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1. Diagnosis and treatment of pancreatic duct disruption or disconnection: an international expert survey and case vignette study

Author

Albert, J., Arvanitakis, M., Badaoui, A., Barthet, M., van Biervliet, G., Bradley, E., Boermeester, M., Buchler, M., Cappendijk, V., Charnley, R., Connor, S., Dejong, C., Dellinger, P., Dervenis, C., Deviere, J., Dumonceau, J., van Eijck, C., Fagenholz, P., Castillo, C.Fernandez-del, Forsmark, C., Freeman, M., French, J., van Goor, H., Haveman, J.W., van Hooft, J., Hucl, T., Isaji, S., Jagielski, M., Karjula, H., Lerch, M., Lévy, P., Lillemoe, K., Löhr, M., Mayerle, J., Mittal, A., Morgan, D., Moon, S., Nieuwenhuijs, V., Sarr, M., Seewald, S., Sherman, S., Singh, V., Siriwardena, A., Stommel, M., Tann, M., Téllez-Avina, F., Timmer, R., Traverso, W., Radenkovic, D., Rana, S., Rebours, V., Pelaez-Luna, M., Poley, J.W., Windsor, J., Zaheer, A., Zyromski, N., Boxhoorn, Lotte, Timmerhuis, Hester C., Verdonk, Robert C., Besselink, Marc G., Bollen, Thomas L., Bruno, Marco J., Elmunzer, B. Joseph, Fockens, Paul, Horvath, Karen D., van Santvoort, Hjalmar C., and Voermans, Rogier P.

Published
2021
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4. Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study

Author

Rosato, V., Gómez-Rubio, P., Molina-Montes, E., Márquez, M., Löhr, M., O’Rorke, M., Michalski, C. W., Molero, X., Farré, A., Perea, J., Kleeff, J., Crnogorac-Jurcevic, T., Greenhalf, W., Ilzarbe, L., Tardón, A., Gress, T., Barberá, V. M., Domínguez-Muñoz, E., Muñoz-Bellvís, L., Balsells, J., Costello, E., Iglesias, M., Kong, Bo, Mora, J., O’Driscoll, D., Poves, I., Scarpa, A., Ye, W., Hidalgo, M., Sharp, L., Carrato, A., Real, F. X., La Vecchia, C., and Malats, N.

Published
2021
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13. BRMS1 in gliomas – an expression analysis

Author

Feldheim, JJ, Feldheim, J, Keßler, AF, Glas, M, Ernestus, RI, Monoranu, CM, Löhr, M, and Hagemann, C

Subjects
ddc: 610, Medicine and health, nervous system diseases
Abstract

Objective: Glioblastoma multiforme (GBM) is the most common malignant primary tumor of the central nervous system. Up to this day, patients diagnosed with GBM face an unfavorable prognosis, even with the intense standard treatment consisting of surgical resection, radiation and chemotherapy. Therefore, [for full text, please go to the a.m. URL]

Published
2022
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14. Licochalcone A – an ADAM9 inhibitor for vestibular schwannoma therapy

Author

Flock, K, Matthies, C, Ernestus, RI, Löhr, M, Hagemann, C, and Breun, M

Subjects
ddc: 610, Medicine and health, otorhinolaryngologic diseases
Abstract

Objective: Recently, we described a disintegrin and metalloproteinase 9 (ADAM9) overexpression by Schwann cells of vestibular schwannoma (VS) and suggested that it might be a marker for VS tumor growth and invasiveness. Consequently, we analyzed the effect of Licochalcone A (LicA), an ADAM9 inhibitor, [for full text, please go to the a.m. URL]

Published
2022
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15. Tumour Treating Fields (TTFields) promotes Rho kinase-dependent phosphorylation of the tight junction protein claudin-5

Author

Salvador, E, Keßler, AF, Burek, M, Tempel Brami, C, Voloshin-Sela, T, Volodin, A, Adel, Z, Giladi, M, Ernestus, RI, Löhr, M, Förster, C, and Hagemann, C

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Tumor Treating Fields (TTFields) are alternating electrical fields that are approved and effective for glioblastoma therapy with a frequency of 200 kHz. At a frequency of 100 kHz, we have previously shown that TTFields can transiently open the blood-brain barrier (BBB) in vitro and in vivo [for full text, please go to the a.m. URL]

