71 results on '"López-Plaza B"'
Search Results
2. Impact of an oral nutritional supplement with bioactive compounds on improving nutritional status, body composition and quality of life in cancer patients: The ALISENOC study
- Author
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Vidal Casariego, A., primary, García Luna, P.P., additional, Villazón González, F., additional, Martín Folgueras, T., additional, Palma Milla, S., additional, Izaola Jáuregui, O., additional, Roque Cuéllar, C., additional, Rodríguez Lavandeira, U., additional, López Plaza, B., additional, Casañas-Quintana, T., additional, Calleja Fernández, A., additional, and de Luis Román, D.A., additional
- Published
- 2023
- Full Text
- View/download PDF
3. Impact of nutritional supplementation with bioactive compounds on improving the intake of cancer patients: The Alisenoc study
- Author
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Palma Milla, S., primary, García Luna, P.P., additional, Vidal Casariego, A., additional, Villazón González, F., additional, Martín Folgueras, T., additional, Primo Martín, D., additional, García Rey, S., additional, Rodríguez Lavandeira, U., additional, López Plaza, B., additional, Casañas-Quintana, T., additional, Calleja Fernández, A., additional, and de Luis Román, D.A., additional
- Published
- 2023
- Full Text
- View/download PDF
4. Validation of glim criteria as a method for nutritional diagnosis in the routine clinical practice of a third-level hospital
- Author
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De Leon, B., primary, Palma-Milla, S., additional, López-Plaza, B., additional, Clavero-Fraile, M., additional, Morato-Martínez, M., additional, Salazar-González, J.J., additional, Pulido-Vega, M., additional, and Gómez-Candela, C., additional
- Published
- 2021
- Full Text
- View/download PDF
5. Validation of glim criteria as a method for nutritional diagnosis in different age groups in the routine clinical practice of a third-level hospital
- Author
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De Leon, B., primary, Palma-Milla, S., additional, López-Plaza, B., additional, Clavero-Fraile, M., additional, Morato-Martínez, M., additional, Salazar-González, J.J., additional, García-Gutiérrez, C., additional, and Gómez-Candela, C., additional
- Published
- 2021
- Full Text
- View/download PDF
6. The automatic nutritional risk screening system (conut) predicts the mortality risk of Covid-19 patients
- Author
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Palma-Milla, S., primary, López-Plaza, B., additional, Morato-Martínez, M., additional, De León, B., additional, Jiménez-González, M., additional, Monserrat-Villatoro, J., additional, Borobia, A., additional, and Gómez-Candela, C., additional
- Published
- 2021
- Full Text
- View/download PDF
7. Changes in folate status in overweight/obese women following two different weight control programmes based on an increased consumption of vegetables or fortified breakfast cereals
- Author
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Ortega, R. M., López-Sobaler, A. M., Andrés, P., Rodríguez-Rodríguez, E., Aparicio, A., Bermejo, L. M., and López-Plaza, B.
- Published
- 2006
8. Impact of cooked functional meat enriched with omega-3 fatty acids and rosemary extract on inflammatory and oxidative status: a randomised, double-blind, crossover study
- Author
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Bermejo, L.M., López-Plaza, B., Weber, T.K., Palma-Milla, S., Iglesias, C., Reglero, G., and Gómez-Candela, C.
- Subjects
Anti-inflammatory agents ,Alimento funcional ,Marcadores antiinflamatorios ,Acidos grasos omega-3 ,Functional food ,Omega-3 fatty acids ,Antioxidantes ,Antioxidants ,Rosmarinus - Abstract
Background & Aim: n-3 fatty acid intake has been associated with inflammatory benefits in cardiovascular disease (CVD). Functionalising meat may be of great interest. The aim of the present study was to assess the effect of functional meat containing n-3 and rosemary extract on inflammatory and oxidative status markers in subjects with risk for CVD. Methods and results: A randomised, double-blind, cross-over study was undertaken to compare the effects on the above markers of consuming functional or control meat products. 43 volunteers with at least two lipid profile variables showing risk for CVD were randomly assigned to receive functional meat (FM) or control meat (CM) over 12-weeks with a 4-week wash-out interval before crossover. Functional effects were assessed by examining lipid profile, CRP, PAI-1, TNF-alpha, IL-6, fibrinogen (inflammatory markers), and TBARS, FRAP and 8-iso-PGF2α (oxidative status markers). 33 subjects (24 women) aged 50.7±8.8 years completed the study. In FM treatment, PAI-1, fibrinogen and 8-iso-PGF2α decreased significantly after 12 weeks, while FRAP significantly increased. In contrast, in CM treatment, a significant increase was seen in PAI-1, while FRAP significantly declined. Significant differences were also seen between the FM and CM treatments after 12 weeks in terms of the change observed in PAI-1, FRAP and 8-iso-PGF2α values. No significant differences were seen in anthropometric variables nor were adverse effects reported. Conclusion: The consumption of FM containing n-3 and rosemary extract improved oxidative and inflammatory status of people with at least two lipid profile variables showing risk for CVD. The inclusion of such functional meat in a balanced diet might be a healthy lifestyle option. ClinicalTrials.gov NCT0199088. Objetivos: La ingesta de omega-3 se ha asociado con efectos antinflamatorios relacionados con la prevención de la enfermedad cardiovascular (ECV). Desarrollar productos cárnicos funcionales podría ser de gran interés para la población. El objetivo del presente estudio fue evaluar el efecto de una carne funcional con omega-3 y extracto de romero sobre marcadores de inflamación y oxidación en personas con riesgo cardiovascular. Pacientes y métodos: Se diseñó un ensayo clínico cruzado y doble-ciego para estudiar el efecto del consumo de un producto cárnico funcional sobre marcadores de inflamación y oxidación. Se incluyeron 43 voluntarios con al menos 2 parámetros del perfil lipídico alterado, indicando riesgo de ECV. Fueron asignados aleatoriamente en 2 grupos que consumieron en cruzado carne funcional (CF) o carne control (CC) durante 12 semanas con un periodo de lavado de 4 semanas entre ellos. Al finalizar el estudio se evaluó: perfil lipídico, marcadores de inflamación (PCR, PAI-1, TNF-alpha, IL-6, fibrinógeno) y marcadores de oxidación (TBARS, FRAP, 8-iso-PGF2α). Resultados: Completaron el estudio 33 personas (24 mujeres) con edad media de 50.7±8.8 años. Tras consumir CF durante 12 semanas se observó una disminución significativa del PAI-1, fibrinógeno y 8-iso-PGF2α, mientras que el FRAP incrementó significativamente. Sin embargo, con CC incrementó PAI-1 y disminuyó FRAP significativamente. Además se observaron diferencias significativas entre los cambios producidos tras consumir uno u otro producto de los marcadores PAI-1, FRAP y 8-iso-PGF2α. Al final de cada intervención no se observaron cambios en variables antropométricas ni efectos adversos. Conclusiones: El consumo de CF con omega-3 y extracto de romero mejora el estado inflamatorio y oxidativo de personas con al menos 2 parámetros del perfil lipídico alterado. La inclusión de estas CF en una dieta equilibrada podría ser una opción más para mantener un estilo de vida saludable. ClinicalTrials.gov NCT0199088.
- Published
- 2014
9. Impact of ADRB3 SNP on abdominal fat in overweight and obese women
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Szendrei Szabo, Barbara, Cupeiro Coto, Rocío, Amigo, T., González Lamuno, D., Gómez, C., López Plaza, B., Peinado Lozano, Ana Belen, and Calderón Montero, Francisco Javier
- Subjects
Medicina ,Deportes - Abstract
Ponencia sobre el efecto de un polimorfismo del gen ADRB3 sobre masa grasa en mujeres con sobrepeso y obesidad.
- Published
- 2014
10. Ingesta y fuentes de calcio en una muestra representativa de escolares españoles
- Author
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Ortega, R. M., López-Sobaler, A. M., Jiménez Ortega, A. I., Navia Lombán, B., Ruiz-Roso Calvo de Mora, B., Rodríguez-Rodríguez, E., and López Plaza, B.
- Subjects
Calcio ,Ingestas insuficientes ,Escolares ,Schoolchildren ,Insufficient intake ,Muestra representativa ,Calcium ,Representative sample ,Lácteos ,Dairy products - Abstract
Introducción: La adecuación de la ingesta de calcio de la población infantil española ha sido objeto de debate y controversia, pues algunos estudios señalan que puede ser inadecuada en un porcentaje variable de escolares, mientras que algunos documentos insisten en el peligro de una ingesta excesiva en un amplio porcentaje de la población escolar. Objetivos: Valorar la ingesta de calcio y las fuentes alimentarias de este nutriente en una muestra representativa de niños españoles, analizando también la adecuación del aporte a la cobertura de las ingestas recomendadas. Métodos: Se estudiaron 903 escolares (de 7 a 11 años) de diez provincias españolas: Tarragona, Cáceres, Burgos, Guadalajara, Valencia, Salamanca, Córdoba, Vizcaya, Lugo y Madrid, que constituyen una muestra representativa de la población española de dicha edad. La ingesta de energía y nutrientes se determinó utilizando un registro del consumo de alimentos durante 3 días, incluyendo un domingo. El aporte de calcio se comparó con las Ingestas Recomendadas (IR) marcadas para dicho mineral. Los parámetros antropométricos estudiados fueron el peso y la talla, lo que permitió calcular el índice de masa corporal (IMC). Resultados: En el colectivo estudiado (55,3% de niñas y 44,7% de niños), un 30,7% presentó exceso de peso (sobrepeso-23,3% y obesidad-7,4%). La ingesta de calcio de los niños estudiados (859,9 ± 249,2 mg/día) supuso un 79,5% de lo recomendado, observándose la existencia de un 76,7% de niños con ingestas menores de las recomendadas y un 40,1 con ingestas < 67% de las IR. La relación calcio/fósforo (0,74 ± 0,21), calcio/proteínas (10,1 ± 2,8) y el índice de calidad nutricional para el calcio (0,78 ± 0,29) estuvieron por debajo de lo recomendado en el 91,6%, 99,8% y 81,1% de los niños, respectivamente. En relación con la procedencia alimentaria del calcio, un 64,7% proviene de lácteos, 7,6% de varios, 7,3% de cereales, 3,5% de verduras, 3,4% de frutas y 3,3% de precocinados, las carnes y pescados aportan un 2,8%, cada grupo y las legumbres un 2,2%, sin diferencias en función del sexo. Conclusión: La ingesta de calcio es inferior a la recomendada en un elevado porcentaje de los estudiados (76,7%) y resulta en un 40,1% claramente insuficiente (< 67%de IR). Teniendo en cuenta que en la dieta media infantil española el aporte de calcio proviene mayoritariamente de los lácteos (64,7%), aumentar el consumo de este grupo de alimentos resulta deseable, especialmente en el 37,1% de los niños que no toman el mínimo de las 2 raciones/día, recomendadas. Introduction: There is controversy about the adequacy of calcium intake to that recommended in Spanish schoolchildren. Some studies indicate that the intake is inadequate in a variable percentage of children, while others insist on the danger of an excessive intake in a huge percentage of this population. Aim: To assess calcium intake and food sources of this nutrient in a representative sample of Spanish children and to judge the adequacy of its contribution to the coverage of recommended intakes. Methods: 903 schoolchildren (7 to 11 years) from 10 Spanish provinces (Tarragona, Caceres, Burgos, Guadalajara, Valencia, Salamanca, Cordoba, Vizcaya, Lugo and Madrid) were studied. They constituted a representative sample of the Spanish schoolchildren population. The energy and nutrient intake was determined using a "Food record questionnaire" for 3 days, including a Sunday. Calcium intake was compared with the recommended intakes (RI) for the mineral. Weight and height were recorded and body mass index (BMI) calculated. Results: In the studied group (55.3% girls and 44.7% of children), 30.7% had an excess body weight (23.3% overweight and 7.4% obesity). Calcium intake was 859.9 ± 249.2 mg / day (79.5% of the recommendations). 76.7% of children had intakes below 100% of those recommended and 40.1% below of 67% of RI. The ratios calcium/phosphorus (0.74 ± 0.21) and calcium/protein (10.1 ± 2.8) and the index of nutritional quality for calcium (0.78 ± 0.29) were lower than recommended in 91.6%, 99.8% and 81.1% of children, respectively. Dietary calcium came from dairy products (64.7%), dietetic products and infant formulae (7.6%), cereals (7.3%), vegetables (3.5%), fruits (3.4%), pre-cooked meals (3.3%), meats (2.8%), fishes (2.8%) and pulses (2.2%), with no differences by gender. Conclusion: Calcium intake was lower than recommended in 76.7% of the children and 40.1% had insufficient intake (< 67% of RI). Having in mind that the main calcium source was dairy products (64.7%), increase consumption of this food group is recommended, especially in the 37.1% of children who did not reach the 2 recommended servings per day.
