Search

Your search keyword '"Löbenberg, Raimar"' showing total 626 results
Start Over Author "Löbenberg, Raimar"
626 results on '"Löbenberg, Raimar"'

7. Unveiling microtubule dynamics in lung cancer: Recent findings and prospects for drug delivery and treatment

Author

Yukuyama, Megumi Nishitani, de Souza, Aline, Henostroza, Mirla Anali Bazán, de Araujo, Gabriel Lima Barros, Löbenberg, Raimar, Faria, Rafael de Oliveira, de Souza, Gabriel Batista, Guimaraes, Lara Mendes Ferreira, Lameu, Claudiana, Folchini, Beatriz Rabelo, Peroni, Camilla Midori, Oliveira, Isabela Fernandes, Miyagi, Mariana Yasue Saito, and Bou-Chacra, Nádia Araci

Published
2023
Full Text
View/download PDF

9. Effects of self-assembled cell-penetrating peptides and their nano-complexes on ABCB1 expression and activity

Author

Niazi, Mehri, Zakeri-Milani, Parvin, Soleymani-Goloujeh, Mehdi, Mohammadi, Ali, Sarfraz, Muhammad, Löbenberg, Raimar, Najafi-Hajivar, Saeedeh, Shahbazi-Mojarrad, Javid, Farshbaf, Masoud, and Valizadeh, Hadi

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Cancer, Cancer therapy, CPPs, Doxorubicin, Multi-drug resistance, P-gp
Abstract

ObjectivesDoxorubicin (Dox) is one of the most well-known chemotherapeutics that are commonly applied for a wide range of cancer treatments. However, in most cases, efflux pumps like P-glycoprotein (P-gp), expel the taken drugs out of the cell and decrease the Dox bioavailability. Expression of P-gp is associated with elevated mRNA expression of the ATP-binding cassette B1 (ABCB1) gene.Materials and methodsIn the current study, different sequences of cell-penetrating peptides (CPPs) containing tryptophan, lysine, and arginine and their nano-complexes were synthesized and their impact on the expression and activity of the ABCB1 gene was evaluated in the A549 lung carcinoma cell line. Furthermore, the cellular uptake of designed CPPs in the A549 cell line was assessed.ResultsThe designed peptides, including [W4K4], [WR]3-QGR, R10, and K10 increased Dox cytotoxicity after 48 hr. Furthermore, arginine-rich peptides showed higher cellular uptake. Rhodamin123 accumulation studies illustrated that all the obtained peptides could successfully inhibit the P-gp pump. The designed peptides inhibited the ABCB1 gene expression, of which, [W4K4] resulted in the lowest expression ratio.Conclusion[W4K4], [WR]3-QGR, R10, and K10 could successfully increase the Dox cytotoxicity by decreasing the efflux pump gene expression.

Published
2021

11. Chitosan modified 5-fluorouracil nanostructured lipid carriers for treatment of diabetic retinopathy in rats: A new dimension to an anticancer drug

Author

Sharma, Deep Shikha, Wadhwa, Sheetu, Gulati, Monica, Kumar, Bimlesh, Chitranshi, Nitin, Gupta, Vivek Kumar, Alrouji, Mohammed, Alhajlah, Sharif, AlOmeir, Othman, Vishwas, Sukriti, Khursheed, Rubiya, Saini, Sumant, Kumar, Ankit, Parveen, Shaik Rahana, Gupta, Gaurav, Zacconi, Flavia, Chellappan, Dinesh Kumar, Morris, Andrew, Loebenberg, Raimar, Dua, Kamal, and Singh, Sachin Kumar

Published
2023
Full Text
View/download PDF

13. Malignant wound – The influence of oil components in flubendazole-loaded nanoemulsions in A549 lung cancer xenograft-bearing mice

Author

Yukuyama, Megumi Nishitani, Guimaraes, Lara Mendes Ferreira, Segovia, Rafael Scheliga, Lameu, Claudiana, de Araujo, Gabriel Lima Barros, Löbenberg, Raimar, de Souza, Aline, Henostroza, Mirla Anali Bazán, Folchini, Beatriz Rabelo, Peroni, Camilla Midori, Miyagi, Mariana Yasue Saito, Oliveira, Isabela Fernandes, Alvarenga, José Fernando Rinaldi, Fiamoncini, Jarlei, and Bou-Chacra, Nádia Araci

Published
2022
Full Text
View/download PDF

16. Upholding or Breaking the Law of Superposition in Pharmacokinetics.

Author

Yousef, Malaz, Yáñez, Jaime A., Löbenberg, Raimar, and Davies, Neal M.

Subjects
ORAL drug administration, POISONS, SUPERPOSITION principle (Physics), INTRAVENOUS therapy, DRUG development
Abstract

The law of superposition underpins first-order linear pharmacokinetic relationships. Most drugs, therefore, after a single dose can be described by first-order or linear processes, which can be superposed to understand multiple-dose regimen behavior. However, there are a number of situations where drugs could display behaviors after multiple dosing that leads to capacity-limited or saturation non-linear kinetics and the law of superposition is overruled. This review presents a practical guide to understand the equations and calculations for single and multiple-dosing regimens after intravenous and oral administration. It also provides the pharmaceutical basis for saturation in ADME processes and the consequent changes in the area under the concentration–time curve, which represents drug exposure that can lead to the modulation of efficacy and/or toxic effects. The pharmacokineticist must implicitly understand the principles of superposition, which are a central tenet of drug behavior and disposition during drug development. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

