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5. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

Author

Abe, Tomoyuki, Abu Hilal, Moh'd, Achalandabaso Boira, Maria del Mar, Adham, Mustapha, Adam, Mohamed, Ahmad, Maryam, Al-Sarireh, Bilal, Albiol, Maite, Alhaboob, Nassir, Alseidi, Adnan, Ammar, Houssem, Anand, Akshay, Andersson, Bodil, Antonakis, Pantelis, Araya, Veronica, Ashley, Stanley W., Atanasov, Georgi, Ausania, Fabio, Balestri, Ricardo, Banerjee, Abhirup, Banerjee, Sudeep, Banting, Simon, Barauskas, Giedrius, Bartsch, Fabian, Belli, Andrea, Beretta, Simona, Berrevoet, Frederik, Bhandari, Ramesh Singh, Blanco Fernandez, Gerardo, Bolm, Louisa, Bonal, Mathieu, Bozkurt, Emre, Braat, Andries E., Bradshaw, Luke, Bramis, Konstantinos, Branes, Alejandro, Burdine, Lyle, Byrne, Matthew, Caceres, Maria, Castro Santiago, Maria Jesus, Chan, Benjamin, Chong, Lynn, Çoker, Ahmet, Conde Rodriguez, Maria, Croagh, Daniel, Crutchley, Alyn, Cutolo, Carmen, D'Hondt, Mathieu, D'Souza, Daniel, Daams, Freek, Dalla Valle, Raffaele, Davide, José, de Bellis, Mario, de Boer, Marieke, de Meyere, Celine, de Reuver, Philip, Dixon, Matthew, Dorovinis, Panagiotis, Echeverría Bauer, Gabriela, Eduarda, Maria, Eker, Hasan, Erdmann, Joris, Erkan, Mert, Felekouras, Evangelos, Felli, Emanuele, Fernandes, Eduardo, Figueroa Rivera, Eduardo, Fulop, Andras, Galun, Daniel, Gerhards, Michael, Ghorbani, Poya, Giannone, Fabio, Gil, Luis, Giorgakis, Emmanouil, Giuffrida, Mario, Giuliante, Felice, Gkekas, Ioannis, Gomez Bravo, Miguel, Groot Koerkamp, Bas, Guevara, Oscar, Guglielmi, Alfredo, Gulla, Aiste, Gupta, Rahul, Gupta, Amit, Gutiérrez, Marta, Hafeez Bhatti, Abu Bakar, Hagendoorn, Jeroen, Hajee, Zain, Hakeem, Abdul Rahman, Hamid, Hytham, Hassen, Sayed, Heinrich, Stefan, Higuchi, Ryota, Hoffman, Daniel, Holroyd, David, Hughes, Daniel, Ivanecz, Arpad, Iype, Satheesh, Jaen Torrejimeno, Isabel, Joglekar, Shantanu, Jones, Robert, Kaczirek, Klaus, Kanhere, Harsh, Kausar, Ambareen, Kee, Zhanyi, Keilson, Jessica, Kleef, Jorg, Klose, Johannes, Knowles, Brett, Koong, Jun Kit, Kumar, Nagappan, Kunnuru, Supreeth, Lakhey, Paleswan Joshi, Laurenzi, Andrea, Lee, Yeong Sing, Leon, Felipe, Leow, Voon Meng, Lequeu, Jean-Baptiste, Lesurtel, Mickael, Lo, Elisabeth, Löb, Stefan, Lockie, Elizabeth, Lodge, Peter, López Garnica, Dolores, Lopez Lopez, Victor, Lundgren, Linda, Machairas, Nikolaos, Maharjan, Dhiresh, Malde, Deep, Martel, Guillaume, Martin, Julie, Mazzola, Michele, Mehrabi, Arianeb, Memeo, Ricardo, Milana, Flavio, Molina, George, Monette, Leah, Morgul, Haluk, Moris, Dimitrios, Morsi-Yeroyannis, Antonios, Mowbray, Nicholas, Mulita, Francesk, Muttillo, Edoardo Maria, Nandasena, Malith, Nashidengo, Pueya Rashid, Nickkholgh, Arash, Noel, Colin Byron, Ohtsuka, Masayuki, Ozolins, Arturs, Pandanaboyana, Sanjay, Pararas, Nikolaos, Parente, Alessandro, Peng, June, Perfecto Valero, Arkaitz, Perinel, Julie, Perivoliotis, Konstatinos, Perra, Teresa, Pessaux, Patrick, Petruch, Natalie, Piccolo, Gaetano, Piros, Laszlo, Porcu, Alberto, Prabakaran, Viswakumar, Prasad, Raj, Prieto Calvo, Mikel, Primavesi, Florian, Pueyo Periz, Eva Maria, Quaglia, Alberto, Ramia Angel, Jose M., Rammohan, Ashwin, Razionale, Francesco, Robles Campos, Ricardo, Roy, Manas, Rozwadowski, Sophie, Ruffolo, Luis, Ruiz, Natalia, Ruzzenante, Andrea, Saadat, Lily, Said, Mohamed Amine, Saladino, Edoardo, Saliba, Gabriel, Sandstrom, Per, Schena, Carlo Alberto, Scholer, Anthony, Schwarz, Christoph, Serafini, Lorenzo, Serrano, Pablo E., Sharma, Deepak, Sheen, Aali, Siddagangaiah, Vishwanath, Silva, Michael, Singh, Saurabh, Siriwardena, Ajith, Skalski, Michal, Smig, Mante, Soliman, Faris, Sonkar, Abhinav Arun, Sousa Silva, Donzília, Sparrelid, Ernesto, Srinivasan, Parthi, Sternby Eilard, Malin, Strobel, Oliver, Stupan, Urban, Suarez-Munoz, Miguel Angel, Subramaniam, Manisekar, Sugiura, Teiichi, Sutcliffe, Robert, Swank, Hilko, Taylor, Lillian, Thapa, Prabin Bikram, The, Catherine, Thepbunchonchai, Asara, Thieu, Caman, Tiwari, Navneet, Torzilli, Guido, Tovikkai, Chutwichai, Trotovsek, Blaz, Tsaramanidis, Savvas, Tsoulfas, Georgios, Uesaka, Katsuhiko, Umar, Garzali, Urbani, Lucio, Vailas, Michail, van Dam, Ronald, van de Boezem, Peter, van Laarhoven, Stijn, Vanagas, Tomas, Van Dooren, Mike, Viennet, Manon, Vigano, Luca, Vijayashanker, Aarathi, Villodre, Celia, Wakai, Toshifumi, Workneh, Aklile, Xu, Li, Yamamoto, Masakazu, Yang, Zhiying, Young, Robert, Zivanovic, Marko, Balakrishnan, Anita, Barmpounakis, Petros, Demiris, Nikolaos, Jah, Asif, Spiers, Harry V.M., Talukder, Shibojit, Martin, Jack L., Gibbs, Paul, Harper, Simon J.F., Huguet, Emmanuel L., Kosmoliaptsis, Vasilis, Liau, Siong S., Praseedom, Raaj K., Basu, Bristi, de Aretxabala, Xavier, Lendoire, Javier, Maithel, Shishir, Serrablo, Alejandro, and Adsay, Volkan