Published
2022
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16. Assessment of functional outcome after resection of eloquently located lower grade gliomas based on the LoG-Glio registry

Author

Pala, A, Onken, JS, Rückriegel, S, von der Brelie, C, Nadji-Ohl, M, Forster, MT, Gerlach, R, Unteroberdörster, M, Roder, C, Kniese, K, Schommer, S, Rothenbacher, D, Nagel, G, Wirtz, CR, Ernestus, RI, Nabavi, A, Tatagiba, M, Czabanka, M, Ganslandt, O, Rohde, V, Löhr, M, Vajkoczy, P, and Coburger, J

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Lower grade gliomas (LGG) often infiltrate eloquent regions, so that neurological impairment and oncological benefit by surgery have to be balanced. Aim of our study was to assess rate of permanent deficits and its risk factors in eloquently located LGGs. Methods: We retrieved all patients [for full text, please go to the a.m. URL]

Published
2022
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17. Blood lipid spectrum and elastic properties of arteries in patients with chronic pancreatitis in combination with arterial hypertension

Author

Filippova A.Yu., Löhr M., and Kryvoshei V.V.

Subjects
chronic pancreatitis, elastic properties of arteries, arterial hypertension, lipids (amino acids, peptides, and proteins), General Medicine, blood lipid spectrum
Abstract

110 patients aged 45-65 years with chronic pancreatitis were examined. The first group consisted of patients with a combined course of chronic pancreatitis with arterial hypertension; the second group - patients with chronic pancreatitis without concomitant hypertension. All patients were examined for total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol. Arterial stiffness was determined by the pulse wave velocity. It was found that patients of the 1st group had significantly higher levels of triglycerides (37.2%), low-density lipoprotein cholesterol (13%), total cholesterol (25%), atherogenic ratio (19.6%) and significantly lower levels of high-density lipoprotein cholesterol (15.4%). Correlations between age and the level of atherogenic ratio, low-density lipoprotein cholesterol were established – r=0.35; p

Published
2022

18. The find-the-symbol test to detect and monitor deficits of visual attention and executive functions in brain tumour patients

Author

Schröter, C, Wagner, AM, Rodrian, K, Kochs, S, Rehme, AK, Nettekoven, C, Louçäo, R, Wiewrodt, D, Löhr, M, Jungk, C, Goldbrunner, R, Weiß-Lucas, C, NOA-19 Study Group, Schröter, C, Wagner, AM, Rodrian, K, Kochs, S, Rehme, AK, Nettekoven, C, Louçäo, R, Wiewrodt, D, Löhr, M, Jungk, C, Goldbrunner, R, Weiß-Lucas, C, and NOA-19 Study Group

Published
2022

21. Neurocognitive symptom clusters in patients with newly diagnosed glioblastoma

Author

Rodrian, K, Kochs, S, Schröter, C, Rehme, AK, Nettekoven, C, Louçäo, R, Wiewrodt, D, Löhr, M, Jungk, C, Goldbrunner, R, Weiß-Lucas, C, NOA-19 Study Group, Rodrian, K, Kochs, S, Schröter, C, Rehme, AK, Nettekoven, C, Louçäo, R, Wiewrodt, D, Löhr, M, Jungk, C, Goldbrunner, R, Weiß-Lucas, C, and NOA-19 Study Group

Published
2022

23. Resilience in lower grade glioma patients

Author

Coburger, J, Fröhlich, E, Nadji-Ohl, M, Unteroberdörster, M, Rückriegel, S, von der Brelie, C, Roder, C, Forster, MT, Schommer, S, Löhr, M, Pala, A, Goebel, S, Onken, JS, Wirtz, CR, Czabanka, M, Tatagiba, M, Rohde, V, Ernestus, RI, Vajkoczy, P, Ganslandt, O, Renovanz, M, Coburger, J, Fröhlich, E, Nadji-Ohl, M, Unteroberdörster, M, Rückriegel, S, von der Brelie, C, Roder, C, Forster, MT, Schommer, S, Löhr, M, Pala, A, Goebel, S, Onken, JS, Wirtz, CR, Czabanka, M, Tatagiba, M, Rohde, V, Ernestus, RI, Vajkoczy, P, Ganslandt, O, and Renovanz, M

