (OR 0.14; CI95%: 0.03–0.73), the relative's knowledge that stroke is a disease requiring urgent care and within a limited therapeutic window (OR 0.03; CI95%: 0.00–0.22), calling for an ambulance (relative's behavior) (OR 0.16; CI95%: 0.03–0.80), distance between 50 and 100 km (OR 10.16; CI95%: 1.16–89.33), and direct admission without reference (OR 0.03; CI95%: 0.00–0.14), were independently associated with late arrival (> 6 hours) of patients with acute ischemic stroke. Conclusion Patient behavior, bystander knowledge and direct admission to the competent hospital for stroke care are modifiable factors potentially useful for reducing onset-to-door time, and thereby increasing the implementation rates of acute stroke therapies.
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- 2021
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4. University students' perceptions and factors contributing to obesity and overweigh in Southern of Morocco
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Mohamed Boukrim, Rachid Razine, Majdouline Obtel, and L. Lahlou
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Male ,obesity ,Health Knowledge, Attitudes, Practice ,Adolescent ,Universities ,media_common.quotation_subject ,Weight load ,education ,Primary education ,female students ,perception ,Overweight ,Logistic regression ,Young Adult ,Promotion (rank) ,Surveys and Questionnaires ,Perception ,Body Image ,medicine ,overweight ,Humans ,Students ,Female students ,media_common ,business.industry ,Articles ,General Medicine ,Anthropometry ,medicine.disease ,Obesity ,Morocco ,Cross-Sectional Studies ,Logistic Models ,higher education ,Female ,medicine.symptom ,business ,Demography - Abstract
Background: Weight load is a cosmopolitan health problem. In Morocco, women are the most affected by the phenomenon since obesity has risen from 26.8% to 29.0%. Objective: To determine the prevalence of weight load and associated factors among female students in higher education. Methods: Data were collected by a questionnaire. Anthropometric measurements were made using a scale and a wall-mount- ed scale. Data were analysed by the statistical software SPSS version 13.0. Quantitative variables were described in mean ± standard deviation. Factors associated with obesity were determined by binary logistic regression. Results: About two-thirds of the students had a normal weight, 21% were overweight and 3% were obese. In addition, 58% of students were physically inactive and 77% ate cake and fast food. In addition, 63% of students were dissatisfied with their weight. A significant relationship is found between level of primary education, type of establishment, cake and fast food consumption and weight load. Conclusion: The results revealed that 24% of participants were weight load and had behavioral risk factors such as a sed- entary lifestyle and an unbalanced diet, which requires the promotion of a healthy lifestyle among these students as well as psychological support for those dissatisfied with their body image. Keywords: Weight load; obesity; overweight; perception; female students; higher education; Morocco.
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- 2021
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5. P020 - Anxiété et dépression chez les femmes atteintes du cancer du sein et sous traitement au sud du Maroc - Etude transversale
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S. Mahlaq, L. Lahlou, R. Abouqal, and J. Belayachi
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Epidemiology ,Public Health, Environmental and Occupational Health - Published
- 2023
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6. Association of Prostate Cancer with Nuts, Seeds, Alcohol and Processed Meats: A Worldwide Population-Based Study
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Yann Neuzillet, Farida Ajdi, Francesco Sanguedolce, Alae M Touzani, Shahrokh F. Shariat, Imad Ziouziou, Youssef Khabbal, and L. Lahlou
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0301 basic medicine ,Cancer Research ,Meat ,MEDLINE ,Medicine (miscellaneous) ,Dietary factors ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Risk Factors ,Environmental health ,Humans ,Nuts ,Medicine ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Incidence (epidemiology) ,Prostatic Neoplasms ,medicine.disease ,Diet ,Population based study ,Oncology ,030220 oncology & carcinogenesis ,Seeds ,business - Abstract
There are conflicting data with regards to the link between diet and the prostate cancer. The purpose of this study was to assess the association of dietary factors with incidence, prevalence and mortality rates of prostate cancer worldwide. We conducted an ecological study including 170 countries, whose data on incidence, prevalence and mortality rates of prostate cancer, dietary factors, and potentially confounding factors were available and collected in May 2020. Univariable and multivariable linear regression analyses were used. Consumption of nuts and seeds was inversely associated with incidence, prevalence and mortality rates of prostate cancer (β -0.7
- Published
- 2020
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7. Prevalence of Post Traumatic Stress Disorder among School-age Adolescent
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L. Lahlou, Hassan Aguenaou, Amina Barkat, and Khalid Astitene
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Community and Home Care ,School age child ,business.industry ,education ,Traumatic stress ,Medicine ,business ,Clinical psychology - Abstract
Aim: After a traumatic event, the person can develop post-traumatic stress disorder (PTSD), the purpose of the study is to assess the prevalence of PTSD in adolescents in public middle schools of the prefecture of Salé in Morocco and study anxiety and depression which are the comorbid disorders of the PTSD. The survey was carried out from March to June 2017. Methods: 523 students were selected by the cross-sectional method from fifteen schools that were randomly selected, the age of the students vary between 12 and 17 years. For the survey, standardized questionnaires (the socio-demographic data, the Life Events Checklist, the CPTS-RI (Children's Post Traumatic Stress Reaction Index), the STAIY (State Trait Inventory Anxiety Form Y) and the CDI (Children Depression Inventory) were used which were filled in by the students. Results: The prevalence of PTSD was 70.4% in the students who have PTSD. We found that the prevalence in boys was 46.74%, while in girls it was 53.26%. In addition to that, 81% of students found to be anxious and 51.8% of students have depression. Conclusion: There is a high prevalence of post traumatic stress disorder among adolescents, there are practical implications for the support and care of these adolescents.
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- 2020
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8. Prevalence of Post-Traumatic Stress Disorder among School-Age Adolescent
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Khalid Astitene, Amina Barkat, L. Lahlou, and Hassan Aguenaou
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School age child ,business.industry ,mental disorders ,education ,Traumatic stress ,Medicine ,Building and Construction ,business ,Clinical psychology - Abstract
Aim After a traumatic event, the person can develop post-traumatic stress disorder (PTSD), the purpose of the study is to assess the prevalence of PTSD in adolescents in public middle schools of the prefecture of Salé in Morocco and study anxiety and depression which are the comorbid disorders of the PTSD. Methods 523 students were selected by the cross-sectional method from twenty five schools that were randomly selected, the age of the students vary between 12 and 17 years. For the survey, standardized questionnaires (the socio-demographic data, the Life Events Checklist, the CPTS-RI, the STAIY and the CDI) were used which were filled in by the students. Results The prevalence of PTSD was 70.4% in the students who have PTSD. We found that the prevalence in boys was 46.74%, while in girls it was 53.26%. In addition to that, 81% of students found to be anxious and 51.8% of students have depression. Conclusion There is a high prevalence of post-traumatic stress disorder among adolescents. There are practical implications for the support and care of these adolescents.
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- 2020
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9. Decline in childhood respiratory-related mortality after the introduction of the pneumococcal conjugate vaccine in Morocco
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Imad Cherkaoui, Majdouline Obtel, Mustapha Mrabet, Abdelilah Elmarnissi, Aziza Lyaghfouri, L. Lahlou, Redouane Abouqal, Nada Bennani Mechita, and Rachid Razine
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0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Respiratory Tract Diseases ,030106 microbiology ,Pneumococcal Infections ,Pneumococcal conjugate vaccine ,lcsh:Infectious and parasitic diseases ,Pneumococcal Vaccines ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,lcsh:RC109-216 ,030212 general & internal medicine ,Respiratory system ,Vaccines, Conjugate ,business.industry ,Mortality rate ,lcsh:Public aspects of medicine ,Vaccination ,Public Health, Environmental and Occupational Health ,Infant ,Interrupted Time Series Analysis ,lcsh:RA1-1270 ,General Medicine ,Pneumonia, Pneumococcal ,Hospitalization ,Child mortality ,Morocco ,Streptococcus pneumoniae ,Infectious Diseases ,Child, Preschool ,Child Mortality ,business ,medicine.drug - Abstract
Aim: The objective of this study was to analyse the effect of the introduction in 2010 of the pneumococcal conjugate vaccine (PCV) on the reduction in mortality from respiratory causes in children under 5 years in Morocco. Methods: Child mortality rates from respiratory cause were analysed using an interrupted time series analysis. Mortality rates from congenital and chromosomal causes were also analysed for comparative purposes. Results: In the post-vaccination period, child mortality rates from respiratory causes decreased by 28% (Mortality rate ratio (MRR) = 0.72, 95% CI: 0.58–0.83) and by 30% in children under 1 year (MRR = 0.70, 95% CI: 0.50–0.98). In children aged between 1 and 5 years, the decrease in the child mortality rate was not statistically significant (MRR = 0.99, 95% CI: 0.91–1.08). Mortality rates from congenital and chromosomal causes in the post-vaccination period were stable in children under 5 years (MRR = 1.19, 95% CI: 0.97–1.48), in children under 1 year (MRR = 1.15, 95% CI: 0.94–1.40) and in children aged between 1 and 5 years (MRR = 1.19, 95% CI: 0.97–1.48). Conclusion: The decrease in child mortality from respiratory causes in the post-vaccination period provides strong evidence of the effectiveness of PCV. Keywords: Child mortality, Pneumococcal conjugate vaccine, Interrupted time series analysis, Morocco
- Published
- 2020
10. PERSISTENCE OF SYMPTOMS AFTER COVID INFECTIONAMONG HEALTHCARE PROFESSIONALS: A CROSS SECTIONAL STUDY
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O. Benlenda , A. Elmekkaoui , Y. Dakhama and L. Lahlou and H. Nassik
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Long COVID Covid Long-Haulers SARS- CoV-2 - Abstract
Introduction:The symptomatology associated with covid-19 infection has been well described throughout the literature, however little data exists on the persistence of symptoms post the initialrecovery. Material and method:This is a descriptive cross-sectional observational study whose objectives were to determine the prevalence of persistent symptoms and to evaluate the quality-of-lifeamong health professionals diagnosedwith covid-19 in the Souss Massa region in September 2021. Results:One hundred and eighty-three healthcare professionals were included in the study, 123 (67%) of whom were women. The mean age was 35 ± 11 years with a range of 22 to 60 years. The main comorbidities were obesity, asthma and dysthyroidism. Participants with covid-19 infection were symptomatic 82% (152 cases) of the time and were evaluated on average 40 days after the onset of the first symptom. At the time of evaluation, 30% (54 cases) were completely cured, however 70% (129 cases) of participants maintained at least one chronic symptom. Of these symptoms, 59% (108 cases) reported fatigue, 28.4% (52 cases) cough, 18.6% (34 cases) headache and 22% (40 cases) anosmia. In addition, a decrease in quality of life was observed among 29% (53 cases) of the participants. Conclusion:Covid-19 can lead to prolonged illness and persistent symptoms, even among young adults and individuals with no or few comorbidities who have not been hospitalized. The persistence of symptoms impacts ones quality of life, both physically and mentally, which supports the need for regular assessment and monitoring of individuals post covid-19 recovery.  
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- 2022
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11. EPIDEMILOGICAL, CLINICAL AND ECHOCARDIOGRAPHIC FEATURES OF HEART FAILURE IN MOROCCO
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A. Maliki Alaoui , Y. Fihri , A. Ben El Mekki , H.Bouzelmat , I. Asfalou , N. Mouine , A. Benyass and L. Lahlou , R. Razine and R. Abouqal
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Heart Failure Epidemiology Ejection Fraction Morocco - Abstract
Heart failure (HF) is a major public issue taking an epidemic dimension globally.Its incidence is continuing to rise because of a growing and aging population. We held across-sectional retrospective studyin the cardiology department of Mohamed V military teaching hospital of Rabat in morocco fromSeptember 2019 toSeptember 2021, including 104 patients admitted with HF. The mean age was 68.5 ±10.3year. Hypertension and diabetes mellitus are the most common risk factors. HF with reduced ejection fraction represents about 49%. Forty-four percent had dilated cardiomyopathy. Ischemic heart disease is the first cause of HF.  
