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Adrián Montesano,1 María Angeles López-González,2 Luis Angel Saúl,2 Guillem Feixas1 1Department of Personality, Assessment and Psychological Treatments, University of Barcelona, Barcelona, 2Department of Personality, Assessment and Psychological Treatments, Faculty of Psychology, National Distance Education University, Madrid, Spain Abstract: Recent research has highlighted the role of implicative dilemmas in a variety of clinical conditions. These dilemmas are a type of cognitive conflict, in which different aspects of the self are countered in such a way that a desired change in a personal dimension (eg, symptom improvement) may be hindered by the need of personal coherence in another dimension. The aim of this study was to summarize, using a meta-analytical approach, the evidence relating to the presence and the level of this conflict, as well as its relationship with well-being, in various clinical samples. A systematic review using multiple electronic databases found that out of 37 articles assessed for eligibility, nine fulfilled the inclusion criteria for meta-analysis. Random effects model was applied when computing mean effect sizes and testing for heterogeneity level. Statistically significant associations were observed between the clinical status and the presence of dilemmas, as well as level of conflict across several clinical conditions. Likewise, the level of conflict was associated with symptom severity. Results highlighted the clinical relevance and the transdiagnostic nature of implicative dilemmas. Keywords: implicative dilemmas, cognitive conflicts, intrapersonal conflicts, meta-analysis

Prostate cancer is the second most common neoplasia amongst men worldwide. Hereditary susceptibility and ancestral heritage are well-established risk factors that explain the disparity trends across different ethnicities, populations, and regions even within the same country. The Y-chromosome has been considered a prototype biomarker for male health. African, European, Middle Eastern, and Hispanic ancestries exhibit the highest incidences of such neoplasia; Asians have the lowest rates. Nonetheless, the contribution of ancestry patterns has been scarcely explored among Latino males. The Mexican population has an extremely diverse genetic architecture where all the aforementioned ancestral backgrounds converge. Trans-ethnic research could illuminate the aetiology of prostate cancer, involving the migratory patterns, founder effects, and the ethnic contributions to its disparate incidence rates. The contribution of the ancestral heritage to prostate cancer risk were explored through a case-control study (152 cases and 372 controls) study in Mexican Mestizo males. Seventeen microsatellites were used to trace back the ancestral heritage using two Bayesian predictor methods. The lineage R1a seems to contribute to prostate cancer (ORadjusted:8.04, 95%CI:1.41–45.80) development, whereas E1b1a/E1b1b and GHIJ contributed to well-differentiated (Gleason ≤ 7), and late-onset prostate cancer. Meta-analyses reinforced our findings. The mentioned lineages exhibited a connection with the Middle Eastern and North African populations that enriched the patrilineal diversity to the southeast region of the Iberian Peninsula. This ancestral legacy arrived at the New World with the Spanish and Sephardim migrations. Our findings reinforced the contribution of family history and ethnic background to prostate cancer risk, although should be confirmed using a large sample size. Nonetheless, given its complex aetiology, in addition to the genetic component, the lifestyle and xenobiotic exposition could also influence the obtained results. [ABSTRACT FROM AUTHOR]

Fundamento: La evaluación del proceso es condición imprescindible para medir correctamente el impacto de intervenciones educativas sobre las conductas, sus determinantes psicosociales y el estadio de cambio, en el marco de la promoción de la salud. El objetivo de este trabajo es evaluar la calidad de implementación del Programa FAPACAN, diseñado para prevenir el riesgo conductual de cáncer en Atención Primaria y para mejorar sus determinantes psicosociales en el Modelo A.S.E. y el estadio de cambio según Prochaska y DiClemente. Métodos: Mediante visita al centro de salud y la cumplimentación de una lista de comprobación in situ y mediante una encuesta telefónica a los individuos que formaban la muestra, se midió la calidad de implementación. Se hallaron medidas de centralización y de asociación (coeficiente de Pearson y de Spearman). Se obtuvo un modelo de regresión múltiple con la puntuación obtenida por el entrevistado (rango de 0 a 8) y las covariables: género, edad, nivel de estudios, localidad e historia familiar de cáncer. Resultados: Las puntuaciones de calidad obtenidas oscilan entre el 72% y el 81% de la calidad óptima. Se encontraron diferencias significativas debidas al administrador (mejor cuanto menos años de ejercicio) y a la persona encuestada (mejor cuanto mayor nivel de estudios). Conclusiones: En conjunto, la calidad de implementación fue más que suficiente, a pesar de la escasa facilitación proporcionada por el sistema sanitario.