Published
2023
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11. Perioperative management of anticoagulant therapy

Author

Wagner Johanna, Lock Johan F., Kastner Carolin, Klein Ingo, Krajinovic Katica, Löb Stefan, Germer Christoph-Thomas, and Wiegering Armin

Subjects
anticoagulation, bridging, dalteparin, enoxaparin, noac, perioperative period, warfarin, Surgery, RD1-811
Abstract

About 10% of patients taking a chronic, oral anticoagulant therapy require an invasive procedure that can be associated with an increased risk for peri-interventional or perioperative bleeding. Depending on the risk for thromboembolism and the risk for bleeding, the physician has to decide whether the anticoagulant therapy should be interrupted or continued. Patient characteristics such as age, renal function and drug interactions must be considered. The perioperative handling of the oral anticoagulant therapy differs according to the periprocedural bleeding risk. Patients requiring a procedure with a minor risk for bleeding do not need to pause their anticoagulant therapy. For procedures with an increased risk for perioperative bleeding, the anticoagulant therapy should be adequately paused. For patients on a coumarin derivative with a high risk for a thromboembolic event, a perioperative bridging therapy with a low molecular weight heparin is recommended. Due to an increased risk for perioperative bleeding in patients on a bridging therapy, it is not recommended in patients with a low risk for thromboembolism. For patients taking a non-vitamin K oral anticoagulant, a bridging therapy is not recommended due to the fast onset and offset of the medication.