- Published
- 2012
11. Ingesta y fuentes de calcio en una muestra representativa de escolares españoles
- Author
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Ortega,R. M., López-Sobaler,A. M., Jiménez Ortega,A. I., Navia Lombán,B., Ruiz-Roso Calvo de Mora,B., Rodríguez-Rodríguez,E., and López Plaza,B.
- Subjects
Calcio ,Ingestas insuficientes ,Escolares ,Muestra representativa ,Lácteos - Abstract
Introducción: La adecuación de la ingesta de calcio de la población infantil española ha sido objeto de debate y controversia, pues algunos estudios señalan que puede ser inadecuada en un porcentaje variable de escolares, mientras que algunos documentos insisten en el peligro de una ingesta excesiva en un amplio porcentaje de la población escolar. Objetivos: Valorar la ingesta de calcio y las fuentes alimentarias de este nutriente en una muestra representativa de niños españoles, analizando también la adecuación del aporte a la cobertura de las ingestas recomendadas. Métodos: Se estudiaron 903 escolares (de 7 a 11 años) de diez provincias españolas: Tarragona, Cáceres, Burgos, Guadalajara, Valencia, Salamanca, Córdoba, Vizcaya, Lugo y Madrid, que constituyen una muestra representativa de la población española de dicha edad. La ingesta de energía y nutrientes se determinó utilizando un registro del consumo de alimentos durante 3 días, incluyendo un domingo. El aporte de calcio se comparó con las Ingestas Recomendadas (IR) marcadas para dicho mineral. Los parámetros antropométricos estudiados fueron el peso y la talla, lo que permitió calcular el índice de masa corporal (IMC). Resultados: En el colectivo estudiado (55,3% de niñas y 44,7% de niños), un 30,7% presentó exceso de peso (sobrepeso-23,3% y obesidad-7,4%). La ingesta de calcio de los niños estudiados (859,9 ± 249,2 mg/día) supuso un 79,5% de lo recomendado, observándose la existencia de un 76,7% de niños con ingestas menores de las recomendadas y un 40,1 con ingestas < 67% de las IR. La relación calcio/fósforo (0,74 ± 0,21), calcio/proteínas (10,1 ± 2,8) y el índice de calidad nutricional para el calcio (0,78 ± 0,29) estuvieron por debajo de lo recomendado en el 91,6%, 99,8% y 81,1% de los niños, respectivamente. En relación con la procedencia alimentaria del calcio, un 64,7% proviene de lácteos, 7,6% de varios, 7,3% de cereales, 3,5% de verduras, 3,4% de frutas y 3,3% de precocinados, las carnes y pescados aportan un 2,8%, cada grupo y las legumbres un 2,2%, sin diferencias en función del sexo. Conclusión: La ingesta de calcio es inferior a la recomendada en un elevado porcentaje de los estudiados (76,7%) y resulta en un 40,1% claramente insuficiente (< 67%de IR). Teniendo en cuenta que en la dieta media infantil española el aporte de calcio proviene mayoritariamente de los lácteos (64,7%), aumentar el consumo de este grupo de alimentos resulta deseable, especialmente en el 37,1% de los niños que no toman el mínimo de las 2 raciones/día, recomendadas.
- Published
- 2012
12. Prevalencia de sobrepeso y obesidad en adultos españoles
- Author
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Rodríguez-Rodríguez, E., López-Plaza, B., López-Sobaler, A. M.ª, and Ortega, R. M.ª
- Subjects
Spain ,Sobrepeso ,España ,Obesidad ,Prevalence ,Adults ,Adultos ,Obesity ,Overweight ,Prevalencia - Abstract
Objetivo: Evaluar la prevalencia de sobrepeso y obesidad en adultos españoles y comprobar cuál es la situación actual y cómo ha evolucionado en los últimos años. Material y métodos: Se ha estudiado un colectivo de 418 individuos (196 varones y 222 mujeres) de 18 a 60 años, que fueron seleccionados para constituir una muestra representativa de la población española en su conjunto. Se han registrado datos sanitarios, socioeconómicos y antropométricos (peso, talla, circunferencia de la cintura y porcentaje de grasa corporal mediante bioimpedancia). Se ha calculado el Índice de Masa Corporal y la relación cintura/altura. Resultados: La prevalencia de sobrepeso en la población fue del 34,2%, siendo mayor en los varones (43,9%) que en las mujeres (25,7%); y la de obesidad fue del 13,6%, sin existir diferencias entre sexos. Un 47,8% de la población presentó sobrecarga ponderal y un 70,2% exceso de grasa corporal, siendo mayor en varones que en mujeres y aumentando estos parámetros con la edad. Un 22,2% de la población estudiada presentó obesidad central (tomando como referencia la circunferencia de la cintura) y un 54,7% obesidad central y riesgo cardiovascular (al presentar relaciones cintura/altura > 0,5), siendo mayores ambos parámetros en el grupo de los varones. Conclusión: La población española se encuentra en una situación alarmante con respecto al padecimiento de sobrepeso y obesidad, presentando más de la mitad de la población riesgo de padecer enfermedad cardiovascular. Además, la situación ha empeorado con respecto a datos obtenidos en estudios anteriores, por lo que hay que seguir trabajando para disminuir su prevalencia. Aim: to assess the prevalence of overweight and obesity in Spanish adults and to know the current situation and its evolution in the last years. Material and methods: The study involved 418 subjects (196 men and 222 women) from 18 to 60 years, who were selected to constitute a representative sample of the Spanish population as a whole. Sanitary, socioeconomic and anthropometric (weight, height, waist circumference and percentage body fat by bioimpedance) data was collected. Body Mass Index and waist-height were ratio calculated. Results: The prevalence of overweight was 34.2%, 43.9% in men and 25.7% in women, and the prevalence of obesity was 13.6% (it was similar in men and women). 47.8% of the population had excess of body weight and 70.2% excess of body fat, these parameters were higher in men than in women and they increased with age. 22.2% of the population had central obesity (taking waist circunference as reference) and 54.7% central obesity and high cardiovascular risk (because waist/height was > 0.5), both parameters were higher in men than in women. Conclusion: Overweight and obesity prevalence among the Spanish population is very high and more than the half of the population is in risk of suffering from cardiovascular disease. Furthermore, the situation is worse than a few years ago, so it is necessary to continue working to decrease the prevalence of overweight and obesity among the Spanish population.
- Published
- 2011
13. [Response to a weight control program based on approximating the diet to its theoretical ideal]
- Author
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Rm, Ortega, Ana M López-Sobaler, Rodríguez Rodríguez E, Lm, Bermejo, García González L, and López Plaza B
- Subjects
Adult ,Weight Loss ,Humans ,Female ,Obesity - Abstract
Obesity is a risk factor for a number of degenerative diseases common in industrial societies and the number of overweight/obese people continues to grow. The control of body weight is therefore a priority public health objective.To analyze the response to a weight loss program based on approximating the diet to the theoretical ideal (by increasing the consumption of recommended foods under-represented in the diet: cereals and vegetables).The study involved 67 women aged between 20 and 35 years with a body mass index (BMI) of between 24 and 35 kg/m2. These women were randomly assigned to two groups with the aim of improving weight control and of approximating the diet to the theoretical ideal.Both groups were advised to follow a slightly hypocaloric diet, but with one group increasing the intake of greens and vegetables (H) and the other increasing the intake of cereals (especially breakfast cereals) (C). Dietary data were obtained via the keeping of a daily food record over three days, including a Sunday. Anthropometric data were obtained at the start of the study and again 2 and 6 weeks later.Both treatments approximated the energy profile of the diets to the theoretical ideal. The amount of energy gained from lipids fell and that gained from carbohydrates increased (both at 2 and 6 weeks), significantly more so for group C. Fifty seven women completed the study and showed a mean reduction in body weight of 2.4 +/-1.4 kg. The weight lost by group C was significantly greater than that lost by group H (2.8 +/- 1.4 kg compared to 2.0 +/- 1.3 kg; p0.05). The women who followed diet C showed a greater number of skin folds of significantly reduced size, both at 2 and 6 weeks. More group C women completed the study (93.5% compared to 77.8% of group H women).In overweight or slightly obese women, approximating the diet to the theoretical ideal (by increasing the intake of vegetables of cereals) can help to control body weight and improve the quality of the diet (both in terms of the number and size of food rations, and the overall energy profile). The present results show that increasing the consumption of breakfast cereals may be of particular use owing to their high fiber, vitamin and iron contents.
- Published
- 2005
14. Response to a weight control program based on aproximating the diet to its theoretical ideal
- Author
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Ortega,R. M., López-Sobaler,A. M., Rodríguez Rodríguez,E., Bermejo,L. M., García González,L., and López Plaza,B.