FUNDAMENTO: La prevalencia del tabaquismo en los adolescentes sigue indeseablemente elevada. Se precisan programas preventivos novedosos. Este estudio descriptivo transversal establece las variables conductuales asociadas al tabaquismo y las actividades más frecuentes de los adolescentes fuera de la escuela, útiles para plantear programas de prevención extraescolares. MÉTODO: Los datos se recogieron con un cuestionario validado en una muestra representativa de escolares asturianos de 10-11 y 13-14 años. Mediante regresión logística se estudiaron las variables asociadas al consumo de tabaco. RESULTADOS: El porcentaje de inicio del consumo oscila entre el 14,5% y el 42,5%, y el de fumadores regulares entre el 1,1% y el 12,4%, respectivamente. Se construyeron 2 modelos con las variables asociadas significativamente a la conducta de fumar, los cuales clasifican correctamente en fumador/no fumador al 98,85% y 91,39% de los niños, según la edad. Las variables ambientales (accesibilidad al tabaco y al alcohol y frecuentación de lugares de riesgo) son las primeras integrantes del modelo. Las actividades extraescolares más frecuentes son: ver TV, leer y escuchar música y ver o practicar deporte. CONCLUSIÓN: Los resultados proporcionan claves para el diseño de programas extraescolares "a medida" de las actividades de los adolescentes: publicidad en TV y en soportes musicales (discos, cintas, etc.), e información escrita personalizada en el hogar, con mensajes transmitidos por líderes juveniles del deporte, la canción y la televisión.

FUNDAMENTO: Los datos publicados sobre eficacia de programas escolares para la prevención del tabaquismo son inconsistentes. No está suficientemente estudiado el proveedor de tales programas como variable de confusión. El objetivo de este estudio fue evaluar el proceso de una intervención educativa intraescolar. MÉTODO: Líderes estudiantiles y profesores, entrenados y con guías, desarrollaron un programa de base social. Se encuestó aleatoriamente a 2 alumnos por cada aula, mediante cuestionario validado y pilotado: 318 niños. Se utilizó el Indice Kappa para medir la fiabilidad, y el Coeficiente de Correlación Intraclase, el de Pearson y el análisis de las diferencias individuales para comparar los datos de ajuste al programa, proporcionados por alumnos y profesores. RESULTADOS: La media de ajuste por aula fue 30,07 puntos (48 =100% de ajuste). El 26% de los niños no pudo citar una alternativa a las ventajas de fumar, 71,7% desconocía la frecuencia de consumo en adultos y 19,5% no pudo evocar ningún truco propio de la publicidad del tabaco. Menos de la mitad realizó un sociodrama sobre el tema, como era preceptivo. El CCI fue 0,21, Pearson 0,25 (p = 0,02) y el intervalo de concordancia entre las calificaciones de profesores y alumnos fue de 6,93 puntos (-1,70 a 5,23). CONCLUSIONES: El ajuste de la implementación al modelo de programa propuesto fue insuficiente. Encontramos escasa correspondencia entre la autocalificación del profesorado y la puntuación alcanzada por los alumnos en el ajuste al programa. La evaluación del proceso es esencial para interpretar correctamente la evaluación del impacto.