Published
2019
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16. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

Author

Balakrishnan, Anita, primary, Barmpounakis, Petros, additional, Demiris, Nikolaos, additional, Jah, Asif, additional, Spiers, Harry V.M., additional, Talukder, Shibojit, additional, Martin, Jack L., additional, Gibbs, Paul, additional, Harper, Simon J.F., additional, Huguet, Emmanuel L., additional, Kosmoliaptsis, Vasilis, additional, Liau, Siong S., additional, Praseedom, Raaj K., additional, Basu, Bristi, additional, de Aretxabala, Xavier, additional, Lendoire, Javier, additional, Maithel, Shishir, additional, Branes, Alejandro, additional, Andersson, Bodil, additional, Serrablo, Alejandro, additional, Adsay, Volkan, additional, Abe, Tomoyuki, additional, Abu Hilal, Moh'd, additional, Achalandabaso Boira, Maria del Mar, additional, Adham, Mustapha, additional, Adam, Mohamed, additional, Ahmad, Maryam, additional, Al-Sarireh, Bilal, additional, Albiol, Maite, additional, Alhaboob, Nassir, additional, Alseidi, Adnan, additional, Ammar, Houssem, additional, Anand, Akshay, additional, Antonakis, Pantelis, additional, Araya, Veronica, additional, Ashley, Stanley W., additional, Atanasov, Georgi, additional, Ausania, Fabio, additional, Balestri, Ricardo, additional, Banerjee, Abhirup, additional, Banerjee, Sudeep, additional, Banting, Simon, additional, Barauskas, Giedrius, additional, Bartsch, Fabian, additional, Belli, Andrea, additional, Beretta, Simona, additional, Berrevoet, Frederik, additional, Bhandari, Ramesh Singh, additional, Blanco Fernandez, Gerardo, additional, Bolm, Louisa, additional, Bonal, Mathieu, additional, Bozkurt, Emre, additional, Braat, Andries E., additional, Bradshaw, Luke, additional, Bramis, Konstantinos, additional, Burdine, Lyle, additional, Byrne, Matthew, additional, Caceres, Maria, additional, Castro Santiago, Maria Jesus, additional, Chan, Benjamin, additional, Chong, Lynn, additional, Çoker, Ahmet, additional, Conde Rodriguez, Maria, additional, Croagh, Daniel, additional, Crutchley, Alyn, additional, Cutolo, Carmen, additional, D'Hondt, Mathieu, additional, D'Souza, Daniel, additional, Daams, Freek, additional, Dalla Valle, Raffaele, additional, Davide, José, additional, de Bellis, Mario, additional, de Boer, Marieke, additional, de Meyere, Celine, additional, de Reuver, Philip, additional, Dixon, Matthew, additional, Dorovinis, Panagiotis, additional, Echeverría Bauer, Gabriela, additional, Eduarda, Maria, additional, Eker, Hasan, additional, Erdmann, Joris, additional, Erkan, Mert, additional, Felekouras, Evangelos, additional, Felli, Emanuele, additional, Fernandes, Eduardo, additional, Figueroa Rivera, Eduardo, additional, Fulop, Andras, additional, Galun, Daniel, additional, Gerhards, Michael, additional, Ghorbani, Poya, additional, Giannone, Fabio, additional, Gil, Luis, additional, Giorgakis, Emmanouil, additional, Giuffrida, Mario, additional, Giuliante, Felice, additional, Gkekas, Ioannis, additional, Gomez Bravo, Miguel, additional, Groot Koerkamp, Bas, additional, Guevara, Oscar, additional, Guglielmi, Alfredo, additional, Gulla, Aiste, additional, Gupta, Rahul, additional, Gupta, Amit, additional, Gutiérrez, Marta, additional, Hafeez Bhatti, Abu Bakar, additional, Hagendoorn, Jeroen, additional, Hajee, Zain, additional, Hakeem, Abdul Rahman, additional, Hamid, Hytham, additional, Hassen, Sayed, additional, Heinrich, Stefan, additional, Higuchi, Ryota, additional, Hoffman, Daniel, additional, Holroyd, David, additional, Hughes, Daniel, additional, Ivanecz, Arpad, additional, Iype, Satheesh, additional, Jaen Torrejimeno, Isabel, additional, Joglekar, Shantanu, additional, Jones, Robert, additional, Kaczirek, Klaus, additional, Kanhere, Harsh, additional, Kausar, Ambareen, additional, Kee, Zhanyi, additional, Keilson, Jessica, additional, Kleef, Jorg, additional, Klose, Johannes, additional, Knowles, Brett, additional, Koong, Jun