Search

Your search keyword '"Lüscher, Thomas F."' showing total 5,325 results
Start Over Author "Lüscher, Thomas F."

Refine your results

5,325 results on '"Lüscher, Thomas F."'

1. How to make cardiology clinical trials more inclusive

Author

Zannad, Faiez, Berwanger, Otavio, Corda, Stefano, Cowie, Martin R., Gamra, Habib, Gibson, C. Michael, Goncalves, Alexandra, Hucko, Thomas, Khunti, Kamlesh, Kostrubiec, Maciej, Kraus, Bettina Johanna, Linde, Cecilia, Lüscher, Thomas F., Mafham, Marion, Mindham, Richard, Ortega, Rebecca F., Prescott, Eva, Thabane, Lehana, Yancy, Clyde, Ziegler, André, and Van Spall, Harriette G. C.

Published
2024
Full Text
View/download PDF

2. Data sharing: A new editorial initiative of the International Committee of Medical Journal Editors. Implications for the Editors´ Network

Author

Alfonso, Fernando, Adamyan, Karlen, Artigou, Jean-Yves, Aschermann, Michael, Boehm, Michael, Buendia, Alfonso, Chu, Pao-Hsien, Cohen, Ariel, Cas, Livio Dei, Dilic, Mirza, Doubell, Anton, Echeverri, Dario, Enç, Nuray, Ferreira-González, Ignacio, Filipiak, Krzysztof J., Flammer, Andreas, Fleck, Eckart, Gatzov, Plamen, Ginghina, Carmen, Goncalves, Lino, Haouala, Habib, Hassanein, Mahmoud, Heusch, Gerd, Huber, Kurt, Hulín, Ivan, Ivanusa, Mario, Krittayaphong, Rungroj, Lau, Chu-Pak, Marinskis, Germanas, Mach, François, Moreira, Luiz Felipe, Nieminen, Tuomo, Oukerraj, Latifa, Perings, Stefan, Pierard, Luc, Potpara, Tatjana, Reyes-Caorsi, Walter, Rim, Se-Joong, Rødevand, Olaf, Saade, Georges, Sander, Mikael, Shlyakhto, Evgeny, Timuralp, Bilgin, Tousoulis, Dimitris, Ural, Dilek, Piek, J. J., Varga, Albert, and Lüscher, Thomas F.

Subjects
Data sharing, Editors´ Network, International Committee of Medical Journal Editors, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship – emphasising the importance of responsibility and accountability – have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors´ Network of the European Society of Cardiology.

Published
2017
Full Text
View/download PDF

9. Biomarker-enhanced cardiovascular risk prediction in patients with cancer: a prospective cohort study

Author

Kraler, Simon, Liberale, Luca, Nopp, Stephan, Englisch, Cornelia, Grilz, Ella, Lapikova-Bryhinska, Tetiana, Akhmedov, Alexander, Carbone, Federico, Ramoni, Davide, Tirandi, Amedeo, Scuricini, Alessandro, Isoppo, Simone, Tortorella, Curzia, La Rosa, Federica, Michelauz, Cristina, Frè, Federica, Gavoci, Aurora, Lisa, Anna, Suter, Thomas M., von Eckardstein, Arnold, Wenzl, Florian A., Pabinger, Ingrid, Lüscher, Thomas F., Montecucco, Fabrizio, Ay, Cihan, and Moik, Florian