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- 2021
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12. Analyse épidémiologique du burn-out chez les étudiants en médecine : enquête menée chez les étudiants en médecine à la Faculté de médecine et de pharmacie d'Agadir
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L. Lahlou, O. El oumary, M. Ouhamou, Z. Salehddine, K. Mouhadi, and I. Rammouz
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Epidemiology ,Public Health, Environmental and Occupational Health - Published
- 2022
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13. L'impact de la pandémie Covid-19 sur les patients ayant le trouble bipolaire : Spécificité féminine
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M. Ouhamou, L. Lahlou, O. El oumary, H. Laaraj, J. Doufik, K. Mouhadi, and I. Rammouz
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Epidemiology ,Public Health, Environmental and Occupational Health - Published
- 2022
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14. Pre-Hospital Delay and Associated Factors of Ischemic Stroke in Northern Mediterranean Countries: A Literature Review
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Ahmed Kharbach, Majdouline Obtel, Mohamed Amine Baba, L. Lahlou, and Rachid Razin
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Mediterranean climate ,medicine.medical_specialty ,business.industry ,Ischemic stroke ,Emergency medicine ,medicine ,Ocean Engineering ,Safety, Risk, Reliability and Quality ,business - Published
- 2019
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15. Clinical predictive factors of histological chorioamnionitis: case-control study
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Amina Barkat, L. Lahlou, M. Slaoui, H. Zaidi, Z. Alhamany, S. Alamrani, and Najat Lamalmi
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0301 basic medicine ,medicine.medical_specialty ,Pathology ,Women's health ,Placenta ,Anatomical examination ,Clinical chorioamnionitis ,Prom ,Chorioamnionitis ,Umbilical cord ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Funisitis ,medicine ,Obstetrics & gynecology ,Intrauterine infection ,lcsh:Social sciences (General) ,lcsh:Science (General) ,Multidisciplinary ,business.industry ,Case-control study ,medicine.disease ,Histological chorioamnionitis ,030104 developmental biology ,medicine.anatomical_structure ,Histopathology ,lcsh:H1-99 ,business ,030217 neurology & neurosurgery ,Research Article ,lcsh:Q1-390 - Abstract
Introduction Histological chorioamnionitis or "intrauterine inflammation or infection" (Triple I) it is an acute inflammation of amniotic membrane, chorionic plate and umbilical cord. Subject To assess in the event of the clinical predictive factors associated to histological chorioamnionitis. Methods Prospective examination of 50 placentas from aberrant pregnancies, and 50 placentas from 'normal' deliveries. The Placentas analyzed by the conventional histopathology method, and the severity of chorioamnionitis was classified histologically according to the intensity and the topography of placental inflammation. The clinical and histopathological features of the study groups were introduced into the SPSS 13 database (License University Mohammed V-Rabat). Results 36/50 placentas of aberrant pregnancies showed a histological chorioamnionitis often associated to a funisitis, and 11/50 normal placentas have shown some lesions of histological chorioamnionitis mainly grade one without funisitis. On the other hand we noted a statistically significant association between histological chorioamnionitis and premature rupture of the membranes (PROM) over than 12h (p < 0.001). Conclusions Our study confirmed the predominance of histological chorioamnionitis lesions in clinically suspected cases of chorioamnionitis with 72% versus 22% in the controls group. Among the clinical parameters studied, only the premature rupture of the Membranes was shown a statistically significant association with the appearance of histological signs of chorioamnionitis. In conclusion, chorioamnionitis is sometimes clinically silent. Morphological placental study could be a confirmation of this pathology, which is predominantly associated to PROM over than 12 h., Pathology; Women's health; Obstetrics & gynecology; Pregnancy; Placenta, Anatomical examination, Intrauterine infection, Clinical chorioamnionitis, Histological chorioamnionitis.
- Published
- 2020
16. Level of Knowledge on Stroke and Associated Factors: A Cross-Sectional Study at Primary Health Care Centers in Morocco
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Abderrahmane Achbani, Youssef Bouchriti, Ahmed Kharbach, Rachid Razine, Kenza Hassouni, L. Lahlou, and Majdouline Obtel
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Adult ,Male ,Rural Population ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,Cross-sectional study ,Population ,Primary education ,Infectious and parasitic diseases ,RC109-216 ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Literacy ,Residence Characteristics ,Risk Factors ,medicine ,Humans ,030212 general & internal medicine ,education ,Health Education ,Stroke ,Functional illiteracy ,Depression (differential diagnoses) ,Aged ,Original Research ,Aged, 80 and over ,education.field_of_study ,Primary Health Care ,business.industry ,030503 health policy & services ,General Medicine ,Middle Aged ,medicine.disease ,Morocco ,Cross-Sectional Studies ,Family medicine ,Hypertension ,Multivariate Analysis ,Educational Status ,Female ,Health education ,Public aspects of medicine ,RA1-1270 ,0305 other medical science ,business - Abstract
Background: Stroke is increasingly becoming a major cause of disability and mortality. However, it can be prevented by raising awareness about risk factors and early health care management of patients. Objective: The aim of this study is to assess the level of knowledge on stroke, its risk factors, and warning signs in the population attending urban primary health care centers in the city of Agadir, Morocco. Methods: This is a multicentric cross-sectional study with a descriptive and analytical purpose. The study was conducted at five urban primary health care centers in Agadir in centralwest Morocco. All persons over the age of 18 years who consulted the health centers and who agreed to fill in the questionnaire were recruited, except for the foreign population and health workers. An interview questionnaire was used to assess the level of knowledge on stroke. Findings: A total of 469 participants were involved in the study. The median knowledge score was 8 (Interquartile range 4–13). High blood pressure (55.7%), depression and stress (48.8%) were the most well-known risk factors. Sudden weakness of the face, arms or legs (37.3%) was the main warning sign cited by the participants. Multivariate analysis revealed that illiteracy (OR 1.92; CI95%: 1.08–3.44) primary education (OR 3.43; CI95%: 1.63–7.21), rural residential (OR 1.67; CI95%: 1.07–2.59), no history of stroke among respondents (OR 16.41; CI95%: 4.37–61.59) and no history of stroke among relatives, acquaintances, or neighbors (OR 4.42; CI95%: 2.81–6.96), were independently associated with a lower level of knowledge of stroke (Table 4). Conclusions: The low level of knowledge on stroke among this Moroccan population indicates the importance of implementing stroke education initiatives in the community. More specifically, proximity education and awareness programs ought to be considered to anchor lifestyle preventive behaviors along with appropriate and urgent actions regarding the warning signs of stroke.
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- 2020
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17. EVALUATION OF THE KNOWLEDGE AND THE PRACTICES OF HYGIENE OF HANDS AT THE BURNED SERVICE OF THE MOHAMED V MILITARY TRAINING HOSPITAL
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A achbouk, l Lahlou, S. Siah, y Ribag, and mk Elkhatib
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Service (business) ,Nursing ,Hygiene ,media_common.quotation_subject ,Hand hygiene ,Hydro-alcoholic solutions ,Burning ,Psychology ,Training (civil) ,media_common - Abstract
Objectif:L?hygi?ne des mains estun ?l?mentessentiel de la pr?vention des infections nosocomiales et de la qualit? des soins et par cons?quentune diminution de la morbidit? et de la mortalit? des br?l?s. Notre travail avait pour but d??valuer les connaissances et les pratiquessurl?hygi?ne des mains. M?thodes:L??tude a ?t?r?alis?e au niveau du centre de traitement des br?l?s de l?h?pitalmilitaire Mohammed V de Rabat ets?estd?roul?e du 1er au 15 Janvier 2018. R?sultats:Nous avonsinterrog?39 personnes du personnel. 69.2% du personnel soignantignorent le principal mode de transmission crois?e des germes entre les patients dans un ?tablissement de soins, 66.7% du personnel soignant ne savent pas la source microbienne la plus fr?quemmentresponsabled?infectionsassoci?es aux soins;concernant le timing de ces actions d?hygi?ne, 23.1% du personnel interrog?ssaventqu?ilfaut les appliqueravant le contact avec le patient. Seulement 7.7% du personnel de sant? savent ?quel moment les actions de l?hygi?ne des mains permettent de pr?venir la transmission de germes au soignant. La quasi-totalit? du personnel (94.9 %) penseque les solutions hydro-alcooliquessontmoinsefficacesque le lavage simple des mains, plus de la moiti? (59 %) que la friction hydro-alcooliqueest plus rapideque le lavage au savon et ? l?eau. Dans76.9 % des cas, le personnel penseque les solutions hydro-alcooliquesprovoquentune plus grandes?cheressecutan?eque le lavage des mains. La dur?e de la proc?dure de friction hydro-alcoolique des mains estm?connue de 84.6 % du personnel. Enfin, 20.5% du personnel soignantsontconscients des situations qui favoriseraient la colonisationmicrobienne des mains. Conclusion: les r?sultatsmontrentunbesoin imminent de formation et d?information du personnel du centre de traitement des br?l?s, un plan d?actionvisant ? promouvoir les mesuresd?hygi?nes?av?re indispensable.
- Published
- 2018
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18. Post Traumatic Stress Disorder among Adolescents Schooled in Public Schools
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Khalid Astitene, L. Lahlou, and Amina Barkat
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business.industry ,education ,Life events ,Traumatic stress ,behavioral disciplines and activities ,Unexpected death ,mental disorders ,Medicine ,Anxiety ,medicine.symptom ,business ,Practical implications ,Depression (differential diagnoses) ,Clinical psychology - Abstract
Objective: A traumatic event has a negative impact on the psychological well-being of adolescents, the purpose of our study is to assess the post-traumatic stress disorder PTSD in adolescents in public schools of the prefecture of Sale in Morocco, to evaluate comorbid disorders and thus to study the effect of PTSD on their social and academic life. Method and measures: 871 school adolescents who completed the objectives of the study, their age varied between 12 and 17 years and they completed by themselves the questionnaires concerning socio-demographic data, a list of life events, the CPTS-RI (Children’s Post Traumatic Stress Reaction Index) for assessing the symptoms of PTSD, STAIY (State Trait Inventory Anxiety) and CDI (Children Depression Inventory). Results: A large proportion of post-traumatic stress disorder was found in students with 63.9% but with different levels (19.5% PTSD low, 25.1% PTSD moderate, 18.1% PTSD severe and only 1.2% PTSD very severe). 84.4% of students are anxious and 55.2% of students have depression. Adolescents who have been exposed to at least one traumatic event in their lifetime have 88.69%. In the event, the main traumatic condition that caused the post-traumatic stress disorder was the sudden and unexpected death of a loved one with 27.7%. PTSD, anxiety and depression have a negative effect on students’ school life; therefore, 72.5% of students have poor grades. Conclusion: A traumatic event can develop at a PTSD. There is a high rate of post-traumatic stress disorder and students are in school deficit. There are practical implications for the support and care provided to these adolescents.