33. Hydroxymethylnitrofurazone lymphatic uptake with nanostructured lipid carrier after oral administration in rats.

Author

Souza, Aline de, Scarim, Cauê Benito, Cotrim, Paulo Cesar, Junior, Fernando Barbosa, Rocha, Bruno Alves, Calixto, Leandro Augusto, Correia, Cristiano Jesus, de Barros Araújo, Gabriel Lima, Löbenberg, Raimar, Bou-Chacra, Nádia Araci, and Breithaupt-Faloppa, Ana Cristina

Abstract

Background: Leishmaniasis, caused by the protozoan Leishmania sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking flow model in rats. Method: Lymphatic uptake of NFOH was assessed 1 h after oral administration of dimethyl sulfoxide with NFOH or NLC-NFOH with and without cycloheximide pretreatment. Result: Dimethyl sulfoxide with NFOH and NLC-NFOH showed NFOH serum concentrations of 0.0316 and 0.0291 μg/ml, respectively. After chylomicron blocking, NFOH was not detected. Conclusion: Despite log P below 5, NFOH was successfully taken up by the lymphatic system. Long-chain fatty acids and particle size might be main factors in these findings. NLC-NFOH is a promising and convenient platform for treating leishmaniasis via oral administration. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

36. Corrigendum to - Chitosan modified 5-fluorouracil nanostructured lipid carriers for treatment of diabetic retinopathy in rats: A new dimension to an anticancer drug, Vol. 224, 1 January 2023, Pages 810-830

Author

Sharma, Deep Shikha, Wadhwa, Sheetu, Gulati, Monica, Kumar, Bimlesh, Chitranshi, Nitin, Gupta, Vivek Kumar, Alrouji, Mohammed, Alhajlah, Sharif, AlOmeir, Othman, Vishwas, Sukriti, Khursheed, Rubiya, Saini, Sumant, Kumar, Ankit, Parveen, Shaik Rahana, Gupta, Gaurav, Zacconi, Flavia, Chellappan, Dinesh Kumar, Morris, Andrew, Loebenberg, Raimar, Dua, Kamal, and Singh, Sachin Kumar

Published
2024
Full Text
View/download PDF

38. Investigation of Cannabinoid Acid/Cyclodextrin Inclusion Complex for Improving Physicochemical and Biological Performance.

Author

Park, Chulhun, Zuo, Jieyu, Gil, Myung-Chul, Löbenberg, Raimar, and Lee, Beom-Jin

Subjects
INCLUSION compounds, CYCLODEXTRINS, X-ray emission spectroscopy, CANNABINOIDS, NUCLEAR magnetic resonance spectroscopy, DIFFERENTIAL scanning calorimetry, SCANNING electron microscopy, X-ray diffraction
Abstract

This study aimed to investigate the enhancement of cannabinoid acid solubility and stability through the formation of a cannabinoid acid/cyclodextrin (CD) inclusion complex. Two cannabinoid acids, tetrahydro-cannabinolic acid (THCA) and cannabidiolic acid (CBDA), were selected as a model drug along with five types of CD: α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), and methylated-β-cyclodextrin (M-β-CD). Phase solubility studies were conducted using various types of CD to determine the complex stoichiometry. The preparation methods of the CD inclusion complex were optimized by adjusting the loading pH solution and the drying processes (spray-drying, freeze-drying, spray-freeze-drying). The drying process of the cannabinoid acid/M-β-CD inclusion complex was further optimized through the spray-freeze-drying method. These CD complexes were characterized using solubility determination, differential scanning calorimetry (DSC), field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and 1H NMR spectroscopy. DSC, XRD, and FE-SEM studies confirmed the non-crystalline state of the cannabinoid acid/CD inclusion complex. The permeation of THCA or CBDA from the M-β-CD spray-freeze-dried inclusion complex was highly improved compared to those of cannabis ethanolic extracts under simulated physiological conditions. The stability of the cannabinoid acid/M-β-CD inclusion complex was maintained for 7 days in a simulated physiological condition. Furthermore, the minimum inhibitory concentration of cannabinoid acid/M-β-CD inclusion complex had superior anti-cancer activity in MCF-7 breast cancer cell lines compared to cannabinoid acid alone. The improved physicochemical and biological performances indicated that these CD inclusion complexes could provide a promising option for loading lipophilic cannabinoids in cannabis-derived drug products. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

44. Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa.

Author

O'Croinin, Conor, Garcia Guerra, Andres, Doschak, Michael R., Löbenberg, Raimar, and Davies, Neal M.

Subjects
CANNABIS (Genus), STILBENE, PREDICTION models, PHYTOTHERAPY, STILBENE derivatives, PLANT metabolites, METABOLITES
Abstract

Cannabis sativa is a plant used for recreational and therapeutic purposes; however, many of the secondary metabolites in the plant have not been thoroughly investigated. Stilbenes are a class of compounds with demonstrated anti-inflammatory and antioxidant properties and are present in cannabis. Many stilbenes present in cannabis have been investigated for their therapeutic effects. Fourteen stilbenes have been identified to be present in cannabis, all of which are structurally dihydrostilbenoids, with half possessing a prenylated moiety. The stilbenes summarized in this analysis show varying degrees of therapeutic benefits ranging from anti-inflammatory, antiviral, and anti-cancer to antioxidant effects. Many of the identified stilbenes have been researched to a limited extent for potential health benefits. In addition, predictive in silico modeling was performed on the fourteen identified cannabis-derived stilbenes. This modeling provides prospective activity, pharmacokinetic, metabolism, and permeability data, setting the groundwork for further investigation into these poorly characterized compounds. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results