Published
2024
Full Text
View/download PDF

10. Temporal Trends in Takotsubo Syndrome: Results From the International Takotsubo Registry

Author

Schweiger, Victor, Cammann, Victoria L., Crisci, Giulia, Gilhofer, Thomas, Schlenker, Rabea, Niederseer, David, Chen, Shaojie, Ebrahimi, Ramin, Wenzl, Florian, Würdinger, Michael, Citro, Rodolfo, Vecchione, Carmine, Gili, Sebastiano, Neuhaus, Michael, Franke, Jennifer, Meder, Benjamin, Jaguszewski, Miłosz, Noutsias, Michel, Knorr, Maike, Jansen, Thomas, D’Ascenzo, Fabrizio, Dichtl, Wolfgang, von Lewinski, Dirk, Burgdorf, Christof, Kherad, Behrouz, Tschöpe, Carsten, Sarcon, Annahita, Shinbane, Jerold, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Karakas, Mahir, Koenig, Wolfgang, Pott, Alexander, Meyer, Philippe, Roffi, Marco, Banning, Adrian, Wolfrum, Mathias, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K.E. Juhani, Napp, L. Christian, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Chan, Christina, Bridgman, Paul, Beug, Daniel, Delmas, Clément, Lairez, Olivier, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, El-Battrawy, Ibrahim, Akin, Ibrahim, Poledniková, Karolina, Toušek, Petr, Winchester, David E., Massoomi, Michael, Galuszka, Jan, Ukena, Christian, Poglajen, Gregor, Carrilho-Ferreira, Pedro, Hauck, Christian, Paolini, Carla, Bilato, Claudio, Kobayashi, Yoshio, Kato, Ken, Ishibashi, Iwao, Himi, Toshiharu, Din, Jehangir, Al-Shammari, Ali, Prasad, Abhiram, Rihal, Charanjit S., Liu, Kan, Schulze, P. Christian, Bianco, Matteo, Jörg, Lucas, Rickli, Hans, Pestana, Gonçalo, Nguyen, Thanh H., Böhm, Michael, Maier, Lars S., Pinto, Fausto J., Widimský, Petr, Felix, Stephan B., Braun-Dullaeus, Ruediger C., Rottbauer, Wolfgang, Hasenfuß, Gerd, Pieske, Burkert M., Schunkert, Heribert, Budnik, Monika, Opolski, Grzegorz, Thiele, Holger, Bauersachs, Johann, Horowitz, John D., Di Mario, Carlo, Kong, William, Dalakoti, Mayank, Imori, Yoichi, Münzel, Thomas, Liberale, Luca, Montecucco, Fabrizio, Bax, Jeroen J., Crea, Filippo, Ruschitzka, Frank, Lüscher, Thomas F., Ghadri, Jelena R., Bossone, Eduardo, Templin, Christian, and Di Vece, Davide

Published
2024
Full Text
View/download PDF

12. Race- and Ethnicity-Related Differences in Heart Failure With Preserved Ejection Fraction Using Natural Language Processing

Author

Brown, Sam, Biswas, Dhruva, Wu, Jack, Ryan, Matthew, Bernstein, Brett S., Fairhurst, Natalie, Kaye, George, Baral, Ranu, Cannata, Antonio, Searle, Tom, Melikian, Narbeh, Sado, Daniel, Lüscher, Thomas F., Teo, James, Dobson, Richard, Bromage, Daniel I., McDonagh, Theresa A., Vazir, Ali, Shah, Ajay M., and O’Gallagher, Kevin

Published
2024
Full Text
View/download PDF

14. Right heart failure

Author

Lüscher, Thomas F, additional, Gorter, Thomas M, additional, Price, Susanna, additional, Riele, Anneline, additional, and Gatzoulis, Michael A, additional

Published
2023
Full Text
View/download PDF

15. Heart failure, the global pandemic: A call to action consensus statement from the global presidential conclave at the platinum jubilee conference of cardiological society of India 2023

Author

Harikrishnan, Sivadasanpillai, Rath, Prathap Chandra, Bang, Vijay, McDonagh, Theresa, Ogola, Elijah, Silva, Hugo, Rajbanshi, Bijoy G., Pathirana, Anidu, Ng, G. Andre, Biga, Cathleen, Lüscher, Thomas F., Daggubati, Ramesh, Adivi, Shirley, Roy, Debabrata, Banerjee, P.S., and Das, M.K.

Published
2024
Full Text
View/download PDF

16. Long non-coding RNAs H19 and NKILA are associated with the risk of death and lacunar stroke in the elderly population

Author

Lapikova-Bryhinska, Tetiana, Ministrini, Stefano, Puspitasari, Yustina M., Kraler, Simon, Mohamed, Shafeeq Ahmed, Costantino, Sarah, Paneni, Francesco, Khetsuriani, Michael, Bengs, Susan, Liberale, Luca, Montecucco, Fabrizio, Krampla, Wolfgang, Riederer, Peter, Hinterberger, Margareta, Fischer, Peter, Lüscher, Thomas F., Grünblatt, Edna, Akhmedov, Alexander, and Camici, Giovanni G.