- Subjects
vegetables ,obesity ,Verduras/hortalizas ,Cereales de desayuno ,Obesidad ,weight ,Mujeres ,improvement of diet quality ,Peso ,breakfast cereals ,Sobrepeso ,overweight ,women ,Mejora de la calidad de la dieta - Abstract
El control de peso corporal es uno de los objetivos sanitarios prioritarios, por ser la obesidad un factor de riesgo de diversas enfermedades degenerativas, frecuentes en sociedades desarrolladas, y por el incremento constante en el número de personas con sobrepeso/obesidad que deben hacer frente a este problema. Objetivo: Analizar la respuesta ante un programa de pérdida de peso basado en la aproximación de la dieta al ideal teórico (incrementando el consumo de los alimentos para los que se observa mayor alejamiento entre consumo real y aconsejado: cereales y verduras). Sujetos: Se ha estudiado un colectivo de 67 mujeres de 20 a 35 años y con índice de masa corporal (IMC) comprendido entre 24 y 35 kg/m2, que después de realizar un estudio inicial, fueron incluidas al azar en dos grupos encaminados a conseguir un mejor control del peso corporal y a aproximar la dieta al ideal teórico. Intervenciones: En ambos grupos se aconsejó una dieta ligeramente hipocalórica, pero en uno de ellos la pauta principal era el seguimiento de una dieta con mayor contenido en verduras y hortalizas (H), y en el otro grupo se aconsejó un incremento en el consumo de cereales (especialmente cereales de desayuno) (C). En el presente estudio se presentan datos dietéticos (obtenidos por "Registro del consumo de alimentos" durante 3 días, incluyendo un domingo) y antropométricos, obtenidos al comienzo del estudio, y a las 2 y 6 semanas de iniciar la intervención. Resultados: Con ambos tipos de intervención se consiguió una aproximación del perfil calórico de las dietas al ideal aconsejado, con disminución de la cantidad de energía procedente de grasa y aumento de la procedente de hidratos de carbono (tanto en la semana 2, como en la 6), aunque la modificación fue estadísticamente más acusada con la dieta C. Completaron el estudio 57 mujeres que presentaron una reducción media del peso corporal de 2,4 ± 1,4 kg, siendo superior la pérdida de peso en el grupo C (2,8 ± 1,4 kg), respecto al grupo H (2,0 ± 1,3 kg) (p < 0,05). En las mujeres que siguieron dieta C fue mayor el número de pliegues que experimentaron una reducción estadísticamente significativa, tanto en la 2ª como en la 6ª semana, respecto a las mujeres con dieta H. El porcentaje de mujeres que concluyó el estudio también fue más elevado entre las incluidas en el grupo C (93,5% respecto a 77,8% en H). Conclusiones: En mujeres con sobrepeso, u obesidad ligera, la aproximación de la dieta al ideal teórico (por aumento en el consumo de verduras, o de cereales) puede ser de ayuda en el control de peso y en la mejora de la calidad de la dieta (tanto comparando las raciones de alimentos consumidas con las aconsejadas, como el perfil calórico). Teniendo en cuenta los resultados del presente estudio se considera que el aumento en el consumo de cereales de desayuno (por su contenido en fibra y por estar enriquecidos en vitaminas y hierro) puede ser de especial utilidad en estas situaciones. Obesity is a risk factor for a number of degenerative diseases common in industrial societies and the number of overweight/obese people continues to grow. The control of body weight is therefore a priority public health objective. Objective: To analyze the response to a weight loss program based on approximating the diet to the theoretical ideal (by increasing the consumption of recommended foods under-represented in the diet: cereals and vegetables). Subjects: The study involved 67 women aged between 20 and 35 years with a body mass index (BMI) of between 24 and 35 kg/m2. These women were randomly assigned to two groups with the aim of improving weight control and of approximating the diet to the theoretical ideal. Interventions: Both groups were advised to follow a slightly hypocaloric diet, but with one group increasing the intake of greens and vegetables (H) and the other increasing the intake of cereals (especially breakfast cereals) (C). Dietary data were obtained via the keeping of a daily food record over three days, including a Sunday. Anthropometric data were obtained at the start of the study and again 2 and 6 weeks later. Results: Both treatments approximated the energy profile of the diets to the theoretical ideal. The amount of energy gained from lipids fell and that gained from carbohydrates increased (bothat 2 and 6 weeks), significantly more so for group C. Fifty seven women completed the study and showed a mean reduction in body weight of 2.4 ± 1.4 kg. The weight lost by group C was significantly greater than that lost by group H (2.8 ± 1.4 kg compared to 2.0 ± 1.3 kg; p < 0.05). The women who followed diet C showed a greater number of skin folds of significantly reduced size, both at 2 and 6 weeks. More group C women completed the study (93.5% compared to 77.8% of group H women). Conclusion: In overweight or slightly obese women, approximating the diet to the theoretical ideal (by increasing the intake of vegetables of cereals) can help to control body weight and improve the quality of the diet (both in terms of the number and size of food rations, and the overall energy profile). The present results show that increasing the consumption of breakfast cereals may be of particular use owing to their high fiber, vitamin and iron contents.
- Published
- 2005
15. SUN-LB291: The Oral Nutritional Supplements Prescription Does Not Guarantee the Patients Consumption: New Strategies to Improve Patient Adherence
- Author
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Morato-Martinez, M., Bermejo, L.M., Lopez-Plaza, B., Valero-Perez, M., Palma-Milla, S., Pelegrina-Cortes, B., García-Vazquez, N., and Gomez-Candela, C.
- Published
- 2016
- Full Text
- View/download PDF
16. Impact of cooked functional meat enriched with omega-3 fatty acids and rosemary extract on inflammatory and oxidative status; A randomised, double-blind, crossover study.
- Author
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Bermejo, L. M., López-Plaza, B., Weber, T. K., Palma-Milla, S., Iglesias, C., Reglero, G., and Gómez-Candela, C.
- Subjects
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FUNCTIONAL foods , *OMEGA-3 fatty acids , *INFLAMMATION , *CARDIOVASCULAR diseases , *MEAT , *ANTI-inflammatory agents , *COOKING - Abstract
Background <£ Aim: n-3 fatty acid intake has been associated with inflammatory benefits in cardiovascular disease (CVD). Functionalising meat may be of great interest. The aim of the present study was to assess the effect of functional meat containing n-3 and rosemary extract on inflammatory and oxidative status markers in subjects with risk for CVD. Methods and results: A randomised, double-blind, cross-over study was undertaken to compare the effects on the above markers of consuming functional or control meat products. 43 volunteers with at least two lipid profile variables showing risk for CVD were randomly assigned to receive functional meat (FM) or control meat (CM) over 12-weeks with a 4-week wash-out interval before crossover. Functional effects were assessed by examining lipid profile, CRP, PAI-1, TNF-alpha, IL-6, fibrinogen (inflammatory markers), and TEARS, FRAP and 8-iso-PGF2a (oxidative status markers). 33 subjects (24 women) aged 50.7±8.8 years completed the study. In FM treatment, PAI-1, fibrinogen and 8-iso-PGF2a decreased significantly after 12 weeks, while FRAP significantly increased. In contrast, in CM treatment, a significant increase was seen in PAI-1, while FRAP significantly declined. Significant differences were also seen between the FM and CM treatments after 12 weeks in terms of the change observed in PAI-1, FRAP and 8-iso-PGF2a values. No significant differences were seen in anthropometric variables nor were adverse effects reported. Conclusion: The consumption of FM containing n-3 and rosemary extract improved oxidative and inflammatory status of people with at least two lipid profile variables showing risk for CVD. The inclusion of such functional meat in a balanced diet might be a healthy lifestyle option. ClinicalTrials.gov NCT0199088. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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17. Response to a weight control program based on approximating the diet to its theoretical ideal,Respuesta ante un programa de control de peso basado en la aproximación de la dieta al ideal teórico
- Author
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Ortega, R. M., López-Sobaler, A. M., Elena Rodriguez-Rodriguez, Bermejo, L. M., García González, L., and López Plaza, B.
18. Changes in folate status in overweight/obese women following two different weight control programmes based on an increased consumption of vegetables or fortified breakfast cereals
- Author
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Rm, Ortega, Am, López-Sobaler, Andrés P, Elena Rodriguez-Rodriguez, Aparicio A, Lm, Bermejo, and López-Plaza B
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Adult ,Anthropometry ,Diet, Reducing ,Overweight ,Eating ,Folic Acid ,Food, Fortified ,Vegetables ,Weight Loss ,Humans ,Female ,Obesity ,Edible Grain ,Homocysteine - Abstract
The modification of folate status was analysed in a group of sixty-seven overweight/obese women of childbearing age (20-35 years). Subjects were randomly assigned to one of two slightly hypocaloric diets: diet V (increased consumption of vegetables) or diet C (increased consumption of breakfast cereals). Dietetic, anthropometric and biochemical data were collected at the start of the study and again at 2 and 6 weeks. At 6 weeks a weight loss of 2.0 (sd 1.3) kg was achieved in V subjects and of 2.8 (sd 1.4) kg in C subjects (P0.05). At the start of the study, 64.2 % of all subjects had a folate intake of67 % of the recommended intake; this fell to just 3 % (7.14 % of V subjects and 0 % of C subjects) by week 6. Significant increases were only seen in C subjects in serum folate concentrations (both at 2 and 6 weeks), accompanied by a significant reduction in serum homocysteine (at week 6). Some 62.1 % of all subjects had serum folate concentrations ofor = 13.6 nmol/l (associated with a very low risk of neural tube defects) at the start of the study, while 87.0 % (85.2 % of V subjects and 88.9 % of C subjects) had concentrations ofor = 13.6 nmol/l at 6 weeks (P0.01). Increasing the relative consumption of vegetables/cereals in the context of a slightly hypocaloric diet may therefore be a good way to lose body weight. Breakfast cereals may be of special help with respect to folate status and serum homocysteine levels in overweight/obese young women following energy restriction diets.
19. Food sources and average intake of calcium in a representative sample of Spanish schoolchildren.
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Ortega RM, López-Sobaler AM, Jiménez Ortega AI, Navia Lombán B, Ruiz-Roso Calvo de Mora B, Rodríguez-Rodríguez E, López Plaza B, and Grupo de investigación n 920030
- Abstract
Introduction: There is controversy about the adequacy of calcium intake to that recommended in Spanish schoolchildren. Some studies indicate that the intake is inadequate in a variable percentage of children, while others insist on the danger of an excessive intake in a huge percentage of this population. Aim: To assess calcium intake and food sources of this nutrient in a representative sample of Spanish children and to judge the adequacy of its contribution to the coverage of recommended intakes. Methods: 903 schoolchildren (7 to 11 years) from 10 Spanish provinces (Tarragona, Caceres, Burgos, Guadalajara, Valencia, Salamanca, Cordoba, Vizcaya, Lugo and Madrid) were studied. They constituted a representative sample of the Spanish schoolchildren population. The energy and nutrient intake was determined using a 'Food record questionnaire' for 3 days, including a Sunday. Calcium intake was compared with the recommended intakes (RI) for the mineral. Weight and height were recorded and body mass index (BMI) calculated. Results: In the studied group (55.3% girls and 44.7% of children), 30.7% had an excess body weight (23.3% overweight and 7.4% obesity). Calcium intake was 859.9 ± 249.2 mg / day (79.5% of the recommendations). 76.7% of children had intakes below 100% of those recommended and 40.1% below of 67% of RI. The ratios calcium/phosphorus (0.74 ± 0.21) and calcium/protein (10.1 ± 2.8) and the index of nutritional quality for calcium (0.78 ± 0.29) were lower than recommended in 91.6%, 99.8% and 81.1% of children, respectively. Dietary calcium came from dairy products (64.7%), dietetic products and infant formulae (7.6%), cereals (7.3%), vegetables (3.5%), fruits (3.4%), pre-cooked meals (3.3%), meats (2.8%), fishes (2.8%) and pulses (2.2%), with no differences by gender. Conclusion: Calcium intake was lower than recommended in 76.7% of the children and 40.1% had insufficient intake (< 67% of RI). Having in mind that the main calcium source was dairy products (64.7%), increase consumption of this food group is recommended, especially in the 37.1% of children who did not reach the 2 recommended servings per day. [ABSTRACT FROM AUTHOR]
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- 2012
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20. Hydration status of cancer patients with palliative care: hydrated or dehydrated?
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Valero-Pérez, M., Morato-Martínez, M., Palma-Milla, S., López-Plaza, B., Bermejo-López, L., and Gómez-Candela, C.
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- *
HYDRATION , *CANCER patients , *DEHYDRATION - Abstract
Introduction: the relationship between thirst and dehydration in terminal patients at end of life is limited and the current bibliography agree with this controversy. Due to the lacking of scientific evidences the decision to rehydrate of these patients is based on the usual clinical practice. Objectives: to evaluate the hydration status of oncological patients with palliative care by Bioelectrical impedance analysis (BIA). Method: this scientific initiative will evaluate the hydration status of 50 oncological patients admitted with palliative care at University Hospital La Paz by BIA, excluding those who according with their Palliative- Pronostic-Score (PaP-Score) get a 30-day survival probability <30%. It is a descriptive, observational and cross-sectional study. The main variable will be the phase angle and as secondary variables: evaluation of the nutritional status by Subjective-Global-Assessment (SGA), corporal composition (BIA) and functional capability (dynamometry). Besides it will evaluate: PaP-Score, Palliative-Performance-Scale (PPS), disability (Barthel-Test), cognitive function (Pfeffer-Test), dehydration symptoms and biochemical parameters. Results: preliminary results of statistical analysis will be exposed once they achieve the estimated sample size (confidence level 95%, differences' average 0.610, DS 2,200). Conclusions: the study of the oncological with palliative care patient's hydration status provides scientific evidence to implementation of action protocols to properly rehydrate those patients. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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21. Effects of a functional yogurt enriched with soluble dietary fiber or vegetable proteins on appetite profile. An acute randomized controlled clinical trial.
