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3. Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target

Author

Dobaño-López, Cèlia, Valero, Juan García, Araujo-Ayala, Ferran, Nadeu, Ferran, Gava, Fabien, Faria, Carla, Norlund, Marine, Morin, Renaud, Bernes-Lasserre, Pascale, Arenas, Fabian, Grau, Marta, López, Cristina, López-Oreja, Irene, Serrat, Neus, Martínez-Farran, Ares, Hernández, Lluís, Playa-Albinyana, Heribert, Giménez, Rubén, Beà, Silvia, Campo, Elías, Lagarde, Jean-Michel, López-Guillermo, Armando, Magnano, Laura, Colomer, Dolors, Bezombes, Christine, and Pérez-Galán, Patricia

Published
2024
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4. Long-term surveillance of the feline leukemia virus in the endangered Iberian lynx (Lynx pardinus) in Andalusia, Spain (2008–2021)

Author

Nájera, Fernando, López, Guillermo, del Rey-Wamba, Tere, Malik, Rimsha A., Garrote, Germán, López-Parra, Marcos, Fernández-Pena, Leonardo, García-Tardío, Maribel, Arenas-Rojas, Rafael, Simón, Miguel A., Zorrilla, Irene, Fernández, Isabel, Alcaide, Eva M., Ruiz, Carmen, Revuelta, Luis, Salcedo, Javier, Hofmann-Lehmann, Regina, and Meli, Marina L.

Published
2024
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5. Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma

Author

Locke, Frederick L., Filosto, Simone, Chou, Justin, Vardhanabhuti, Saran, Perbost, Regis, Dreger, Peter, Hill, Brian T., Lee, Catherine, Zinzani, Pier L., Kröger, Nicolaus, López-Guillermo, Armando, Greinix, Hildegard, Zhang, Wangshu, Tiwari, Gayatri, Budka, Justin, Marincola, Francesco M., To, Christina, Mattie, Mike, Schupp, Marco, Cheng, Paul, Bot, Adrian, Shen, Rhine, Bedognetti, Davide, Miao, Harry, and Galon, Jérôme

Published
2024
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7. Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target

Author

Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors Colomer, Christine Bezombes, and Patricia Pérez-Galán

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome. Here we present the first FL-Patient Derived Lymphoma Spheroid (FL-PDLS), including fundamental immune actors and features of TME in FL lymph nodes (LNs). FL-PDLS is organized in disc-shaped 3D structures composed of proliferating B and T cells, together with macrophages with an intermediate M1/M2 phenotype. FL-PDLS recapitulates the most relevant B-cell transcriptional pathways present in FL-LN (proliferation, epigenetic regulation, mTOR, adaptive immune system, among others). The T cell compartment in the FL-PDLS preserves CD4 subsets (follicular helper, regulatory, and follicular regulatory), also encompassing the spectrum of activation/exhaustion phenotypes in CD4 and CD8 populations. Moreover, this system is suitable for chemo and immunotherapy testing, recapitulating results obtained in the clinic. FL-PDLS allowed uncovering that soluble galectin-9 limits rituximab, rituximab, plus nivolumab/TIM-3 antitumoral activities. Blocking galectin-9 improves rituximab efficacy, highlighting galectin-9 as a novel immunotherapeutic target in FL. In conclusion, FL-PDLS maintains the crosstalk between malignant B cells and the immune LN-TME and constitutes a robust and multiplexed pre-clinical tool to perform drug screening in a patient-derived system, advancing toward personalized therapeutic approaches.

Published
2024
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9. Modelling of saturated external MHD instabilities in tokamaks: a comparison of 3D free boundary equilibria and nonlinear stability calculations

Author

Ramasamy, Rohan, Ramirez, Guillermo Bustos, Hoelzl, Matthias, Graves, Jonathan, López, Guillermo Suárez, Lackner, Karl, Günter, Sibylle, and team, the JOREK