Published
2024
Full Text
View/download PDF

24. Endothelial SIRT6 deficiency promotes arterial thrombosis in mice

Author

Gaul, Daniel S., Calatayud, Natacha, Pahla, Jürgen, Bonetti, Nicole R., Wang, Yu-Jen, Weber, Julien, Ambrosini, Samuele, Liberale, Luca, Costantino, Sarah, Mohammed, Shafeeq A., Kraler, Simon, Van Tits, Lambertus J., Pasterk, Lisa, Vdovenko, Daria, Akhmedov, Alexander, Ruschitzka, Frank, Paneni, Francesco, Lüscher, Thomas F., Camici, Giovanni G., and Matter, Christian M.

Published
2023
Full Text
View/download PDF

25. Mammalian Target of Rapamycin Inhibition in Patients With ST-Segment Elevation Myocardial Infarction

Author

Stähli, Barbara E., Klingenberg, Roland, Heg, Dik, Branca, Mattia, Manka, Robert, Kapos, Ioannis, Müggler, Oliver, Denegri, Andrea, Kesterke, Rahel, Berger, Florence, Stehli, Julia, Candreva, Alessandro, von Eckardstein, Arnold, Carballo, David, Hamm, Christian, Landmesser, Ulf, Mach, François, Moccetti, Tiziano, Jung, Christian, Kelm, Malte, Münzel, Thomas, Pedrazzini, Giovanni, Räber, Lorenz, Windecker, Stephan, Templin, Christian, Matter, Christian M., Lüscher, Thomas F., and Ruschitzka, Frank

Published
2022
Full Text
View/download PDF

26. CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research

Author

Kotecha, Dipak, Asselbergs, Folkert W, Achenbach, Stephan, Anker, Stefan D, Atar, Dan, Baigent, Colin, Banerjee, Amitava, Beger, Birgit, Brobert, Gunnar, Casadei, Barbara, Ceccarelli, Cinzia, Cowie, Martin R, Crea, Filippo, Cronin, Maureen, Denaxas, Spiros, Derix, Andrea, Fitzsimons, Donna, Fredriksson, Martin, Gale, Chris P, Gkoutos, Georgios V, Goettsch, Wim, Hemingway, Harry, Ingvar, Martin, Jonas, Adrian, Kazmierski, Robert, Løgstrup, Susanne, Lumbers, R Thomas, Lüscher, Thomas F, McGreavy, Paul, Piña, Ileana L, Roessig, Lothar, Steinbeisser, Carl, Sundgren, Mats, Tyl, Benoît, Thiel, Ghislaine van, Bochove, Kees van, Vardas, Panos E, Villanueva, Tiago, Vrana, Marilena, Weber, Wim, Weidinger, Franz, Windecker, Stephan, Wood, Angela, and Grobbee, Diederick E

Published
2022
Full Text
View/download PDF

28. Sex-specific evaluation and redevelopment of the GRACE score in non-ST-segment elevation acute coronary syndromes in populations from the UK and Switzerland: a multinational analysis with external cohort validation

Author

Wenzl, Florian A, Kraler, Simon, Ambler, Gareth, Weston, Clive, Herzog, Sereina A, Räber, Lorenz, Muller, Olivier, Camici, Giovanni G, Roffi, Marco, Rickli, Hans, Fox, Keith A A, de Belder, Mark, Radovanovic, Dragana, Deanfield, John, and Lüscher, Thomas F

Published
2022
Full Text
View/download PDF

31. Controlled-Level EVERolimus in Acute Coronary Syndrome (CLEVER-ACS) - A phase II, randomized, double-blind, multi-center, placebo-controlled trial

Author

Klingenberg, Roland, Stähli, Barbara E., Heg, Dik, Denegri, Andrea, Manka, Robert, Kapos, Ioannis, von Eckardstein, Arnold, Carballo, David, Hamm, Christian W., Vietheer, Julia, Rolf, Andreas, Landmesser, Ulf, Mach, François, Moccetti, Tiziano, Jung, Christian, Kelm, Malte, Münzel, Thomas, Pedrazzini, Giovanni, Räber, Lorenz, Windecker, Stephan, Matter, Christian M., Ruschitzka, Frank, and Lüscher, Thomas F.