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Chu Montiel D, Palma Milla S, López-Plaza B, Valero Pérez M, Gómez Candela C, and Bermejo LM
- Abstract
Introduction: designing functional foods to control appetite could be a useful strategy for managing overweight and obesity. Fiber and proteins could be interesting ingredients to consider., Objectives: to evaluate the appetite profile of two experimental yogurts (fiber-enriched [FEY] and protein-enriched [PEY]) versus a control yogurt (CY) in a group of overweight/obesity people., Material and Methods: an acute, randomized, double-blind, crossover clinical trial was carried out in a group of twelve healthy overweight/obesity type I people; randomized to consume 3 yogurts in a different order for 3 acute study days. The appetite profile (1. hunger, 2. satiety, 3. fullness, 4. prospective food consumption, 5. desire to eat something fatty, salty, sweet or savoury) was assessed using a Visual Analog Scale (ranging from 0 ''not at all'' to 10 ''extremely") at 12 moments in each acute study. Additionally, total food consumption in an ad libitum lunch was assessed., Results: FEY produce a significantly lower desire to consume any food at 30 (1.50 ± 0.42) and 60 minutes (2.78 ± 0.42) after consumption compared to PEY (3.46 ± 0.53; 4.33 ± 0.54) and CY (3.27 ± 0.69; 4.0 ± 0.78) respectively (p < 0.016). Also, FEY consumption produced a higher satiety and fullness and a lower desire to ingest something fatty, salty or savory after 90 minutes consumption compared to the other products, but the difference was not significance., Conclusion: FEY might be a good functional food prototype to control appetite in overweight and obese people.
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- 2024
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22. C-Reactive Protein-to-Prealbumin and C-Reactive Protein-to-Albumin Ratios as Nutritional and Prognostic Markers in Hospitalized Patients-An Observational Study.
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García-Moreno RM, Mola Reyes L, López-Plaza B, and Palma Milla S
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- Humans, Male, Female, Prognosis, Aged, Retrospective Studies, Middle Aged, ROC Curve, Aged, 80 and over, Prealbumin analysis, C-Reactive Protein analysis, C-Reactive Protein metabolism, Biomarkers blood, Nutrition Assessment, Nutritional Status, Serum Albumin analysis, Malnutrition diagnosis, Malnutrition blood, Hospitalization statistics & numerical data
- Abstract
This study aimed to evaluate the role of the C-reactive protein-to-prealbumin (CP) ratio and the C-reactive protein-to-albumin (CA) ratio as nutritional and prognostic markers. A retrospective study was conducted on hospitalized patients who underwent a nutritional assessment and the measurement of C-reactive protein, prealbumin, and albumin ( n = 274). Receiver operating characteristic (ROC) curve analysis was used. The area under the curve (AUC) of the CP ratio for predicting mortality was 0.644, 95%CI (0.571 to 0.717), and the CA ratio had an AUC of 0.593, 95%CI (0.518 to 0.669). The AUC of the CP ratio for the differential diagnosis between severe and moderate disease-related malnutrition (DRM) was 0.643, 95%CI (0.564 to 0.722), and the CA ratio had an AUC of 0.650, 95%CI (0.572 to 0.728). The CP and CA ratios showed greater accuracy in predicting mortality compared to C-reactive protein as an isolated marker ( p = 0.011 and p = 0.006, respectively). Both ratios also improved the ability of prealbumin and albumin to identify severe DRM ( p = 0.002 and p = 0.044, respectively). In conclusion, these results suggest that the CP and CA ratios may have a limited role in predicting mortality and identifying severe DRM by outperforming isolated protein markers.
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- 2024
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23. [Evolution of critical nutrients (salt, sugars and saturated fats) in Spanish foods and beverages in the last 25 years].
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Bermejo LM, Aparicio A, López-Plaza B, Salas-González MD, and López-Sobaler AM
- Abstract
Non-communicable diseases (cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, etc.) are the leading cause of death worldwide, accounting for 71 % of global deaths. The risk factors for all of them are closely linked to lifestyle and in particular to diet. For this reason, public health policies in European Union countries, in line with World Health Organization (WHO) recommendations, include in their priority measures actions aimed at promoting healthier food environments. One of these measures are policies for the reformulation of processed foods to reduce critical nutrients: salt, saturated fats, trans fats and added sugars. In Spain, as part of the NAOS Strategy, food reformulation measures have been implemented since 2008. Of all of them, the Plan de Colaboración para la Mejora de la Composición de Alimentos y Bebidas y otras Medidas 2020 stands out, which has led to a reduction in the content of salt, sugar, saturated and total fat in foods belonging to 57 subcategories marketed by the main food manufacturing and marketing companies from 2016 to 2021. Despite this, to date no population-based study has been conducted to test the impact of the measure on the diet of the Spanish population. The present article, by way of example, shows results of the theoretical estimation of total sugar intake in the pre-reformulation period (2016) and post-reformulation period (2024) based on the consumption of beverages in Spain. Data highlight that reformulation policies could have positive effects that need to be evaluated in representative studies of the Spanish population assessing the overall diet, in order to solidly confirm their positive effects on the population's diet.
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- 2024
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24. Efficacy and Safety of Habitual Consumption of a Food Supplement Containing Miraculin in Malnourished Cancer Patients: The CLINMIR Pilot Study.
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López-Plaza B, Álvarez-Mercado AI, Arcos-Castellanos L, Plaza-Diaz J, Ruiz-Ojeda FJ, Brandimonte-Hernández M, Feliú-Batlle J, Hummel T, Gil Á, and Palma-Milla S
- Subjects
- Humans, Male, Female, Pilot Projects, Middle Aged, Aged, Nutritional Status, Treatment Outcome, Taste Perception, Adult, Neoplasms complications, Neoplasms drug therapy, Malnutrition etiology, Malnutrition drug therapy, Dietary Supplements, Quality of Life
- Abstract
Taste disorders (TDs) are common among systemically treated cancer patients and negatively impact their nutritional status and quality of life. The novel food approved by the European Commission (EFSA), dried miracle berries (DMB), contains the natural taste-modifying protein miraculin. DMB, also available as a supplement, has emerged as a possible alternative treatment for TDs. The present study aimed to evaluate the efficacy and safety of habitual DMB consumption in malnourished cancer patients undergoing active treatment. An exploratory clinical trial was carried out in which 31 cancer patients were randomized into three arms [standard dose of DMB (150 mg DMB/tablet), high dose of DMB (300 mg DMB/tablet) or placebo (300 mg freeze-dried strawberry)] for three months. Patients consumed a DMB tablet or placebo daily before each main meal (breakfast, lunch, and dinner). Throughout the five main visits, electrochemical taste perception, nutritional status, dietary intake, quality of life and the fatty acid profile of erythrocytes were evaluated. Patients consuming a standard dose of DMB exhibited improved taste acuity over time (% change right/left side: -52.8 ± 38.5/-58.7 ± 69.2%) and salty taste perception (2.29 ± 1.25 vs. high dose: 2.17 ± 1.84 vs. placebo: 1.57 ± 1.51 points, p < 0.05). They also had higher energy intake ( p = 0.075) and covered better energy expenditure (107 ± 19%). The quality of life evaluated by symptom scales improved in patients receiving the standard dose of DMB (constipation, p = 0.048). The levels of arachidonic (13.1 ± 1.8; 14.0 ± 2.8, 12.0 ± 2.0%; p = 0.004) and docosahexaenoic (4.4 ± 1.7; 4.1 ± 1.0; 3.9 ± 1.6%; p = 0.014) acids in erythrocytes increased over time after DMB intake. The standard dose of DMB increased fat-free mass vs. placebo (47.4 ± 9.3 vs. 44.1 ± 4.7 kg, p = 0.007). Importantly, habitual patients with DMB did not experience any adverse events, and metabolic parameters remained stable and within normal ranges. In conclusion, habitual consumption of a standard 150 mg dose of DMB improves electrochemical food perception, nutritional status (energy intake, fat quantity and quality, fat-free mass), and quality of life in malnourished cancer patients receiving antineoplastic treatment. Additionally, DMB consumption appears to be safe, with no changes in major biochemical parameters associated with health status. Clinical trial registered (NCT05486260).
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- 2024
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25. [Nutrition in breast cancer genesis].
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López-Plaza B, Bermejo LM, Loria-Kohen V, and Fernández-Cruz E
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- Female, Humans, Vegetables, Meat, Fruit, Risk Factors, Diet, Nutritional Status, Breast Neoplasms epidemiology, Breast Neoplasms etiology, Breast Neoplasms prevention & control
- Abstract
Introduction: Breast cancer is the most prevalent tumor in women, ranking first in incidence and mortality in many countries. Although the causes of breast cancer are complex and multifactorial, nutritional factors and those related to nutritional status play an important role in the development of the disease. In this way, factors that increase breast cancer risk have been identified, such as weight gain, the amount of adipose tissue, waist circumference, alcohol consumption or the consumption of red meat and processed meat, while other factors have been identified that reduce the risk, such as eating fruits and vegetables. Nutritional factors or factors that depend on the state of nutrition are modifiable and preventable, so they must be considered when designing effective prevention programs.
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- 2023
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26. [Anorexia nervosa, microbiota and brain].
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Loria-Kohen V, Montiel Fernández N, López-Plaza B, and Aparicio A
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- Humans, Brain, Gastrointestinal Tract, Anorexia Nervosa therapy, Anorexia Nervosa psychology, Microbiota, Gastrointestinal Microbiome physiology
- Abstract
Introduction: Anorexia nervosa (AN) is a psychiatric disease with a high prevalence and comorbidities, characterized by a low response rate to treatment. It is considered as a multifactorial disease. In recent years, the focus has been placed on the presence of intestinal dysbiosis and its possible involvement as a causal factor as well as an alternative treatment. The objective of this work has been to review the current state of knowledge of alterations in the intestinal microbiota identified in patients with AN and the possibility of using probiotics as a therapeutic alternative. Significant changes in the diversity of species associated with weight loss have been described that could favor the perpetuation of the disorder, and that would explain many of the nutritional, gastrointestinal, psychological, and cognitive alterations present in these patients. The use of probiotics, still little studied in patients with AN, sheds some light on this matter to improve the treatment response, always hand in hand with conventional treatments.
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- 2023
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27. [Food sustainability: keys for the consumer, advantages and disadvantages].
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Bermejo LM, Trabado-Fernández A, Aparicio A, Lozano-Estevan MDC, and López-Plaza B
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- Female, Pregnancy, Adolescent, Humans, Child, Aged, Nutritive Value, Food Preferences, Nutritional Requirements, Food, Fortified, Diet, Food
- Abstract
Introduction: To meet the food and nutritional needs of a growing population and, at the same time, guarantee natural and productive resources, food systems must undergo changes in production models and consumption patterns, adopting more sustainable diets. The recommendations of different organizations and institutions are aimed at adopting a varied and balanced dietary pattern, with a greater predominance of plant-based food and a lower presence of animal food, to improve the state of health and well-being, while reducing the environmental impact. These types of diets have important health benefits, especially if diets are well planned and foods are properly combined. However, in some stages of life (schoolchildren, adolescents, elders) and in some special physiological situations (pregnancy, athletes), special attention should be paid to the increase of certain nutritional requirements that could compromise the health status if a correct dietary planning is not carried out. Therefore, well-designed strategies should be put in place to facilitate the transition to a sustainable diet, including nutrition education programs for consumers with specific instructions on the most appropriate food choices to increase the nutritional value of the diet. In addition, in specific physiological situations, where meeting nutritional requirements may be compromised, the consumption of fortified foods and/or supplementation could be considered.
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- 2023
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28. Effect of Regular Consumption of a Miraculin-Based Food Supplement on Taste Perception and Nutritional Status in Malnourished Cancer Patients: A Triple-Blind, Randomized, Placebo-Controlled Clinical Trial-CLINMIR Pilot Protocol.