Published
2022

29. The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease

Author

Wallace, Zachary S, Naden, Ray P, Chari, Suresh, Choi, Hyon K, Della-Torre, Emanuel, Dicaire, Jean-Francois, Hart, Phillip A, Inoue, Dai, Kawano, Mitsuhiro, Khosroshahi, Arezou, Lanzillotta, Marco, Okazaki, Kazuichi, Perugino, Cory A, Sharma, Amita, Saeki, Takako, Schleinitz, Nicolas, Takahashi, Naoki, Umehara, Hisanori, Zen, Yoh, Stone, Collaborators: Akamizu T, John H., Akiyama, M, Barra, L, Bateman, A, Blockmans, D, Brito-Zeron, P, Campochiaro, C, Carruthers, M, Chiba, T, Cornell, L, Culver, E, Darabian, S, Deshpande, V, Dong, L, Ebbo, M, Fernández-Codina, A, Ferry, Ja, Fragkoulis, G, Frost, F, Frulloni, Luca, Hernandez-Molina, G, Ji, H, Keat, K, Kamisawa, T, Kawa, S, Kobayashi, H, Kodama, Y, Kubo, S, Kubota, K, Leng, H, Lerch, Mm, Liu, Y, Liu, Z, Löhr, M, Martin-Nares, E, Martinez-Valle, F, Marvisi, C, Masaki, Y, Matsui, S, Mizushima, I, Nakamura, S, Nordeide, J, Notohara, K, Paira, S, Popovic, J, Ramos-Casals, M, Rosenbaum, J, Ryu, J, Sato, Y, Sekiguchi, H, Sokol, Ev, Stone, Jr, Sun, W, Takahashi, H, Takahira, M, Tanaka, Y, Vaglio, A, Villamil, A, Wada, Y, Webster, G, Yamada, K, Yamamoto, M, Yi, J, Yi, Y, Zamboni, G, Zhang, W., Wallace, Z, Naden, Rp, Chari, S, Choi, Hk, DELLA TORRE, E, Dicaire, Jf, Hart, Pa, Inoue, D, Kawano, M, Khosroshahi, A, Lanzillotta, M, Okazaki, K, Perugino, Ca, Sharma, A, Saeki, T, Schleinitz, N, Takahashi, N, Umehara, H, Zen, Y, Stone, Jh, and Members of the ACR/EULAR IgG4-RD Classification Criteria Working, Group.

Subjects
rheumatoid arthritis, Adult, Male, 0301 basic medicine, medicine.medical_specialty, Immunology, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, parasitic diseases, Epidemiology, Humans, Immunology and Allergy, Medicine, Pathological, Sjøgren's syndrome, Aged, 030203 arthritis & rheumatology, business.industry, Middle Aged, inflammation, medicine.disease, Test (assessment), 030104 developmental biology, Rheumatoid arthritis, Radiological weapon, Female, Immunoglobulin G4-Related Disease, business, Rheumatism, Decision analysis
Abstract

IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serological, radiological and pathological data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators used consensus exercises; existing literature; derivation and validation cohorts of 1879 subjects (1086 cases, 793 mimickers); and multicriterion decision analysis to identify, weight and test potential classification criteria. Two independent validation cohorts were included. A three-step classification process was developed. First, it must be demonstrated that a potential IgG4-RD case has involvement of at least one of 11 possible organs in a manner consistent with IgG4-RD. Second, exclusion criteria consisting of a total of 32 clinical, serological, radiological and pathological items must be applied; the presence of any of these criteria eliminates the patient from IgG4-RD classification. Third, eight weighted inclusion criteria domains, addressing clinical findings, serological results, radiological assessments and pathological interpretations, are applied. In the first validation cohort, a threshold of 20 points had a specificity of 99.2% (95% CI 97.2% to 99.8%) and a sensitivity of 85.5% (95% CI 81.9% to 88.5%). In the second, the specificity was 97.8% (95% CI 93.7% to 99.2%) and the sensitivity was 82.0% (95% CI 77.0% to 86.1%). The criteria were shown to have robust test characteristics over a wide range of thresholds. ACR/EULAR classification criteria for IgG4-RD have been developed and validated in a large cohort of patients. These criteria demonstrate excellent test performance and should contribute substantially to future clinical, epidemiological and basic science investigations.