Published
2022
Full Text
View/download PDF

33. Artificial intelligence in cardiovascular medicine: clinical applications.

Author

Lüscher, Thomas F, Wenzl, Florian A, D'Ascenzo, Fabrizio, Friedman, Paul A, and Antoniades, Charalambos

Subjects
MACHINE learning, HUMAN facial recognition software, ARTIFICIAL intelligence, DEEP learning, PHENOTYPIC plasticity
Abstract

Clinical medicine requires the integration of various forms of patient data including demographics, symptom characteristics, electrocardiogram findings, laboratory values, biomarker levels, and imaging studies. Decision-making on the optimal management should be based on a high probability that the envisaged treatment is appropriate, provides benefit, and bears no or little potential harm. To that end, personalized risk–benefit considerations should guide the management of individual patients to achieve optimal results. These basic clinical tasks have become more and more challenging with the massively growing data now available; artificial intelligence and machine learning (AI/ML) can provide assistance for clinicians by obtaining and comprehensively preparing the history of patients, analysing face and voice and other clinical features, by integrating laboratory results, biomarkers, and imaging. Furthermore, AI/ML can provide a comprehensive risk assessment as a basis of optimal acute and chronic care. The clinical usefulness of AI/ML algorithms should be carefully assessed, validated with confirmation datasets before clinical use, and repeatedly re-evaluated as patient phenotypes change. This review provides an overview of the current data revolution that has changed and will continue to change the face of clinical medicine radically, if properly used, to the benefit of physicians and patients alike. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

36. Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry

Author

Imori, Yoichi, Kato, Ken, Cammann, Victoria L., Szawan, Konrad A., Wischnewsky, Manfred, Dreiding, Sara, Würdinger, Michael, Schönberger, Maximilian, Petkova, Vanya, Niederseer, David, Levinson, Rena A., Di Vece, Davide, Gili, Sebastiano, Seifert, Burkhardt, Wakita, Masaki, Suzuki, Noriko, Citro, Rodolfo, Bossone, Eduardo, Heiner, Susanne, Knorr, Maike, Jansen, Thomas, Münzel, Thomas, D’Ascenzo, Fabrizio, Franke, Jennifer, Sorici-Barb, Ioana, Katus, Hugo A., Sarcon, Annahita, Shinbane, Jerold, Napp, L. Christian, Bauersachs, Johann, Jaguszewski, Milosz, Shiomura, Reiko, Nakamura, Shunichi, Takano, Hitoshi, Noutsias, Michel, Burgdorf, Christof, Ishibashi, Iwao, Himi, Toshiharu, Koenig, Wolfgang, Schunkert, Heribert, Thiele, Holger, Kherad, Behrouz, Tschöpe, Carsten, Pieske, Burkert M., Rajan, Lawrence, Michels, Guido, Pfister, Roman, Mizuno, Shingo, Cuneo, Alessandro, Jacobshagen, Claudius, Hasenfuß, Gerd, Karakas, Mahir, Mochizuki, Hiroki, Pott, Alexander, Rottbauer, Wolfgang, Said, Samir M., Braun-Dullaeus, Ruediger C., Banning, Adrian, Isogai, Toshiaki, Kimura, Akihisa, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Tomita, Yasuhiro, Budnik, Monika, Opolski, Grzegorz, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Crea, Filippo, Dichtl, Wolfgang, Murakami, Tsutomu, Ikari, Yuji, Empen, Klaus, Beug, Daniel, Felix, Stephan B., Delmas, Clément, Lairez, Olivier, Yamaguchi, Tetsuo, El-Battrawy, Ibrahim, Akin, Ibrahim, Borggrefe, Martin, Horowitz, John D., Kozel, Martin, Tousek, Petr, Widimský, Petr, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, Neuhaus, Michael, Meyer, Philippe, Arroja, Jose David, Chan, Christina, Bridgman, Paul, Galuszka, Jan, Poglajen, Gregor, Carrilho-Ferreira, Pedro, Pinto, Fausto J., Hauck, Christian, Maier, Lars S., Liu, Kan, Di Mario, Carlo, Paolini, Carla, Bilato, Claudio, Bianco, Matteo, Jörg, Lucas, Rickli, Hans, Winchester, David E., Ukena, Christian, Böhm, Michael, Bax, Jeroen J., Prasad, Abhiram, Rihal, Charanjit S., Saito, Shigeru, Kobayashi, Yoshio, Lüscher, Thomas F., Ruschitzka, Frank, Shimizu, Wataru, Ghadri, Jelena R., and Templin, Christian