Subjects
Physics - Plasma Physics
Abstract

3D free boundary equilibrium computations have recently been used to model external kinks and edge harmonic oscillations (EHOs), comparing with linear MHD stability codes, and nonlinear analytic theory [Kleiner et al, PPCF 61 084005 (2019)]. In this study, results of the VMEC equilibrium code are compared further with nonlinear reduced MHD simulations, using the JOREK code. The purpose of this investigation is to understand the extent to which the modelling approaches agree, and identify the important physical effects which can modify the dynamics. For the simulated external kink, which is dominated by a single toroidal harmonic, good agreement is found when a large Lundquist number is used in the JOREK simulation, such that resistive effects are sub-dominant. Modelling EHOs where multiple toroidal harmonics are linearly unstable, the saturated perturbation observed can differ in the dominant toroidal harmonic. On the ideal timescale, a n=2 EHO is observed in JOREK, while the saturated perturbation predicted by VMEC is a n=1 mode. Extending simulations into timescales where resistive effects can play a role, similar n=1 perturbations can be found. The coupling of different linearly unstable toroidal harmonics in the JOREK simulation broadens the magnetic energy spectrum and ergodises the plasma edge region, resulting in a more localised pressure perturbation. These effects are not observed in VMEC, because closed magnetic flux surfaces are enforced. Despite the sensitivity of JOREK results on the assumed resistivity, saturated states can be found using both approaches that are in reasonable agreement, even for this more advanced case., Comment: Submitted to Physics of Plasmas, with revisions from review process included

Published
2022
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11. Impacto de la guardia de cardiología en el tratamiento de reperfusión de los pacientes con IAMCEST en un centro de segundo nivel

Author

Santás Álvarez, Melisa, Bayón Lorenzo, Jeremías, Aldama López, Guillermo, Paredes Galán, Emilio, Abellás Sequeiros, Rosa Alba, Ocaranza Sánchez, Raymundo, Franco Gutiérrez, Raúl, Pereira López, Eva María, López López, Andrea, Prada Delgado, Óscar, Méndez Eirín, Elizabet, Pérez Cebey, Lucía, Iglesias Río, Enrique, Rodríguez Fernández, José Ángel, Vázquez Rodríguez, José Manuel, and González-Juanatey, Carlos

Published
2024
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12. MALAT1 expression is associated with aggressive behavior in indolent B-cell neoplasms

Author

Elena María Fernández-Garnacho, Ferran Nadeu, Silvia Martín, Pablo Mozas, Andrea Rivero, Julio Delgado, Eva Giné, Armando López-Guillermo, Martí Duran-Ferrer, Itziar Salaverria, Cristina López, Sílvia Beà, Santiago Demajo, Pedro Jares, Xose S. Puente, José Ignacio Martín-Subero, Elías Campo, and Lluís Hernández

Subjects
Medicine, Science
Abstract

Abstract MALAT1 long non-coding RNA has oncogenic roles but has been poorly studied in indolent B-cell neoplasms. Here, MALAT1 expression was analyzed using RNA-seq, microarrays or qRT-PCR in primary samples from clinico-biological subtypes of chronic lymphocytic leukemia (CLL, n = 266), paired Richter transformation (RT, n = 6) and follicular lymphoma (FL, n = 61). In peripheral blood (PB) CLL samples, high MALAT1 expression was associated with a significantly shorter time to treatment independently from other known prognostic factors. Coding genes expressed in association with MALAT1 in CLL were predominantly related to oncogenic pathways stimulated in the lymph node (LN) microenvironment. In RT paired samples, MALAT1 levels were lower, concordant with their acquired increased independency of external signals. Moreover, MALAT1 levels in paired PB/LN CLLs were similar, suggesting that the prognostic value of MALAT1 expression in PB is mirroring expression differences already present in LN. Similarly, high MALAT1 expression in FL predicted for a shorter progression-free survival, in association with expression pathways promoting FL pathogenesis. In summary, MALAT1 expression is related to pathophysiology and more aggressive clinical behavior of indolent B-cell neoplasms. Particularly in CLL, its levels could be a surrogate marker of the microenvironment stimulation and may contribute to refine the clinical management of these patients.

Published
2023
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15. Born to be wild: Captive-born and wild Iberian lynx (Lynx pardinus) reveal space-use similarities when reintroduced for species conservation concerns

Author

Cisneros-Araujo, Pablo, Garrote, German, Corradini, Andrea, Farhadinia, Mohammad S., Robira, Benjamin, López, Guillermo, Fernández, Leonardo, López-Parra, Marcos, García-Tardío, Maribel, Arenas-Rojas, Rafael, del Rey, Teresa, Salcedo, Javier, Sarmento, Pedro, Sánchez, Juan Francisco, Palacios, María Jesús, García-Viñás, Juan Ignacio, Damiani, Maria Luisa, Hachem, Fatima, Gastón, Aitor, and Cagnacci, Francesca