Published
2019

30. Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

Author

van Grinsven, Janneke, van Brunschot, Sandra, Bakker, Olaf J., Bollen, Thomas L., Boermeester, Marja A., Bruno, Marco J., Dejong, Cornelis H., Dijkgraaf, Marcel G., van Eijck, Casper H., Fockens, Paul, van Goor, Harry, Gooszen, Hein G., Horvath, Karen D., van Lienden, Krijn P., van Santvoort, Hjalmar C., Besselink, Marc G., Abdelhafez, M, Andersson, R, Andren-Sandberg, A, Ashley, S, van Baal, M, Baron, T, Bassi, C, Bradley, E, Buchler, M, Cappendijk, V, Carter, R, Charnley, R, Coelho, D, Connor, S, Dellinger, P, Dervenis, C, Deviere, J, Doctor, N, Dudeja, V, En-qiang, M, Escourrou, J, Fagenholz, P, Farkas, G, Forsmark, C, Freeman, M, Freeny, P, French, J, Friess, H, Gardner, T, Goetzinger, P, Haveman, J, Hofker, S, Imrie, C, Isaji, S, Isenmann, R, Klar, E, Laméris, J, Lerch, M, Lévy, P, Lillemoe, K, Löhr, M, Mayerle, J, Mayumi, T, Mittal, A, Moessner, J, Morgan, D, Mortele, K, Nealon, W, Neoptolemos, J, Nieuwenhuijs, V, Nordback, I, Olah, A, Oppong, K, Padbury, R, Papachristou, G, Parks, R, Poley, J, Radenkovic, D, Raraty, M, Rau, B, Rebours, V, Rische, S, Runzi, M, Sainani, N, Sarr, M, Schaapherder, S, Seewald, S, Seifert, H, Shimosegawa, T, Silverman, S, Singh, V, Siriwardena, A, Steinberg, W, Sutton, R, Takeda, K, Timmer, R, Vege, S, Voermans, R, de Waele, J, Wang, Ch, Warshaw, A, Werner, J, Weusten, B, Whitcomb, D, Wig, J, Windsor, J, and Zyromski, N

Published
2015
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34. Characterisation of heterogeneous antigen-expression pattern comparing glioblastoma cell lines, patient-derived cells and patients’ glioblastoma tissue

Author

Dufner, V, Schulz, E, Monoranu, C, Hudecek, M, Hagemann, C, Ernestus, RI, Löhr, M, and Nerreter, T

Subjects
ddc: 610, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Objective: Immunotherapeutic treatment of glioblastoma (GBM) is one of the most challenging tasks due to heterogeneous surface expression of target antigens. It has previously been reported that GBM cell lines (GCL), patient-derived cells (PDC) and patients’ tumour tissue (PT) differ strongly[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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36. International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease

Author

Khosroshahi, A., Wallace, Z. S., Crowe, J. L., Akamizu, T., Azumi, A., Carruthers, M. N., Chari, S. T., Della-Torre, E., Frulloni, L., Goto, H., Hart, P. A., Kamisawa, T., Kawa, S., Kawano, M., Kim, M. H., Kodama, Y., Kubota, K., Lerch, M. M., Löhr, M., Masaki, Y., Matsui, S., Mimori, T., Nakamura, S., Nakazawa, T., Ohara, H., Okazaki, K., Ryu, J. H., Saeki, T., Schleinitz, N., Shimatsu, A., Shimosegawa, T., Takahashi, H., Takahira, M., Tanaka, A., Topazian, M., Umehara, H., Webster, G. J., Witzig, T. E., Yamamoto, M., Zhang, W., Chiba, T., and Stone, J. H.