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- 2018
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19. Les lymphomes au Sud du Maroc : étude descriptive sur les cinq dernières années
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Y. Khabbal, L. Lahlou, A. Kharbach, and S. Fares
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction Les lymphomes representent un groupe heterogene d’hemopathies malignes dues a un dereglement monoclonal qui survient pendant une des etapes de maturation des lymphocytes. La morphologie des cellules lymphomateuses et l’architecture de la proliferation definissent leur type histologique. Les lymphomes sont repartis en deux groupes : les lymphomes de Hodgkin (LH) et les lymphomes non Hodgkinien (LNH). Au Maroc, 1500 nouveaux cas sont diagnostiques chaque annee, avec un nombre total de 7500 patients atteints de lymphomes. Dans 90 % des cas, l’etiologie du lymphome reste inconnue, cependant, certains facteurs de risque ont ete retenus tels que l’immunodepression et les pathologies auto-immunes. D’autres facteurs restent incrimines dans l’augmentation du risque de lymphome tels que l’exposition aux radiations ionisantes, aux dioxines et aux pesticides. La Region de Souss-Massa est une region agricole par excellence situee au Sud du Maroc et draine tous les malades du Sud Marocain. Cette etude avait pour objectif de decrire le profil epidemiologique des lymphomes dans la Region de Souss-Massa. Methodes Une etude transversale, retrospective a visee descriptive portant sur tous les dossiers des malades atteints de lymphome et suivis entre le 1er janvier 2015 et le 31 decembre 2019 au Centre regional d’oncologie d’Agadir (CROA). Les donnees ont ete recueillies en utilisant une fiche d’exploitation et traitees par logiciel SPSS13.0. Les variables quantitatives de distribution gaussiennes ont ete decrites en moyenne et ecart-type puis compares par test T de Student. Les variables quantitatives de distribution non gaussiennes ont ete decrites en mediane et intervalle interquartiles puis compares par test non parametrique de Mann-Whitney. Les variables qualitatives ont ete decrites en effectifs et pourcentage puis compares par test de Chi2 ou Fisher exact selon les conditions d’applications de chacun des tests. Le seuil de significativite fixe a 5 %. L’anonymat et la confidentialite ont ete respectes dans toutes les etapes de traitement des donnees. Resultats Sur cinq ans, 146 patients ont ete colliges, l’âge moyen etait de 50 ans ± 20,47. Le sexe ratio H/F = 1,03. Un tiers des patients provenaient de la province de Taroudant et 93,2 % des patients etaient sous Regime d’Assistance Medicale pour Demunis (RAMED). Tous les patients avaient un etat general conserve a l’admission et ils avaient des adenopathies a l’examen physique. Sur le plan histologique, 29 patients (19,9 %) avaient un LH et 117 patients (80,1 %) avaient un LNH dont 94 patients (64,4 %) etaient de phenotype B et 23 patients (15,8 %) de phenotype T. Les stades avances (III- IV) etaient notes chez 109 patients (74,6 %). La localisation ganglionnaire etait notee chez 103 patients (70,5 %). La chimiotherapie etait le traitement principal chez 142 patients (98,6 %). La remission a ete notee dans 110 cas (75,3 %). L’analyse comparative en fonction du sexe, a montre une predominance masculine dans les LNH a 55,6 % et feminine dans les LH a 69 % (p = 0,022). Les LNH etaient plus frequents chez les sujets âges avec une moyenne d’âge de 53,62 ans ± 19,04 et le LH etait predominant chez les sujets jeunes avec une moyenne d’âge de 36,62 ans ± 20,7 (p Conclusion Ces resultats constituent les premieres donnees epidemiologiques de la Region de Souss-Massa et vont nous permettre d’avoir un etat des lieux sur lequel il faut concevoir d’autres etudes plus exhaustives voire etiologiques afin de determiner les facteurs associes au lymphome dans la region.
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- 2021
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20. Obésité et surpoids : prévalence et facteurs associés chez les étudiantes de l’enseignement supérieur au sud du Maroc
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Majdouline Obtel, L. Lahlou, Rachid Razine, and M. Boukrim
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction La charge ponderale est un phenomene cosmopolite. Au Moyen-Orient, les etudes ont montre que les femmes de Bahrein et d’Egypte etaient en surpoids ou obeses, suivies des femmes en Jordanie, en Syrie et a Oman. Au Maroc, les femmes sont les plus touchees par le phenomene puisque l’obesite est passee de 26,8 % a 29,0 %. L’etude visait l’estimation de la prevalence de la charge ponderale et les facteurs associes chez les jeunes etudiantes de l’enseignement superieur. Materiels et methodes Il s’agit d’une etude transversale sur un echantillon de 200 etudiantes. Les donnees ont ete collectees par questionnaire standardise. Les mesures anthropometriques etaient realisees a l’aide d’une balance et une toise murale de reference. Le traitement des donnees a ete fait par le logiciel de traitement des donnees statistiques SPSS version 13.0 L’etude est menee en respectant l’anonymat, la confidentialite des informations et le consentement libre et eclaire des participantes. Les variables qualitatives etaient decrites en effectif et pourcentage puis comparees par test de Chi2 et de Fisher exact selon les conditions d’application de chacun. Les variables quantitatives etaient decrites en moyenne ± ecart-type. Les facteurs associes a l’obesite ont ete determine par regression logistique binaire. Resultats Au total, 60 % (n = 120) des etudiants avaient une corpulence normale, 21 % (n = 42) etaient en surpoids et 3 % (n = 6) etaient obeses ; 58 % (n = 116) des etudiantes ne pratiquaient pas d’activite physique et 77 % (n = 154) consommaient une alimentation riche en sucre et des fast-foods. De plus, 63 % (n = 126) des etudiantes etaient insatisfaites de leurs poids. Une relation significative est constatee entre la charge ponderale et le niveau d’instruction primaire des parents, l’insatisfaction du poids, le type d’etablissement, la consommation des sucres et des fast-foods et la perception de perte ou du gain du poids. Conclusion Les resultats de l’etude ont revele des facteurs de risque comportementaux pour la sante tels que la sedentarite et une alimentation riche en sucre et acides gras ce qui necessite la mise en place d’un programme d’education en nutrition pour ces jeunes etudiantes.
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- 2020
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21. Évaluation des connaissances du grand public en matière de l’accident vasculaire cérébral – Une étude transversale à Agadir Ida-Outanane, Maroc
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Abderrahmane Achbani, Rachid Razine, L. Lahlou, Ahmed Kharbach, and Majdouline Obtel
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction L’accident vasculaire cerebral est une cause majeure d’invalidite et de mortalite. En revanche, il peut etre prevenu en sensibilisant davantage le public aux facteurs de risque. Methodes Il s’agit d’une etude transversale prospective menee au niveau des centres de sante urbain de premier niveau relevant de la delegation du ministere de la sante d’Agadir Ida-Outanane au Maroc. A l’exception du personnel de sante, toutes les personnes âgees de ≥ 18 ans, qui ont visite les centres pour une raison ou une autre et qui se sont portees volontaires pour repondre au questionnaire par entretien de l’etude, ont ete recrutees. Le niveau de connaissance sur l’accident vasculaire cerebral a ete evalue sur 23 points correspondant a 23 questions portant sur des generalites sur l’accident vasculaire cerebral, les signes d’alerte ou d’alarme, et les facteurs de risque. Des analyses de regression logistique univariee et multivariee ont ete realisees afin d’identifier les facteurs influencant le niveau de connaissance faible de la population etudiee en matiere de l’accident vasculaire cerebral. Resultats Au total, 469 participants (59,5 % de femmes) ont ete colliges. L’âge median etait de 35 ans (intervalle interquartile : 23–51 ans) ; 30,5 % et 26,9 % des participants etaient respectivement des patients hypertendus et diabetiques connus. Le score moyen des connaissances etait de 8,87 ± 5,76. L’hypertension arterielle (55,7 %), la depression et le stress (48,8 %) etaient les facteurs de risque les plus connus. La faiblesse soudaine du visage, des bras ou des jambes (37,3 %) etait le principal signe d’alerte cite. L’analphabetisme et le niveau d’instruction primaire, le milieu de residence rural, un antecedent personnel de l’accident vasculaire cerebral et une connaissance anterieure d’une personne de l’entourage victime d’accident vasculaire cerebral etaient independamment associe a un niveau de connaissances plus faible en matiere de l’accident vasculaire cerebral. Conclusions Le niveau de connaissance du grand public frequentant les etablissements relevant du reseau des soins de sante primaire de la ville d’Agadir sur l’accident vasculaire cerebral reste faible. Des efforts de sensibilisation de masse sont necessaires, en ciblant les personnes les moins instruites et habitant dans les zones periurbaines et rurales, dans la perspective d’ancrer des comportements preventifs vis-a-vis de cette maladie invalidante.
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- 2020
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22. Ischemic stroke in Morocco: a systematic review
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Majdouline Obtel, Rachid Razine, Nour Mekaoui, L. Lahlou, Jehanne Aasfara, and Ahmed Kharbach
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medicine.medical_specialty ,Heart disease ,medicine.medical_treatment ,Prehospital delay ,Review ,030501 epidemiology ,lcsh:RC346-429 ,Brain Ischemia ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Risk Factors ,Diabetes mellitus ,Epidemiology ,medicine ,Humans ,Thrombolytic Therapy ,lcsh:Neurology. Diseases of the nervous system ,Ischemic stroke ,business.industry ,Mortality rate ,General Medicine ,Thrombolysis ,medicine.disease ,Stroke ,Trial of ORG classification 10,172 in acute stroke treatment classification ,Morocco ,Systematic review ,Sample size determination ,Emergency medicine ,Etiology ,Neurology (clinical) ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
BackgroundThe aim of this systematic review is to determine the epidemiological and etiological profiles, the influential factors of the prehospital delay, thrombolysis management, the acute and 3-month mortality rate and the genetic aspect of ischemic stroke in Morocco.MethodsThe present work is a systematic review that was conducted according to the recommendations of the “Preferred reporting items for systematic reviews and meta-analysis”. We used Pubmed, Sciencedirect, Scopus, Clinicalkey, and Google scholar databases for the raking of the gray literature during the time frame 2009 and 2018. The protocol of the review was registered in the PROSPERO register (CRD42018115206).These studies were analyzed based on: Age, sex ratio, risk factors, etiological profile according to Trial of ORG classification 10,172 in Acute Stroke Treatment, prehospital delay average and its influential factors, thrombolyzed patients’ proportion, acute and 3-month mortality and the genetic factors of ischemic stroke in Morocco.ResultsTwenty-nine (n = 29) studies were selected. The average age ranged from 49 ± 15.2 to 67.3 ± 9.9 years old. Moreover, we reported male predominance within all ages in 13 studies. High blood pressure, diabetes, smoking and heart disease were the four identified main risk factors by the prementioned studies. Atherosclerosis and cardioembolic were the main described etiologies of cerebral ischemia, and the average prehospital time ranged from 26 to 61.9 h. The proportion of thrombolysed patients ranged from 1.8% to 2.9%, the mortality rate varied in the acute phase from 3 to 13%, and the 3-month mortality ranged from 4.3 to 32.5%. It is also important to highlight that most of these studies, which were conducted in hospital environment, have a reduced sample size and no confidence interval.ConclusionsIschemic stroke is affecting more likely the young population with male predominance. Moreover, the long prehospital delay and the low proportion of thrombolysed patients are alarming. This indicates the need to investigate in depth the key factors influencing the access to care for Moroccan patients in order to improve the management of this neurologic deficit in Morocco.