Francisco Rodríguez-Cifuentes,1,* M Angeles López-Gonzalez,1,* Fernando Rubio-Garay,2,* Gabriela Topa,3,* Pedro Belo,4,* Ricardo Pocinho,5,* Silvia Silva,6,* Juan José Fernández-Muñoz1,* 1Psychology Department, Faculty of Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain; 2Associated Center in Albacete, Universidad Nacional de Educación a Distancia, Albacete, Spain; 3Department of Social and Organizational Psychology, Faculty of Psychology, Universidad Nacional de Educación a Distancia, Madrid, Spain; 4Instituto Politécnico de Setúbal, Setúbal, Portugal; 5Instituto Politécnico de Leira- CICS NOVA, Leira, Portugal; 6Escola Superior de Educação e Ciências Sociais Instituto Politécnico de Leiria, Leiria, Portugal*These authors contributed equally to this workCorrespondence: M Angeles López-Gonzalez, Psychology Department, Faculty of Health Sciences, Universidad Rey Juan Carlos, Av. de Atenas, s/n, Alcorcón, Madrid, 28922, Spain, Email angeles.lopezg@urjc.esPurpose: A positive leisure attitude among older adults may have a beneficial effect on psychological well-being, both directly and indirectly by fostering a more positive perception of one’s health. This paper presents a correlational design that explores associations among leisure attitude, self-rated health, and psychological well-being, and analyzes the potential moderating role of gender in these relationships.Patients and Methods: The sample was selected using simple random probability sampling (N= 409; 61.9% female; Mean age = 72.9; SD = 8.43¸ Range of age 53 to 93 years). Diverse sociodemographic information was collected, and leisure attitudes, self-perceived health, and psychological well-being (positive affect and emotional ties) were assessed.Results: The results revealed a positive effect of leisure attitude on self-rated health and psychological well-being, with self-rated health fully mediating the association between the behavioral component of leisure attitude and psychological well-being. Furthermore, the moderating effect of gender on the relationship between self-rated health and psychological well-being was stronger among men.Conclusion: Positive cognitive and emotional perceptions of leisure among older adults seem to benefit psychological well-being and improve self-rated health, thereby contributing to healthy ageing.Keywords: ageing, older adults, gender, attitudes to leisure, psychological well-being, emotional ties

Objectives. The aim of this work is to examine the presence of musculoskeletal disorders (MSDs) and the exposure to psychosocial risk in a sample of 399 occupational health and safety technicians (OHSTs), deepening the associations between both aspects. Methods. The standardized Nordic questionnaire and the Decore questionnaire were used. Different descriptive and correlational analyses and a multivariate analysis model were carried out. Results. In total, 77.17% of the participants affirmed having suffered some muscle ailments. The most critical psychosocial risk factors are those related to the rewards that the worker obtains for their work, with 54.7% of the technicians in a situation of alert or emergency. It is highlighted that the fact of not feeling professionally valued, working outside working hours, having musculoskeletal discomfort and perceiving a state of poor or fair health increase the global risk index (GRI) score. Conclusions. The study highlights the high exposure of OHSTs to both physical and psychosocial risk factors as well as the significant relationship between these variables. Furthermore, the predictive model shows the variables that best predict the probability of MSDs: gender, training in emerging risks, perceived health and exposure to psychosocial risk. [ABSTRACT FROM AUTHOR]

Purpose. The aim of this work was to analyze the prevalence of work-related musculoskeletal symptoms in laboratory technicians and their relation to personal and organizational factors, as well as the lack of specific training on work-related risks. Methods. A standardized Nordic questionnaire made for the Spanish population and a survey of sociodemographic variables and organizational aspects were applied to a sample of 460 Spanish laboratory technicians. The statistical analysis was done through R version 3.4.3. Results. Of the sample studied, 84.5% presented some musculoskeletal discomfort, with a higher percentage in women. The probability of having discomfort was eight times higher for those older than 46 years and the most affected part of the body was the neck. The variables that were associated more significantly with the probability to suffer discomfort in the most affected parts of the body (neck, right shoulder and right wrist) were gender, education level, prevention knowledge and seniority. Conclusions. It is necessary to implement plans to train in specific risks according to the activities done by these professionals. [ABSTRACT FROM AUTHOR]