Published
2022
Full Text
View/download PDF

37. Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk

Author

Li, Xinmin S, Wang, Zeneng, Cajka, Tomas, Buffa, Jennifer A, Nemet, Ina, Hurd, Alex G, Gu, Xiaodong, Skye, Sarah M, Roberts, Adam B, Wu, Yuping, Li, Lin, Shahen, Christopher J, Wagner, Matthew A, Hartiala, Jaana A, Kerby, Robert L, Romano, Kymberleigh A, Han, Yi, Obeid, Slayman, Lüscher, Thomas F, Allayee, Hooman, Rey, Federico E, DiDonato, Joseph A, Fiehn, Oliver, Tang, WH Wilson, and Hazen, Stanley L

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Prevention, Heart Disease, Nutrition, Cardiovascular, Good Health and Well Being, Aged, Animals, Atherosclerosis, Cardiovascular Diseases, Carnitine, Cholesterol, Choline, Disease Models, Animal, Feces, Female, Gastrointestinal Microbiome, Genome-Wide Association Study, Humans, Lysine, Male, Metabolomics, Methylamines, Mice, Mice, Inbred C57BL, Middle Aged, Nutrients, Risk Factors, Thrombosis, Cardiology, Cardiovascular disease, Vascular Biology, Biomedical and clinical sciences, Health sciences
Abstract

Using an untargeted metabolomics approach in initial (N = 99 subjects) and replication cohorts (N = 1,162), we discovered and structurally identified a plasma metabolite associated with cardiovascular disease (CVD) risks, N6,N6,N6-trimethyl-L-lysine (trimethyllysine, TML). Stable-isotope-dilution tandem mass spectrometry analyses of an independent validation cohort (N = 2,140) confirmed TML levels are independently associated with incident (3-year) major adverse cardiovascular event risks (hazards ratio [HR], 2.4; 95% CI, 1.7-3.4) and incident (5-year) mortality risk (HR, 2.9; 95% CI, 2.0-4.2). Genome-wide association studies identified several suggestive loci for TML levels, but none reached genome-wide significance; and d9(trimethyl)-TML isotope tracer studies confirmed TML can serve as a nutrient precursor for gut microbiota-dependent generation of trimethylamine (TMA) and the atherogenic metabolite trimethylamine N-oxide (TMAO). Although TML was shown to be abundant in both plant- and animal-derived foods, mouse and human fecal cultures (omnivores and vegans) showed slow conversion of TML to TMA. Furthermore, unlike chronic dietary choline, TML supplementation in mice failed to elevate plasma TMAO or heighten thrombosis potential in vivo. Thus, TML is identified as a strong predictor of incident CVD risks in subjects and to serve as a dietary precursor for gut microbiota-dependent generation of TMAO; however, TML does not appear to be a major microbial source for TMAO generation in vivo.

Published
2018

39. Inhibition of de novo ceramide synthesis by Sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes

Author

Velagapudi, Srividya, primary, Karsai, Gergely, additional, Karsai, Maria, additional, Mohammed, Shafeeq A, additional, Montecucco, Fabrizio, additional, Liberale, Luca, additional, Lee, Hwan, additional, Carbone, Federico, additional, Francesco Adami, Giovanni, additional, Yang, Kangmin, additional, Crucet, Margot, additional, Stein, Sokrates, additional, Paneni, Franceso, additional, Lapikova-Bryhinska, Tetiana, additional, Jang, Hyun-Duk, additional, Kraler, Simon, additional, Vdovenko, Daria, additional, Arnold Züllig, Richard, additional, Camici, Giovanni G, additional, Kim, Hyo-Soo, additional, Laaksonen, Reijo, additional, Gerber, Philipp A, additional, Hornemann, Thorsten, additional, Akhmedov, Alexander, additional, and Lüscher, Thomas F, additional