Kit, additional, Kumar, Nagappan, additional, Kunnuru, Supreeth, additional, Lakhey, Paleswan Joshi, additional, Laurenzi, Andrea, additional, Lee, Yeong Sing, additional, Leon, Felipe, additional, Leow, Voon Meng, additional, Lequeu, Jean-Baptiste, additional, Lesurtel, Mickael, additional, Lo, Elisabeth, additional, Löb, Stefan, additional, Lockie, Elizabeth, additional, Lodge, Peter, additional, López Garnica, Dolores, additional, Lopez Lopez, Victor, additional, Lundgren, Linda, additional, Machairas, Nikolaos, additional, Maharjan, Dhiresh, additional, Malde, Deep, additional, Martel, Guillaume, additional, Martin, Julie, additional, Mazzola, Michele, additional, Mehrabi, Arianeb, additional, Memeo, Ricardo, additional, Milana, Flavio, additional, Molina, George, additional, Monette, Leah, additional, Morgul, Haluk, additional, Moris, Dimitrios, additional, Morsi-Yeroyannis, Antonios, additional, Mowbray, Nicholas, additional, Mulita, Francesk, additional, Muttillo, Edoardo Maria, additional, Nandasena, Malith, additional, Nashidengo, Pueya Rashid, additional, Nickkholgh, Arash, additional, Noel, Colin Byron, additional, Ohtsuka, Masayuki, additional, Ozolins, Arturs, additional, Pandanaboyana, Sanjay, additional, Pararas, Nikolaos, additional, Parente, Alessandro, additional, Peng, June, additional, Perfecto Valero, Arkaitz, additional, Perinel, Julie, additional, Perivoliotis, Konstatinos, additional, Perra, Teresa, additional, Pessaux, Patrick, additional, Petruch, Natalie, additional, Piccolo, Gaetano, additional, Piros, Laszlo, additional, Porcu, Alberto, additional, Prabakaran, Viswakumar, additional, Prasad, Raj, additional, Prieto Calvo, Mikel, additional, Primavesi, Florian, additional, Pueyo Periz, Eva Maria, additional, Quaglia, Alberto, additional, Ramia Angel, Jose M., additional, Rammohan, Ashwin, additional, Razionale, Francesco, additional, Robles Campos, Ricardo, additional, Roy, Manas, additional, Rozwadowski, Sophie, additional, Ruffolo, Luis, additional, Ruiz, Natalia, additional, Ruzzenante, Andrea, additional, Saadat, Lily, additional, Said, Mohamed Amine, additional, Saladino, Edoardo, additional, Saliba, Gabriel, additional, Sandstrom, Per, additional, Schena, Carlo Alberto, additional, Scholer, Anthony, additional, Schwarz, Christoph, additional, Serafini, Lorenzo, additional, Serrano, Pablo E., additional, Sharma, Deepak, additional, Sheen, Aali, additional, Siddagangaiah, Vishwanath, additional, Silva, Michael, additional, Singh, Saurabh, additional, Siriwardena, Ajith, additional, Skalski, Michal, additional, Smig, Mante, additional, Soliman, Faris, additional, Sonkar, Abhinav Arun, additional, Sousa Silva, Donzília, additional, Sparrelid, Ernesto, additional, Srinivasan, Parthi, additional, Sternby Eilard, Malin, additional, Strobel, Oliver, additional, Stupan, Urban, additional, Suarez-Munoz, Miguel Angel, additional, Subramaniam, Manisekar, additional, Sugiura, Teiichi, additional, Sutcliffe, Robert, additional, Swank, Hilko, additional, Taylor, Lillian, additional, Thapa, Prabin Bikram, additional, The, Catherine, additional, Thepbunchonchai, Asara, additional, Thieu, Caman, additional, Tiwari, Navneet, additional, Torzilli, Guido, additional, Tovikkai, Chutwichai, additional, Trotovsek, Blaz, additional, Tsaramanidis, Savvas, additional, Tsoulfas, Georgios, additional, Uesaka, Katsuhiko, additional, Umar, Garzali, additional, Urbani, Lucio, additional, Vailas, Michail, additional, van Dam, Ronald, additional, van de Boezem, Peter, additional, van Laarhoven, Stijn, additional, Vanagas, Tomas, additional, Van Dooren, Mike, additional, Viennet, Manon, additional, Vigano, Luca, additional, Vijayashanker, Aarathi, additional, Villodre, Celia, additional, Wakai, Toshifumi, additional, Workneh, Aklile, additional, Xu, Li, additional, Yamamoto, Masakazu, additional, Yang, Zhiying, additional, Young, Robert, additional, and Zivanovic, Marko, additional