1. Vinclozolin (Vin) is a fungicide used in agricultural settings and is classified as an endocrine disruptor. Vin is non-enzymatically hydrolyzed to 2-[[(3,5-dichlorophenyl)-carbamoyl]oxy]-2-methyl-3-butenoic acid (M1) and 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide (M2) metabolites. There is no information about Vin biotransformation in humans, therefore, the aim of this study was to characterize its in vitro metabolism using human liver microsomes. 2. Vin was metabolized to the [3-(3,5-dichlorophenyl)-5-methyl-5-(1,2-dihydroxyethyl)-1,3-oxazolidine-2,4-dione] (M4) and N-(2,3,4-trihydroxy-2-methyl-1-oxo)-3,5-dichlorophenyl-1-carbamic acid (M7) metabolites, which are unstable and gradually converted to 3′,5′-dichloro-2,3,4-trihydroxy-2-methylbutyranilide (DTMBA, formerly denoted as M5). M4 and DTMBA metabolites co-eluted in the same HPLC peak; this co-elute peak exhibited a Michaelis-Menten kinetic, whereas M7 showed a substrate inhibition kinetics. The KM app for co-eluted M4/DTMBA and M7 was 24.2 ± 5.6 and 116.0 ± 52.6 μM, the VMax app was 0.280 ± 0.015 and 0.180 ± 0.060 nmoles/min/mg protein, and the CLint app was 11.5 and 1.5 mL/min/g protein, respectively. The Ki for M7 was 133.2 ± 63.9 μM. Cytochrome P450 (CYP) chemical inhibitors furafylline (CYP1A2), ketoconazole (CYP3A4), pilocarpine (CYP2A6) and sulfaphenazole (CYP2C9) inhibited M4/DTMBA and M7 formation, suggesting that Vin is metabolized in humans by CYP. 3. DTMBA is a stable metabolite and specific of Vin, therefore, it could be used as a biomarker of Vin exposure in humans to perform epidemiological studies. [ABSTRACT FROM AUTHOR]

This article discusses the Jewish neighborhood in Valencia, Spain, during the mid-13th century. The author comments on the role of King James I of Aragon in establishing the "Jewish Quarter" in the region. She also attempts to determine the exact location of the neighborhood, noting that only the Xerea Gate's location is known. She cites various historical records and documents, such as the "Llibre del Repartiment," to discover the location of the Amnalmelig baths, as well as ancient cartography and plans of the city itself.

Background: Malignant cell clones resistant to chemotherapy and radiotherapy frequently lead to treatment failure in patients with glioblastoma multiforme. Preliminary studies suggest that adding chloroquine to conventional therapy may improve treatment outcomes.Objective: To examine the effect of adding chloroquine to conventional therapy for glioblastoma multiforme.Design: Randomized, double-blind, placebo-controlled trial.Setting: National Institute of Neurology and Neurosurgery of Mexico.Patients: 30 patients with surgically confirmed glioblastoma confined to 1 cerebral hemisphere, with a Karnofsky performance score greater than 70, no comorbid disease, and age younger than 60 years.Interventions: Oral chloroquine at 150 mg/d for 12 months beginning on postoperative day 5 or placebo. All patients received conventional chemotherapy and radiotherapy.Measurements: Primary outcome was survival after surgery; surviving patients were followed up to October 2005. Periodic evaluation using the Karnofsky scale and imaging studies, as well as hematologic tests and ophthalmologic examinations, was done in all patients.Results: Median survival after surgery was 24 months for chloroquine-treated patients and 11 months for controls. At the end of the observation period, 6 patients treated with chloroquine had survived 59, 45, 30, 27, 27, and 20 months, respectively; 3 patients from the control group had survived 32, 25, and 22 months, respectively. Although not statistically significantly different, the rate of death with time was approximately half as large in patients receiving chloroquine as in patients receiving placebo (hazard ratio, 0.52 [95% CI, 0.21 to 1.26]; P = 0.139).Limitations: The observed advantage of chloroquine may be due to chance; differences in pretreatment characteristics and conventional treatment regimens could not be adjusted for because of the small sample size.Conclusions: Chloroquine may improve mid-term survival when given in addition to conventional therapy for glioblastoma multiforme. These results suggest that larger, more definitive studies of chloroquine as adjuvant therapy for glioblastoma are warranted. [ABSTRACT FROM AUTHOR]