Published
2024
Full Text
View/download PDF

40. Cardiac biomarkers for diagnosing Takotsubo syndrome

Author

Schweiger, Victor, primary, Di Vece, Davide, additional, Cammann, Victoria L, additional, Koleva, Iva, additional, Würdinger, Michael, additional, Gilhofer, Thomas, additional, Rajman, Katja, additional, Szawan, Konrad A, additional, Niederseer, David, additional, Citro, Rodolfo, additional, Vecchione, Carmine, additional, Bossone, Eduardo, additional, Gili, Sebastiano, additional, Neuhaus, Michael, additional, Franke, Jennifer, additional, Meder, Benjamin, additional, Jaguszewski, Miłosz, additional, Noutsias, Michel, additional, Knorr, Maike, additional, Jansen, Thomas, additional, D’Ascenzo, Fabrizio, additional, Bruno, Francesco, additional, De Filippo, Ovidio, additional, Stefanini, Giulio, additional, Campo, Gianluca, additional, Wanha, Wojciech, additional, Roubin, Sergio Raposeiras, additional, Dichtl, Wolfgang, additional, von Lewinski, Dirk, additional, Burgdorf, Christof, additional, Kherad, Behrouz, additional, Tschöpe, Carsten, additional, Sarcon, Annahita, additional, Shinbane, Jerold, additional, Rajan, Lawrence, additional, Michels, Guido, additional, Pfister, Roman, additional, Cuneo, Alessandro, additional, Jacobshagen, Claudius, additional, Karakas, Mahir, additional, Koenig, Wolfgang, additional, Pott, Alexander, additional, Meyer, Philippe, additional, Roffi, Marco, additional, Banning, Adrian, additional, Wolfrum, Mathias, additional, Cuculi, Florim, additional, Kobza, Richard, additional, Fischer, Thomas A, additional, Vasankari, Tuija, additional, Airaksinen, K E Juhani, additional, Napp, L Christian, additional, Dworakowski, Rafal, additional, MacCarthy, Philip, additional, Kaiser, Christoph, additional, Osswald, Stefan, additional, Galiuto, Leonarda, additional, Chan, Christina, additional, Bridgman, Paul, additional, Beug, Daniel, additional, Delmas, Clément, additional, Lairez, Olivier, additional, Gilyarova, Ekaterina, additional, Shilova, Alexandra, additional, Gilyarov, Mikhail, additional, El-Battrawy, Ibrahim, additional, Akin, Ibrahim, additional, Poledniková, Karolina, additional, Toušek, Petr, additional, Winchester, David E, additional, Massoomi, Michael, additional, Galuszka, Jan, additional, Ukena, Christian, additional, Poglajen, Gregor, additional, Carrilho-Ferreira, Pedro, additional, Hauck, Christian, additional, Paolini, Carla, additional, Bilato, Claudio, additional, Kobayashi, Yoshio, additional, Kato, Ken, additional, Ishibashi, Iwao, additional, Himi, Toshiharu, additional, Din, Jehangir, additional, Al-Shammari, Ali, additional, Prasad, Abhiram, additional, Rihal, Charanjit S, additional, Liu, Kan, additional, Schulze, P Christian, additional, Bianco, Matteo, additional, Jörg, Lucas, additional, Rickli, Hans, additional, Pestana, Gonçalo, additional, Nguyen, Thanh H, additional, Böhm, Michael, additional, Maier, Lars S, additional, Pinto, Fausto J, additional, Widimský, Petr, additional, Felix, Stephan B, additional, Braun-Dullaeus, Ruediger C, additional, Rottbauer, Wolfgang, additional, Hasenfuß, Gerd, additional, Pieske, Burkert M, additional, Schunkert, Heribert, additional, Budnik, Monika, additional, Opolski, Grzegorz, additional, Thiele, Holger, additional, Bauersachs, Johann, additional, Horowitz, John D, additional, Di Mario, Carlo, additional, Kong, William, additional, Dalakoti, Mayank, additional, Imori, Yoichi, additional, Münzel, Thomas, additional, Bax, Jeroen J, additional, Lüscher, Thomas F, additional, Crea, Filippo, additional, Ruschitzka, Frank, additional, Ghadri, Jelena R, additional, and Templin, Christian, additional

Published
2024
Full Text
View/download PDF

42. Safety and effectiveness of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: insights from the SPUM-ACS study

Author

Bruno, Francesco, primary, Wenzl, Florian A, additional, De Filippo, Ovidio, additional, Kraler, Simon, additional, Giacobbe, Federico, additional, Roffi, Marco, additional, Muller, Olivier, additional, Räber, Lorenz, additional, Templin, Christian, additional, Maria De Ferrari, Gaetano, additional, D'Ascenzo, Fabrizio, additional, and Lüscher, Thomas F, additional