Published
2024
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24. Unraveling the genetics of transformed splenic marginal zone lymphoma

Author

Grau, Marta, López, Cristina, Navarro, Alba, Frigola, Gerard, Nadeu, Ferran, Clot, Guillem, Bastidas-Mora, Gabriela, Alcoceba, Miguel, Baptista, Maria Joao, Blanes, Margarita, Colomer, Dolors, Costa, Dolors, Domingo-Domènech, Eva, Enjuanes, Anna, Escoda, Lourdes, Forcada, Pilar, Giné, Eva, Lopez-Guerra, Mónica, Ramón, Olga, Rivas-Delgado, Alfredo, Vicente Folch, Laura, Wotherspoon, Andrew, Climent, Fina, Campo, Elias, López-Guillermo, Armando, Matutes, Estella, and Beà, Sílvia

Published
2023
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26. SARS-CoV-2: Air pollution highly correlated to the increase in mortality. The case of Guadalajara, Jalisco, México

Author

Torres-Anguiano, Elizabeth, Sánchez-López, Itzel, Garduno-Robles, Angeles, Rivas-Carrillo, Jorge David, Rivera-León, Edgar Alfonso, Sánchez-Enríquez, Sergio, Ornelas-Hernández, Luis Fernando, Zazueta León-Quintero, Fernando, Salazar León-Quintero, Eduardo Narciso, Juárez-López, Guillermo Enrique, Sánchez-Zubieta, Fernando Antonio, Ochoa-Bru, Mariana, and Zepeda-Moreno, Abraham

Published
2023
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29. Detection of early seeding of Richter transformation in chronic lymphocytic leukemia

Author

Nadeu, Ferran, Royo, Romina, Massoni-Badosa, Ramon, Playa-Albinyana, Heribert, Garcia-Torre, Beatriz, Duran-Ferrer, Martí, Dawson, Kevin J., Kulis, Marta, Diaz-Navarro, Ander, Villamor, Neus, Melero, Juan L., Chapaprieta, Vicente, Dueso-Barroso, Ana, Delgado, Julio, Moia, Riccardo, Ruiz-Gil, Sara, Marchese, Domenica, Giró, Ariadna, Verdaguer-Dot, Núria, Romo, Mónica, Clot, Guillem, Rozman, Maria, Frigola, Gerard, Rivas-Delgado, Alfredo, Baumann, Tycho, Alcoceba, Miguel, González, Marcos, Climent, Fina, Abrisqueta, Pau, Castellví, Josep, Bosch, Francesc, Aymerich, Marta, Enjuanes, Anna, Ruiz-Gaspà, Sílvia, López-Guillermo, Armando, Jares, Pedro, Beà, Sílvia, Capella-Gutierrez, Salvador, Gelpí, Josep Ll., López-Bigas, Núria, Torrents, David, Campbell, Peter J., Gut, Ivo, Rossi, Davide, Gaidano, Gianluca, Puente, Xose S., Garcia-Roves, Pablo M., Colomer, Dolors, Heyn, Holger, Maura, Francesco, Martín-Subero, José I., and Campo, Elías

Published
2022
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30. Molecular Pathogenesis of Follicular Lymphoma: From Genetics to Clinical Practice

Author

Cristina López, Pablo Mozas, Armando López-Guillermo, and Sílvia Beà

Subjects
follicular lymphoma, BCL2 rearrangement, genetic alterations, histological transformation, tumor microenvironment, targeted therapies, Medicine
Abstract

Follicular lymphoma (FL), a generally indolent disease that derives from germinal center (GC) B cells, represents around 20–25% of all new lymphomas diagnosed in Western countries. The characteristic t(14;18)(q32;q21) translocation that places the BCL2 oncogene under control of the immunoglobulin heavy-chain enhancer occurs in pro- or pre-B cells. However, additional secondary alterations are required for the development of overt FL, which mainly affects genes involved in epigenetic and transcriptional regulation, signaling and B cell differentiation, the BCR/NF-κB pathway, and proliferation/apoptosis. On the other hand, new insights into the FL pathogenesis suggest that FL lacking the BCL2 translocation might be a distinct biological entity with genomic features different from the classical FL. Although FL is considered an indolent disease, around 10–20% of cases eventually transform to an aggressive lymphoma, usually a diffuse large B cell lymphoma, generally by a divergent evolution process from a common altered precursor cell acquiring genomic alterations involved in the cell cycle and DNA damage responses. Importantly, FL tumor cells require interaction with the microenvironment, which sustains cell survival and proliferation. Although the use of rituximab has improved the outlook of most FL patients, further genomic studies are needed to identify those of high risk who can benefit from innovative therapies. This review provides an updated synopsis of FL, including the molecular and cellular pathogenesis, key events of transformation, and targeted treatments.