Europe is undergoing rapid social change and is distinguished by its cultural superdiversity. Healthcare is facing an increasing need for professionals to adapt to this environment. Thus, the promotion of cultural competence in healthcare has become a priority. However, the training being developed and their suitability for the European context are not well known. The aim of this qualitative study has been to map the scientific literature in order to comprehend the current state of research on this topic. For this purpose, we conducted a systematic scoping review of the empirical publications focused on cultural competence interventions for healthcare professionals in European countries. The search was conducted in eight thematic (PsycINFO, MedLine, and PubPsych) and multidisciplinary databases (Academic Search Ultimate, E-Journals, Scopus, ProQuest, and Web of Science) to identify relevant publications up to 2023. Results were presented qualitatively. Out of the initial 6506 records screened, a total of 63 publications were included. Although the interventions were implemented in 23 different European countries, cultural competence interventions have not been widely adopted in Europe. Significant heterogeneity was observed in the conception and operacionalización of cultural competence models and in the implementation of the interventions. The interventions have mostly aimed at improving healthcare for minority population groups and have focused on the racial and ethnic dimensions of the individual. Future research is needed to contribute to the conceptual development of cultural competence to design programs tailored to European superdiversity. This scoping review has been registered in OSF and is available for consultation.

Introduction: Developing the capabilities of individuals, groups and communities to enhance their health has received a great deal of attention in the literature. One essential source of results is evidence-based intervention programmes, which often involve a number of different variables. This paper describes a methodology for carrying out a scoping review that maps available evidence on randomised controlled trials focusing on health promotion intervention programmes., Methods and Analysis: The scoping review protocol follows the general Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Joanna Briggs Institute guidelines. It also incorporates some modifications to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Review flowchart and complements its methodological framework. This new format, called documents, Concept, Studies, Participants, Interventions, Comparator, and Outcomes (d-CoSPICO), guides the review sequence, which is represented in a flowchart. The search will focus on different sources of information using formal (searches in thematic -PubPsych, ERIC, MedLine, PsychINFO- and multidisciplinary databases -Academic Search Ultimate, Core Collection Web of Science, Scopus and ProQuest-, repositories and other websites), informal (contact with researchers), and retrospective (previous reviews on this topic) strategies to identify relevant publications until 2021, including grey literature. Coding, identification, selection, and data extraction will be carried out following the generation of a database in which each retrieved record's content (abstract and/or full text) can be analysed. The review is expected to be completed in 2023., Ethics and Dissemination: Ethical approval is not required for this review. The d-CoSPICO framework and the results will be disseminated through (a) peer-reviewed publications; (b) presentations at scientific dissemination events and (c) training activities for applying this protocol., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

The aim of this study was to carry out a systematic review of controlled clinical trials in order to identify both specific populations and social issues which may benefit from the effective use of psychodrama psychotherapy. A search was conducted in the WoS, SCOPUS, PsychINFO, Medline, Academic Search Ultimate, ProQuest, and PubPsych databases, complemented by a manual search on relevant websites and in the reference lists of the selected studies. Randomized controlled trials (RCTs) and quasi-RCTs of group-based psychodrama psychotherapy were included. The Effective Public Health Practice Project (EPHPP) tool was adopted to assess the methodological quality of the included studies. The search identified 14 RCTs and one quasi-RCT evaluating the effects of group-based psychodrama psychotherapy. The total number of participants in the studies was 642 people. Seven studies were conducted in Turkey, two in the USA, two in Finland, one in Canada, one in Brazil, one in Italy, and one in Iran. The heterogeneity of the issues analyzed indicates that psychodrama improves the symptoms associated with a wide range of problems. Despite psychodrama's long history, most clinical trials in this field have been published this century, which suggests not only that this psychotherapeutic practice remains relevant today but also that it continues to attract substantial interest among the scientific community. Nevertheless, further research efforts are required to understand its potential benefits for psychosocial well-being.

Phenolic compounds largely contribute to the nutraceutical properties of virgin olive oil (VOO), the organoleptic attributes and the shelf life due to their antioxidant capabilities. Due to the relevance of malaxation in the oil extraction process, we tested the effects of malaxation time on the concentrations of relevant phenolic compounds in VOO, and we evaluated the influence of performing malaxation under vacuum. An increase in malaxation time significantly decreased the concentrations of aglycone isomers of oleuropein and ligstroside but, conversely, increased the oleocanthal and oleacein contents. Additionally, malaxation under vacuum led to an increase in phenolic contents compared to standard conditions carried out at atmospheric pressure. Finally, we explored the possibility of predicting the VOO oxidative stability on the basis of the phenolic profile, and a model (R 2  = 0.923; p < 0.0001) was obtained by combining the concentration of the VOO phenolic compounds and the main fatty acids., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