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López-Plaza B, Gil Á, Menéndez-Rey A, Bensadon-Naeder L, Hummel T, Feliú-Batlle J, and Palma-Milla S
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- Humans, Taste Perception, Taste, Pilot Projects, Nutritional Status, Quality of Life, Fruit metabolism, Dietary Supplements, Randomized Controlled Trials as Topic, Neoplasms metabolism, Malnutrition etiology, Malnutrition metabolism
- Abstract
Taste disorders are common among cancer patients undergoing chemotherapy, with a prevalence ranging from 20% to 86%, persisting throughout treatment. This condition leads to reduced food consumption, increasing the risk of malnutrition. Malnutrition is associated not only with worse treatment efficacy and poor disease prognosis but also with reduced functional status and quality of life. The fruit of Synsepalum dulcificum (Daniell), commonly known as miracle berry or miracle fruit, contains miraculin, a taste-modifying protein with profound effects on taste perception. The CLINMIR Protocol is a triple-blind, randomized, placebo-controlled clinical trial designed to evaluate the regular consumption of a food supplement containing a miraculin-based novel food, dried miracle berry (DMB), on the taste perception (measured through electrogustometry) and nutritional status (evaluated through the GLIM Criteria) of malnourished cancer patients under active antineoplastic treatment. To this end, a pilot study was designed with 30 randomized patients divided into three study arms (150 mg DMB + 150 mg freeze-dried strawberries, 300 mg DMB, or placebo) for three months. Throughout the five main visits, an exhaustive assessment of different parameters susceptible to improvement through regular consumption of the miraculin-based food supplement will be conducted, including electrical and chemical taste perception, smell perception, nutritional and morphofunctional assessment, diet, quality of life, the fatty acid profile of erythrocytes, levels of inflammatory and cancer-associated cytokines, oxidative stress, antioxidant defense system, plasma metabolomics, and saliva and stool microbiota. The primary anticipated result is that malnourished cancer patients with taste distortion who consume the miraculin-based food supplement will report an improvement in food taste perception. This improvement translates into increased food intake, thereby ameliorating their nutritional status and mitigating associated risks. Additionally, the study aims to pinpoint the optimal dosage that provides maximal benefits. The protocol adheres to the SPIRIT 2013 Statement, which provides evidence-based recommendations and is widely endorsed as an international standard for trial protocols. The clinical trial protocol has been registered at the platform for Clinical Trials (NCT05486260).
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- 2023
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29. [Evaluation of the organoleptic characteristics of an oral nutritional supplement designed specifically for the cancer patient].
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Morato Martínez M, López-Plaza B, Arcos Castellanos L, Valero Pérez M, and Palma Milla S
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- Humans, Cross-Sectional Studies, Sensation, Dietary Supplements, Malnutrition, Neoplasms therapy
- Abstract
Introduction: Introduction: oral nutritional supplements (ONS) are nutritional therapies used to treat malnutrition in cancer patients, therefore, innovation in these treatments, from nutrients to sensory quality, is essential to ensure their consumption. Objectives: to evaluate the organoleptic characteristic of different prototypes of oral nutritional supplements specifically designed for cancer patients. Method: cross-sectional, randomized, double-blind pilot clinical study in patients with any type of cancer, with or without oncological treatment, who tasted five ONS prototypes with different flavors (brownie, tropical, pineapple, tomato and ham) and different sensory qualities in order to evaluate their organoleptic characteristics (color, smell, taste, residual taste, texture and density) through a specific questionnaire. Results: thirty patients aged 67.5 ± 11.2 years and body mass index (BMI) of 22.3 ± 3.52 kg/m2 were evaluated. The most prevalent tumors were head and neck (30 %), pancreas (20 %) and colon (17 %); 65 % of the patients had lost ≥ 10 % of their body weight in six months. The best rated supplements by the cancer population were those with brownie flavor (23.67 ± 3.91 points) and tropical (20.33 ± 3.37 points), while the least valued were tomato (16.33 ± 5.44 points) and ham flavor (13.97 ± 4.64 points). Conclusions: cancer patients value the organoleptic characteristics of ONS with sweet flavors, such as brownie, and fruity flavors, such as tropical, much more positively. Less appreciated by these patients are those with a salty taste, such as ham and tomato flavor.
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- 2023
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30. [Diet and lifestyle in cancer prevention].
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López-Plaza B, Loria-Kohen V, González-Rodríguez LG, and Fernández-Cruz E
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- Diet, Humans, Life Style, Risk Factors, Vegetables, Feeding Behavior, Neoplasms epidemiology, Neoplasms prevention & control
- Abstract
Introduction: European Union represents a tenth of the world population, however, it has a quarter of the cancer cases in the world. Without strong action, it is estimated that by 2035 cancer cases will increase by almost 25 %, making this disease the main cause of death. Therefore, the aim of this study is to know the diet and lifestyle guidelines associated to cancer prevention. A literature review has been carried out on the diet and lifestyle guidelines related to a reduction in cancer risk. Strategies to reduce cancer risk include maintaining a healthy weight, being physically active, consuming a diet rich in whole grains, fruits, non-starchy vegetables, and legumes, limit processed and fast food, limit consumption of red meat and eat little, if any, processed meats, drink mostly water and limit the consumption of sugar sweetened drinks, finally reduce, or do not consume alcohol. Prevention is an effective tool to reduce cancer risk. Adequate diet and healthy lifestyle habits can reduce cancer risk as well as other non-communicable diseases and can even have environmental benefits.
- Published
- 2022
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31. [Nutritional problems in celiac patients. Difficulties in achieving an adequate nutritional status].
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Jiménez Ortega AI, López-Plaza B, Ortega RM, Lozano Estevan MDC, and Martínez García RM
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- Diet, Gluten-Free, Glutens, Humans, Nutritional Status, Celiac Disease complications, Celiac Disease diagnosis, Celiac Disease therapy, Nutrition Disorders
- Abstract
Introduction: Celiac disease is the most common chronic intestinal disease. It affects approximately 1 % of the world population, affects all age groups and has symptoms both digestive and extra-digestive. The treatment of celiac disease is based on the strict withdrawal of gluten from the diet. This treatment supposes the improvement of symptoms and histology and the reduction of long-term comorbidities. People with celiac disease often follow diets that are far from the theoretical ideal, so they must be supervised and guided to achieve gluten-free diets that are also varied and balanced. In these patients it is important to avoid gluten consumption, but also to achieve an adequate supply of nutrients. However, their health problems, together with the limitations they must introduce in the diet make it more difficult to achieve a correct diet, so the group deserves special nutritional monitoring and surveillance.
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- 2022
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32. [Regular consumption of a functional broth enriched with FOS increases the levels of hormones related to satiety in healthy people. A randomized, controlled clinical trial].
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Arcos Castellanos L, López Plaza B, Morato Martínez M, Valero Pérez M, Palma Milla S, and Gómez Candela C
- Subjects
- Appetite, Blood Glucose, Cross-Over Studies, Ghrelin, Glucagon-Like Peptide 1, Humans, Insulin, Postprandial Period, Satiation, Leptin, Peptide YY
- Abstract
Introduction: Introduction: excess weight represents a public health problem due to its associated risk factors. A sedentary lifestyle, an inadequate diet or a decrease in the feeling of satiety are some of the causes. Objetives: to evaluate the satiating properties of the consumption of a functional Iberian broth enriched with phospho-fructooligosaccharides (FOS) in healthy people through the plasma concentration of hormones involved in appetite. Material and method: acute, crossover, randomized, double-blind and controlled nutritional clinical trial carried out in 18 randomized participants in two treatment sequences (functional broth (CF), composed of 5.6 g POS/100 g and control broth (CC), with 0.4 g of maltodextrin/100 g) with 14 days of washing in between. Satiety-related parameters (glucose, insulin, leptin, ghrelin, GLP-1, PYY) and visual analog scales (VAS) were measured. Results: the percentage of body fat decreased in those who took the CF (-0.15 ± 0.32 vs 0.09 ± 0.52) (p < 0.05). Leptin concentration was higher with CF (p < 0.001), which was shown at time points -30 (p < 0.001), 0 (p < 0.001), 30 (p = 0.026) and 120 (p = 0.049) when compared to CC. The areas under the curve (AUC) for GLP-1 (p = 0.0033) and PYY (p = 0.022) were higher for CF as compared to CC. Conclusions: consumption of an Iberian broth enriched with POS improves the plasma concentration of hormones involved in the control of satiety, and reduces the amount of body fat. This result could have beneficial effects for the prevention and treatment of overweight.
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- 2022
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33. Oral Supplement Containing Hydroxytyrosol and Punicalagin Improves Dyslipidemia in an Adult Population without Co-Adjuvant Treatment: A Randomized, Double-Blind, Controlled and Crossover Trial.
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Quirós-Fernández R, López-Plaza B, Bermejo LM, Palma Milla S, Zangara A, and Candela CG
- Subjects
- Adult, Cholesterol, HDL, Cholesterol, LDL, Cross-Over Studies, Double-Blind Method, Humans, Hydrolyzable Tannins, Phenylethyl Alcohol analogs & derivatives, Triglycerides, Dyslipidemias drug therapy
- Abstract
Hydroxytyrosol (HT) and punicalagin (PC) exert cardioprotective and antiatherosclerotic effects. This study evaluated the effect of an oral supplement containing HT and PC (SAx) on dyslipidemia in an adult population. A randomized, double-blind, controlled, crossover trial was conducted over a 20-week period. SAx significantly reduced the plasma levels of triglycerides (TG) in subjects with hypertriglyceridemia (≥150 mg/dL) (from 200.67 ± 51.38 to 155.33 ± 42.44 mg/dL; p < 0.05), while no such effects were observed in these subjects after the placebo. SAx also significantly decreased the plasma levels of low-density lipoprotein cholesterol (LDL-C) in subjects with high plasma levels of LDL-C (≥160 mg/dL) (from 179.13 ± 16.18 to 162.93 ± 27.05 mg/dL; p < 0.01), while no such positive effect was observed with the placebo. In addition, the placebo significantly reduced the plasma levels of high-density lipoprotein cholesterol (HDL-C) in the total population (from 64.49 ± 12.65 to 62.55 ± 11.57 mg/dL; p < 0.05), while SAx significantly increased the plasma levels of HDL-C in subjects with low plasma levels of HDL-C (<50 mg/dL) (from 44.25 ± 3.99 to 48.00 ± 7.27 mg/dL; p < 0.05). In conclusion, the supplement containing HT and PC exerted antiatherosclerotic and cardio-protective effects by considerably improving dyslipidemia in an adult population, without co-adjuvant treatment or adverse effects.
- Published
- 2022
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34. [Nutritional composition and nutritional claims of Canary Islands banana].
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Fernández Cruz E, López Plaza B, Santurino C, and Gómez Candela C
- Subjects
- Dietary Fiber analysis, Health Promotion standards, Health Promotion statistics & numerical data, Humans, Musa chemistry, Nutritive Value physiology, Spain, Musa metabolism, Nutrition Assessment
- Abstract
Introduction: Objectives: Canary Islands bananas represent the only native cultivar of Musa spp. present in Spanish territory. Since 2013, it has the Protected Geographical Indication label, which confers an additional value to this fruit. Bananas from the Canary Islands have certain organoleptic properties that make them stand out from among other commonly consumed Musa spp. However, to date, no studies have been reported including an extended nutritional composition of this product. Methods: the present work shows the main nutritional components of bananas from the Canary Islands as determined by different analytical techniques (mainly liquid chromatography, spectroscopy, spectrophotometry, and polarimetry) when at their best in terms of ripeness (grade 6). Moreover, potential nutrition claims relating to their composition were proposed using the current legislation. Results: the fruit's remarkable content, edible portion, in vitamin B6 (0.52 g/100 g), dietary fiber (2.22 g/100 g), potassium (419.9 mg/100 g), and vitamin C (12.35 mg/100 g) should be highlighted. Additionally, these components could appear on nutritional labeling as claims, according to current European regulations. Conclusions: a daily consumption of one Canary Islands banana contributes to the recommended dietary intake of vitamin B6, vitamin C, potassium, and dietary fiber. The high nutritional value of this fruit enhances its presence in the Mediterranean eating pattern, being remarkable as a local product with excellent nutritional properties.