Published
2023
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22. Impact of Borderline Resectability in Pancreatic Head Cancer on Patient Survival:Biology Matters According to the New International Consensus Criteria

Author

Anger, Friedrich, Döring, Anna, van Dam, Jacob, Lock, Johan Friso, Klein, Ingo, Bittrich, Max, Germer, Christoph Thomas, Wiegering, Armin, Kunzmann, Volker, van Eijck, Casper, Löb, Stefan, Anger, Friedrich, Döring, Anna, van Dam, Jacob, Lock, Johan Friso, Klein, Ingo, Bittrich, Max, Germer, Christoph Thomas, Wiegering, Armin, Kunzmann, Volker, van Eijck, Casper, and Löb, Stefan

Abstract

Background: International consensus criteria (ICC) have redefined borderline resectability for pancreatic ductal adenocarcinoma (PDAC) according to three dimensions: anatomical (BR-A), biological (BR-B), and conditional (BR-C). The present definition acknowledges that resectability is not just about the anatomic relationship between the tumour and vessels but that biological and conditional dimensions also are important. Methods: Patients’ tumours were retrospectively defined borderline resectable according to ICC. The study cohort was grouped into either BR-A or BR-B and compared with patients considered primarily resectable (R). Differences in postoperative complications, pathological reports, overall (OS), and disease-free survival were assessed. Results: A total of 345 patients underwent resection for PDAC. By applying ICC in routine preoperative assessment, 30 patients were classified as stage BR-A and 62 patients as stage BR-B. In total, 253 patients were considered R. The cohort did not contain BR-C patients. No differences in postoperative complications were detected. Median OS was significantly shorter in BR-A (15 months) and BR-B (12 months) compared with R (20 months) patients (BR-A vs. R: p = 0.09 and BR-B vs. R: p < 0.001). CA19-9, as the determining factor of BR-B patients, turned out to be an independent prognostic risk factor for OS. Conclusions: Preoperative staging defining surgical resectability in PDAC according to ICC is crucial for patient survival. Patients with PDAC BR-B should be considered for multimodal neoadjuvant therapy even if considered anatomically resectable.

Published
2021

26. COVID-19 pandemic: implications on the surgical treatment of gastrointestinal and hepatopancreatobiliary tumours in Europe