Published
2022
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32. TOP-350-YI DNA differential methylation as a potential drug-induced liver injury biomarker and genome-wide DNA methylation functional analysis

Author

De los Santos Fernández, Romina, primary, Villanueva, Marina, additional, Alvarez-Alvarez, Ismael, additional, Niu, Hao, additional, Stephens, Camilla, additional, Jiménez, Andrés González, additional, López, Guillermo Paz, additional, Bandera, Jose Pinazo, additional, Matilla, Gonzalo, additional, Lucena, Maria Isabel, additional, Medina-Caliz, Inmaculada, additional, and Andrade, Raul J., additional

Published
2024
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33. Novel targeted drugs for follicular and marginal zone lymphoma: a comprehensive review

Author

Andrea Rivero, Pablo Mozas, Laura Magnano, and Armando López-Guillermo

Subjects
follicular lymphoma, marginal zone lymphoma, targeted therapy, immunotherapy, CAR-T cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Although mostly incurable, indolent non-Hodgkin lymphomas (iNHL) are chronic diseases with a median overall survival approaching 20 years. In recent years, important advances in the knowledge of the biology of these lymphomas have led to the development of new drugs, mostly chemotherapy-free, with promising outcomes. With a median age of around 70 years at diagnosis, many patients with iNHL suffer from comorbid conditions that may limit treatment options. Therefore, nowadays, in the transition towards personalized medicine, several challenges lie ahead, such as identifying predictive markers for the selection of treatment, the adequate sequencing of available therapies, and the management of new and accumulated toxicities. In this review, we include a perspective on recent therapeutic advances in follicular and marginal zone lymphoma. We describe emerging data on approved and emerging novel therapies, such as targeted therapies (PI3K inhibitors, BTK inhibitors, EZH2 inhibitors), monoclonal antibodies and antibody-drug conjugates. Finally, we describe immune-directed approaches such as combinations with lenalidomide or the even more innovative bispecific T-cell engagers and chimeric antigen receptor T-cell therapy, which can achieve a high rate of durable responses with manageable toxicities, further obviating the need for chemotherapy.

Published
2023
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35. Review of the VIII institutional conference of the Bachelor of Nursing degree at the University of Buenos Aires: History and innovation

Author

Simeoni, Irene Amelia, primary, Lepez, Carlos Oscar, additional, Palacios, Noelia Noemí, additional, Gómez Turchiaro, Rubén Alberto, additional, Betancourt, María Adriana, additional, Bruno, Laura Mabel, additional, De Nazzari, Mónica Alicia, additional, Cari, Adriana Noelia, additional, Torres, Ruth Noemí, additional, Beatriz Senrra, Alejandra Beatriz, additional, Luna, José Nolberto, additional, Gromatovich, María, additional, Albarracín, María Celeste, additional, Burzoni, Stella Marís, additional, Torres, Natalia, additional, Pettenazza, Mónica, additional, Guerra Cebria, Ana Verónica, additional, Holovatuck, Mariana Florencia, additional, David López, Guillermo, additional, Armoa, Rossana Fabio, additional, and Salas, Reneé Ismael, additional

Published
2024
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37. The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Author