- Published
- 2021
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35. Modulation of human intestinal microbiota in a clinical trial by consumption of a β-D-glucan-enriched extract obtained from Lentinula edodes.
- Author
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Morales D, Shetty SA, López-Plaza B, Gómez-Candela C, Smidt H, Marín FR, and Soler-Rivas C
- Subjects
- Adolescent, Adult, Aged, Animals, Cholesterol, Glucans, Humans, Middle Aged, Young Adult, Gastrointestinal Microbiome, Shiitake Mushrooms, beta-Glucans
- Abstract
Purpose: The aim of this study was to evaluate the hypocholesterolemic, immune- and microbiota-modulatory effect of a mushroom extract in hypercholesterolemic subjects., Methods: A randomized, controlled, double-blind, and parallel clinical trial was carried out with subjects from 18 to 65 years old (n = 52) with untreated mild hypercholesterolemia. Volunteers consumed a β-D-glucan-enriched (BGE) mixture (10.4 g/day) obtained from shiitake mushrooms (Lentinula edodes) ensuring a 3.5 g/day of fungal β-D-glucans or a placebo incorporated in three different commercial creams., Results: This mixture showed hypocholesterolemic activities in vitro and in animal studies. After eight weeks intervention, no significant differences in lipid- or cholesterol-related parameters were found compared to placebo subjects as well as before and after the BGE mixture administration. No inflammatory or immunomodulatory responses were noticed and no changes in IL-1β, IL-6, TNF-α or oxLDL were recorded. However, consumption of the BGE mixture was safe and managed to achieve the dietary fibre intake recommended as cardiovascular protective diet. Moreover, the BGE mixture modulated the colonic microbiota differently compared to placebo. Microbial community composition varied from before to after the intervention with several genera being positively or negatively correlated with some biomarkers related to cholesterol metabolism., Conclusion: These results suggested a relation between cholesterol metabolism, microbiota and BGE administration. Nevertheless, the precise significance of this differential modulation was not fully elucidated and requires further studies., (© 2021. Springer-Verlag GmbH, DE part of Springer Nature.)
- Published
- 2021
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36. A standardized, integral nutritional intervention and physical activity program reduces body weight in women newly diagnosed with breast cancer.
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Morato-Martínez M, Santurino C, López-Plaza B, Arcos-Castellanos L, Clavero-Fraile M, Valero-Pérez M, Palma Milla S, Valero M, and Gómez Candela C
- Subjects
- Female, Humans, Body Weight, Breast Neoplasms therapy, Exercise, Nutrition Therapy methods, Nutrition Therapy standards, Weight Loss
- Abstract
Introduction: Introduction: breast cancer is the most common invasive cancer among women in developed countries. At diagnosis, approximately 70 % of women are overweight, and the additional weight gain that can result from the ensuing treatments has been associated with cancer recurrence and progression. Objectives: the main objective was to compare the effect of only a nutritional intervention (CG) with a nutrition education program (nutritional intervention, nutrition education, and physical activity) (IG) for 1 year. Methods: a total of 65 women with breast cancer who had been evaluated at the Clinical Nutrition Department, La Paz University Hospital, Madrid, Spain were recruited into 2 groups: a control group (CG) and an intervention group (IG). Results: the IG showed a significant reduction in body weight (-1.87 ± 3.41 vs. 1.48 ± 2.01 kg, p < 0.05), BMI (-0.61 ± 1.40 vs. 0.65 ± 0.88 kg/m2, p < 0.05), total cholesterol (-32.92 ± 38.45 vs. -3.23 ± 39.73 mg/dl, p < 0.05), and low-density lipoprotein cholesterol (-35.29 ± 27.50 vs. 6.33 ± 40.70 mg/dl, p < 0.05). Both groups were shown to be more conscious of the importance of physical activity, with increased consumption of grains, fruits, oily fish, and dairy. Conclusions: dietary interventions and physical activity were shown to be important to achieving several physical and physiological benefits that could reduce some risk factors associated with breast cancer recurrence and progression.
- Published
- 2021
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37. [Comparison of the CONUT method with SGA and NSA for the prediction of complications, hospital stay, readmissions, and mortality].
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García-Vazquez N, Palma Milla S, López Plaza B, Valero-Pérez M, Morato-Martínez M, and Gómez Candela C
- Subjects
- Aged, Aged, 80 and over, Cholesterol blood, Female, Forecasting, Humans, Lymphocyte Count, Male, Malnutrition blood, Malnutrition mortality, Middle Aged, Prospective Studies, Retrospective Studies, Serum Albumin analysis, Length of Stay statistics & numerical data, Malnutrition complications, Malnutrition diagnosis, Mass Screening, Nutrition Assessment, Patient Readmission statistics & numerical data
- Abstract
Introduction: Introduction: disease-related malnutrition (DRM) is a specific type of malnutrition caused by the inflammatory response to the underlying disease. Its prevalence worldwide varies from 30 % to 50 %, being similar in Spanish hospitals. DRE is not commonly recognized but is usually misdiagnosed and generally not treated. It is associated with an increased risk of morbidity, mortality, and costs. Nutritional societies recommend that screening be performed within the first 24 to 48 hours after admission for the early detection of malnutrition. No screening tool is universally accepted. Objectives: to evaluate the predictive validity (hospital stay, complications, readmissions and mortality) of the CONUT method as compared to SGA and NSA. Material and method: a retrospective study included in a prospective observational study of 365 hospitalized patients from July to December 2012. Results: the most frequent admission services were Internal Medicine and Oncology (30.7 % and 29.3 %). Moderate and severe risk of malnutrition: CONUT, 42.2 % and 12.1 %, SGA 25.8 % and 10.1 %, and NSA 13.7 % and 14.5 %. Malnutrition evaluated using the CONUT method was significantly related to complications (p = 0.036), readmissions (p = 0.041) and mortality (p = 0.007). The ROC curves for mortality, for all the methods evaluated, showed that CONUT is the best tool. Conclusions: CONUT is an automatic detection tool that can be used as a first step in the diagnosis risk of malnutrition. CONUT offers the advantage of being a prognostic factor for complications, readmission, and mortality.
- Published
- 2020
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38. A Dairy Product to Reconstitute Enriched with Bioactive Nutrients Stops Bone Loss in High-Risk Menopausal Women without Pharmacological Treatment.
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Morato-Martínez M, López-Plaza B, Santurino C, Palma-Milla S, and Gómez-Candela C
- Subjects
- Biomarkers blood, Bone Density drug effects, Bone Resorption diet therapy, Calcium, Dietary administration & dosage, Collagen Type I blood, Dietary Supplements, Double-Blind Method, Female, Humans, Middle Aged, Osteoporosis, Postmenopausal etiology, Peptide Fragments blood, Peptides blood, Postmenopause drug effects, Procollagen blood, Treatment Outcome, Vitamin D administration & dosage, Bone Density Conservation Agents administration & dosage, Dairy Products, Functional Food, Osteoporosis, Postmenopausal prevention & control, Phytochemicals administration & dosage
- Abstract
Osteoporosis is a multifactorial disease characterized by the loss of bone mass and deterioration of the internal structure of the bone, increasing the risk of fractures, and is becoming an economic and social problem. The main treatment is pharmacological, however, the population demands other therapies, such as foods with nutrients beneficial to bone health. Seventy-eight healthy menopausal women at risk of osteoporosis or untreated osteopenia were recruited for a randomized, parallel, double-blind clinical trial with two intervention groups: one group consumed a serving a day of the experimental enriched product (experimental group (EG)) and the other group (control group (CG)) consumed the same product without enrichment. The main objective was to compare the effect of consuming a dairy preparation to reconstitute, similar to yogurt when prepared, enriched in calcium, vitamin D, vitamin K, vitamin C, zinc, magnesium, L-leucine and probiotic ( Lactobacillus plantarum 3547 ) on bone metabolism markers for 24 weeks. The EG showed a significantly increased bone mass compared to the CG (0.01 ± 0.03 vs. -0.01 ± 0.03 kg; p < 0.05). In addition, the EG maintained their bone mineral density (BMD) compared to the CG, whose BMD significantly decreased at the end of the study. For biochemical markers, the EG significantly increased the serum levels of the N-terminal propeptide of type I collagen (P1NP) bone formation marker (13.19 ± 25.17 vs. -4.21 ± 15.62 ng/mL; p < 0.05), and decreased the carbo-terminal telopeptide of type I collagen (CTx) bone resorption marker compared to the CG (-0.05 ± 0.19 vs. 0.04 ± 0.14 ng/mL; p < 0.05). On the other hand, the EG exhibited a significantly decreased systolic and diastolic blood pressure compared to the start of the study. Finally, the EG significantly increased their dietary calcium and vitamin D intake compared to the CG. In conclusion, the regular consumption of a dairy product to reconstitute enriched with bioactive nutrients improves bone health markers in menopausal women at risk of osteoporosis without pharmacological treatment.
- Published
- 2020
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39. Regular Consumption of Lipigo ® Promotes the Reduction of Body Weight and Improves the Rebound Effect of Obese People Undergo a Comprehensive Weight Loss Program.
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Valero-Pérez M, Bermejo LM, López-Plaza B, García MA, Palma-Milla S, and Gómez-Candela C
- Subjects
- Adult, Body Composition drug effects, Body Mass Index, Body Weight drug effects, Diet, Reducing methods, Double-Blind Method, Exercise physiology, Female, Humans, Male, Middle Aged, Obesity physiopathology, Treatment Outcome, Anti-Obesity Agents therapeutic use, Dietary Supplements, Obesity therapy, Weight Loss drug effects, Weight Reduction Programs methods
- Abstract
Obesity is a global public health problem., Objective: To evaluate the effect of the regular consumption of the product Lipigo
® on body weight and rebound effect on overweight/obese subjects undergoing a comprehensive weight loss program., Methods: A randomized, parallel, double-blind, placebo-controlled clinical trial was conducted with male and female subjects presenting a BMI 25-39.9 kg/m2 . All subjects underwent a comprehensive weight loss program (WLP) for 12 weeks, which included an individualized hypocaloric diet, physical activity recommendations, nutritional education seminars, and three times a day consumption of the product Lipigo® or Placebo. After-WLP, subjects continued the treatment for 9 months to assess rebound effect. Body weight (BW), BMI, and body composition were measured at the beginning and the end of the WLP, and in the follow-up., Results: A total of 120 subjects (85% women) 49.0 ± 9.5 years old and with a BW of 81.57 ± 13.26 kg (BMI 31.19 ± 3.44 kg/m2 ) were randomized and 73 subjects finished the study. At the end of the WLP, there was a tendency toward reduced BW (p = 0.093), BMI (p = 0.063), and WC (p = 0.059) in the treated group. However, subjects with obesity type 1 (OB1) from the treated group significantly reduced body weight (-5.27 ± 2.75 vs. -3.08 ± 1.73 kg; p = 0.017) and BMI (-1.99 ± 1.08 vs. -1.09 ± 0.55 kg/m2 ; p = 0.01) compared with placebo. They also presented a minor rebound effect after 9 months with product consumption (-4.19 ± 3.61 vs. -1.44 ± 2.51 kg; p = 0.026), minor BMI (-1.61 ± 1.43 vs. -0.52 ± 0.96 kg/m2 ; p = 0.025) and tended to have less fat-mass (-3.44 ± 2.46 vs. -1.44 ± 3.29 kg; p = 0.080) compared with placebo., Conclusions: The regular consumption of the product Lipigo® promotes the reduction of body weight and reduces the rebound effect of obese people after 52 weeks (12 months), mainly in obesity type 1, who undergo a comprehensive weight loss program., Competing Interests: M.A.G is a full-time employee of AB-Biotics SA, a company doing contract research work for DAMM SA. Other authors declare no conflicts of interest.- Published
- 2020
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40. Consumption of Goat Cheese Naturally Rich in Omega-3 and Conjugated Linoleic Acid Improves the Cardiovascular and Inflammatory Biomarkers of Overweight and Obese Subjects: A Randomized Controlled Trial.