Author

Nevermann, N F, Hillebrandt, K H, Knitter, S, Ritschl, P V, Krenzien, F, Benzing, C, Bahra, M, Biebl, M, Sauer, I M, Öllinger, R, Schöning, W, Schmelzle, M, Pratschke, J, Abu Hilal, Mohammad, Aldrighetti, Luca, Andersson, Roland, András, Vereczkei, Andreou, Andreas, Arer, İlker Murat, Atıcı, Ali Emre, Szijártó, Attila, Ayav, Ahmet, Aydın, Hüseyin Onur, Bartsch, Detlev, Belli, Andrea, Bertrand, Claude, Bockhorn, Maximilian, Bolli, Martin, Brekalo, Zdrinko, Bruns, Christiane, Ciria, Ruben, Coker, Ahmet, Croner, Roland, dHoore, Andre, Demartines, Nicolas, Demir, Ekin, Dibra, Arvin, Dilek, Osman Nuri, Dogrul, Ahmet, Efanov, Mikhail, Ekmekcigil, Ela, Ergün, Sefa, Farsi, Marco, Fichtner-Feigl, Stefan, Fretland, Åsmund, Friess, Helmut, Beets, Geerard, Gloor, Beat, Gockel, Ines, Gökakın, Ali Kağan, Gomez i Gavara, Concepción, Gretschel, Stephan, Hackl, Christina, Hecker, Andreas, Heinrich, Stefan, Huber, Tobias, Ibis, Cem, Izbicki, Jakob R, Kahlert, Christoph, Kamphues, Carsten, Kapan, Selin, Kazemier, Geert, Kleeff, Joerg, Klink, Christian, Knoefel, Wolfram, Kosieradzki, Maciej, Kube, Rainer, Löb, Stefan, Maagaard Andersen, Lars, Matthaei, Hanno, Mittler, Jens, Morgul, Mehmet Haluk, Moszkowicz, David, Musanovic, Nermin, Nickel, Felix, Nilsson, Magnus, Öfner, Dietmar, Oruğ, Taner, Pascher, Andreas, Pessaux, Patrick, Radionov, Michail, Raraty, Michael, Reissfelder, Christoph, Rhaiem, Rami, Rotellar, Fernando, Ryska, Miroslav, López-Ben, Santiago, Saribeyoglu, Kaya, Schafmayer, Clemens, Schmelzle, Moritz, Schmidt, Thomas, Schneider, Martin, Schoenberg, Markus, Schöning, Wenzel, Seehofer, Daniel, Sönmez, Recep Erçin, Soubrane, Olivier, Stange, Daniel, Strücker, Benjamin, Tursunovic, Amir, Tüzüner, Acar, Vondran, Florian, Weber, Georg, Wellner, Ulrich, Yazici, Pinar, Yeğen, Cumhur, Yol, Sinan, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), COVID‐19 Surgical Oncology Collaboration Group, Nevermann, N. F., Hillebrandt, K. H., Knitter, S., Ritschl, P. V., Krenzien, F., Benzing, C., Bahra, M., Biebl, M., Sauer, I. M., Ollinger, R., Schoning, W., Schmelzle, M., Pratschke, J., Abu Hilal, M., Aldrighetti, L., Andersson, R., Andras, V., Andreou, A., Arer, I. M., Atici, A. E., Szijarto, A., Ayav, A., Aydin, H. O., Bartsch, D., Belli, A., Bertrand, C., Bockhorn, M., Bolli, M., Brekalo, Z., Bruns, C., Ciria, R., Coker, A., Croner, R., D'Hoore, A., Demartines, N., Demir, E., Dibra, A., Dilek, O. N., Dogrul, A., Efanov, M., Ekmekcigil, E., Ergun, S., Farsi, M., Fichtner-Feigl, S., Fretland, A., Friess, H., Beets, G., Gloor, B., Gockel, I., Gokakin, A. K., Gomez i Gavara, C., Gretschel, S., Hackl, C., Hecker, A., Heinrich, S., Huber, T., Ibis, C., Izbicki, J. R., Kahlert, C., Kamphues, C., Kapan, S., Kazemier, G., Kleeff, J., Klink, C., Knoefel, W., Kosieradzki, M., Kube, R., Lob, S., Maagaard Andersen, L., Matthaei, H., Mittler, J., Morgul, M. H., Moszkowicz, D., Musanovic, N., Nickel, F., Nilsson, M., Ofner, D., Orug, T., Pascher, A., Pessaux, P., Radionov, M., Raraty, M., Reissfelder, C., Rhaiem, R., Rotellar, F., Ryska, M., Lopez-Ben, S., Saribeyoglu, K., Schafmayer, C., Schmidt, T., Schneider, M., Schoenberg, M., Seehofer, D., Sonmez, R. E., Soubrane, O., Stange, D., Strucker, B., Tursunovic, A., Tuzuner, A., Vondran, F., Weber, G., Wellner, U., Yazici, P., Yegen, C., Yol, S., UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de chirurgie

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, MEDLINE, Surveys and Questionnaires, Correspondence, Pandemic, Humans, Medicine, General, Surgical treatment, Intensive care medicine, Referral and Consultation, Pandemics, Gastrointestinal Neoplasms, SARS-CoV-2, business.industry, Liver Neoplasms, COVID-19, Liver Transplantation, Europe, Pancreatic Neoplasms, Biliary Tract Neoplasms, Surgical Oncology, Italy, Surgical Procedures, Operative, Surgery, Coronavirus Infections, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Published
2020
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28. Impact of Borderline Resectability in Pancreatic Head Cancer on Patient Survival: Biology Matters According to the New International Consensus Criteria

Author

Anger, Friedrich, primary, Döring, Anna, additional, van Dam, Jacob, additional, Lock, Johan Friso, additional, Klein, Ingo, additional, Bittrich, Max, additional, Germer, Christoph-Thomas, additional, Wiegering, Armin, additional, Kunzmann, Volker, additional, van Eijck, Casper, additional, and Löb, Stefan, additional

Published
2020
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33. Suprapubic bladder drainage and epidural catheters following abdominal surgery-A risk for urinary tract infections?