Campo, Elias, Jaffe, Elaine S., Cook, James R., Quintanilla-Martinez, Leticia, Swerdlow, Steven H., Anderson, Kenneth C., Brousset, Pierre, Cerroni, Lorenzo, de Leval, Laurence, Dirnhofer, Stefan, Dogan, Ahmet, Feldman, Andrew L., Fend, Falko, Friedberg, Jonathan W., Gaulard, Philippe, Ghia, Paolo, Horwitz, Steven M., King, Rebecca L., Salles, Gilles, San-Miguel, Jesus, Seymour, John F., Treon, Steven P., Vose, Julie M., Zucca, Emanuele, Advani, Ranjana, Ansell, Stephen, Au, Wing-Yan, Barrionuevo, Carlos, Bergsagel, Leif, Chan, Wing C., Cohen, Jeffrey I., d'Amore, Francesco, Davies, Andrew, Falini, Brunangelo, Ghobrial, Irene M., Goodlad, John R., Gribben, John G., Hsi, Eric D., Kahl, Brad S., Kim, Won-Seog, Kumar, Shaji, LaCasce, Ann S., Laurent, Camille, Lenz, Georg, Leonard, John P., Link, Michael P., Lopez-Guillermo, Armando, Mateos, Maria Victoria, Macintyre, Elizabeth, Melnick, Ari M., Morschhauser, Franck, Nakamura, Shigeo, Narbaitz, Marina, Pavlovsky, Astrid, Pileri, Stefano A., Piris, Miguel, Pro, Barbara, Rajkumar, Vincent, Rosen, Steven T., Sander, Birgitta, Sehn, Laurie, Shipp, Margaret A., Smith, Sonali M., Staudt, Louis M., Thieblemont, Catherine, Tousseyn, Thomas, Wilson, Wyndham H., Yoshino, Tadashi, Zinzani, Pier-Luigi, Dreyling, Martin, Scott, David W., Winter, Jane N., and Zelenetz, Andrew D.

Published
2022
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38. Genetic and phenotypic attributes of splenic marginal zone lymphoma

Author

Bonfiglio, Ferdinando, Bruscaggin, Alessio, Guidetti, Francesca, Terzi di Bergamo, Lodovico, Faderl, Martin, Spina, Valeria, Condoluci, Adalgisa, Bonomini, Luisella, Forestieri, Gabriela, Koch, Ricardo, Piffaretti, Deborah, Pini, Katia, Pirosa, Maria Cristina, Cittone, Micol Giulia, Arribas, Alberto, Lucioni, Marco, Ghilardi, Guido, Wu, Wei, Arcaini, Luca, Baptista, Maria Joao, Bastidas, Gabriela, Bea, Silvia, Boldorini, Renzo, Broccoli, Alessandro, Buehler, Marco Matteo, Canzonieri, Vincenzo, Cascione, Luciano, Ceriani, Luca, Cogliatti, Sergio, Corradini, Paolo, Derenzini, Enrico, Devizzi, Liliana, Dietrich, Sascha, Elia, Angela Rita, Facchetti, Fabio, Gaidano, Gianluca, Garcia, Juan Fernando, Gerber, Bernhard, Ghia, Paolo, Gomes da Silva, Maria, Gritti, Giuseppe, Guidetti, Anna, Hitz, Felicitas, Inghirami, Giorgio, Ladetto, Marco, Lopez-Guillermo, Armando, Lucchini, Elisa, Maiorana, Antonino, Marasca, Roberto, Matutes, Estella, Meignin, Veronique, Merli, Michele, Moccia, Alden, Mollejo, Manuela, Montalban, Carlos, Novak, Urban, Oscier, David Graham, Passamonti, Francesco, Piazza, Francesco, Pizzolitto, Stefano, Rambaldi, Alessandro, Sabattini, Elena, Salles, Gilles, Santambrogio, Elisa, Scarfò, Lydia, Stathis, Anastasios, Stüssi, Georg, Geyer, Julia T., Tapia, Gustavo, Tarella, Corrado, Thieblemont, Catherine, Tousseyn, Thomas, Tucci, Alessandra, Vanini, Giorgio, Visco, Carlo, Vitolo, Umberto, Walewska, Renata, Zaja, Francesco, Zenz, Thorsten, Zinzani, Pier Luigi, Khiabanian, Hossein, Calcinotto, Arianna, Bertoni, Francesco, Bhagat, Govind, Campo, Elias, De Leval, Laurence, Dirnhofer, Stefan, Pileri, Stefano A., Piris, Miguel A., Traverse-Glehen, Alexandra, Tzankov, Alexander, Paulli, Marco, Ponzoni, Maurilio, Mazzucchelli, Luca, Cavalli, Franco, Zucca, Emanuele, and Rossi, Davide

Published
2022
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39. Post-landing major element quantification using SuperCam laser induced breakdown spectroscopy