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- 2019
23. Evolution of acute lower respiratory infection in children aged5 years in Morocco from 2005 to 2014
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L. Lahlou, Redouane Abouqal, Aziza Lyaghfouri, Rachid Razine, Mustapha Mrabet, Majdouline Obtel, Nada Bennani Mechita, Abdelilah Elmarnissi, and Imad Cherkaoui
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0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Joinpoint regression ,Pneumococcal conjugate vaccine ,Pneumococcal Infections ,Pneumococcal Vaccines ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,030212 general & internal medicine ,Lower respiratory infection ,Child ,Respiratory Tract Infections ,Cause of death ,business.industry ,Immunization Programs ,Incidence (epidemiology) ,Incidence ,Infant ,General Medicine ,Morocco ,030104 developmental biology ,Immunization ,Christian ministry ,business ,medicine.drug - Abstract
Acute lower respiratory infection is a major cause of death in children aged5 years in Morocco. The 13-valent pneumococcal conjugate vaccine (PCV) was introduced to the Moroccan National Immunization Programme in 2010.To investigate the trend in the incidence of acute lower respiratory infection in children aged5 years during 2005-2014 in Morocco.Data on acute lower respiratory infection in children aged5 years were obtained from the data published annually by the Moroccan Ministry of Health. We used joinpoint regression analysis to estimate the trend in incidence of acute lower respiratory infection during the study period.The incidence of acute lower respiratory infection increased significantly between 2005 and 2011: by 3.08% annually in children aged5 years and by 3.24% annually in children aged 1 to5 years. However, the incidence was stable after 2011 as the observed trends were not significant, although the incidence decreased from 2011 to 2014 by 4.26% annually in children aged5 years, by 3.57% annually in children aged 1 to5 years and by 5.14% annually in urban areas.Our results suggest a probable influence of the PCV on the trend in incidence of acute lower respiratory infection in Morocco.تطور عدوى الجهاز التنفسي السفلي الحادة في الأطفال الذين تقل أعمارهم عن 5 سنوات في المغرب في الفترة بين عامي 2005 و2014.ندى بناني مخيتا، رشيد رزين، مجدولين أوبتل، عبد الإله المرنيسي، ليلى لحلوح، عماد شرقاوي، عزيزة لغفوري، مصطفى مرابط، رضوان أبو كال.تُعتبر عدوى الجهاز التنفسي السفلي الحادة أحد الأسباب الرئيسية للوفاة في الأطفال الذين تقل أعمارهم عن 5 سنوات في المغرب. وأُدخل اللقاح المتقارن المضاد للمكونات الرئوية المكون من 13 عنصراً في البرنامج الوطني للتحصين في المغرب في عام 2010.هدفت هذه الدراسة إلى تحري الاتجاه السائد في معدل الإصابة بعدوى الجهاز التنفسي السفلي الحادة في الأطفال الذين تقل أعمارهم عن 5 سنوات في الفترة 2005-2014 في المغرب.تم الحصول على بيانات عن الإصابة بعدوى الجهاز التنفسي السفلي الحادة في الأطفال الذين تقل أعمارهم عن 5 سنوات من البيانات التي تُنشرها سنوياً وزارة الصحة المغربية. وقد استخدمنا تحليل انحدار النقط لتقدير الاتجاه السائد في معدل الإصابة بعدوى الجهاز التنفسي السفلي الحادة خلال فترة الدراسة.ارتفع معدل الإصابة بعدوى الجهاز التنفسي السفلي الحادة ارتفاعاً كبيراً في الفترة بين عامي 2005 و2011: بنسبة 3.08٪ سنوياً في الأطفال الذين تقل أعمارهم عن 5 سنوات، وبنسبة 3.24٪ سنوياً في الأطفال الذين تتراوح أعمارهم بين سنة إلى أقل من 5 سنوات. وعلى الرغم من ذلك، كان معدل الإصابة ثابتاً بعد عام 2011 ، إذ أن الاتجاهات الملحوظة لم تكن ذات أهمية، على الرغم من زيادة معدلات الإصابة من عام 2011 إلى عام 2014 بنسبة 4.26٪ سنوياً في الأطفال الذين تقل أعمارهم عن 5 سنوات، وبنسبة 3.75 ٪ سنوياً في الأطفال الذين تتراوح أعمارهم بين سنة إلى أقل من 5 سنوات، وبنسبة 5.14٪ سنوياً في المناطق الحضرية.تُشير نتائجنا إلى تأثير محتمل للقاح المتقارن المضاد للمكونات الرئوية على اتجاه معدل الإصابة بعدوى الجهاز التنفسي السفلي الحادة في المغرب.Mesure de l’évolution de l’infection aiguë respiratoire basse chez l’enfant de moins de cinq ans au Maroc de 2005 à 2014.L'infection aiguë respiratoire basse constitue une cause majeure de décès chez les enfants de moins cinq ans au Maroc. Le vaccin antipneumococcique conjugué 13-valent (VPC 13) a été introduit dans le cadre du Programme de vaccination national du Maroc en 2010.Mesurer l'évolution de l'incidence de l'infection aiguë respiratoire basse chez les enfants de moins de cinq ans durant la période comprise entre 2005 et 2014 au Maroc.Des données sur l'infection aiguë respiratoire basse chez les enfants de moins de cinq ans ont été obtenues à partir des données publiées chaque année par le ministère de la Santé marocain. Nous avons recouru à l'analyse de régression joinpoint pour estimer la tendance de l'incidence de ce type d'infections pendant la période de l'étude.L'incidence de l'infection aiguë respiratoire basse a augmenté de manière significative entre 2005 et 2011 de 3,08 % par an chez les enfants de moins de cinq ans et de 3,24 % par an chez les enfants dont l'âge était compris entre un et moins de cinq ans. Cependant, l'incidence était stable après 2011, les tendances observées n'étant pas significatives, bien que l'incidence ait diminué de 4,26 % par an entre 2011 et 2014 chez les enfants de moins de cinq ans, de 3,57 % par an chez les enfants dont l'âge était compris entre un et moins de cinq ans et de 5,14 % par an dans les zones urbaines.Nos résultats suggèrent une influence probable du VPC 13 sur l'évolution de l'incidence de l'infection aiguë respiratoire basse au Maroc.
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- 2019
24. Accident vasculaire cérébral ischémique au Maroc : délai préhospitalier et facteurs associés
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Majdouline Obtel, Rachid Razine, Ahmed Kharbach, L. Lahlou, J. Aasfara, Kenza Hassouni, and Abderrahmane Achbani
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction L’accident vasculaire cerebral ischemique est une urgence medicale et le traitement est decide en fonction de la fenetre temporelle. L’identification des facteurs influencant l’arrivee tardive a l’hopital peut contribuer a la bonne prise en charge des accidents vasculaires cerebraux ischemiques. Cette etude visait a estimer le delai pre-hospitalier et a identifier les facteurs influencant l’arivee tardive des patients ayant subi un accident vasculaire cerebral ischemique admis au centre hospitalier regional Souss Massa au Maroc. Methodes Une etude observationnelle, prospective et transversale a ete menee au centre hospitalier regional Souss Massa au Maroc. Un questionnaire a ete administre aux patients victimes d’un accident vasculaire cerebral ischemique et a des temoins (famille ou autres) au moyen d’entretiens en face a face et des donnees ont egalement ete recueillies dans les dossiers medicaux. Les analyses de regression logistique univariees et multivariees ont ete utilisees pour identifier les facteurs favorisant l’arrivee tardive au service des urgences. Resultats Au total, 197 patients qui repondaient aux criteres de l’etude ont ete inclus. Le temps median entre l’apparition des symptomes lies a l’accident vasculaire cerebral ischemique et la presentation au service des urgences etait de 6 heures (IQR, 4-16). L’analyse de regression multivariee a montre que l’analphabetisme (OR 38,58 ; IC 95 % : 3,40-437,27), l’attente de la disparition des symptomes (comportement du patient) (OR 11,24 ; IC 95 % : 1,57-80,45), la decision d’aller directement a l’hopital (comportement du patient) (OR 0,07 ; IC 95 % : 0,01-0. 57), le fait que le temoin savait que l’accident vasculaire cerebral est une maladie necessitant une prise en charge urgente et ayant une fenetre therapeutique limitee (OR 0,005 ; IC 95 % : 0,00-0,36), et l’admission directe sans reference (OR 0,005 ; IC 95 % : 0,00-0,07), etaient independamment associes a une arrivee tardive (> 4,5 heures) de patients ayant subi un accident vasculaire cerebral ischemique. Conclusion Le comportement du patient, les connaissances du temoin et l’admission directe au services des urgences pour une eventuelle prise en charge de l’accident vasculaire cerebral sont des facteurs modifiables potentiellement utiles pour reduire les delais de prise en charge, et donc augmenter les taux de mise en œuvre des therapies de reperfusion de l’accident vasculaire cerebral ischemique a la phase aigue.
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- 2021
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25. Étude de survie dans les tumeurs de vessie infiltrant le muscle vésical chez une population marocaine en 2020
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H. El Sayegh, Yassine Nouini, Ahmed Ibrahimi, Lounis Benslimane, L. Lahlou, and Idriss Ziani
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction Le cancer de la vessie est le septieme cancer diagnostique dans la population masculine dans le monde, le onzieme lorsque les deux sexes sont pris en compte. Le taux d’incidence standardise selon l’âge dans le monde (pour 100 000 personnes/an) est de 9,0 pour les hommes et de 2,2 pour les femmes. Le but de notre etude est de degager les facteurs pronostiques de la survie chez les patients traites par cystoprotatectomie pour tumeur de vessie. Methodes Etude de cohorte retro-prospective, portant sur 300 patients suivis pour une tumeur de vessie infiltrante et dont le traitement a ete une cystoprostatectomie ; l’etude comprend une phase retrospective de 10 ans, de janvier 2007 a janvier 2017 de collecte des donnees et un suivi prospectif de janvier 2017 a janvier 2020. L’etude analytique comporte une analyse univariee dans laquelle nous avons utilise des tests statistiques notamment le test Chi2 de Pearson pour la comparaison des pourcentages et le test de Student pour la comparaison de moyennes. Une analyse multi-variee a ete realisee avec le modele de regression de Cox avec un intervalle de confiance (CI) de 95 %. L’etude de survie a ete realisee selon la methode de Kaplan-Meier. Le seuil de p retenu (p Resultats La survie actuarielle a 2, 3 et 5 ans est respectivement de 83,1 %, 70,3 % et 60,6 % En analyse unifactorielle, les facteurs influencant significativement la diminution de survie globale sont : l’âge avance des patients > 65 ans, le stade T avance, le stade lymphonodal (N2, N3 versus N1) (p 70 jours, et une tumeur volumineuse (> 3 cm). Les facteurs de mauvais pronostics en cas d’atteinte ganglionnaire sur la piece de cystoprotatectomie sont : le stade lymphonodal N2 versus N1, la densite ganglionnaire positive > 20 % versus Conclusion Dans notre etude de cohorte nous avons pu soulever les facteurs de mauvais pronostics influencant defavorablement la survie globale, la survie sans recidive ainsi que les facteurs de risque de la maladie micro metastatique ganglionnaire. Ces trois parametres semblent etre determinants dans l’evolution des patients atteints de tumeur de vessie. Ils permettent aussi d’adapter la prise en charge de chaque patient en fonction des facteurs de risque et/ou de mauvais pronostic associes.