Author

Wagner, Johanna, Eiken, Barbara, Haubitz, Imme, Lichthardt, Sven, Matthes, Niels, Löb, Stefan, Klein, Ingo, Germer, Christoph-Thomas, and Wiegering, Armin

Subjects
Male, urologic and male genital diseases, Epidural Block, Catheters, Indwelling, Risk Factors, Anesthesiology, Germany, Surveys and Questionnaires, Medicine and Health Sciences, Anesthesia, Postoperative Period, Pharmaceutics, Middle Aged, Cystostomy, Abdominal Surgery, Urinary Tract Infections, Drainage, Engineering and Technology, Medicine, Female, Anatomy, Urinary Catheterization, Research Article, Biotechnology, Adult, Anesthesia, Epidural, Catheters, Bladder, Urology, Science, Urinary Bladder, Bioengineering, Surgical and Invasive Medical Procedures, Urinary Catheters, Catheterization, Drug Therapy, Humans, ddc:610, Device Removal, Aged, Retrospective Studies, Postoperative Care, Rectum, Biology and Life Sciences, Renal System, Urinary Retention, Gastrointestinal Tract, Medical Devices and Equipment, Local and Regional Anesthesia, Digestive System
Abstract

BackgroundEpidural catheters are state of the art for postoperative analgesic in abdominal surgery. Due to neurolysis it can lead to postoperative urinary tract retention (POUR), which leads to prolonged bladder catheterization, which has an increased risk for urinary tract infections (UTI). Our aim was to identify the current perioperative management of urinary catheters and, second, to identify the optimal time of suprapubic bladder catheter removal in regard to the removal of the epidural catheter.MethodsWe sent a questionnaire to 102 German hospitals and analyzed the 83 received answers to evaluate the current handling of bladder drainage and epidural catheters. Then, we conducted a retrospective study including 501 patients, who received an epidural and suprapubic catheter after abdominal surgery at the University Hospital Würzburg. We divided the patients into three groups according to the point in time of suprapubic bladder drainage removal in regard to the removal of the epidural catheter and analyzed the onset of a UTI.ResultsOur survey showed that in almost all hospitals (98.8%), patients received an epidural catheter and a bladder drainage after abdominal surgery. The point in time of urinary catheter removal was equally distributed between before, simultaneously and after the removal of the epidural catheter (respectively: ~28-29%). The retrospective study showed a catheter-associated UTI in 6.7%. Women were affected significantly more often than men (10,7% versus 2,5%, pConclusionThe point in time of suprapubic bladder drainage removal in relation to the removal of the epidural catheter does not seem to correlate with the rate of UTIs. The current handling in Germany is inhomogeneous, so further studies to standardize treatment are recommended.

Published
2019

36. Die Akkumulation von Laktat im Rahmen der Wundheilung stimuliert die Expression von Schlüsselgenen für das Homing mesenchymaler Stammzellen

Author

Zieker, Derek, Löffler, Markus, Königsrainer, Ingmar, Löb, Stefan, Glatzle, Jörg, Königsrainer, Alfred, Northoff, Hinnak, and Beckert, Stefan

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Im Verlauf der Wundheilung akkumulieren hohe Konzentrationen an Laktat im Gewebe. Es konnte gezeigt werden, dass sich in experimentellen Wunden durch exogene Zugabe von Laktat eine erhöhte Anzahl von Stammzellen detektieren lässt. Ob es sich dabei um ein Einwandern von Stammzellen[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2010
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38. Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejection

Author

Lahdou, Imad, primary, Sadeghi, Mahmoud, additional, Daniel, Volker, additional, Schenk, Martin, additional, Renner, Fabrice, additional, Weimer, Rolf, additional, Löb, Stefan, additional, Schmidt, Jan, additional, Mehrabi, Arianeb, additional, Schnitzler, Paul, additional, Königsrainer, Alfred, additional, Döhler, Bernd, additional, Opelz, Gerhard, additional, and Terness, Peter, additional

Published
2010
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42. Morbid Obesity and Subsequent Pancreatic Cancer: Pylorus-Preserving Pancreatoduodenectomy after Laparoscopic Sleeve Gastrectomy

Author

Küper, Markus A., primary, Königsrainer, Ingmar, additional, Schmidt, Diethard, additional, Kramer, K. Michael, additional, Granderath, Frank A., additional, Schneider, Joachim, additional, Löb, Stefan, additional, Zieker, Derek, additional, Hartmann, Jörg T., additional, Zdichavsky, Marty, additional, Königsrainer, Alfred, additional, and Brücher, Björn L. D. M., additional

Published
2008
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46. Simvastatin reduces tumor cell adhesion to human peritoneal mesothelial cells by decreased expression of VCAM-1 and β1 integrin.