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Santurino C, López-Plaza B, Fontecha J, Calvo MV, Bermejo LM, Gómez-Andrés D, and Gómez-Candela C
- Subjects
- Adolescent, Adult, Aged, Animals, Apolipoproteins B blood, Biomarkers blood, C-Reactive Protein analysis, Cardiovascular Diseases prevention & control, Double-Blind Method, Female, Heart Disease Risk Factors, Humans, Inflammation diagnosis, Inflammation etiology, Inflammation prevention & control, Male, Middle Aged, Peptide Fragments blood, Risk Factors, Young Adult, Cardiovascular Diseases diagnosis, Cardiovascular Diseases etiology, Cheese analysis, Cholesterol, HDL blood, Dietary Supplements, Fatty Acids, Omega-3 administration & dosage, Fatty Acids, Omega-3 analysis, Goats, Linoleic Acid administration & dosage, Linoleic Acid analysis, Nutritional Physiological Phenomena physiology, Obesity complications, Obesity drug therapy, Overweight complications, Overweight drug therapy
- Abstract
This study examines the value of a goat cheese naturally enriched in polyunsaturated fatty acids (PUFA) (n-3 PUFA and conjugated linolenic acid (CLA)) as means of improving cardiovascular and inflammatory health. Sixty-eight overweight and obese subjects (BMI ≥ 27 and <40 kg/m
2 ), with at least two risk factors for cardiovascular disease (CVD) in a lipid panel blood tests, participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed for 12 weeks: (1) 60 g/d control goat cheese and (2) 60 g/d goat cheese naturally enriched in n-3 PUFA and CLA. Diet and physical activity were assessed. Anthropometric and dual-energy X-ray absorptiometry (DXA) tests were performed. Blood samples were collected at the beginning and at the end of the study period. Changes in health status, lifestyle and dietary habits, and daily compliance were recorded. The consumption of a PUFA-enriched goat cheese significantly increased plasma high-density lipoprotein (HDL)-cholesterol, as well as in apolipoprotein B, and it significantly decreased high-sensitivity C-reactive protein concentrations compared to the control goat cheese ( p < 0.05). The significant improvement of the plasma lipid profile and inflammatory status of people with risk for CVD due to the consumption of PUFA-enriched cheese suggests a potential role of this dairy product as an alternative to develop high nutritional value food in a balanced diet comprising regular exercise.- Published
- 2020
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41. Strength plus Endurance Training and Individualized Diet Reduce Fat Mass in Overweight Subjects: A Randomized Clinical Trial.
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Benito PJ, López-Plaza B, Bermejo LM, Peinado AB, Cupeiro R, Butragueño J, Rojo-Tirado MA, González-Lamuño D, Gómez-Candela C, and On Behalf Of The Pronaf Study Group
- Subjects
- Adult, Body Composition, Female, Humans, Male, Diet, Reducing, Endurance Training, Obesity therapy, Overweight therapy, Resistance Training
- Abstract
Studies with overweight people are a priority in order to observe the effect of the timing of intervention on pre-obesity people. The aim was to compare different physical activity programs plus an individualized hypocaloric diet on body composition in overweight subjects. A randomized controlled clinical trial was carried out in overweight adults with no history of relevant illness. Primary outcome was total fat mass (TFM). Participants were allocated into four activity programs with equal intensity and volume of exercise for 22 weeks: strength training (S), endurance training (E), strength + endurance training (SE), and 'adhering to physical activity recommendations' (C). Participants followed a diet with 25% less energy (50%-55% carbohydrates, 30%-35% fat) measured by accelerometer. Variables were assessed at baseline and at the end of the intervention. Body composition was measured by dual-energy X-ray absorptiometry. One hundred nineteen from 205 subjects were randomized in the four exercise groups (S = 30/E = 30/SE = 30/C = 29) and 84 participants (36 men/48 women) ended the intervention (S = 19/E = 25/SE = 22/C = 18). At the end of the experiment, all groups except C increased their total physical activity (S = 1159 ± 1740; E = 1625 ± 1790; SE = 1699 ± 2516; C = 724 ± 1979 MET-min/week). Using an ANOVA-test, improvements were observed in body weight (S = -4.6 ± 4.5; E = -6.6 ± 4.6; SE = -8.5 ± 2.8; C = -6.1 ± 5.6 kg, p = 0.059) and TFM (S = -4.24 ± 2.02; E = -4.74 ± 2.96; SE = -6.74 ± 3.27; C = -3.94 ± 4.18%; p < 0.05). The main conclusion was that there were no adverse events. Strength and endurance training with a balanced, individualized hypocaloric diet was the most effective at reducing weight loss and fat mass in overweight subjects. Trial registration: NCT01116856.
- Published
- 2020
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42. The Effects of the Type of Exercise and Physical Activity on Eating Behavior and Body Composition in Overweight and Obese Subjects.
- Author
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Castro EA, Carraça EV, Cupeiro R, López-Plaza B, Teixeira PJ, González-Lamuño D, and Peinado AB
- Subjects
- Accelerometry, Adolescent, Adult, Body Mass Index, Diet, Reducing psychology, Energy Intake, Exercise psychology, Female, Humans, Male, Middle Aged, Motivation, Obesity physiopathology, Obesity psychology, Overweight physiopathology, Overweight psychology, Sex Factors, Young Adult, Body Composition, Feeding Behavior psychology, Obesity therapy, Overweight therapy, Weight Reduction Programs methods
- Abstract
The aim of this study was to examine whether a type of exercise favors better compliance with a prescribed diet, higher eating-related motivation, healthier diet composition or greater changes in body composition in overweight and obese subjects. One hundred and sixty-two (males n = 79), aged 18-50 years, were randomized into four intervention groups during 24 weeks: strength, endurance, combined strength + endurance and guideline-based physical activity; all in combination with a 25-30% caloric restriction diet. A food frequency questionnaire and a "3-day food and drink record" were applied pre- and post-intervention. Diet and exercise-related motivation levels were evaluated with a questionnaire developed for this study. Body composition was assessed by DXA and habitual physical activity was measured by accelerometry. Body weight, body mass index (BMI) and body fat percentage decreased and lean body mass increased after the intervention, without differences by groups. No interactions were observed between intervention groups and time; all showing a decreased in energy intake ( p < 0.001). Carbohydrate and protein intakes increased, and fat intake decreased from pre- to post-intervention without significant interactions with intervention groups, BMI category or gender ( p < 0.001). Diet-related motivation showed a tendency to increase from pre- to post-intervention (70.0 ± 0.5 vs 71.0 ± 0.6, p = 0.053), without significant interactions with intervention groups, BMI or gender. Regarding motivation for exercise, gender x time interactions were observed ( F
(1,146) = 7.452, p = 0.007): Women increased their motivation after the intervention (pre: 17.6 ± 0.3, post: 18.2 ± 0.3), while men maintained it. These findings suggest that there are no substantial effects of exercise type on energy intake, macronutrient selection or body composition changes. After a six-month weight loss program, individuals did not reduce their motivation related to diet or exercise, especially women. Individuals who initiate a long-term exercise program do not increase their energy intake in a compensatory fashion, if diet advices are included.- Published
- 2020
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43. Milk and Dairy Product Consumption and Bladder Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies.
- Author
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Bermejo LM, López-Plaza B, Santurino C, Cavero-Redondo I, and Gómez-Candela C
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Cultured Milk Products, Dietary Fats administration & dosage, Female, Humans, Male, Middle Aged, Milk, Young Adult, Dairy Products, Diet, Feeding Behavior, Urinary Bladder Neoplasms etiology, Urinary Bladder Neoplasms prevention & control
- Abstract
Some studies have reported that milk and dairy product consumption reduces bladder cancer incidence, whereas others have reported null or opposite findings. This meta-analysis of 26 cohort and case-control studies has been conducted to pool the risk of the association between milk and dairy products and bladder cancer. A systematic search in MEDLINE, EMBASE, and the Web of Science (from inception to 30 April 2018) was conducted. Random-effects models were used to compute pooled estimates of RR for high or medium compared with low consumption of milk and dairy. Sensitivity analyses were conducted. Subgroup analyses were performed based on type of dairy, gender, geographic location, and type of study design. Random-effects meta-regression was used to evaluate other confounding factors. Overall, medium compared with low consumption was associated with lower pooled risk of bladder cancer for total dairy products (RR = 0.90; 95% CI: 0.81, 0.98), milk (RR = 0.90; 95% CI: 0.82, 0.98), and fermented dairy products (RR = 0.87; 95% CI: 0.79, 0.96). The inverse association for milk consumption was stronger in Asians (RR = 0.79; 95% CI: 0.59, 0.98) and in cohort design studies (RR = 0.85; 95% CI: 0.71, 0.99). Moreover, high compared with low consumption was significantly associated with a lower pooled risk for milk (RR = 0.89; 95% CI: 0.81, 0.98) and fermented dairy products (RR = 0.78; 95% CI: 0.61, 0.94). However, high compared with low consumption of whole milk was significantly associated with a higher risk (RR = 1.21; 95% CI: 1.04, 1.38). The statistical heterogeneity was considerable. In conclusion, the present meta-analysis suggests a decreased risk of bladder cancer associated with medium consumption of total dairy products and with medium and high consumption of milk and fermented dairy products. An increased risk of bladder cancer was observed with high consumption of whole milk. Interpretations of the results should be made with caution. This review was registered at www.crd.york.ac.uk/prospero as CRD42018097020., (Copyright © American Society for Nutrition 2019.)
- Published
- 2019
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44. Milk and Dairy Product Consumption and Prostate Cancer Risk and Mortality: An Overview of Systematic Reviews and Meta-analyses.
- Author
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López-Plaza B, Bermejo LM, Santurino C, Cavero-Redondo I, Álvarez-Bueno C, and Gómez-Candela C
- Subjects
- Animals, Humans, Male, Milk, Prostatic Neoplasms mortality, Dairy Products, Diet, Feeding Behavior, Prostatic Neoplasms etiology
- Abstract
Milk and dairy product consumption has been associated with an increase in prostate cancer risk; however, discrepancies have been observed in the literature. This first overview of systematic reviews and meta-analyses was carried out with the main objective of compiling and discussing the evidence generated to date related to milk and dairy product consumption and prostate cancer risk and mortality. A systematic search in MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and the Web of Science (from inception to 30 April 2018) was conducted. The inclusion criteria were as follows: adult men, meta-analyses of longitudinal studies, dairy product consumption, and risk of prostate cancer or related outcomes. The AMSTAR2 checklist was used to evaluate methodological quality. The synthesis methods included dairy product exposure (high compared with low consumption or dose-response), dairy product type (total dairy products, milk, cheese, yogurt, and others), and prostate cancer outcomes (total, nonadvanced, and advanced prostate cancer and mortality) displayed in forest plots. Six meta-analyses were identified. These studies reported on the analysis of the 2 to 32 cohorts (up to 848,395 subjects/38,107 cases; 4-28 y of follow-up) and 2 case-control meta-analyses (12,435 subjects). The meta-analysis quality was valued as mostly "good" according to the AMSTAR2 criteria. All RRs of high compared with low consumption (dose-response) for total prostate cancer ranged from 1.68 to 1.09 (1.07 per 400 g/d) for total dairy products, 1.50 to 0.92 (1.06 to 0.98 per 200 g/d) for milk (whole, low-fat, and skim milk considered separately), and 1.18 to 0.74 (1.10 per 50 g/d) for cheese. RRs have decreased since the first meta-analysis. Statistical heterogeneity generates uncertainty in the observed results (up to I2 = 77.1%). In conclusion, although there are some data indicating that higher consumption of dairy products could increase the risk of prostate cancer, the evidence is not consistent. This review was registered with PROSPERO as CRD42018094737., (Copyright © American Society for Nutrition 2019.)