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- 2021
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26. Corrigendum to ‘Decline in childhood respiratory-related mortality after the introduction of the pneumococcal conjugate vaccine in Morocco’
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L. Lahlou, Redouane Abouqal, Mustapha Mrabet, Nada Bennani Mechita, Imad Cherkaoui, Majdouline Obtel, Aziza Lyaghfouri, Abdelilah Elmarnissi, and Rachid Razine
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medicine.medical_specialty ,Infectious Diseases ,business.industry ,Environmental health ,Public health ,Public Health, Environmental and Occupational Health ,Medicine ,General Medicine ,Respiratory system ,business ,Pneumococcal conjugate vaccine ,medicine.drug - Published
- 2021
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27. Perception du port de masque de protection par la population du sud du Maroc durant la pandémie à COVID-19
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L. Lahlou, H. Moubachir, F. Bounoua, and H. Serhane
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Pulmonary and Respiratory Medicine - Abstract
Introduction En decembre 2019, l’apparition de plusieurs cas de pneumonie atypique dans la province de Hubei en Chine a conduit a l’identification d’un nouveau corona-virus, appele SARS-CoV-2 (COVID-19). Au Maroc, apres la declaration du premier cas confirme de COVID-19, le 2 mars 2020, plusieurs mesures ont ete mises en place pour limiter la propagation du virus, dont l’utilisation des masques faciaux qui visent a limiter les projections. L’objectif de notre travail est d’evaluer les connaissances, les attitudes et les pratiques de la population generale du sud du Maroc et de decrire sa perception au port de masque. Methodes Une enquete transversale a ete menee par l’administration d’un questionnaire envoye en ligne sur les reseaux sociaux destine a la population du sud du Maroc. Resultats Parmi les 558 participants, 58,2 % etaient des hommes. L’âge moyen etait de 37,5 ± 11,17 ans. La proportion des travailleurs dans le domaine de la sante etait de 10,4 % et 19,7 % travaillaient dans le domaine de l’enseignement. La prevalence du port de masque etait de 97,8 %, et les principaux raisons du non-port de masque etaient la non-disponibilite dans 32,2 % et l’inconfort dans 22 %. Dans notre etude : seulement 32,3 % (n = 180) desinfectaient leurs mains avec la solution hydro-alcoolique avant de porter le masque, 69,2 % mettaient le masque d’une maniere a recouvrir le nez la bouche et le menton, 22,4 % placaient le masque sous le menton ou sur le front de temps en temps, 10,9 % enlevaient le masque lorsqu’il devient humide ou souille et 36,9 % l’enlevaient apres la duree d’utilisation recommandee. La perception du port de masque etait culturellement differente en fonction des regions : au sein de la population « arabo-amazigh » les gens se sentaient proteges en portant le masque et le consideraient comme une bonne habitude. D’autres n’osaient pas le porter, car c’est inhabituel dans leur conception. Les participants des villes sahariennes pensaient que le port de masque est presque la meme chose que le « NIKAB » ou « L’TAM » qu’ils mettaient pour se proteger du soleil et du sable. Une autre categorie de la population pensait que le port de masque est inutile et inefficace vue que le but du port de masque est commercial. Conclusion A la lumiere de cette etude, nous avons constate l’importance du port de masque et la meconnaissance vis-a-vis son utilisation d’ou l’interet de mener plus des compagnes de sensibilisation sur ce sujet.
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- 2021
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28. Factors of Neonatal Morbidity at the Provincial Hospital Center of Missour
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L. Lahlou, Mouna Habibi, Amina Barkat, Loubna Doukkali, Fatima Zahra Laamiri, and Nada Bennani Mechita
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Pediatrics ,medicine.medical_specialty ,Pregnancy ,030219 obstetrics & reproductive medicine ,business.industry ,Public health ,Gestational age ,Developing country ,Retrospective cohort study ,medicine.disease ,Neonatal morbidity ,03 medical and health sciences ,0302 clinical medicine ,Retrospective survey ,030225 pediatrics ,medicine ,Prospective cohort study ,business - Abstract
Background: Although neonatal mortality decreases in different regions of the world, it is still a major problem in developing countries and particularly in Morocco. Purpose: The aims of this study are to examine the characteristics of pregnant women in the hospital center in the urban commune of Missour as well as the morphological data of the newborn and identify the risk factors implicated in neonatal morbidity. Materials and Methods: A retrospective study of collected data from records of women who gave birth in the Maternity of Missour during 2012. As well as a prospective study conducted at the maternity in 2013. Results: A total of 1108 women were included in this retrospective survey, of which 45% come from areas located far from the hospital center of the province and sometimes the access is tough in winter. Only 55.1% of pregnancy was followed. Among 1121 births, 49 babies (4.3%) showed a problematic birth situation: 31 (2.7%) newborns were hospitalized in pediatrics, of which 14 are premature. Neonatal mortality rate is 0.6% that is to say 7 early deaths. The risk factors associated to neonatal morbidity are gestational age and weight birth (in 50% of the cases, 85.7% of deaths are premature infants less than 1500 g). 14 (1.2%) were referred and 11 (0.9%) malformed were noticed. The prospective study states that among the 194 women analyzed, 89.7% are housewives. 89.1% have no medical coverage and 25.4% are illiterate. Only 29.2% benefit from a blood sample during pregnancy and 50% benefit from regular ultrasound follow-up. Conclusion: Mortality and neonatal morbidity constitute a public health priority in Morocco. Our work insists on the interest of an organized support of the newborn from the community to the different levels of the health pyramid.
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- 2016
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29. The Issue of Care Given to Premature Infants in the Provincial Hospital Center of Missour
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Mouna Habibi, Loubna Doukkali, Amina Barkat, L. Lahlou, Nada Bennani Mechita, and Fatima Zahra Laamiri
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Anamnesis ,Kangaroo care ,medicine.medical_specialty ,Pediatrics ,030219 obstetrics & reproductive medicine ,Respiratory distress ,business.industry ,Mortality rate ,Retrospective cohort study ,Disease ,03 medical and health sciences ,Neonatal infection ,0302 clinical medicine ,030225 pediatrics ,Epidemiology ,Medicine ,business - Abstract
Background: Preterm birth is common in Morocco and it’s around 8%. Several management rules of taking care of preterm infants have been developed but have not been put into action. The geo-graphical inaccessibility to specialized hospitals and the weakness of the reception capacity of the care centers hinder the management of the complications associated with preterm birth. Purpose: The present study is designed to present some epidemiological data of preterm births within the Provincial Hospital Center of Missour during 2012 and to discuss the various problems emerging in the management of treatment and care. Materials and Methods: Retrospective study of preterm births in the maternity ward in the Hospital of Missour during 2012. Results: 37 preterm births among 1121 (3.3%) have been analyzed (51.3% severe premature infants, 45.9% late preterm infants and 2.7% extremely premature infants). 64.2% are originally from difficult areas to reach during winter. All mothers have received upon arrival at the maternity a corticosteroid and calcium antagonists (Adalate*) and an antibiotic treatment to those with a positive infectious anamnesis found in half of the women. We have recorded 3 twin pregnancies and 2 gravidic toxemias. Only 21 babies have been given back to their mothers (namely 56.7%). 5 premature infants (namely 13%) have been referred to the university hospital center of Fez (2 respiratory distress, a malformation and 2 severe premature births) given that there is an absence of a specialized care unit at the hospital, knowing that no baby has received neither surfactant nor caffeine at birth. 14 premature babies (namely 37.8%) have been transferred to the pediatric unit with a total death rate of 16.2% (6 premature) mainly related to neonatal infection and to suffering of the hyaline membranes disease. Conclusion: We emphasize the interest of prevention programs which demand an early diagnosis of preterm birth threats and monitoring high-risk pregnancies, improving the medical care given to low-weight premature by creating “Kangaroo” units at a regional level and the targeting of measures for rural and under-covered areas.
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- 2016
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30. Facteurs pronostiques de micro-métastase ganglionnaire des tumeurs de vessie infiltrant le muscle chez une population marocaine en 2019
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H. El Sayegh, Yassine Nouini, L. Lahlou, Lounis Benslimane, F. Saint, Ahmed Ibrahimi, Idriss Ziani, and P. De Sousa
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction Les tumeurs de vessie infiltrant le muscle (TVIM) pN+ microscopiques decouverte sur piece de cystectomie ont un pronostic tres severe avec seulement 15 a 35 % de survie a cinq ans. La chimiotherapie neoadjuvante (NAC) est conseillee avant cystectomie, elle permet de diminuer la frequence des pN+, meme si son benefice sur la mortalite specifique est inferieur a 10 % a cinq ans. Notre travail avait pour objectif d’evaluer les facteurs de risque de pN+ apres cystectomie afin de cibler precisement la population devant imperativement beneficier de la NAC. Materiel et methodes Etude observationnelle retrospective portant sur 300 patients ayant beneficies d’une cystectomie avec curage ganglionnaire pelvien (sans NAC) pour une tumeur de vessie entre janvier 2004 et juillet 2015. Tous les patients etaient consideres cN0 lors de leur evaluation preoperatoire. L’etude des facteurs pronostiques a ete faite par analyses uni- et multivariees selon le modele de Cox, incluant un risque competitif (methode de Fine et Gray ; logiciel SPSS 13.00). La survie globale a ete calculee selon la methode de Kaplan–Meier et comparees selon le test du Log rank. Resultats Un envahissement ganglionnaire etait constate chez 65 patients sur la piece de cystectomie (20 %). La survie specifique etait de 67 % a cinq ans pour les pN0 et 38 % a cinq ans pour les pN+. En analyse univariee les facteurs associes des pN+ etaient : le stade tumoral (> T3a) (p Conclusion La presence d’emboles vasculaires sur la resection precedant une cystectomie doit constituer une indication imperative de NAC.
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- 2020
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31. ENDOSCOPIC TREATMENT OF THE PLUMMER VINSON SYNDROME (PATERSON-KELLY SYNDROME): CROSS-SECTIONAL STUDY (A MOROCCAN EXPERIENCE)
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F Zehra Ajana, I Nakhcha, L Lahlou, and Imane Benelbarhdadi
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medicine.medical_specialty ,Plummer–Vinson syndrome ,Cross-sectional study ,business.industry ,General surgery ,medicine ,medicine.disease ,business ,Endoscopic treatment ,Paterson-Kelly syndrome - Published
- 2018
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32. The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission
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L. Lahlou, Bahia Belatar, Saad Kabbaj, Wajdi Maazouzi, Abdallah Elabidi, Mamoun El Faroudi, Rachid Eljaoudi, and Malika Barkiyou
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medicine.medical_specialty ,Blood transfusion ,Article Subject ,Traumatic brain injury ,medicine.medical_treatment ,chemistry.chemical_element ,Toxicology ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,lcsh:RA1190-1270 ,Internal medicine ,Ibn sina ,Medicine ,lcsh:Toxicology. Poisons ,Pharmacology ,Cadmium ,business.industry ,Heavy metals ,University hospital ,medicine.disease ,chemistry ,030220 oncology & carcinogenesis ,Mann–Whitney U test ,business ,030217 neurology & neurosurgery ,Selenium ,Research Article - Abstract
Purpose. The aim of this study is to investigate the possible role of heavy metals (lead and cadmium) and imbalance of trace elements (chromium, iron, zinc, copper, and manganese) in death among patients with severe traumatic brain injury. Material and Methods. A case-control study was conducted with 64 comatose patients with severe TBI, in the Department of Anesthesiology and Reanimation, Ibn Sina University Hospital and Hospital of Specialties in Rabat, Morocco; 22 healthy volunteers were recruited in Blood Transfusion Center of Rabat. Blood samples were collected from TBI patients, in the first week (3h after admission and each 48h during one week) and from healthy volunteers one time. Concentration of heavy metals and trace elements in serum was determined by electrochemical atomic absorption spectrometry. Statistical analysis was performed using Statistical software (SPSS) and the cases and controls were compared using the Mann–Whitney U test and Student’s t-test for cadmium according to gender and final evolution. A P-value Results. Our data showed that the difference of heavy metals concentration (lead and cadmium) between patients and healthy subjects was not statistically significant. However, the difference of some trace elements concentration (iron, copper, chromium, and selenium) between patients and healthy subjects was statistically significant. According to the final evolution, the concentration of manganese was higher in dead patients and statistically significant (p = 0.04) for heavy metals; the concentration of lead was not statistically significant while the concentration in cadmium was statistically significant (p = 0.004). By sex, lead and cadmium were statistically significant, respectively p = 0.02, p = 0.001, and cadmium was higher in women, while lead was higher in men. Conclusion. Among all studied heavy metals (lead and cadmium) and trace elements (iron, zinc, copper, selenium, chromium, and manganese), manganese and cadmium may play a role in the death of patients from severe traumatic brain injury.