Published
2015
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40. Diagnosis and treatment of pancreatic duct disruption or disconnection: an international expert survey and case vignette study

Author

Boxhoorn, Lotte, primary, Timmerhuis, Hester C., additional, Verdonk, Robert C., additional, Besselink, Marc G., additional, Bollen, Thomas L., additional, Bruno, Marco J., additional, Elmunzer, B. Joseph, additional, Fockens, Paul, additional, Horvath, Karen D., additional, van Santvoort, Hjalmar C., additional, Voermans, Rogier P., additional, Albert, J., additional, Arvanitakis, M., additional, Badaoui, A., additional, Barthet, M., additional, van Biervliet, G., additional, Bradley, E., additional, Boermeester, M., additional, Buchler, M., additional, Cappendijk, V., additional, Charnley, R., additional, Connor, S., additional, Dejong, C., additional, Dellinger, P., additional, Dervenis, C., additional, Deviere, J., additional, Dumonceau, J., additional, van Eijck, C., additional, Fagenholz, P., additional, Castillo, C.Fernandez-del, additional, Forsmark, C., additional, Freeman, M., additional, French, J., additional, van Goor, H., additional, Haveman, J.W., additional, van Hooft, J., additional, Hucl, T., additional, Isaji, S., additional, Jagielski, M., additional, Karjula, H., additional, Lerch, M., additional, Lévy, P., additional, Lillemoe, K., additional, Löhr, M., additional, Mayerle, J., additional, Mittal, A., additional, Morgan, D., additional, Moon, S., additional, Nieuwenhuijs, V., additional, Sarr, M., additional, Seewald, S., additional, Sherman, S., additional, Singh, V., additional, Siriwardena, A., additional, Stommel, M., additional, Tann, M., additional, Téllez-Avina, F., additional, Timmer, R., additional, Traverso, W., additional, Radenkovic, D., additional, Rana, S., additional, Rebours, V., additional, Pelaez-Luna, M., additional, Poley, J.W., additional, Windsor, J., additional, Zaheer, A., additional, and Zyromski, N., additional

Published
2021
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43. Risk of developing pancreatic cancer in patients with chronic pancreatitis

Author

Vujasinovic, M., primary, Dugic, A., additional, Maisonneuve, P., additional, Aljic, A., additional, Berggren, R., additional, Panic, N., additional, Valente, R., additional, Mucelli, R. Pozzi, additional, Waldthaler, A., additional, Ghorbani, P., additional, Kordes, M., additional, Hagström, H., additional, and Löhr, M., additional

Published
2021
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44. Leukocyte-DNA methylome explains a large proportion of the risk variability of pancreatic cancer

Author

López De Maturana, E., primary, Alonso, L., additional, Carrato, A., additional, Iglesias, M., additional, Molero, X., additional, Hidalgo, M., additional, Perea, J., additional, Barberá, V., additional, Farré, A., additional, Tardón, A., additional, Dominguez-Muñoz, E., additional, Muñoz-Bellvís, L., additional, Crnogorac-Jurcevic, T., additional, Greenhalf, W., additional, Gress, T., additional, Löhr, M., additional, Lawlor, R.T., additional, Michalski, C., additional, Rorke, M.O., additional, Sharp, L., additional, Real, F.X., additional, and Malats, N., additional

Published
2021
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46. Diagnosis and treatment of pancreatic duct disruption or disconnection: an international expert survey and case vignette study