- Published
- 2019
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45. Supplementation with Hydroxytyrosol and Punicalagin Improves Early Atherosclerosis Markers Involved in the Asymptomatic Phase of Atherosclerosis in the Adult Population: A Randomized, Placebo-Controlled, Crossover Trial.
- Author
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Quirós-Fernández R, López-Plaza B, Bermejo LM, Palma-Milla S, and Gómez-Candela C
- Subjects
- Aged, Atherosclerosis etiology, Atherosclerosis physiopathology, Biomarkers metabolism, Blood Pressure physiology, Cross-Over Studies, Double-Blind Method, Female, Humans, Hypertension complications, Hypertension physiopathology, Hypertension therapy, Male, Middle Aged, Phenylethyl Alcohol administration & dosage, Prehypertension complications, Prehypertension physiopathology, Prehypertension therapy, Treatment Outcome, Atherosclerosis therapy, Cardiotonic Agents administration & dosage, Dietary Supplements, Hydrolyzable Tannins administration & dosage, Phenylethyl Alcohol analogs & derivatives
- Abstract
Hydroxytyrosol (HT) and Punicalagin (PC) exert cardioprotective and anti-atherosclerotic effects. This study evaluates the effect of oral supplementation with HT and PC (SAx) on early atherosclerosis markers in middle-aged, seemingly healthy adults. A randomized, double-blinded, placebo-controlled, crossover trial was performed for 20 weeks. There were two treatment sequences (Placebo/SAx, n = 41; SAx/Placebo, n = 43) for which the intervention periods (Placebo and SAx) were 8 weeks long, followed by a 4-week wash out period. The supplement was composed of 9.9 mg of HT and 195 mg of PC, and the placebo was composed of maltodextrin. SAx increased endothelial function (Flow-mediated dilatation [FMD]: 2.36%; p < 0.001) in the endothelial dysfunction subgroup compared to the placebo (2.36 ± 3.9 vs. 0.76 ± 3.5%, p < 0.05). SAx also reduced oxLDL by -28.74 ng/mL ( p < 0.05) in subjects with higher levels of oxLDL, which was an improvement compared with the placebo (-28.74 ± 40.2 vs. 25.64 ± 93.8 ng/mL, p < 0.001). The prehypertension and hypertension subgroups exhibited decreased systolic (-15.75 ± 9.9 mmHg; p < 0.001) and diastolic (-6.36 ± 8.7 mmHg; p < 0.001) blood pressure after SAx consumption. Moreover, the systolic prehypertension and hypertension subgroups presented significant differences in systolic blood pressure compared to the placebo (-15.75 ± 9.9 vs. -2.67 ± 12.0 mmHg, p < 0.05). In conclusion, the supplement exerted anti-atherosclerotic effects by improving endothelial function, blood pressure, and levels of circulating oxLDL, especially for persons in whom these parameters were altered.
- Published
- 2019
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46. [Bioactive food compounds as adjuvants to breast cancer treatment: vitamin D and omega-3].
- Author
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Bermejo LM, Gómez-Candela C, Dahdouh S, and López-Plaza B
- Subjects
- Combined Modality Therapy, Female, Humans, Quality of Life, Breast Neoplasms drug therapy, Chemotherapy, Adjuvant methods, Fatty Acids, Omega-3 therapeutic use, Vitamin D therapeutic use, Vitamins therapeutic use
- Abstract
Introduction: breast cancer (BC) is the most commonly diagnosed tumor in women and it continues to be the leading cause of cancer death in women. Quality of life decreases significantly during treatment and in the survivors. There is growing evidence linking the intake of certain foods, or their bioactive compounds, with better prognosis of the disease or improvements in physiological parameters that can increase BC patients' quality of life. But there are hardly any reviews to clarify the scientific evidence., Objectives: gathering and summarizing the available evidence on the effectiveness of the dietary compounds use as coadjuvants for BC treatment., Method: literature search using Pubmed to identify and analyze bioactive compounds as coadjvants for BC treatment., Results: all tested compounds showed antitumor effects in vitro. Vvitamin D decrease risk of bone fracture, and marine lipids may reduce bone resorption and inflammation., Conclusion: there are bioactive compounds with potential to improve the quality of life of women with BC. Vitamin D a marine lipids provide a solid quality scientific evidence. Despite this, more controlled clinical trials are required to establish a direct link between the use of these compounds and the tumor progression or patient survival.
- Published
- 2018
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47. Nutritional Composition Assessment of 3000 Individualized Parenteral Nutrition Bags in a Tertiary Referral Hospital: Current Prescribing Patterns.
- Author
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Pelegrina-Cortés B, Bermejo LM, López-Plaza B, Palma-Milla S, García-Vázquez N, and Gómez-Candela C
- Subjects
- Dietary Carbohydrates analysis, Dietary Fats analysis, Dietary Proteins analysis, Humans, Nitrogen analysis, Retrospective Studies, Spain, Specialization trends, Nutrition Assessment, Nutritive Value, Parenteral Nutrition, Parenteral Nutrition Solutions analysis, Practice Patterns, Physicians' trends, Prescriptions, Referral and Consultation trends, Tertiary Care Centers trends
- Abstract
Individualized parenteral nutrition is the most specialized type of nutritional support in the hospital setting. The composition and prescribing patterns for parenteral nutrition have evolved due to new emerging scientific evidence. In the last few years, there has been a tendency to increase the nitrogen and lipid content and decrease the carbohydrate content. To assess the prescribing pattern in a tertiary referral hospital in Spain, the nutritional composition of individualized parenteral nutrition was evaluated retrospectively from January to December of 2016. A total of 3029 parenteral nutrition units were analysed, corresponding to 257 hospitalized adult patients. Medical specialists in General Surgery and Haematology were the most common petitioners. The three most frequently prescribed parenteral nutrition formulae contained 13.4 (28.8%), 15.7 (19.54%) and 17.9 (17.79%) g of nitrogen. The quantity of carbohydrates and lipids showed a mean non-protein calories-to-nitrogen ratio of approximately 78:1 and a carbohydrate-to-lipid ratio that was near 50:50 in most cases. These results suggest a trend towards the administration of parenteral nutrition with a high content of nitrogen and smaller proportion of the non-protein components.
- Published
- 2018
- Full Text
- View/download PDF
48. [A global vision of adverse reactions to foods: food allergy and food intolerance].
- Author
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Ruiz Sánchez JG, Palma Milla S, Pelegrina Cortés B, López Plaza B, Bermejo López LM, and Gómez-Candela C
- Subjects
- Adult, Age Factors, Child, Child, Preschool, Food Additives adverse effects, Food Hypersensitivity immunology, Fruit adverse effects, Humans, Lactose Intolerance epidemiology, Food adverse effects, Food Hypersensitivity epidemiology, Food Intolerance epidemiology
- Abstract
Over the last years, there has been an increase in adverse food reactions, probably associated with life style changes in the past decades. An adverse food reaction is any clinically abnormal response that can be attributed to ingestion, contact or inhalation of a food, its derivatives or an additive contained in it. They can be classified as food allergy or intolerance. Food allergies are usually immune-mediated, associated with IgE. Adverse reactions to food have a large clinical and social repercussion, which can be fatal in some cases and impair the quality of life of patients. This implies directly the services of collective catering and food manufacturing, which is why a legislature and regulations were implemented for its correct management. The most allergenic foods change according to the age group; being the egg the most frequent in children under 5 years, and fresh fruits in the older than 5 years. The most frequent clinical manifestations are cutaneous-mucous type. Food intolerances may be due to a pharmacological, metabolic, mixed or idiosyncratic mechanism. Clinical manifestations are usually dose dependent. The most common and known food intolerance is lactose, which is a metabolic type. The main treatment of both types of adverse reaction to foods is avoidance of the causal food of the reaction.
- Published
- 2018
- Full Text
- View/download PDF
49. New, Immunomodulatory, Oral Nutrition Formula for Use Prior to Surgery in Patients With Head and Neck Cancer: An Exploratory Study.
- Author
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Palma-Milla S, López-Plaza B, Santamaría B, de Arriba-Sánchez Á, Bermejo LM, and Gómez-Candela C
- Subjects
- Administration, Oral, Female, Head and Neck Neoplasms immunology, Humans, Length of Stay statistics & numerical data, Male, Middle Aged, Postoperative Complications immunology, Single-Blind Method, Treatment Outcome, Enteral Nutrition methods, Head and Neck Neoplasms surgery, Immunomodulation immunology, Postoperative Complications prevention & control, Preoperative Care methods
- Abstract
Background: The perioperative use of immunomodulatory nutrition formulas in patients with head and neck cancer reduces the number of postoperative infections and the length of hospital stay., Objective: An exploratory, randomized, controlled, blind, clinical trial was designed to examine the effect of the preoperative consumption of a new, immunomodulatory, oral nutrition formula in patients with head and neck cancer., Methods: Thirty-eight patients were randomized to receive either 400 mL/d of either the new immunomodulatory formula (IF) or that commonly used in clinical practice (CF) over 10 days prior to surgery. Thirty-three patients completed the study. Compliance, tolerance, the length of hospital stay, the incidence of infections and noninfectious complications before discharge, and the same up to 15 and 30 days after discharge were recorded., Results: The percentage of patients who developed infections before discharge was significantly lower in the IF than in the CF group (P = .013), as was the number of infections/100 patients/d (P = .035). The length of hospital stay was significantly shorter in the IF group (P = .001). Both formulas were safe and well tolerated. No other differences were detected. These results suggest preoperative consumption of the new formula to be beneficial for patients with neck and head cancer. Further trials are needed to confirm these results and to test the efficacy of the formula in patients with other conditions., Conclusion: The new formula can be safely prescribed as part of the preoperative treatment of patients with head and neck cancer and might reduce the problem of postoperative infection., (© 2016 American Society for Parenteral and Enteral Nutrition.)
- Published
- 2018
- Full Text
- View/download PDF
50. Nutrition and immune system disorders
- Author
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López Plaza B and Bermejo López LM
- Subjects
- Humans, Immune System, Nutrition Disorders immunology, Nutritional Status, Vitamins, Immune System Diseases therapy, Nutritional Physiological Phenomena
- Abstract
Introduction: Energy and nutrients obtained through food play an important role in the development and preservation of the immune system therefore any nutritional imbalance affects its competence and integrity., Objectives: Knowing the nutritional approach on different disorders of the immune system., Methods: A review has been carried out on the most prevalent immunological disorders in developed countries, the nutritional characteristics to which they are associated and their nutritional approach., Results: Nutritional treatment for immune disorders has focused in recent years on the role of PUFA-ω3 and vitamin D. Maintaining body weight, preventing malnutrition and protein catabolism are key strategies for nutritional treatment. This should be adapted to each disease stage because it is a dynamic process., Conclusions: Nutritional treatment for immunological disorders, especially in autoimmune diseases, is not always clear because they present acute and remission states. Anorexia is one of the most characteristic symptoms derived mainly from pharmacological treatment and inflammatory processes. Diet should be dense in nutrients that prevent deterioration.Nutritional treatment of immunological disorders should aim to maintain an optimal state of nutrition during symptomatic periods, prevent their deterioration during acute episodes and improve during stable periods free of symptoms.
- Published
- 2017
- Full Text
- View/download PDF
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