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- 2018
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33. Whole-Genome Shotgun Sequences of Three Multidrug-Resistant Mycobacterium tuberculosis Strains Isolated from Morocco
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Rachid Eljaoudi, Meriem Laamarti, Yassine Ben Lahlou, Nadia El mrimar, Mohammed Frikh, Abdelhay Lemnouar, A. Zegmout, Azeddine Ibrahimi, L. Lahlou, Mohammed Amine Bendahou, Mostafa Elouennass, Tarek Alouane, Fatna Bssaibis, and N. El Hafidi
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0301 basic medicine ,Tuberculosis ,Shotgun sequencing ,Shotgun ,Biology ,medicine.disease ,biology.organism_classification ,Virology ,Contagious disease ,Mycobacterium tuberculosis ,03 medical and health sciences ,030104 developmental biology ,Genetics ,medicine ,Multidrug-Resistant Mycobacterium tuberculosis ,Prokaryotes ,Molecular Biology - Abstract
Tuberculosis is a contagious disease that usually attacks the lungs but sometimes attacks other parts of the body, such as the kidneys, glands, and bones. It is an endemic and major public health problem in Morocco. Tuberculosis is transmitted through the airways via the inhalation of microdroplets containing Mycobacterium tuberculosis . We present here the whole-genome shotgun sequences of three multidrug-resistant M. tuberculosis strains isolated from Morocco.
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- 2017
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34. First Whole-Genome Sequences of Two Multidrug-Resistant Acinetobacter baumannii Strains Isolated from a Moroccan Hospital Floor
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Hamza El Misbahi, Oussama Benhrif, Fatna Bssaibis, Souad Kartti, Mohammed Frikh, Azeddine Ibrahimi, L. Lahlou, Mostafa Elouennass, Tarek Alouane, S. Kabbage, Meriem Laamarti, Jean Uwingabiye, Soukaina El Abbassi, Abdelhay Lemnouer, Yassine Benlahlou, and Adil Maleb
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0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,biology ,Genetics ,Shotgun ,biology.organism_classification ,Multidrug resistant Acinetobacter baumannii ,Molecular Biology ,Genome ,Microbiology ,Acinetobacter baumannii - Abstract
This report describes the whole-genome shotgun sequences of two multidrug-resistant Acinetobacter baumannii strains, ABE8_07 and ABE12_M, isolated from a Moroccan hospital floor. These two genome sequences will initiate the study and characterization of the Acinetobacter baumannii genome in Morocco.
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- 2017
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35. Annotated Whole-Genome Shotgun Sequence of Multidrug-Resistant Mycobacterium tuberculosis MTB13_M Isolated from Morocco
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N. El Mrimar, Meriem Laamarti, Oussama Benhrif, A. Lemnouar, Mohammed Frikh, S. El Rarit, L. Lahlou, T. Dakka, H. El Mesbahi, Mostafa Elouennass, Tarek Alouane, H. Lemriss, A. Zegmout, Azeddine Ibrahimi, S. Karti, Adil Maleb, R. El Jaoudi, and Fatna Bssaibis
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0301 basic medicine ,Genetics ,Whole genome sequencing ,biology ,Shotgun sequencing ,biology.organism_classification ,Sputum sample ,Microbiology ,Mycobacterium tuberculosis ,03 medical and health sciences ,030104 developmental biology ,fluids and secretions ,Multidrug-Resistant Mycobacterium tuberculosis ,Prokaryotes ,Molecular Biology ,Sequence (medicine) - Abstract
Here, we describe the annotated genome sequence of Mycobacterium tuberculosis MTB13_M. The organism was isolated from a sputum sample in Morocco.
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- 2017
36. Genome Sequences of Multiresistant Staphylococcus capitis Pulsotype NRCS-A and Methicillin-Susceptible S. capitis Pulsotype NRCS-C
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S. Lemriss, H. Lemriss, S. El Kabbaj, Azeddine Ibrahimi, Patricia Martins-Simoes, Jean-Philippe Rasigade, Marine Butin, Frédéric Laurent, L. Lahlou, Yann Dumont, Department of Biotechnology Laboratory (Med-Biotech), Mohammed V University in Rabat, Département de Microbiologie Clinique [HCL Groupement Hospitalier Nord, Lyon], Hospices Civils de Lyon (HCL)-HCL Groupement Hospitalier Nord [Lyon], Laboratoire des Recherches d'Analyses Techniques et Scientifiques, Gendarmerie Royale, Pathogénie des Staphylocoques – Staphylococcal Pathogenesis (StaPath), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre National de Reference des Staphylocoques, Université de Lyon, Université Mohammed V de Rabat [Agdal] (UM5), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
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0301 basic medicine ,Strain (biology) ,Biology ,medicine.disease_cause ,biology.organism_classification ,Genome ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,3. Good health ,Microbiology ,Staphylococcus capitis ,03 medical and health sciences ,030104 developmental biology ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Genetics ,medicine ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Prokaryotes ,Molecular Biology ,Staphylococcus ,ComputingMilieux_MISCELLANEOUS - Abstract
Here, we report the draft genome sequences of methicillin-susceptible Staphylococcus captis pulsotype NCRS-C (CR02 strain) and multiresistant Staphylococcus captis pulsotype NCRS-A (CR07 strain).
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- 2016
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37. Prévalence des infections acquises à l’hôpital au Maroc : revue systématique et méta analyse
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L. Lahlou, Redouane Abouqal, Rachid Razine, Majdouline Obtel, M. Mrabet, N. Bennani Mechita, and A. Bouzian
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03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,Public Health, Environmental and Occupational Health ,060301 applied ethics ,030212 general & internal medicine ,06 humanities and the arts ,0603 philosophy, ethics and religion - Abstract
Introduction Au Maroc, l’infection acquise a l’hopital represente un reel probleme de sante publique de par sa gravite avec l’emergence de resistance et le fardeau economique cause par les couts directs et indirects engendres par l’allongement des sejours en hospitalier. L’objectif principal de cette revue systematique et meta-analyse est d’estimer la prevalence globale des infections acquises a l’hopital au Maroc a l’aide de donnees d’etudes de prevalence. Nous avons egalement etudie la variabilite de l’evolution de ces infections dans le temps. Materiel et methode Une strategie de recherche multisources utilisee pour recuperer toutes les donnees publiees sous forme texte complet ou en abstract, ainsi que celle non publiees. Les termes de recherche ont ete utilises dans les bases de donnees suivantes : Medline (PubMed), Embase, Bibliotheque Cochrane, Scopus, Science Direct, selon les thesaurus de chacune des bases de donnees, les resumes publies dans le cadre de congres ainsi que les travaux de recherche scientifique nationaux type master ou doctorat, la base de donnees de l’Organisation mondiale de la sante et « Google scholar » ainsi qu’une recherche manuelle. Deux examinateurs ont extrait et evalue les donnees independamment puis la concordance entre les deux examinateurs par le coefficient statistique Kappa (κ). La meta-analyse a ete effectuee a l’aide du logiciel Stata Statistical Software (version 14), avec un modele a effets aleatoires. Resultats Onze etudes avec 4806 patients ont ete incluses. Seule quatre etaient publiees dans de grandes bases de donnees bibliographiques le reste correspondaient a de la litterature grise. Le taux de prevalence poolee de l’IAH de toutes les etudes etait de 9,6 % (IC 95 % : 7–12,1 %). Parmi les 11 etudes, 6 ont ete menees dans des hopitaux tertiaires et les 5 autres dans des hopitaux non tertiaires. Le taux de prevalence dans les hopitaux tertiaires etait de 9,9 %(IC95 % : 6,3–13,4 %), alors qu’il etait de 9,3 % (IC95 % : 5,4–13,1 %) dans les non tertiaires ce qui etait non significativement different de celui des hopitaux tertiaires (p > 0,8). Le biais de publication evalue par Funnel Plot et par les methodes statistiques proposees par Begg et Egger ne montraient pas de biais de publication. (p > 0,05). La methode de Trim and Fill a montre que deux etudes manquaient, en les incluant la prevalence poolee etait passe a 8 %(IC95 % : 5,2–10,9 %). L’analyse en sous-groupes selon le type d’infection : l’infection urinaire nosocomiale etait en premier avec une proportion de 27,3 % (IC95 % : 14,1–40,5 %), puis l’infection du site operatoire 25,4 % (IC95 % : 17,8–33 %) enfin l’infection respiratoire basse representait 13,5 %(IC95 % : 8,4–18,7 %) des infections. La tendance d’evolution des infections IAH dans le temps a demontre une stagnation entre de 2005 a 2015 avec un beta = 0,003 et p = 0,6. Conclusion Le taux de prevalence poolee des IAH etait eleve a 9,6 % dans les hopitaux du Maroc mais peu d’etudes etaient publiees et de bonne qualite. Parmi tous les types d’infections, l’infection urinaire represente la proportion la plus elevee.
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- 2017
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38. Évolution des Infections respiratoires aiguës basses chez les enfants âgés de moins de 5 ans au Maroc
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M. Mrabet, Majdouline Obtel, Rachid Razine, L. Lahlou, Redouane Abouqal, Imad Cherkaoui, Abdelilah Elmarnissi, and N. Bennani Mechita
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction Les infections respiratoires aigues basses (IRAB) representent une importante cause de mortalite chez l’enfant âge de moins de 5 ans au Maroc. L’objectif de cette etude etait d’explorer l’evolution des IRAB chez l’enfant âge de moins de 5 ans en fonction de l’introduction du vaccin pneumococcique en 2010 dans le programme national d’immunisation au Maroc. Methodes Les donnees relatives aux IRAB chez l’enfant âge de moins de 5 ans de l’annee 2005 a l’annee 2014 ainsi que les populations cibles durant ces annees ont ete recueillies a partir des donnees publiees annuellement dans le rapport sante en chiffre du ministere de la sante Marocain. Nous avons utilise l’analyse de regression en point joint, l’annee de survenue des IRAB a ete introduite comme variable independante. Cette methode permet de detecter dans la periode d’etude, les annees associees a un changement significatif de la tendance temporelle. Le point joint correspond au meilleur moment ou la tendance de l’incidence des IRAB a change de facon significative. Cette methode permet egalement d’estimer le changement annuel en pourcentage (APC) avec son intervalle de confiance a 95 % pour chaque tendance identifiee. Dans un premier temps, nous avons realise cette analyse chez l’ensemble des enfants âges de moins de 5 ans, ensuite nous avons realise des analyses stratifiees par tranche d’âge, par milieu (rural, urbain) et par region. Les APC avant et apres le point joint ont ete representes dans les differentes regions a l’aide du logiciel micromaps. Resultats L’incidence des IRAB a augmente de facon statistiquement significative entre 2005 et 2011 (APC = 3,1 %), de 2011 a 2014 cette incidence a diminue (APC = −4,3 %) le point joint correspondait a l’annee 2011 avec un intervalle de confiance compris entre 2007 et 2012. Pour les enfants âges de moins de 1 an l’incidence a augmente en moyenne de 2,2 % annuellement de 2005 a 2011, de 2011 a 2014 cette incidence a baisse (APC = −5,6 %). Pour les enfants âges de 1 a 2 ans l’incidence a egalement augmente entre 2005 et 2011 (APC = 2,4 %) et a diminue entre 2011 et 2014 (APC = −2,4 %). Pour les enfants âges entre 2 et 5 ans l’incidence a augmente entre 2005 et 2011 (APC = 3,2 %) et a baisse entre 2011 et 2014 (APC = −4,1 %). En milieu urbain, l’incidence a augmente de 2005 a 2011 (APC = 4,3 %) et a baisse entre 2011 et 2014 (APC = −5,1 %). En milieu rural, l’incidence a augmente entre 2005 et 2011 (0,99 %) et a baisse entre 2011 et 2014 (APC = −2,8 %). Dans 10 regions sur 16 l’intervalle de confiance du point joint comprenait la periode de temps au decours de la vaccination. Conclusion La diminution de l’incidence des IRAB chez les enfants âges de moins de 5 ans coincidait avec l’introduction du vaccin pneumococcique, ceci implique une eventuelle influence de l’introduction du vaccin pneumococcique sur l’evolution des IRAB mais cette hypothese doit etre exploree par des etudes plus poussees notamment une analyse en series temporelles interrompues.