Published
2024
Full Text
View/download PDF

49. Global position paper on cardiovascular regenerative medicine

Author

Fernández-Avilés, Francisco, Sanz-Ruiz, Ricardo, Climent, Andreu M, Badimon, Lina, Bolli, Roberto, Charron, Dominique, Fuster, Valentin, Janssens, Stefan, Kastrup, Jens, Kim, Hyo-Soo, Lüscher, Thomas F, Martin, John F, Menasché, Philippe, Simari, Robert D, Stone, Gregg W, Terzic, Andre, Willerson, James T, Wu, Joseph C, Group, the TACTICS Writing, Broughton, Kathleen, DiFede, Darcy L, Dimmeler, Stefanie, Madonna, Rosalinda, Penn, Marc S, Sussman, Mark A, Sluijter, Joost PG, Wollert, Kai C, Balkan, Wayne, Chamuleau, Steven, Fernández-Santos, María Eugenia, Goliasch, Georg, Gyöngyösi, Mariann, Hare, Joshua M, Tompkins, Bryon A, Winkler, Johannes, Bayés-Genís, Antoni, Henry, Timothy D, Taylor, Doris A, Lerman, Amir, Pelacho, Beatriz, Prosper, Felipe, Perin, Emerson C, Pompilio, Giulio, Gersh, Bernard, Bartunek, Jozef, Duckers, Eric, Ferdinandy, Péter, Losordo, Douglas W, Sánchez, Pedro L, Sherman, Warren, Wojakowski, Wojtek, Zeiher, Andreas, Roncalli, Jerome, Mathur, Anthony, Crea, Filippo, D´Amario, Domenico, Povsic, Thomas J, Traverse, Jay, and Ylä-Herttuala, Seppo

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cardiovascular Diseases, Consensus, Humans, Precision Medicine, Regenerative Medicine, TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) Writing Group, Authors/Task Force Members. Chairpersons, Basic Research Subcommittee, Translational Research Subcommittee, Challenges of Cardiovascular Regenerative Medicine Subcommittee, Tissue Engineering Subcommittee, Delivery, Navigation, Tracking and Assessment Subcommittee, Clinical Trials Subcommittee, Regulatory and funding strategies subcommittee, Delivery, Navigation, Tracking and Assessment Subcommittee, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Published
2017

50. Body temperature, systemic inflammation and risk of adverse events in patients with acute coronary syndromes.

Author

van der Stouwe, Jan Gerrit, Godly, Konstantin, Kraler, Simon, Godly, Julia, Matter, Christian M., Wenzl, Florian A., von Eckardstein, Arnold, Räber, Lorenz, Mach, François, Obeid, Slayman, Templin, Christian, Lüscher, Thomas F., and Niederseer, David

Abstract

Background: Inflammatory processes can trigger acute coronary syndromes (ACS) which may increase core body temperature (BT), a widely available low‐cost marker of systemic inflammation. Herein, we aimed to delineate baseline characteristics of ST‐segment elevation myocardial infarction (STEMI) and non‐ST‐segment elevation ACS (NSTE‐ACS) patients stratified by initial BT and to assess its predictive utility towards major adverse cardiovascular events (MACE) after the index ACS. Methods: From 2012 until 2017, a total of 1044 ACS patients, 517 with STEMI and 527 with NSTE‐ACS, were prospectively recruited at the University Hospital Zurich. BT was measured by digital tympanic thermometer along with high‐sensitivity C‐reactive protein (hs‐CRP) and cardiac troponin‐T (hs‐cTnT) levels prior to coronary angiography. Patients were stratified according to initial BT and uni‐ and multivariable regression models were fit to assess associations of BT with future MACE risk. Results: Among patients with STEMI, BT was not predictive of 1‐year MACE, but a U‐shaped relationship between BT and MACE risk was noted in those with NSTE‐ACS (p =.029), translating into a 2.4‐fold (HR, 2.44, 95% CI, 1.16–5.16) increased 1‐year MACE risk in those with BT >36.8°C (reference: 36.6–36.8°C). Results remained robust in multivariable‐adjusted analyses accounting for sex, age, diabetes, renal function and hs‐cTnT. However, when introducing hs‐CRP, the BT‐MACE association did not prevail. Conclusions: In prospectively recruited patients with ACS, initial BT shows a U‐shaped relationship with 1‐year MACE risk among those with NSTE‐ACS, but not in those with STEMI. BT is a broadly available low‐cost marker to identify ACS patients with high inflammatory burden, at high risk for recurrent ischaemic events, and thus potentially suitable for an anti‐inflammatory intervention. Registration: ClinicalTrials.gov Identifier: NCT01000701. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results