The exponential advance of information and communication technologies (ICT) in the last decade has led to the increasingly widespread use of new electronic devices (NED) in the workplace. The emergence of new concepts such as telework from home or mobile work (ework) represents a clear example of this phenomenon. However, the benefits resulting from these changes in work dynamics may mask potential occupational risks and impacts on health and safety derived from "nonresponsible" use of new technologies. The objective of this study was to analyze the impact of NED use in the work environment and to point out the resulting health consequences. It has been observed that desktop computers are still the most frequently used devices, except in mobile work environments, where laptops and smartphones are more prevalent. The emerging health problems detected are mainly associated with musculoskeletal, visual and psychosocial disorders. This work demonstrates the need to continue deepening the study of the emerging pathologies associated with new work environments and possible intervention measures.

Objective: To assess the effectiveness, on people with chronic pain, of an intervention (Time In) designed to reduce pain and to improve psychological symptoms., Design: A randomized clinical trial with a control group, taking three measurements over three months., Setting: Granada, Spain., Participants: A sample of 40 women aged 18 or older with a history (over 6 months) of chronic pain. The recruitment was in the Fibromyalgia Association of Granada, Spain (AGRAFIM)., Interventions: Time In is a sensorimotor intervention that combines biomechanical physiotherapeutic procedures and psychological strategies. A weekly session of 3h was planned and the total of the program was developed during five weeks., Main Measurements: Independent variables: sociodemographic information, clinical history and Time In intervention. Dependent variables: Brief Pain Inventory (BPI-S), Short-Form Health Survey (SF-12), Symptom Check List-90-R (SCL-90-R) and Clinical Outcome in Routine Evaluation (CORE-OM)., Results: Significant differences were observed between control group and intervention group of most of the scales used in postintervention and follow up measurements. Thus, significantly lower mean scores were obtained in intensity, interference and areas of pain, quality of life, psychological symptoms and behavioural change. Similar results were observed on d Cohen scores. They were 'very important' on intensity of pain (d=-1.01, d=-0.97) and interference of pain (d=-0.85, d=-0.74), with an improvement percentage from 21% to 30%., Conclusions: Time In intervention reduces pain and improves psychological symptoms in patients with fibromyalgia; this results in a better quality of life., (Copyright © 2018 The Authors. Publicado por Elsevier España, S.L.U. All rights reserved.)

Vinclozolin (V) is classified as a potent endocrine disruptor. The aim of the present study was to determine the effects of V on rat liver CYP regulation and on serum levels of testosterone and estradiol during pregnancy. Pregnancy decreased the liver total CYP content by 65%, enzyme activities of MROD, PROD, and PNPH, and testosterone hydroxylation activities, as well as the protein content of CYP2A and 3A. V exposure remarkably induced the protein content and enzyme activities of CYP1A, 2A, 2B and 3A subfamilies. Testosterone and estradiol were affected in an opposite manner, provoking a 3.5-fold increase in the estradiol/testosterone ratio. These results suggest that V could regulate the hepatic CYP expression through interaction with receptors and coactivators involved in its expression and may play an important role in hormonal balance during pregnancy. In addition, the results may also contribute to understanding the toxicity of V by in utero exposure., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Introduction and Goals: Idiopathic sudden sensorineural hearing loss is a hearing disorder of unknown cause. The spontaneous recovery rate ranges from 50 to 75% of the patients. Scientific experiments on animals support the present study in patients with sudden deafness treated with sounds., Patients and Methods: During the period 2003-2009, patients with idiopathic sudden sensorineural hearing loss were administered steroids, piracetam and antioxidants, together with the addition of sounds by means of music and words., Results: Comparing the results of patients treated with medication (n=65) and those treated with medication and sounds (n=67), it was observed that patients treated with medication and sounds had higher recovery. Within the group of patients treated with medication and sounds, 25 (37%) experienced complete recovery, 28 (42%) good recovery, 11 (16%) slight recovery and 3 (5%) poor or no recovery., Conclusion: The patients who recovered more than half of their audition accounted for 54% in the group treated with medication and for 79% in the group of patients receiving medication and sounds. Auditory recuperation showed no alterations, at least up to 12 months after therapy., (Copyright © 2011 Elsevier España, S.L. All rights reserved.)