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- 2017
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39. Évaluation de l’impact de l’introduction du vaccin pneumococcique sur l’évolution de la mortalité infanto-juvénile au Maroc
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Imad Cherkaoui, Abdelilah Elmarnissi, L. Lahlou, Redouane Abouqal, Rachid Razine, M. Mrabet, N. Bennani Mechita, and M. Ob
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction Au Maroc, le niveau de mortalite infanto-juvenile a baisse de 84 en 1992 a 23,7 pour mille naissances vivantes en 2015 soit une reduction de 71 %. L’objectif de cette etude est d’analyser l’impact de l’introduction du vaccin pneumococcique en 2010 sur la reduction de la mortalite infanto-juvenile par causes respiratoires. Methodes Les taux de mortalite infanto-juvenile de 2007 a 2013 par cause respiratoire ont ete analyses a l’aide d’une analyse en series temporelles interrompues se basant sur une regression de Poisson avec correction de la surdispersion (quasi-Poisson) et en introduisant un terme de decalage (offset) egal au log de la population divise par 100 000. Les taux de mortalite par autres causes ont egalement ete analyses dans un but de comparaison. Les variables explicatives etaient le temps (en mois) ecoule depuis le debut de l’etude, un terme de vaccination egal a 0 avant la vaccination et a 1 apres son introduction, le temps (en mois) ecoule apres l’introduction de la vaccination et deux termes sinus et cosinus des mois calendaires pour ajuster sur la saisonnalite. Nous avons exclu de l’analyse l’annee suivant l’introduction de la vaccination. Nous avons ensuite realise une analyse stratifiee sur les tranches d’âge ( Resultats Durant la periode d’etude, 1334 cas de deces par cause respiratoire et 27 534 cas de deces par autres causes sont survenus chez les enfants âges de moins de 5 ans. Chez les enfants âges de moins de 1 an, 1077 cas de deces de cause respiratoire et 24 869 cas de deces d’autres causes sont survenus et chez les enfants âges entre 1 et 5 ans, 257 cas de deces de cause respiratoire et 2665 cas de deces d’autres causes sont survenus. Les taux de mortalite infanto-juvenile par cause respiratoire ont diminue de 31 % (IRR = 0,69 IC 95 % = [0,49–0,98]) durant la periode post-vaccinale de facon statistiquement significative (p = 0,004) contrairement aux taux de mortalite par autres causes (p = 0,063). Chez les enfants âges de moins de 1 an, les taux de mortalite par cause respiratoire ont diminue de 30 % (IRR = 0,70, IC 95 % = [0,50–0,96]) dans la periode post vaccinale de facon statistiquement significative (p = 0,02) contrairement aux taux de mortalite par autre causes (p = 0,135). Chez les enfants âges entre 1 et 5 ans, la diminution des taux de mortalite par cause respiratoire et autres causes dans la periode post-vaccinale etait non statistiquement significative. Conclusion La diminution des taux de mortalite infanto-juvenile dans la periode post-vaccinale est en faveur d’une efficacite vaccinale dans la prevention des infections respiratoires. L’absence de diminution des taux de mortalite par autres causes vient conforter cette hypothese.
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- 2017
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40. Management of cerebral metastases secondary to a breast cancer
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Zineb Benbrahim, L. Amaadour, Samia Arifi, Hajar Ouahbi, F.Z. El’emrabet, L. Lahlou, Nawfel Mellas, and R. Razine
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Oncology ,medicine.medical_specialty ,Breast cancer ,business.industry ,Internal medicine ,medicine ,Surgery ,General Medicine ,medicine.disease ,business - Published
- 2017
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41. High-grade superficial bladder tumors (PT1G3): Prognostic factors of recidive and progression
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L. Lahlou, R. Razine, Lounis Benslimane, Y Nouini, H. El Sayegh, Ali Iken, and Idriss Ziani
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medicine.medical_specialty ,Univariate analysis ,Urology department ,Epidemiology ,Proportional hazards model ,business.industry ,Carcinoma in situ ,Poorly differentiated ,Public Health, Environmental and Occupational Health ,Urology ,Retrospective cohort study ,medicine.disease ,Resection ,Cytology ,medicine ,business - Abstract
Introduction PT1G3 High-grade bladder tumors are superficial, poorly differentiated, they are characterized by there architectural disorganization and marked cytologic abnormalities. These tumors pose a diagnostic problem for the pathologist and a therapeutic problem for the urologist. The aim of this work is to study the predictive factors for recurrence and progression of pT1G3 bladder tumors. Material and method We undertook in this work a retrospective descriptive study, including 100 patients who were treated in the urology department between January 2010 and December 2012 at the University Hospital of Rabat (Morocco) for urothelial carcinoma classified T1G3. Rates of recurrence, progression were studied, and specific survival was done by the Kaplan–Meier method. The prognostic factors associated with this type of tumor were then investigated by Cox regression. The overall mean decline in the study was 53.7 months about 4.5 years. Results The patients were 91 (91%) men and 9 (9%) women. The average age of our patients was 58 years old with extremes ranging from 25 to 71 years old. Of the 100 patients in the study, 66 (66%) were classified T1G3 from the outset, while 34 were classified T1G3 during a recurrence (T1G3 secondary). Initial treatment consisted of deep and complete transurethral resection (RTU) in all patients. Follow-up of a BCG protocol therapy in 56 patients, among 56 (56%) patients who received BCG therapy 15 (26%) recidivated including 5 in progression, for another 44 (44%) patient group 30 (68%) recidivated, 12 of which were under progression. In univariate analysis, the significantly identified risk factors for recurrence were: tumor size > 5 cm (P = 0.01), multifocality of lesions and the lack of the adjuvant treatment to the transurethral resection of the bladder (P = 0.001) including BCG therapy. In multi-varied analysis, the significantly identified risk factors for progression and recurrence were: the presence of carcinoma in situ and the failure of BCG therapy (P = 0.001). The primary or secondary character of the tumor was not significant (P = 0.4). Thus, the difference in overall survival as a function of the initial or secondary status of T1G3 tumors was not significant when the other prognostic factors were taken into consideration. Conclusion The results of this retrospective study suggest that T1G3 tumors can be safely controlled by the RTU + BCG combination. These results justify a good deep resection followed by a second resection at 6-week intervals and intravesical BCG instillations. This study also identifies PT1G3 patients at high-risk of recurrence and progression and requires close monitoring.
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- 2018
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42. Predictive factors of failure of BCG therapy in high-level superficial bladder tumors
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Y Nouini, Lounis Benslimane, Idriss Ziani, R. Razine, H. El Sayegh, L. Lahlou, and Ali Iken
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Lamina propria ,Univariate analysis ,medicine.medical_specialty ,Epidemiology ,Proportional hazards model ,business.industry ,medicine.medical_treatment ,Public Health, Environmental and Occupational Health ,Urology ,Retrospective cohort study ,medicine.disease ,Cystectomy ,medicine.anatomical_structure ,Maintenance therapy ,Tumor progression ,medicine ,Carcinoma ,business - Abstract
Introduction High-grade bladder tumors are superficial, poorly differentiated, they are characterized by there architectural disorganization and marked cytologic abnormalities. The treatment of superficial tumors of the bladder has a twofold objective: the first one is to reduce the frequency of local recurrences and, on the second one is to prevent progression towards muscular infiltration. Hence, the indication of the adjuvant treatment to the transurethral resection of the bladder. The purpose of our work is to study the predictive factors for the failure of intravesical BCG instillations in the management of these tumors. Failure was defined by the progression or recurrence of superficial high-grade bladder tumors. Material and method We undertook in this work a retrospective descriptive study, including 80 patients who were treated in the urology department “A” at the RABAT CHU for high-grade urothelial carcinoma PTa and PT1 between January 2010 and June 2013. Rates of recurrence, progression after BCG therapy were studied. The prognostic factors associated with this type of tumor were then sought after by Cox regression. The overall average decline in the study was 50 months or about 4.5 years. Results The patients were 71 men and 9 women. The average age of our patients was 60 years old with extremes ranging from 38 to 71 years old. At 50 months, 60% of patients treated with BCG therapy are free from recurrence. This rate is 69% for PTa tumors and 53% for pT1 tumors ( P = 0.03); 22 (27%) patients had a recurrence under the same histological grade in the first 24 months, 11 (13%) patients had tumor progression, 4 of which were infiltrating cystectomy treated. In univariate analysis, the significantly identified risk factors for recurrence were: multifocal lesions ( P = 0.001), presence of associated in situ carcinoma, vascular invasion ( P P = 0.001), and the lack of maintenance therapy with BCG therapy. The risk factors for progression were: the presence of CIS, the crossing of the lamina propria especially in PT1G3 tumors, and the size greater than 5 cm. In multi-varied analysis, the presence of CIS, crossing the lamina propria and the tumor size in case of tumor PT1G3 are the significant factors of the failure of BCG therapy ( P = 0.001). The primary or secondary character of the high histological grade of tumor, patient age and multifocality ( P = 0.4) were not significant. This multi-varied study also showed a strong correlation between tumor size and invasion of the lamina propria. Conclusion The results of this retrospective study suggest that high-grade tumors must be compulsorily controlled by BCG therapy with a maintenance protocol. This study also made it possible to select patients with very high-risk of recurrence and progression after BCG therapy who should receive close monitoring and cystectomy if BCG therapy fails.
