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Your search keyword '"Lü, He-Zuo"' showing total 167 results
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167 results on '"Lü, He-Zuo"'

3. IL-11 Plays a Protective Anti-Inflammatory Role in Spinal Cord Injury by Inhibiting Microglial Activation Through Suppression of ISG15 Signaling

Author

Sun, Yang, primary, Geng, Zhijun, additional, Xue, Song, additional, Xiao, Linyu, additional, Xu, Yibo, additional, Wang, Zhiyuan, additional, Liu, Xinyue, additional, Li, Jing, additional, Wang, Lian, additional, Wang, Yueyue, additional, Zhang, Xiaofeng, additional, Zuo, Lugen, additional, Lü, He-Zuo, additional, and Hu, Jian-Guo, additional

Published
2024
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7. The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis

Author

Li, Jing-Lu, primary, Fu, Gui-Qiang, additional, Wang, Yang-Yang, additional, Bian, Ming-Ming, additional, Xu, Yao-Mei, additional, Zhang, Lin, additional, Chen, Yu-Qing, additional, Zhang, Nan, additional, Ding, Shu-Qin, additional, Wang, Rui, additional, Fang, Rui, additional, Tang, Jie, additional, Hu, Jian-Guo, additional, and Lü, He-Zuo, additional

Published
2023
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23. Feature article: Neuroprotective effects of P7C3 against spinal cord injury in rats

Author

Duan, Fei-Xiang, Shi, Yu-Jiao, Chen, Jing, Ding, Shu-Qin, Wang, Feng-Chao, Tang, Jie, Wang, Rui, Shen, Lin, Xi, Jin, Qi, Qi, Lü, He-Zuo, and Hu, Jian-Guo

Subjects
Neurons, Rats, Sprague-Dawley, Oligodendroglia, Neuroprotective Agents, Spinal Cord, Carbazoles, Animals, Female, Motor Activity, NAD, Spinal Cord Injuries, Original Research, Rats
Abstract

Spinal cord injury (SCI), a serious neurological disease, has few therapeutic interventions. A small molecule, P7C3, has been confirmed to play a role in neuroprotection of some neurological diseases. But the effect of P7C3 on acute SCI has not been investigated. Here, we observed the therapeutic effect of P7C3 for alleviating the neurological damage by direct subcutaneous injection after SCI once daily for 7 or 14 days in a rat model. The locomotion and histopathological changes were evaluated. Our results demonstrated that P7C3 treatment contributed to functional recovery and tissue repair following SCI. Improved locomotor function with P7C3 treatment was correlated with increased survival of neurons and oligodendrocytes (OLs) and proliferation of OLs and their progenitors, which resulted in tissue repair and myelination in the injured SC. P7C3 treatment also restored the nicotinamide adenine dinucleotide level in the SC, which was reduced by SCI. These results suggest that P7C3 plays a role in improving neurological outcome following SCI. IMPACT STATEMENT: Spinal cord injury (SCI), a serious neurological disease, has few therapeutic interventions. This study confirms for the first time that P7C3 is conducive to functional recovery and tissue repair after SCI. P7C3 treatment can rescue the nicotinamide adenine dinucleotide level of the injured spinal cord, which results in more survival of neurons and oligodendrocytes (OLs) and proliferation of OLs and their progenitors, and thus increase myelination and tissue repair. This result indicates that P7C3 plays a role in improving neurological outcome following SCI.

Published
2019

28. Neuroprotective effects of P7C3 against spinal cord injury in rats

Author

Duan, Fei-Xiang, primary, Shi, Yu-Jiao, additional, Chen, Jing, additional, Ding, Shu-Qin, additional, Wang, Feng-Chao, additional, Tang, Jie, additional, Wang, Rui, additional, Shen, Lin, additional, Xi, Jin, additional, Qi, Qi, additional, Lü, He-Zuo, additional, and Hu, Jian-Guo, additional

Published
2019
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35. Cyclosporin A increases recovery after spinal cord injury but does not improve myelination by oligodendrocyte progenitor cell transplantation

Author

Wang Feng-Chao, Zhou Jian-Sheng, Wang Yan-Xia, Lü He-Zuo, and Hu Jian-Guo

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Abstract Background Transplantation of oligodendrocyte precursor cells (OPCs) is an attractive therapy for demyelinating diseases. Cyclosporin A (CsA) is one of the foremost immunosuppressive agents and has widespread use in tissue and cell transplantation. However, whether CsA affects survival and differentiation of engrafted OPCs in vivo is unknown. In this study, the effect of CsA on morphological, functional and immunological aspects, as well as survival and differentiation of engrafted OPCs in injured spinal cord was explored. Results We transplanted green fluorescent protein (GFP) expressed OPCs (GFP-OPCs) into injured spinal cords of rats treated with or without CsA (10 mg/kg). Two weeks after cell transplantation, more GFP-positive cells were found in CsA-treated rats than that in vehicle-treated ones. However, the engrafted cells mostly differentiated into astrocytes, but not oligodendrocytes in both groups. In the CsA-treated group, a significant decrease in spinal cord lesion volume along with increase in spared myelin and neurons were found compared to the control group. Such histological improvement correlated well with an increase in behavioral recovery. Further study suggested that CsA treatment could inhibit infiltration of T cells and activation of resident microglia and/or macrophages derived from infiltrating monocytes in injured spinal cords, which contributes to the survival of engrafted OPCs and repair of spinal cord injury (SCI). Conclusions These results collectively indicate that CsA can promote the survival of engrafted OPCs in injured spinal cords, but has no effect on their differentiation. The engrafted cells mostly differentiated into astrocytes, but not oligodendrocytes. The beneficial effect of CsA on SCI and the survival of engrafted cells may be attributed to its neuroprotective effect.

Published
2010
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36. Chondroitin sulfate proteoglycans regulate the growth, differentiation and migration of multipotent neural precursor cells through the integrin signaling pathway

Author

Lü He-Zuo, Li Ying, Wang Yan-Xia, Fu Sai-Li, Gu Wen-Li, Xu Xiao-Ming, and Lu Pei-Hua

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Abstract Background Neural precursor cells (NPCs) are defined by their ability to proliferate, self-renew, and retain the potential to differentiate into neurons and glia. Deciphering the factors that regulate their behaviors will greatly aid in their use as potential therapeutic agents or targets. Chondroitin sulfate proteoglycans (CSPGs) are prominent components of the extracellular matrix (ECM) in the central nervous system (CNS) and are assumed to play important roles in controlling neuronal differentiation and development. Results In the present study, we demonstrated that CSPGs were constitutively expressed on the NPCs isolated from the E16 rat embryonic brain. When chondroitinase ABC was used to abolish the function of endogenous CSPGs on NPCs, it induced a series of biological responses including the proliferation, differentiation and migration of NPCs, indicating that CSPGs may play a critical role in NPC development and differentiation. Finally, we provided evidence suggesting that integrin signaling pathway may be involved in the effects of CSPGs on NPCs. Conclusion The present study investigating the influence and mechanisms of CSPGs on the differentiation and migration of NPCs should help us to understand the basic biology of NPCs during CNS development and provide new insights into developing new strategies for the treatment of the neurological disorders in the CNS.

Published
2009
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