Author

Wagner BJ, Löb S, Lindau D, Hörzer H, Gückel B, Klein G, Glatzle J, Rammensee HG, Brücher BL, and Königsrainer A

Subjects
Cell Line, Tumor, Female, Gene Expression Regulation drug effects, HT29 Cells, Humans, Integrin beta1 genetics, Intercellular Adhesion Molecule-1 genetics, Intercellular Adhesion Molecule-1 metabolism, Ligands, Ovarian Neoplasms genetics, Ovarian Neoplasms metabolism, Protein Binding, Vascular Cell Adhesion Molecule-1 genetics, Antineoplastic Agents pharmacology, Cell Adhesion drug effects, Integrin beta1 metabolism, Peritoneum cytology, Peritoneum metabolism, Simvastatin pharmacology, Vascular Cell Adhesion Molecule-1 metabolism
Abstract

Peritoneal carcinomatosis describes cancer metastasis onto the surface of the peritoneum. It is frequently caused by ovarian and colorectal cancer. Once a tumor has penetrated the peritoneum, cancer cells disseminate into the abdominal cavity. Additionally, surgery can account for the spread of free tumor cells. Their subsequent adhesion to mesothelial cells (HMCs) initiates peritoneal carcinomatosis. Therefore, this study analyzed the effect of simvastatin on tumor cell adherence. HMCs were isolated from human greater omentum. Fluorescence-labeled tumor cells (SKOV-3, OvCar-29, OAW42, FraWü; ovarian/HT29; colorectal) were incubated on confluent mesothelial monolayers with 10 µM simvastatin for 48 h. Adhesion was quantified using a fluorescence reader. Expression of the adhesion molecules VCAM-1, ICAM-1 and β1 integrin chain under the influence of simvastatin 0.1-100 µM for 24-72 h was analyzed using flow cytometry. Simvastatin significantly reduced the adhesion of all ovarian cancer cells and HT29 to HMCs (P≤0.001). Concomitantly simvastatin decreased the expression of VCAM-1 on HMCs. ICAM-1 and β1 integrin chain expression on ovarian cancer cells was also clearly reduced. By contrast, the expression of the analyzed adhesion molecules on HT29 cells remained unchanged. Simvastatin clearly inhibits tumor cell adhesion to HMCs. In the case of ovarian cancer cell lines it appears to be mediated by decreased expression of both VCAM-1 on HMCs and the integrin α4β1 on tumor cells. As an example of adhesion molecule down-regulating drugs, simvastatin may provide a novel therapeutic approach to the prevention of peritoneal carcinomatosis.

Published
2011
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47. Predictive value of routine transcutaneous tissue oxygen tension (tcpO2) measurement for the risk of non-healing and amputation in diabetic foot ulcer patients with non-palpable pedal pulses.

Author

Ladurner R, Küper M, Königsrainer I, Löb S, Wichmann D, Königsrainer A, Coerper S, and Beckert S

Subjects
Adult, Aged, Aged, 80 and over, Diabetic Foot blood, Diabetic Foot diagnosis, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Risk, Time Factors, Treatment Outcome, Wound Healing, Amputation, Surgical, Diabetic Foot physiopathology, Diabetic Foot therapy, Oxygen blood
Abstract

Background: It was evaluated whether transcutaneous tissue oxygen tension (tcpO2) measurement, when assessed in daily routine, can be used to predict the risk of non-healing and amputation in diabetic foot ulcer patients with non-palpable pedal pulses., Material/methods: Patients were followed up in an outpatient setting according to a comprehensive wound-care protocol. tcpO2 measurements were performed at the dorsum of the forefoot in a standardized setting. Patients were divided into three subgroups according to their initial tcpO2-readings (tcpO2 <20 mmHg, tcpO2 20-40 mmHg, tcpO2 >40 mmHg). Patients with clinical signs of soft tissue infection at the initial presentation were excluded., Results: One hundred forty-one patients were enrolled. Wounds associated with a tcpO2 reading <20 mmHg demonstrated a significantly decreased probability of healing compared with those associated with a tcpO2 >40 mmHg (p=0.008). In addition, the risks of soft tissue infection (p=0.057) and hospitalization during follow-up (p=0.019) were different among the three groups. The overall amputation rate increased with decreasing tcpO2 (p=0.014) although there was no significant difference for major amputations (p=0.448)., Conclusions: Routine assessment of tcpO2 is suitable as a clinical screening tool for estimating the risk of non-healing in diabetic foot ulcer patients without palpable pedal pulses. However, its predictive value for the risk of amputation remains unclear.

Published
2010

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