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- 2018
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43. Genome sequences of four Staphylococcus capitis NRCS-A isolates from geographically distant neonatal intensive care units
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Marine Butin, Angela Kearns, Frédéric Laurent, Jean-Philippe Rasigade, M. Deighton, L. Lahlou, Patricia Martins-Simoes, Azeddine Ibrahimi, H. Lemriss, S. El Kabbaj, Olivier Denis, and S. Lemriss
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medicine.medical_specialty ,biology ,Internal medicine ,Intensive care ,Genetics ,medicine ,MEDLINE ,Généralités ,Prokaryotes ,biology.organism_classification ,Molecular Biology ,Genome ,Staphylococcus capitis - Abstract
Staphylococcus capitis pulsotype NRCS-A was previously reported as a frequent cause of late-onset sepsis in neonatal intensive care units (NICUs) worldwide. Here, we report the whole-genome shotgun sequences of four S. capitis pulsotype NCRS-A strains, CR03, CR04, CR05, and CR09, isolated from Belgium, Australia, the United Kingdom, and France, respectively., SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2015
44. Histiocytose langerhansienne à localisation orbitaire
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L Lahlou, M Charif Chefchaouni, Amina Berraho, F. Msefer Alaoui, Z. Hajji, M. El Khorassani, and Z. Chaoui
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Gynecology ,Ophthalmology ,medicine.medical_specialty ,Histiocytosis ,Langerhans cell histiocytosis ,business.industry ,Eosinophilic granuloma ,Orbital Tumor ,medicine ,business ,medicine.disease - Abstract
But L’histiocytose a cellules de Langerhans est une pathologie rare qui represente moins de 1 % de la pathologie tumorale de l’orbite. Methodes Le cas presente ici est celui d’un garcon de 9 ans qui a presente une tumefaction inflammatoire de l’angle supero-externe de l’orbite gauche. Une tomodensitometrie a ete realisee revelant une masse tissulaire intraorbitaire a l’origine d’une osteolyse du toit de l’orbite avec extension intracrânienne. Resultats Une biopsie transpalpebrale de la tumeur realisee a mis en evidence une proliferation d’histiocytes derivant des cellules de langerhans avec, a l’etude immunohistochimique, positivite a la proteine S100 et de l’anticorps anti-CD1a, permettant la confirmation du diagnostic. Devant une augmentation rapide du volume tumoral, accompagnee d’une menace de compression du globe oculaire et de l’extension intracrânienne, il a ete instituee une chimiotherapie (vinblastine) associee a une corticotherapie. L’evolution a ete favorable. Apres un recul de deux ans, on n’a observe ni dissemination, ni recidive. Conclusion Le cas de ce patient, suivi au service d’ophtalmologie du CHU de Rabat, permet de decrire les manifestations cliniques, anathomopathologiques de l’histiocytose a cellules de Langerhans dans sa localisation orbitaire.
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- 2005
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45. A semi-analytical buckling analysis of imperfect cylindrical shells under axial compression
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Noureddine Damil, L. Lahlou, A. Limam, Mohammad Jamal, Hamid Zahrouni, M. Midani, and Michel Potier-Ferry
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Critical load ,Applied Mathematics ,Mechanical Engineering ,Numerical analysis ,Geometry ,Mechanics ,Condensed Matter Physics ,Instability ,Finite element method ,Discontinuity (linguistics) ,Bifurcation theory ,Buckling ,Mechanics of Materials ,Modeling and Simulation ,Mode coupling ,General Materials Science ,Mathematics - Abstract
In the framework of the cellular bifurcation theory, we investigate the effect of distributed and/or localized imperfections on the buckling of long cylindrical shells under axial compression. Using a double scale perturbative approach including modes interaction, we establish that the evolution of amplitudes of instability patterns is governed by a non-homogeneous second order system of three non-linear complex equations. The localized imperfections are included by employing jump conditions for their amplitude and permitting discontinuous derivatives. By solving these amplitude equations, we show the influence of distributed and/or localized imperfections on the reduction of the critical load. To assess the validity of the present method, our results are compared to those given by two finite element codes.
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- 2003
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46. Recherche de facteurs prédictifs cliniques d’une chorioamniotite histologique
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L. Lahlou, S. Alamrani, A. Barakat, Z. Alhamany, A. Malihi, Najat Lamalmi, and H. Zaidi
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Pathology and Forensic Medicine - Abstract
Introduction La chorioamniotite ou « intrauterine inflammation or infection » (Triple I) est la pathologie la plus frequente au cours de la grossesse. Elle est definie comme une inflammation aigue des membranes amniotiques, de la plaque choriale et du cordon ombilical. Objectif Rechercher s’il existe des facteurs predictifs cliniques de la chorioamniotite histologique. Materiels et methodes Examen prospectif de 50 placentas provenant de grossesses pathologiques (patientes suspectent de chorioamniotite), et 50 placentas provenant d’accouchements « normaux ». La severite de la chorioamniotite a ete classee histologiquement en fonction de l’intensite et la topographie de l’infiltrat inflammatoire (Chong Jai Kim, 2015). Les donnees cliniques maternelles, et neonatales ont ete integrees a la base de donnees. Placentas analyses par methode d’histopathologie conventionnelle (A Lhermie-Coulomb, 2005). Resultat 36/50 (72 %) des placentas de grossesses pathologiques ont montre une chorioamniotite histologique. La confrontation anatomoclinique a montre que la chorioamniotite histologique etait associee a la fievre superieure ou egale a 38 °C (90 %) ; a une rupture prematuree des membranes (RPM) remontant a plus de 12 h (60 %) ; et a des signes d’infection neonatale (55 %). Il semble exister une difference statistiquement significative (p 0,05). Dans le groupe temoins 11/50 (22 %) placentas ont montre des signes histologiques de chorioamniotite principalement de grade 1 sans funiculite. Discussion Parmi les facteurs predictifs cliniques, seule la prematurite n’a pas montre de caractere statistiquement significatif. Or la chorioamniotite est observee dans 2 a 4 % des accouchements a terme, et dans 40 a 70 % des accouchements prematures. Notre resultat serait du au faible taux de premature dans notre serie. Les consequences sur environ le quart du groupe temoins, restent a explorer. Conclusion La chorioamniotite est parfois cliniquement silencieuse. L’analyse anatomopathologique du placenta permet de la confirmer. Cette pathologie est associee de maniere predominante a une RPM superieure a 12 heures avec ou sans fievre, parfois a des signes d’infection neonatale. Le degre de severite histologique demontre les repercussions cliniques lors de l’accouchement et les consequences sur l’infection neonatale.
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- 2017
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47. Facteurs pronostiques de survie des carcinomes urothéliaux infiltrant le muscle vésical
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L. Lahlou, Yassine Nouini, H. Sayegh, Lounis Benslimane, Idriss Ziani, R. Razine, and A Iken
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction Une serie de 100 patients cystectomises sur une duree de quatre ans de janvier 2013 a decembre 2016 pour un carcinome urothelial infiltrant de vessie a ete etudiee afin d’identifier les facteurs pronostiques de survie. Patients et methodes Tous les patients ont eu une cystectomie totale avec curage ganglionnaire ilioobturateur pour tumeur maligne infiltrante de vessie. Chaque tumeur a ete classee selon la classification pTNM, leur grade tumoral, la presence ou non d’embole vasculaire, et de carcinome in situ au pourtour de la tumeur. Une chimiotherapie a ete realisee chez 40 patients (42 %) : neoadjuvante chez 31, adjuvante chez 5, neoadjuvante et adjuvante chez 4. Resultats La survie mediane moyenne de l’ensemble du groupe a ete de 14 mois, En analyse unifactorielle, les facteurs influencant de facon significative la SG ont ete le stade tumoral (T4 par rapport aux autres) avec un p p p p Conclusion Le stade tumoral, l’envahissement ganglionnaire, la presence de cis et les embols vasculaires sont les facteurs pronostiques les plus importants de la survie dans les tumeurs infiltrantes de vessie.
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- 2017
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48. Tabagisme et conduites addictives chez les étudiants de la faculté de médecine et de pharmacie de Rabat-Maroc
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K. Alaoui, A. Thimou, S. Ahid, N. Gharbi, A. Mdaghri Alaoui, L. Lahlou, and R. Razine
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction Au Maroc, l’enquete nationale en population generale sur les troubles mentaux et la toxicomanie avait estime la prevalence de consommation de toxique etait de 4,1 %, avec un taux d’abus de 3 % et un taux de dependance de l’ordre de 2,8 %. Notre etude visait a etudier le comportement tabagique des etudiants en medecine, leur degre de dependance et les facteurs qui les poussent a fumer. Etudier les autres addictions (alcool et cannabis) ainsi qu’activite physique. Methodologie Il s’agit d’une etude transversale descriptive. L’enquete s’est deroulee a la faculte de medecine et de pharmacie de Rabat a partir du debut d’avril a la fin mai 2015. Le questionnaire a ete envoye a tous les etudiants en medecine par Internet via l’outil Google Drive ce qui permettait un anonymat absolu et demander leur consentement, en expliquant les objectifs de cette enquete. Le logiciel SPSS 13,0 a ete utilise pour saisir les donnees et analyser les resultats. Les facteurs associes au tabagisme regulier chez les etudiants ont ete analyses par regression logistique unie et multivariee. La consommation d’alcool se definit par une consommation plusieurs fois par semaine au cours des 12 derniers mois, le tabagisme regulier se definit comme la consommation d’au moins une cigarette par jour, l’usage repete de cannabis c’est declarer en avoir consomme au moins 10 fois au cours des 12 derniers mois. Le test de Fagerstrom a ete utilise pour evaluer le degre de dependance chimique a la nicotine. Le test de Horn a ete utilise pour decrire le comportement tabagique et determiner les differents facteurs qui poussent a fumer. Resultats Les etudiants ayant repondu etaient 137 etudiants dont 56,5 % (78) de sexe feminin. Le pourcentage des etudiants fumeurs etait de 27 (19,7 %) (dont 85,2 % garcon contre 14,8 % des filles) l’âge de la premiere cigarette etait de 16,73 ± 2,74 ; 23 % (30) declaraient consommer de l’alcool et la consommation de cannabis de 24,2 % (32), 64 des participants pratiquaient du sport soit 48,1 %. Les facteurs initiateurs du tabagisme etaient le stress 56 % (19), l’habitude dans 8,8 % (3) et l’influence de l’entourage 35,3 % (12). Le score de dependance montrait une dependance forte chez 3,8 % des etudiants. L’evaluation des habitudes tabagiques par test de Horn rapportait les raisons suivantes : la stimulation 19 (73,1 %), la relaxation 23 (88,5 %), l’anxiete 24 (96 %), le besoin 21 (80,8 %), le plaisir gestuel 17 (68 %), et l’habitude dans 5 (18,5 %). Des tentatives anterieures d’arret ont ete retrouvees chez 52,9 % des etudiants fumeurs, 83,9 % affirmaient n’avoir recu aucune aide au sevrage et que le stress etait la cause de leur rechute dans 62,5 % (5) des cas. Les facteurs associes a la consommation reguliere de tabac etaient le sexe masculin, etre en premieres annees (1er et 2eme annee), declarer consommer de l’alcool et du cannabis. Les etudiants non−fumeurs avaient pris cette decision dans 98 %, parce qu’ils pensaient que c’etait nocif pour leur sante en general et pour la sante dentaire en particulier ; 99 % des participants affirment que le tabac est nocif pour leur entourage. Conclusion Cette enquete preliminaire pourra servir de base pour mettre en place une strategie de prevention adaptee et de point de depart pour de nouvelles recherches chez les etudiants en medecine pour mieux apprehender l’evolution des addictions dans cette population appelee a jouer un role actif en tant que futurs educateurs de sante.
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- 2017
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49. Breast cancer in young women, comparative study of 642 cases: experience of the medical oncology department CHU Hassan II FEZ, Morocco
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F.Z. El’emrabet, Samia Arifi, L. Lahlou, M. Benhami, Hajar Ouahbi, Nawfel Mellas, Zineb Benbrahim, L. Amadour, and R. Razine
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Gynecology ,medicine.medical_specialty ,Breast cancer ,business.industry ,General surgery ,medicine ,Surgery ,General Medicine ,business ,medicine.disease - Published
- 2017
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50. Evolution of Extended Spectrum Beta-Lactamase enterobacteriaceae in the Hospital Cheikh Zaid from 2009 to 2011
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A. Saadi, L. Lahlou, Mustapha Mrabet, J. Kasouati, Rachid Razine, N. Bennani Mechita, A. Benouda, and K. Sabai Idrissi
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biology ,Epidemiology ,medicine.medical_treatment ,Beta-lactamase ,medicine ,General Medicine ,biology.organism_classification ,Enterobacteriaceae ,Microbiology - Published
- 2015
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