Author

Anderson, Ryan B., Forni, Olivier, Cousin, Agnes, Wiens, Roger C., Clegg, Samuel M., Frydenvang, Jens, Gabriel, Travis S.J., Ollila, Ann, Schröder, Susanne, Beyssac, Olivier, Gibbons, Erin, Vogt, David S., Clavé, Elise, Manrique, Jose-Antonio, Legett, Carey, IV, Pilleri, Paolo, Newell, Raymond T., Sarrao, Joseph, Maurice, Sylvestre, Arana, Gorka, Benzerara, Karim, Bernardi, Pernelle, Bernard, Sylvain, Bousquet, Bruno, Brown, Adrian J., Alvarez-Llamas, César, Chide, Baptiste, Cloutis, Edward, Comellas, Jade, Connell, Stephanie, Dehouck, Erwin, Delapp, Dorothea M., Essunfeld, Ari, Fabre, Cecile, Fouchet, Thierry, Garcia-Florentino, Cristina, García-Gómez, Laura, Gasda, Patrick, Gasnault, Olivier, Hausrath, Elisabeth M., Lanza, Nina L., Laserna, Javier, Lasue, Jeremie, Lopez, Guillermo, Madariaga, Juan Manuel, Mandon, Lucia, Mangold, Nicolas, Meslin, Pierre-Yves, Nelson, Anthony E., Newsom, Horton, Reyes-Newell, Adriana L., Robinson, Scott, Rull, Fernando, Sharma, Shiv, Simon, Justin I., Sobron, Pablo, Fernandez, Imanol Torre, Udry, Arya, Venhaus, Dawn, McLennan, Scott M., Morris, Richard V., and Ehlmann, Bethany

Published
2022
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40. Intercambio político: Un concepto a revisión

Author

Carlos Ricardo Aguilar Astorga, Saturnino Canto Chac, Angélica Cristal Fernández Andrade, Carlos Israel Ham Ramírez, Ángel Mundo López, Guillermo Santana Barrios and Carlos Ricardo Aguilar Astorga, Saturnino Canto Chac, Angélica Cristal Fernández Andrade, Carlos Israel Ham Ramírez, Ángel Mundo López, Guillermo Santana Barrios

Published
2022

41. Severe infections in patients with lymphoproliferative diseases treated with new targeted drugs: A multicentric real‐world study

Author

Maria Stefania Infante, Ana Fernández‐Cruz, Lucia Núñez, Cecilia Carpio, Ana Jiménez‐Ubieto, Javier López‐Jiménez, Lourdes Vásquez, Raquel Del Campo, Samuel Romero, Carmen Alonso, Daniel Morillo, Margarita Prat, José Luis Plana, Paola Villafuerte, Gabriela Bastidas, Ana Bocanegra, Ángel Serna, Rodrigo De Nicolás, Juan Marquet, Carmen Mas‐Ochoa, Raúl Cordoba, Julio García‐Suárez, Alessandra Comai, Xavier Martín, Mariana Bastos‐Oreiro, Cristina Seri, Belén Navarro‐Matilla, Armando López‐Guillermo, Joaquín Martínez‐López, José Ángel Hernández‐Rivas, Isabel Ruiz‐Camps, Carlos Grande, and Grupo Español de Linfomas y Trasplante Autólogo de Medula Ósea (GELTAMO)

Subjects
infectious diseases, infectious risk, lymphoproliferative disease, prophylaxis, targeted drugs, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Lymphoid neoplasms treatment has recently been renewed to increase antitumor efficacy and conventional chemotherapies toxicities. Limited data have been published about the infection risk associated with these new drugs, therefore this study analyzes the infectious complications in patients with lymphoproliferative diseases (LPD) treated with monoclonal antibodies (obinutuzumab, ofatumumab, brentuximab, nivolumab, or pembrolizumab), BTK inhibitors (ibrutinib and acalabrutinib), PI3K inhibitors (idelalisib) and BCL2 inhibitors (venetoclax). Methods Multicenter retrospective study of 458 LPD patients treated with targeted therapies in real‐life setting, in 18 Spanish institutions, from the time of their commercial availability to August 2020. Results Severe infections incidence was 23% during 17‐month median follow‐up; cumulative incidence was higher in the first 3–6 months of targeted drug treatment and then decreased. The most frequent etiology was bacterial (54%). Nine (6%) Invasive fungal infections (IFI) were observed, in its majority in chronic lymphocytic leukemia (CLL) patients treated predominantly with ibrutinib. Significant risk factors for severe infection were: severe lymphopenia (p = 0.009, OR 4.7, range 1.3–1.7), combined targeted treatment vs single agent treatment (p = 0.014 OR 2.2 range 1.1–4.2) and previous rituximab (p = 0.03 OR 1.8, range 1.05–3.3). Infection‐related mortality was 6%. In 22% of patients with severe infections, definitive discontinuation of the targeted drug was observed. Conclusion A high proportion of patients presented severe infections during follow‐up, with non‐negligible attributable mortality, but infection incidence is not superior to the one observed during the chemotherapy era. In selected cases with specific risk factors for infection, antimicrobial prophylaxis should be considered.