Author

Boxhoorn, L. (Lotte), Timmerhuis, H.C. (Hester C.), Verdonk, R.C. (Robert), Besselink, M.G. (Marc), Bollen, T.L. (Thomas), Bruno, M.J. (Marco J.), Elmunzer, B.J. (B. Joseph), Fockens, P. (Paul), Horvath, K.D. (Karen D.), Santvoort, H.C. (Hjalmar) van, Voermans, R.P. (Rogier), Albert, J. (J.), Arvanitakis, M. (M.), Badaoui, A. (A.), Barthet, M. (M.), van Biervliet, G. (G.), Bradley, E. (E.), Boermeester, M.A. (Marja), Buchler, M.W. (M.), Cappendijk, V.C., Charnley, R. (R.), Connor, S. (S.), Dejong, C. (C.), Dellinger, P. (P.), Dervenis, C. (Christos), Deviere, J. (J.), Dumonceau, J.M., Eijck, C.H.J. (Casper) van, Fagenholz, P. (P.), Castillo, C.F.-D. (C.Fernandez-del), Forsmark, C. (C.), Freeman, M. (M.), French, J. (J.), Goor, H. (Harry) van, Haveman, J.W., Hooft, J.E. (Jeanin) van, Hucl, T. (Tomas), Isaji, S. (S.), Jagielski, M. (M.), Karjula, H. (H.), Lerch, M. (M.), Lévy, P. (Philippe), Lillemoe, K. (K.), Löhr, M. (M.), Mayerle, J. (Julia), Mittal, A. (A.), Morgan, D. (D.), Moon, S. (S.), Nieuwenhuijs, V.B. (Vincent), Sarr, M. (M.), Seewald, S. (Stefan), Sherman, S. (S.), Singh, V. (V.), Siriwardena, A. (A.), Stommel, M. (M.), Tann, M. (M.), Téllez-Avina, F. (F.), Timmer, R. (Robin), Traverso, W. (W.), Radenkovic, D. (D.), Rana, S. (S.), Rebours, V. (Vinciane), Pelaez-Luna, M. (M.), Poley, J.-W. (Jan-Werner), Windsor, J. (J.), Zaheer, A. (A.), Zyromski, N. (N.), Boxhoorn, L. (Lotte), Timmerhuis, H.C. (Hester C.), Verdonk, R.C. (Robert), Besselink, M.G. (Marc), Bollen, T.L. (Thomas), Bruno, M.J. (Marco J.), Elmunzer, B.J. (B. Joseph), Fockens, P. (Paul), Horvath, K.D. (Karen D.), Santvoort, H.C. (Hjalmar) van, Voermans, R.P. (Rogier), Albert, J. (J.), Arvanitakis, M. (M.), Badaoui, A. (A.), Barthet, M. (M.), van Biervliet, G. (G.), Bradley, E. (E.), Boermeester, M.A. (Marja), Buchler, M.W. (M.), Cappendijk, V.C., Charnley, R. (R.), Connor, S. (S.), Dejong, C. (C.), Dellinger, P. (P.), Dervenis, C. (Christos), Deviere, J. (J.), Dumonceau, J.M., Eijck, C.H.J. (Casper) van, Fagenholz, P. (P.), Castillo, C.F.-D. (C.Fernandez-del), Forsmark, C. (C.), Freeman, M. (M.), French, J. (J.), Goor, H. (Harry) van, Haveman, J.W., Hooft, J.E. (Jeanin) van, Hucl, T. (Tomas), Isaji, S. (S.), Jagielski, M. (M.), Karjula, H. (H.), Lerch, M. (M.), Lévy, P. (Philippe), Lillemoe, K. (K.), Löhr, M. (M.), Mayerle, J. (Julia), Mittal, A. (A.), Morgan, D. (D.), Moon, S. (S.), Nieuwenhuijs, V.B. (Vincent), Sarr, M. (M.), Seewald, S. (Stefan), Sherman, S. (S.), Singh, V. (V.), Siriwardena, A. (A.), Stommel, M. (M.), Tann, M. (M.), Téllez-Avina, F. (F.), Timmer, R. (Robin), Traverso, W. (W.), Radenkovic, D. (D.), Rana, S. (S.), Rebours, V. (Vinciane), Pelaez-Luna, M. (M.), Poley, J.-W. (Jan-Werner), Windsor, J. (J.), Zaheer, A. (A.), and Zyromski, N. (N.)

Abstract

Background: Pancreatic duct disruption or disconnection is a potentially severe complication of necrotizing pancreatitis. With no existing treatment guidelines, it is unclear whether there is any consensus among experts in clinical practice. We evaluated current expert opinion regarding the diagnosis and treatment of pancreatic duct disruption and disconnection in an international case vignette study. Methods: An online case vignette survey was sent to 110 international expert pancreatologists. Expert selection was based on publications in the last 5 years and/or participation in development of IAP/APA and ESGE guidelines on acute pancreatitis. Consensus was defined as agreement by at least 75% of the experts. Results: The response rate was 51% (n = 56). Forty-four experts (79%) obtained a MRI/MRCP and 52 experts (93%) measured amylase levels in percutaneous drain fluid to evaluate pancreatic duct integrity. The majority of experts favored endoscopic transluminal drainage for infected (peri)pancreatic necrosis and pancreatic duct disruption (84%, n = 45) or disconnection (88%, n = 43). Consensus was lacking regarding the treatment of patients with persistent percutaneous drain production, and with persistent sterile necrosis. Conclusion: This international survey of experts demonstrates that there are many areas for which no consensus existed, providing clear focus for future investigation.

Published
2021
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