Published
2021
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42. Interleukin-1 receptor associated kinase 1/4 and bromodomain and extra-terminal inhibitions converge on NF-κB blockade and display synergistic antitumoral activity in activated B-cell subset of diffuse large B-cell lymphoma with MYD88 L265P mutation

Author

Ivan Dlouhy, Marc Armengol, Clara Recasens-Zorzo, Marcelo L Ribeiro, Patricia Pérez-Galán, Francesc Bosch, Armando López-Guillermo, and Gaël Roué

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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43. FAKE NEWS E INFODEMIA: UMA REFLEXÃO SOBRE OS SEUS IMPACTOS NO CENÁRIO DE FORMAÇÃO DOS TÉCNICOS E TECNÓLOGOS EM RADIOLOGIA

Author

Fontainha, Críssia Carem Paiva, primary, Nogueira, Luciana Batista, additional, Trindade, Lucas Monteiro da, additional, Moraes, Janaina Fagundes de, additional, Oliveira, Marcus Vinicius Linhares de, additional, Gontijo, Rodrigo Modesto Gadelha, additional, Batista, Adriana de Souza Medeiros, additional, Oliveira, Cássio Miri, additional, López, Guillermo Alberto, additional, and Souza Filho, Adilson Rodrigues de, additional

Published
2022
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44. Basic design considerations for a frequency step-tunable electron cyclotron wave system to suppress NTMs in DEMO

Author

Wu, Chuanren, Aiello, Gaetano, Avramidis, Konstantinos A., Bruschi, Alessandro, Fable, Emiliano, Franke, Thomas, Gantenbein, Gerd, Garavaglia, Saul, Granucci, Gustavo, Illy, Stefan, Janky, Filip, Jelonnek, John, Kudláček, Ondřej, Moro, Alessandro, Poli, Emanuele, Ruess, Tobias, Scherer, Theo, Schramm, Raphael, Siccinio, Mattia, Snicker, Antti, Strauß, Dirk, Suárez López, Guillermo, Tardini, Giovanni, Thumm, Manfred, Tran, Minh Quang, and Zohm, Hartmut

Published
2021
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45. Evaluación económica de revascularización completa y revascularización guiada por ecocardiografía de estrés en el SCACEST con enfermedad multivaso

Author

Flores-Ríos, Xacobe, Calviño-Santos, Ramón A., Estévez-Loureiro, Rodrigo, Peteiro-Vázquez, Jesús, Salgado-Fernández, Jorge, Rodríguez-Vilela, Alejandro, Franco-Gutiérrez, Raúl, Bouzas-Mosquera, Alberto, Rodríguez-Fernández, José Ángel, Marzoa-Rivas, Raquel, González-Juanatey, Carlos, Aldama-López, Guillermo, Piñón-Esteban, Pablo, Vázquez-González, Nicolás, Muñiz-García, Javier, and Vázquez-Rodríguez, José Manuel

Published
2021
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48. Pain as a disease in the new International Classification of Diseases (ICD-11): Latin American expert consensus

Author

Narvaez Tamayo, Marco A, primary, Aguayo, Carlos, additional, Atencio, Elias, additional, Garcia, Joao Batista, additional, Cabrera, Carmen, additional, Castañeda, Celina, additional, Castroman, Pablo, additional, Elizeche, Graciela, additional, Gomez, Patricia, additional, Guaycochea, Santiago, additional, Guerrero, Marixa, additional, Guillen, Rocio, additional, Pereira, Carla Leal, additional, López, Guillermo, additional, Macias, Jacqueline, additional, Martinez, Bethania, additional, Mejia, Felipe, additional, Orrillo, Enrique, additional, Oliveira, José O, additional, Piedimonte, Fabian, additional, Samayoa, Francisco, additional, and Toro, Martin, additional

Published
2024
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